This is a non-core endpoint: only basic statistics are computed.
See its core counterpart CD2_INSITU_BREAST_LOBULAR_EXALLC for full statistics.
Carcinoma in situ of breast, lobular
CD2_INSITU_BREAST_LOBULAR
breast ductal carcinoma in situ: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
244 |
4. Check minimum number of eventsNone |
244 |
5. Include endpointsNone |
244 |
6. Filter based on genotype QC (FinnGen only) |
244 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D05
- Name in latin
- Carcinoma in situ lobulare mammae
Similar endpoints
↥List of similar endpoints to
Carcinoma in situ of breast, lobular
based on the number of shared cases.
Similar with more cases:
- Carcinoma in situ of breast, lobular
- In situ neoplasms
- In situ neoplasms
- Neoplasms
- Any operation in hilmo
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 244 | 244 | - |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | - |
| Median age at first event (years) | 58.32 | 58.32 | - |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 214
- Matched controls
- 2140
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D05.0
ICD-10 Finland
Lobular carcinoma in situ
+∞
306.6
213
*
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
62.3
102.4
119
42
PJA12
NOMESCO Finland
Sentinel node biopsy
13.4
55.3
112
162
8500/2-C50.9
ICD-O-3
Intraductal carcinoma, noninfiltrating, NOS, of breast, NOS
33.3
43.5
57
23
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
12.0
41.7
84
109
HA1AA
NOMESCO Finland
X-ray mammography
10.2
40.8
92
147
HAC20
NOMESCO Finland
Total mastectomy
14.4
39.6
71
71
115
Kela drug reimbursment
Breast cancer
8.5
35.9
91
171
HAB40
NOMESCO Finland
Wedge excision of mammary gland
10.7
35.9
76
105
8520/2-C50.9
ICD-O-3
Lobular carcinoma in situ, NOS, of breast, NOS
377.5
32.8
32
*
HAB99
NOMESCO Finland
Other partial excision of mammary gland
15.3
31.7
54
46
HAE20
NOMESCO Finland
Reconstruction of areola and mamilla using graft or flap
34.8
31.2
40
14
HAE10
NOMESCO Finland
Reconstruction of breast using graft or flap
25.6
28.7
40
19
TQW20
NOMESCO Finland
Tatoe
40.1
27.5
34
10
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
7.6
25.1
64
113
D05.9
ICD-10 Finland
Carcinoma in situ of breast, unspecified
64.0
24.7
28
5
HAC15
NOMESCO Finland
Subcutaneous mastectomy with excision of mamilla
41.6
23.7
29
8
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
9.4
22.2
48
64
N63
ICD-10 Finland
Unspecified lump in breast
7.4
21.8
56
98
C50.99
ICD-10 Finland
Breast, unspecified
9.7
21.4
45
57
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
16.9
20.2
32
22
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
14.2
19.9
34
28
L02BA01
ATC
tamoxifen; oral
7.3
17.9
45
75
HAE99
NOMESCO Finland
Other reconstruction of breast
46.3
17.6
21
5
HAB00
NOMESCO Finland
Excision of lesion of mammary gland
9.0
17.6
38
50
L02BG04
ATC
letrozole; oral
6.0
17.3
51
106
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
10.6
16.9
33
36
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
7.4
16.7
41
66
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
5.9
16.5
49
102
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
6.2
16.1
46
91
HA1AT
NOMESCO Finland
Biopsy of mammary glands with ultrasound guidance
12.2
16.1
29
27
C50.42
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor
11.4
16.1
30
30
ZZR10
NOMESCO Finland
Flap of skin and muscle
27.4
15.0
20
8
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
7.7
14.5
34
51
D48.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Breast
10.0
13.2
26
29
HAD30
NOMESCO Finland
Reduction mammoplasty with transposition of areola
7.0
12.9
32
52
HAE05
NOMESCO Finland
Reconstruction of breast using soft tissue and prosthesis
28.6
12.2
16
6
ZZF00
NOMESCO Finland
Graft of adipose tissue
22.9
12.2
17
8
C50
ICD-10 Finland
Malignant neoplasm of breast
8.0
12.0
27
38
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
10.2
11.8
23
25
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
5.8
11.5
33
65
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.8
11.1
100
514
HA1CG
NOMESCO Finland
Extensive MRI examination of mammary gland with high intensity magnet
10.5
11.0
21
22
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
10.9
109
592
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
7.2
10.9
26
40
XX3DW
NOMESCO Finland
Time consuming IT work
3.9
10.9
48
148
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
10.0
10.8
21
23
D24
ICD-10 Finland
Benign neoplasm of breast
10.0
10.8
21
23
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
10.5
86
411
HAE00
NOMESCO Finland
Reconstruction of breast using prosthesis
34.4
10.5
13
*
A04AA02
ATC
granisetron; systemic, transdermal
4.8
10.3
35
84
H02AB02
ATC
dexamethasone; systemic
3.6
10.1
49
164
C50.92
ICD-10 Finland
Malignant tumor in another specified localization in lobular gland, lobular tumor
27.5
9.9
13
5
HA1TE
NOMESCO Finland
Supplementary or limited ultrasound examination of mammary glands
13.2
9.5
16
13
TQB05
NOMESCO Finland
Puncture of skin of trunk
16.5
9.2
14
9
Z42.1
ICD-10 Finland
Follow-up care involving plastic surgery of breast
17.2
8.7
13
8
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.7
8.6
74
355
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
6.0
8.6
23
42
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
6.5
8.4
21
35
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
8.7
8.3
17
21
X76
ICPC
Malignant neoplasm breast female
6.3
8.2
21
36
HA4MT
NOMESCO Finland
Labeling mammary gland pathology with X-ray guidance
26.1
7.6
10
*
Z31.5
ICD-10 Finland
Genetic counselling
4.5
7.5
26
64
C50.82
ICD-10 Finland
Overall malignant tumor of the mammary gland, lobular tumor
14.0
7.5
12
9
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
5.9
7.4
20
37
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
4.1
7.4
28
75
ZXA05
NOMESCO Finland
Left side
2.4
7.2
71
365
ZXE30
NOMESCO Finland
More than five and less than seven hours
5.3
7.2
21
43
L02BG03
ATC
anastrozole; oral
6.8
6.8
16
25
Z80.3
ICD-10 Finland
Family history of malignant neoplasm of breast
8.2
6.7
14
18
HAD99
NOMESCO Finland
Other plastic operation on breast
12.8
6.7
11
9
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
6.6
110
714
NK6AN
NOMESCO Finland
Total body bone isotope imaging
8.6
6.4
13
16
HA013
NOMESCO Finland
Radiotherapy after total ablation of mammary gland
8.6
6.4
13
16
HAD50
NOMESCO Finland
Removal of prosthetic implant from breast
18.7
6.3
9
5
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: CD2_INSITU_BREAST_LOBULAR – Carcinoma in situ of breast, lobular
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).