No definition available.
Acquired pure red cell aplasia [erythroblastopenia]
D3_ACQPUREREDCLLAPLASIA
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
159 |
4. Check minimum number of eventsNone |
159 |
5. Include endpointsNone |
159 |
6. Filter based on genotype QC (FinnGen only) |
155 |
Control definitions (FinnGen only)
- Control exclude
- D3_APLASTICANDOTHANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D60-D64
- Name in latin
- Erythroblastopenia [pura] acquisita
Similar endpoints
↥List of similar endpoints to
Acquired pure red cell aplasia [erythroblastopenia]
based on the number of shared cases.
Similar with more cases:
- Aplastic and other anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1585 | 812 | 763 |
| Only index persons | 1228 | 642 | 586 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.27 | 49.87 | 50.40 |
| Only index persons | 51.23 | 50.58 | 51.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 155 | 76 | 79 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 61.47 | 56.19 | 66.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 159
- Matched controls
- 1590
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D64.9
ICD-10 Finland
Anaemia, unspecified
50.0
109.0
69
24
D60.9
ICD-10 Finland
Acquired pure red cell aplasia, unspecified
+∞
101.1
86
*
XW000
NOMESCO Finland
Bone marrow biopsy
15.2
32.5
31
25
D60.0
ICD-10 Finland
Chronic acquired pure red cell aplasia
+∞
32.4
30
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.7
27.1
84
260
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
9.6
23.9
31
39
D60.1
ICD-10 Finland
Transient acquired pure red cell aplasia
+∞
22.4
21
*
122
Kela drug reimbursment
Aplastic anaemia
+∞
20.2
19
*
D60.8
ICD-10 Finland
Other acquired pure red cell aplasias
+∞
15.9
15
*
L04AD01
ATC
ciclosporin; systemic
26.7
14.2
19
8
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
+∞
13.7
13
*
UJF32
NOMESCO Finland
Coloscopy
3.5
12.4
60
235
WW500
NOMESCO Finland
Blood transfusion
9.2
11.6
24
30
UJF92
NOMESCO Finland
Capsular endoscopy
64.4
10.8
12
*
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
6.0
10.7
20
37
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
13.4
10.6
18
15
J01MA12
ATC
levofloxacin; systemic
3.3
10.2
49
188
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
5.1
10.1
23
51
28404
ICD-8 Finland
Aplastic anaemia, Erythroblastopenia acquisita
+∞
9.5
9
*
Z2446
NOMESCO Finland
Social worker
4.7
9.3
23
55
B03BA03
ATC
hydroxocobalamin; parenteral
5.3
8.8
19
40
B82
ICPC
Anaemia other/unspecified
13.8
8.6
14
11
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.5
8.5
33
110
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.5
7.7
30
100
ZX120
NOMESCO Finland
Intravenous
3.7
7.7
27
84
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
83.8
7.5
8
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
7.2
38
152
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
7.2
86
515
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
7.2
68
366
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.5
7.0
18
44
Z2221
NOMESCO Finland
Medical doctor
2.6
7.0
55
270
D64.8
ICD-10 Finland
Other specified anaemias
14.6
7.0
11
8
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.8
6.8
22
64
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
17.6
6.8
10
6
ZXD05
NOMESCO Finland
Urgent procedure
2.5
6.8
60
311
Z3231
NOMESCO Finland
Registered nurse
2.5
6.7
58
297
L04AX01
ATC
azathioprine; systemic
9.3
6.7
13
15
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
6.6
45
205
TK800
NOMESCO Finland
Hemodialysis
11.7
6.4
11
10
D69.0
ICD-10 Finland
Allergic purpura
27.9
6.3
8
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
55
42
19.49
61.17
2.7
2.1
1.28
1.52
g/l
0.79
46
37
34
28
15.17
35.31
1.7
1.9
—
—
—
0
0
61
143
6.30
26.80
4.0
2.5
31.14
22.13
%
1.57
53
121
83
281
5.09
23.36
3.2
2.0
3.14
2.88
mg/l
0.32
74
232
100
477
3.95
16.06
5.6
2.5
338.13
106.96
ug/l
2.47
95
425
46
156
3.74
11.78
10.9
6.3
1.07
1.08
mmol/l
0.10
41
140
21
38
6.22
11.51
3.0
2.6
45.29
79.04
mg/l
0.45
16
30
21
38
6.22
11.51
3.0
2.6
35.17
35.89
mg/l
0.02
16
30
55
226
3.19
10.26
2.3
1.7
1136.79
1184.75
nmol/l
0.14
38
168
47
176
3.37
10.21
5.4
4.5
0.77
0.82
mmol/l
1.61
42
160
95
549
2.81
9.25
8.5
2.5
—
—
—
0
0
36
121
3.55
9.18
8.5
6.0
-0.11
1.15
mmol/l
0.82
29
103
99
592
2.78
8.90
13.3
6.7
1.20
1.22
mmol/l
1.03
86
505
110
695
2.89
8.87
19.8
8.2
3.90
4.10
e9/l
0.45
100
598
48
197
3.06
8.83
2.5
1.7
—
—
—
0
0
84
464
2.72
8.81
3.5
1.9
91.95
96.37
pmol/l
0.47
53
228
17
20
9.37
8.56
1.2
1.8
—
—
—
0
0
86
487
2.67
8.49
10.2
4.5
33.61
35.66
g/l
2.66
78
449
62
299
2.76
8.42
5.8
2.9
352.57
8756.41
umol/l
1.77
54
244
16
18
9.74
8.26
1.3
1.5
—
—
—
0
0
25
71
3.99
8.08
7.2
7.8
23.82
24.09
mmol/l
0.13
25
71
16
20
8.76
7.81
1.3
1.8
236.57
363.73
u/ml
—
7
11
58
285
2.63
7.45
2.2
1.5
22.69
19.98
nmol/l
0.62
52
226
37
144
3.05
7.36
6.0
2.9
8.52
7.17
umol/l
0.19
32
125
18
46
4.28
6.64
2.6
2.0
—
—
—
0
0
29
105
3.15
6.48
5.7
5.0
1.80
1.80
mmol/l
0.00
24
76
99
652
2.37
6.42
13.9
5.3
13.26
11.35
umol/l
0.61
94
614
6
0
+∞
6.29
1.8
0.0
—
—
—
0
0
21
63
3.69
6.25
1.7
1.7
—
—
—
0
0
12
14
9.17
6.17
4.4
4.6
—
—
u/ml
—
0
0
55
286
2.41
6.09
4.9
2.3
—
—
—
0
0
33
136
2.80
5.85
2.3
1.7
—
—
—
0
0
32
134
2.74
5.49
2.4
1.8
—
—
—
0
0
15
40
4.04
5.22
3.3
2.2
—
—
—
0
0
12
21
6.09
4.86
4.7
2.4
3.68
3.97
e9/l
0.16
12
21
12
21
6.09
4.86
5.7
2.4
55.58
58.57
%
0.22
12
21
8
7
11.94
4.84
1.0
2.7
—
—
—
0
0
8
7
11.94
4.84
1.0
2.7
—
—
—
0
0
44
231
2.25
4.63
5.3
3.4
49.40
207.76
ng/l
1.55
37
180
22
83
2.92
4.55
1.9
1.4
—
—
—
0
0
7
6
12.12
4.31
1.1
1.0
—
—
—
0
0
10
17
6.20
4.20
14.7
2.2
33.90
32.00
pg
—
10
17
60
370
2.00
4.09
4.7
2.8
37.36
32.81
u/l
0.39
53
348
70
458
1.94
4.01
4.6
3.3
—
—
—
0
0
82
570
1.91
3.88
17.0
14.2
1.15
1.33
inr
1.21
27
169
22
91
2.65
3.84
2.8
3.3
271.09
176.27
ng/l
0.33
22
79
45
256
2.06
3.80
2.7
1.7
0.79
1.40
mg/l
1.61
34
191
112
869
1.98
3.74
4.5
3.8
15.10
14.93
pmol/l
0.29
106
757
8
12
6.95
3.72
1.5
1.7
—
—
—
0
0
7
9
8.07
3.59
2.3
1.9
8.89
3.60
mg/l
—
7
9
21
89
2.57
3.49
4.5
7.4
2.95
1.45
mmol/l
0.84
15
67
29
144
2.24
3.43
11.4
6.5
104.55
104.36
mmol/l
0.07
29
144
13
43
3.20
3.33
2.4
1.5
—
—
—
0
0
6
7
8.85
3.29
1.8
2.6
—
—
—
0
0
19
79
2.60
3.28
1.8
1.4
—
—
—
0
0
7
11
6.60
3.22
2.3
2.5
494.29
445.64
e6/l
—
7
11
10
25
4.20
3.14
1.5
1.6
—
—
—
0
0
10
25
4.20
3.14
1.5
1.6
—
—
—
0
0
13
46
2.99
3.00
2.6
1.7
—
—
—
0
0
66
458
1.75
2.93
5.9
3.8
74.79
36.07
ng/l
0.78
50
332
9
22
4.27
2.93
2.2
2.0
—
—
—
0
0
9
22
4.27
2.93
2.2
2.0
—
—
—
0
0
6
9
6.87
2.89
1.3
1.2
—
—
—
0
0
57
381
1.77
2.87
4.5
3.2
2199.22
1313.72
ng/l
1.08
50
318
10
28
3.74
2.84
2.0
1.5
—
—
—
0
0
54
357
1.78
2.81
4.5
3.2
0.06
0.33
e6/l
2.25
44
271
35
203
1.93
2.74
3.8
3.3
0.75
2.00
e6/l
0.96
20
115
8
19
4.37
2.71
2.5
1.5
—
—
—
0
0
7
15
4.83
2.62
2.7
1.5
—
—
—
0
0
9
25
3.75
2.62
2.3
1.6
—
—
—
0
0
10
31
3.37
2.57
3.1
1.7
—
—
—
0
0
10
31
3.37
2.57
3.1
1.7
—
—
—
0
0
8
21
3.95
2.50
2.4
1.7
—
—
—
0
0
43
276
1.76
2.44
1.4
1.2
2.65
1.06
u/ml
0.36
13
69
5
8
6.41
2.39
1.0
1.3
—
—
—
0
0
30
174
1.89
2.34
1.3
1.3
29.20
24.23
iu/ml
—
10
57
95
759
1.63
2.30
5.2
2.8
85.26
49.14
u/l
1.28
89
699
6
13
4.75
2.29
1.0
1.1
—
—
—
0
0
51
353
1.65
2.18
5.9
3.8
15.32
59.45
mg/mmol
0.41
38
217
126
1089
1.76
2.18
5.5
4.5
2.08
1.99
mu/l
0.31
119
966
10
36
2.89
2.18
1.0
1.1
—
—
—
0
0
7
19
3.80
2.17
3.1
1.5
—
—
—
0
0
6
14
4.41
2.17
2.3
1.8
—
—
—
0
0
6
14
4.41
2.17
1.8
1.6
—
—
—
0
0
35
220
1.76
2.12
3.7
2.8
0.63
0.95
e6/l
0.52
20
130
136
1206
1.88
2.10
37.4
13.5
23.19
24.09
mg/l
0.12
123
944
56
404
1.60
2.01
4.9
3.1
2.35
2.36
mmol/l
0.20
48
346
6
16
3.85
1.95
2.3
1.7
—
—
—
0
0
22
123
1.92
1.92
6.5
2.9
—
—
—
0
0
8
28
2.95
1.89
1.9
1.3
—
—
—
0
0
28
171
1.77
1.86
1.3
1.2
50.05
13.95
u/ml
—
6
76
6
17
3.62
1.85
2.8
2.0
—
—
—
0
0
6
17
3.62
1.85
2.8
2.0
—
—
—
0
0
5
12
4.26
1.83
1.4
1.2
—
—
—
0
0
7
23
3.13
1.82
1.9
1.6
—
—
—
0
0
6
18
3.42
1.76
1.0
1.2
—
—
—
0
0
7
24
3.00
1.74
1.0
1.1
—
—
—
0
0
5
13
3.93
1.73
1.6
1.2
—
—
—
0
0
7
25
2.88
1.67
3.7
1.5
—
—
—
0
0
5
14
3.65
1.63
1.2
1.1
—
—
—
0
0
88
732
1.45
1.51
3.2
3.0
—
—
—
0
0
9
37
2.52
1.50
1.9
1.1
0.26
0.23
g/l
—
9
37
9
39
2.38
1.45
1.9
1.2
1.25
1.13
g/l
—
9
39
5
16
3.19
1.45
3.0
3.3
6.72
3.13
nmol/l
—
5
16
74
602
1.43
1.40
6.4
5.0
0.00
0.00
estimate
-0.00
21
118
6
23
2.67
1.38
1.3
1.3
—
—
—
0
0
9
44
2.11
1.29
1.1
1.3
—
—
—
0
0
9
44
2.11
1.29
1.1
1.3
—
—
—
0
0
8
35
2.35
1.29
1.4
1.3
—
—
—
0
0
74
609
1.40
1.29
4.5
3.7
0.00
0.00
estimate
-0.00
22
125
74
613
1.39
1.22
4.5
3.7
0.00
0.00
estimate
-0.00
21
110
20
126
1.67
1.21
1.7
1.5
1.49
1.44
%
0.19
15
112
7
31
2.31
1.12
1.0
1.3
—
—
—
0
0
18
114
1.65
1.08
2.1
2.3
11.55
5.16
ug/l
0.52
13
94
16
98
1.70
1.08
14.9
2.4
1.21
1.22
mmol/l
0.53
16
85
142
1337
1.58
0.98
54.1
19.7
36.54
40.05
%
8.40
134
1246
30
221
1.44
0.95
4.8
2.9
2.51
2.45
mmol/l
1.54
23
192
6
27
2.27
0.94
1.2
1.1
—
—
—
0
0
43
340
1.36
0.91
4.5
3.9
0.00
0.00
estimate
-0.00
19
117
6
32
1.91
0.82
2.3
1.4
—
—
—
0
0
6
34
1.79
0.77
2.3
2.4
—
—
—
0
0
5
27
1.88
0.69
2.0
1.1
—
—
—
0
0
121
1129
1.30
0.69
33.8
12.4
74.01
80.02
ml/min/173m2
1.38
105
905
124
1164
1.30
0.65
5.3
4.8
2.46
2.64
mmol/l
1.36
115
1054
8
53
1.54
0.59
4.9
4.1
25.96
24.84
mmol/l
—
8
53
11
73
1.54
0.58
1.1
1.5
—
—
—
0
0
28
223
1.31
0.57
3.1
2.9
1.21
0.78
ug/l
0.33
18
153
115
1083
1.22
0.50
4.3
3.9
1.40
1.24
mmol/l
1.38
105
982
7
51
1.39
0.44
3.6
2.4
1.57
1.11
%
—
7
51
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
5
35
1.44
0.39
1.4
1.2
—
—
—
0
0
12
158
0.74
0.39
8.5
7.5
—
—
—
0
0
118
1125
1.19
0.39
4.6
4.3
1.37
1.47
mmol/l
1.55
110
1018
119
1136
1.19
0.38
4.6
4.3
4.30
4.52
mmol/l
1.50
110
1035
53
476
1.17
0.37
4.6
3.7
—
—
—
0
0
118
1132
1.16
0.32
6.0
4.6
5.96
5.92
mmol/l
0.10
109
1017
7
52
1.36
0.31
4.6
5.7
36.10
44.38
%
—
7
52
7
57
1.24
0.29
1.4
1.5
—
—
—
0
0
11
87
1.28
0.25
4.8
3.7
54.00
61.77
ml/min/173m2
—
5
31
15
176
0.84
0.21
1.6
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
20
227
0.86
0.19
1.8
1.5
—
—
—
0
0
7
58
1.22
0.18
1.9
1.9
—
—
—
0
0
33
313
1.07
0.08
3.5
4.6
24.71
21.95
%
0.28
15
166
12
133
0.89
0.08
2.4
2.2
—
—
—
0
0
8
77
1.04
0.07
2.0
1.9
—
—
—
0
0
40
394
1.02
0.00
5.6
5.2
2.15
2.58
ug/l
0.36
31
345
12
119
1.01
0.00
2.4
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
74
0.94
-0.00
1.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.30
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
81
0.99
-0.00
1.6
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_ACQPUREREDCLLAPLASIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQPUREREDCLLAPLASIA | 2.385 [1.8, 3.16] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.612 |
During the follow-up period (1.1.1998 — 31.12.2019), 214 out of 643 females with D3_ACQPUREREDCLLAPLASIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQPUREREDCLLAPLASIA | 3.507 [2.19, 5.62] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 220 out of 570 males with D3_ACQPUREREDCLLAPLASIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_ACQPUREREDCLLAPLASIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.271% | 0.578% |
| 5 | 1.616% | 3.729% |
| 10 | 4.04% | 9.649% |
| 15 | 7.368% | 16.673% |
| 20 | 12.727% | 26.796% |
Relationships between endpoints
↥Index endpoint: D3_ACQPUREREDCLLAPLASIA – Acquired pure red cell aplasia [erythroblastopenia]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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