Lordosis

M13_LORDOSIS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M40.4, M40.5 Hospital discharge: ICD-9 — 7372 Cause of death: ICD-10 — M40.4, M40.5 Cause of death: ICD-9 — 7372 2 out of 7 registries used, show all original rules.	99
4. Check minimum number of events None	99
5. Include endpoints None	99
6. Filter based on genotype QC (FinnGen only)	99

Control definitions (FinnGen only)

Control exclude: M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	M13_LORDOSIS
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M40[4-5]
HD_ICD_9	7372
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M40[4-5]
COD_ICD_9	7372
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Lordosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	734	405	324
Only index persons	657	367	290
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	49.32	51.11	46.88
Only index persons	48.27	50.05	46.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	99	53	46
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	47.78	47.41	48.21

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
90: Matched controls
900

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M40.5

ICD-10 Finland

Lordosis, unspecified

+∞

64.5

M07.3*L40.5

ICD-10 Finland

Other psoriatic arthropathies

321.9

40.4

L40.5

ICD-10 Finland

Arthropathic psoriasis

+∞

38.3

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

20.8

28.3

M07.3

ICD-10 Finland

Other psoriatic arthropathies

+∞

20.6

D05AX02

ATC

calcipotriol; topical

27.4

19.1

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

28.1

18.6

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

13.9

17.9

A07EC01

ATC

sulfasalazine; oral, rectal

13.7

17.2

D05AX52

ATC

calcipotriol, combinations; topical

18.7

16.8

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

39.4

15.5

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

177.3

14.9

D07XC01

ATC

betamethasone, combinations; topical

9.9

14.5

L40.0

ICD-10 Finland

Psoriasis vulgaris

20.6

14.3

M40.4

ICD-10 Finland

Other lordosis

+∞

13.9

7372A

ICD-9 Finland

Curvature of spine, Lordosis (acquired)

+∞

13.9

M48.0

ICD-10 Finland

Spinal stenosis

163.3

13.8

L04AA13

ATC

leflunomide; oral

47.8

13.7

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

34.3

13.5

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

14.8

12.6

H02AB06

ATC

prednisolone; systemic

5.1

12.1

262

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

13.1

11.5

D07AC01

ATC

betamethasone; topical

4.8

10.9

180

L04AA01

ATC

[U] ciclosporin; systemic

+∞

10.6

M07.0*L40.5

ICD-10 Finland

Distal interphalangeal psoriatic arthropathy

+∞

10.6

D05AX03

ATC

calcitriol; topical

45.4

10.2

D07AD01

ATC

clobetasol; topical

5.9

9.9

E0000UV

ATC

4.2

9.7

227

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

21.3

9.2

E000001

ATC

4.7

9.0

107

N03AX16

ATC

pregabalin; oral

5.5

8.9

N02AX02

ATC

tramadol; systemic, rectal

4.0

8.6

187

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

98.7

8.6

M073, M405

ICD-10 Finland

+∞

8.5

M43.1

ICD-10 Finland

Spondylolisthesis

+∞

8.5

L88

ICPC

Rheumatoid/seropositive arthritis

14.9

8.2

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

10.3

7.9

L04AB01

ATC

etanercept; parenteral

49.3

7.9

N02AA05

ATC

oxycodone; systemic

6.6

7.8

D05AA

ATC

Tars

86.8

7.5

S91

ICPC

Psoriasis

+∞

7.4

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

5.5

7.3

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

8.1

6.5

M54.5

ICD-10 Finland

Low back pain

3.9

6.5

E000002

ATC

4.9

6.5

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

19.7

6.4

M07.0

ICD-10 Finland

Distal interphalangeal psoriatic arthropathy

+∞

6.3

M43.0

ICD-10 Finland

Spondylolysis

+∞

6.3

NA3EA

NOMESCO Finland

Lumbar spine X-ray examination with flexion

+∞

6.3

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

3.6

6.2

119

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

4.64

9.51

2.8

1.5

—

(3042936) Bacteria identified in Isolate by Culture

4.30

9.26

3.0

1.8

—

(42870588) Differential panel, method unspecified - Blood

251

3.53

8.84

12.6

4.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

486

4.10

7.99

6.5

3.7

—

(3001604) Monocytes [#/volume] in Blood

387

3.26

7.16

13.9

5.0

e9/l

0.6

1.57

339

(3006315) Basophils [#/volume] in Blood

387

3.26

7.16

13.9

5.0

e9/l

0.0

0.28

339

(3021601) Nitrite [Presence] in Urine by Test strip

327

3.12

7.07

6.9

4.4

estimate

0.0

—

(3013115) Eosinophils [#/volume] in Blood

404

3.18

6.77

14.4

5.3

e9/l

0.2

0.17

359

(3009261) Glucose [Presence] in Urine by Test strip

332

2.92

6.34

5.4

3.1

estimate

0.0

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

456

3.12

6.14

16.2

9.8

e9/l

3.8

4.0

0.73

394

(3035350) Ketones [Presence] in Urine by Test strip

322

2.82

5.97

5.5

3.2

estimate

0.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

567

3.60

5.87

9.3

3.3

mm/h

14.1

10.3

1.65

516

(3005719) IgG [Mass/volume] in Serum or Plasma

3.82

5.16

5.9

2.2

g/l

9.9

9.8

0.05

(3045414) Leukocytes [Presence] in Urine

5.74

5.16

1.4

1.6

—

(3023368) Bacteria identified in Blood by Culture

168

2.68

4.85

7.7

3.7

—

(3000330) Specific gravity of Urine by Test strip

4.25

4.70

3.8

4.2

—

(3014051) Protein [Presence] in Urine by Test strip

12.41

4.34

1.4

2.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

233

2.39

4.20

5.7

2.6

—

(3018095) Leukocytes [#/volume] in Urine

234

2.38

4.16

5.9

3.1

e6/l

205.6

67.3

0.55

164

(3011397) Hemoglobin [Presence] in Urine by Test strip

138

2.56

4.01

5.0

2.9

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

301

2.24

3.78

7.8

4.5

mmol/l

1.2

0.43

277

(3024561) Albumin [Mass/volume] in Serum or Plasma

302

2.23

3.74

6.4

4.0

g/l

34.5

35.6

0.85

284

(3021788) Differential panel - Synovial fluid

10.53

3.54

1.2

—

(3032080) INR in Blood by Coagulation assay

285

2.15

3.38

10.1

6.3

inr

1.3

1.2

—

100

(3022621) pH of Urine by Test strip

3.46

3.34

2.3

2.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

331

2.12

3.31

10.3

5.6

mmol/l

1.2

0.59

286

(3029937) Albumin [Presence] in Urine by Test strip

165

2.28

3.30

6.6

3.4

estimate

0.0

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

3.36

3.21

6.3

2.2

mmol/l

1.8

2.7

—

(3022313) Gas panel - Capillary blood

3.72

3.14

6.9

2.0

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.92

3.13

6.7

3.6

0.0

0.3

—

(3019150) Specific gravity of Urine by Refractometry

139

2.30

3.09

6.9

3.1

kg/l

1.0

—

(36304419) Bacteria [Presence] in Urine

171

2.18

3.00

4.3

2.5

—

(3002179) Metamyelocytes/100 leukocytes in Blood

2.91

2.94

5.8

3.7

0.4

0.3

—

(40761535) Cells panel - Urine sediment

2.97

2.84

4.8

2.7

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

5.29

2.78

1.4

1.1

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

5.29

2.78

1.1

1.5

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

5.29

2.78

1.1

1.5

—

(3026008) Bacteria identified in Urine by Culture

192

2.08

2.77

3.6

2.6

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

6.30

2.74

1.5

1.1

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

2.97

2.65

6.3

2.1

kpa

5.6

5.4

0.09

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

263

1.95

2.60

6.5

3.2

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

5.72

2.58

1.2

1.0

—

(3012544) pH of Venous blood

2.53

2.57

3.4

3.0

—

(3017181) Myelocytes/100 leukocytes in Blood

2.58

2.53

6.7

3.5

0.6

1.4

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

2.58

2.53

2.7

2.1

g/l

0.2

0.32

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.42

2.48

4.3

4.7

u/l

213.2

219.4

0.19

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

339

1.88

2.44

5.7

3.5

—

(3042631) Mycobacterium sp identified in Specimen

6.51

2.40

3.2

1.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

194

1.96

2.36

5.1

3.0

—

(3025159) Blasts/100 leukocytes in Blood

2.62

2.31

6.6

3.8

0.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

5.78

2.24

1.4

1.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.25

2.23

1.7

1.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.75

2.18

1.9

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

805

2.61

2.09

27.1

11.0

mg/l

17.6

23.5

1.58

603

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.99

2.06

10.2

3.3

mmol/l

25.2

25.5

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

239

1.80

1.96

4.1

3.2

mmol/l

2.3

0.00

212

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

4.72

1.96

1.4

1.8

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

4.72

1.96

3.2

1.7

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

3.34

1.92

2.1

1.4

g/l

1.1

1.2

—

(3044640) Blood type and Crossmatch panel - Blood

232

1.79

1.91

4.4

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.23

1.80

2.6

1.6

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.65

1.79

5.1

2.9

—

(3026493) Urate [Moles/volume] in Serum or Plasma

185

1.80

1.78

4.9

2.4

umol/l

361.6

3658.6

0.77

164

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.34

1.75

1.2

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

178

1.80

1.74

4.5

1.7

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.99

1.73

1.0

1.2

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.99

1.73

3.6

1.7

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.08

1.71

11.6

3.7

mmol/l

1.1

1.0

0.35

(46235355) HIV 1 and 2 tests - Meaningful Use set

138

1.87

1.71

1.7

—

(3018418) pH of Serum or Plasma

213

1.74

1.70

5.2

3.8

7.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.70

1.63

7.0

1.7

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

3.70

1.63

4.0

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.13

1.63

2.6

1.6

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.82

1.61

1.1

1.6

—

(3019309) Folate [Moles/volume] in Red Blood Cells

109

1.92

1.61

1.6

nmol/l

763.0

1176.7

1.39

(3021589) Normoblasts [#/volume] in Blood

372

1.63

1.57

13.9

8.6

e9/l

0.0

0.56

309

(3034770) Mitochondria Ab [Titer] in Serum

2.97

1.53

1.2

1.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.50

1.50

2.1

2.5

1.3

1.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

187

1.69

1.45

11.2

4.7

—

(3027315) Oxygen [Partial pressure] in Blood

3.23

1.45

8.0

1.8

kpa

7.9

8.6

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.23

1.45

8.0

1.8

kpa

5.2

4.9

—

(3010421) pH of Blood

3.23

1.45

8.0

1.8

7.4

—

(3019225) pH of Specimen

2.21

1.45

10.4

3.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

278

1.60

1.38

1.9

1.6

pmol/l

98.3

95.8

0.11

141

(3012516) Albumin [Mass/volume] in Urine

208

1.63

1.35

2.6

3.1

mg/l

124.0

42.4

0.36

134

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

272

1.58

1.31

5.9

3.2

ng/l

27.7

77.1

1.43

180

(3037522) Nuclear Ab [Titer] in Serum

1.86

1.30

1.3

titre

240.0

458.8

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.40

1.30

2.1

2.5

0.6

0.7

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.87

1.30

1.0

1.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

117

1.77

1.30

1.9

1.5

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

126

1.74

1.27

1.1

1.2

iu/ml

19.7

27.6

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.49

1.26

1.0

1.2

—

(3013512) EKG study

222

1.58

1.21

5.1

3.3

—

(3008898) HLA-B27 [Presence]

2.39

1.20

1.2

1.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

104

1.77

1.19

3.4

1.8

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.58

1.16

1.2

1.3

—

(3049717) Cytology report of Urine Cyto stain

2.45

1.10

1.2

3.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

115

1.69

1.09

1.1

1.2

u/ml

60.4

3.0

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.34

1.04

1.4

1.6

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.34

1.04

1.0

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.34

1.04

1.0

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.34

1.04

1.0

1.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

224

1.49

0.96

3.7

3.9

mg/mmol

15.2

7.1

0.27

146

(40758558) Short blood count panel - Blood

207

1.49

0.94

11.3

6.9

—

(4035726)

1.79

0.93

1.6

1.3

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.21

0.93

4.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

147

1.54

0.90

2.9

1.4

g/l

1.7

2.2

1.44

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.06

0.88

3.7

1.6

—

(40768443) Skin Pathology biopsy report

1.81

0.77

1.2

1.1

—

(40761536) Microorganisms panel - Urine sediment

1.70

0.76

2.3

3.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.97

0.71

3.6

2.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.90

0.69

3.2

2.2

—

(3025941) Bacteria identified in Stool by Culture

1.63

0.66

1.1

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.76

0.64

2.0

2.3

—

(3000991) Gas panel - Venous blood

1.65

0.63

5.8

3.5

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

584

1.33

0.62

3.1

3.6

pmol/l

14.6

14.7

0.14

532

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.70

0.62

1.2

1.1

nmol/l

26.0

39.1

—

(3000494) Fungus identified in Specimen by Culture

1.53

0.61

3.5

1.2

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.61

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.61

0.0

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.61

0.0

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.61

0.0

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.61

0.0

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.61

0.0

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.61

0.0

1.4

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.59

0.0

1.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.71

0.58

1.5

1.6

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

833

1.51

0.57

26.3

12.0

mmol/l

139.3

139.8

1.05

804

(3019060) Gas panel - Arterial blood

1.62

0.55

3.3

4.2

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

119

1.41

0.52

7.9

2.9

mmol/l

0.9

0.8

0.37

114

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.50

0.50

3.5

2.7

—

(40768804) Tissue Pathology biopsy report

335

1.27

0.50

2.4

2.0

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

838

1.45

0.49

26.5

12.0

mmol/l

4.0

0.16

809

(3044889) 12 lead EKG panel

557

1.25

0.45

3.7

3.4

—

(3003694) ABO and Rh group [Type] in Blood

212

0.76

0.41

1.4

—

(40768793) Breast Pathology biopsy report

0.00

0.40

0.0

1.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.46

0.36

1.0

1.4

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.46

0.36

1.3

1.4

iu/ml

—

167.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.68

0.35

22.7

6.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

536

1.20

0.34

3.9

3.1

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.35

0.31

6.6

2.3

umol/l

16.5

7.4

0.33

(3022145) Colonoscopy Study observation

1.35

0.31

1.2

1.3

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.32

0.31

3.7

3.8

mmol/l

1.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

882

1.39

0.31

28.8

12.8

umol/l

86.0

76.1

0.56

882

(4010399)

1.29

0.30

2.1

1.4

—

(3000492) Spirometry study

1.35

0.29

2.1

1.3

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

342

1.18

0.29

3.6

2.1

ug/l

91.4

140.3

1.03

307

(36660697) Celiac disease serology panel - Serum

1.32

0.29

1.0

1.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

798

1.25

0.29

4.3

3.6

mmol/l

1.5

1.3

2.00

725

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

132

1.25

0.28

2.0

3.3

mmol/l

2.5

0.21

116

(40761511) CBC panel - Blood by Automated count

864

1.30

0.26

25.8

10.7

—

(3009542) Hematocrit [Volume Fraction] of Blood

780

1.21

0.25

24.9

11.4

40.4

40.7

0.13

607

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

219

0.84

0.23

2.6

3.4

22.9

22.3

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.2

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.8

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

8.4

—

1063.6

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

13.3

—

2058.9

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.21

0.0

2.7

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.21

0.0

2.0

—

13.2

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.3

—

17.4

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.29

0.21

1.5

1.2

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.2

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.20

0.0

1.1

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

195

1.16

0.19

2.1

1.6

mmol/l

1.8

1.4

0.64

161

(1761868) Lipid panel - Serum or Plasma

356

0.89

0.17

4.1

2.6

—

(3003396) Base excess in Arterial blood by calculation

1.12

0.16

7.5

4.9

mmol/l

1.6

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

848

0.87

0.13

4.9

4.5

mmol/l

2.8

0.15

770

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

792

1.13

0.12

20.7

10.6

ml/min/173m2

83.5

84.2

0.09

640

(1002224) Polysomnography panel

1.14

0.10

1.0

1.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

114

0.86

0.10

1.6

1.4

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

265

0.92

0.08

3.9

4.1

ug/l

1.3

3.1

0.91

236

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.03

0.08

1.3

1.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.04

0.07

1.5

1.8

—

(40768797) Stomach Pathology biopsy report

1.13

0.06

1.4

1.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

100

0.89

0.06

1.4

1.8

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

743

0.93

0.06

4.2

4.1

mu/l

1.8

1.9

0.12

671

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

830

1.08

0.04

4.7

4.1

mmol/l

4.7

0.02

758

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

152

0.98

0.00

1.3

1.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

826

1.03

0.00

4.7

4.0

mmol/l

1.4

1.5

1.13

749

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

759

1.01

0.00

6.0

5.3

mmol/mol

39.3

39.6

0.10

704

(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma

0.00

0.0

2.7

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.3

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.3

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3010813) Leukocytes [#/volume] in Blood

930

1.00

0.00

38.3

16.6

e9/l

6.9

6.5

1.56

896

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

1.0

—

(4024509)

0.00

0.0

1.3

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.02

0.00

2.2

—

20.6

—

(3004451) EKG impression Narrative

0.00

0.0

1.5

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.5

—

1.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.99

0.00

2.4

1.6

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3002256) Pathology report gross observation

0.92

0.00

1.3

—

(3007461) Platelets [#/volume] in Blood

927

1.05

0.00

38.2

16.5

e9/l

258.3

249.7

0.55

898

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.92

0.00

1.3

1.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.89

0.00

1.1

1.4

—

(3026361) Erythrocytes [#/volume] in Blood

930

1.00

0.00

38.2

16.5

e12/l

4.5

0.53

895

(3000963) Hemoglobin [Mass/volume] in Blood

930

1.00

0.00

38.6

16.5

g/l

135.1

137.5

0.72

912

(3017446) Testosterone [Moles/volume] in Serum or Plasma

0.97

0.00

3.3

1.8

nmol/l

8.9

15.0

—

(3016038) Potassium [Moles/volume] in Urine

0.00

-0.00

0.0

1.0

—

34.4

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(4027681)

0.00

-0.00

0.0

1.0

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.6

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.4

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.4

—

(3020491) Glucose [Moles/volume] in Blood

0.00

-0.00

0.0

1.4

—

6.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

3.2

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.0

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

1612.4

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_LORDOSIS and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
M13_LORDOSIS	1.788 [1.23, 2.6]	0.002
Birth year	0.984 [0.97, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 251 males with M13_LORDOSIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_LORDOSIS.

N-year risk	Females	Males
1	No data	0.306%
5	No data	1.995%
10	No data	5.138%
15	No data	9.005%
20	No data	15.167%

Relationships between endpoints

↥

Index endpoint: M13_LORDOSIS – Lordosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Lordosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints