This is a non-core endpoint: only basic statistics are computed.
Carcinoma in situ of breast
CD2_INSITU_BREAST
breast ductal carcinoma in situ: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleonly females |
293218 |
2. Check conditions
|
268223 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
203 |
6. Filter based on genotype QC (FinnGen only) |
194 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF9
- Parent code in ICD-10
- D00-D09
- Name in latin
- Carcinoma in situ vulvae
Similar endpoints
↥List of similar endpoints to
Carcinoma in situ of breast
based on the number of shared cases.
Similar with more cases:
- In situ neoplasms
- Neoplasms
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 194 | 194 | - |
| Unadjusted period prevalence (%) | 0.07 | 0.07 | - |
| Median age at first event (years) | 62.87 | 62.87 | - |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 203
- Matched controls
- 2030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
263.4
312.3
162
30
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
24.9
110.0
94
68
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
16.4
84.2
91
96
PJA12
NOMESCO Finland
Sentinel node biopsy
8.1
46.1
84
162
HAB50
NOMESCO Finland
Partial excision of mammary gland with reconstructive operation
12.5
43.6
48
49
WX402
NOMESCO Finland
General anaesthesia
5.9
35.3
100
286
D05.9
ICD-10 Finland
Carcinoma in situ of breast, unspecified
380.9
32.9
32
*
HAB99
NOMESCO Finland
Other partial excision of mammary gland
11.9
32.8
36
36
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
10.5
29.9
36
41
HAB40
NOMESCO Finland
Wedge excision of mammary gland
7.1
29.1
51
91
HA1AA
NOMESCO Finland
X-ray mammography
5.5
25.2
61
147
D05.0
ICD-10 Finland
Lobular carcinoma in situ
141.7
24.2
25
*
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
8.3
21.8
31
43
XX2RW, ,
NOMESCO Finland
47.2
21.0
25
6
WZC00
NOMESCO Finland
Treatment plan or consultation
3.8
19.7
116
528
HA4ST
NOMESCO Finland
Labeling mammary gland pathology with sterotactic guidance
61.3
19.3
22
*
XX3DW
NOMESCO Finland
Time consuming IT work
4.2
15.6
50
147
WZC15, ,
NOMESCO Finland
61.5
15.0
17
*
N64.5
ICD-10 Finland
Other signs and symptoms in breast
6.5
14.4
25
43
WZC30
NOMESCO Finland
Teaching
3.6
13.9
57
198
D48.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Breast
13.5
13.5
23
19
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
4.0
12.9
42
124
N63
ICD-10 Finland
Unspecified lump in breast
4.0
12.1
39
114
XX3AT
NOMESCO Finland
Other labeling with ultrasound guidance
69.1
11.7
13
*
HA1S1
NOMESCO Finland
Photography of breasts
+∞
11.6
11
*
HA3ST
NOMESCO Finland
Removal of lesion of breast with radiological guidance
46.0
11.1
13
*
HA1RA, ,
SPAT
4.6
11.0
28
68
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
5.4
9.8
20
40
HA1AT
NOMESCO Finland
Biopsy of mammary glands with ultrasound guidance
7.9
9.5
21
29
HA1BG
NOMESCO Finland
MRI examination of mammary gland with high intensity magnet
10.8
9.2
17
17
HAD30
NOMESCO Finland
Reduction mammoplasty with transposition of areola
4.7
9.1
22
51
HAB00
NOMESCO Finland
Excision of lesion of mammary gland
4.7
8.4
20
46
115
Kela drug reimbursment
Breast cancer
0.0
7.7
*
184
XX1XN
NOMESCO Finland
Other isotope examination
10.6
7.7
14
14
HA6HA
NOMESCO Finland
Tomosynthesis assessment of mammary gland specimen
31.2
7.2
9
*
D24
ICD-10 Finland
Benign neoplasm of breast
6.5
6.9
17
28
H03BB01
ATC
carbimazole; oral
4.0
6.2
18
48
N64.9
ICD-10 Finland
Disorder of breast, unspecified
13.1
6.1
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
16
51
3.32
4.31
1.2
1.7
3.58
8.34
iu/l
—
6
20
107
783
1.78
3.92
2.1
2.3
—
—
—
0
0
59
383
1.76
3.15
1.8
2.0
—
—
—
0
0
185
1674
2.19
2.65
10.3
11.1
81.60
82.33
ml/min/173m2
0.20
142
1379
196
1848
2.76
2.29
12.9
13.9
67.86
68.11
umol/l
0.06
196
1848
156
1363
1.62
2.22
6.6
6.8
73.35
77.21
u/l
0.84
150
1263
6
15
4.09
2.05
2.8
1.8
1.58
3.49
nmol/l
—
6
15
7
25
2.86
1.66
1.0
1.2
—
—
—
0
0
7
25
2.86
1.66
1.0
1.2
—
—
—
0
0
7
25
2.86
1.66
1.0
1.2
—
—
—
0
0
7
26
2.75
1.59
1.3
1.2
—
—
—
0
0
7
26
2.75
1.59
1.3
1.2
—
—
—
0
0
7
26
2.75
1.59
1.3
1.2
—
—
—
0
0
117
1002
1.40
1.53
6.2
8.5
3.83
3.82
e9/l
0.03
102
878
54
406
1.45
1.48
1.4
1.6
0.60
0.86
mg/l
1.06
39
328
91
758
1.36
1.36
5.6
4.9
1.21
1.23
mmol/l
0.94
83
690
74
606
1.35
1.21
2.7
3.3
2.35
2.37
mmol/l
0.49
64
541
6
26
2.35
1.19
3.8
4.0
58.17
61.77
%
—
6
26
0
34
0.00
1.17
0.0
1.0
—
2.14
—
0
16
57
452
1.36
1.14
1.4
1.5
—
—
—
0
0
83
700
1.31
1.09
4.5
3.6
36.64
36.20
g/l
0.35
78
659
97
837
1.30
1.08
7.2
5.8
1.21
1.23
mmol/l
1.00
81
714
41
312
1.39
1.05
2.9
2.4
2.43
2.45
mmol/l
1.03
34
275
7
34
2.10
1.04
1.6
1.4
—
—
—
0
0
9
47
1.96
1.03
1.2
1.2
—
—
—
0
0
29
389
0.70
0.96
1.3
1.3
6.88
12.32
u/ml
0.38
12
167
12
71
1.73
0.91
4.8
8.1
96.65
94.08
%
2.38
12
71
157
1463
1.32
0.89
6.0
4.4
14.96
14.61
pmol/l
1.02
145
1341
146
1352
1.28
0.84
3.9
4.1
11.42
11.21
mm/h
0.08
134
1247
8
48
1.69
0.79
1.3
1.3
—
—
—
0
0
8
48
1.69
0.79
1.1
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.3
—
—
—
0
0
0
25
0.00
0.79
0.0
1.3
—
—
—
0
0
181
1732
1.42
0.78
4.6
4.4
5.70
5.79
mmol/l
0.62
163
1600
9
54
1.70
0.75
1.8
2.0
—
—
—
0
0
11
70
1.60
0.66
4.6
4.9
24.66
25.48
mmol/l
0.46
11
70
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
176
1691
1.31
0.60
6.8
5.2
1.70
2.57
mu/l
0.66
165
1561
44
520
0.80
0.60
1.8
1.6
1.31
1.40
mmol/l
0.33
38
441
0
22
0.00
0.59
0.0
1.4
—
—
—
0
0
6
35
1.74
0.58
2.2
2.0
—
—
—
0
0
8
54
1.50
0.58
1.1
1.3
—
2.35
—
0
11
48
410
1.22
0.55
2.0
2.9
357.37
827.81
ng/l
2.35
41
352
197
1931
1.68
0.53
17.8
17.6
39.99
39.99
%
0.01
189
1811
6
40
1.51
0.52
1.2
1.1
—
—
—
0
0
43
366
1.22
0.51
2.8
2.0
2.68
3.02
mg/l
0.47
38
308
7
45
1.58
0.49
1.6
1.2
—
—
—
0
0
20
155
1.32
0.49
1.8
3.2
—
—
—
0
0
5
84
0.59
0.46
1.4
1.7
—
—
—
0
0
101
938
1.15
0.43
5.0
5.4
10.14
9.65
umol/l
0.39
96
881
184
1792
1.29
0.43
5.0
4.9
2.97
2.91
mmol/l
0.35
170
1663
14
105
1.36
0.42
1.1
1.1
—
—
—
0
0
5
33
1.53
0.41
1.2
3.2
19.60
61.57
u/ml
—
5
33
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
5
35
1.44
0.39
1.0
2.2
—
—
—
0
0
94
875
1.14
0.37
3.6
4.7
0.00
0.00
estimate
-0.00
11
167
33
379
0.85
0.34
1.2
1.3
51.89
33.13
iu/ml
—
7
142
6
89
0.66
0.33
1.5
2.0
5.55
2.26
mg/l
—
6
65
6
46
1.31
0.33
1.2
2.2
—
287.79
—
0
19
24
202
1.21
0.33
2.2
2.0
26.50
22.62
%
0.60
24
170
42
470
0.87
0.32
4.2
3.6
0.00
0.00
estimate
-0.00
11
168
121
1155
1.12
0.30
2.9
3.1
—
—
—
0
0
92
865
1.12
0.30
2.9
3.4
0.00
0.00
estimate
-0.00
12
175
13
103
1.28
0.29
2.4
2.8
98.31
133.97
ng/l
0.54
13
95
29
331
0.86
0.29
2.4
1.6
456.54
18182309.08
pmol/l
0.50
24
275
8
65
1.24
0.27
2.4
1.9
—
—
—
0
0
25
216
1.18
0.27
6.3
5.9
—
—
—
0
0
172
1680
1.16
0.27
4.1
3.9
1.19
1.26
mmol/l
0.74
158
1554
180
1765
1.18
0.26
4.6
4.4
5.00
4.95
mmol/l
0.30
168
1642
93
881
1.10
0.25
2.9
3.4
0.00
0.02
estimate
0.50
11
164
13
105
1.25
0.25
1.2
1.6
—
—
—
0
0
26
296
0.86
0.25
2.8
3.6
219.16
171.13
ng/l
0.11
19
213
18
152
1.20
0.24
1.1
1.2
122.60
161.95
iu/ml
—
5
76
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
2.86
—
0
10
0
10
0.00
0.21
0.0
3.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
1.32
—
0
5
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
2.00
—
0
6
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
9
112
0.79
0.20
1.2
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
28
252
1.13
0.19
2.1
2.4
0.70
1.06
e6/l
0.52
18
134
7
59
1.19
0.18
1.7
1.4
—
—
—
0
0
26
234
1.13
0.17
2.1
2.7
1.19
3.97
e6/l
2.71
16
116
17
148
1.16
0.17
3.8
6.9
0.92
1.73
mmol/l
0.76
12
123
7
63
1.11
0.17
2.6
1.8
—
—
—
0
0
120
1164
1.08
0.17
3.4
2.8
41.27
42.99
u/l
0.11
112
1092
8
68
1.18
0.17
1.4
1.8
—
—
—
0
0
178
1754
1.12
0.16
4.6
4.4
1.64
1.61
mmol/l
0.55
165
1628
20
178
1.14
0.16
1.4
1.7
—
—
—
0
0
11
93
1.19
0.15
1.4
1.4
—
—
—
0
0
24
218
1.11
0.14
4.5
4.4
34.31
33.07
%
0.28
16
140
58
551
1.07
0.14
2.7
2.8
—
—
—
0
0
66
689
0.94
0.13
3.1
3.4
—
—
—
0
0
9
108
0.83
0.13
1.4
1.4
—
—
—
0
0
21
230
0.90
0.12
1.5
1.9
—
—
—
0
0
26
241
1.09
0.11
2.2
2.0
15.19
13.99
umol/l
0.32
26
223
5
45
1.11
0.10
1.2
1.1
—
—
—
0
0
68
703
0.95
0.09
10.7
8.8
1.15
1.12
inr
0.12
22
224
15
165
0.90
0.09
2.4
2.3
66.29
69.86
ml/min/173m2
—
7
63
165
1631
1.06
0.09
5.7
5.2
38.00
39.05
mmol/mol
1.11
153
1519
6
58
1.04
0.08
1.3
1.7
—
—
—
0
0
5
64
0.78
0.08
1.2
1.1
—
—
—
0
0
5
64
0.78
0.08
1.2
1.1
—
—
—
0
0
7
65
1.08
0.08
1.1
1.6
—
—
—
0
0
8
77
1.04
0.07
1.8
1.4
—
—
—
0
0
14
153
0.91
0.07
1.1
1.8
—
—
—
0
0
7
81
0.86
0.07
1.4
1.3
—
—
—
0
0
15
140
1.08
0.04
2.3
2.0
0.21
0.22
g/l
0.34
15
133
37
358
1.04
0.04
1.5
1.5
—
—
—
0
0
44
452
0.97
0.04
1.5
1.2
0.72
2.27
u/ml
—
10
134
78
767
1.03
0.04
2.7
2.3
76.78
78.70
nmol/l
0.24
70
694
176
1751
1.04
0.02
11.2
11.7
17.03
19.37
mg/l
0.64
146
1337
14
148
0.94
0.02
1.6
1.6
—
—
—
0
0
61
603
1.02
0.01
2.9
3.2
11.81
27.19
ng/l
1.48
32
387
92
926
0.99
0.00
3.5
3.8
6.51
6.42
mmol/l
0.20
92
851
11
111
0.99
0.00
1.6
2.2
3.07
4.38
ug/l
0.60
11
100
15
151
0.99
0.00
1.2
1.8
—
—
—
0
0
16
159
1.01
0.00
1.6
1.7
—
—
—
0
0
28
284
0.98
0.00
2.4
1.6
1115.86
1152.01
nmol/l
0.08
21
210
42
421
1.00
0.00
2.2
2.8
0.10
0.42
e6/l
1.73
31
313
66
663
0.99
0.00
2.2
1.9
102.84
98.29
pmol/l
0.31
36
320
49
488
1.01
0.00
4.1
3.5
7.47
6.41
mg/mmol
0.08
32
278
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
7.77
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: CD2_INSITU_BREAST – Carcinoma in situ of breast
GWS hits: 1
This endpoint is excluded from FinRegistry analyses (omitted endpoint).