Lichenoid drug reaction

LICHENOID_DRUG_REACTION

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L43.2# 1 out of 7 registries used, show all original rules.	97
4. Check minimum number of events None	97
5. Include endpoints None	97
6. Filter based on genotype QC (FinnGen only)	94

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	LICHENOID_DRUG_REACTION
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L432
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Lichenoid drug reaction based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	477	331	146
Only index persons	447	310	137
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	-	60.35	59.94
Only index persons	59.71	59.82	59.48

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	94	66	28
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	58.16	57.86	58.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
97: Matched controls
970

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L43.2

ICD-10 Finland

Lichenoid drug reaction

+∞

139.8

L43.8

ICD-10 Finland

Other lichen planus

40.6

23.5

L43.9

ICD-10 Finland

Lichen planus, unspecified

23.9

15.0

EKA10

NOMESCO Finland

iopsy of buccal mucosa

12.0

10.0

L43.0

ICD-10 Finland

Hypertrophic lichen planus

61.3

9.9

A07AA02

ATC

nystatin; oral

5.7

9.0

D07AD01

ATC

clobetasol; topical

4.0

8.8

111

EJA10

NOMESCO Finland

Biopsy of tongue or floor of mouth

19.3

8.3

ECA20

NOMESCO Finland

Biopsy of gingiva

36.7

8.2

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

4.5

7.9

D07AC01

ATC

betamethasone; topical

3.3

7.8

267

XQ802

NOMESCO Finland

Epicutan test

8.9

6.9

K13.78

ICD-10 Finland

Other change in the oral mucosa

11.1

6.2

K13.79

ICD-10 Finland

Change in the oral mucosa UNS

11.1

6.2

K13.74

ICD-10 Finland

Lichen rubs planus in the mouth

11.1

6.2

K03.66

ICD-10 Finland

Tooth plaque

5.7

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

118

3.72

8.01

5.7

5.1

28.60

33.54

1.28

(3019225) pH of Specimen

3.76

6.99

8.0

3.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

111

3.47

6.81

7.5

8.3

—

(3026389) Candida sp identified in Specimen by Organism specific culture

13.74

6.23

2.1

1.3

—

(1761868) Lipid panel - Serum or Plasma

282

0.28

3.90

2.8

3.3

—

(4146454) Self-monitoring of blood glucose

8.27

3.62

3.6

3.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

206

2.29

3.60

1.8

2.2

—

(3037522) Nuclear Ab [Titer] in Serum

112

2.52

3.42

1.4

1073.33

638.71

titre

—

(3013512) EKG study

278

2.15

3.35

4.6

4.2

—

(3044640) Blood type and Crossmatch panel - Blood

275

2.10

3.13

1.9

2.2

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

303

2.07

3.06

3.8

3.5

1806.53

1313.83

ng/l

0.33

259

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

10.44

3.01

1.0

1.2

—

(3012516) Albumin [Mass/volume] in Urine

280

2.05

2.94

3.0

111.20

58.81

mg/l

0.24

173

(4200892) Spirometry reversibility

2.77

2.86

1.4

1.5

—

(3009508) Creatinine [Moles/volume] in Urine

280

1.96

2.63

3.0

2.9

6.83

7.09

mmol/l

0.14

222

(3020682) Albumin/Creatinine [Ratio] in Urine

300

1.93

2.56

3.6

3.5

19.24

9.46

mg/mmol

0.24

179

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

395

1.91

2.47

2.1

2.5

—

(3044927) Protein electrophoresis panel - Urine

5.78

2.24

1.4

1.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

376

1.83

2.21

3.0

2.3

80.15

78.09

nmol/l

0.21

321

(3044889) 12 lead EKG panel

619

0.56

2.12

4.1

4.2

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

686

2.10

1.97

9.1

7.7

77.34

79.15

u/l

0.17

633

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

4.73

1.96

1.2

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

198

1.83

1.92

6.6

3.8

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

416

1.74

1.91

9.2

5.4

1.20

1.22

mmol/l

0.92

379

(3026493) Urate [Moles/volume] in Serum or Plasma

208

1.80

1.87

2.3

3.3

356.19

12159.42

umol/l

1.82

166

(40760892) CBC W Ordered Manual Differential panel - Blood

389

1.73

1.87

7.9

6.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

646

1.93

1.85

6.5

4.5

15.26

13.48

mm/h

0.46

577

(3037467) Urinalysis macro (dipstick) panel - Urine

592

1.84

6.7

4.4

—

(3002385) Erythrocyte distribution width [Ratio]

716

0.58

1.79

17.4

18.5

18.21

15.52

1.29

704

(3000330) Specific gravity of Urine by Test strip

0.00

1.76

0.0

4.4

—

(40761535) Cells panel - Urine sediment

2.15

1.75

3.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

794

2.17

1.61

15.0

15.2

71.10

75.33

ml/min/173m2

1.10

657

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.71

1.54

1.1

—

(3023419) Bacteria identified in Sputum by Culture

3.45

1.54

1.6

2.5

—

(3000494) Fungus identified in Specimen by Culture

111

1.89

1.53

1.3

1.5

—

(3017732) Neutrophils [#/volume] in Blood

2.26

1.51

1.9

2.9

2.95

10.42

e9/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

169

1.74

1.49

1.3

1.2

1.20

1.99

u/ml

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.84

1.46

1.7

1.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

466

1.61

1.45

10.4

5.9

1.20

1.22

mmol/l

0.75

390

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

3.04

1.37

1.0

1.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.47

1.33

1.5

1.9

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.87

1.30

1.0

1.1

—

(3009261) Glucose [Presence] in Urine by Test strip

436

1.54

1.25

5.6

4.2

0.00

estimate

—

(3022313) Gas panel - Capillary blood

2.26

1.25

5.4

2.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.72

1.23

1.2

1.3

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

399

1.52

1.21

5.0

3.8

35.42

35.29

g/l

0.05

370

(3029937) Albumin [Presence] in Urine by Test strip

242

1.55

1.17

7.0

4.3

0.00

estimate

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.43

1.15

1.6

1.8

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

814

1.87

1.10

5.9

5.0

1.54

1.53

mmol/l

0.03

733

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

485

1.49

1.08

5.6

6.3

11.35

10.57

umol/l

0.31

457

(3004588) Protein electrophoresis panel - Serum or Plasma

1.87

1.06

1.3

2.7

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.91

1.03

3.6

3.0

11.32

9.58

g/l

0.70

(40768797) Stomach Pathology biopsy report

126

1.63

1.01

1.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

819

1.80

0.99

5.6

5.0

4.55

4.64

mmol/l

0.31

747

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

791

1.77

0.97

5.0

4.4

1.34

1.28

mmol/l

0.16

710

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

364

1.44

0.96

3.6

4.3

17.98

36.18

ng/l

1.26

280

(36660697) Celiac disease serology panel - Serum

1.80

0.95

1.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

318

1.44

0.93

3.8

3.1

2.42

2.36

mmol/l

1.63

272

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

290

1.45

0.93

2.6

2.4

56.31

55.80

u/l

0.04

265

(40768443) Skin Pathology biopsy report

1.98

0.91

1.5

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.06

0.88

3.8

1.7

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.89

0.88

11.8

6.5

22.95

24.99

mmol/l

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

653

1.48

0.86

5.4

4.1

15.03

14.98

pmol/l

0.05

590

(3001019) Free T4 and TSH panel - Serum or Plasma

2.00

0.86

1.5

1.9

—

(3035350) Ketones [Presence] in Urine by Test strip

430

1.39

0.83

5.7

4.1

0.00

estimate

—

(3019060) Gas panel - Arterial blood

1.81

0.83

5.2

3.8

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

839

1.74

0.80

6.0

5.7

2.61

2.68

mmol/l

0.27

756

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.87

0.80

3.8

2.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

432

1.38

0.80

7.0

5.5

0.00

estimate

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.78

0.0

5.7

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

523

1.39

0.78

3.7

3.1

54.74

51.48

u/l

0.09

484

(3009343) pH of Capillary blood

1.77

0.78

5.2

2.7

—

7.44

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

2.05

0.74

1.4

1.3

—

0.01

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.76

0.71

1.3

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.61

0.69

3.0

2.2

0.20

0.21

g/l

0.24

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.68

0.68

1.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

834

1.59

0.66

18.0

15.2

19.39

23.77

mg/l

0.59

659

(40768804) Tissue Pathology biopsy report

363

1.33

0.66

2.3

2.2

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

114

1.48

0.64

3.3

4.4

6.86

12.81

ug/l

0.44

(40761511) CBC panel - Blood by Automated count

857

1.69

0.62

17.4

14.2

—

(3000991) Gas panel - Venous blood

1.60

0.62

9.8

6.1

—

(3002032) Base excess in Venous blood by calculation

1.55

0.60

3.1

3.5

1.90

2.85

mmol/l

0.63

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

215

1.35

0.60

2.4

2.1

2.59

3.48

mg/l

1.99

186

(1002224) Polysomnography panel

0.00

0.59

0.0

1.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

152

1.40

0.58

1.7

1.5

2.28

2.43

g/l

0.17

(3014576) Chloride [Moles/volume] in Serum or Plasma

118

1.43

0.54

7.3

5.3

100.69

103.62

mmol/l

0.73

118

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

200

1.34

0.54

1.4

1.8

830000315.20

467.54

pmol/l

0.78

162

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

817

1.46

0.50

6.2

5.2

6.12

6.04

mmol/l

0.17

741

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

147

1.36

0.50

1.9

1.8

—

(3019309) Folate [Moles/volume] in Red Blood Cells

184

1.33

0.49

2.0

1.7

1166.88

1241.11

nmol/l

0.12

135

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

366

1.26

0.48

1.8

2.0

98.52

99.22

pmol/l

0.03

170

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

338

1.26

0.46

6.4

4.3

—

(3000492) Spirometry study

1.48

0.43

1.9

1.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.44

0.43

1.8

1.5

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

151

1.32

0.43

1.3

68.70

40.21

iu/ml

—

(3021960) Folate [Moles/volume] in Serum or Plasma

223

0.76

0.41

1.4

1.5

23.30

23.17

nmol/l

0.01

178

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

2.0

—

39.75

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.41

0.0

1.1

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.41

0.0

2.0

—

(3020891) Body temperature

1.50

0.41

4.2

4.6

—

(3049717) Cytology report of Urine Cyto stain

1.45

0.40

2.8

3.3

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.39

0.0

3.1

—

53.11

—

(3042936) Bacteria identified in Isolate by Culture

126

1.32

0.38

1.4

1.8

—

(3002256) Pathology report gross observation

1.36

0.38

1.2

1.3

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.49

0.37

3.2

2.8

0.53

0.71

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.42

0.36

3.2

2.8

0.90

0.95

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.68

0.35

3.0

2.8

28.50

28.54

u/l

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

291

0.81

0.35

3.6

3.0

42.64

31.38

u/l

0.42

275

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.39

0.34

1.8

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.39

0.34

1.9

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

129

1.29

0.33

2.1

1.3

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

809

1.29

0.30

7.5

6.4

40.80

40.72

mmol/mol

0.03

748

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

315

1.17

0.27

4.1

3.3

—

(40758558) Short blood count panel - Blood

209

1.20

0.26

7.8

8.1

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

145

1.21

0.22

1.3

1.4

1.32

16.58

u/ml

—

(3000012) Reticulocyte production index

0.00

0.21

0.0

1.5

—

(3004775) Volume in Urine collected for unspecified duration

0.00

0.21

0.0

2.6

—

733.40

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.3

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

2.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.29

0.21

1.7

1.1

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3014037) CD3+CD4+ (T4 helper) cells/100 cells in Blood

0.00

0.21

0.0

2.5

—

49.13

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.4

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.20

0.0

2.4

—

107.50

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.20

0.0

2.4

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.20

0.0

2.4

—

4.02

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.19

0.20

2.0

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

787

1.18

0.18

6.6

5.0

2.06

2.00

mu/l

0.17

703

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.16

0.18

12.0

5.9

1.31

1.46

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.21

0.17

1.3

1.4

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

346

0.89

0.17

3.8

2.6

101.34

103.40

ug/l

0.04

314

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

415

1.11

0.15

3.4

2.6

—

(36304419) Bacteria [Presence] in Urine

248

1.12

0.15

4.0

3.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.80

0.14

5.0

3.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

115

0.85

0.11

1.5

1.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

154

1.13

0.11

3.5

2.9

0.84

1.00

e6/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.14

0.10

1.4

1.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.14

0.10

20.8

6.1

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.04

0.09

2.6

3.4

0.84

0.13

e6/l

—

(3026782) Osmolality of Urine

175

1.11

0.09

2.9

3.3

521.74

514.07

mosm/kgh2o

0.06

150

(3023368) Bacteria identified in Blood by Culture

234

1.09

0.09

2.6

4.0

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.81

0.08

15.0

5.9

0.48

0.73

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.03

0.08

2.0

1.5

—

(40761536) Microorganisms panel - Urine sediment

0.80

0.08

4.2

4.1

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

888

1.19

0.07

14.8

11.5

24.54

23.78

u/l

0.22

850

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.14

0.07

11.6

5.7

122.80

116.43

g/l

—

(3022217) INR in Platelet poor plasma by Coagulation assay

458

1.05

0.05

15.4

13.1

1.06

1.31

inr

—

135

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

160

0.93

0.04

3.8

5.2

26.96

21.62

—

(4035726) Immunohistochemistry procedure

1.11

0.04

1.3

1.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

239

0.95

0.03

3.7

4.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

137

0.94

0.01

3.0

3.2

1.67

3.69

e6/l

—

(3026008) Bacteria identified in Urine by Culture

307

0.97

0.01

3.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.07

0.01

1.8

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

104

1.07

0.01

1.9

1.6

—

(3018095) Leukocytes [#/volume] in Urine

326

1.02

0.00

4.5

3.9

60.67

57.20

e6/l

0.03

227

(3003694) ABO and Rh group [Type] in Blood

201

0.99

0.00

1.3

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

106

1.04

0.00

2.0

1.7

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.2

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

-0.00

0.0

1.4

—

(3035880) pH of Pleural fluid

0.00

-0.00

0.0

1.4

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(37021550) Renin [Units/volume] in Plasma --upright

0.00

-0.00

0.0

2.0

—

202.94

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3027008) Opiates [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

9.03

—

(3028300) Cannabinoids [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.5

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.3

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.4

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.4

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.6

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.1

—

(3000919) Neutrophils/100 leukocytes in Pleural fluid

0.00

-0.00

0.0

1.2

—

18.33

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3016879) Cocaine [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

-0.00

0.0

2.2

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

328.11

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.0

—

(3020491) Glucose [Moles/volume] in Blood

0.00

-0.00

0.0

1.7

—

7.37

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

2.2

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.00

-0.00

3.4

3.5

7.00

3668.51

u/ml

—

(3024263) Appearance of Synovial fluid

0.00

-0.00

0.0

1.1

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.0

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

-0.00

0.0

6.0

—

53.17

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

3.2

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

99.80

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3027944) Amphetamines [Presence] in Urine

0.00

-0.00

0.0

1.1

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

13.00

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.3

—

37.77

—

(3047189) Immunofixation for 24 hour Urine

0.00

-0.00

0.0

2.6

—

(3001893) Eosinophils/100 leukocytes in Pleural fluid

0.00

-0.00

0.0

1.2

—

1.14

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.4

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.3

—

55.50

—

(3022145) Colonoscopy Study observation

110

1.00

-0.00

1.3

1.2

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3005532) Lymphocytes/100 leukocytes in Pleural fluid

0.00

-0.00

0.0

1.2

—

68.00

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint LICHENOID_DRUG_REACTION and mortality.

Females

Parameter	HR [95% CI]	p-value
LICHENOID_DRUG_REACTION	1.212 [0.91, 1.62]	0.194
Birth year	0.994 [0.99, 1.0]	0.168

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 311 females with LICHENOID_DRUG_REACTION died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have LICHENOID_DRUG_REACTION.

N-year risk	Females	Males
1	0.102%	No data
5	0.546%	No data
10	1.518%	No data
15	3.23%	No data
20	5.826%	No data

Relationships between endpoints

↥

Index endpoint: LICHENOID_DRUG_REACTION – Lichenoid drug reaction

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Lichenoid drug reaction

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints