Drug-induced gout

DRUGADVERS_GOUT

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M10.2# 1 out of 7 registries used, show all original rules.	160
4. Check minimum number of events None	160
5. Include endpoints None	160
6. Filter based on genotype QC (FinnGen only)	158

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	DRUGADVERS_GOUT
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M102
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Drug-induced gout based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2039	925	1082
Only index persons	1283	594	689
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.03
Only index persons	0.02	0.02	0.03
Median age at first event (years)
Whole population	75.80	79.20	72.91
Only index persons	74.55	78.74	70.93

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	158	49	109
Unadjusted period prevalence (%)	0.04	0.02	0.05
Median age at first event (years)	70.49	74.41	68.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
160: Matched controls
1600

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M10.2

ICD-10 Finland

Drug-induced gout

+∞

229.2

160

M04AA01

ATC

allopurinol; systemic

65.1

119.6

145

207

M10.9

ICD-10 Finland

Gout, unspecified

17.7

72.1

M10.0

ICD-10 Finland

Idiopathic gout

16.3

40.7

I50.9

ICD-10 Finland

Heart failure, unspecified

6.0

29.0

299

I50.0

ICD-10 Finland

Congestive heart failure

6.6

28.7

139

212

Kela drug reimbursment

Gout

13.4

28.4

C03CA01

ATC

furosemide; systemic

8.0

27.7

132

592

I50.1

ICD-10 Finland

Left ventricular failure

8.3

27.2

B01AA03

ATC

warfarin; systemic

5.5

25.7

350

C03DA01

ATC

spironolactone; oral

5.5

22.2

151

C01AA05

ATC

digoxin; systemic

4.8

17.5

143

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

5.7

17.4

M10

ICD-10 Finland

Gout

7.0

16.7

A46

ICD-10 Finland

Erysipelas

4.3

16.6

192

I48

ICD-10 Finland

Atrial fibrillation and flutter

3.7

14.9

407

N17.9

ICD-10 Finland

Acute renal failure, unspecified

6.6

14.7

205

Kela drug reimbursment

Chronic hypertension

3.6

14.5

459

201

Kela drug reimbursment

Chronic cardiac insufficiency

4.9

14.3

M13.9

ICD-10 Finland

Arthritis, unspecified

5.7

13.9

C07AB07

ATC

bisoprolol; oral

4.0

13.2

124

737

C03AA03

ATC

hydrochlorothiazide; oral

4.5

13.2

104

C09AA02

ATC

enalapril; systemic

3.4

12.7

298

C03EB01

ATC

furosemide and potassium-sparing agents; systemic

5.3

12.2

H02AB06

ATC

prednisolone; systemic

3.4

12.1

107

599

R06.0

ICD-10 Finland

Dyspnoea

3.1

10.9

335

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

5.7

10.1

I11.0

ICD-10 Finland

Hypertensive heart disease with (congestive) heart failure

5.6

9.9

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

2.9

9.8

375

C01DA14

ATC

isosorbide mononitrate; oral

2.9

9.3

322

I25.2

ICD-10 Finland

Old myocardial infarction

3.6

9.1

116

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

5.4

9.1

C09BA02

ATC

enalapril and diuretics; systemic

3.6

9.0

111

C01DA08

ATC

isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal

2.7

8.9

437

R60.0

ICD-10 Finland

Localized oedema

3.4

8.7

125

I50

ICD-10 Finland

Heart failure

4.9

8.1

I25.9

ICD-10 Finland

Chronic ischaemic heart disease, unspecified

2.9

7.8

196

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

3.8

7.8

207

Kela drug reimbursment

Chronic arrhythmias

2.7

7.6

239

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.7

7.6

282

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

8.3

7.6

M04AA03

ATC

febuxostat; oral

83.8

7.5

288

Kela drug reimbursment

Febuxostat

83.8

7.5

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

3.0

7.4

162

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

4.3

7.2

103

Kela drug reimbursment

Diabetes, insulin-treated

2.5

7.2

397

E11.00

ICD-10 Finland

Non-insulin dependent diabetes diabetic hypoglycaemic coma

4.2

7.1

Angiography of the heart and coronary arteries

3.3

6.9

101

C07AG02

ATC

carvedilol; oral

3.6

6.9

M01AB01

ATC

indometacin; systemic, rectal

3.3

6.8

J96.1

ICD-10 Finland

Chronic respiratory failure

8.4

6.8

206

Kela drug reimbursment

Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease

2.4

6.7

359

J44.8

ICD-10 Finland

Other specified chronic obstructive pulmonary disease

2.8

6.6

178

C02EA02, ,

ATC

3.6

6.6

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.0

6.6

128

E66.00

ICD-10 Finland

Metabolic syndrome

5.7

6.6

N18.8

ICD-10 Finland

Other chronic renal failure

6.5

R03AK06

ATC

salmeterol and fluticasone; inhalant

2.7

6.5

180

E66.9

ICD-10 Finland

Obesity, unspecified

8.7

6.5

C02AC05

ATC

moxonidine; oral

4.2

6.5

I25.5

ICD-10 Finland

Ischaemic cardiomyopathy

7.6

6.4

R03BB04

ATC

tiotropium bromide; inhalant

2.8

6.2

157

A11CC03

ATC

alfacalcidol; systemic

7.2

6.2

I25.1

ICD-10 Finland

Atherosclerotic heart disease

2.3

6.2

427

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.6

6.2

198

J01DB01

ATC

cefalexin; oral

2.8

6.1

131

990

Z01.8

ICD-10 Finland

Other specified special examinations

2.6

6.1

179

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3026493) Urate [Moles/volume] in Serum or Plasma

328

5.38

25.25

6.0

3.0

7574.25

8850.01

umol/l

0.08

263

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

8.82

19.73

1.2

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

162

2.96

7.42

2.4

1.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

163

2.84

6.79

2.5

1.9

—

(3000991) Gas panel - Venous blood

112

3.07

6.36

12.0

8.0

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

150

2.81

6.27

1.4

1.3

77.32

43.63

iu/ml

0.36

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

134

2.84

6.02

1.4

1.3

16.53

24.27

u/ml

0.17

(3020891) Body temperature

3.67

5.95

7.0

4.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

240

2.43

5.75

2.7

1.9

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

193

2.51

5.58

10.5

6.4

104.12

104.05

mmol/l

0.03

193

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.61

5.04

2.0

2.6

—

(3000475) Leukocytes [#/volume] in Synovial fluid

5.19

4.94

1.4

1.5

33717.78

5681.42

e6/l

—

(3021788) Differential panel - Synovial fluid

7.03

4.54

1.1

1.5

—

(3042936) Bacteria identified in Isolate by Culture

197

2.30

4.47

2.1

2.0

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.47

4.12

1.8

1.4

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

500

1.94

4.07

6.6

3.4

3198.98

1881.22

ng/l

1.85

423

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

177

2.25

3.98

9.9

6.1

5.32

5.05

kpa

0.62

168

(3027801) Oxygen [Partial pressure] in Arterial blood

177

2.25

3.98

9.9

6.1

8.88

11.24

kpa

5.04

169

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.94

3.91

1.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.94

3.91

1.6

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

4.55

3.91

1.5

1.7

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

5.54

3.89

1.6

1.4

—

(3037522) Nuclear Ab [Titer] in Serum

110

2.51

3.86

1.3

993.33

634.48

titre

—

(3016502) Oxygen saturation in Arterial blood

158

2.28

3.84

10.3

6.7

90.92

95.01

0.87

153

(3022217) INR in Platelet poor plasma by Coagulation assay

694

1.91

3.83

40.6

17.6

1.64

1.32

inr

1.81

203

(3017704) Immunofixation for Urine

12.39

3.79

1.2

1.0

—

(3023368) Bacteria identified in Blood by Culture

432

1.90

3.71

6.6

4.3

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

100

2.52

3.63

11.5

6.2

24.64

24.33

mmol/l

0.10

(3037121) Protein [Mass/volume] in Urine

3.24

3.63

2.2

3.5

0.53

0.17

g/l

—

(3019060) Gas panel - Arterial blood

114

2.41

3.58

7.0

3.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

149

2.25

3.55

2.3

1.8

—

(3000850) Epithelial cells [#/volume] in Urine

305

1.93

3.43

5.6

2.9

3.65

4.05

e6/l

0.10

267

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

4.37

3.25

1.1

1.7

0.29

0.25

g/l

—

(3003396) Base excess in Arterial blood by calculation

177

2.09

3.22

10.5

6.3

1.81

1.21

mmol/l

0.24

139

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

4.19

3.14

1.1

1.8

1.41

1.15

g/l

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

3.06

3.10

3.5

1.9

0.48

0.31

u/ml

—

(40768797) Stomach Pathology biopsy report

150

2.14

3.10

1.4

1.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

636

1.76

3.09

6.7

6.3

13.37

12.18

umol/l

0.48

595

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

365

1.82

3.09

4.0

2.0

5.27

3.20

mg/l

1.93

313

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

497

1.77

3.09

6.5

3.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.40

2.94

1.7

1.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

105

2.27

2.85

1.9

1.6

—

(3026782) Osmolality of Urine

307

1.81

2.78

6.4

3.4

546.07

564.10

mosm/kgh2o

0.23

256

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

5.17

2.76

1.4

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

6.18

2.72

2.8

1.6

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

3.91

2.71

1.6

1.5

—

(3045414) Leukocytes [Presence] in Urine

3.30

2.70

2.3

2.0

—

(40758558) Short blood count panel - Blood

285

1.81

2.68

7.8

6.6

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.50

2.65

6.9

2.8

1.42

1.16

0.53

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

4.83

2.62

1.0

1.1

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

3.75

2.62

1.8

1.5

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

4.15

2.60

1.3

1.1

—

(3045424) Erythrocytes [Presence] in Urine

5.15

2.42

1.0

1.2

—

(3044941) Cell count panel - Synovial fluid

5.15

2.42

1.0

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.74

2.42

1.2

1.4

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

6.41

2.39

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

4.75

2.29

1.0

1.4

—

(40761535) Cells panel - Urine sediment

109

2.07

2.23

4.1

4.0

—

(3035350) Ketones [Presence] in Urine by Test strip

564

1.58

2.12

6.4

4.5

0.00

estimate

-0.00

123

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

296

1.67

2.09

3.7

2.5

—

(36304419) Bacteria [Presence] in Urine

358

1.62

2.05

7.1

3.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.44

1.99

1.4

1.1

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.06

1.96

1.9

1.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

572

1.55

1.96

6.7

4.7

42.77

56.42

ng/l

0.67

449

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

4.65

1.95

3.2

2.0

—

(3008898) HLA-B27 [Presence]

3.85

1.95

1.0

1.1

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.26

1.94

7.6

2.6

0.89

0.66

0.75

(3018095) Leukocytes [#/volume] in Urine

471

1.56

1.93

7.6

4.2

45.50

137.67

e6/l

1.53

359

(40760888) Immunoglobulin light chains.free panel - Serum

2.95

1.89

2.3

2.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

548

1.53

1.87

3.6

2.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

253

1.66

1.86

5.5

4.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.62

1.85

1.5

1.4

—

(3044927) Protein electrophoresis panel - Urine

4.26

1.83

1.2

—

(3000093) Morphology [Interpretation] in Blood Narrative

4.26

1.83

1.0

1.2

—

(3009508) Creatinine [Moles/volume] in Urine

385

1.56

1.82

4.8

3.2

7.08

7.32

mmol/l

0.17

302

(3020682) Albumin/Creatinine [Ratio] in Urine

412

1.55

1.82

5.8

3.9

46.26

9.36

mg/mmol

1.49

261

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.19

1.82

1.9

2.6

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

3.13

1.82

4.4

3.1

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

247

1.65

1.79

1.6

1.10

1.70

mg/l

1.32

192

(3030905) Polymorphonuclear cells [#/volume] in Blood

3.42

1.76

2.3

1.6

4.59

5.04

e9/l

—

(3012516) Albumin [Mass/volume] in Urine

388

1.55

1.76

4.4

3.1

222.57

69.69

mg/l

1.01

253

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

2.39

1.75

2.4

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

3.00

1.74

1.9

1.7

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

3.00

1.74

1.9

1.7

—

(3035637) Corticotropin [Mass/volume] in Plasma

3.93

1.73

1.0

1.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

105

1.92

1.72

2.7

2.1

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.66

1.68

2.4

1.5

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.66

1.68

2.4

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

520

1.50

1.68

9.3

6.5

—

(3022806) Fractional oxyhemoglobin in Capillary blood

3.24

1.67

3.7

1.8

86.18

89.45

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

3.24

1.67

4.3

4.9

—

(3023183) Ammonium ion [Moles/volume] in Plasma

2.88

1.67

1.9

1.7

24.29

27.10

umol/l

—

(3009261) Glucose [Presence] in Urine by Test strip

569

1.48

1.64

6.6

4.5

0.00

estimate

-0.00

104

(3002582) Erythrocytes [#/volume] in Urine

439

1.50

1.63

7.2

3.6

14.53

233.18

e6/l

0.87

345

(3013650) Neutrophils [#/volume] in Blood by Automated count

656

1.48

1.63

10.1

9.3

5.65

4.37

e9/l

2.12

571

(3021601) Nitrite [Presence] in Urine by Test strip

562

1.47

1.60

8.0

6.0

0.00

estimate

-0.00

109

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

3.08

1.59

2.3

1.8

61.50

57.85

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.09

1.53

13.3

9.4

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

3.40

1.53

1.6

1.3

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

3.40

1.53

1.6

1.1

—

(4200892) Spirometry reversibility

1.97

1.50

1.5

1.3

—

(3015736) pH of Urine

437

1.47

1.49

5.0

4.3

—

5.74

—

(3044640) Blood type and Crossmatch panel - Blood

405

1.46

1.40

4.4

2.8

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.56

1.31

1.5

1.7

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.29

1.26

1.0

1.3

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.29

1.26

1.0

1.3

—

(3023419) Bacteria identified in Sputum by Culture

2.45

1.25

3.5

2.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.68

1.22

1.4

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

167

1.59

1.22

1.6

1.4

3.12

3.05

g/l

0.03

(3021901) Oxygen saturation in Capillary blood

2.16

1.20

4.7

2.7

—

(3022313) Gas panel - Capillary blood

1.88

1.19

2.5

2.9

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

367

0.65

1.18

3.0

3.2

0.88

ug/l

0.00

250

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.78

1.16

3.3

1.5

—

(3012441) Differential panel - Pleural fluid

2.55

1.16

1.2

1.5

—

(3019150) Specific gravity of Urine by Refractometry

257

1.46

1.12

6.8

5.2

1.02

kg/l

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

514

0.70

1.11

3.3

4.7

20.91

22.22

0.22

266

(3004809) Band form neutrophils/100 leukocytes in Blood

2.42

1.10

1.0

4.1

1.40

0.83

—

(3029937) Albumin [Presence] in Urine by Test strip

330

1.41

1.09

7.3

4.7

0.00

estimate

-0.00

104

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

643

1.35

1.06

13.7

6.3

1.20

1.21

mmol/l

0.20

540

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

2.31

1.04

1.6

1.8

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

625

1.34

1.04

4.5

3.0

81.65

55.72

u/l

1.64

562

(1616796) Gas panel - Central venous blood

2.04

1.01

9.7

3.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.21

0.98

4.2

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.99

0.98

1.0

1.3

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

586

1.31

0.90

15.7

5.6

1.20

mmol/l

0.01

518

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.95

0.90

1.0

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

1032

0.76

0.89

33.4

18.3

58.07

70.61

ml/min/173m2

4.91

859

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

147

1.49

0.85

25.3

9.6

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.97

0.85

1.3

1.1

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.63

0.84

4.8

3.8

47.22

53.83

ml/min/173m2

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.74

0.82

2.1

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

449

1.31

0.81

7.2

4.9

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.79

0.0

1.5

—

(40768804) Tissue Pathology biopsy report

457

0.75

0.77

2.5

2.2

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

2.12

0.75

1.0

1.1

—

1.66

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.12

0.75

2.0

1.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.12

0.75

1.0

1.2

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.03

0.73

1.6

1.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.88

0.69

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.81

0.66

4.2

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.52

0.66

3.0

1.4

—

(3017181) Myelocytes/100 leukocytes in Blood

104

1.49

0.65

5.3

4.5

0.50

0.92

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

1023

0.80

0.65

5.1

4.8

1.16

1.41

mmol/l

7.60

907

(3013707) Erythrocyte sedimentation rate by Westergren method

845

1.24

0.64

7.8

4.3

27.77

15.53

mm/h

4.58

761

(3021440) Promyelocytes/100 leukocytes in Blood

1.50

0.64

5.6

4.6

0.00

0.10

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.69

0.62

1.8

1.6

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

641

0.81

0.61

4.7

5.5

3.87

3.14

ug/l

0.24

562

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

1000

0.81

0.61

4.6

4.4

2.47

2.08

mu/l

0.84

855

(3022145) Colonoscopy Study observation

123

1.43

0.61

1.3

—

(1761868) Lipid panel - Serum or Plasma

303

0.76

0.58

3.1

3.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

100

1075

0.81

0.57

5.9

5.5

2.19

2.48

mmol/l

2.84

954

(3009542) Hematocrit [Volume Fraction] of Blood

112

1190

0.80

0.57

56.2

27.5

37.32

39.21

1.29

104

1103

(3022621) pH of Urine by Test strip

1.50

0.56

5.2

2.9

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.53

0.55

2.1

1.9

—

(4034850) Laboratory test

1.60

0.55

26.8

15.5

—

(3021589) Normoblasts [#/volume] in Blood

499

1.22

0.54

20.4

11.2

0.00

0.01

e9/l

0.17

414

(3020564) Creatinine [Moles/volume] in Serum or Plasma

108

1149

0.82

0.54

47.4

22.6

121.67

88.22

umol/l

4.74

108

1149

(3037756) Immunofixation for Serum or Plasma

1.56

0.53

1.8

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

109

1.42

0.53

4.5

1.5

—

(3002179) Metamyelocytes/100 leukocytes in Blood

1.45

0.52

4.8

4.4

0.17

0.40

—

(3049717) Cytology report of Urine Cyto stain

1.41

0.51

2.9

3.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

100

1069

0.83

0.51

5.4

5.2

6.51

6.19

mmol/l

1.23

941

(3025159) Blasts/100 leukocytes in Blood

1.43

0.50

6.0

4.6

0.00

0.26

—

(3037467) Urinalysis macro (dipstick) panel - Urine

819

1.20

0.49

7.5

4.6

—

(3052851) Hemolysis interference index of Serum or Plasma

1.55

0.49

4.7

3.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.40

0.45

1.2

1.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

995

0.84

0.45

4.5

4.4

1.58

1.25

mmol/l

3.83

879

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

1032

0.85

0.43

5.1

4.9

3.91

4.31

mmol/l

3.53

927

(3026008) Bacteria identified in Urine by Culture

433

1.19

0.42

4.9

3.6

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.41

0.0

1.4

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.4

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.4

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.4

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.40

0.0

1.2

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

110

1155

0.85

0.39

16.5

11.3

23.92

24.30

u/l

0.10

104

1101

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.39

0.0

1.2

—

1.79

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.39

0.0

1.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.39

0.0

1.4

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.39

0.0

1.3

—

15.79

—

(3044889) 12 lead EKG panel

819

0.86

0.38

6.9

4.6

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.48

0.36

1.3

1.8

—

(3000330) Specific gravity of Urine by Test strip

1.39

0.35

4.6

5.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

229

1.22

0.35

5.2

3.3

1.90

1.81

e6/l

0.03

142

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.35

0.34

8.0

2.4

2.93

1.76

mg/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.32

0.33

1.5

1.3

—

(3018418) pH of Serum or Plasma

385

1.16

0.31

11.9

3.9

7.40

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

1.29

0.30

2.4

1.7

1.31

0.39

g/l

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.29

0.30

2.1

1.7

—

(1761482) Bacteria [#/volume] in Urine by Culture

1.24

0.29

3.4

5.5

—

(3000492) Spirometry study

1.32

0.29

2.4

1.5

—

(3003694) ABO and Rh group [Type] in Blood

267

0.84

0.28

1.2

1.3

—

(40761511) CBC panel - Blood by Automated count

108

1122

0.88

0.26

36.2

18.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

229

1.16

0.23

4.1

3.0

0.54

0.91

e6/l

0.60

141

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.23

0.22

1.4

1.2

—

(3002256) Pathology report gross observation

145

0.81

0.22

1.3

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

145

1.19

0.21

6.6

4.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.6

—

70.30

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

209.60

—

(3014271) Vancomycin [Susceptibility]

0.00

0.21

0.0

2.5

—

(4035726) Immunohistochemistry procedure

1.23

0.20

1.3

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

1.23

0.20

2.5

1.7

1.37

0.00

g/l

—

(3021960) Folate [Moles/volume] in Serum or Plasma

349

1.12

0.19

2.1

1.6

27.68

20.20

nmol/l

0.29

290

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.25

0.19

2.9

1.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

467

1.10

0.19

2.8

2.4

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.19

0.18

2.4

1.6

2.91

3.09

g/l

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

101

1039

0.92

0.15

9.0

6.9

43.81

41.62

mmol/mol

1.04

942

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

779

0.93

0.14

3.7

3.5

14.82

15.07

pmol/l

0.35

661

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

109

1115

0.93

0.13

41.8

18.9

25.22

26.92

mg/l

0.32

103

939

(3041096) Erythrocytes [Presence] in Urine by Automated

319

1.08

0.11

6.9

4.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

542

0.94

0.10

2.4

2.1

84.74

90.40

pmol/l

0.53

291

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

1.11

0.10

2.8

1.7

0.00

g/l

—

(3002385) Erythrocyte distribution width [Ratio]

912

0.95

0.10

43.9

23.0

16.23

15.42

0.76

895

(3019225) pH of Specimen

126

1.12

0.09

5.2

3.9

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.08

0.08

2.4

1.6

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.08

0.08

2.4

1.6

6.54

7.36

g/l

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.08

0.08

2.4

1.6

4.59

3.66

g/l

—

(3000494) Fungus identified in Specimen by Culture

150

1.07

0.04

2.2

1.4

—

(40761536) Microorganisms panel - Urine sediment

101

1.10

0.04

11.5

3.9

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

190

1.06

0.04

1.1

0.65

1.16

u/ml

—

(3013512) EKG study

394

1.02

0.00

5.3

4.7

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.3

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.9

—

15.11

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.0

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.1

—

3.49

—

(3025941) Bacteria identified in Stool by Culture

1.00

0.00

1.0

1.4

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.4

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

-0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.4

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.6

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

22.72

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(3014891) Appearance of Pleural fluid

0.00

-0.00

0.0

1.2

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.4

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(40760548) Muscle specific receptor tyrosine kinase Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

1.16

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

30.20

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.0

—

10.38

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

19.60

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.4

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.4

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.96

-0.00

1.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(3048689) Calprotectin [Mass/mass] in Stool

0.97

-0.00

1.7

1.9

111.00

246.77

ug/g

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

1.97

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

5.2

—

237.11

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

14.26

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.1

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

-0.00

0.0

1.7

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

184.76

—

(36660697) Celiac disease serology panel - Serum

0.91

-0.00

1.0

1.1

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.02

-0.00

2.6

1.3

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.3

—

(3017732) Neutrophils [#/volume] in Blood

0.86

-0.00

4.8

2.9

4.71

7.77

e9/l

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

4.6

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.3

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.3

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

4.6

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_GOUT and mortality.

Females

Parameter	HR [95% CI]	p-value
DRUGADVERS_GOUT	2.636 [2.17, 3.21]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.103

During the follow-up period (1.1.1998 — 31.12.2019), 583 out of 777 females with DRUGADVERS_GOUT died.

Males

Parameter	HR [95% CI]	p-value
DRUGADVERS_GOUT	2.856 [2.31, 3.53]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 683 out of 935 males with DRUGADVERS_GOUT died.

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_GOUT.

N-year risk	Females	Males
1	0.264%	0.645%
5	1.546%	3.143%
10	3.113%	7.409%
15	6.06%	14.055%
20	11.075%	22.563%

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_GOUT – Drug-induced gout

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced gout

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints