No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
113 |
4. Check minimum number of eventsNone |
113 |
5. Include endpointsNone |
113 |
6. Filter based on genotype QC (FinnGen only) |
110 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E87
- Name in latin
- Incrementum voluminis liquoris
Similar endpoints
↥List of similar endpoints to
Fluid overload
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 582 | 293 | 287 |
| Only index persons | 524 | 263 | 261 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 69.82 | 72.88 | 66.78 |
| Only index persons | 69.84 | 72.88 | 66.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 110 | 53 | 57 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 65.63 | 68.61 | 62.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 113
- Matched controls
- 1130
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E87.7
ICD-10 Finland
Fluid overload
+∞
163.0
113
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
40.3
78.5
55
26
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
197.9
48.1
47
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
228.2
44.4
43
*
C03CA01
ATC
furosemide; systemic
16.5
43.4
91
227
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
113.8
41.5
43
6
TK800
NOMESCO Finland
Hemodialysis
78.5
40.3
44
9
I50.9
ICD-10 Finland
Heart failure, unspecified
11.1
37.1
57
95
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
11.7
37.0
51
74
N18.8
ICD-10 Finland
Other chronic renal failure
97.7
36.8
39
6
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
14.8
33.0
34
32
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
114.9
31.7
33
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
210.9
31.4
31
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
9.3
30.6
52
95
B03XA02
ATC
darbepoetin alfa; parenteral
140.8
30.4
31
*
A10AE04
ATC
insulin glargine; parenteral
10.3
27.2
37
51
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
333.8
26.9
26
*
XF600
NOMESCO Finland
Bloodpressure measurement
13.5
26.4
28
27
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
10.6
26.2
34
44
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
7.9
25.9
50
103
A12AA04
ATC
calcium carbonate; oral
73.5
25.4
28
5
A10AC01
ATC
insulin (human); parenteral
11.2
25.3
31
37
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
9.2
25.3
38
59
SPAT1262
SPAT
Handing over of treatment supplies
7.6
25.2
51
110
215
Kela drug reimbursment
Diabetes, non-insulin-treated
7.1
24.5
58
146
GD1AA
NOMESCO Finland
Thorax X-ray examination
9.6
24.3
93
368
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
7.0
24.3
63
173
A11CC03
ATC
alfacalcidol; systemic
79.3
22.9
25
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
270.2
22.5
22
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
23.0
22.1
32
19
A10AB05
ATC
insulin aspart; parenteral
9.3
22.0
31
44
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
75.2
21.9
24
*
127
Kela drug reimbursment
Transplant complication
135.2
21.4
22
*
103
Kela drug reimbursment
Diabetes, insulin-treated
6.2
21.3
60
174
N17.9
ICD-10 Finland
Acute renal failure, unspecified
34.9
21.2
27
10
M04AA01
ATC
allopurinol; systemic
6.9
20.7
42
89
A46
ICD-10 Finland
Erysipelas
7.0
20.7
41
85
L04AA06
ATC
mycophenolic acid; systemic
90.0
20.5
22
*
E87.5
ICD-10 Finland
Hyperkalaemia
+∞
20.4
19
*
L04AD02
ATC
tacrolimus; systemic
+∞
20.4
19
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
7.1
20.3
39
78
N18.0
ICD-10 Finland
End-stage renal disease
240.4
20.2
20
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
67.5
19.7
22
*
JN3AD
NOMESCO Finland
Abdominal CT examination
7.5
19.6
34
61
V03AE01
ATC
polystyrene sulfonate; oral
120.3
19.2
20
*
Z94.0
ICD-10 Finland
Kidney transplant status
120.3
19.2
20
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
7.7
19.1
32
55
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
7.7
19.1
32
55
SPAT1148
SPAT
Treatment of chronic ulcer or burn
6.4
19.0
42
96
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
8.3
18.4
28
43
TPX10
NOMESCO Finland
Implantation of vascular injection port
23.7
18.4
26
14
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
35.6
18.3
23
8
V03AE02
ATC
sevelamer; oral
+∞
18.2
17
*
ZXD05
NOMESCO Finland
Urgent procedure
5.4
17.9
59
191
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
9.3
17.7
24
32
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.3
17.3
58
189
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
9.0
17.3
24
33
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
106.1
17.1
18
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
5.3
17.0
50
146
137
Kela drug reimbursment
Uraemia requiring dialysis
198.0
17.0
17
*
D64.9
ICD-10 Finland
Anaemia, unspecified
6.7
17.0
33
66
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
7.9
16.6
26
41
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
56.5
16.6
19
*
N19
ICD-10 Finland
Unspecified kidney failure
21.8
16.0
23
13
TPH07
NOMESCO Finland
Cathetrisation of artery
6.4
15.9
32
66
M10.9
ICD-10 Finland
Gout, unspecified
14.4
15.8
27
24
R50.9
ICD-10 Finland
Fever, unspecified
5.5
15.8
40
102
WX204
NOMESCO Finland
Axillary plexus blockaced
20.2
15.6
23
14
WX408
NOMESCO Finland
General anesthesy, balanced
4.9
15.6
52
167
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
7.2
15.2
26
45
C07AB07
ATC
bisoprolol; oral
5.3
15.2
83
387
I50.0
ICD-10 Finland
Congestive heart failure
7.4
15.1
25
42
S97
ICPC
Chronic ulcer skin
7.4
15.1
25
42
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
92.4
15.0
16
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
14.9
14
*
Z49.2
ICD-10 Finland
Other dialysis
+∞
14.9
14
*
205
Kela drug reimbursment
Chronic hypertension
4.6
14.5
54
187
C08CA01
ATC
amlodipine; oral
4.6
14.3
70
297
C08CA02
ATC
felodipine; oral
7.2
14.2
24
41
R06.0
ICD-10 Finland
Dyspnoea
4.5
13.9
55
198
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
13.5
13.8
24
22
196
Kela drug reimbursment
Paricalcitol and cinacalcet
158.2
13.8
14
*
T90
ICPC
Diabetes non-insulin dependent
4.6
13.6
46
147
J01FF01
ATC
clindamycin; systemic
4.3
13.1
51
180
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.2
13.0
64
268
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
36.8
13.0
16
5
H05BX01
ATC
cinacalcet; oral
79.0
12.9
14
*
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
17.0
12.9
20
14
AA1AD
NOMESCO Finland
CT of head and brain
4.2
12.8
52
189
ZXE00
NOMESCO Finland
One hour or less
4.2
12.8
65
277
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.2
12.8
54
202
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
12.7
12
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
+∞
12.7
12
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
+∞
12.7
12
*
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
145.5
12.7
13
*
B05DA
ATC
Isotonic solutions
145.5
12.7
13
*
ZXE10
NOMESCO Finland
More than one and less than three hours
4.1
12.6
60
244
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
13.3
12.2
21
19
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
13.3
12.2
21
19
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
4.2
11.9
44
148
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
72.7
11.9
13
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
4.6
11.7
35
100
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
133.0
11.7
12
*
B05DB
ATC
Hypertonic solutions
+∞
11.7
11
*
KBV00
NOMESCO Finland
Insertion of stent into ureter
+∞
11.7
11
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
10.6
11.4
22
25
J01MA12
ATC
levofloxacin; systemic
4.1
11.4
42
141
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.9
11.3
30
78
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
17.9
11.2
17
11
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
10.2
11.2
22
26
H02AB06
ATC
prednisolone; systemic
3.9
11.2
73
360
B01AA03
ATC
warfarin; systemic
4.3
11.1
38
120
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
31.6
11.0
14
5
I25.1
ICD-10 Finland
Atherosclerotic heart disease
4.1
11.0
41
138
A10BA02
ATC
metformin; oral
3.9
11.0
48
181
X59
ICD-10 Finland
Exposure to unspecified factor
4.3
10.9
37
116
H02AB04
ATC
methylprednisolone; systemic
4.6
10.9
32
90
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
66.4
10.8
12
*
J01MA14
ATC
moxifloxacin; systemic
5.3
10.7
25
58
JN4AD
NOMESCO Finland
Body CT examination
5.3
10.7
25
58
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
+∞
10.6
10
*
AN1
HP
Coronary angiography
5.5
10.6
23
50
WZC00
NOMESCO Finland
Treatment plan or consultation
3.6
10.5
59
261
SPAT1222
SPAT
Counselling/guidance promoting independent living
4.2
10.4
35
109
C03DA01
ATC
spironolactone; oral
4.7
10.2
28
74
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.3
10.1
23
52
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
15.3
10.0
16
12
N02AA05
ATC
oxycodone; systemic
4.0
10.0
37
123
B01AB10
ATC
tinzaparin; parenteral
4.8
10.0
26
66
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
4.0
9.9
36
118
WX730
NOMESCO Finland
Conventional respirator
60.3
9.8
11
*
EBA10
NOMESCO Finland
Operative extraction of tooth
5.0
9.7
24
58
A10AA02, ,
ATC
14.1
9.7
16
13
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
12.3
9.7
17
16
H04AA01
ATC
glucagon; nasal, parenteral
24.2
9.6
13
6
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
8.3
9.6
21
30
E86
ICD-10 Finland
Volume depletion
108.8
9.6
10
*
V03AE03
ATC
lanthanum carbonate; oral
108.8
9.6
10
*
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
+∞
9.5
9
*
OAB70
NOMESCO Finland
Guidance related to hydration
+∞
9.5
9
*
3025
Kela drug reimbursment
Calcium carbonate
+∞
9.5
9
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
5.8
9.5
19
38
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
4.3
9.4
29
84
ZXE20
NOMESCO Finland
More than three and less than five hours
4.3
9.4
29
84
WX892
NOMESCO Finland
Monitored bed care
8.1
9.4
21
31
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
5.3
9.3
21
47
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.0
9.2
32
101
A10BH01
ATC
sitagliptin; oral
4.9
9.2
23
56
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
10.0
9.2
18
21
A10AB01
ATC
insulin (human); parenteral
10.9
9.2
17
18
R4110
NOMESCO Finland
Physiotherapy
3.5
9.1
46
187
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.6
9.0
40
150
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
54.3
8.8
10
*
ED1AA
NOMESCO Finland
Mandibular X-ray examination
54.3
8.8
10
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
18.1
8.8
13
8
A10BH05
ATC
linagliptin; oral
9.1
8.8
18
23
C07AB02
ATC
metoprolol; systemic
3.6
8.7
38
140
A41.9
ICD-10 Finland
Sepsis, unspecified
10.8
8.6
16
17
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
10.8
8.6
16
17
WX402
NOMESCO Finland
General anaesthesia
3.7
8.5
33
112
PB1AC
NOMESCO Finland
Angiography of upper extremity with X-ray
97.0
8.5
9
*
A10AE05
ATC
insulin detemir; parenteral
7.9
8.5
19
28
T89
ICPC
Diabetes insulin dependent
9.3
8.5
17
21
A10AA01, ,
ATC
16.1
8.4
13
9
H3603, E103,
ICD-10 Finland
+∞
8.4
8
*
WX213
NOMESCO Finland
Lower leg blockade
+∞
8.4
8
*
QXA20
NOMESCO Finland
Skin abrasion, unspecified location
+∞
8.4
8
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
10.1
8.4
16
18
C02AC05
ATC
moxonidine; oral
13.1
8.3
14
12
E0000UV, ,
ATC
3.1
8.3
58
284
A10AD01
ATC
insulin (human); parenteral
24.1
8.2
11
5
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.8
8.2
30
98
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
3.8
8.2
30
98
SPAT1149
SPAT
Suture or treatment of traumatic wound
3.8
8.1
29
93
GD1AD
NOMESCO Finland
Thorax CT examination
7.7
8.0
18
27
KA1AE
NOMESCO Finland
Kidney ultrasound examination
16.6
7.9
12
8
321
Kela drug reimbursment
Paricalcitol and cinacalcet
48.5
7.8
9
*
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
20.1
7.8
11
6
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
27.2
7.7
10
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
27.2
7.7
10
*
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
27.2
7.7
10
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.8
7.7
28
91
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
85.5
7.5
8
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
85.5
7.5
8
*
PG1XE
NOMESCO Finland
Other ultrasound examination of blood vessel not elsewhere classified
85.5
7.5
8
*
C10AA01
ATC
simvastatin; oral
3.0
7.5
58
296
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.2
7.5
22
61
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.8
7.4
26
82
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.9
7.4
58
298
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
+∞
7.4
7
*
SPAT1254
SPAT
Administration of medicine
3.6
7.3
28
94
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.0
7.2
17
39
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.6
7.2
19
48
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
8.5
7.2
15
20
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
6.5
7.1
18
32
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
7.6
7.1
16
24
I50.1
ICD-10 Finland
Left ventricular failure
6.9
7.1
17
28
C01DA14
ATC
isosorbide mononitrate; oral
3.8
7.1
25
79
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
9.2
7.1
14
17
A02BC02
ATC
pantoprazole; systemic
3.5
7.1
90
598
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.0
7.0
41
178
L28
ICPC
Limited function/disability (L)
3.4
7.0
31
114
C10AA05
ATC
atorvastatin; oral
2.9
7.0
60
321
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
6.7
6.9
17
29
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
18.1
6.9
10
6
B01AF02
ATC
apixaban; oral
3.9
6.9
23
70
B03XA01
ATC
erythropoietin; parenteral
42.7
6.8
8
*
M10.3
ICD-10 Finland
Gout due to impairment of renal function
42.7
6.8
8
*
E87.6
ICD-10 Finland
Hypokalaemia
24.2
6.8
9
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.8
6.7
50
247
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.2
6.7
32
123
UJF32
NOMESCO Finland
Coloscopy
2.9
6.6
42
190
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
6.7
6.6
16
27
C09AA02
ATC
enalapril; systemic
3.1
6.6
34
137
E000002, ,
ATC
4.4
6.6
18
47
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
3.0
6.5
37
157
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
15.5
6.5
10
7
GD2SN
NOMESCO Finland
Lung ventilation SPECT
73.8
6.5
7
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
73.8
6.5
7
*
EE1AA
NOMESCO Finland
X-ray of upper jaw or palate
73.8
6.5
7
*
R80
ICD-10 Finland
Isolated proteinuria
73.8
6.5
7
*
R03BA02
ATC
budesonide; inhalant
3.3
6.5
30
113
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
4.5
6.4
17
43
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
6.5
6.4
16
28
R60.9
ICD-10 Finland
Oedema, unspecified
6.5
6.4
16
28
207
Kela drug reimbursment
Chronic arrhythmias
3.4
6.4
27
96
XCK10
NOMESCO Finland
Photography of fundus of eye
4.1
6.4
19
53
N17.8
ICD-10 Finland
Other acute renal failure
28.4
6.3
8
*
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
3.6
6.3
23
74
ZPB96
NOMESCO Finland
Other material in vessel transplant
+∞
6.3
6
*
SPAT1094
SPAT
Continuous Positive Airway Pressure
+∞
6.3
6
*
TK823
NOMESCO Finland
Peritoneal permeability analysis
+∞
6.3
6
*
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
+∞
6.3
6
*
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
+∞
6.3
6
*
G47.3
ICD-10 Finland
Sleep apnoea
3.0
6.3
37
160
OAB43, ,
SPAT
0.0
6.2
*
174
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
6.2
34
141
E66.00
ICD-10 Finland
Metabolic syndrome
6.0
6.1
16
30
Z3231
NOMESCO Finland
Registered nurse
2.8
6.1
40
183
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.7
6.1
46
227
A06AD11
ATC
lactulose; oral
3.3
6.1
26
93
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
16.1
6.0
9
6
R4180
NOMESCO Finland
Podiatric therapy
16.1
6.0
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
40
18
33.85
56.97
7.1
2.0
14.67
15.73
%
—
27
10
47
39
19.92
50.39
18.2
5.6
23.54
25.27
mmol/l
1.70
47
39
71
116
14.78
48.61
11.0
2.0
20.11
24.11
%
1.39
66
102
36
22
23.55
44.67
5.8
3.0
23.63
24.20
mmol/l
0.19
36
22
34
21
22.73
41.84
5.6
3.3
8.21
8.02
kpa
0.17
34
21
58
87
12.64
41.53
10.0
3.4
—
—
—
0
0
47
53
14.47
41.22
9.4
2.8
2.31
1.72
mmol/l
0.38
35
43
35
31
15.91
35.35
1.6
3.7
1.86
1.39
g/l
1.07
30
26
36
35
14.63
34.30
8.8
4.2
23.82
24.54
mmol/l
0.47
36
35
62
138
8.74
30.55
4.2
1.9
—
—
—
0
0
38
14
40.07
30.52
15.0
1.9
4.98
4.92
kpa
0.12
38
14
34
13
36.70
26.84
4.8
1.7
1.31
1.58
mmol/l
0.72
34
13
29
29
13.11
26.77
2.9
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
33
13
35.18
25.81
3.9
2.4
0.31
0.23
u/ml
—
21
8
69
202
7.20
24.98
3.8
1.9
3.33
3.05
mg/l
0.51
61
175
37
62
8.39
22.91
3.3
1.6
—
—
—
0
0
97
417
10.37
22.69
44.5
6.5
1.18
1.21
mmol/l
3.60
74
354
77
272
6.75
22.08
5.5
3.0
10299.94
1311.82
ng/l
3.54
69
232
73
253
6.33
21.16
11.6
2.7
0.67
0.46
e6/l
0.42
64
186
94
415
8.52
20.58
47.2
12.6
1.33
1.24
inr
0.56
49
116
83
335
6.57
19.83
12.8
3.4
76.14
36.09
ng/l
1.45
76
244
44
105
6.22
19.04
3.5
1.7
—
—
—
0
0
81
328
6.19
19.03
13.4
2.9
—
—
—
0
0
43
102
6.19
18.69
3.6
1.7
—
—
—
0
0
30
50
7.81
18.40
1.9
1.5
—
—
—
0
0
26
16
20.68
17.59
2.2
1.2
270.08
233.50
u/ml
—
20
8
68
250
5.32
17.58
12.6
3.3
64.19
5.96
mg/mmol
2.86
62
147
74
294
5.40
17.31
6.9
2.7
62.30
55.71
u/l
0.41
67
266
26
17
19.45
17.22
2.0
1.2
—
—
—
0
0
25
17
18.49
16.30
2.6
1.1
—
—
—
0
0
28
26
13.92
16.14
2.8
1.5
—
—
—
0
0
20
8
29.93
15.31
3.3
1.3
—
—
—
0
0
51
164
4.85
15.17
3.0
1.7
1819.70
1211.43
nmol/l
1.38
37
120
98
526
7.50
15.07
21.4
5.0
7.64
6.61
mmol/l
3.48
93
487
20
10
23.93
14.39
3.3
1.2
—
—
—
0
0
54
188
4.59
14.38
2.4
1.5
1.22
1.43
mg/l
0.37
47
146
23
18
15.71
14.18
3.0
1.6
—
—
—
0
0
26
27
12.15
14.17
2.8
1.4
—
—
—
0
0
21
15
16.87
13.40
3.2
1.1
—
—
—
0
0
21
15
16.87
13.40
4.8
4.9
63.62
58.13
%
0.54
21
15
24
44
6.66
13.24
8.2
3.2
122.63
128.70
g/l
0.50
24
44
20
14
17.05
12.85
4.7
4.0
4.89
4.17
e9/l
0.45
20
14
15
5
34.19
11.98
2.5
1.4
—
—
—
0
0
16
7
26.31
11.95
1.4
1.3
—
—
—
0
0
83
437
4.39
11.73
9.3
3.2
0.00
0.00
estimate
-0.00
37
88
11
0
+∞
11.65
6.7
0.0
48.18
—
ug/min
—
11
0
82
432
4.27
11.49
10.8
4.2
0.00
0.00
estimate
-0.00
42
89
82
436
4.21
11.24
9.4
3.2
0.00
0.00
estimate
-0.00
42
95
59
252
3.81
11.24
9.9
3.6
0.00
0.00
estimate
-0.00
22
87
33
93
4.60
11.22
9.8
12.1
2.36
1.34
mmol/l
0.33
21
75
77
395
3.98
11.07
4.0
2.7
—
—
—
0
0
35
105
4.38
10.97
9.3
5.7
101.46
103.79
mmol/l
1.25
35
105
17
13
15.14
10.56
2.4
1.5
—
—
—
0
0
14
6
26.33
10.53
1.5
1.3
101.71
30.83
u/l
—
14
6
67
324
3.62
10.32
2.4
1.9
107.07
99.37
pmol/l
0.42
36
163
46
177
3.70
10.06
3.7
2.5
—
—
—
0
0
25
61
4.98
10.05
4.1
2.4
34.50
70.55
ml/min/173m2
3.64
18
22
19
37
5.97
9.75
5.9
2.2
1.61
1.28
%
0.46
19
37
19
37
5.97
9.75
5.8
2.2
0.65
0.66
%
0.03
19
37
69
350
3.49
9.66
9.6
3.4
—
—
—
0
0
13
6
24.22
9.59
1.1
1.2
—
—
—
0
0
9
0
+∞
9.50
10.2
0.0
—
—
—
0
0
17
17
11.54
9.41
2.4
1.4
—
—
—
0
0
17
20
9.79
8.68
2.4
1.3
—
—
—
0
0
17
21
9.32
8.45
2.1
2.0
97.71
85.29
%
0.98
17
21
8
0
+∞
8.43
3.3
0.0
—
—
—
0
0
15
15
11.33
8.32
2.5
1.3
—
—
—
0
0
15
15
11.33
8.32
1.4
1.5
—
—
—
0
0
59
292
3.14
8.25
4.0
3.5
27.83
31.48
u/l
0.69
54
273
18
28
7.43
7.80
2.3
3.3
—
—
—
0
0
17
25
7.80
7.64
1.3
1.8
—
—
—
0
0
11
7
17.21
7.39
1.5
1.9
—
—
—
0
0
7
0
+∞
7.36
4.1
0.0
403.71
—
umol/l
—
7
0
89
596
3.32
6.71
6.0
3.0
73.12
52.10
u/l
1.03
84
554
16
28
6.47
6.43
2.4
1.1
—
—
—
0
0
13
18
8.00
6.12
2.4
2.7
230.62
204.50
%
0.24
13
18
5
0
+∞
5.24
1.2
0.0
—
—
—
0
0
5
0
+∞
5.24
5.0
0.0
—
—
—
0
0
8
6
14.20
5.16
3.2
2.5
—
—
—
0
0
9
9
10.73
5.12
1.2
1.0
—
—
—
0
0
11
16
7.48
5.09
1.5
1.3
—
—
—
0
0
31
136
2.76
5.03
4.5
2.6
3.54
2.05
e6/l
0.28
17
72
33
151
2.67
4.93
4.4
2.3
0.62
1.02
e6/l
0.66
19
87
19
64
3.37
4.83
5.4
3.7
193.92
220.82
ng/l
0.14
19
59
11
20
5.97
4.41
1.5
1.6
—
—
—
0
0
11
21
5.68
4.26
1.5
1.8
9.85
11.04
mg/l
0.14
11
21
88
654
2.56
4.26
5.4
3.7
15.08
14.91
pmol/l
0.20
82
586
11
22
5.42
4.12
2.5
1.2
—
—
—
0
0
11
22
5.42
4.12
2.5
1.2
—
—
—
0
0
6
5
12.56
3.80
7.5
7.8
613.00
662.80
nmol/l
—
6
5
6
5
12.56
3.80
10.2
9.8
1319.83
1084.00
nmol/l
—
6
5
13
35
4.06
3.74
18.4
3.0
24.98
24.80
mmol/l
0.06
13
35
11
26
4.57
3.61
4.0
2.7
—
—
—
0
0
35
191
2.21
3.45
1.5
1.2
8.51
1.00
u/ml
0.44
12
43
9
18
5.33
3.45
1.4
1.6
—
—
—
0
0
9
18
5.33
3.45
1.4
1.6
—
—
—
0
0
10
24
4.46
3.28
3.8
2.4
—
—
—
0
0
0
84
0.00
3.28
0.0
1.8
—
—
—
0
0
12
36
3.60
3.13
1.9
1.9
—
—
—
0
0
6
8
7.84
3.09
1.5
1.3
93.17
160.50
u/l
—
6
8
5
5
10.37
3.00
1.6
2.6
—
—
—
0
0
5
5
10.37
3.00
1.6
2.6
—
—
—
0
0
100
841
2.64
2.88
79.1
12.9
48.19
80.01
ml/min/173m2
12.39
95
705
5
6
8.64
2.77
4.0
1.3
—
—
—
0
0
5
6
8.64
2.77
4.0
1.3
—
—
—
0
0
6
10
6.26
2.73
1.5
1.4
—
—
—
0
0
8
21
4.02
2.51
3.5
1.3
—
—
—
0
0
12
46
2.80
2.45
3.6
1.7
—
—
—
0
0
5
9
5.75
2.23
1.2
1.3
—
—
—
0
0
5
10
5.17
2.09
1.2
1.1
—
—
nmol/l
—
0
0
28
168
1.89
2.06
3.5
2.6
2.48
2.46
mmol/l
0.36
23
148
8
27
3.11
1.98
1.4
1.2
—
—
—
0
0
5
11
4.70
1.96
1.6
1.7
—
—
—
0
0
5
11
4.70
1.96
1.6
1.7
—
—
—
0
0
5
11
4.70
1.96
1.6
1.7
—
—
—
0
0
68
538
1.66
1.84
4.5
2.7
—
—
—
0
0
5
12
4.30
1.84
3.4
1.3
—
—
—
0
0
5
12
4.30
1.84
3.4
1.3
—
—
—
0
0
5
12
4.30
1.84
3.4
1.3
—
—
—
0
0
5
12
4.30
1.84
3.4
1.3
—
—
—
0
0
5
12
4.30
1.84
4.6
2.3
105.00
106.08
mmol/l
—
5
12
5
12
4.30
1.84
3.4
1.3
—
—
—
0
0
6
18
3.46
1.77
1.3
1.1
—
—
—
0
0
5
13
3.97
1.73
3.4
1.3
—
—
—
0
0
16
273
0.52
1.65
3.7
4.4
24.97
19.85
%
—
6
126
6
20
3.11
1.60
2.2
1.2
—
—
—
0
0
9
38
2.48
1.49
3.7
1.3
—
—
—
0
0
14
74
2.02
1.46
3.6
2.0
35.46
5.22
ug/l
0.45
14
68
5
16
3.22
1.45
1.0
1.2
—
—
—
0
0
22
140
1.71
1.33
1.2
1.3
35.33
22.46
iu/ml
—
6
47
5
18
2.86
1.30
1.0
1.1
—
—
—
0
0
6
26
2.38
1.20
1.2
1.6
—
227.45
miu/ml
—
0
11
16
97
1.76
1.14
1.9
4.2
3.93
118.66
ug/l
0.84
11
84
5
22
2.33
1.04
1.0
1.9
—
11275.80
—
0
5
6
113
0.50
0.89
1.3
1.3
—
—
—
0
0
19
132
1.53
0.83
1.2
1.3
26.40
15.17
u/ml
—
7
51
7
38
1.90
0.75
1.3
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
2.37
—
0
9
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
203.09
—
0
10
0
10
0.00
0.21
0.0
3.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
9
79
1.15
0.16
1.7
2.4
—
—
—
0
0
7
88
0.78
0.15
4.4
2.4
16.80
14.22
nmol/l
—
7
80
10
87
1.16
0.10
1.7
2.4
—
—
—
0
0
88
866
1.07
0.07
8.2
4.4
6.85
5.93
mmol/l
3.19
81
775
13
128
1.02
0.00
1.5
1.6
—
—
—
0
0
11
111
0.99
0.00
19.5
6.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
106.83
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
0.29
—
0
6
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_FLUIDOVER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDOVER | 3.281 [1.98, 5.44] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.135 |
During the follow-up period (1.1.1998 — 31.12.2019), 103 out of 212 females with E4_FLUIDOVER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDOVER | 6.861 [3.77, 12.48] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.098 |
During the follow-up period (1.1.1998 — 31.12.2019), 127 out of 212 males with E4_FLUIDOVER died.
Mortality risk
Mortality risk for people of age
years, who have E4_FLUIDOVER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.229% | 1.763% |
| 5 | 1.508% | 9.368% |
| 10 | 4.476% | 22.161% |
| 15 | 8.006% | 39.888% |
| 20 | 13.834% | 56.64% |
Relationships between endpoints
↥Index endpoint: E4_FLUIDOVER – Fluid overload
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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