No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
139 |
4. Check minimum number of eventsNone |
139 |
5. Include endpointsNone |
139 |
6. Filter based on genotype QC (FinnGen only) |
139 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G57
- Name in latin
- Morbositas nervi tibialis
Similar endpoints
↥List of similar endpoints to
Lesion of medial popliteal nerve
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 945 | 503 | 441 |
| Only index persons | 875 | 470 | 405 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.49 | 52.31 | 48.40 |
| Only index persons | 49.98 | 51.67 | 48.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 139 | 91 | 48 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 54.13 | 54.17 | 54.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 121
- Matched controls
- 1208
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G57.4
ICD-10 Finland
Lesion of medial popliteal nerve
+∞
148.3
110
*
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
+∞
26.0
24
*
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
148.2
23.5
24
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
22.6
16.8
24
13
N03AX16
ATC
pregabalin; oral
5.8
15.6
53
143
M79.6
ICD-10 Finland
Pain in limb
4.2
12.5
69
290
N02AX02
ATC
tramadol; systemic, rectal
3.7
10.6
69
321
3554A
ICD-9 Finland
Mononeuritis of lower limb, Lesion of medial popliteal nerve
+∞
10.6
10
*
N03AX12
ATC
gabapentin; oral
4.8
10.0
36
98
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.3
9.2
76
407
ZXA05
NOMESCO Finland
Left side
3.7
9.1
47
176
ACC51
NOMESCO Finland
Release of median nerve
36.0
8.2
10
*
G57.5
ICD-10 Finland
Tarsal tunnel syndrome
85.1
7.5
8
*
G57.8
ICD-10 Finland
Other mononeuropathies of lower limb
85.1
7.5
8
*
M25.5
ICD-10 Finland
Pain in joint
3.1
7.4
50
223
J01MA14
ATC
moxifloxacin; systemic
4.9
7.3
24
58
XA402
NOMESCO Finland
ENMG
21.6
7.3
10
5
G57.6
ICD-10 Finland
Lesion of plantar nerve
32.1
7.3
9
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
5.4
7.1
21
45
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
3.8
7.1
32
105
M77.4
ICD-10 Finland
Metatarsalgia
6.2
6.9
18
33
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.8
6.5
28
88
ZXA00
NOMESCO Finland
Right side
3.0
6.4
44
196
ACB19
NOMESCO Finland
Excision of lesion of peripheral nerve other or unspecified
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint G6_FEMMEPOP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_FEMMEPOP | 1.318 [0.96, 1.81] | 0.09 |
| Birth year | 0.994 [0.99, 1.0] | 0.183 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 398 females with G6_FEMMEPOP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_FEMMEPOP | 1.459 [1.03, 2.06] | 0.033 |
| Birth year | 0.989 [0.98, 1.0] | 0.025 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 344 males with G6_FEMMEPOP died.
Mortality risk
Mortality risk for people of age
years, who have G6_FEMMEPOP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.125% | 0.326% |
| 5 | 0.826% | 1.77% |
| 10 | 1.935% | 4.382% |
| 15 | 3.731% | 8.464% |
| 20 | 6.789% | 14.152% |
Relationships between endpoints
↥Index endpoint: G6_FEMMEPOP – Lesion of medial popliteal nerve
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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