Lesion of medial popliteal nerve

G6_FEMMEPOP

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G57.4 Hospital discharge: ICD-9 — 3554 Cause of death: ICD-10 — G57.4 Cause of death: ICD-9 — 3554 2 out of 7 registries used, show all original rules.	143
4. Check minimum number of events None	143
5. Include endpoints None	143
6. Filter based on genotype QC (FinnGen only)	139

Control definitions (FinnGen only)

Control exclude: G6_NERPLEX

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G57
Name in latin: Morbositas nervi tibialis

NAME	G6_FEMMEPOP
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G574
HD_ICD_9	3554
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G574
COD_ICD_9	3554
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Lesion of medial popliteal nerve based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	945	503	441
Only index persons	875	470	405
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	50.49	52.31	48.40
Only index persons	49.98	51.67	48.03

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	139	91	48
Unadjusted period prevalence (%)	0.03	0.03	0.02
Median age at first event (years)	54.13	54.17	54.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
143: Matched controls
1430

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G57.4

ICD-10 Finland

Lesion of medial popliteal nerve

+∞

179.5

132

G57.3

ICD-10 Finland

Lesion of lateral popliteal nerve

+∞

36.0

ACC59

NOMESCO Finland

Decompression and freeing of adhesions of peripheral nerve: other or unspecified

180.2

28.8

N03AX16

ATC

[U] pregabalin

5.6

22.5

177

N03AX12

ATC

[U] gabapentin; oral

5.7

19.5

114

M79.6

ICD-10 Finland

Pain in limb

4.4

16.8

392

G56.0

ICD-10 Finland

Carpal tunnel syndrome

16.4

16.3

N02AX02

ATC

tramadol; systemic, rectal

3.6

12.9

404

ACC51

NOMESCO Finland

Release of median nerve

130.0

11.6

M77.4

ICD-10 Finland

Metatarsalgia

5.5

10.9

M19.0

ICD-10 Finland

Primary arthrosis of other joints

4.5

10.6

3554A

ICD-9 Finland

Mononeuritis of lower limb, Lesion of medial popliteal nerve

+∞

10.5

N06AX21

ATC

duloxetine; oral

4.4

10.5

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

4.4

10.4

L17

ICPC

Foot/toe symptom/complaint

3.2

10.2

270

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

3.6

9.8

134

XA402

NOMESCO Finland

ENMG

19.2

9.6

G57.6

ICD-10 Finland

Lesion of plantar nerve

23.6

9.5

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

3.0

9.5

468

J01MA14

ATC

moxifloxacin; systemic

4.3

8.8

N06AA09

ATC

amitriptyline; systemic

4.1

8.7

G57.8

ICD-10 Finland

Other mononeuropathies of lower limb

95.4

8.5

G57.5

ICD-10 Finland

Tarsal tunnel syndrome

+∞

8.4

N05CD07

ATC

temazepam; oral

3.9

8.3

N02BF01

ATC

gabapentin; oral

4.5

7.3

ZXD10

NOMESCO Finland

Scheduled procedure

2.6

7.3

376

ZXA05

NOMESCO Finland

Left side

2.8

7.3

218

ZXA00

NOMESCO Finland

Right side

2.8

7.2

219

T93.2

ICD-10 Finland

Sequelae of other fractures of lower limb

31.8

7.2

R52.2

ICD-10 Finland

Other chronic pain

8.2

7.1

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

3.3

7.0

101

M25.5

ICD-10 Finland

Pain in joint

2.5

6.7

332

NHU20

NOMESCO Finland

Removal of internal fixation device from ankle or foot

7.2

6.5

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

3.1

6.3

113

ACC55

NOMESCO Finland

Release of tibial nerve

+∞

6.3

ACB19

NOMESCO Finland

Excision of lesion of peripheral nerve other or unspecified

+∞

6.3

ACC54

NOMESCO Finland

Release of peroneal nerve

+∞

6.3

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

3.8

6.3

K21.0

ICD-10 Finland

Gastro-oesophageal reflux disease with oesophagitis

3.5

6.0

B01AB05

ATC

enoxaparin; parenteral

2.4

6.0

298

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3013115) Eosinophils [#/volume] in Blood

577

2.23

5.13

4.5

6.4

0.19

0.18

e9/l

0.20

513

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

544

2.19

4.98

5.5

5.9

1.22

mmol/l

0.05

462

(3001604) Monocytes [#/volume] in Blood

558

2.16

4.82

4.4

5.9

0.57

0.56

e9/l

0.11

494

(3006315) Basophils [#/volume] in Blood

559

2.16

4.78

4.4

5.9

0.04

e9/l

0.29

495

(3019198) Lymphocytes [#/volume] in Blood

570

2.15

4.73

4.4

5.9

1.85

1.97

e9/l

0.25

515

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

202

2.36

4.68

4.0

3.5

163.63

316.87

ng/l

0.33

153

(40760892) CBC W Ordered Manual Differential panel - Blood

533

2.02

4.11

4.8

6.9

—

(3018418) pH of Serum or Plasma

348

2.06

4.10

2.8

3.7

7.41

7.40

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

669

2.05

4.05

5.1

9.5

4.28

3.92

e9/l

0.65

580

(3013826) Glucose [Moles/volume] in Serum or Plasma

631

2.03

4.01

6.1

4.1

6.98

6.60

mmol/l

0.75

584

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

438

2.00

3.96

2.2

1.7

93.75

98.63

pmol/l

0.31

191

(3042936) Bacteria identified in Isolate by Culture

157

2.34

3.95

2.5

1.8

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

7.62

3.91

1.4

1.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

117

2.49

3.86

1.8

1.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

135

1193

3.35

3.62

18.9

12.0

23.24

22.46

mg/l

0.08

118

896

(3023368) Bacteria identified in Blood by Culture

270

2.04

3.62

4.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.87

3.60

1.4

—

(40768797) Stomach Pathology biopsy report

156

2.26

3.60

1.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

256

2.04

3.54

1.9

1.7

0.60

1.05

mg/l

2.05

208

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

117

2.38

3.41

2.2

1.8

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

2.64

3.19

1.3

1.2

—

43.26

—

(3021589) Normoblasts [#/volume] in Blood

513

1.81

3.05

6.7

8.9

0.01

0.00

e9/l

0.46

417

(3004588) Protein electrophoresis panel - Serum or Plasma

2.62

3.01

1.4

2.0

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

246

1.93

2.97

2.6

1.9

2.88

3.27

mg/l

0.50

210

(40758558) Short blood count panel - Blood

288

1.88

2.93

3.5

6.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

114

2.21

2.75

2.5

1.8

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

3.93

2.72

1.6

1.2

0.00

g/l

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

3.93

2.72

1.6

1.2

0.00

g/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

168

1.99

2.63

2.4

1.9

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.48

2.59

1.3

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

503

1.72

2.58

3.1

2.3

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

3.62

2.53

1.6

1.3

0.00

g/l

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

128

1127

2.29

2.47

5.0

4.5

1.98

1.94

mu/l

0.10

123

1017

(3022621) pH of Urine by Test strip

2.38

2.4

2.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

130

1156

2.37

15.4

11.3

82.56

81.58

ml/min/173m2

0.21

109

930

(3000494) Fungus identified in Specimen by Culture

136

2.02

2.36

1.4

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.62

2.30

1.5

1.1

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.42

2.17

2.2

1.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.42

2.17

2.2

1.0

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

262

1.73

2.14

1.3

0.96

1.44

u/ml

0.33

(36660697) Celiac disease serology panel - Serum

2.19

2.11

1.5

1.2

—

(3044927) Protein electrophoresis panel - Urine

5.14

2.09

1.0

1.1

—

(3018095) Leukocytes [#/volume] in Urine

404

1.63

2.08

4.4

3.3

150.45

107.80

e6/l

0.12

279

(3002582) Erythrocytes [#/volume] in Urine

333

1.66

2.07

3.4

2.8

14.42

52.24

e6/l

1.17

248

(3017143) Hepatitis C virus Ab [Presence] in Serum

113

2.01

2.05

1.6

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

4.67

1.95

1.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.21

1.94

1.4

1.5

—

(3026008) Bacteria identified in Urine by Culture

339

1.63

1.92

3.6

2.7

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.51

1.90

1.1

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

131

1190

2.20

1.89

4.7

4.4

6.17

5.89

mmol/l

1.13

126

1085

(3044889) 12 lead EKG panel

100

843

1.62

1.86

3.4

3.6

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

3.15

1.82

1.9

2.7

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

3.15

1.82

2.1

1.3

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.86

1.82

1.5

—

(3044640) Blood type and Crossmatch panel - Blood

343

1.60

1.82

3.2

2.1

—

(3052851) Hemolysis interference index of Serum or Plasma

2.76

1.75

3.6

3.3

—

(3023410) Appearance of Cerebral spinal fluid

3.94

1.73

1.2

—

(3009508) Creatinine [Moles/volume] in Urine

338

1.58

1.72

3.3

3.0

7.63

7.59

mmol/l

0.02

282

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

392

1.56

1.72

3.3

2.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

235

1.65

1.69

1.3

1.4

2.95

2.18

g/l

1.11

143

(3012516) Albumin [Mass/volume] in Urine

322

1.58

1.68

3.8

3.1

1165.37

456.69

mg/l

0.27

207

(3024928) Oxygen saturation in Venous blood

3.25

1.68

2.3

3.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

261

1.62

1.68

4.0

2.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

795

1.53

1.60

4.5

3.8

—

(3022217) INR in Platelet poor plasma by Coagulation assay

511

1.50

1.57

13.4

10.6

1.10

1.20

inr

0.62

139

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

758

1.51

1.54

2.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

346

1.53

1.54

3.9

3.7

3.88

6.00

mg/mmol

0.43

214

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

157

1.72

1.53

3.3

2.6

2.46

3.17

e6/l

—

(3014051) Protein [Presence] in Urine by Test strip

2.94

1.52

1.8

2.0

—

(3030467) Casts [#/volume] in Urine by Automated count

305

1.53

1.45

3.4

2.6

0.25

0.39

e6/l

0.45

219

(3028271) Lactate [Moles/volume] in Capillary blood

3.20

1.45

1.4

2.3

2.80

1.47

mmol/l

—

(3028707) Methadone [Presence] in Urine by Screen method

3.20

1.45

1.6

1.3

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

2.80

1.45

1.3

1.4

—

20.16

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.80

1.45

1.5

1.3

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.80

1.45

3.8

1.6

—

(3019309) Folate [Moles/volume] in Red Blood Cells

185

1.64

1.43

1.5

1.6

936.38

1247.22

nmol/l

1.59

135

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.17

1.42

16.2

7.9

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

177

1.65

1.42

3.2

2.3

0.70

0.88

e6/l

0.23

(3011397) Hemoglobin [Presence] in Urine by Test strip

254

1.56

1.41

3.6

3.0

—

(3016879) Cocaine [Presence] in Urine

2.48

1.41

1.4

1.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

482

1.46

1.40

2.4

2.1

89.69

78.64

nmol/l

1.61

428

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.68

1.38

1.2

1.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

3.01

1.37

1.2

1.4

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

3.01

1.37

1.2

2.5

—

(3021901) Oxygen saturation in Capillary blood

3.01

1.37

2.2

2.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

131

1.71

1.33

1.9

1.5

—

(4035726) Immunohistochemistry procedure

115

0.41

1.32

1.4

1.5

—

(3044290) Cell count panel - Cerebral spinal fluid

2.56

1.32

1.0

1.1

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

108

1.76

1.29

2.4

5.6

226.17

242.67

u/l

0.21

101

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.11

1.29

2.1

1.7

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

191

1.58

1.26

1.3

1.26

11.05

u/ml

1.81

(3014576) Chloride [Moles/volume] in Serum or Plasma

125

1.70

1.26

10.2

5.7

103.90

103.94

mmol/l

0.01

125

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.46

1.25

1.7

1.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

132

1234

1.91

1.24

5.3

4.9

2.87

2.84

mmol/l

0.12

125

1135

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.69

1.22

1.4

1.9

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.96

1.22

1.9

1.7

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

130

1211

1.81

1.22

4.4

4.82

4.77

mmol/l

0.26

124

1123

(3008037) Lactate [Moles/volume] in Venous blood

2.36

1.20

1.7

3.0

1.10

1.37

mmol/l

—

(3033658) Prothrombin time (PT) actual/Normal

281

1.48

1.20

4.4

3.2

91.11

94.23

0.37

274

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

126

1166

1.68

1.18

3.9

1.53

1.27

mmol/l

3.06

120

1072

(3045414) Leukocytes [Presence] in Urine

2.11

1.17

1.5

1.6

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.11

1.17

1.6

1.8

—

(3027315) Oxygen [Partial pressure] in Blood

2.55

1.16

3.6

3.4

8.90

7.91

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.55

1.16

3.6

3.4

5.04

5.14

kpa

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.75

1.16

2.1

3.8

5.63

5.86

kpa

0.55

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.06

1.14

1.8

2.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

413

1.41

1.12

3.6

3.5

1232.01

32.60

ng/l

0.50

282

(3027008) Opiates [Presence] in Urine

2.25

1.09

1.4

1.3

—

(3028300) Cannabinoids [Presence] in Urine

2.25

1.09

1.4

1.3

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.07

1.07

1.8

3.9

24.67

24.40

mmol/l

—

(3027944) Amphetamines [Presence] in Urine

2.18

1.07

1.4

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

2.18

1.07

1.4

1.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

199

1.51

1.06

1.3

1.4

—

(36304419) Bacteria [Presence] in Urine

306

1.43

1.05

3.4

2.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.11

1.04

1.6

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

1.93

1.02

1.3

2.4

1.54

1.53

g/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

103

0.47

0.93

1.2

1.6

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

128

1205

1.59

0.91

4.4

1.48

1.50

mmol/l

0.17

121

1111

(3026782) Osmolality of Urine

207

1.44

0.88

3.0

2.8

551.14

543.21

mosm/kgh2o

0.08

180

(3024354) Oxygen [Partial pressure] in Venous blood

1.69

0.88

2.1

2.7

4.49

4.31

kpa

0.23

(40761511) CBC panel - Blood by Automated count

132

1254

1.68

0.87

12.5

11.5

—

(3049717) Cytology report of Urine Cyto stain

1.91

0.82

2.0

2.9

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.85

0.80

1.5

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

168

1.44

0.78

2.3

1.8

—

(3000330) Specific gravity of Urine by Test strip

1.74

0.77

3.4

3.3

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.21

0.77

1.4

1.8

—

(3038515) Glucose [Moles/volume] in Venous blood

2.12

0.75

1.8

3.1

6.96

8.14

mmol/l

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.68

0.75

13.3

6.1

25.77

24.93

mmol/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

143

0.60

0.74

7.1

6.6

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

2.04

0.73

2.4

4.6

17.00

34.44

mg/l

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.79

0.72

1.0

1.4

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.96

0.71

1.8

1.4

—

(3037756) Immunofixation for Serum or Plasma

1.88

0.69

1.0

1.7

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.66

0.67

2.7

2.9

4.62

4.45

pmol/l

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.75

0.64

1.8

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.75

0.64

1.4

1.9

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.69

0.62

1.4

1.8

—

(3003694) ABO and Rh group [Type] in Blood

278

1.29

0.59

1.3

—

(3022145) Colonoscopy Study observation

133

1.40

0.58

1.2

1.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.74

0.58

3.3

2.4

—

(3000991) Gas panel - Venous blood

1.51

0.56

13.8

6.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.56

0.56

1.2

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

117

1.41

0.55

2.3

3.1

—

(40761536) Microorganisms panel - Urine sediment

0.60

0.54

6.2

3.2

—

(1002224) Polysomnography panel

1.46

0.53

1.2

1.1

—

(3015736) pH of Urine

473

1.23

0.52

3.9

2.9

5.75

5.72

—

(3019060) Gas panel - Arterial blood

1.43

0.52

6.9

4.8

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.48

0.49

1.3

1.6

0.91

1.59

g/l

1.07

(21494755) Public health laboratory ask at order entry panel

140

0.69

0.46

1.8

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

204

1.27

0.44

1.4

1.3

15.98

26.61

iu/ml

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.41

0.44

4.8

2.6

6.05

7.93

ug/l

0.19

(3029937) Albumin [Presence] in Urine by Test strip

312

0.80

0.44

5.2

3.3

0.00

estimate

—

105

(3001019) Free T4 and TSH panel - Serum or Plasma

1.45

0.43

2.3

1.5

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.63

0.43

1.4

1.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.58

0.42

1.0

2.3

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.41

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.41

0.0

2.2

—

(3002256) Pathology report gross observation

160

1.29

0.41

1.5

1.3

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.41

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.40

0.0

1.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.39

0.39

1.2

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.45

0.36

1.7

1.9

42.33

38.81

nmol/l

—

(3022313) Gas panel - Capillary blood

1.45

0.36

2.8

3.4

—

(3000492) Spirometry study

109

1.32

0.35

1.5

1.3

—

(1761868) Lipid panel - Serum or Plasma

479

0.85

0.34

2.9

2.8

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.38

0.33

2.8

1.5

—

(3035350) Ketones [Presence] in Urine by Test strip

581

1.15

0.32

4.4

3.2

0.00

estimate

—

115

(3008898) HLA-B27 [Presence]

1.36

0.31

1.1

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.31

0.31

3.1

41.67

49.33

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.26

0.30

1.9

2.4

0.66

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.24

0.29

2.0

2.4

1.19

1.13

—

(3009343) pH of Capillary blood

1.31

0.28

2.4

3.2

—

7.40

—

(40768804) Tissue Pathology biopsy report

510

1.13

0.25

2.5

2.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.33

0.23

1.0

1.7

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

3.3

—

32.45

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

19.3

—

2017.09

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

20.14

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.4

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

12.1

—

1052.00

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.21

0.0

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.1

—

2.95

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

4.1

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

2.3

—

(3014037) CD3+CD4+ (T4 helper) cells/100 cells in Blood

0.00

0.21

0.0

3.8

—

47.67

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.21

0.0

1.0

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

0.21

0.0

2.3

—

34.73

—

(3021601) Nitrite [Presence] in Urine by Test strip

584

1.11

0.21

6.6

4.3

0.00

estimate

—

105

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.4

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

2.98

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.20

0.0

4.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.18

0.18

1.0

1.1

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

244

1.13

0.18

3.6

4.0

23.81

21.76

—

106

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.14

0.17

2.4

2.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

120

0.82

0.17

1.8

1.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

460

0.91

0.17

4.8

3.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

101

1.21

0.17

1.6

1.3

—

(3017732) Neutrophils [#/volume] in Blood

0.79

0.16

1.0

1.7

3.55

7.90

e9/l

—

(40761535) Cells panel - Urine sediment

1.22

0.16

3.6

3.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

336

0.90

0.16

4.6

2.9

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.81

0.15

1.6

1.5

—

(3019150) Specific gravity of Urine by Refractometry

252

1.09

0.10

4.2

3.3

1.01

1.02

kg/l

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.14

0.10

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.14

0.10

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.12

0.10

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.15

0.09

3.7

1.8

—

(3013512) EKG study

338

0.93

0.09

3.9

3.6

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.07

0.09

2.7

3.4

24.27

25.26

mmol/l

—

(4200892) Spirometry reversibility

1.15

0.08

1.8

1.5

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

183

0.92

0.07

1.8

2.7

0.59

0.69

ug/l

—

115

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

101

0.88

0.06

3.8

3.9

1.24

1.23

mmol/l

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

104

0.96

0.00

1.2

2.1

0.19

0.22

g/l

—

(3019225) pH of Specimen

103

0.97

0.00

2.1

3.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

203

0.98

0.00

2.0

1.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

108

1.02

0.00

4.0

2.0

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.2

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3035062) Alkaline phosphatase.liver 1 [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

91.14

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

2.0

—

(3012565) Volume of 24 hour Urine

0.00

-0.00

0.0

1.8

—

1815.83

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

1116.29

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.2

—

9.93

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.2

—

120.80

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

8.34

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

2.2

—

10.67

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.2

—

(3036185) Alkaline phosphatase.liver 2 [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

32.86

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3035880) pH of Pleural fluid

0.00

-0.00

0.0

1.0

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.3

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

-0.00

0.0

4.3

—

45.14

—

(3025941) Bacteria identified in Stool by Culture

0.92

-0.00

1.3

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.89

-0.00

1.3

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.7

—

16.77

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.6

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

2.0

—

(3020013) Alkaline phosphatase.intestinal [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

8.62

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

1.9

—

13.00

—

(3004446) Plasmodium sp identified in Blood by Light microscopy

0.00

-0.00

0.0

3.0

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

-0.00

0.0

2.9

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.4

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

-0.00

0.0

1.5

—

7.67

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

-0.00

0.0

9.2

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_FEMMEPOP and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_FEMMEPOP	1.318 [0.96, 1.81]	0.09
Birth year	0.994 [0.99, 1.0]	0.183

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 398 females with G6_FEMMEPOP died.

Males

Parameter	HR [95% CI]	p-value
G6_FEMMEPOP	1.459 [1.03, 2.06]	0.033
Birth year	0.989 [0.98, 1.0]	0.025

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 344 males with G6_FEMMEPOP died.

Mortality risk

Mortality risk for people of age

years, who have G6_FEMMEPOP.

N-year risk	Females	Males
1	0.125%	0.326%
5	0.826%	1.77%
10	1.935%	4.382%
15	3.731%	8.464%
20	6.789%	14.152%

Relationships between endpoints

↥

Index endpoint: G6_FEMMEPOP – Lesion of medial popliteal nerve

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Lesion of medial popliteal nerve

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints