No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
102 |
4. Check minimum number of eventsNone |
102 |
5. Include endpointsNone |
102 |
6. Filter based on genotype QC (FinnGen only) |
99 |
Control definitions (FinnGen only)
- Control exclude
- G6_DEMYEL
Extra metadata
- Level in the ICD hierarchy
- 4
Similar endpoints
↥List of similar endpoints to
Neuromyelitis optica
based on the number of shared cases.
Similar with more cases:
- Other acute disseminated demyelination
- Demyelinating diseases of the central nervous system
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Neurological diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 99 | 80 | 19 |
| Unadjusted period prevalence (%) | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | 43.19 | 42.01 | 48.18 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 102
- Matched controls
- 1020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G36.0
ICD-10 Finland
Neuromyelitis optica [Devic]
+∞
131.9
96
*
G35
ICD-10 Finland
Multiple sclerosis
+∞
74.3
62
*
H46
ICD-10 Finland
Optic neuritis
401.5
69.9
63
*
109
Kela drug reimbursment
Multiple sclerosis
+∞
54.0
47
*
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
+∞
50.2
44
*
XCK00
NOMESCO Finland
Perimetry
26.8
49.7
39
23
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
+∞
45.2
40
*
L03AB07
ATC
interferon beta-1a; parenteral
+∞
35.5
32
*
L03AX13
ATC
glatiramer acetate; parenteral
+∞
32.0
29
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
11.2
30.6
42
60
TAB00
NOMESCO Finland
Lumbar puncture
13.1
29.1
33
36
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
+∞
28.5
26
*
ZX120
NOMESCO Finland
Intravenous
11.3
28.4
37
49
N86
ICPC
Multiple sclerosis
+∞
25.0
23
*
164
Kela drug reimbursment
Fingolimod
+∞
19.4
18
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
6.6
19.3
44
105
L04AA27
ATC
[U] fingolimod
+∞
18.3
17
*
353
Kela drug reimbursment
Cladribine and fingolimod
+∞
17.2
16
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.7
16.8
28
48
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
7.2
15.0
26
46
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
43.1
15.0
18
5
XCD10
NOMESCO Finland
Electrophysiological examination of eye
27.2
14.9
20
9
XA800
NOMESCO Finland
Neuropsychological investigation
14.0
14.5
25
23
L03AB08
ATC
interferon beta-1b; parenteral
+∞
13.9
13
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
7.1
13.4
23
40
L04AA31
ATC
[U] teriflunomide
+∞
12.8
12
*
N04BB01
ATC
amantadine; oral
73.6
11.9
13
*
2AB04, ,
NOMESCO Finland
+∞
11.7
11
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
23.4
11.6
16
8
G04BD12
ATC
mirabegron; oral
6.4
11.1
21
40
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.5
11.0
25
57
Z3226
NOMESCO Finland
Physiotherapist
4.4
10.9
36
112
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
15.4
10.6
17
13
XKD06
NOMESCO Finland
Physiologic investigation of micturition
26.7
10.6
14
6
L04AX01
ATC
azathioprine; systemic
13.4
10.6
18
16
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
13.3
10.0
17
15
UKC02
NOMESCO Finland
Cystoscopy
5.2
9.7
23
54
M03BX01
ATC
baclofen; systemic
20.0
9.7
14
8
N07XX09
ATC
[U] dimethyl fumarate
+∞
9.5
9
*
F02.89*G35
ICD-10 Finland
Dementia in multiple sclerosis
+∞
9.5
9
*
L28
ICPC
Limited function/disability (L)
4.5
9.1
27
76
XKC03
NOMESCO Finland
Water cystometry
16.3
8.5
13
9
H48.1*G35
ICD-10 Finland
Retrobulbar neuritis in multiple sclerosis
+∞
8.4
8
*
A28
ICPC
Limited function/disability NOS
4.8
8.3
21
52
R1250
NOMESCO Finland
Evaluation of functional capability
11.4
7.8
14
14
XCK10
NOMESCO Finland
Photography of fundus of eye
5.0
7.6
18
42
N99
ICPC
Neurological disease other
86.1
7.5
8
*
WW400
NOMESCO Finland
Plasmaferesis
+∞
7.4
7
*
G36.9
ICD-10 Finland
Acute disseminated demyelination, unspecified
+∞
7.4
7
*
N06BA07
ATC
modafinil; oral
+∞
7.4
7
*
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
21.9
7.3
10
5
A02BC02
ATC
pantoprazole; systemic
3.9
7.1
83
541
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
18.3
6.9
10
6
ZXA10
NOMESCO Finland
Bilateral
3.6
6.9
28
98
J01EA01
ATC
trimethoprim; systemic
3.1
6.9
43
196
G04BD08
ATC
solifenacin; oral
7.8
6.8
15
22
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
24.4
6.8
9
*
G04BD09
ATC
trospium; oral
24.4
6.8
9
*
R20.2
ICD-10 Finland
Paraesthesia of skin
4.3
6.7
19
51
Z3231
NOMESCO Finland
Registered nurse
3.0
6.7
42
191
H53.1
ICD-10 Finland
Subjective visual disturbances
4.7
6.4
16
39
N39.4
ICD-10 Finland
Other specified urinary incontinence
4.7
6.4
16
39
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
6.3
6
*
L04AX07
ATC
dimethyl fumarate; oral
+∞
6.3
6
*
L04AE01
ATC
fingolimod; oral
+∞
6.3
6
*
L04AK02
ATC
teriflunomide; oral
+∞
6.3
6
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.7
6.2
23
75
R5110, ,
SPAT
8.1
6.1
13
18
Z71.8
ICD-10 Finland
Other specified counselling
2.8
6.0
46
231
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
23
11
26.49
16.91
1.3
1.2
—
—
—
0
0
46
145
4.96
14.12
4.7
2.4
5.83
10.86
e6/l
0.42
38
126
60
237
4.72
13.70
8.2
2.7
—
—
—
0
0
51
193
4.28
11.99
7.5
2.6
0.12
0.29
e6/l
0.77
42
138
13
5
29.41
10.09
7.7
3.2
—
—
—
0
0
71
383
3.81
9.20
7.8
3.9
0.00
0.00
estimate
-0.00
22
78
70
379
3.70
8.92
6.3
3.0
0.00
0.00
estimate
-0.00
21
81
71
390
3.70
8.80
6.2
3.0
0.00
0.00
estimate
-0.00
21
72
12
6
22.37
8.70
1.1
1.0
—
—
—
0
0
30
104
3.67
7.53
7.3
2.3
4.53
2.56
e6/l
0.46
19
51
61
339
2.99
6.78
3.4
2.2
95.59
72.42
nmol/l
5.07
55
309
31
117
3.37
6.77
7.0
2.2
1.00
0.94
e6/l
0.04
19
63
41
207
2.64
5.15
7.7
3.2
0.00
0.00
estimate
-0.00
22
78
9
11
8.84
4.66
1.0
1.3
—
—
—
0
0
9
11
8.84
4.66
1.0
1.3
—
—
—
0
0
12
23
5.76
4.62
1.8
2.0
—
—
—
0
0
51
298
2.42
4.60
9.3
10.9
1.14
1.17
inr
0.12
19
89
8
10
8.56
4.14
1.0
1.2
—
—
—
0
0
49
298
2.24
3.86
6.9
2.9
—
—
—
0
0
6
5
12.62
3.81
1.0
1.0
—
—
—
0
0
11
25
4.80
3.75
1.5
1.3
—
—
—
0
0
9
19
5.09
3.32
6.7
4.6
2.80
3.47
g/l
—
9
19
12
37
3.54
3.05
3.8
1.8
—
—
—
0
0
5
5
10.42
3.01
1.0
1.8
—
—
—
0
0
6
9
7.00
2.91
1.0
1.0
—
—
—
0
0
32
187
2.04
2.62
1.9
1.9
0.68
0.92
mg/l
0.69
21
146
5
7
7.43
2.57
1.0
1.6
2.18
1.92
mmol/l
—
5
7
9
30
3.19
2.21
1.3
1.4
—
—
—
0
0
12
49
2.64
2.19
2.3
1.2
—
—
—
0
0
16
78
2.25
2.04
14.4
7.2
104.88
104.01
mmol/l
0.33
16
78
6
16
3.91
1.96
2.0
1.6
—
—
—
0
0
20
109
2.04
1.94
1.8
1.5
—
—
—
0
0
9
35
2.72
1.85
1.3
1.2
—
—
—
0
0
7
23
3.19
1.83
3.6
4.2
206.86
160.04
%
—
7
23
48
352
1.69
1.80
10.5
6.0
1.22
1.22
mmol/l
0.27
41
306
7
25
2.93
1.68
1.7
3.1
—
—
—
0
0
7
25
2.93
1.68
3.1
3.5
101.29
99.36
%
—
7
25
6
20
3.12
1.60
2.5
1.4
—
—
—
0
0
38
271
1.64
1.54
2.2
3.2
48.86
26.79
ng/l
0.28
21
152
7
28
2.61
1.48
1.7
1.3
—
—
—
0
0
7
28
2.61
1.48
1.7
1.3
—
—
—
0
0
11
53
2.21
1.44
22.6
3.7
5.93
5.85
kpa
0.11
11
53
5
118
0.39
1.35
2.4
1.7
—
—
—
0
0
8
34
2.47
1.32
2.0
1.3
—
—
—
0
0
14
78
1.92
1.29
1.9
2.0
259.64
355.06
nmol/l
1.07
14
72
94
869
2.04
1.27
24.8
11.0
13.40
19.72
mg/l
1.46
78
662
6
25
2.48
1.26
28.2
5.0
24.50
24.69
mmol/l
—
6
25
8
37
2.26
1.24
2.6
2.4
—
—
—
0
0
11
57
2.04
1.22
2.5
2.9
—
—
—
0
0
13
72
1.92
1.21
1.8
1.3
—
—
—
0
0
96
899
2.15
1.14
27.7
12.2
64.40
70.10
umol/l
3.00
96
899
19
122
1.68
1.12
3.2
2.8
2.46
2.44
mmol/l
0.18
19
106
77
677
1.56
1.11
5.2
4.3
14.61
14.43
pmol/l
0.29
70
634
10
52
2.02
1.10
1.6
1.3
—
—
—
0
0
5
21
2.45
1.10
2.4
1.8
—
—
—
0
0
7
34
2.13
1.05
12.7
2.3
2.04
1.33
%
—
7
34
13
76
1.81
1.04
1.8
1.3
—
—
—
0
0
21
143
1.59
1.00
1.4
1.8
—
—
—
0
0
19
128
1.60
0.94
1.4
1.7
—
—
—
0
0
18
120
1.61
0.93
4.4
3.2
18.50
309.68
ng/l
—
8
77
29
217
1.47
0.91
1.4
1.3
0.74
1.13
u/ml
—
9
71
47
386
1.40
0.89
3.6
2.3
—
—
—
0
0
8
46
1.80
0.85
1.0
1.0
—
—
—
0
0
6
33
1.87
0.80
1.0
1.3
—
2.74
—
0
7
30
232
1.42
0.79
2.6
2.3
51.30
53.92
u/l
0.28
30
216
12
75
1.68
0.79
4.9
1.6
—
—
—
0
0
74
667
1.40
0.75
3.5
3.7
—
—
—
0
0
25
191
1.41
0.70
4.3
1.8
—
—
—
0
0
5
27
1.89
0.69
1.2
1.2
—
56.50
—
0
5
86
800
1.48
0.68
23.8
9.7
95.00
87.86
ml/min/173m2
3.95
77
659
7
44
1.63
0.66
1.6
1.5
—
—
—
0
0
5
29
1.76
0.64
1.6
1.9
—
—
—
0
0
8
49
1.69
0.64
4.3
8.3
116.50
123.27
g/l
—
8
49
5
30
1.70
0.62
15.8
2.5
24.62
24.74
mmol/l
—
5
30
0
23
0.00
0.59
0.0
1.2
—
1.69
—
0
15
9
59
1.58
0.57
5.7
1.6
—
—
—
0
0
33
278
1.28
0.49
2.8
1.9
91.68
97.62
pmol/l
0.36
19
148
8
56
1.46
0.44
6.6
3.4
59.56
73.31
ng/l
—
8
51
5
33
1.54
0.42
4.0
1.9
0.21
0.24
g/l
—
5
33
5
33
1.54
0.42
2.4
4.8
3.34
0.52
mmol/l
—
5
28
77
811
0.79
0.39
4.1
3.6
1.30
1.25
mmol/l
0.29
70
758
5
36
1.41
0.39
7.8
5.5
24.80
25.03
mmol/l
—
5
36
11
82
1.38
0.36
1.1
1.4
39.82
26.49
iu/l
0.60
11
71
81
843
0.81
0.30
4.0
4.0
1.50
1.54
mmol/l
0.24
74
795
83
859
0.82
0.26
4.2
4.3
2.81
2.88
mmol/l
0.29
76
811
7
92
0.74
0.23
19.0
6.4
—
—
—
0
0
7
92
0.74
0.23
4.1
4.3
31.43
33.58
%
—
7
60
8
100
0.78
0.22
1.6
1.6
1.46
1.28
%
—
8
91
84
813
1.19
0.21
6.4
4.7
1.71
1.73
mu/l
0.06
79
754
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
7.96
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
2.8
—
156.39
—
0
7
7
57
1.24
0.19
1.4
1.4
—
—
—
0
0
5
66
0.75
0.17
1.4
1.4
—
—
—
0
0
12
101
1.21
0.17
2.9
4.3
1.24
1.64
ug/l
0.33
12
80
6
78
0.75
0.16
6.8
3.9
6.82
5.37
ug/l
—
6
61
20
181
1.13
0.13
1.2
1.3
14.08
18.68
iu/ml
—
6
63
26
240
1.11
0.13
1.5
1.5
—
—
—
0
0
20
182
1.12
0.12
1.3
1.3
1.29
6.38
u/ml
—
8
76
5
43
1.17
0.10
2.0
1.3
—
—
—
0
0
24
232
1.05
0.02
1.8
1.6
—
—
—
0
0
24
235
1.03
0.00
1.7
1.7
1.27
1.36
mmol/l
0.31
19
207
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
11.10
—
0
6
0
5
0.00
-0.00
0.0
1.8
—
11.74
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
56.20
—
0
5
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: G6_NMO – Neuromyelitis optica
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).