Benign neoplasm: Retina

CD2_BENIGN_RETINA

retinal cancer: A malignant neoplasm involving the retina.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D31.2& Hospital discharge: ICD-9 — 2245 Hospital discharge: ICD-8 — 22404 Cause of death: ICD-10 — D31.2& Cause of death: ICD-9 — 2245 Cause of death: ICD-8 — 22404 2 out of 7 registries used, show all original rules.	191
4. Check minimum number of events None	191
5. Include endpoints None	191
6. Filter based on genotype QC (FinnGen only)	191

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D31
Name in latin: Neoplasma benignum retinae

NAME	CD2_BENIGN_RETINA
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D312
HD_ICD_9	2245
HD_ICD_8	22404
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D312
COD_ICD_9	2245
COD_ICD_8	22404
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Benign neoplasm: Retina based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Benign neoplasm: Retina

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1303	829	465
Only index persons	1197	785	412
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.03	0.02
Median age at first event (years)
Whole population	60.48	61.23	59.15
Only index persons	60.20	61.07	58.54

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	191	111	80
Unadjusted period prevalence (%)	0.04	0.04	0.04
Median age at first event (years)	57.72	52.66	64.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
165: Matched controls
1647

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D31.2

ICD-10 Finland

Benign neoplasm: Retina

+∞

232.5

163

D31.3

ICD-10 Finland

Benign neoplasm: Choroid

47.8

35.9

XCK10

NOMESCO Finland

Photography of fundus of eye

10.2

27.8

CK2L4

NOMESCO Finland

Wide-field/panoramic imaging of ocular fundus

47.8

17.8

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

9.3

16.8

XCD10

NOMESCO Finland

Electrophysiological examination of eye

13.8

15.8

Z01.0

ICD-10 Finland

Examination of eyes and vision

5.0

15.1

150

XCW99

NOMESCO Finland

Other investigative procedure of eye

5.1

11.7

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

5.5

10.8

CKC20

NOMESCO Finland

Cryopexy of undetached retina

+∞

10.5

XCD20

NOMESCO Finland

Photoangiography of eye

25.3

10.4

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

109

802

1.84

4.08

7.5

6.3

13.0

10.9

umol/l

0.77

109

760

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

7.53

3.90

1.0

1.3

—

(3049717) Cytology report of Urine Cyto stain

2.77

3.22

2.7

2.9

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

2.39

3.09

1.1

1.2

59.2

181.8

iu/ml

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

214

1.90

2.86

1.7

2.1

—

(3022217) INR in Platelet poor plasma by Coagulation assay

184

1.96

2.84

20.9

23.7

1.3

inr

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

4.35

2.71

1.0

1.1

—

(3035637) Corticotropin [Mass/volume] in Plasma

5.59

2.56

3.3

1.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

125

1039

1.59

2.36

4.8

4.3

—

(3026008) Bacteria identified in Urine by Culture

451

1.59

2.27

3.2

3.0

—

(3037121) Protein [Mass/volume] in Urine

2.46

2.17

4.1

3.0

0.5

0.2

g/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

457

1.56

2.13

2.8

3.3

1172.5

1410.4

ng/l

0.17

379

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.27

2.11

1.3

1.8

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

634

1.51

2.07

2.4

2.2

76.7

76.1

nmol/l

0.08

558

(3035350) Ketones [Presence] in Urine by Test strip

730

1.50

2.04

3.5

3.8

0.0

estimate

0.00

154

(3020891) Body temperature

2.37

2.02

2.8

3.8

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

160

1434

1.71

2.02

6.0

4.6

2.0

1.9

mu/l

0.79

149

1299

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

3.83

1.95

3.3

1.3

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

160

1.80

1.95

2.7

3.1

4.8

9.1

umol/l

1.86

136

(3030467) Casts [#/volume] in Urine by Automated count

424

1.53

1.87

3.5

3.1

0.1

0.6

e6/l

2.48

307

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

3.61

1.85

3.3

1.3

—

nmol/l

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

741

1.47

1.84

8.3

6.3

1.2

mmol/l

0.25

625

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

4.25

1.83

3.6

4.1

67.8

98.7

nmol/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

732

1.46

1.83

5.0

5.2

0.0

estimate

0.00

153

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

675

1.47

1.83

6.8

5.2

1.2

mmol/l

0.00

609

(1616796) Gas panel - Central venous blood

2.83

1.81

4.8

3.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

135

1175

1.51

1.80

5.0

4.0

14.7

14.8

pmol/l

0.34

125

1059

(40768797) Stomach Pathology biopsy report

196

1.69

1.80

1.3

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

431

1.50

1.72

2.9

3.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.98

1.71

1.5

1.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

108

908

1.44

1.67

4.5

4.2

7.0

6.7

mmol/l

0.62

103

837

(3009261) Glucose [Presence] in Urine by Test strip

743

1.43

1.64

3.5

3.9

0.0

estimate

0.00

148

(3001122) Ferritin [Mass/volume] in Serum or Plasma

677

1.43

1.62

2.6

122.8

116.9

ug/l

0.07

622

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

2.56

1.61

1.9

1.8

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

262

1.56

1.58

3.9

3.3

353.9

89.8

ng/l

0.60

202

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

3.39

1.53

1.0

1.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

3.39

1.53

1.4

1.1

—

(3026361) Erythrocytes [#/volume] in Blood

181

1710

2.12

1.53

24.6

20.7

4.5

e12/l

0.32

176

1663

(3010813) Leukocytes [#/volume] in Blood

181

1710

2.12

1.53

24.6

20.7

6.6

6.7

e9/l

0.08

176

1663

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.14

1.52

1.6

2.0

—

(3018418) pH of Serum or Plasma

468

1.45

1.52

5.2

3.8

7.4

0.23

(3044889) 12 lead EKG panel

123

1069

1.42

1.52

3.8

3.9

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.92

1.51

3.6

4.7

24.9

24.6

mmol/l

0.16

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

141

1.72

1.50

1.5

2.0

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

142

1.70

1.46

1.5

2.0

—

(36304419) Bacteria [Presence] in Urine

408

1.45

3.4

3.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

3.18

1.44

1.0

1.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

454

1.43

1.44

4.0

3.9

20.3

7.5

mg/mmol

0.60

283

(3018095) Leukocytes [#/volume] in Urine

547

1.41

1.43

4.4

3.8

114.6

63.7

e6/l

0.39

378

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

234

1.55

1.42

2.6

2.7

1.0

e6/l

0.00

125

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.47

1.40

5.6

2.7

55.7

64.0

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

2.47

1.40

5.6

2.1

3.7

5.7

e9/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

531

1.40

1.38

3.9

3.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

579

1.39

1.36

3.6

3.9

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

486

1.41

1.36

2.8

2.4

59.7

55.0

u/l

0.52

448

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.03

1.36

1.6

2.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

638

1.38

1.33

2.0

1.8

98.1

97.4

pmol/l

0.04

327

(36660697) Celiac disease serology panel - Serum

107

1.75

1.31

1.2

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

2.14

1.30

1.9

1.6

474.2

440.3

ug/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

319

1.45

1.27

3.5

3.6

—

(3045424) Erythrocytes [Presence] in Urine

2.44

1.25

1.8

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

216

1.52

1.24

3.3

2.9

3.3

2.4

e6/l

0.24

109

(40758558) Short blood count panel - Blood

386

1.40

1.19

7.7

6.6

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

1.17

0.0

1.2

—

4.4

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

172

1621

1.61

1.17

20.8

16.6

78.4

77.8

umol/l

0.11

172

1621

(3002582) Erythrocytes [#/volume] in Urine

472

1.36

1.13

4.0

3.2

22.3

175.8

e6/l

0.56

353

(3009508) Creatinine [Moles/volume] in Urine

463

1.36

1.13

3.1

2.9

6.1

7.8

mmol/l

3.49

385

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

614

1.34

1.12

4.0

4.1

35.0

42.4

ng/l

0.22

428

(3002256) Pathology report gross observation

187

1.52

1.11

1.4

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.81

1.10

1.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

693

1.32

1.08

4.0

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

114

1.64

1.07

7.4

2.3

52.2

66.9

ml/min/173m2

1.01

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.74

1.04

6.7

6.5

1.0

1.4

1.16

(3042631) Mycobacterium sp identified in Specimen

2.31

1.04

2.0

3.9

—

(3044640) Blood type and Crossmatch panel - Blood

478

1.34

1.04

2.1

2.2

—

(3012516) Albumin [Mass/volume] in Urine

432

1.35

1.03

3.2

3.1

113.3

195.6

mg/l

0.21

276

(3013707) Erythrocyte sedimentation rate by Westergren method

130

1178

1.32

1.01

4.0

12.5

12.2

mm/h

0.07

124

1066

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

165

1552

1.46

1.01

16.8

14.2

21.1

21.5

mg/l

0.06

130

1216

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

172

1631

1.55

1.01

13.3

10.2

27.7

25.4

u/l

1.14

167

1572

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

415

1.35

1.01

1.7

1.6

1.3

1.4

mmol/l

0.12

346

(40768804) Tissue Pathology biopsy report

623

1.31

0.99

2.2

2.1

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.98

0.0

1.2

—

1.2

—

(3013290) Carbon dioxide [Partial pressure] in Blood

1.98

0.98

4.7

3.1

5.2

5.0

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

1.98

0.98

4.7

3.1

8.5

8.3

kpa

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.97

0.0

1.1

—

(40761511) CBC panel - Blood by Automated count

171

1624

1.51

0.94

16.6

13.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.69

0.90

3.4

2.4

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

330

1.35

0.90

1.7

1.8

491.6

453.9

pmol/l

0.30

281

(46235355) HIV 1 and 2 tests - Meaningful Use set

260

0.66

0.89

1.9

1.8

—

(3003396) Base excess in Arterial blood by calculation

154

1.48

0.88

5.4

5.9

0.4

1.1

mmol/l

0.32

123

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

377

1.33

0.88

3.9

4.7

22.0

21.6

0.08

189

(3016502) Oxygen saturation in Arterial blood

138

1.50

0.86

5.8

6.3

97.1

95.8

1.68

133

(3000492) Spirometry study

139

1.49

0.83

1.5

—

(3029937) Albumin [Presence] in Urine by Test strip

408

1.31

0.83

3.8

4.1

0.0

estimate

0.00

151

(3032080) INR in Blood by Coagulation assay

608

1.27

0.81

9.5

1.1

1.2

inr

0.63

196

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.79

0.0

1.7

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.79

0.0

1.8

—

(4035726)

141

1.47

0.78

1.3

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.78

0.0

1.1

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

220

1.38

0.77

1.5

1.8

29.0

29.3

0.09

215

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.61

0.77

7.5

6.6

0.8

0.7

0.54

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.79

0.77

1.8

1.6

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.87

0.74

1.3

1.5

—

(3045414) Leukocytes [Presence] in Urine

1.64

0.73

1.8

—

(3010421) pH of Blood

1.73

0.70

4.7

3.2

7.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

159

1509

1.32

0.70

5.2

4.5

6.0

mmol/l

0.21

146

1386

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.69

0.69

2.9

2.7

—

(3000991) Gas panel - Venous blood

111

1.48

0.68

6.4

6.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

146

1373

1.27

0.68

16.0

14.6

40.6

39.9

0.40

1004

(42529406) Shigella sp [Presence] in Stool by Culture

1.61

0.66

1.1

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.61

0.66

1.1

1.2

—

(3044290) Cell count panel - Cerebral spinal fluid

1.74

0.64

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.60

0.0

1.0

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.60

0.0

1.1

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.60

0.0

1.7

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.60

0.0

4.1

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.60

0.0

1.2

—

(42870588) Differential panel, method unspecified - Blood

511

1.22

0.59

7.7

4.8

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.59

0.0

1.9

—

(4268621)

0.00

0.58

0.0

1.9

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.58

0.0

1.7

—

(3034770) Mitochondria Ab [Titer] in Serum

1.74

0.58

1.7

1.1

—

(1002224) Polysomnography panel

1.55

0.56

1.0

1.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.60

0.55

2.0

1.6

—

(3019060) Gas panel - Arterial blood

1.46

0.54

2.5

3.5

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.45

0.53

1.9

4.3

24.0

24.2

mmol/l

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.58

0.49

1.1

1.2

—

(3019309) Folate [Moles/volume] in Red Blood Cells

293

1.24

0.48

1.7

1385.7

1256.5

nmol/l

0.35

224

(3013650) Neutrophils [#/volume] in Blood by Automated count

894

1.17

0.48

10.9

9.0

4.1

e9/l

0.13

787

(21494755) Public health laboratory ask at order entry panel

142

0.69

0.48

1.2

1.4

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

117

0.67

0.47

2.3

1.4

—

(3052851) Hemolysis interference index of Serum or Plasma

1.48

0.47

3.7

3.2

—

(3006315) Basophils [#/volume] in Blood

777

1.17

0.46

6.8

5.2

0.0

e9/l

0.13

679

(40768793) Breast Pathology biopsy report

1.44

0.46

1.1

1.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

153

1467

1.22

0.46

4.4

4.0

1.4

1.3

mmol/l

0.82

139

1341

(3019150) Specific gravity of Urine by Refractometry

323

1.22

0.46

3.5

3.9

1.0

kg/l

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

175

1.29

0.46

5.5

5.8

103.4

103.8

mmol/l

0.23

169

(3021589) Normoblasts [#/volume] in Blood

690

1.17

0.45

13.0

10.0

0.0

e9/l

0.54

569

(3019198) Lymphocytes [#/volume] in Blood

790

1.16

0.44

7.3

5.3

1.7

2.0

e9/l

1.31

705

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

161

1554

1.23

0.43

5.7

4.9

2.8

2.7

mmol/l

0.14

143

1424

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

269

1.23

0.43

1.3

1.4

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

1.63

0.43

1.0

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

216

0.77

0.43

1.8

1.6

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.42

0.41

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(3019977) pH of Arterial blood

0.00

0.41

0.0

6.3

—

7.4

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.41

0.0

2.5

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.8

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.41

0.0

2.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

160

1.28

0.40

1.8

1.6

—

(3003694) ABO and Rh group [Type] in Blood

385

1.19

0.40

1.5

1.4

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.40

0.0

1.2

—

(3013512) EKG study

462

1.17

0.40

4.2

3.9

—

(3001604) Monocytes [#/volume] in Blood

775

1.15

0.39

6.8

5.2

0.6

e9/l

1.11

674

(3028626) Oxygen [Partial pressure] in Capillary blood

1.44

0.39

1.4

2.5

8.5

8.2

kpa

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

1.44

0.39

1.2

1.9

167.6

198.9

pmol/l

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.44

0.39

1.4

1.3

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

482

1.17

0.39

4.8

5.2

2.3

3.0

ug/l

0.42

427

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

377

1.18

0.38

2.5

1.9

2.6

3.1

mg/l

0.85

331

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

162

1.26

0.37

3.8

3.6

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

0.64

0.36

1.4

2.1

0.9

1.6

g/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

145

1.27

0.35

1.3

1.5

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.38

0.34

1.0

1.1

—

(3043409) Potassium [Moles/volume] in Arterial blood

1.34

0.34

3.0

4.0

mmol/l

—

(3019225) pH of Specimen

146

1.26

0.33

4.8

4.3

—

(3020779) Urea [Moles/volume] in Serum or Plasma

119

1.28

0.33

5.0

7.2

9.8

9.5

mmol/l

0.08

113

(3022621) pH of Urine by Test strip

101

1.31

0.32

1.4

2.4

—

(40761535) Cells panel - Urine sediment

111

1.28

0.31

3.1

3.4

—

(3042936) Bacteria identified in Isolate by Culture

204

1.20

0.30

1.6

2.1

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

162

0.79

0.29

1.8

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.30

0.28

7.9

7.5

—

(3012544) pH of Venous blood

131

1.24

0.28

2.1

4.0

—

(3000494) Fungus identified in Specimen by Culture

178

1.20

0.27

1.2

1.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.67

0.26

2.2

1.8

—

(40768443) Skin Pathology biopsy report

1.21

0.25

1.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

179

0.82

0.24

10.2

7.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

354

1.13

0.23

2.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.27

0.23

1.0

1.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.29

0.23

1.0

1.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.23

0.22

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

177

0.83

0.22

1.5

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

156

1525

1.13

0.21

5.1

4.4

4.6

mmol/l

0.07

143

1416

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.20

0.21

1.0

1.2

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

2.5

—

11.5

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.4

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.21

0.0

1.5

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3000012) Reticulocyte production index

0.00

0.21

0.0

1.5

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.21

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

155

1515

1.12

0.21

5.2

4.4

1.4

1.5

mmol/l

1.91

140

1394

(3051651) Icteric interference index of Serum or Plasma

0.00

0.21

0.0

3.5

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

123

0.80

0.21

1.3

1.6

—

(43055225) Phosphorylated tau 181 [Mass/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.21

0.0

1.0

—

45.4

—

(3042810) Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

466.9

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3000242) Tau protein [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

302.4

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.21

0.0

1.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

347

1.12

0.20

1.4

1.2

0.6

1.2

u/ml

—

106

(40760892) CBC W Ordered Manual Differential panel - Blood

357

1.12

0.20

4.3

4.9

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.18

0.19

2.2

2.1

—

(3023368) Bacteria identified in Blood by Culture

397

1.11

0.19

4.7

4.5

—

(3000764) Benzodiazepines [Presence] in Urine

1.16

0.19

1.0

1.3

—

(3028300) Cannabinoids [Presence] in Urine

1.16

0.19

1.0

1.3

—

(3027944) Amphetamines [Presence] in Urine

1.16

0.19

1.0

1.3

—

(3027008) Opiates [Presence] in Urine

1.16

0.19

1.0

1.3

—

(4034850)

1.14

0.19

11.0

11.4

—

(4010399)

121

0.82

0.18

1.9

1.4

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.17

0.18

1.0

1.8

9.8

10.0

g/l

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

146

1428

1.10

0.17

6.5

5.9

40.9

40.1

mmol/mol

0.46

136

1337

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

255

1.11

0.16

1.3

36.8

38.5

iu/ml

—

(3007164) IgA [Mass/volume] in Serum or Plasma

316

0.90

0.15

1.8

1.3

2.2

2.5

g/l

0.30

194

(3022145) Colonoscopy Study observation

179

1.13

0.15

1.3

—

(3024354) Oxygen [Partial pressure] in Venous blood

113

1.16

0.13

2.9

5.3

4.2

kpa

0.71

108

(3021879) Hepatitis B virus core Ab [Presence] in Serum

105

0.85

0.13

1.2

1.5

—

(3048689) Calprotectin [Mass/mass] in Stool

172

1.12

0.12

2.1

2.0

103.8

131.1

ug/g

0.27

138

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

1.11

0.10

3.6

3.8

—

3.6

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.04

0.09

5.8

2.4

1.4

1.6

mg/l

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.14

0.09

3.1

3.2

5.2

5.0

kpa

0.31

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

968

1.05

0.09

3.1

3.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

154

0.90

0.08

1.6

—

(3008898) HLA-B27 [Presence]

0.80

0.08

1.2

1.1

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.78

0.08

2.6

1.9

16.4

5.0

ug/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.08

0.08

1.0

1.8

—

(3022313) Gas panel - Capillary blood

0.85

0.08

3.2

3.4

—

(3025941) Bacteria identified in Stool by Culture

1.05

0.07

1.6

1.3

—

(40761536) Microorganisms panel - Urine sediment

128

1.10

0.07

5.5

4.2

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

203

0.93

0.06

4.7

4.5

31.2

31.4

0.03

131

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

148

1466

1.04

0.05

17.8

13.4

78.7

80.3

ml/min/173m2

0.37

124

1189

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

278

1.05

0.05

2.9

3.1

0.7

0.8

ug/l

0.20

187

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

102

1.08

0.03

1.6

—

(3020630) Protein [Mass/volume] in Serum or Plasma

118

0.93

0.03

2.3

2.5

66.1

66.6

g/l

0.10

106

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

157

0.95

0.01

1.9

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

174

1.04

0.00

3.6

4.0

267.0

247.6

u/l

0.46

166

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

246

0.97

0.00

1.1

1.3

28.8

8.1

u/ml

—

(1761868) Lipid panel - Serum or Plasma

594

1.01

0.00

2.8

3.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

103

0.97

0.00

2.2

2.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

275

0.98

0.00

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

145

0.96

0.00

1.9

1.8

—

(3028026) IgM [Mass/volume] in Serum or Plasma

105

0.95

0.00

2.4

1.5

1.2

g/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.89

0.00

1.9

1.6

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.2

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.1

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

3.4

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.0

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3016879) Cocaine [Presence] in Urine

1.02

0.00

1.0

1.3

—

(3027300) Silver Birch IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.00

0.00

1.0

1.6

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.5

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

1351.5

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

19.7

—

1143.7

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.7

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

0.0

1.0

—

154.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.84

0.00

1.4

1.5

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

0.94

0.00

2.2

5.3

1.9

1.5

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

1.4

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.89

0.00

1.0

1.8

38.7

37.7

g/l

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.5

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

16.0

—

(3000330) Specific gravity of Urine by Test strip

1.00

0.00

5.4

4.0

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.98

0.00

1.0

1.8

3.1

g/l

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.3

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

2.8

—

(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood

0.00

0.0

1.0

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

7.2

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

2.1

—

(3020229) Cytomegalovirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.3

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.2

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.6

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.6

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

14.7

—

766.0

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

0.0

1.7

—

8.7

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.2

—

(3017704) Immunofixation for Urine

0.00

0.0

1.4

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

3.1

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.6

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

129.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_RETINA and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_RETINA	1.033 [0.85, 1.25]	0.737
Birth year	0.994 [0.98, 1.0]	0.155

During the follow-up period (1.1.1998 — 31.12.2019), 140 out of 738 females with CD2_BENIGN_RETINA died.

Males

Parameter	HR [95% CI]	p-value
CD2_BENIGN_RETINA	0.984 [0.75, 1.29]	0.909
Birth year	0.989 [0.98, 1.0]	0.021

During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 406 males with CD2_BENIGN_RETINA died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_RETINA.

N-year risk	Females	Males
1	0.112%	0.176%
5	0.644%	1.224%
10	1.531%	2.973%
15	2.774%	5.538%
20	4.867%	9.406%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_RETINA – Benign neoplasm: Retina

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Benign neoplasm: Retina

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints