Drug-induced gout

DRUGADVERS_GOUT

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M10.2# 1 out of 7 registries used, show all original rules.	156
4. Check minimum number of events None	156
5. Include endpoints None	156
6. Filter based on genotype QC (FinnGen only)	156

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	DRUGADVERS_GOUT
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M102
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Drug-induced gout based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2039	925	1082
Only index persons	1283	594	689
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.03
Only index persons	0.02	0.02	0.03
Median age at first event (years)
Whole population	75.80	79.20	72.91
Only index persons	74.55	78.74	70.93

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	156	50	106
Unadjusted period prevalence (%)	0.04	0.02	0.05
Median age at first event (years)	69.89	73.16	68.36

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
144: Matched controls
1439

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M10.2

ICD-10 Finland

Drug-induced gout

+∞

208.1

144

M04AA01

ATC

allopurinol; systemic

47.0

78.8

125

176

M10.9

ICD-10 Finland

Gout, unspecified

14.3

35.3

C03CA01

ATC

furosemide; systemic

8.0

26.5

117

505

I50.9

ICD-10 Finland

Heart failure, unspecified

6.9

25.0

236

M10.0

ICD-10 Finland

Idiopathic gout

18.0

24.0

I50.0

ICD-10 Finland

Congestive heart failure

6.8

19.1

120

B01AA03

ATC

warfarin; systemic

5.0

18.6

351

212

Kela drug reimbursment

Gout

13.6

16.1

C03DA01

ATC

spironolactone; oral

5.3

14.8

139

I50.1

ICD-10 Finland

Left ventricular failure

6.8

13.8

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

6.7

13.5

205

Kela drug reimbursment

Chronic hypertension

3.5

12.0

424

H02AB06

ATC

prednisolone; systemic

3.5

11.7

530

A46

ICD-10 Finland

Erysipelas

4.3

11.5

155

I48

ICD-10 Finland

Atrial fibrillation and flutter

3.5

11.5

396

C01AA05

ATC

digoxin; systemic

4.0

10.5

154

C01DA14

ATC

isosorbide mononitrate; oral

3.3

9.7

265

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

3.2

9.6

307

C07AB07

ATC

bisoprolol; oral

3.3

9.6

108

687

M13.9

ICD-10 Finland

Arthritis, unspecified

5.7

9.3

R06.0

ICD-10 Finland

Dyspnoea

3.2

9.2

274

C01DA08

ATC

isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal

3.1

9.2

354

201

Kela drug reimbursment

Chronic cardiac insufficiency

4.6

8.9

C09AA02

ATC

enalapril; systemic

3.1

8.8

276

E66.00

ICD-10 Finland

Metabolic syndrome

8.8

8.7

J44.8

ICD-10 Finland

Other specified chronic obstructive pulmonary disease

3.8

8.4

124

C03EB01

ATC

furosemide and potassium-sparing agents; systemic

5.1

7.9

E66.9

ICD-10 Finland

Obesity, unspecified

12.8

7.7

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

7.6

A11CC03

ATC

alfacalcidol; systemic

10.2

7.5

M10

ICD-10 Finland

Gout

5.2

7.3

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

3.0

7.2

214

E11.00

ICD-10 Finland

Non-insulin dependent diabetes diabetic hypoglycaemic coma

5.9

7.1

R03BB04

ATC

tiotropium bromide; inhalant

3.4

7.0

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

7.8

6.9

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

4.7

6.9

C03AA03

ATC

hydrochlorothiazide; oral

3.7

6.8

103

Kela drug reimbursment

Diabetes, insulin-treated

2.6

6.8

336

C02AC05

ATC

moxonidine; oral

6.1

6.5

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

4.3

6.4

207

Kela drug reimbursment

Chronic arrhythmias

2.8

6.3

205

C09BA02

ATC

enalapril and diuretics; systemic

3.4

6.2

103

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

3.3

6.1

120

T90

ICPC

Diabetes non-insulin dependent

2.7

6.1

240

R03AK06

ATC

salmeterol and fluticasone; inhalant

3.1

6.1

135

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3026493) Urate [Moles/volume] in Serum or Plasma

316

5.51

25.35

6.0

3.0

7840.25

9184.86

umol/l

0.08

253

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

8.57

17.94

1.2

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

154

2.94

7.03

2.5

1.8

—

(3002032) Base excess in Venous blood by calculation

126

3.05

6.76

6.4

3.9

2.35

1.67

mmol/l

0.50

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

155

2.82

6.41

2.6

1.9

—

(3020891) Body temperature

3.88

6.40

7.1

4.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

132

2.90

6.21

1.4

1.3

16.53

24.27

u/ml

0.17

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

145

2.82

6.17

1.4

1.3

81.17

45.00

iu/ml

0.37

(3000991) Gas panel - Venous blood

109

3.04

6.08

10.6

8.1

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.80

5.62

1.8

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

231

2.41

5.45

2.8

1.9

—

(3012544) pH of Venous blood

129

2.75

5.39

6.7

3.9

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.62

5.05

2.0

2.6

—

(3042936) Bacteria identified in Isolate by Culture

190

2.32

4.48

2.1

2.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

4.31

4.24

1.5

1.7

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

3.74

4.15

1.7

1.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

3.74

4.15

1.7

1.6

—

(3019060) Gas panel - Arterial blood

107

2.59

4.09

7.0

3.6

—

(3021788) Differential panel - Synovial fluid

6.75

4.04

1.1

1.5

—

(3037522) Nuclear Ab [Titer] in Serum

108

2.57

4.01

1.3

993.33

645.71

titre

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

170

2.28

3.98

8.7

6.1

5.36

5.04

kpa

0.78

161

(3027801) Oxygen [Partial pressure] in Arterial blood

170

2.28

3.98

8.7

6.1

8.77

11.19

kpa

5.42

162

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

4.38

3.95

1.1

1.8

0.29

0.25

g/l

—

(3023368) Bacteria identified in Blood by Culture

419

1.95

3.88

6.7

4.3

—

(3017704) Immunofixation for Urine

12.40

3.79

1.2

1.0

—

(3016502) Oxygen saturation in Arterial blood

152

2.30

3.79

9.0

6.7

90.74

95.12

0.91

147

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

4.21

3.76

1.1

1.8

1.41

1.15

g/l

—

(3037121) Protein [Mass/volume] in Urine

3.24

3.63

2.2

3.5

0.53

0.17

g/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

489

1.88

3.61

6.6

3.4

3257.05

1897.23

ng/l

1.83

413

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

5.24

3.42

1.7

1.3

—

(40768797) Stomach Pathology biopsy report

145

2.23

3.38

1.4

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

147

2.19

3.27

2.3

1.8

—

(3003396) Base excess in Arterial blood by calculation

170

2.11

3.21

9.2

6.3

2.25

1.08

mmol/l

0.59

133

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.46

3.09

1.8

1.4

—

(3000850) Epithelial cells [#/volume] in Urine

291

1.88

3.06

5.8

2.8

3.74

4.30

e6/l

0.14

251

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

102

2.35

3.04

1.9

1.6

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

615

1.75

2.95

6.6

6.2

13.36

12.23

umol/l

0.43

574

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

5.58

2.90

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

478

1.75

2.89

6.7

3.5

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.59

2.81

6.9

2.8

1.42

1.18

0.47

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

5.18

2.76

1.0

1.1

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

6.19

2.72

2.8

1.6

—

(3043409) Potassium [Moles/volume] in Arterial blood

2.70

8.4

3.4

3.97

4.05

mmol/l

0.22

(3026782) Osmolality of Urine

287

1.80

2.63

6.6

3.1

527.29

567.10

mosm/kgh2o

0.81

239

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

4.16

2.60

1.3

1.1

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

2.81

2.51

3.5

1.9

0.48

0.31

u/ml

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.81

2.51

1.3

1.4

—

(3045424) Erythrocytes [Presence] in Urine

5.15

2.42

1.0

1.2

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

6.41

2.39

1.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

3.61

2.30

1.6

1.5

—

(21494890) Protein electrophoresis panel - 24 hour Urine

4.75

2.29

1.0

1.4

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

5.70

2.23

3.2

2.1

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

3.46

2.21

1.9

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

234

1.76

2.20

1.6

1.10

1.76

mg/l

1.42

182

(40758558) Short blood count panel - Blood

276

1.71

2.19

7.1

6.5

—

(3032080) INR in Blood by Coagulation assay

563

1.60

2.17

24.1

10.1

1.61

1.32

inr

1.19

159

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

288

1.68

2.08

3.8

2.5

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.19

2.04

1.9

1.7

—

(42870588) Differential panel, method unspecified - Blood

377

1.61

2.03

7.9

5.1

—

(40761535) Cells panel - Urine sediment

107

2.00

1.97

4.3

4.1

—

(3044941) Cell count panel - Synovial fluid

4.66

1.95

1.0

1.3

—

(3000093) Morphology [Interpretation] in Blood Narrative

4.66

1.95

1.0

1.2

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.85

1.95

1.5

1.3

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.95

1.89

2.3

2.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

559

1.53

1.86

6.8

4.7

43.28

57.44

ng/l

0.68

436

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

531

1.54

1.85

5.2

4.7

—

(3044927) Protein electrophoresis panel - Urine

4.27

1.83

1.2

—

(3035637) Corticotropin [Mass/volume] in Plasma

4.27

1.83

1.0

1.5

—

(3045414) Leukocytes [Presence] in Urine

2.67

1.83

2.3

2.0

—

(36304419) Bacteria [Presence] in Urine

341

1.59

1.83

7.3

3.4

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

3.14

1.82

4.4

3.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

103

1.96

1.81

2.7

2.1

—

(3035350) Ketones [Presence] in Urine by Test strip

545

1.52

1.76

6.5

4.4

0.00

estimate

0.00

111

(3030905) Polymorphonuclear cells [#/volume] in Blood

3.42

1.76

2.3

1.6

4.59

5.04

e9/l

—

(3018095) Leukocytes [#/volume] in Urine

453

1.53

1.74

7.8

4.2

47.85

141.34

e6/l

1.48

349

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.20

1.71

2.0

2.6

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

3.24

1.68

4.3

4.9

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

3.24

1.68

2.3

1.7

61.50

58.32

—

(3022806) Fractional oxyhemoglobin in Capillary blood

3.24

1.68

3.7

1.8

86.18

89.45

—

(3023183) Ammonium ion [Moles/volume] in Plasma

2.88

1.67

1.9

1.7

24.29

27.49

umol/l

—

(3009261) Glucose [Presence] in Urine by Test strip

551

1.49

1.65

6.7

4.5

0.00

estimate

0.00

100

(3019198) Lymphocytes [#/volume] in Blood

561

1.49

1.64

10.4

5.6

1.65

1.81

e9/l

0.61

503

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

3.65

1.63

1.6

1.3

—

(4010399)

2.02

1.60

1.5

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

544

1.48

1.60

8.2

5.9

0.00

estimate

0.00

105

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.08

1.59

1.5

1.1

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

247

1.59

1.57

5.8

4.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

638

1.45

1.46

9.7

9.1

5.76

4.37

e9/l

2.27

553

(3002582) Erythrocytes [#/volume] in Urine

421

1.47

1.45

7.3

3.6

14.81

239.76

e6/l

0.87

335

(3020682) Albumin/Creatinine [Ratio] in Urine

403

1.48

1.45

6.1

4.1

48.31

9.53

mg/mmol

1.51

256

(3023419) Bacteria identified in Sputum by Culture

2.79

1.45

3.5

2.8

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.48

1.41

2.6

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.48

1.41

2.6

1.4

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.67

1.38

1.5

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

398

1.46

1.36

4.5

2.8

—

(3012516) Albumin [Mass/volume] in Urine

380

1.46

1.36

4.6

3.1

240.94

71.38

mg/l

1.00

246

(3019150) Specific gravity of Urine by Refractometry

248

1.53

1.33

6.9

5.1

1.02

kg/l

—

(3029937) Albumin [Presence] in Urine by Test strip

319

1.48

1.32

7.3

4.7

0.00

estimate

0.00

100

(42529406) Shigella sp [Presence] in Stool by Culture

2.42

1.31

1.0

1.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.42

1.31

1.0

1.3

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.83

1.29

1.4

1.3

—

(3022313) Gas panel - Capillary blood

1.94

1.28

2.5

2.9

—

(3021901) Oxygen saturation in Capillary blood

2.29

1.26

4.9

2.6

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

603

1.40

1.24

4.5

3.0

81.77

55.96

u/l

1.58

543

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.95

1.21

10.3

9.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.80

1.20

3.3

1.5

—

(3012441) Differential panel - Pleural fluid

2.55

1.16

1.2

1.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.05

1.14

1.0

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

214

1.50

1.11

6.3

5.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

163

1.56

1.10

1.6

1.4

3.12

3.08

g/l

0.02

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

2.42

1.10

1.6

1.8

—

(1616796) Gas panel - Central venous blood

2.24

1.09

9.7

3.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

433

1.38

1.07

7.2

4.9

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.11

1.04

1.0

1.3

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.97

1.04

2.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

1001

0.74

1.03

32.7

18.2

58.37

70.60

ml/min/173m2

4.40

831

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

142

1.55

0.98

25.3

9.8

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

354

0.68

0.98

3.0

3.2

0.88

ug/l

0.01

242

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

626

1.31

0.90

13.2

6.4

1.20

mmol/l

0.26

519

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.97

0.85

1.3

1.1

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

494

0.74

0.84

3.3

4.8

20.91

22.18

0.21

257

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.74

0.82

2.1

1.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

995

0.77

0.81

5.1

4.8

1.16

1.41

mmol/l

7.49

882

(4094501)

0.00

0.80

0.0

1.2

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.79

0.0

1.5

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.12

0.75

1.0

1.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.12

0.75

2.0

1.3

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.12

0.75

1.6

1.7

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

2.12

0.75

1.0

1.1

—

1.66

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

570

1.27

0.74

15.1

5.6

1.20

1.21

mmol/l

0.05

501

(3017181) Myelocytes/100 leukocytes in Blood

101

1.54

0.73

5.3

4.2

0.67

0.77

—

(40768804) Tissue Pathology biopsy report

443

0.76

0.73

2.5

2.2

—

(3021440) Promyelocytes/100 leukocytes in Blood

1.56

0.72

5.6

4.4

0.00

0.11

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

1046

0.79

0.71

5.9

5.5

2.19

2.47

mmol/l

2.53

928

(3019832) Treponema pallidum Ab [Presence] in Serum

1.95

0.71

1.4

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

968

0.79

0.71

4.6

4.4

2.47

2.09

mu/l

0.76

827

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.54

0.69

3.0

1.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.81

0.66

1.8

1.5

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

104

1115

0.80

0.62

47.5

22.5

122.00

88.23

umol/l

4.56

104

1115

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

1038

0.80

0.62

5.5

5.2

6.52

6.19

mmol/l

1.17

914

(3013707) Erythrocyte sedimentation rate by Westergren method

819

1.23

0.61

8.0

4.3

28.42

15.72

mm/h

4.67

738

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

617

0.81

0.58

4.5

5.5

3.68

3.22

ug/l

0.14

539

(46235355) HIV 1 and 2 tests - Meaningful Use set

107

1.44

0.58

4.5

1.5

—

(3025159) Blasts/100 leukocytes in Blood

1.48

0.57

6.0

4.3

0.00

0.24

—

(4034850)

1.65

0.56

26.8

15.8

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

1004

0.82

0.56

5.1

4.9

3.93

4.30

mmol/l

3.08

903

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.56

0.56

2.1

1.9

—

(3037756) Immunofixation for Serum or Plasma

1.56

0.53

1.8

1.6

—

(3021589) Normoblasts [#/volume] in Blood

481

1.22

0.53

20.4

11.0

0.00

0.01

e9/l

0.17

397

(3026008) Bacteria identified in Urine by Culture

414

1.23

0.53

4.8

3.6

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.52

0.52

1.3

1.8

—

(3022145) Colonoscopy Study observation

119

1.38

0.50

1.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

967

0.84

0.48

4.4

1.57

1.25

mmol/l

3.45

854

(3037467) Urinalysis macro (dipstick) panel - Urine

792

1.19

0.47

7.6

4.7

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

106

1121

0.83

0.46

16.1

11.3

23.85

24.20

u/l

0.09

100

1067

(1761868) Lipid panel - Serum or Plasma

291

0.79

0.43

3.1

3.7

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.41

0.0

1.1

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.41

0.0

1.4

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.4

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.40

0.0

1.2

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.4

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.4

—

(3044889) 12 lead EKG panel

790

0.86

0.39

6.8

4.6

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.39

0.0

1.3

—

15.79

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.39

0.0

1.4

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.39

0.0

1.2

—

1.79

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.39

0.0

1.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

877

0.86

0.37

43.0

20.6

35.16

38.34

0.84

535

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.45

0.36

8.0

2.5

2.93

1.77

mg/l

—

(3052851) Hemolysis interference index of Serum or Plasma

1.35

0.34

4.3

3.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.32

0.33

1.5

1.3

—

(40761511) CBC panel - Blood by Automated count

104

1089

0.87

0.33

37.1

18.1

—

(3000492) Spirometry study

1.35

0.33

2.4

1.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.33

0.33

1.3

1.4

—

(3002256) Pathology report gross observation

142

0.76

0.32

1.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.31

0.31

2.1

1.6

—

(1761482) Bacteria [#/volume] in Urine by Culture

1.29

0.30

3.4

5.5

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

1.29

0.30

2.4

1.7

1.31

0.39

g/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

140

1.24

0.29

6.6

4.1

—

(3049717) Cytology report of Urine Cyto stain

1.31

0.28

3.1

3.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

525

0.88

0.28

2.4

2.1

85.55

90.06

pmol/l

0.37

280

(3003694) ABO and Rh group [Type] in Blood

255

0.84

0.27

1.2

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

307

1.14

0.22

6.9

4.3

—

(3018418) pH of Serum or Plasma

375

1.13

0.22

11.6

3.9

7.40

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.23

0.22

1.4

1.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

1008

0.90

0.22

9.2

7.0

43.81

41.69

mmol/mol

0.99

915

(4035726)

1.24

0.22

1.3

—

(3002385) Erythrocyte distribution width [Ratio]

849

0.90

0.22

45.4

23.5

15.20

14.07

4.74

828

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.6

—

70.30

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

209.60

—

(4024509)

0.00

0.21

0.0

1.5

—

(3022621) pH of Urine by Test strip

1.27

0.21

5.8

3.0

—

(3014271) Vancomycin [Susceptibility]

0.00

0.21

0.0

2.5

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

757

0.91

0.20

3.6

3.5

14.75

15.06

pmol/l

0.44

643

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

1.23

0.20

2.5

1.7

1.37

0.00

g/l

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

105

1082

0.91

0.18

42.0

18.8

25.53

27.21

mg/l

0.31

100

906

(3000330) Specific gravity of Urine by Test strip

1.13

0.16

5.3

4.9

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.15

0.15

3.1

1.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

453

1.09

0.14

2.9

2.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

220

1.11

0.12

5.6

3.3

2.05

1.82

e6/l

0.07

137

(3013512) EKG study

378

1.08

0.11

5.3

4.8

—

(40761536) Microorganisms panel - Urine sediment

1.16

0.10

11.5

4.0

—

(3019225) pH of Specimen

125

1.13

0.10

5.2

4.0

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

1.11

0.10

2.8

1.7

0.00

g/l

—

(3000494) Fungus identified in Specimen by Culture

145

1.12

0.09

2.2

1.4

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.08

0.08

2.4

1.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.03

0.08

2.6

1.3

—

(3048689) Calprotectin [Mass/mass] in Stool

0.86

0.07

1.8

2.0

123.63

246.77

ug/g

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

218

1.06

0.05

4.3

3.0

0.54

0.90

e6/l

0.51

134

(3021960) Folate [Moles/volume] in Serum or Plasma

337

1.05

0.05

2.0

1.6

28.82

20.39

nmol/l

0.29

281

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

186

1.02

0.00

1.1

0.65

1.16

u/ml

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

14.26

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(4268621)

0.00

0.0

1.7

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.4

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.3

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.4

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(36660697) Celiac disease serology panel - Serum

0.92

0.00

1.0

1.1

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

22.72

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.7

—

16.43

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.7

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3004451) EKG impression Narrative

0.00

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

30.20

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.0

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

1.16

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.02

0.00

1.0

1.2

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.3

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.4

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.1

—

(3014891) Appearance of Pleural fluid

0.00

0.0

1.2

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.6

—

(3025941) Bacteria identified in Stool by Culture

1.00

0.00

1.0

1.4

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.4

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

10.38

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

5.2

—

237.11

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.3

—

3.65

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.6

—

(3017732) Neutrophils [#/volume] in Blood

0.88

0.00

4.8

3.0

4.71

3.51

e9/l

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(4027681)

0.00

0.0

1.2

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.1

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

1.97

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.4

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

0.0

1.0

—

19.60

—

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_GOUT and mortality.

Females

Parameter	HR [95% CI]	p-value
DRUGADVERS_GOUT	2.636 [2.17, 3.21]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.103

During the follow-up period (1.1.1998 — 31.12.2019), 583 out of 777 females with DRUGADVERS_GOUT died.

Males

Parameter	HR [95% CI]	p-value
DRUGADVERS_GOUT	2.856 [2.31, 3.53]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 683 out of 935 males with DRUGADVERS_GOUT died.

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_GOUT.

N-year risk	Females	Males
1	0.264%	0.645%
5	1.546%	3.143%
10	3.113%	7.409%
15	6.06%	14.055%
20	11.075%	22.563%

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_GOUT – Drug-induced gout

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced gout

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints