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This is a non-core endpoint: only basic statistics are computed.

Benign neoplasm: Retina

CD2_BENIGN_RETINA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D31.2&
  • Hospital discharge: ICD-9 2245
  • Hospital discharge: ICD-8 22404
  • Cause of death: ICD-10 D31.2&
  • Cause of death: ICD-9 2245
  • Cause of death: ICD-8 22404

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D31
Name in latin
Neoplasma benignum retinae

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 191 111 80
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 57.72 52.66 64.74

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
165
Matched controls
1649
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D31.2
ICD-10 Finland
Benign neoplasm: Retina
+∞
232.4
163
*
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
95.8
40.2
43
6
XCK10
NOMESCO Finland
Photography of fundus of eye
11.0
29.0
60
81
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
238.6
21.1
21
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
14.0
20.7
36
32
XCD10
NOMESCO Finland
Electrophysiological examination of eye
22.7
18.9
27
14
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.5
13.8
55
163
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.9
11.5
33
67
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.9
11.4
39
97
CKC20
NOMESCO Finland
Cryopexy of undetached retina
105.7
9.5
10
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
105.7
9.5
10
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
9.5
9
*
115
Kela drug reimbursment
Breast cancer
+∞
9.5
9
*
130
Kela drug reimbursment
Malignant tumour
+∞
9.5
9
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
8.4
8.9
19
25
H02AB02
ATC
dexamethasone; systemic
52.8
8.8
10
*
WX140
NOMESCO Finland
Parabulbar anesthesy
9.3
8.5
17
20
C61
ICD-10 Finland
Malignant neoplasm of prostate
94.6
8.5
9
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
8.4
8
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
8.4
8
*
C50.99
ICD-10 Finland
Breast, unspecified
+∞
7.3
7
*
XCD20
NOMESCO Finland
Photoangiography of eye
9.4
7.2
14
16
HAB40
NOMESCO Finland
Wedge excision of mammary gland
72.4
6.5
7
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.9
6.4
20
45
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
6.3
6
*
116
Kela drug reimbursment
Prostate cancer
+∞
6.3
6
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
6.3
6
*
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
13.2
6.2
10
8
A03FA01
ATC
metoclopramide; systemic, rectal
3.2
6.0
31
110

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
20
42
5.20
9.30
1.3
1.2
—
—
—
0
0
109
691
2.34
7.65
7.5
3.2
13.0
11.4
umol/l
0.54
109
644
16
42
4.07
5.66
2.7
1.8
—
—
—
0
0
27
113
2.62
4.56
1.4
1.1
—
—
—
0
0
74
473
1.92
4.40
2.2
1.6
—
—
—
0
0
85
587
1.81
3.86
6.8
4.1
1.2
1.2
mmol/l
0.06
79
523
61
389
1.83
3.54
5.2
3.1
7.4
7.4
ph
0.35
16
64
27
130
2.25
3.38
2.7
1.9
4.8
6.1
umol/l
0.81
22
108
59
380
1.80
3.28
2.1
1.9
—
—
—
0
0
13
45
3.03
3.09
4.1
2.1
0.5
0.2
g/l
—
6
13
63
421
1.74
3.07
3.2
2.8
—
—
—
0
0
125
1005
1.71
3.04
4.8
3.8
—
—
—
0
0
58
381
1.75
2.99
3.5
2.8
0.1
0.5
e6/l
3.27
45
273
50
317
1.78
2.90
7.7
4.2
—
—
—
0
0
6
9
6.84
2.89
3.3
1.4
—
—
—
0
0
108
843
1.65
2.88
4.5
3.5
7.0
6.6
mmol/l
0.63
103
768
54
362
1.69
2.55
3.4
2.7
—
—
—
0
0
33
192
1.87
2.51
20.9
22.3
1.3
1.3
inr
—
5
29
92
711
1.57
2.41
3.5
3.6
0.0
0.0
estimate
0.00
18
126
58
403
1.63
2.37
2.9
3.3
—
—
—
0
0
21
106
2.10
2.36
1.1
1.2
59.2
145.7
iu/ml
—
5
46
69
502
1.59
2.33
4.4
3.4
114.6
104.1
e6/l
0.06
52
337
16
73
2.30
2.28
3.6
3.5
24.9
25.2
mmol/l
0.09
16
73
7
18
3.99
2.27
1.1
1.1
—
—
—
0
0
59
416
1.61
2.26
4.0
2.8
22.3
199.8
e6/l
0.57
47
308
13
54
2.51
2.25
2.8
3.3
—
—
—
0
0
91
714
1.52
2.16
5.0
5.0
0.0
0.0
estimate
0.00
21
122
160
1429
1.74
2.11
6.0
4.5
2.0
2.7
mu/l
0.38
149
1305
31
189
1.76
2.03
1.3
1.2
—
—
—
0
0
84
656
1.50
2.00
2.6
2.7
122.8
104.9
ug/l
0.23
78
606
91
727
1.48
1.92
3.5
3.5
0.0
0.0
estimate
0.00
20
117
62
458
1.52
1.91
2.8
1.9
59.7
57.4
u/l
0.20
62
420
14
66
2.21
1.87
6.7
4.1
1.0
1.6
%
1.67
14
66
135
1171
1.52
1.87
5.0
3.8
14.7
14.8
pmol/l
0.22
125
1067
71
544
1.49
1.83
9.5
9.8
1.1
1.3
inr
1.23
28
162
8
29
2.83
1.81
4.8
2.5
—
—
—
0
0
123
1051
1.48
1.80
3.8
3.6
—
—
—
0
0
97
795
1.45
1.74
10.9
5.6
4.1
4.1
e9/l
0.06
88
696
22
127
1.83
1.73
5.4
4.3
0.4
1.4
mmol/l
0.51
17
99
20
113
1.86
1.68
5.8
4.5
97.1
95.5
%
1.96
20
108
5
14
3.64
1.62
1.0
1.2
—
—
—
0
0
13
64
2.11
1.58
7.5
4.2
0.8
0.7
%
0.47
13
64
18
101
1.86
1.55
1.2
1.2
—
—
—
0
0
5
15
3.39
1.53
2.0
2.8
—
—
—
0
0
7
27
2.65
1.53
5.6
2.2
3.7
5.3
e9/l
—
7
27
7
27
2.65
1.53
5.6
2.9
55.7
63.3
%
—
7
27
6
21
2.92
1.52
3.3
1.3
—
—
—
0
0
74
589
1.42
1.51
4.0
4.0
35.0
103.6
ng/l
0.59
51
409
50
370
1.48
1.50
3.8
3.7
0.0
0.0
estimate
0.00
19
120
181
1712
2.09
1.49
24.6
16.7
4.5
4.5
e12/l
0.12
176
1658
181
1712
2.09
1.49
24.6
16.7
6.6
6.6
e9/l
0.03
176
1659
7
28
2.56
1.46
1.4
1.3
224.0
64.2
pmol/l
—
7
28
6
22
2.78
1.44
1.8
1.8
—
—
—
0
0
78
633
1.39
1.41
2.0
1.8
98.1
96.0
pmol/l
0.14
39
322
29
193
1.59
1.40
1.5
1.7
29.0
29.4
s
0.14
29
186
165
1527
1.59
1.39
16.8
11.3
21.1
21.2
mg/l
0.01
130
1154
130
1153
1.40
1.34
4.0
3.9
12.5
11.4
mm/h
0.34
124
1054
59
460
1.41
1.33
7.7
4.7
—
—
—
0
0
38
273
1.49
1.31
3.9
3.9
353.9
94.6
ng/l
0.59
32
207
172
1615
1.65
1.27
20.8
13.2
78.4
77.8
umol/l
0.11
172
1615
52
400
1.41
1.26
1.7
1.6
1.3
1.4
mmol/l
0.20
42
341
10
50
2.06
1.19
1.9
1.6
474.2
334.1
ug/l
—
10
43
43
324
1.42
1.17
4.7
3.6
—
—
—
0
0
7
31
2.30
1.11
4.7
2.5
8.5
8.1
kpa
—
7
31
7
31
2.30
1.11
4.7
2.5
5.2
5.0
kpa
—
7
31
43
328
1.40
1.09
3.5
3.3
—
—
—
0
0
76
638
1.32
1.05
13.0
7.8
0.0
0.0
e9/l
0.50
65
529
42
322
1.39
1.04
1.7
1.7
491.6
14440876.1
pmol/l
0.50
37
277
9
47
1.96
1.03
1.8
1.9
—
—
—
0
0
171
1619
1.54
1.01
16.6
11.0
—
—
—
0
0
85
729
1.30
0.99
6.8
4.6
0.0
0.0
e9/l
0.03
80
639
59
482
1.32
0.98
4.0
3.9
20.3
7.4
mg/mmol
0.60
39
307
172
1633
1.54
0.97
13.3
8.2
27.7
25.1
u/l
1.34
167
1567
20
134
1.55
0.96
1.5
1.4
—
—
—
0
0
86
742
1.29
0.95
7.3
4.6
1.7
1.8
e9/l
1.38
81
659
84
726
1.28
0.91
6.8
4.6
0.6
0.6
e9/l
1.12
79
633
16
103
1.60
0.91
6.4
4.2
—
—
—
0
0
13
79
1.69
0.90
2.5
3.9
—
—
—
0
0
24
171
1.46
0.88
1.6
2.0
—
—
—
0
0
20
139
1.49
0.83
1.3
1.3
—
—
—
0
0
15
98
1.58
0.81
5.0
6.6
9.8
10.0
mmol/l
0.04
15
93
58
485
1.28
0.80
3.1
2.9
6.1
7.9
mmol/l
4.06
49
415
44
358
1.30
0.75
1.5
1.3
—
—
—
0
0
43
349
1.30
0.74
2.5
2.1
2.6
3.0
mg/l
0.62
38
298
7
40
1.78
0.72
3.7
3.0
—
—
—
0
0
54
454
1.26
0.71
4.8
3.8
2.3
2.0
ug/l
0.44
48
410
54
455
1.26
0.70
3.2
3.1
113.3
194.9
mg/l
0.23
32
295
18
128
1.45
0.68
4.8
3.2
—
—
—
0
0
18
245
0.71
0.67
1.9
1.8
—
—
—
0
0
13
87
1.53
0.65
3.4
2.3
—
—
—
0
0
5
30
1.68
0.62
1.0
1.1
—
—
—
0
0
20
149
1.38
0.60
1.8
1.7
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
52
446
1.23
0.57
4.2
4.0
—
—
—
0
0
9
62
1.47
0.54
1.0
1.1
—
—
—
0
0
9
63
1.45
0.53
1.2
1.2
—
—
—
0
0
10
144
0.68
0.51
1.2
1.4
—
—
—
0
0
146
1390
1.21
0.50
16.0
11.9
40.6
40.3
%
0.13
95
1009
35
292
1.24
0.50
1.7
1.7
1385.7
1255.4
nmol/l
0.35
29
230
65
578
1.19
0.50
3.5
3.4
—
—
—
0
0
21
164
1.32
0.49
1.2
1.4
—
—
—
0
0
159
1528
1.24
0.49
5.2
4.4
6.0
5.9
mmol/l
0.24
146
1402
38
322
1.22
0.47
3.5
3.8
1.0
1.0
kg/l
—
9
46
8
118
0.66
0.47
2.3
1.4
—
—
—
0
0
7
49
1.44
0.46
1.1
1.1
—
—
—
0
0
13
96
1.38
0.43
1.4
2.4
—
—
—
0
0
18
141
1.31
0.42
1.3
1.5
—
—
—
0
0
38
327
1.20
0.41
1.4
1.3
0.5
1.5
u/ml
—
8
103
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
5
34
1.48
0.40
1.4
2.2
8.5
8.0
kpa
—
5
29
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
9
66
1.38
0.39
1.9
3.5
24.0
25.2
mmol/l
—
9
56
39
339
1.19
0.38
4.3
3.9
—
—
—
0
0
6
43
1.41
0.35
1.0
1.1
—
—
—
0
0
14
109
1.31
0.34
5.5
3.7
—
—
—
0
0
14
110
1.29
0.32
3.1
2.7
—
—
—
0
0
29
250
1.19
0.32
2.9
2.5
0.7
0.7
ug/l
0.02
20
166
153
1485
1.15
0.29
4.4
4.0
1.4
1.3
mmol/l
0.75
139
1371
10
129
0.76
0.29
1.3
1.6
—
—
—
0
0
9
75
1.21
0.25
1.6
1.3
—
—
—
0
0
10
126
0.78
0.25
1.9
1.3
—
—
—
0
0
161
1575
1.14
0.23
5.7
5.0
2.8
2.7
mmol/l
0.06
143
1464
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
5.9
—
13.1
—
0
10
19
164
1.18
0.21
2.1
2.0
103.8
119.5
ug/g
0.16
12
130
0
12
0.00
0.21
0.0
1.0
—
302.4
—
0
7
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
5
43
1.17
0.21
2.6
1.7
16.4
1.3
ug/l
—
5
37
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
10
81
1.25
0.19
2.4
1.4
1.2
1.2
g/l
—
10
76
13
109
1.21
0.19
2.9
2.9
5.3
4.2
kpa
0.74
13
102
5
66
0.75
0.17
1.2
1.1
—
—
—
0
0
24
266
0.89
0.17
1.1
1.3
28.8
13.1
u/ml
—
8
97
6
75
0.79
0.16
2.2
2.2
1.1
1.2
%
—
6
75
9
79
1.15
0.15
1.2
1.4
—
—
—
0
0
17
192
0.87
0.15
1.8
1.5
—
—
—
0
0
146
1432
1.08
0.14
6.5
5.9
40.9
40.0
mmol/mol
0.54
136
1343
14
158
0.88
0.12
1.6
1.6
—
—
—
0
0
16
143
1.13
0.12
2.1
3.3
—
—
—
0
0
11
96
1.15
0.10
3.1
3.0
5.2
5.0
kpa
0.23
11
85
5
44
1.14
0.10
1.0
1.2
—
—
—
0
0
6
55
1.09
0.09
1.0
1.3
—
—
—
0
0
6
55
1.09
0.09
1.0
1.3
—
—
—
0
0
6
55
1.09
0.09
1.0
1.3
—
—
—
0
0
6
55
1.09
0.09
1.0
1.3
—
—
—
0
0
7
66
1.06
0.08
1.0
1.7
—
—
—
0
0
6
73
0.82
0.07
2.2
2.2
0.9
0.6
%
—
6
73
7
81
0.86
0.07
5.4
3.9
—
—
—
0
0
156
1545
1.05
0.06
5.1
4.5
4.6
4.6
mmol/l
0.00
143
1448
11
100
1.11
0.05
1.0
1.2
—
—
—
0
0
10
92
1.09
0.03
2.2
1.3
—
—
—
0
0
155
1540
1.03
0.03
5.2
4.4
1.4
1.5
mmol/l
2.08
140
1435
29
283
1.03
0.01
1.8
1.3
2.2
2.5
g/l
0.34
15
172
60
594
1.01
0.00
2.8
3.0
—
—
—
0
0
11
107
1.03
0.00
2.3
1.3
66.1
67.5
g/l
0.29
11
99
28
277
1.01
0.00
1.3
1.3
36.8
43.0
iu/ml
—
9
98
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
76
0.92
0.00
1.9
1.8
—
—
—
0
0
15
150
1.00
0.00
1.5
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
7.3
—
812.7
—
0
6
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
0.00
11.0
11.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
11.7
—
0
9
5
53
0.94
0.00
1.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
5
59
0.84
0.00
1.4
1.5
0.9
1.5
g/l
—
5
52
0
7
0.00
0.00
0.0
16.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
10.0
—
1220.0
—
0
6
6
67
0.89
0.00
3.2
3.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
155.9
—
0
7
0
7
0.00
0.00
0.0
1.6
—
8.0
—
0
7
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_BENIGN_RETINA_EXALLC – Benign neoplasm: Retina

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).