Acquired pure red cell aplasia [erythroblastopenia]

D3_ACQPUREREDCLLAPLASIA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D60
  • Hospital discharge: ICD-9 2848C
  • Hospital discharge: ICD-8 28404
  • Cause of death: ICD-10 D60
  • Cause of death: ICD-9 2848C
  • Cause of death: ICD-8 28404

2 out of 7 registries used, show all original rules.

158

4. Check minimum number of events

None

158

5. Include endpoints

None

158

6. Filter based on genotype QC (FinnGen only)

158

Control definitions (FinnGen only)

Control exclude
D3_APLASTICANDOTHANAEMIA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D60-D64
Name in latin
Erythroblastopenia [pura] acquisita

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1585 812 763
Only index persons 1228 642 586
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 50.27 49.87 50.40
Only index persons 51.23 50.58 51.94

-FinnGen-

Key figures

All Female Male
Number of individuals 158 78 80
Unadjusted period prevalence (%) 0.03 0.03 0.04
Median age at first event (years) 61.35 56.48 66.11

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
146
Matched controls
1458
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D60.9
ICD-10 Finland
Acquired pure red cell aplasia, unspecified
+∞
97.0
82
*
D64.9
ICD-10 Finland
Anaemia, unspecified
53.1
54.1
64
21
D60.0
ICD-10 Finland
Chronic acquired pure red cell aplasia
+∞
28.0
26
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.8
21.2
79
245
D60.1
ICD-10 Finland
Transient acquired pure red cell aplasia
+∞
20.3
19
*
122
Kela drug reimbursment
Aplastic anaemia
+∞
17.0
16
*
XW000
NOMESCO Finland
Bone marrow biopsy
14.1
15.3
26
22
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
10.9
14.5
28
31
D60.8
ICD-10 Finland
Other acquired pure red cell aplasias
+∞
13.8
13
*
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
+∞
12.7
12
*
WW500
NOMESCO Finland
Blood transfusion
13.4
12.3
21
18
UJF32
NOMESCO Finland
Coloscopy
3.8
11.4
58
214
UJF92
NOMESCO Finland
Capsular endoscopy
32.4
9.6
12
*
28404
ICD-8 Finland
Aplastic anaemia, Erythroblastopenia acquisita
+∞
8.4
8
*
L04AD01
ATC
ciclosporin; systemic
12.8
8.3
14
12
J01MA12
ATC
levofloxacin; systemic
3.3
7.6
42
159
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
7.5
63
315
D64.8
ICD-10 Finland
Other specified anaemias
31.7
7.2
9
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.1
6.9
27
77
A28
ICPC
Limited function/disability NOS
3.4
6.6
35
125
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
6.5
78
460
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
6.4
34
123
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
28.0
6.3
8
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
+∞
6.3
6
*
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
+∞
6.3
6
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
8.3
6.3
13
17
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
5.7
6.2
17
33
B82
ICPC
Anaemia other/unspecified
13.3
6.2
10
8
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.9
6.1
19
43
R50.9
ICD-10 Finland
Fever, unspecified
3.4
6.0
29
99

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
53
43
18.04
56.81
2.8
2.0
1.3
1.6
g/l
0.86
44
38
22
11
23.07
28.93
1.3
1.3
—
—
—
0
0
59
144
5.94
24.62
4.0
2.4
30.1
22.5
%
1.24
52
122
82
279
5.03
22.87
3.3
2.0
3.2
2.9
mg/l
0.41
73
231
48
104
6.19
22.59
13.8
2.9
63.8
63.7
e9/l
0.01
41
81
17
10
18.93
20.58
1.2
1.0
—
—
—
0
0
99
478
3.87
15.47
5.3
2.5
325.8
104.9
ug/l
2.29
94
427
86
386
3.69
14.87
13.2
5.4
—
—
—
0
0
17
18
10.46
14.59
1.9
1.4
—
—
—
0
0
18
24
8.34
12.98
1.7
3.0
—
—
—
0
0
100
532
3.40
12.52
14.4
5.6
0.7
0.6
%
0.92
95
487
101
548
3.34
12.09
14.4
5.5
2.7
2.7
%
0.15
96
503
101
550
3.32
11.98
14.7
6.0
9.2
8.6
%
0.98
96
506
28
65
5.02
11.78
1.9
1.7
1.0
1.2
g/l
0.30
22
59
107
607
3.36
11.76
13.0
5.7
0.2
0.2
e9/l
0.04
97
532
104
582
3.30
11.66
12.5
5.5
0.6
0.6
e9/l
0.18
93
502
104
583
3.29
11.61
12.5
5.5
0.0
0.0
e9/l
0.14
93
506
45
152
3.74
11.59
11.0
6.3
1.1
1.1
mmol/l
0.12
40
137
102
568
3.25
11.46
14.7
5.8
29.5
27.7
%
0.60
96
520
46
161
3.62
11.20
1.4
1.2
—
—
—
0
0
12
11
11.72
11.19
1.2
1.2
—
—
—
0
0
19
32
6.61
11.14
1.3
1.7
—
—
—
0
0
30
78
4.51
10.99
2.3
2.4
—
—
—
0
0
15
20
8.18
10.75
1.3
1.8
236.6
363.7
u/ml
—
7
11
47
171
3.49
10.75
5.4
4.6
0.8
0.8
mmol/l
1.57
42
155
55
223
3.25
10.54
2.3
1.7
1101.8
1186.1
nmol/l
0.27
38
165
103
596
3.09
10.47
13.2
5.7
1.7
1.9
e9/l
0.58
94
536
71
336
3.02
10.39
7.9
3.7
—
—
—
0
0
20
39
5.73
10.13
2.1
2.6
39.4
77.0
mg/l
0.55
15
31
20
39
5.73
10.13
2.1
2.6
36.4
35.2
mg/l
0.03
15
31
97
557
2.92
9.75
13.6
5.6
55.9
57.5
%
0.56
92
514
13
17
8.24
9.42
1.4
1.5
—
—
—
0
0
73
370
2.81
9.17
6.1
2.4
—
—
—
0
0
12
5
25.77
9.05
1.4
1.4
—
—
—
0
0
30
90
3.88
9.02
12.1
7.7
—
—
—
0
0
46
183
3.14
8.94
1.7
1.6
—
—
—
0
0
35
119
3.49
8.76
8.7
6.0
-0.2
1.1
mmol/l
0.76
27
100
10
10
10.61
8.73
1.1
1.3
—
—
—
0
0
10
10
10.61
8.73
2.2
2.7
—
—
—
0
0
38
137
3.34
8.67
1.8
1.4
—
—
—
0
0
83
461
2.69
8.56
3.5
1.9
92.8
96.3
pmol/l
0.36
52
226
108
694
2.76
8.15
18.9
8.3
3.9
4.1
e9/l
0.32
98
598
85
487
2.61
8.10
9.4
4.5
33.7
35.7
g/l
2.47
77
449
61
302
2.66
7.78
5.3
2.9
360.3
8620.6
umol/l
1.76
52
248
25
73
3.88
7.77
7.2
7.9
23.8
24.2
mmol/l
0.19
25
73
10
12
8.83
7.66
2.4
2.0
0.6
1.0
e9/l
—
5
5
69
370
2.54
7.40
9.3
3.6
7.4
7.4
ph
0.56
15
73
35
132
3.12
7.35
1.9
1.6
—
—
—
0
0
10
5
21.20
7.23
1.4
1.4
—
—
—
0
0
26
82
3.60
7.23
1.3
1.4
—
—
—
0
0
57
284
2.58
7.07
2.2
1.5
22.7
20.0
nmol/l
0.60
51
227
20
53
4.18
7.06
11.7
8.9
—
—
—
0
0
60
309
2.52
6.93
10.2
6.6
—
—
—
0
0
30
107
3.23
6.88
5.6
4.9
—
—
—
0
0
47
218
2.65
6.70
2.0
1.8
—
—
—
0
0
35
143
2.86
6.33
5.6
2.9
8.6
7.2
umol/l
0.19
30
124
98
650
2.34
6.18
13.2
5.3
13.2
11.3
umol/l
0.58
93
612
12
23
5.56
6.11
4.7
2.5
3.7
3.9
e9/l
0.14
12
23
12
23
5.56
6.11
5.7
2.6
55.6
58.5
%
0.21
12
23
12
23
5.56
6.11
1.4
1.4
—
—
—
0
0
28
103
3.09
6.08
5.9
4.8
1.8
1.8
mmol/l
0.00
22
72
26
93
3.15
5.91
12.5
3.7
0.1
0.2
%
0.50
16
26
38
170
2.63
5.75
2.7
1.9
—
—
—
0
0
25
89
3.15
5.72
11.6
3.8
0.0
0.4
%
0.56
14
22
10
17
6.21
5.70
14.7
2.2
33.9
32.0
pg
—
10
17
27
102
2.99
5.59
12.4
3.6
0.5
0.9
%
0.80
16
32
24
88
3.04
5.22
12.9
3.6
0.2
0.5
%
0.58
13
18
33
147
2.57
5.00
1.5
1.3
—
—
—
0
0
44
227
2.30
4.84
5.4
3.4
76.3
207.7
ng/l
1.04
37
176
8
7
11.95
4.84
2.8
1.4
0.1
0.1
e9/l
—
8
7
82
545
2.05
4.68
23.5
9.0
0.0
0.0
e9/l
0.00
66
442
58
344
2.08
4.47
4.3
3.1
—
—
—
0
0
62
377
2.06
4.47
3.7
2.8
—
—
—
0
0
47
257
2.18
4.47
1.9
1.3
2.0
2.3
g/l
0.52
30
147
75
492
2.00
4.36
10.6
9.4
1.2
1.3
inr
0.74
26
151
45
245
2.17
4.31
3.0
2.9
508.6
544.6
mosm/kgh2o
0.57
35
207
8
10
8.35
4.11
1.7
1.8
—
—
—
0
0
47
270
2.05
3.88
3.3
2.5
2.6
5.0
e6/l
2.42
40
238
22
91
2.65
3.84
2.7
3.3
272.5
176.3
ng/l
0.33
22
79
45
257
2.05
3.76
2.7
1.7
0.8
1.4
mg/l
1.48
34
189
10
25
4.20
3.76
6.6
2.3
9.4
8.6
kpa
—
10
25
10
25
4.20
3.76
6.6
2.3
4.8
5.1
kpa
—
10
25
8
12
6.95
3.72
1.1
1.0
—
—
—
0
0
111
865
1.95
3.60
4.5
3.7
15.0
14.9
pmol/l
0.12
105
757
29
142
2.28
3.55
11.4
6.5
104.6
104.2
mmol/l
0.12
29
137
8
13
6.42
3.54
1.0
1.0
—
—
—
0
0
56
355
1.89
3.43
4.1
3.2
6.8
7.6
mmol/l
0.74
49
291
28
137
2.27
3.43
1.4
1.4
173.3
685.9
titre
—
6
34
53
334
1.88
3.29
4.3
3.2
89.9
258.2
mg/l
0.40
35
210
6
7
8.85
3.29
3.0
2.7
—
—
—
0
0
7
11
6.60
3.22
1.4
4.1
—
—
—
0
0
59
392
1.81
3.06
4.7
3.3
18.9
58.6
e6/l
1.85
49
306
66
454
1.78
3.05
5.4
3.9
89.3
69.8
e6/l
0.15
53
324
10
30
3.49
2.96
7.1
2.2
7.4
7.4
ph
—
10
25
6
9
6.87
2.89
1.2
1.0
—
—
—
0
0
6
9
6.87
2.89
2.2
1.9
9.8
3.6
mg/l
—
6
9
107
855
1.78
2.86
6.3
4.2
—
—
—
0
0
68
479
1.74
2.85
2.5
2.2
—
—
—
0
0
65
457
1.72
2.72
6.5
3.8
73.5
34.9
ng/l
0.80
51
331
8
19
4.38
2.71
1.9
2.5
—
—
—
0
0
10
32
3.27
2.69
1.2
1.3
—
—
—
0
0
53
355
1.74
2.62
4.6
3.2
0.1
0.3
e6/l
2.27
44
267
6
11
5.62
2.56
1.3
1.5
—
—
—
0
0
22
110
2.16
2.56
1.8
1.7
—
—
—
0
0
22
113
2.10
2.40
1.8
1.4
—
—
—
0
0
43
278
1.75
2.38
1.4
1.2
2.8
1.1
u/ml
0.37
12
68
30
175
1.88
2.31
1.3
1.3
29.2
24.7
iu/ml
—
10
56
51
350
1.68
2.27
5.7
4.1
15.7
60.9
mg/mmol
0.41
37
215
15
67
2.37
2.25
4.9
6.8
—
—
—
0
0
10
36
2.90
2.24
3.7
3.4
—
—
—
0
0
98
794
1.62
2.21
5.2
3.9
—
—
—
0
0
125
1080
1.75
2.17
5.6
4.5
2.1
2.0
mu/l
0.31
118
960
11
43
2.67
2.14
1.5
1.2
—
—
—
0
0
14
63
2.34
2.08
4.7
6.9
25.0
24.5
mmol/l
0.19
14
63
11
44
2.61
2.06
1.5
1.2
—
—
—
0
0
11
44
2.61
2.06
1.5
1.2
—
—
—
0
0
11
44
2.61
2.06
1.5
1.2
—
—
—
0
0
15
70
2.26
2.06
4.9
3.5
—
—
—
0
0
46
317
1.64
1.99
1.6
1.5
—
—
—
0
0
135
1203
1.84
1.97
37.1
13.5
23.1
23.7
mg/l
0.08
122
945
56
406
1.59
1.97
4.6
3.1
2.4
2.4
mmol/l
0.12
48
344
13
58
2.35
1.97
2.5
2.3
—
—
—
0
0
123
1071
1.67
1.92
33.7
14.5
36.8
39.8
%
4.05
89
746
37
244
1.67
1.88
13.1
5.1
—
—
—
0
0
10
40
2.60
1.87
1.5
1.3
—
—
—
0
0
6
17
3.62
1.85
12.7
2.2
—
—
—
0
0
6
17
3.62
1.85
9.0
3.5
—
—
—
0
0
28
172
1.76
1.83
1.3
1.3
50.0
14.1
u/ml
—
6
75
6
18
3.42
1.76
1.0
1.7
—
—
—
0
0
5
13
3.93
1.73
3.0
1.8
60.9
57.7
%
—
5
13
5
13
3.93
1.73
2.0
1.7
—
—
—
0
0
5
14
3.65
1.63
1.4
2.1
—
—
—
0
0
7
26
2.77
1.60
5.3
3.7
—
—
—
0
0
137
1246
1.75
1.59
31.8
12.4
—
—
—
0
0
7
27
2.66
1.53
1.4
1.2
—
—
—
0
0
9
38
2.45
1.48
1.9
1.1
0.3
0.2
g/l
—
9
38
5
16
3.19
1.45
3.0
3.3
6.7
3.1
nmol/l
—
5
16
5
16
3.19
1.45
2.8
2.0
—
—
—
0
0
5
16
3.19
1.45
2.8
2.0
—
—
—
0
0
5
16
3.19
1.45
2.8
2.0
—
—
—
0
0
5
16
3.19
1.45
2.8
2.0
—
—
—
0
0
9
40
2.32
1.42
1.9
1.2
1.3
1.1
g/l
—
9
40
19
113
1.77
1.39
2.2
2.2
11.4
5.0
ug/l
0.57
14
92
5
17
3.00
1.37
1.0
1.2
—
—
—
0
0
6
24
2.56
1.31
3.8
5.7
—
—
—
0
0
9
44
2.11
1.29
1.1
1.3
—
—
—
0
0
12
64
1.95
1.21
1.2
1.2
—
—
—
0
0
31
218
1.53
1.21
4.7
2.9
2.5
2.4
mmol/l
1.53
23
188
0
33
0.00
1.17
0.0
1.6
—
—
—
0
0
0
35
0.00
1.16
0.0
4.7
—
—
—
0
0
18
112
1.69
1.15
4.8
3.3
—
—
—
0
0
7
30
2.39
1.14
1.6
1.4
—
—
—
0
0
8
40
2.05
1.14
1.8
2.1
—
—
—
0
0
16
99
1.69
1.04
14.9
2.8
1.2
1.2
mmol/l
0.45
16
86
72
606
1.35
1.04
6.5
5.0
0.0
0.0
estimate
0.00
21
120
0
31
0.00
0.97
0.0
1.5
—
—
—
0
0
0
31
0.00
0.97
0.0
1.5
—
—
—
0
0
58
477
1.34
0.96
3.7
3.4
—
—
—
0
0
8
42
1.95
0.90
1.9
1.6
—
—
—
0
0
72
617
1.31
0.88
4.6
3.7
0.0
0.0
estimate
0.00
21
112
14
88
1.65
0.87
1.1
1.1
—
—
—
0
0
71
611
1.29
0.83
4.6
3.7
0.0
0.0
estimate
0.00
21
119
18
124
1.51
0.79
1.4
1.2
—
—
—
0
0
44
357
1.32
0.79
5.1
3.9
—
—
—
0
0
14
91
1.59
0.78
1.6
1.7
—
—
—
0
0
6
34
1.79
0.77
1.7
1.4
—
—
—
0
0
5
24
2.12
0.75
1.0
1.3
—
—
—
0
0
42
341
1.32
0.75
4.5
3.8
0.0
0.0
estimate
0.00
19
118
7
38
1.88
0.74
7.7
3.7
—
—
—
0
0
35
281
1.32
0.67
3.6
3.6
—
—
—
0
0
20
149
1.39
0.61
2.9
1.4
—
—
—
0
0
123
1158
1.28
0.60
5.4
4.8
2.5
2.7
mmol/l
1.18
114
1049
16
118
1.40
0.52
8.4
4.3
—
—
—
0
0
41
348
1.24
0.52
4.8
3.2
—
—
—
0
0
114
1078
1.21
0.45
4.4
3.9
1.4
1.2
mmol/l
1.57
104
979
27
222
1.26
0.45
3.2
2.9
1.2
0.8
ug/l
0.31
18
153
0
18
0.00
0.40
0.0
2.3
—
4.1
—
0
18
0
18
0.00
0.40
0.0
2.3
—
106.2
—
0
18
0
18
0.00
0.40
0.0
2.3
—
—
—
0
0
0
18
0.00
0.40
0.0
2.5
—
—
—
0
0
14
107
1.34
0.38
1.4
1.5
—
—
—
0
0
9
71
1.28
0.37
1.1
1.3
—
—
—
0
0
117
1120
1.17
0.34
4.7
4.3
1.4
1.5
mmol/l
1.67
109
1015
118
1131
1.17
0.33
4.8
4.3
4.3
4.5
mmol/l
1.32
109
1032
7
54
1.31
0.31
5.4
4.0
25.8
24.9
mmol/l
—
7
54
117
1126
1.15
0.29
5.9
4.6
6.0
5.9
mmol/l
0.08
108
1012
7
93
0.74
0.23
1.4
1.3
—
—
—
0
0
5
42
1.20
0.21
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
6
51
1.18
0.19
4.0
2.4
1.7
1.1
%
—
6
51
12
101
1.20
0.17
2.8
3.4
—
—
—
0
0
7
86
0.81
0.15
1.0
1.3
—
—
—
0
0
10
112
0.89
0.07
2.3
1.8
—
—
—
0
0
10
89
1.13
0.07
4.7
2.6
—
—
—
0
0
40
389
1.04
0.03
5.6
5.2
2.2
2.6
ug/l
0.29
30
342
36
367
0.98
0.01
2.5
2.9
—
—
—
0
0
8
80
1.00
0.00
2.3
2.4
—
21.9
—
0
5
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
9.2
—
1335.2
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
74
0.94
0.00
1.1
1.2
—
39.1
—
0
6
0
5
0.00
0.00
0.0
6.4
—
875.0
—
0
5
0
5
0.00
0.00
0.0
3.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
60
1.00
0.00
1.8
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint D3_ACQPUREREDCLLAPLASIA and mortality.

Females

Parameter HR [95% CI] p-value
D3_ACQPUREREDCLLAPLASIA 2.385 [1.8, 3.16] < 0.001
Birth year 0.998 [0.99, 1.01] 0.612

During the follow-up period (1.1.1998 — 31.12.2019), 214 out of 643 females with D3_ACQPUREREDCLLAPLASIA died.

Males

Parameter HR [95% CI] p-value
D3_ACQPUREREDCLLAPLASIA 3.507 [2.19, 5.62] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 220 out of 570 males with D3_ACQPUREREDCLLAPLASIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_ACQPUREREDCLLAPLASIA.

N-year risk Females Males
1 0.271% 0.578%
5 1.616% 3.729%
10 4.04% 9.649%
15 7.368% 16.673%
20 12.727% 26.796%

Relationships between endpoints

Index endpoint: D3_ACQPUREREDCLLAPLASIA – Acquired pure red cell aplasia [erythroblastopenia]

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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