Benign neoplasm: Retina

CD2_BENIGN_RETINA

retinal cancer: A malignant neoplasm involving the retina.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D31.2& Hospital discharge: ICD-9 — 2245 Hospital discharge: ICD-8 — 22404 Cause of death: ICD-10 — D31.2& Cause of death: ICD-9 — 2245 Cause of death: ICD-8 — 22404 2 out of 7 registries used, show all original rules.	198
4. Check minimum number of events None	198
5. Include endpoints None	198
6. Filter based on genotype QC (FinnGen only)	193

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D31
Name in latin: Neoplasma benignum retinae

NAME	CD2_BENIGN_RETINA
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D312
HD_ICD_9	2245
HD_ICD_8	22404
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D312
COD_ICD_9	2245
COD_ICD_8	22404
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Retina based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1303	829	465
Only index persons	1197	785	412
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.03	0.02
Median age at first event (years)
Whole population	60.48	61.23	59.15
Only index persons	60.20	61.07	58.54

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	193	113	80
Unadjusted period prevalence (%)	0.04	0.04	0.04
Median age at first event (years)	58.35	53.83	64.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
198: Matched controls
1980

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D31.2

ICD-10 Finland

Benign neoplasm: Retina

+∞

280.3

196

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

14.2

48.9

D31.3

ICD-10 Finland

Benign neoplasm: Choroid

87.3

47.9

XCK10

NOMESCO Finland

Photography of fundus of eye

9.0

43.9

109

CK2L4

NOMESCO Finland

Wide-field/panoramic imaging of ocular fundus

94.9

23.3

XCW99

NOMESCO Finland

Other investigative procedure of eye

5.8

21.6

XCD10

NOMESCO Finland

Electrophysiological examination of eye

17.1

20.2

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

5.3

18.7

102

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.8

16.3

224

Z3229

NOMESCO Finland

Other healthcare associate professional

3.8

9.8

WX140

NOMESCO Finland

Parabulbar anesthesy

4.8

8.9

CKC20

NOMESCO Finland

Cryopexy of undetached retina

52.4

8.8

XCD20

NOMESCO Finland

Photoangiography of eye

10.7

8.2

C69.30

ICD-10 Finland

Malignant tumor of the chorioidea without histology

83.1

7.5

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

115

827

1.93

4.85

7.3

6.2

12.66

10.87

umol/l

0.66

115

783

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

6.89

3.71

1.0

1.3

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

4.91

3.28

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

220

1.96

3.24

1.8

2.1

—

(3049717) Cytology report of Urine Cyto stain

2.77

3.22

2.7

2.9

—

(3035637) Corticotropin [Mass/volume] in Plasma

6.55

3.21

3.6

1.6

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

101

2.33

3.06

1.2

59.20

176.78

iu/ml

—

(3026008) Bacteria identified in Urine by Culture

482

1.66

2.80

3.2

2.9

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

655

1.59

2.56

2.4

2.2

77.13

76.02

nmol/l

0.15

578

(3037467) Urinalysis macro (dipstick) panel - Urine

130

1077

1.60

2.52

4.7

4.2

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

467

1.58

2.29

2.7

3.3

1159.95

1391.88

ng/l

0.17

387

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

764

1.53

2.26

8.2

6.3

1.22

mmol/l

0.25

652

(3035350) Ketones [Presence] in Urine by Test strip

759

1.51

2.18

3.7

3.9

0.00

estimate

-0.00

168

(3037121) Protein [Mass/volume] in Urine

2.46

2.17

4.1

3.0

0.48

0.19

g/l

—

(3030467) Casts [#/volume] in Urine by Automated count

438

1.57

2.14

3.4

3.1

0.08

0.57

e6/l

2.33

318

(3013826) Glucose [Moles/volume] in Serum or Plasma

114

939

1.50

2.10

4.4

4.2

6.90

6.64

mmol/l

0.51

109

867

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

166

1489

1.71

2.06

6.1

4.7

2.06

1.90

mu/l

0.93

155

1351

(3020891) Body temperature

2.37

2.02

2.8

3.8

—

(3021601) Nitrite [Presence] in Urine by Test strip

758

1.49

2.02

5.4

5.3

0.00

estimate

-0.00

157

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

166

1.80

2.01

2.6

3.0

4.74

8.97

umol/l

1.92

140

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.20

1.98

1.3

1.8

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.20

1.98

6.4

7.2

23.78

24.17

mmol/l

0.18

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

694

1.48

1.97

6.7

5.2

1.22

mmol/l

0.00

629

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

3.83

1.95

3.3

1.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

242

1.65

1.89

2.4

2.7

1.00

1.01

e6/l

0.01

130

(40768797) Stomach Pathology biopsy report

202

1.70

1.86

1.3

1.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

140

1219

1.51

1.85

5.1

4.0

14.63

14.82

pmol/l

0.46

130

1098

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

3.60

1.85

3.3

1.3

—

nmol/l

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

4.24

1.83

3.6

4.1

67.80

98.67

nmol/l

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

712

1.45

1.81

2.6

117.77

114.72

ug/l

0.04

654

(1616796) Gas panel - Central venous blood

2.83

1.81

4.8

3.2

—

(3009261) Glucose [Presence] in Urine by Test strip

770

1.45

1.80

3.7

3.9

0.00

estimate

-0.00

153

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

500

1.48

1.77

2.7

2.4

60.36

64.22

u/l

0.15

462

(3018418) pH of Serum or Plasma

483

1.48

1.75

5.0

3.8

7.39

7.40

0.23

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.97

1.71

3.6

4.6

24.70

24.53

mmol/l

0.07

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.97

1.71

1.5

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

652

1.44

1.70

2.0

1.8

98.01

97.40

pmol/l

0.04

334

(3026361) Erythrocytes [#/volume] in Blood

188

1772

2.21

1.68

24.7

20.4

4.50

4.48

e12/l

0.27

183

1723

(3009542) Hematocrit [Volume Fraction] of Blood

188

1772

2.21

1.68

24.6

20.4

40.63

40.24

0.44

171

1671

(3010813) Leukocytes [#/volume] in Blood

188

1772

2.21

1.68

24.7

20.5

6.68

6.69

e9/l

0.01

183

1723

(3041096) Erythrocytes [Presence] in Urine by Automated

450

1.48

1.68

3.2

3.6

—

(3044889) 12 lead EKG panel

128

1106

1.45

1.67

3.8

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

2.86

1.66

1.6

1.5

22.39

153.94

u/ml

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.14

1.64

1.7

2.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

145

1.75

1.63

1.6

1.9

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

2.56

1.61

1.9

1.8

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

269

1.56

1.61

4.0

3.4

353.88

122.36

ng/l

0.50

208

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

146

1.73

1.60

1.5

2.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

464

1.45

1.58

3.8

3.7

19.56

7.38

mg/mmol

0.60

290

(3018095) Leukocytes [#/volume] in Urine

566

1.43

1.57

4.3

3.8

108.70

61.91

e6/l

0.38

390

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

3.39

1.53

1.4

1.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

550

1.42

1.52

3.7

3.2

—

(36304419) Bacteria [Presence] in Urine

422

1.46

1.52

3.3

3.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

625

1.41

1.52

3.8

4.1

34.75

42.71

ng/l

0.25

435

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

222

1.58

1.51

3.2

2.9

3.23

2.49

e6/l

0.21

112

(36660697) Celiac disease serology panel - Serum

111

1.79

1.45

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

601

1.40

1.45

3.9

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

3.18

1.44

1.0

1.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

717

1.38

1.42

2.4

2.5

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.06

1.41

1.6

2.0

—

(40758558) Short blood count panel - Blood

401

1.44

1.40

7.4

6.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

330

1.47

1.40

3.6

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

2.99

1.36

1.0

1.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

179

1679

1.69

1.36

20.8

16.3

77.98

77.47

umol/l

0.08

179

1679

(3013707) Erythrocyte sedimentation rate by Westergren method

136

1213

1.39

1.32

4.1

3.9

12.18

12.12

mm/h

0.01

130

1099

(3022217) INR in Platelet poor plasma by Coagulation assay

725

1.36

1.30

16.2

14.2

1.15

1.25

inr

0.81

228

(3026389) Candida sp identified in Specimen by Organism specific culture

2.82

1.29

1.0

1.2

—

(3045424) Erythrocytes [Presence] in Urine

2.44

1.25

1.8

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.86

1.24

1.0

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

2.10

1.24

1.9

1.6

474.20

431.90

ug/l

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

117

1.69

1.23

7.1

2.3

52.18

66.68

ml/min/173m2

0.99

(3044640) Blood type and Crossmatch panel - Blood

493

1.38

1.23

2.0

2.2

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

339

1.42

1.22

1.6

1.8

488.41

456.04

pmol/l

0.26

289

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

179

1689

1.62

1.19

13.2

10.1

27.37

25.35

u/l

0.99

174

1626

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

172

1609

1.53

1.19

16.9

14.0

22.17

21.30

mg/l

0.14

137

1256

(3002582) Erythrocytes [#/volume] in Urine

486

1.37

1.19

3.9

3.2

21.67

170.83

e6/l

0.56

364

(3009508) Creatinine [Moles/volume] in Urine

478

1.37

1.17

3.1

2.9

6.23

7.77

mmol/l

2.64

402

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

1.17

0.0

1.2

—

4.43

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

2.54

1.16

1.4

1.1

—

(3012516) Albumin [Mass/volume] in Urine

443

1.37

1.14

3.2

3.1

112.26

190.05

mg/l

0.21

285

(40761511) CBC panel - Blood by Automated count

178

1681

1.58

1.14

16.7

13.1

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.38

1.13

5.6

2.6

55.71

63.67

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

2.38

1.13

5.6

2.0

3.67

5.65

e9/l

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

178

1.53

1.12

3.2

4.2

5.21

11.29

ug/l

0.97

147

(40768804) Tissue Pathology biopsy report

642

1.33

1.11

2.2

2.0

—

(3002256) Pathology report gross observation

196

1.50

1.10

1.4

1.2

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

429

1.36

1.07

1.7

1.6

1.33

1.35

mmol/l

0.08

358

(3042631) Mycobacterium sp identified in Specimen

2.30

1.04

2.0

3.8

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.98

0.0

1.2

—

1.20

—

(3027315) Oxygen [Partial pressure] in Blood

1.98

0.98

4.7

3.1

8.49

8.32

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

1.98

0.98

4.7

3.1

5.17

4.99

kpa

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.70

0.97

6.7

6.6

0.99

1.42

1.10

(3018677) aPTT in Platelet poor plasma by Coagulation assay

228

1.43

0.96

1.5

1.8

29.06

29.39

0.12

223

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.96

0.0

1.1

—

(3016502) Oxygen saturation in Arterial blood

144

1.51

0.92

5.7

6.3

97.20

95.85

1.84

139

(3003396) Base excess in Arterial blood by calculation

161

1.48

0.91

5.3

5.9

0.53

1.05

mmol/l

0.23

131

(4035726) Immunohistochemistry procedure

145

1.50

0.89

1.3

—

(3044290) Cell count panel - Cerebral spinal fluid

2.03

0.87

1.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

282

0.68

0.87

2.1

1.8

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

377

1.32

0.87

3.9

4.7

21.98

21.56

0.08

189

(3000991) Gas panel - Venous blood

113

1.55

0.85

6.1

6.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

165

1557

1.36

0.84

5.3

4.5

5.97

5.94

mmol/l

0.15

152

1429

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.65

0.83

3.4

2.4

—

(3015736) pH of Urine

616

1.27

0.82

3.6

5.57

5.83

—

(3007853) Bacteria identified in Skin by Aerobe culture

166

1.44

0.80

1.9

1.6

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.79

0.0

1.7

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.79

0.0

1.6

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.78

0.0

1.1

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.78

0.0

1.7

—

(3029937) Albumin [Presence] in Urine by Test strip

423

1.28

0.74

3.9

4.1

0.00

estimate

-0.00

155

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.87

0.74

1.3

1.5

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

103

927

1.23

0.73

10.7

9.0

4.22

4.06

e9/l

0.31

814

(3045414) Leukocytes [Presence] in Urine

1.61

0.72

1.8

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.57

0.71

7.5

6.6

0.82

0.70

0.51

(3006315) Basophils [#/volume] in Blood

801

1.23

0.70

6.8

5.2

0.04

e9/l

0.14

703

(3010421) pH of Blood

1.73

0.70

4.7

3.2

7.40

7.42

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.69

0.69

2.9

2.7

—

(3000492) Spirometry study

145

1.42

0.69

1.5

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

1.87

0.69

1.0

—

21.20

—

(3019060) Gas panel - Arterial blood

1.53

0.69

2.6

3.5

—

(3019309) Folate [Moles/volume] in Red Blood Cells

298

1.30

0.67

1.6

1.7

1398.97

1272.66

nmol/l

0.36

227

(3013512) EKG study

467

1.25

0.66

4.0

3.9

—

(3019150) Specific gravity of Urine by Refractometry

336

1.28

0.66

3.7

3.9

1.02

kg/l

—

(3000494) Fungus identified in Specimen by Culture

183

1.35

0.63

1.3

1.4

—

(3022621) pH of Urine by Test strip

105

1.46

0.62

2.1

2.4

—

(3001604) Monocytes [#/volume] in Blood

800

1.20

0.61

6.7

5.2

0.63

0.57

e9/l

1.09

701

(3002179) Metamyelocytes/100 leukocytes in Blood

114

1.44

0.61

2.8

5.1

0.33

0.40

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.60

0.0

1.0

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.60

0.0

1.9

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.60

0.0

1.7

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.60

0.0

1.0

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.60

0.0

4.1

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.60

0.0

1.2

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.58

0.0

1.8

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

0.58

0.0

1.9

—

(3003694) ABO and Rh group [Type] in Blood

407

1.24

0.58

1.5

1.4

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.69

0.57

1.5

1.3

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.69

0.57

1.8

1.6

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

123

0.64

0.56

2.3

1.4

—

(3034770) Mitochondria Ab [Titer] in Serum

1.60

0.55

1.7

1.1

—

(1002224) Polysomnography panel

1.45

0.53

1.0

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

750

1.18

0.52

7.7

5.7

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

180

1.31

0.52

5.5

5.7

103.43

103.92

mmol/l

0.27

180

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

394

1.22

0.51

2.5

1.9

2.62

3.04

mg/l

0.79

345

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.40

0.51

7.4

7.6

—

(3042936) Bacteria identified in Isolate by Culture

209

1.28

0.49

1.7

2.1

—

(3002032) Base excess in Venous blood by calculation

128

1.36

0.49

2.5

4.0

0.89

1.93

mmol/l

0.47

103

(21494755) Public health laboratory ask at order entry panel

154

0.70

0.49

1.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

167

1608

1.25

0.49

5.7

4.9

2.77

2.73

mmol/l

0.27

150

1475

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.54

0.49

1.1

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.51

0.48

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.51

0.48

1.1

1.2

—

(3021589) Normoblasts [#/volume] in Blood

716

1.17

0.47

13.0

9.9

0.00

e9/l

0.54

593

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

165

1.31

0.47

3.7

3.6

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

158

1516

1.21

0.46

4.4

3.9

1.37

1.27

mmol/l

0.87

144

1386

(3020779) Urea [Moles/volume] in Serum or Plasma

121

1.35

0.46

4.9

7.1

9.52

9.42

mmol/l

0.02

115

(40768793) Breast Pathology biopsy report

1.41

0.45

1.1

1.3

—

(3052851) Hemolysis interference index of Serum or Plasma

1.41

0.45

3.7

3.1

—

(3023368) Bacteria identified in Blood by Culture

409

1.20

0.45

4.6

4.4

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

1.63

0.43

1.0

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

238

0.78

0.43

1.7

1.6

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

355

1.20

0.42

1.6

1.31

1.29

mg/l

0.02

278

(3019977) pH of Arterial blood

0.00

0.41

0.0

6.3

—

7.43

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.41

0.0

2.5

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.8

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

1.44

0.39

1.2

1.9

167.60

198.93

pmol/l

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

482

1.17

0.39

4.8

5.2

2.34

3.01

ug/l

0.42

427

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

153

1472

1.17

0.38

6.4

5.8

40.64

40.04

mmol/mol

0.32

143

1376

(3048689) Calprotectin [Mass/mass] in Stool

180

1.25

0.38

2.0

1.9

97.24

127.88

ug/g

0.35

143

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.35

0.36

3.2

3.4

-0.77

1.50

mmol/l

—

(40761535) Cells panel - Urine sediment

117

1.31

0.36

3.6

3.4

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

0.63

0.36

1.4

2.1

0.88

1.59

g/l

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.44

0.36

1.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.44

0.36

2.0

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

362

1.17

0.34

2.1

2.2

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.34

0.34

1.0

1.1

—

(3043409) Potassium [Moles/volume] in Arterial blood

1.34

0.34

3.0

4.00

3.99

mmol/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.34

0.32

1.3

1.2

—

(3019225) pH of Specimen

148

1.24

0.30

4.8

4.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

161

1565

1.15

0.29

5.2

4.4

1.40

1.48

mmol/l

1.72

146

1441

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.24

0.29

3.0

5.1

1.84

1.49

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

162

1576

1.15

0.29

5.1

4.4

4.68

4.63

mmol/l

0.23

149

1464

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

103

1.28

0.29

1.5

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

159

1.22

0.28

1.3

1.5

—

(3017181) Myelocytes/100 leukocytes in Blood

132

1.23

0.26

3.1

5.0

0.83

0.90

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

170

0.81

0.26

1.7

1.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

361

1.14

0.25

1.4

1.2

0.53

1.21

u/ml

—

109

(4200892) Spirometry reversibility

126

0.78

0.25

1.9

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

285

1.15

0.24

1.3

1.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.71

0.24

2.0

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

189

0.83

0.23

1.6

1.5

—

(3024354) Oxygen [Partial pressure] in Venous blood

116

1.22

0.22

3.2

2.8

5.33

4.18

kpa

0.84

111

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.23

0.22

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.21

0.0

1.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.4

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

2.5

—

11.48

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.21

0.0

1.5

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

18.9

—

765.50

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

23.5

—

1167.80

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

185.98

—

(3022145) Colonoscopy Study observation

183

1.17

0.21

1.3

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.21

0.0

3.5

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

1.3

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.26

0.20

5.0

2.4

1.33

1.60

mg/l

—

(43055225) Phosphorylated tau 181 [Mass/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.20

0.0

1.0

—

42.50

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.20

0.0

1.2

—

(3042810) Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid

0.00

0.20

0.0

1.0

—

444.56

—

(3000242) Tau protein [Mass/volume] in Cerebral spinal fluid

0.00

0.20

0.0

1.0

—

295.88

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

185

0.85

0.19

9.8

7.6

—

(4034850) Laboratory test

1.14

0.19

11.0

11.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

262

1.13

0.18

1.3

36.78

37.62

iu/ml

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.15

0.17

1.0

1.8

9.77

10.00

g/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

141

0.84

0.17

1.5

1.7

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.13

0.16

1.0

1.6

—

(3000330) Specific gravity of Urine by Test strip

1.10

0.16

5.1

4.0

—

(40768443) Skin Pathology biopsy report

1.16

0.15

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

160

0.87

0.14

1.5

1.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

105

1019

1.06

0.14

3.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.18

0.13

1.0

1.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.14

0.10

1.4

1.3

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

1.11

0.10

3.6

3.8

—

3.60

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

206

0.91

0.09

4.7

4.4

31.15

31.63

0.06

135

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

154

1520

1.06

0.09

17.7

13.2

79.53

80.78

ml/min/173m2

0.26

130

1240

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.11

0.09

2.2

2.0

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.78

0.08

1.4

1.8

0.88

2.80

mg/l

—

(3008898) HLA-B27 [Presence]

1.08

0.08

1.1

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.06

0.08

1.0

1.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

326

0.94

0.07

1.8

1.3

2.14

2.45

g/l

0.31

201

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

178

1.07

0.06

3.4

3.9

271.21

246.50

u/l

0.66

170

(3021879) Hepatitis B virus core Ab [Presence] in Serum

110

0.90

0.05

1.3

1.5

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

278

1.05

0.05

2.9

3.1

0.73

0.77

ug/l

0.20

187

(3025941) Bacteria identified in Stool by Culture

1.10

0.04

1.5

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

103

1.07

0.02

2.1

2.3

—

(3028026) IgM [Mass/volume] in Serum or Plasma

106

0.94

0.01

2.4

1.5

1.19

1.23

g/l

—

(40761536) Microorganisms panel - Urine sediment

134

1.05

0.00

5.5

4.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

176

0.96

0.00

2.1

2.0

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

254

0.98

0.00

1.2

1.3

25.67

7.96

u/ml

—

(1761868) Lipid panel - Serum or Plasma

618

1.00

0.00

2.8

2.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

163

0.98

0.00

2.2

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

295

0.98

0.00

1.5

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

129.33

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.9

—

34675.63

—

(3027008) Opiates [Presence] in Urine

0.95

-0.00

1.0

1.3

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3020630) Protein [Mass/volume] in Serum or Plasma

120

1.00

-0.00

2.2

2.5

65.70

66.63

g/l

0.20

108

(3027944) Amphetamines [Presence] in Urine

0.95

-0.00

1.0

1.3

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(40758292) HTLV I+II Ab panel - Serum

0.00

-0.00

0.0

1.7

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

1351.50

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.99

-0.00

1.8

1.6

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.88

-0.00

1.3

1.6

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

-0.00

0.0

16.0

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

2.9

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

(3020229) Cytomegalovirus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

0.95

-0.00

1.0

1.3

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.5

—

(3024263) Appearance of Synovial fluid

0.00

-0.00

0.0

1.3

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

-0.00

0.0

1.8

—

152.50

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

8.47

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

-0.00

0.0

1.4

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

2.8

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.5

—

(3022313) Gas panel - Capillary blood

1.00

-0.00

3.4

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

3.4

—

(3028300) Cannabinoids [Presence] in Urine

0.95

-0.00

1.0

1.3

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.6

—

(3016879) Cocaine [Presence] in Urine

0.84

-0.00

1.0

1.3

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.91

-0.00

2.3

1.9

13.80

4.85

ug/l

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.98

-0.00

1.0

1.2

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.1

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.3

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

7.21

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.3

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.2

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.3

—

(3017704) Immunofixation for Urine

0.00

-0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_RETINA and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_RETINA	1.033 [0.85, 1.25]	0.737
Birth year	0.994 [0.98, 1.0]	0.155

During the follow-up period (1.1.1998 — 31.12.2019), 140 out of 738 females with CD2_BENIGN_RETINA died.

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_RETINA	0.984 [0.75, 1.29]	0.909
Birth year	0.989 [0.98, 1.0]	0.021

During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 406 males with CD2_BENIGN_RETINA died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_RETINA.

N-year risk	Females	Males
1	0.112%	0.176%
5	0.644%	1.224%
10	1.531%	2.973%
15	2.774%	5.538%
20	4.867%	9.406%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_RETINA – Benign neoplasm: Retina

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Retina

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints