No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
205 |
4. Check minimum number of eventsNone |
205 |
5. Include endpointsNone |
205 |
6. Filter based on genotype QC (FinnGen only) |
205 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L70
- Name in latin
- Acne conglobata
Similar endpoints
↥List of similar endpoints to
Acne conglobata
based on the number of shared cases.
Similar with more cases:
- Acne
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2189 | 621 | 1555 |
| Only index persons | 2136 | 611 | 1525 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.02 | 0.04 |
| Only index persons | 0.05 | 0.02 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 21.34 | 25.74 | 19.47 |
| Only index persons | 21.13 | 25.47 | 19.39 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 205 | 92 | 113 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | 28.84 | 30.71 | 27.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 183
- Matched controls
- 1829
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L70.1
ICD-10 Finland
Acne conglobata
+∞
250.5
178
*
D10BA01
ATC
isotretinoin; oral
29.3
78.2
117
104
L70.0
ICD-10 Finland
Acne vulgaris
55.5
64.7
76
23
J01AA07
ATC
tetracycline; systemic
12.8
49.0
105
174
J01AA04
ATC
lymecycline; systemic
7.4
26.9
74
153
L73.2
ICD-10 Finland
Hidradenitis suppurativa
68.4
25.8
29
5
L70.9
ICD-10 Finland
Acne, unspecified
42.0
15.7
19
5
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
11.0
13.8
26
27
L72.1
ICD-10 Finland
Trichilemmal cyst
11.8
13.2
24
23
L70
ICD-10 Finland
Acne
11.3
12.4
23
23
J01FF01
ATC
clindamycin; systemic
3.7
12.4
65
239
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
7.6
10.8
25
37
S10
ICPC
Boil/carbuncle
7.5
10.3
24
36
L70.8
ICD-10 Finland
Other acne
42.6
10.1
12
*
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
16.2
9.7
15
10
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
9.5
9.6
19
22
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
11.6
9.5
17
16
D10AX03
ATC
azelaic acid; topical
4.3
9.4
36
99
H02AB06
ATC
prednisolone; systemic
2.6
8.5
83
443
E0001A1
ATC
NA
8.0
7.9
17
23
N05BA04
ATC
oxazepam; oral
3.0
7.8
49
197
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
7.0
7.6
18
28
L02.0
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of face
10.0
7.4
14
15
E0000UV
ATC
NA
2.4
7.3
86
495
J01DB01
ATC
cefalexin; oral
2.9
7.1
155
1207
TQW99
NOMESCO Finland
Other minor procedure on skin
8.3
6.7
14
18
L02.8
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of other sites
12.9
6.7
11
9
S96
ICPC
Acne
7.9
6.5
14
19
L71.0
ICD-10 Finland
Perioral dermatitis
18.8
6.3
9
5
380
Kela drug reimbursment
Adalimumab (hidradenitis suppurativa)
+∞
6.3
6
*
7061E
ICD-9 Finland
Diseases of sebaceous glands, Other acne[ACNE CONGLOBATA]
+∞
6.3
6
*
P01AB01
ATC
metronidazole; oral, rectal
2.3
6.2
67
364
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
126
874
2.15
6.47
13.5
8.9
4.2
4.1
e9/l
0.23
117
773
107
754
1.88
4.68
5.0
5.3
6.6
6.5
mmol/l
0.06
94
680
84
550
1.89
4.60
8.9
6.7
1.2
1.2
mmol/l
0.66
71
463
185
1604
2.57
4.12
16.1
10.0
20.8
21.0
mg/l
0.03
153
1189
28
127
2.40
3.99
4.7
2.9
3729.6
4081.3
u/l
—
10
59
55
327
1.93
3.95
2.0
1.6
1.4
1.4
mmol/l
0.26
50
284
65
413
1.84
3.79
2.1
1.6
92.0
96.4
pmol/l
0.40
45
215
55
333
1.89
3.72
2.1
2.1
186.4
239.9
u/l
0.25
50
322
74
492
1.79
3.71
3.6
3.0
28.2
29.9
u/l
0.34
69
466
17
63
2.85
3.59
1.4
2.0
39.0
38.6
u/l
0.04
17
56
94
693
1.66
3.13
2.9
2.5
100.2
83.6
ug/l
0.49
86
642
49
302
1.82
3.10
2.3
2.0
2.9
2.8
mg/l
0.16
44
253
35
193
1.98
3.09
3.3
2.4
1.4
0.8
e6/l
0.88
16
100
133
1077
1.67
3.02
5.2
3.3
12.6
8.2
mm/h
2.34
127
994
131
1057
1.66
3.02
9.3
6.3
75.3
75.7
u/l
0.05
125
985
13
46
2.95
2.98
2.1
2.3
—
—
—
0
0
33
186
1.92
2.73
3.4
2.6
3.8
3.3
e6/l
0.09
14
95
7
15
4.79
2.62
1.0
1.3
—
—
—
0
0
12
45
2.77
2.50
2.0
2.0
—
—
—
0
0
8
22
3.74
2.39
1.4
1.3
—
—
—
0
0
8
22
3.74
2.39
1.4
1.3
—
—
—
0
0
5
8
6.37
2.38
1.4
1.3
—
—
—
0
0
20
100
2.11
2.30
18.3
14.1
1.0
1.1
inr
—
6
18
7
18
3.99
2.27
6.7
1.5
—
—
—
0
0
11
42
2.71
2.22
8.7
2.2
53.5
47.2
%
0.32
11
42
30
177
1.81
2.17
1.6
2.6
2.4
2.4
mmol/l
0.07
25
160
57
402
1.58
2.14
3.1
2.9
16.5
32.6
ng/l
0.79
23
205
36
227
1.71
2.09
1.5
1.4
20.5
19.6
nmol/l
0.12
36
198
5
10
5.09
2.08
1.2
1.0
—
—
—
0
0
5
10
5.09
2.08
1.8
1.3
2.0
1.7
mmol/l
—
5
10
12
50
2.49
2.06
2.7
2.4
—
—
—
0
0
16
77
2.17
2.02
8.0
3.0
1.2
1.2
mmol/l
0.17
16
66
43
290
1.61
1.94
3.1
1.7
1.3
1.4
%
0.29
38
268
7
23
3.11
1.81
1.3
1.7
—
—
—
0
0
30
188
1.70
1.79
2.0
1.8
—
—
—
0
0
8
32
2.56
1.61
1.0
1.1
—
—
—
0
0
163
1474
1.52
1.61
4.5
3.2
1.4
1.4
mmol/l
0.97
156
1371
5
15
3.39
1.53
1.4
1.4
—
—
—
0
0
5
15
3.39
1.53
1.4
1.5
—
—
—
0
0
7
27
2.65
1.53
1.1
1.3
—
—
—
0
0
5
16
3.18
1.44
1.4
1.9
—
—
—
0
0
6
22
2.78
1.44
1.5
1.5
—
—
—
0
0
17
96
1.84
1.44
4.9
3.8
2.4
1.9
mmol/l
0.47
11
76
59
453
1.42
1.44
1.5
1.3
0.6
2.1
u/ml
0.74
14
103
164
1498
1.47
1.41
4.8
3.4
2.7
2.8
mmol/l
1.37
158
1388
7
29
2.46
1.40
2.0
2.1
—
—
—
0
0
156
1413
1.44
1.39
13.9
8.7
98.9
96.9
ml/min/173m2
0.46
130
1086
19
113
1.75
1.37
7.1
14.4
0.0
1.2
mmol/l
0.53
14
88
5
17
2.99
1.36
1.4
1.8
—
—
—
0
0
5
17
2.99
1.36
1.4
1.8
—
—
—
0
0
5
17
2.99
1.36
1.2
1.1
—
—
—
0
0
25
161
1.63
1.36
2.2
2.5
4.6
9.2
umol/l
1.03
20
137
10
49
2.09
1.24
1.1
1.2
—
—
—
0
0
46
349
1.41
1.19
4.0
2.5
0.3
0.3
e6/l
0.05
33
248
7
31
2.30
1.11
1.0
1.1
—
—
—
0
0
37
276
1.42
1.05
2.4
2.1
—
—
—
0
0
63
513
1.33
1.05
1.9
1.7
—
—
—
0
0
11
60
1.88
1.05
1.4
1.5
—
—
—
0
0
54
432
1.34
1.01
2.4
2.2
—
—
—
0
0
12
70
1.76
0.95
4.5
6.7
25.4
24.8
mmol/l
0.33
12
70
40
310
1.36
0.92
3.4
2.5
347.2
3058.5
umol/l
0.79
32
281
6
29
2.10
0.90
1.2
1.0
—
—
—
0
0
6
29
2.10
0.90
2.2
1.7
—
—
—
0
0
14
89
1.62
0.83
5.4
1.7
—
—
—
0
0
137
1259
1.27
0.83
6.3
3.9
39.0
37.8
mmol/mol
0.66
130
1181
33
253
1.36
0.82
1.5
1.5
—
—
—
0
0
54
450
1.27
0.75
5.0
2.7
—
—
—
0
0
6
106
0.55
0.75
1.3
1.5
—
—
—
0
0
10
62
1.64
0.66
2.3
1.7
—
—
—
0
0
79
697
1.22
0.66
4.0
2.9
0.0
0.0
estimate
0.00
15
140
28
219
1.32
0.63
2.9
3.1
8.1
686.4
ng/l
0.74
15
135
17
123
1.42
0.60
1.0
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
79
705
1.20
0.57
4.0
3.0
0.0
0.0
estimate
0.00
16
140
44
370
1.24
0.57
4.5
3.3
0.0
0.0
estimate
0.50
15
138
62
541
1.21
0.57
4.2
2.9
—
—
—
0
0
73
649
1.19
0.55
4.0
4.0
—
—
—
0
0
6
38
1.60
0.55
1.3
1.9
1345.0
167.7
e6/l
—
6
31
6
98
0.60
0.53
1.5
1.4
—
—
—
0
0
78
700
1.18
0.53
5.5
4.1
0.0
0.0
estimate
0.00
16
147
54
477
1.18
0.44
2.6
2.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
15
193
0.76
0.41
1.4
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
12
88
1.39
0.41
1.9
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.5
—
—
—
0
0
10
71
1.43
0.40
1.9
1.3
—
—
—
0
0
16
125
1.30
0.38
1.0
1.2
—
—
—
0
0
27
227
1.22
0.37
2.7
2.0
—
—
—
0
0
29
246
1.21
0.36
1.3
1.3
6.5
6.3
u/ml
0.01
12
101
16
126
1.29
0.36
2.0
1.6
—
—
—
0
0
6
45
1.34
0.34
1.0
4.1
160.8
164.8
%
—
6
45
7
98
0.70
0.31
1.4
1.4
—
—
—
0
0
7
98
0.70
0.31
1.4
1.4
—
—
—
0
0
35
308
1.16
0.30
2.5
2.2
—
—
—
0
0
7
56
1.26
0.29
1.6
1.5
—
—
—
0
0
7
56
1.26
0.29
1.4
1.3
—
—
—
0
0
7
56
1.26
0.29
1.0
1.1
—
5.1
—
0
8
16
130
1.25
0.29
2.1
1.7
—
—
—
0
0
16
130
1.25
0.29
5.5
2.0
30.5
30.6
u/l
0.01
16
105
18
214
0.83
0.27
1.6
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
13
108
1.22
0.20
1.8
2.0
—
—
—
0
0
0
14
0.00
0.20
0.0
3.1
—
96.3
—
0
14
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
15
127
1.20
0.20
1.2
1.3
13.4
109.6
iu/ml
—
5
51
9
78
1.16
0.15
1.2
1.5
—
—
—
0
0
5
44
1.14
0.10
1.4
1.3
—
—
—
0
0
24
257
0.93
0.09
1.4
1.3
11.4
20.6
iu/ml
—
5
80
6
54
1.11
0.09
1.0
1.1
—
—
—
0
0
6
55
1.09
0.09
1.0
1.1
—
—
—
0
0
5
61
0.82
0.08
1.2
2.1
—
—
—
0
0
6
73
0.82
0.07
2.3
1.5
—
—
—
0
0
25
265
0.94
0.07
2.7
3.4
25.7
21.8
%
—
9
96
9
87
1.04
0.07
1.4
1.8
—
—
—
0
0
162
1634
0.96
0.05
16.0
10.5
41.1
41.5
%
0.33
134
1367
146
1470
0.98
0.02
3.6
3.7
—
—
—
0
0
12
119
1.01
0.00
6.8
5.2
—
—
—
0
0
140
1405
0.99
0.00
4.7
3.1
5.8
5.7
mmol/l
0.57
133
1286
10
95
1.06
0.00
1.5
1.4
—
—
—
0
0
32
318
1.01
0.00
1.9
2.1
0.6
0.8
mg/l
0.95
26
233
12
115
1.05
0.00
6.3
2.8
—
—
—
0
0
19
192
0.99
0.00
2.5
2.4
0.7
0.7
ug/l
0.08
12
98
0
5
0.00
0.00
0.0
3.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
71.2
—
0
8
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
121.2
—
0
5
0
5
0.00
0.00
0.0
3.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
15.7
—
0
5
9
98
0.91
0.00
1.3
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
7
69
1.01
0.00
1.4
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
9
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
247.9
—
0
6
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
22.7
—
0
7
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
143.7
—
0
6
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
8
0.00
0.00
0.0
2.4
—
111.6
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
0.3
—
0
9
Mortality – FinRegistry
↥Association
Association between endpoint L12_ACNE_CONGLOBLATA and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACNE_CONGLOBLATA | 2.188 [1.59, 3.01] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 1137 males with L12_ACNE_CONGLOBLATA died.
Mortality risk
Mortality risk for people of age
years, who have L12_ACNE_CONGLOBLATA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.376% |
| 5 | No data | 2.552% |
| 10 | No data | 6.73% |
| 15 | No data | 12.466% |
| 20 | No data | 21.196% |
Relationships between endpoints
↥Index endpoint: L12_ACNE_CONGLOBLATA – Acne conglobata
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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