amyloidosis: A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
136 |
4. Check minimum number of eventsNone |
136 |
5. Include endpointsNone |
136 |
6. Filter based on genotype QC (FinnGen only) |
136 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E85
- Name in latin
- Amyloidosis in uno organo
Similar endpoints
↥List of similar endpoints to
Organ-limited amyloidosis
based on the number of shared cases.
Similar with more cases:
- Amyloidosis
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1581 | 719 | 850 |
| Only index persons | 1221 | 545 | 676 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 83.24 | 84.01 | 82.64 |
| Only index persons | 83.19 | 84.14 | 82.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 136 | 46 | 90 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 76.01 | 69.60 | 79.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 106
- Matched controls
- 1059
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E85.4
ICD-10 Finland
Organ-limited amyloidosis
+∞
152.9
106
*
E85.9
ICD-10 Finland
Amyloidosis, unspecified
+∞
36.6
33
*
I43.1*E85.9
ICD-10 Finland
Cardiac amyloidosis
+∞
12.8
12
*
E85.89
ICD-10 Finland
Other amyloidosis
+∞
11.7
11
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.0
10.7
39
110
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.5
8.5
63
315
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.2
8.1
22
43
I50.0
ICD-10 Finland
Congestive heart failure
4.7
7.5
26
68
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.0
7.4
24
58
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
42.9
6.9
8
*
I43.1
ICD-10 Finland
Cardiomyopathy in metabolic diseases
+∞
6.3
6
*
N08.4*E85.9
ICD-10 Finland
Glomerular disorders in amyloidosis
+∞
6.3
6
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.5
6.3
31
111
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma
35
23
20.14
41.49
5.5
2.5
mg/l
54.6
33.9
0.56
29
16
(3034860) Kappa light chains.free [Mass/volume] in Serum
35
23
20.14
41.49
5.5
2.5
mg/l
34.6
348.9
0.48
29
16
(40760888) Immunoglobulin light chains.free panel - Serum
30
17
22.36
37.95
5.8
2.6
—
—
—
0
0
(21494890) Protein electrophoresis panel - 24 hour Urine
20
10
23.28
26.28
2.5
1.3
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
37
68
7.10
20.63
3.7
1.7
—
—
—
0
0
(3037756) Immunofixation for Serum or Plasma
22
27
9.53
17.15
1.7
1.2
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
22
38
6.71
12.72
3.7
1.4
—
—
—
0
0
(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
22
38
6.71
12.72
3.7
1.4
g/l
7.1
7.5
0.67
17
30
(3047189) Immunofixation for 24 hour Urine
14
5
30.91
10.96
1.5
1.0
—
—
—
0
0
(3017817) Protein [Mass] in Urine collected for unspecified duration
10
10
10.71
8.75
2.0
1.5
—
—
—
0
0
(3012544) pH of Venous blood
28
88
3.75
7.92
4.5
3.2
—
—
—
0
0
(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma
22
61
4.11
7.38
7.7
2.7
ng/l
165.3
94.0
1.35
17
51
(3002032) Base excess in Venous blood by calculation
26
88
3.42
6.54
4.7
3.2
mmol/l
2.2
2.0
0.15
21
67
(3026493) Urate [Moles/volume] in Serum or Plasma
49
240
2.63
6.39
4.5
2.4
umol/l
412.8
4235.4
0.79
43
195
(4035726)
25
85
3.38
6.23
1.4
1.3
—
—
—
0
0
(3023520) Reticulocytes [#/volume] in Blood
26
93
3.22
5.97
2.2
2.7
e9/l
81.1
65.2
0.93
21
72
(3022313) Gas panel - Capillary blood
17
48
3.90
5.53
6.8
3.4
—
—
—
0
0
(3020876) Protein [Mass/time] in 24 hour Urine
8
5
16.86
5.48
2.4
1.6
—
—
—
0
0
(40768446) Kidney Pathology biopsy report
5
0
+∞
5.24
1.2
0.0
—
—
—
0
0
(3018677) aPTT in Platelet poor plasma by Coagulation assay
32
143
2.62
4.89
2.8
2.0
s
29.3
29.7
0.12
32
138
(3042111) Morphology [Interpretation] in Bone marrow Narrative
11
24
4.90
4.87
1.1
1.4
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
77
505
2.21
4.87
14.2
5.0
mmol/l
1.2
1.2
0.02
68
417
(3017766) Complement C4 [Mass/volume] in Serum or Plasma
10
20
5.32
4.86
1.8
1.1
g/l
0.2
0.2
—
10
20
(3007164) IgA [Mass/volume] in Serum or Plasma
32
144
2.60
4.82
2.4
1.4
g/l
2.7
3.2
0.28
26
80
(3023368) Bacteria identified in Blood by Culture
53
304
2.22
4.63
6.2
4.5
—
—
—
0
0
(3000620) Complement C3 [Mass/volume] in Serum or Plasma
10
21
5.06
4.61
1.8
1.2
g/l
1.2
1.1
—
10
21
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
68
432
2.15
4.58
6.3
3.9
ng/l
74.4
42.6
0.86
57
325
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
30
134
2.59
4.57
4.8
2.0
%
19.7
22.6
0.34
25
112
(3013115) Eosinophils [#/volume] in Blood
72
473
2.11
4.39
8.1
5.8
e9/l
0.2
0.2
0.41
65
409
(3006315) Basophils [#/volume] in Blood
70
458
2.09
4.28
8.1
5.6
e9/l
0.0
0.0
1.16
65
390
(3019309) Folate [Moles/volume] in Red Blood Cells
44
241
2.22
4.25
2.1
1.8
nmol/l
1017.1
1176.6
0.59
33
183
(3002030) Lymphocytes/100 leukocytes in Blood
68
442
2.08
4.22
8.2
5.7
%
21.9
26.1
2.06
62
403
(3001604) Monocytes [#/volume] in Blood
69
455
2.05
4.08
8.2
5.6
e9/l
0.6
0.6
0.00
63
386
(3019198) Lymphocytes [#/volume] in Blood
70
466
2.03
4.01
8.2
5.7
e9/l
1.5
1.7
1.67
65
406
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
58
362
2.05
3.96
6.6
3.2
ng/l
4443.4
1664.2
2.67
52
303
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
18
66
2.99
3.93
2.5
1.3
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
9
15
6.34
3.88
1.9
1.1
—
—
—
0
0
(3024561) Albumin [Mass/volume] in Serum or Plasma
65
427
2.00
3.81
8.3
3.4
g/l
32.7
34.4
1.15
60
388
(3032080) INR in Blood by Coagulation assay
65
429
1.99
3.75
12.8
10.4
inr
1.3
1.3
0.17
12
112
(3012441) Differential panel - Pleural fluid
9
16
5.94
3.72
1.0
1.4
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
15
51
3.18
3.71
6.7
4.7
mmol/l
25.5
25.3
0.07
15
51
(3000991) Gas panel - Venous blood
20
81
2.72
3.66
8.9
5.1
—
—
—
0
0
(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum
7
9
8.12
3.60
1.1
1.1
—
—
—
0
0
(3037121) Protein [Mass/volume] in Urine
12
36
3.56
3.57
2.6
3.1
g/l
0.4
0.2
—
6
9
(3023420) DNA double strand Ab [Units/volume] in Serum
6
6
10.38
3.53
2.0
1.2
—
—
—
0
0
(40768806) Pleura Pathology biopsy report
9
18
5.27
3.43
1.4
1.4
—
—
—
0
0
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
10
27
3.92
3.42
1.9
1.1
—
—
—
0
0
(3019225) pH of Specimen
22
99
2.46
3.27
7.5
3.4
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
17
67
2.76
3.27
2.6
1.4
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
10
28
3.78
3.26
1.6
1.1
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
23
106
2.41
3.25
3.2
1.5
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
13
45
3.09
3.12
1.7
2.8
—
—
—
0
0
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
42
253
1.96
3.04
2.6
2.2
mg/l
3.4
3.4
0.06
37
217
(3044640) Blood type and Crossmatch panel - Blood
48
303
1.90
3.03
2.7
2.6
—
—
—
0
0
(3044927) Protein electrophoresis panel - Urine
5
5
10.31
3.00
1.2
1.0
—
—
—
0
0
(3045142) Bone marrow Pathology biopsy report
7
13
5.61
2.91
1.1
1.2
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
73
531
1.81
2.90
10.8
9.2
e9/l
5.2
4.3
1.16
66
458
(40758558) Short blood count panel - Blood
37
217
1.97
2.88
6.5
6.5
—
—
—
0
0
(3009445) Proteinase 3 Ab [Units/volume] in Serum
10
32
3.29
2.70
1.4
1.7
—
—
—
0
0
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
7
15
4.86
2.63
2.1
2.7
%
228.9
183.9
—
7
15
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
9
220
0.37
2.61
2.3
1.6
mmol/l
1.1
1.2
—
9
166
(3018418) pH of Serum or Plasma
46
299
1.81
2.59
10.6
3.4
ph
7.4
7.4
—
9
63
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
31
177
1.97
2.59
1.7
1.8
—
—
—
0
0
(3035880) pH of Pleural fluid
5
7
7.36
2.57
1.0
1.1
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
17
76
2.41
2.56
2.8
1.4
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
51
345
1.77
2.51
4.1
2.5
ug/l
178.9
156.7
0.29
45
307
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
8
21
3.98
2.50
1.5
1.1
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
54
372
1.75
2.49
4.7
3.3
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
84
657
1.73
2.43
5.9
4.4
—
—
—
0
0
(3004616) Nuclear Ab [Presence] in Serum
5
8
6.43
2.39
1.0
1.1
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
12
47
2.70
2.34
1.9
1.2
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
47
316
1.74
2.34
6.8
5.3
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
10
36
2.92
2.25
1.6
1.5
—
—
—
0
0
(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability
5
10
5.14
2.09
1.2
1.0
—
—
—
0
0
(3021788) Differential panel - Synovial fluid
6
15
4.13
2.06
2.2
1.1
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
26
151
1.89
2.06
3.4
1.8
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
41
274
1.71
2.05
3.7
2.9
mg/l
1161.9
285.4
0.38
30
176
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
56
411
1.62
1.95
2.2
2.0
pmol/l
86.2
95.1
0.78
36
206
(3015377) Calcium [Moles/volume] in Serum or Plasma
48
339
1.64
1.94
4.6
2.7
mmol/l
2.4
2.4
0.30
43
290
(3052851) Hemolysis interference index of Serum or Plasma
9
34
2.76
1.90
3.9
3.1
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
35
230
1.70
1.85
2.2
2.4
—
—
—
0
0
(40768793) Breast Pathology biopsy report
5
13
3.95
1.73
1.0
1.3
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
42
295
1.61
1.71
3.2
3.6
mg/mmol
33.4
10.9
1.05
29
175
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
31
201
1.70
1.71
1.9
1.7
mg/l
1.7
1.6
0.15
20
158
(46235355) HIV 1 and 2 tests - Meaningful Use set
17
92
1.97
1.65
2.7
1.5
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
5
14
3.66
1.63
1.2
1.0
—
—
—
0
0
(3013290) Carbon dioxide [Partial pressure] in Blood
6
20
3.09
1.60
3.2
1.9
kpa
4.9
4.8
—
6
20
(3027315) Oxygen [Partial pressure] in Blood
6
20
3.09
1.60
3.2
1.9
kpa
8.4
8.1
—
6
20
(3009542) Hematocrit [Volume Fraction] of Blood
92
781
1.55
1.57
31.3
16.7
%
37.4
38.9
0.51
57
477
(40768804) Tissue Pathology biopsy report
49
364
1.54
1.56
2.6
2.3
—
—
—
0
0
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
6
22
2.80
1.45
1.0
1.4
—
—
—
0
0
(3021901) Oxygen saturation in Capillary blood
6
22
2.80
1.45
1.5
3.3
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
5
16
3.20
1.45
1.4
1.9
—
—
—
0
0
(3019060) Gas panel - Arterial blood
16
89
1.90
1.44
2.7
3.3
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
48
361
1.51
1.43
5.2
3.7
e6/l
107.0
115.4
0.05
36
266
(36304419) Bacteria [Presence] in Urine
38
272
1.55
1.41
4.8
3.1
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
7
29
2.49
1.41
1.6
1.2
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
9
41
2.28
1.40
1.1
1.7
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
6
23
2.68
1.38
1.3
1.2
—
—
—
0
0
(1616796) Gas panel - Central venous blood
5
17
3.01
1.37
1.8
3.1
—
—
—
0
0
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
31
213
1.59
1.37
2.4
2.8
mmol/l
2.5
2.5
0.66
26
186
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
56
439
1.47
1.35
4.7
4.2
—
—
—
0
0
(3022621) pH of Urine by Test strip
13
69
1.98
1.34
2.2
2.8
—
—
—
0
0
(3002582) Erythrocytes [#/volume] in Urine
43
320
1.50
1.33
4.8
3.3
e6/l
87.5
305.5
0.52
36
251
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
41
0.00
1.33
0.0
1.0
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
20
123
1.73
1.33
1.8
1.8
—
—
—
0
0
(3020891) Body temperature
10
48
2.17
1.31
3.0
3.3
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
18
280
0.59
1.28
3.3
2.9
—
—
—
0
0
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
64
520
1.44
1.26
3.5
2.8
u/l
51.7
52.1
0.02
59
475
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
6
26
2.37
1.20
1.5
1.3
—
—
—
0
0
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
6
26
2.37
1.20
1.5
1.3
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
103
919
1.50
1.20
33.0
15.9
mg/l
26.4
26.7
0.04
92
740
(3024928) Oxygen saturation in Venous blood
5
20
2.55
1.16
2.6
1.6
—
—
—
0
0
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
21
137
1.63
1.14
1.4
1.2
iu/ml
56.1
53.5
—
6
33
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
23
154
1.59
1.13
3.9
2.8
e6/l
2.5
1.8
0.12
14
87
(3028626) Oxygen [Partial pressure] in Capillary blood
7
31
2.32
1.12
1.4
2.8
kpa
9.0
7.9
—
7
24
(3000494) Fungus identified in Specimen by Culture
17
106
1.69
1.09
2.1
1.4
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
9
45
2.07
1.07
1.8
1.8
—
—
—
0
0
(3030467) Casts [#/volume] in Urine by Automated count
38
288
1.44
1.06
4.8
3.0
e6/l
0.9
0.4
0.62
32
217
(3014007) Fractional oxyhemoglobin in Arterial blood
12
68
1.84
1.04
9.3
5.4
%
94.2
93.1
0.35
12
68
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
9
51
1.82
0.96
10.8
6.4
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
6
27
2.28
0.94
5.7
1.4
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
9
52
1.78
0.94
1.0
1.1
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
11
63
1.81
0.93
1.3
1.4
—
—
—
0
0
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
31
232
1.44
0.92
1.6
1.8
pmol/l
511.1
432.7
0.64
26
190
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
18
122
1.55
0.85
1.8
1.8
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
40
321
1.35
0.80
3.9
3.2
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
56
473
1.31
0.79
4.2
4.1
estimate
0.0
0.0
0.00
15
86
(3000475) Leukocytes [#/volume] in Synovial fluid
5
23
2.22
0.77
3.2
1.1
e6/l
34550.0
12816.7
—
5
12
(3000850) Epithelial cells [#/volume] in Urine
30
231
1.38
0.77
4.0
2.7
e6/l
3.8
4.6
0.34
30
202
(3019550) Sodium [Moles/volume] in Serum or Plasma
105
970
1.36
0.76
37.9
18.0
mmol/l
139.1
139.7
1.39
99
933
(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
105
970
1.36
0.76
15.0
10.5
u/l
22.6
23.9
0.66
98
918
(3002256) Pathology report gross observation
18
126
1.49
0.75
1.2
1.4
—
—
—
0
0
(1002224) Polysomnography panel
5
27
1.88
0.69
1.0
1.1
—
—
—
0
0
(3023103) Potassium [Moles/volume] in Serum or Plasma
105
975
1.34
0.69
38.6
18.0
mmol/l
4.1
4.0
0.84
99
937
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
34
272
1.33
0.69
2.4
3.1
ug/l
0.6
0.8
0.83
26
187
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
18
129
1.46
0.67
1.4
1.3
u/ml
3.9
8.2
—
7
42
(3049717) Cytology report of Urine Cyto stain
8
50
1.64
0.62
1.5
3.3
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
5
30
1.69
0.62
1.0
1.2
—
—
—
0
0
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
22
167
1.38
0.62
3.9
2.7
e6/l
0.4
1.3
2.26
13
100
(3007461) Platelets [#/volume] in Blood
107
1002
1.32
0.61
44.8
22.9
e9/l
235.1
239.2
0.26
101
969
(3026361) Erythrocytes [#/volume] in Blood
107
1003
1.31
0.60
44.8
22.9
e12/l
4.2
4.4
2.64
99
959
(3010813) Leukocytes [#/volume] in Blood
107
1003
1.31
0.60
45.1
22.9
e9/l
7.0
6.7
0.82
99
958
(3015235) Bicarbonate [Moles/volume] in Capillary blood
6
35
1.75
0.58
2.0
2.6
mmol/l
23.9
25.3
—
6
26
(21494755) Public health laboratory ask at order entry panel
6
40
1.52
0.52
1.3
1.5
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
7
47
1.52
0.48
1.1
1.3
—
—
—
0
0
(3013512) EKG study
37
315
1.24
0.47
5.5
3.6
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
10
69
1.48
0.45
1.8
1.7
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
24
195
1.28
0.44
8.3
5.8
—
—
—
0
0
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
8
56
1.45
0.43
3.4
2.1
%
1.1
1.1
—
8
56
(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma
8
58
1.40
0.42
4.6
1.6
%
1.9
1.7
—
8
42
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma
17
134
1.31
0.39
2.8
4.4
%
32.7
31.5
0.18
12
83
(3011397) Hemoglobin [Presence] in Urine by Test strip
25
208
1.25
0.39
3.7
4.0
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
42
370
1.20
0.38
3.7
4.7
%
20.7
21.5
0.14
22
195
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
9
69
1.33
0.38
1.3
1.3
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
52
468
1.18
0.37
5.8
5.3
estimate
0.0
0.0
0.00
15
86
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
46
410
1.18
0.37
2.1
2.5
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
52
470
1.17
0.35
4.2
4.0
estimate
0.0
0.0
0.00
15
92
(3044889) 12 lead EKG panel
72
671
1.16
0.32
5.2
4.2
—
—
—
0
0
(3000492) Spirometry study
10
75
1.36
0.31
1.3
1.4
—
—
—
0
0
(40768443) Skin Pathology biopsy report
7
54
1.31
0.31
1.0
1.3
—
—
—
0
0
(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood
12
94
1.30
0.29
6.8
3.6
mmol/l
1.2
1.2
0.07
12
81
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
16
132
1.24
0.27
18.4
8.4
—
—
—
0
0
(3021589) Normoblasts [#/volume] in Blood
44
402
1.14
0.25
18.7
10.0
e9/l
0.0
0.0
0.50
37
320
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
94
905
1.13
0.22
4.7
5.1
mmol/l
2.5
2.6
1.27
82
790
(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(3045424) Erythrocytes [Presence] in Urine
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
(3035637) Corticotropin [Mass/volume] in Plasma
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting
0
12
0.00
0.21
0.0
1.1
—
0.7
—
0
12
(40761511) CBC panel - Blood by Automated count
99
957
1.13
0.21
32.8
14.6
—
—
—
0
0
(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
6
51
1.18
0.19
1.2
1.4
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
10
81
1.25
0.19
5.1
4.0
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
5
70
0.70
0.17
2.2
1.4
—
—
—
0
0
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
49
461
1.10
0.16
4.6
5.2
ug/l
4.0
5.6
0.26
41
397
(3021440) Promyelocytes/100 leukocytes in Blood
10
84
1.21
0.14
9.3
4.6
%
0.0
0.1
—
5
35
(40761535) Cells panel - Urine sediment
11
94
1.19
0.13
4.3
3.6
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
85
873
0.93
0.12
28.0
14.7
ml/min/173m2
67.1
73.2
1.18
69
714
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
92
898
1.08
0.11
4.8
5.0
mmol/l
5.8
6.0
1.09
82
783
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
88
858
1.07
0.11
5.4
6.1
mmol/mol
41.3
40.7
0.22
78
774
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
67
649
1.06
0.10
3.8
3.6
pmol/l
14.9
15.0
0.11
62
560
(3017181) Myelocytes/100 leukocytes in Blood
10
87
1.16
0.10
9.3
4.5
%
0.1
0.9
—
5
38
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
36
379
0.93
0.09
4.5
4.4
—
—
—
0
0
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
86
840
1.06
0.09
4.3
4.1
mmol/l
1.3
1.2
0.37
76
731
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
84
820
1.06
0.09
4.7
4.3
mu/l
2.2
2.1
0.48
74
707
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
7
65
1.08
0.08
2.6
2.5
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
9
84
1.08
0.07
1.1
1.4
—
—
—
0
0
(3019150) Specific gravity of Urine by Refractometry
20
211
0.94
0.05
4.0
4.5
kg/l
1.0
1.0
—
6
29
(3003694) ABO and Rh group [Type] in Blood
23
219
1.06
0.04
1.1
1.3
—
—
—
0
0
(3022145) Colonoscopy Study observation
10
109
0.91
0.04
1.2
1.3
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
86
869
0.97
0.02
4.7
4.5
mmol/l
1.4
1.5
1.25
77
762
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
11
104
1.06
0.01
5.6
3.8
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
26
266
0.97
0.00
4.8
3.9
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
13
129
1.01
0.00
1.6
1.2
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
28
276
1.02
0.00
4.6
4.4
estimate
0.0
0.0
0.00
11
84
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
88
877
1.01
0.00
4.7
4.6
mmol/l
4.2
4.5
2.25
80
781
(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3044936) Clostridioides difficile toxin A+B [Presence] in Stool by Immunoassay
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011544) Albumin [Mass/volume] in Pleural fluid
0
6
0.00
0.00
0.0
1.0
—
17.9
—
0
6
(3048689) Calprotectin [Mass/mass] in Stool
8
81
0.99
0.00
2.9
2.6
ug/g
266.5
151.7
—
8
70
(4024509)
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3024474) Albumin [Mass/volume] in Cerebral spinal fluid
0
6
0.00
0.00
0.0
1.2
—
215.3
—
0
6
(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3044242) Glucose [Moles/volume] in Arterial blood
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3006442) Creatine [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3032773) Endomysium IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
(3017569) Oxygen content in Arterial blood
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
(4010399)
7
69
1.02
0.00
1.1
1.3
—
—
—
0
0
(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3000012) Reticulocyte production index
0
9
0.00
0.00
0.0
2.9
—
—
—
0
0
(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(44806420)
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(40768441) Liver Pathology biopsy report
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(4027681)
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3051593) INR in Capillary blood by Coagulation assay
0
5
0.00
0.00
0.0
20.2
—
—
—
0
0
(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
30.8
—
0
5
(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3011985) Renin [Units/volume] in Plasma
0
5
0.00
0.00
0.0
1.2
—
28.2
—
0
5
(3011363) Streptococcus pneumoniae Ag [Presence] in Urine
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_AMYL_ORGAN and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_AMYL_ORGAN.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_AMYL_ORGAN – Organ-limited amyloidosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data