This is a non-core endpoint: only basic statistics are computed.
See its core counterpart CD2_INSITU_BREAST_NOS_EXALLC for full statistics.
Carcinoma in situ of breast, other/unspecified
CD2_INSITU_BREAST_NOS
breast ductal carcinoma in situ: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
471 |
4. Check minimum number of eventsNone |
471 |
5. Include endpointsNone |
471 |
6. Filter based on genotype QC (FinnGen only) |
471 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Carcinoma in situ of breast, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Carcinoma in situ of breast, other/unspecified
- Neoplasms
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 471 | 471 | - |
| Unadjusted period prevalence (%) | 0.16 | 0.16 | - |
| Median age at first event (years) | 58.47 | 58.47 | - |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 414
- Matched controls
- 4139
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D05.9
ICD-10 Finland
Carcinoma in situ of breast, unspecified
+∞
323.0
301
*
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
82.7
202.0
222
57
8500/2-C50.9
ICD-O-3
Intraductal carcinoma, noninfiltrating, NOS, of breast, NOS
92.6
141.8
153
26
PJA12
NOMESCO Finland
Sentinel node biopsy
10.8
83.2
185
288
D05.7
ICD-10 Finland
Other carcinoma in situ of breast
+∞
75.3
70
*
HAC20
NOMESCO Finland
Total mastectomy
13.8
75.3
140
148
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
11.7
75.2
154
199
HAB40
NOMESCO Finland
Wedge excision of mammary gland
10.8
70.1
150
207
2330A
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Breast
+∞
57.7
54
*
C50.99
ICD-10 Finland
Breast, unspecified
14.0
56.9
102
94
HAE10
NOMESCO Finland
Reconstruction of breast using graft or flap
22.1
50.7
75
41
HAE20
NOMESCO Finland
Reconstruction of areola and mamilla using graft or flap
27.8
46.6
64
27
HA1AA
NOMESCO Finland
X-ray mammography
6.3
44.7
137
301
TQW20
NOMESCO Finland
Tatoe
35.7
43.6
56
18
115
Kela drug reimbursment
Breast cancer
5.7
41.1
138
335
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
6.2
39.4
119
252
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
7.8
38.3
95
152
8503/2-C50.9
ICD-O-3
Noninfiltrating intraductal papillary adenocarcinoma of breast, NOS
+∞
34.9
33
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
5.5
32.0
106
245
C50
ICD-10 Finland
Malignant neoplasm of breast
8.8
28.0
62
81
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
7.1
25.9
66
107
HAC15
NOMESCO Finland
Subcutaneous mastectomy with excision of mamilla
23.1
25.2
36
17
D05.0
ICD-10 Finland
Lobular carcinoma in situ
46.1
24.9
30
7
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.3
24.6
157
643
HAB00
NOMESCO Finland
Excision of lesion of mammary gland
8.1
24.2
56
78
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
5.7
23.7
72
147
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
5.8
21.8
65
129
ZZR10
NOMESCO Finland
Flap of skin and muscle
19.1
21.2
32
18
N60.9
ICD-10 Finland
Benign mammary dysplasia, unspecified
28.7
20.3
27
10
L02BA01
ATC
tamoxifen; oral
5.6
19.5
59
119
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
6.2
19.4
54
98
Z31.5
ICD-10 Finland
Genetic counselling
6.0
19.3
55
103
HAD30
NOMESCO Finland
Reduction mammoplasty with transposition of areola
6.3
18.7
51
90
Z85.3
ICD-10 Finland
Personal history of malignant neoplasm of breast
18.7
18.5
28
16
L02BG04
ATC
letrozole; oral
4.1
18.2
76
214
HAD99
NOMESCO Finland
Other plastic operation on breast
36.7
16.8
21
6
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
9.6
16.8
34
38
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
8.4
16.7
37
48
9703
FHL
Breast resection
11.1
16.5
31
30
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
8.7
15.9
34
42
9707
FHL
Ablation of mammae and removal of axillary lymph nodes
20.2
15.7
23
12
H02AB02
ATC
dexamethasone; systemic
3.4
15.7
85
295
N63
ICD-10 Finland
Unspecified lump in breast
3.9
15.3
66
191
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.4
15.1
177
983
HAB99
NOMESCO Finland
Other partial excision of mammary gland
5.5
14.8
44
87
WX702
NOMESCO Finland
Supraglottic ventilation device
4.6
14.7
53
129
HAE99
NOMESCO Finland
Other reconstruction of breast
13.2
14.6
25
20
D05
ICD-10 Finland
Carcinoma in situ of breast
155.2
14.6
15
*
XX3DW
NOMESCO Finland
Time consuming IT work
3.4
13.9
72
241
A04AA02
ATC
granisetron; systemic, transdermal
4.0
13.8
57
158
PJD42
NOMESCO Finland
Excision of axillary lymph nodes
11.0
13.4
25
24
C50.11
ICD-10 Finland
Malignant tumor of the central part of the mammary gland,ductal tumor
7.5
13.3
31
44
HAE05
NOMESCO Finland
Reconstruction of breast using soft tissue and prosthesis
23.4
13.0
18
8
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
5.4
13.0
39
78
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
5.2
12.6
39
81
C50.4
ICD-10 Finland
Malignant neoplasm: Upper-outer quadrant of breast
8.4
12.5
27
34
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
7.1
12.5
30
45
ZX080
NOMESCO Finland
Image guided radiotherapy
6.7
12.4
31
49
Z80.3
ICD-10 Finland
Family history of malignant neoplasm of breast
8.6
12.2
26
32
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
5.7
11.6
33
62
9702
FHL
Breast exploration and possible tumor removal
7.0
10.9
26
39
ZZQ10
NOMESCO Finland
Free microvascular graft of skin and muscle
16.6
10.4
16
10
C50.51
ICD-10 Finland
Malignant tumor of the lower outer quadrant of the mammary gland, ductal tumor
6.9
10.4
25
38
HAE00
NOMESCO Finland
Reconstruction of breast using prosthesis
20.6
9.9
14
7
A03FA01
ATC
metoclopramide; systemic, rectal
2.2
9.8
123
676
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
5.1
9.7
30
63
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.1
9.5
36
93
TQB05
NOMESCO Finland
Puncture of skin of trunk
11.0
9.4
17
16
X76
ICPC
Malignant neoplasm breast female
5.0
9.0
28
59
5702
FHL
Local lymph node removal (eg armpit, groin)
12.9
8.9
15
12
HAA10
NOMESCO Finland
Biopsy of mammary gland
9.8
8.9
17
18
C50.19
ICD-10 Finland
Malignant tumor of the central part of the mammary gland, other or undeterminated histology
14.4
8.7
14
10
8500/2-C50.4
ICD-O-3
Intraductal carcinoma, noninfiltrating, NOS, of upper-outer quadrant of breast
51.1
8.7
10
*
ZZF00
NOMESCO Finland
Graft of adipose tissue
9.3
8.6
17
19
HAB50
NOMESCO Finland
Partial excision of mammary gland with reconstructive operation
4.7
8.5
28
63
PJ5YQ
NOMESCO Finland
NA
+∞
8.4
8
*
HAD40
NOMESCO Finland
Mastopexy
11.1
8.4
15
14
Z42.1
ICD-10 Finland
Follow-up care involving plastic surgery of breast
14.9
8.2
13
9
HA1AE
SPAT
NA
7.1
8.2
19
28
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
5.6
7.9
22
41
9706
FHL
Ablation mammae, includes axillary exploration
13.4
7.9
13
10
HAC10
NOMESCO Finland
Subcutaneous mastectomy with preservation of mamilla
45.8
7.7
9
*
NK6AN
NOMESCO Finland
Total body bone isotope imaging
5.1
7.7
23
47
WF003
NOMESCO Finland
Adjuvant radiotherapy
3.8
7.6
31
86
HAD20
NOMESCO Finland
Liposuction of breast
81.5
7.4
8
*
A04AD12
ATC
aprepitant; systemic
4.8
7.3
23
50
HAD50
NOMESCO Finland
Removal of prosthetic implant from breast
20.4
7.2
10
5
HA1AA
SPAT
NA
5.6
7.0
19
35
HA4ST
NOMESCO Finland
Labeling mammary gland pathology with sterotactic guidance
14.1
6.9
11
8
HAD60
NOMESCO Finland
Replacement of prosthetic implant in breast
14.1
6.9
11
8
HWD00
NOMESCO Finland
Reoperation for deep haemorrhage in surgery of mammary gland
9.5
6.8
13
14
C50.59
ICD-10 Finland
Malignant tumor of the lower outer quadrant of the mammary gland, other or undeterminated histology
17.0
6.8
10
6
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
5.1
6.8
20
41
1749X
ICD-9 Finland
Malignant neoplasm of female breast, Breast (female), unspecified
22.9
6.7
9
*
C50.39
ICD-10 Finland
Malignant tumor of the lower inner quadrant of the mammary gland, other or undeterminated histology
12.5
6.6
11
9
C50.89
ICD-10 Finland
Overall malignant tumor of the mammary gland, other or undeterminated histology
8.9
6.6
13
15
HA6BA
NOMESCO Finland
Breast tomosynthesis specimen
7.0
6.6
15
22
WX402
NOMESCO Finland
General anaesthesia
2.1
6.5
80
429
HA1AT
NOMESCO Finland
Biopsy of mammary glands with ultrasound guidance
4.0
6.5
24
62
ZXE00
NOMESCO Finland
One hour or less
1.7
6.4
174
1227
QB2S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in chest
11.3
6.3
11
10
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
4.5
6.3
21
49
HA1DG
NOMESCO Finland
Very extensive MRI examination of mammary gland with high intensity magnet
6.4
6.2
15
24
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.5
6.2
47
202
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
12.8
6.1
10
8
HA3ST
NOMESCO Finland
Removal of lesion of breast with radiological guidance
12.8
6.1
10
8
2393A
ICD-9 Finland
Neoplasm of unspecified nature, Breast
12.8
6.1
10
8
1744A
ICD-9 Finland
Malignant neoplasm of female breast, Upper-outer quadrant
6.9
6.1
14
21
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: CD2_INSITU_BREAST_NOS – Carcinoma in situ of breast, other/unspecified
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).