Toxic encephalopathy

G6_ENCEPHTOX

toxic encephalopathy: A group of neurologic disorders caused by damage to the nervous system following exposure to pharmacologic, biologic, and chemical agents. Examples of neurotoxins include chemotherapy agents, radiation treatment, heavy metals, pesticides, and food additives.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G92 Hospital discharge: ICD-9 — 3498B Hospital discharge: ICD-8 — 32302 Cause of death: ICD-10 — G92 Cause of death: ICD-9 — 3498B Cause of death: ICD-8 — 32302 2 out of 7 registries used, show all original rules.	73
4. Check minimum number of events None	73
5. Include endpoints None	73
6. Filter based on genotype QC (FinnGen only)	73

Control definitions (FinnGen only)

Control exclude: G6_OTHNEU

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G90-G99
Name in latin: Encephalopathia toxica

NAME	G6_ENCEPHTOX
CONTROL_EXCLUDE	G6_OTHNEU
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G92
HD_ICD_9	3498B
HD_ICD_8	32302
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G92
COD_ICD_9	3498B
COD_ICD_8	32302
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Toxic encephalopathy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	830	208	606
Only index persons	579	148	431
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.02
Only index persons	0.01	0.01	0.02
Median age at first event (years)
Whole population	54.80	56.22	54.21
Only index persons	54.43	55.16	54.19

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	73	16	57
Unadjusted period prevalence (%)	0.02	0.01	0.03
Median age at first event (years)	55.47	55.12	55.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
71: Matched controls
711

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G92

ICD-10 Finland

Toxic encephalopathy

+∞

80.0

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

10.7

10.2

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

5.8

7.7

3498B

ICD-9 Finland

Other and unspecified disorders of the nervous system, Other specified disorders of nervous system[ENCEPHALOPATHIA TOXICA]

+∞

7.4

G45.9

ICD-10 Finland

Transient cerebral ischaemic attack, unspecified

+∞

7.4

TK800

NOMESCO Finland

Hemodialysis

14.2

6.8

Z94.4

ICD-10 Finland

Liver transplant status

+∞

6.3

N06AX11

ATC

mirtazapine; oral

3.9

6.2

118

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

3.7

6.1

128

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3009508) Creatinine [Moles/volume] in Urine

211

3.53

6.52

4.6

3.0

8.2

8.1

mmol/l

0.02

169

(3022145) Colonoscopy Study observation

4.20

6.46

1.7

1.3

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

122

3.48

6.05

2.0

1.8

575.1

439.7

pmol/l

0.48

103

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

279

3.30

5.51

9.6

7.4

1.2

mmol/l

0.01

232

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

264

3.19

5.36

7.7

6.7

1.2

mmol/l

0.31

239

(3012544) pH of Venous blood

3.94

5.32

2.6

5.1

—

(3019309) Folate [Moles/volume] in Red Blood Cells

118

3.23

5.23

2.2

1.8

1350.8

1295.7

nmol/l

0.07

(3024561) Albumin [Mass/volume] in Serum or Plasma

251

2.90

4.67

12.6

5.2

33.6

35.4

g/l

1.40

239

(3020682) Albumin/Creatinine [Ratio] in Urine

218

2.85

4.61

5.2

3.8

5.8

9.2

mg/mmol

0.40

136

(3027945) Reticulocytes/100 erythrocytes in Blood

3.46

4.44

1.6

2.8

1.6

2.0

1.97

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

3.79

4.15

5.4

2.1

4.7

5.1

kpa

1.11

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

255

2.67

4.04

4.7

4.1

61.2

54.1

ng/l

0.09

191

(3012516) Albumin [Mass/volume] in Urine

205

2.63

3.98

4.2

3.2

38.8

382.6

mg/l

0.54

132

(3044640) Blood type and Crossmatch panel - Blood

199

2.60

3.86

3.1

2.6

—

(3019225) pH of Specimen

3.44

3.84

5.7

4.5

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

12.89

3.83

1.0

1.6

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

12.89

3.83

7.8

2.0

—

(3032080) INR in Blood by Coagulation assay

270

2.58

3.77

15.7

7.3

1.3

1.2

inr

0.35

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

103

2.80

3.71

1.1

1.2

1.5

0.8

u/ml

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

2.87

3.67

6.6

4.4

35.4

30.2

1.23

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

10.74

3.56

2.0

2.8

—

(3048689) Calprotectin [Mass/mass] in Stool

3.13

3.50

3.7

2.2

124.5

225.9

ug/g

0.67

(4035726)

3.30

3.41

1.2

1.3

—

(3000991) Gas panel - Venous blood

3.05

3.20

5.5

11.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

403

2.67

3.20

7.7

3.9

—

(3007164) IgA [Mass/volume] in Serum or Plasma

104

2.60

3.16

1.2

1.4

4.4

2.5

g/l

1.01

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

5.47

3.15

1.5

1.7

—

(3034770) Mitochondria Ab [Titer] in Serum

5.47

3.15

1.1

—

(36660697) Celiac disease serology panel - Serum

3.70

3.03

1.4

1.0

—

(40768797) Stomach Pathology biopsy report

2.67

3.03

1.7

1.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

272

2.28

2.95

5.2

4.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

5.40

2.80

1.0

1.4

—

(3022313) Gas panel - Capillary blood

3.46

2.76

4.8

2.0

—

(42870588) Differential panel, method unspecified - Blood

199

2.20

2.70

6.6

5.9

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

317

2.22

2.69

19.2

7.7

15.0

12.0

umol/l

0.52

304

(3003694) ABO and Rh group [Type] in Blood

150

2.27

2.69

1.5

1.3

—

(3013512) EKG study

201

2.17

2.62

5.0

4.1

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

7.56

2.59

4.8

1.7

0.8

1.0

g/l

—

(3022948) Iron [Moles/volume] in Serum or Plasma

2.41

2.57

2.5

2.3

14.3

13.7

umol/l

0.11

(3026493) Urate [Moles/volume] in Serum or Plasma

177

2.18

2.57

4.8

3.1

384.9

5754.6

umol/l

0.78

149

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

412

2.36

2.56

4.1

3.4

15.2

15.0

pmol/l

0.21

364

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

196

2.13

2.47

3.9

3.5

1679.6

1317.9

ng/l

0.19

168

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

231

2.10

2.46

4.9

2.9

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

5.34

2.45

1.0

1.1

—

(3022621) pH of Urine by Test strip

3.15

2.41

4.9

2.2

—

(3049717) Cytology report of Urine Cyto stain

3.52

2.40

3.8

2.6

—

(3021901) Oxygen saturation in Capillary blood

4.92

2.32

4.3

2.2

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

4.92

2.32

1.2

1.9

—

(1616796) Gas panel - Central venous blood

4.92

2.32

3.8

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

4.57

2.20

1.2

1.9

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

4.57

2.20

1.3

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.51

2.17

2.2

1.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.38

2.16

1.9

1.6

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

123

2.13

2.10

1.5

1.7

6.1

1.3

mg/l

0.85

101

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

149

2.03

2.01

3.0

2.5

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

4.79

1.97

1.8

163.8

241.8

—

(4146454)

4.79

1.97

1.8

2.8

—

(3023368) Bacteria identified in Blood by Culture

184

1.96

6.0

4.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.29

1.91

2.3

1.8

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

3.75

1.88

1.8

1.2

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

2.26

1.86

1.4

1.2

1.1

5.6

u/ml

—

(3029937) Albumin [Presence] in Urine by Test strip

153

1.96

1.86

6.0

3.9

0.0

estimate

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

4.39

1.85

1.0

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

3.53

1.78

1.5

1.2

—

(3018418) pH of Serum or Plasma

173

1.89

1.74

6.2

5.0

7.4

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

2.77

1.71

3.0

2.7

0.1

0.0

e6/l

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.98

1.69

1.3

1.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

3.75

1.64

1.2

1.8

—

(3000494) Fungus identified in Specimen by Culture

2.07

1.61

2.1

1.4

—

(3002256) Pathology report gross observation

2.14

1.56

1.1

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

1.56

0.0

2.2

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

2.76

1.56

2.7

3.8

30.0

337.5

u/ml

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

3.50

1.55

2.8

1.7

50.4

80.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.02

1.54

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.49

1.49

1.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.88

1.46

1.5

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.11

1.44

2.2

1.6

—

(3021601) Nitrite [Presence] in Urine by Test strip

274

1.71

1.42

4.9

4.8

0.0

estimate

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.04

1.41

4.9

8.2

—

(1761868) Lipid panel - Serum or Plasma

205

0.50

1.34

4.4

3.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.98

1.32

6.3

3.5

—

(3036489) Thrombin time

2.90

1.30

1.6

1.7

28.8

20.4

—

(3026008) Bacteria identified in Urine by Culture

161

1.73

1.29

3.8

2.8

—

(3042936) Bacteria identified in Isolate by Culture

103

1.85

1.27

2.2

1.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

1.19

0.0

1.2

—

(3028026) IgM [Mass/volume] in Serum or Plasma

2.07

1.13

1.4

1.6

1.4

1.1

g/l

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.48

1.11

1.8

2.7

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.48

1.11

2.2

2.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.14

1.10

5.0

1.7

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.09

1.08

1.7

2.5

13.2

9.2

g/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

242

1.57

1.06

2.8

2.0

89.7

92.3

pmol/l

0.16

134

(36304419) Bacteria [Presence] in Urine

187

1.61

1.06

4.8

2.7

—

(3009261) Glucose [Presence] in Urine by Test strip

280

1.56

1.05

4.6

3.6

0.0

estimate

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

527

1.78

1.05

5.9

4.0

2.1

1.9

mu/l

0.28

463

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

1.00

0.0

1.9

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.04

1.00

1.1

1.2

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.87

0.99

1.3

1.7

314.2

349.8

nmol/l

—

(4010399)

1.95

0.97

1.6

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

593

1.88

0.95

30.3

15.6

16.5

25.3

mg/l

2.59

468

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.24

0.94

3.0

2.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.71

0.93

1.7

2.0

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.16

0.91

1.8

2.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

213

1.51

0.87

5.8

3.9

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.95

0.84

5.0

3.4

27.0

25.4

mmol/l

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.75

0.82

6.8

3.1

42.3

28.3

u/l

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.81

0.0

5.5

—

(3035350) Ketones [Presence] in Urine by Test strip

273

1.46

0.80

5.0

3.6

0.0

estimate

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.80

0.0

1.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

317

0.68

0.78

2.4

2.5

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.26

0.78

1.2

—

(40768804) Tissue Pathology biopsy report

229

1.44

0.73

2.8

2.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.91

0.70

1.4

1.3

—

(3000492) Spirometry study

1.65

0.67

2.0

1.7

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

310

0.71

0.66

3.2

4.6

18.7

21.7

0.89

163

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.71

0.62

1.4

1.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.78

0.59

1.5

1.6

—

(3025941) Bacteria identified in Stool by Culture

1.78

0.59

1.0

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

153

1.42

0.59

5.8

3.3

—

(40758558) Short blood count panel - Blood

148

1.38

0.50

9.9

6.5

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.58

0.50

1.3

1.6

63.8

66.7

g/l

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.52

0.47

1.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.66

0.44

2.0

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.47

0.42

1.7

1.8

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.41

0.0

1.5

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.41

0.0

3.4

—

1.6

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.41

0.0

3.4

—

7.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

573

1.39

0.41

31.2

14.9

70.4

79.1

ml/min/173m2

1.44

468

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

584

1.41

0.41

7.1

4.8

6.3

6.1

mmol/l

0.55

525

(3009542) Hematocrit [Volume Fraction] of Blood

529

0.78

0.39

29.6

16.2

37.4

39.8

1.02

363

(3002385) Erythrocyte distribution width [Ratio]

479

0.80

0.36

40.9

19.3

14.3

13.8

2.05

473

(3044889) 12 lead EKG panel

430

0.80

0.36

5.0

4.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.40

0.35

4.7

2.8

144.8

125.6

g/l

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

570

1.30

0.30

10.7

6.2

42.6

40.5

mmol/mol

0.63

534

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.38

0.24

1.8

1.6

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

3.4

—

4.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

3.4

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

3.4

—

105.9

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.21

0.0

2.8

—

(40761535) Cells panel - Urine sediment

1.30

0.21

3.3

3.6

—

(40761511) CBC panel - Blood by Automated count

609

1.25

0.19

32.9

15.0

—

(3015736) pH of Urine

206

1.17

0.19

4.6

3.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

583

1.16

0.13

6.6

4.1

1.2

1.3

mmol/l

0.38

529

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

392

1.10

0.11

5.0

4.9

1.8

3.1

ug/l

0.91

351

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.12

0.10

7.2

6.8

23.9

24.1

mmol/l

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

596

1.14

0.09

7.2

4.6

4.1

4.5

mmol/l

2.14

549

(40761536) Microorganisms panel - Urine sediment

1.12

0.09

5.5

4.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.04

0.08

1.3

1.6

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

597

1.13

0.08

7.4

4.6

1.3

1.4

mmol/l

0.46

545

(3011397) Hemoglobin [Presence] in Urine by Test strip

128

1.12

0.07

3.4

3.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

612

1.09

0.03

7.6

5.2

2.4

2.6

mmol/l

1.88

559

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.0

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.3

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.3

—

180.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(3035880) pH of Pleural fluid

0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

14.3

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.4

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.3

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

0.0

2.7

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.3

—

15.3

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.6

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.2

—

28.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

130

1.00

0.00

7.3

6.3

—

(3000012) Reticulocyte production index

0.00

0.0

2.6

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.7

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

4.3

—

3.1

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.2

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.5

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.3

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

644

1.08

0.00

36.9

18.4

99.8

84.1

umol/l

1.46

644

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

5.2

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

2.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

3.5

—

21.3

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.2

—

14.3

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.0

1.0

—

6.8

—

(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose

0.00

0.0

1.2

—

8.0

—

(3003181) Sodium [Moles/volume] in Urine

0.00

0.0

1.3

—

65.7

—

(3004451) EKG impression Narrative

0.00

0.0

1.3

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.6

—

10.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_ENCEPHTOX and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
G6_ENCEPHTOX	3.789 [2.76, 5.19]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 140 out of 333 males with G6_ENCEPHTOX died.

Mortality risk

Mortality risk for people of age

years, who have G6_ENCEPHTOX.

N-year risk	Females	Males
1	No data	0.655%
5	No data	4.068%
10	No data	10.518%
15	No data	18.887%
20	No data	30.332%

Relationships between endpoints

↥

Index endpoint: G6_ENCEPHTOX – Toxic encephalopathy

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Toxic encephalopathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints