Lesion of medial popliteal nerve

G6_FEMMEPOP

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G57.4 Hospital discharge: ICD-9 — 3554 Cause of death: ICD-10 — G57.4 Cause of death: ICD-9 — 3554 2 out of 7 registries used, show all original rules.	139
4. Check minimum number of events None	139
5. Include endpoints None	139
6. Filter based on genotype QC (FinnGen only)	139

Control definitions (FinnGen only)

Control exclude: G6_NERPLEX

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G57
Name in latin: Morbositas nervi tibialis

NAME	G6_FEMMEPOP
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G574
HD_ICD_9	3554
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G574
COD_ICD_9	3554
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Lesion of medial popliteal nerve based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	945	503	441
Only index persons	875	470	405
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	50.49	52.31	48.40
Only index persons	49.98	51.67	48.03

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	139	91	48
Unadjusted period prevalence (%)	0.03	0.03	0.02
Median age at first event (years)	54.13	54.17	54.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
121: Matched controls
1208

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G57.4

ICD-10 Finland

Lesion of medial popliteal nerve

+∞

148.3

110

ACC59

NOMESCO Finland

Decompression and freeing of adhesions of peripheral nerve: other or unspecified

+∞

26.0

G57.3

ICD-10 Finland

Lesion of lateral popliteal nerve

148.2

23.5

G56.0

ICD-10 Finland

Carpal tunnel syndrome

22.6

16.8

N03AX16

ATC

pregabalin; oral

5.8

15.6

143

M79.6

ICD-10 Finland

Pain in limb

4.2

12.5

290

N02AX02

ATC

tramadol; systemic, rectal

3.7

10.6

321

3554A

ICD-9 Finland

Mononeuritis of lower limb, Lesion of medial popliteal nerve

+∞

10.6

N03AX12

ATC

gabapentin; oral

4.8

10.0

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

3.3

9.2

407

ZXA05

NOMESCO Finland

Left side

3.7

9.1

176

ACC51

NOMESCO Finland

Release of median nerve

36.0

8.2

G57.5

ICD-10 Finland

Tarsal tunnel syndrome

85.1

7.5

G57.8

ICD-10 Finland

Other mononeuropathies of lower limb

85.1

7.5

M25.5

ICD-10 Finland

Pain in joint

3.1

7.4

223

J01MA14

ATC

moxifloxacin; systemic

4.9

7.3

XA402

NOMESCO Finland

ENMG

21.6

7.3

G57.6

ICD-10 Finland

Lesion of plantar nerve

32.1

7.3

M19.0

ICD-10 Finland

Primary arthrosis of other joints

5.4

7.1

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

3.8

7.1

105

M77.4

ICD-10 Finland

Metatarsalgia

6.2

6.9

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

3.8

6.5

ZXA00

NOMESCO Finland

Right side

3.0

6.4

196

ACB19

NOMESCO Finland

Excision of lesion of peripheral nerve other or unspecified

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

531

2.26

5.20

5.2

6.0

1.2

mmol/l

0.12

447

(42870588) Differential panel, method unspecified - Blood

349

2.27

5.14

3.6

6.0

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

197

2.36

4.57

3.9

3.5

35.4

325.0

ng/l

1.03

149

(3018418) pH of Serum or Plasma

339

2.16

4.50

2.8

3.7

7.4

—

(3006315) Basophils [#/volume] in Blood

545

2.10

4.39

4.6

6.0

0.0

e9/l

0.39

482

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.88

4.32

1.4

—

(3013115) Eosinophils [#/volume] in Blood

562

2.06

4.15

4.7

6.3

0.2

e9/l

0.38

499

(3001604) Monocytes [#/volume] in Blood

544

2.05

4.12

4.5

6.0

0.6

e9/l

0.26

481

(3019198) Lymphocytes [#/volume] in Blood

554

2.05

4.10

4.5

6.0

1.9

2.0

e9/l

0.21

498

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

7.64

3.91

1.4

1.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

117

2.50

3.87

1.8

1.4

—

(40768797) Stomach Pathology biopsy report

154

2.30

3.72

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

433

1.94

3.58

2.2

1.8

92.9

98.1

pmol/l

0.34

191

(3042936) Bacteria identified in Isolate by Culture

157

2.25

3.55

2.5

1.8

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

652

1.95

3.50

5.3

9.4

4.3

3.9

e9/l

0.64

564

(3023368) Bacteria identified in Blood by Culture

269

1.99

3.35

4.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

131

1162

3.21

3.32

19.1

12.1

23.0

22.8

mg/l

0.03

116

871

(3021589) Normoblasts [#/volume] in Blood

500

1.86

3.20

6.6

9.1

0.0

e9/l

0.47

409

(3004588) Protein electrophoresis panel - Serum or Plasma

2.63

3.01

1.4

2.0

—

(40758558) Short blood count panel - Blood

278

1.91

3.01

3.5

6.7

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

254

1.94

2.99

2.0

1.7

0.6

1.1

mg/l

1.86

206

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

246

1.95

2.99

2.6

1.9

2.9

3.2

mg/l

0.39

211

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

119

2.23

2.87

2.2

1.8

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

3.93

2.72

1.6

1.2

0.0

g/l

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

3.93

2.72

1.6

1.2

0.0

g/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

491

1.75

2.69

4.9

3.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.53

2.67

1.3

1.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

125

1094

2.42

2.61

5.0

4.5

2.0

1.9

mu/l

0.13

120

986

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

3.63

2.53

1.6

1.3

0.0

g/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

127

1124

2.50

2.49

15.7

11.4

82.3

81.5

ml/min/173m2

0.17

107

900

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

252

1.82

2.47

1.3

1.2

1.0

1.5

u/ml

0.35

(36660697) Celiac disease serology panel - Serum

2.34

2.43

1.5

1.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.79

2.40

1.5

1.1

—

(3022621) pH of Urine by Test strip

2.38

2.4

2.3

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.83

2.34

1.1

—

(3000494) Fungus identified in Specimen by Culture

138

1.99

2.28

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

116

2.07

2.26

2.5

1.8

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

2.25

2.23

2.6

2.4

—

6.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

170

1.89

2.23

2.4

1.9

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.43

2.17

2.2

1.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.43

2.17

2.2

1.0

—

(3018095) Leukocytes [#/volume] in Urine

402

1.66

2.15

4.4

3.3

150.5

107.2

e6/l

0.12

279

(3044889) 12 lead EKG panel

823

1.71

2.12

3.4

3.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

112

2.03

2.10

1.6

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

333

1.67

2.09

3.2

2.1

—

(3002582) Erythrocytes [#/volume] in Urine

333

1.67

2.09

3.4

2.8

14.4

52.2

e6/l

1.16

247

(3044927) Protein electrophoresis panel - Urine

5.14

2.09

1.0

1.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

389

1.63

2.02

3.3

2.8

—

(3026008) Bacteria identified in Urine by Culture

329

1.65

1.96

3.6

2.7

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

4.67

1.96

1.2

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.97

1.89

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

254

1.68

1.88

4.0

2.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

230

1.70

1.84

1.3

1.4

2.9

2.2

g/l

1.08

143

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.15

1.83

1.4

1.6

—

(3052851) Hemolysis interference index of Serum or Plasma

2.86

1.82

3.6

3.5

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

3.01

1.74

2.1

1.3

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

3.01

1.74

1.9

2.6

—

(3023410) Appearance of Cerebral spinal fluid

3.95

1.73

1.2

1.1

—

(3009508) Creatinine [Moles/volume] in Urine

331

1.58

1.69

3.3

3.0

7.7

7.6

mmol/l

0.06

274

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

127

1163

2.07

1.62

4.8

4.4

6.2

5.9

mmol/l

1.22

122

1058

(3012516) Albumin [Mass/volume] in Urine

317

1.57

1.60

3.8

3.1

1165.4

467.5

mg/l

0.26

202

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

156

1.73

1.57

3.3

2.6

2.5

2.9

e6/l

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

248

1.61

1.57

3.6

3.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

780

1.53

1.55

4.6

3.9

—

(3023511) Choriogonadotropin [Units/volume] in Urine

3.42

1.53

1.2

1.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.94

1.52

3.8

1.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

731

1.51

1.52

2.9

—

(3019309) Folate [Moles/volume] in Red Blood Cells

184

1.65

1.47

1.5

1.7

936.4

1242.2

nmol/l

1.55

134

(3030467) Casts [#/volume] in Urine by Automated count

305

1.54

1.46

3.4

2.6

0.3

0.4

e6/l

0.46

218

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

176

1.66

1.46

3.2

2.3

0.7

0.8

e6/l

0.17

(3021901) Oxygen saturation in Capillary blood

3.20

1.45

2.2

2.7

—

(3028271) Lactate [Moles/volume] in Capillary blood

3.20

1.45

1.4

2.3

2.8

1.4

mmol/l

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

471

1.48

1.44

2.4

2.2

89.8

78.8

nmol/l

1.55

419

(3020682) Albumin/Creatinine [Ratio] in Urine

342

1.52

1.44

4.0

3.9

4.0

6.1

mg/mmol

0.41

211

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

129

1199

2.05

1.39

5.3

4.9

2.8

mmol/l

0.14

122

1100

(3033658) Prothrombin time (PT) actual/Normal

273

1.54

1.38

4.4

3.2

91.1

94.1

0.35

266

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.68

1.38

1.2

1.3

—

(3044290) Cell count panel - Cerebral spinal fluid

2.68

1.38

1.0

—

(3024928) Oxygen saturation in Venous blood

3.01

1.37

1.2

3.4

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

3.01

1.37

1.2

2.6

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

127

1176

1.93

1.36

4.5

4.4

4.8

4.7

mmol/l

0.22

121

1086

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.17

1.33

1.8

4.0

24.7

24.6

mmol/l

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.17

1.33

2.1

1.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

131

1.71

1.33

1.9

1.5

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

189

1.60

1.32

1.3

11.4

u/ml

1.80

(3014051) Protein [Presence] in Urine by Test strip

2.84

1.29

1.6

1.9

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

109

1.75

1.26

2.4

5.5

226.2

242.2

u/l

0.20

102

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.46

1.25

1.7

1.1

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

123

1134

1.74

1.25

3.9

1.5

1.3

mmol/l

2.63

117

1041

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.79

1.23

2.1

4.0

5.6

5.9

kpa

0.53

(3045414) Leukocytes [Presence] in Urine

2.23

1.23

1.5

1.6

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.69

1.22

1.4

1.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

193

1.56

1.22

1.3

1.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.17

1.20

1.6

1.9

—

(3008037) Lactate [Moles/volume] in Venous blood

2.36

1.20

1.7

3.3

1.1

1.3

mmol/l

—

(4035726)

113

0.42

1.19

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.93

1.17

1.9

1.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.06

1.14

1.8

2.2

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.43

1.10

3.6

3.2

5.0

5.2

kpa

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.43

1.10

1.6

1.3

—

(3027315) Oxygen [Partial pressure] in Blood

2.43

1.10

3.6

3.2

8.9

7.9

kpa

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.18

1.07

1.6

1.5

—

(36304419) Bacteria [Presence] in Urine

306

1.43

1.06

3.4

2.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

408

1.39

1.05

3.6

1232.0

33.1

ng/l

0.50

278

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

1.98

1.04

1.3

2.4

1.5

g/l

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

2.32

1.04

1.4

—

20.2

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.32

1.04

1.4

1.9

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.96

1.04

15.2

8.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

125

1170

1.68

1.03

4.4

1.5

mmol/l

0.20

118

1075

(3000330) Specific gravity of Urine by Test strip

1.89

1.01

3.4

—

(3032080) INR in Blood by Coagulation assay

422

1.37

0.98

5.1

6.8

1.1

1.2

inr

0.54

121

(3024354) Oxygen [Partial pressure] in Venous blood

1.74

0.95

2.1

2.8

4.5

4.3

kpa

0.32

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

102

0.47

0.94

1.2

1.6

—

(3016879) Cocaine [Presence] in Urine

2.19

0.92

1.5

1.3

—

(3012544) pH of Venous blood

1.61

0.85

1.7

4.0

—

(3028300) Cannabinoids [Presence] in Urine

1.98

0.85

1.5

1.3

—

(3027008) Opiates [Presence] in Urine

1.98

0.85

1.5

1.3

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.91

0.83

1.5

1.6

—

(3027944) Amphetamines [Presence] in Urine

1.91

0.83

1.5

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

1.91

0.83

1.5

1.3

—

(3049717) Cytology report of Urine Cyto stain

1.85

0.80

2.0

2.9

—

(3026782) Osmolality of Urine

203

1.41

0.78

2.5

2.6

549.8

548.9

mosm/kgh2o

0.01

174

(46235355) HIV 1 and 2 tests - Meaningful Use set

168

1.44

0.78

2.3

1.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.75

0.77

13.3

6.3

25.8

25.1

mmol/l

—

(40761511) CBC panel - Blood by Automated count

128

1220

1.62

0.76

12.6

11.6

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

2.12

0.75

2.4

4.8

17.0

34.4

mg/l

—

(3038515) Glucose [Moles/volume] in Venous blood

2.12

0.75

1.8

3.5

7.0

8.1

mmol/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

142

0.61

0.74

7.1

6.5

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.84

0.73

1.0

1.3

—

(3022145) Colonoscopy Study observation

127

1.48

0.72

1.2

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

110

1.51

0.72

2.2

3.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.59

0.71

1.2

1.3

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.69

0.70

2.7

2.9

4.6

4.4

pmol/l

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.88

0.69

1.8

1.4

—

(3037756) Immunofixation for Serum or Plasma

1.81

0.67

1.0

1.7

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.81

0.67

1.8

1.4

—

(3000991) Gas panel - Venous blood

1.57

0.65

13.8

6.7

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.75

0.64

1.4

1.9

—

(3022217) INR in Platelet poor plasma by Coagulation assay

140

1.41

0.62

26.2

19.5

1.2

1.5

inr

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.69

0.62

1.4

1.8

—

(3003694) ABO and Rh group [Type] in Blood

268

1.30

0.60

1.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.75

0.58

3.3

2.4

—

(3015736) pH of Urine

443

1.24

0.54

3.8

2.9

—

(1002224) Polysomnography panel

1.48

0.54

1.2

1.1

—

(40761536) Microorganisms panel - Urine sediment

0.60

0.54

6.2

3.2

—

(3029937) Albumin [Presence] in Urine by Test strip

308

0.77

0.52

5.4

3.4

0.0

estimate

—

104

(3002256) Pathology report gross observation

157

1.32

0.46

1.6

1.3

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.43

0.46

4.8

2.6

6.0

8.1

ug/l

0.21

(3008898) HLA-B27 [Presence]

1.42

0.46

1.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.39

0.44

2.4

1.5

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.64

0.43

1.4

1.3

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.58

0.42

1.0

2.3

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.43

0.42

1.3

1.6

0.9

1.6

g/l

1.08

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.41

0.0

1.2

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

0.40

0.0

2.1

—

711.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.40

0.0

1.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.39

0.39

1.2

—

(1761868) Lipid panel - Serum or Plasma

461

0.84

0.36

3.0

2.9

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.45

0.36

1.7

1.9

42.3

38.8

nmol/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.40

0.35

2.8

1.5

—

(3022313) Gas panel - Capillary blood

1.41

0.35

2.8

3.4

—

(21494755) Public health laboratory ask at order entry panel

132

0.74

0.34

1.8

1.3

—

(40768804) Tissue Pathology biopsy report

492

1.16

0.32

2.6

2.1

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.31

0.31

2.0

2.4

1.2

1.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.31

0.31

1.0

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.31

0.31

3.1

3.4

41.7

48.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

330

0.85

0.29

4.8

2.9

—

(3009343) pH of Capillary blood

1.31

0.28

2.4

3.2

—

7.4

—

(3035350) Ketones [Presence] in Urine by Test strip

566

1.14

0.28

4.3

3.2

0.0

estimate

—

106

(3019060) Gas panel - Arterial blood

1.27

0.28

4.8

—

(3000492) Spirometry study

104

1.28

0.27

1.4

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

113

1094

1.18

0.26

19.7

12.7

40.5

40.6

0.04

806

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

448

0.88

0.24

5.0

3.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.36

0.24

1.0

1.7

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.20

0.21

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.20

0.21

1.2

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.1

—

2.9

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

4.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.5

—

(4281824)

0.00

0.21

0.0

1.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

21.0

—

1568.8

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.21

0.0

1.0

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

13.2

—

882.2

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3013512) EKG study

332

0.88

0.21

4.1

3.7

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

2.3

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

3.1

—

32.6

—

(3001467) Alkaline phosphatase.bone [Enzymatic activity/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

64.9

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

3.3

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

19.3

—

(40768800) Prostate Pathology biopsy report

0.00

0.21

0.0

1.4

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

2.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

113

0.78

0.21

1.9

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.20

0.0

1.1

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.20

0.0

4.1

—

(40761535) Cells panel - Urine sediment

1.25

0.19

3.6

3.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.14

0.17

2.4

2.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

274

1.12

0.17

5.1

5.7

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.74

0.16

1.7

1.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

237

1.12

0.15

3.7

4.0

23.8

22.0

—

103

(3021601) Nitrite [Presence] in Urine by Test strip

572

1.09

0.15

6.7

4.3

0.0

estimate

—

104

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

105

0.85

0.13

1.0

2.2

0.2

g/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.16

0.10

1.6

1.3

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.17

0.10

1.2

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.07

0.09

2.7

3.6

24.3

25.2

mmol/l

—

(3017732) Neutrophils [#/volume] in Blood

0.81

0.08

1.0

1.7

3.5

4.1

e9/l

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

100

0.89

0.06

3.8

1.2

mmol/l

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

177

0.95

0.01

1.8

2.7

0.6

0.7

ug/l

—

111

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.07

0.01

4.0

1.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

104

0.96

0.00

4.3

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

194

0.98

0.00

2.1

1.5

—

(3019150) Specific gravity of Urine by Refractometry

246

1.02

0.00

4.4

3.4

1.0

kg/l

—

(3019225) pH of Specimen

102

0.98

0.00

2.1

3.8

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.3

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

2.9

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

2.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3025941) Bacteria identified in Stool by Culture

0.96

0.00

1.3

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.4

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.0

—

(3000012) Reticulocyte production index

0.00

0.0

2.0

—

(3004446) Plasmodium sp identified in Blood by Light microscopy

0.00

0.0

3.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

2.0

—

12.9

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.6

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.6

—

15.2

—

(3035880) pH of Pleural fluid

0.00

0.0

1.0

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

8.8

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1265.7

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.4

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3012565) Volume of 24 hour Urine

0.00

0.0

1.8

—

1815.8

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.5

—

7.7

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.96

0.00

1.3

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.2

—

9.9

—

(4010399)

1.01

0.00

1.9

1.5

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

2.2

—

10.7

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.2

—

120.8

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

4.3

—

45.1

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_FEMMEPOP and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_FEMMEPOP	1.318 [0.96, 1.81]	0.09
Birth year	0.994 [0.99, 1.0]	0.183

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 398 females with G6_FEMMEPOP died.

Males

Parameter	HR [95% CI]	p-value
G6_FEMMEPOP	1.459 [1.03, 2.06]	0.033
Birth year	0.989 [0.98, 1.0]	0.025

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 344 males with G6_FEMMEPOP died.

Mortality risk

Mortality risk for people of age

years, who have G6_FEMMEPOP.

N-year risk	Females	Males
1	0.125%	0.326%
5	0.826%	1.77%
10	1.935%	4.382%
15	3.731%	8.464%
20	6.789%	14.152%

Relationships between endpoints

↥

Index endpoint: G6_FEMMEPOP – Lesion of medial popliteal nerve

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Lesion of medial popliteal nerve

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints