No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
94 |
4. Check minimum number of eventsNone |
94 |
5. Include endpointsNone |
94 |
6. Filter based on genotype QC (FinnGen only) |
94 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Lichenoid drug reaction
based on the number of shared cases.
Similar with more cases:
- Lichen planus
- Lichen planus, including avohilmo
- Lichen ruber planus, wide definition including periferal and oral lichen planus
- Papulosquamous disorders
- Diseases of the skin and subcutaneous tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 477 | 331 | 146 |
| Only index persons | 447 | 310 | 137 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | - | 60.35 | 59.94 |
| Only index persons | 59.71 | 59.82 | 59.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 94 | 66 | 28 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 58.16 | 57.86 | 58.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 85
- Matched controls
- 847
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L43.2
ICD-10 Finland
Lichenoid drug reaction
+∞
122.3
85
*
L43.8
ICD-10 Finland
Other lichen planus
43.3
20.7
25
8
L43.9
ICD-10 Finland
Lichen planus, unspecified
26.6
14.1
19
9
EKA10
NOMESCO Finland
Biopsy of cheek
16.0
10.7
17
13
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
37.2
8.3
10
*
A07AA02
ATC
nystatin; oral
7.3
8.0
19
32
L43.0
ICD-10 Finland
Hypertrophic lichen planus
20.7
7.8
11
6
D07AD01
ATC
clobetasol; topical
4.1
7.0
30
99
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.6
6.9
20
44
XQ802
NOMESCO Finland
Epicutan test
10.5
6.5
12
13
ECA20
NOMESCO Finland
Biopsy of gingiva
19.8
6.4
9
5
Mortality – FinRegistry
↥Association
Association between endpoint LICHENOID_DRUG_REACTION and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| LICHENOID_DRUG_REACTION | 1.212 [0.91, 1.62] | 0.194 |
| Birth year | 0.994 [0.99, 1.0] | 0.168 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 311 females with LICHENOID_DRUG_REACTION died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have LICHENOID_DRUG_REACTION.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.102% | No data |
| 5 | 0.546% | No data |
| 10 | 1.518% | No data |
| 15 | 3.23% | No data |
| 20 | 5.826% | No data |
Relationships between endpoints
↥Index endpoint: LICHENOID_DRUG_REACTION – Lichenoid drug reaction
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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