≡ Risteys
R13

Documentation Changelog GitHub Contact & Feedback

Acne conglobata

MESH Endpoint Browser PheWeb

L12_ACNE_CONGLOBLATA

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L70.1
  • Hospital discharge: ICD-9 — 7061E
  • Cause of death: ICD-10 — L70.1
  • Cause of death: ICD-9 — 7061E

2 out of 7 registries used, show all original rules.

210

4. Check minimum number of events

None

210

5. Include endpoints

None

210

6. Filter based on genotype QC (FinnGen only)

200

Control definitions (FinnGen only)

Control exclude
L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L70
Name in latin
Acne conglobata

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2189 621 1555
Only index persons 2136 611 1525
Unadjusted period prevalence (%)
Whole population 0.04 0.02 0.04
Only index persons 0.05 0.02 0.06
Median age at first event (years)
Whole population 21.34 25.74 19.47
Only index persons 21.13 25.47 19.39

-FinnGen-

Key figures

All Female Male
Number of individuals 200 92 108
Unadjusted period prevalence (%) 0.04 0.03 0.05
Median age at first event (years) 29.04 31.05 27.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
210
Matched controls
2100
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L70.1
ICD-10 Finland
Acne conglobata
4503599627370496.0
287.2
205
*
D10BA01
ATC
isotretinoin; oral
34.9
159.3
143
121
L70.0
ICD-10 Finland
Acne vulgaris
51.4
147.8
93
32
J01AA07
ATC
tetracycline; systemic
12.7
79.5
118
192
J01AA04
ATC
lymecycline; systemic
8.6
51.3
91
172
L73.2
ICD-10 Finland
Hidradenitis suppurativa
144.0
34.9
36
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
10.8
25.9
30
32
L72.1
ICD-10 Finland
Trichilemmal cyst
11.0
24.7
28
29
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
9.2
21.0
27
33
L70
ICD-10 Finland
Acne
8.6
20.5
28
37
L70.9
ICD-10 Finland
Acne, unspecified
25.6
18.2
25
11
S10
ICPC
Boil/carbuncle
6.7
18.0
31
53
D10AX03
ATC
azelaic acid; topical
5.0
17.7
43
102
L02.0
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of face
23.2
15.0
21
10
L70.8
ICD-10 Finland
Other acne
86.3
14.8
16
*
J01FF01
ATC
clindamycin; systemic
3.2
13.6
74
305
S96
ICPC
Acne
13.7
11.9
20
16
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
5.5
11.8
24
48
E0000UV, ,
ATC
2.7
11.3
109
601
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
6.2
11.2
20
35
G03HB01
ATC
cyproterone and estrogen; oral
3.6
10.2
37
117
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
10.3
10.0
19
20
E0001A1, ,
ATC
9.8
9.8
19
21
ZYC01
NOMESCO Finland
Remote contact by phone
4.5
9.7
25
61
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
5.4
9.3
19
38
P01AB01
ATC
metronidazole; oral, rectal
2.5
9.1
85
450
380
Kela drug reimbursment
Adalimumab (hidradenitis suppurativa)
+∞
8.4
8
*
N05BA04
ATC
oxazepam; oral
2.6
8.4
60
279
H02AB06
ATC
prednisolone; systemic
2.3
7.8
95
557
XQ848
NOMESCO Finland
Dermatological photography
8.7
6.9
14
17
L02.8
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of other sites
9.8
6.9
13
14
K59.1
ICD-10 Finland
Functional diarrhoea
6.3
6.8
17
29
J01DA01
ATC
[U] cefalexin
2.1
6.5
126
869
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
6.3
76
436
7061E
ICD-9 Finland
Diseases of sebaceous glands, Other acne[ACNE CONGLOBATA]
+∞
6.3
6
*
J04AB02
ATC
rifampicin; systemic
27.6
6.3
8
*
A02BC02
ATC
pantoprazole; systemic
2.1
6.2
119
812
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.8
6.2
19
53
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.2
6.1
26
90
TQW99
NOMESCO Finland
Other minor procedure on skin
5.9
6.1
16
29

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
122
786
2.32
8.11
10.3
5.9
0.60
0.54
e9/l
1.94
113
700
126
827
2.31
7.96
10.2
5.9
2.01
1.94
e9/l
0.48
119
753
40
154
2.97
7.93
1.9
1.5
—
—
—
0
0
120
786
2.23
7.43
10.5
5.9
0.04
0.04
e9/l
0.80
112
699
40
162
2.81
7.21
3.5
2.0
—
—
—
0
0
122
811
2.20
7.20
10.5
6.5
0.17
0.18
e9/l
0.22
114
733
130
908
2.13
6.50
13.2
8.9
4.13
4.04
e9/l
0.18
120
802
111
744
2.04
6.05
12.0
6.5
—
—
—
0
0
78
485
1.97
5.04
5.3
4.6
36.52
37.52
g/l
0.86
73
461
41
200
2.30
4.97
1.2
1.5
400.00
520.00
titre
—
10
42
110
778
1.87
4.73
4.9
5.3
6.52
6.49
mmol/l
0.02
97
699
86
564
1.89
4.67
8.8
6.9
1.21
1.21
mmol/l
0.54
73
483
30
133
2.46
4.48
4.8
2.9
3108.21
5886.60
u/l
0.31
12
64
190
1650
2.59
4.19
15.8
10.0
20.63
21.14
mg/l
0.09
156
1220
56
330
1.95
4.12
2.0
1.6
1.41
1.36
mmol/l
0.19
51
287
12
28
4.48
3.88
1.7
2.9
—
—
—
0
0
7
8
9.00
3.80
1.1
1.1
—
—
—
0
0
56
339
1.89
3.78
2.1
2.1
183.80
232.54
u/l
0.23
51
328
58
356
1.87
3.75
10.4
6.6
—
—
—
0
0
66
422
1.82
3.75
2.1
1.6
91.72
96.23
pmol/l
0.42
46
219
54
336
1.82
3.31
5.2
2.9
7.40
7.40
ph
0.20
13
58
135
1085
1.68
3.20
9.1
6.3
75.81
76.12
u/l
0.04
129
1012
47
283
1.85
3.19
2.4
2.5
142.63
131.99
ug/g
0.08
36
214
14
50
2.93
3.15
2.4
3.7
0.64
0.16
g/l
—
8
30
97
722
1.64
3.07
2.8
2.5
98.40
82.13
ug/l
0.49
89
672
17
69
2.59
3.04
2.6
1.3
—
—
—
0
0
7
12
5.99
3.04
6.7
1.4
—
—
—
0
0
21
95
2.35
3.01
1.0
1.1
—
—
—
0
0
136
1105
1.65
3.00
5.2
3.4
12.54
8.23
mm/h
2.33
130
1021
70
489
1.65
2.80
9.0
8.0
1.01
1.12
inr
3.18
26
166
34
192
1.92
2.80
3.4
2.7
3.79
3.46
e6/l
0.05
14
100
21
100
2.22
2.69
5.7
5.0
0.59
0.72
%
0.14
11
36
49
315
1.72
2.66
2.3
2.0
2.87
2.78
mg/l
0.13
44
266
21
102
2.18
2.57
6.6
5.6
0.10
0.09
%
—
10
33
141
1181
1.59
2.53
4.3
3.5
14.69
14.56
pmol/l
0.25
136
1079
22
110
2.12
2.51
6.4
5.4
1.27
0.95
%
0.20
11
42
7
16
4.49
2.49
6.0
2.5
5.17
7.03
mmol/l
—
7
16
24
125
2.04
2.47
7.3
7.7
103.96
104.05
mmol/l
0.02
24
125
59
410
1.61
2.37
2.4
1.3
2.90
2.13
g/l
1.40
37
242
90
692
1.53
2.31
15.6
8.6
0.00
0.00
e9/l
-0.00
76
559
58
404
1.60
2.30
3.1
2.9
16.46
32.50
ng/l
0.79
23
206
21
107
2.07
2.30
1.3
1.3
—
—
—
0
0
7
18
3.98
2.27
6.0
2.3
1.16
1.36
mmol/l
—
7
18
30
179
1.79
2.09
1.6
2.6
2.42
2.42
mmol/l
0.07
25
161
5
10
5.09
2.08
1.8
1.3
1.96
1.72
mmol/l
—
5
10
19
97
2.05
2.08
7.1
5.8
0.00
0.14
%
—
8
29
36
228
1.70
2.05
1.5
1.4
20.52
19.45
nmol/l
0.15
36
199
27
157
1.83
2.05
1.1
1.3
—
—
—
0
0
16
77
2.17
2.02
8.0
3.1
1.22
1.22
mmol/l
0.21
16
66
9
33
2.80
1.95
1.3
3.5
25.76
24.48
mmol/l
—
9
33
33
207
1.70
1.95
1.5
1.5
—
—
—
0
0
42
286
1.59
1.81
4.5
4.2
—
—
—
0
0
8
29
2.83
1.81
1.1
1.2
—
—
—
0
0
55
400
1.51
1.77
3.7
2.8
138.62
205.98
e6/l
0.13
42
300
64
482
1.47
1.74
4.1
3.3
404.83
65.39
e6/l
0.42
45
318
63
474
1.47
1.72
1.5
1.3
0.66
2.00
u/ml
0.73
16
110
10
42
2.45
1.64
7.3
2.0
—
—
—
0
0
5
14
3.63
1.62
1.4
1.2
—
—
—
0
0
44
311
1.52
1.62
3.8
3.0
—
—
—
0
0
18
100
1.88
1.59
5.8
10.8
—
—
—
0
0
9
37
2.50
1.50
2.0
1.7
3.05
0.77
ug/l
—
9
32
165
1500
1.47
1.47
4.5
3.2
1.36
1.41
mmol/l
0.74
159
1403
6
22
2.78
1.44
1.3
2.5
—
—
—
0
0
11
53
2.13
1.41
1.1
1.2
166.20
228.27
u/ml
—
5
30
12
60
2.06
1.41
7.3
21.5
—
—
—
0
0
40
286
1.49
1.39
4.9
3.7
6.09
16.69
mg/mmol
2.04
30
185
48
360
1.43
1.32
3.9
2.6
0.29
0.33
e6/l
0.11
34
258
25
163
1.61
1.30
2.2
2.8
4.55
9.12
umol/l
1.04
20
139
41
299
1.46
1.30
4.6
2.9
—
—
—
0
0
76
618
1.36
1.30
2.2
2.1
—
—
—
0
0
166
1526
1.42
1.25
4.8
3.4
2.69
2.84
mmol/l
1.49
160
1422
6
25
2.44
1.25
4.0
2.6
—
—
—
0
0
5
19
2.67
1.22
1.8
1.1
—
—
—
0
0
6
26
2.34
1.19
4.0
3.5
—
—
—
0
0
22
144
1.59
1.14
1.8
1.5
—
—
—
0
0
18
273
0.63
1.08
1.2
1.3
—
—
—
0
0
42
320
1.39
1.06
2.0
1.6
—
—
—
0
0
7
34
2.09
1.04
4.1
3.8
5.33
3.76
e9/l
—
7
34
7
34
2.09
1.04
4.4
3.9
58.43
55.68
%
—
7
34
45
351
1.36
0.99
4.6
2.7
1.02
1.02
kg/l
—
9
40
9
50
1.84
0.98
1.6
1.1
—
—
—
0
0
0
31
0.00
0.97
0.0
1.2
—
—
—
0
0
21
143
1.52
0.94
1.4
1.4
—
—
—
0
0
6
28
2.18
0.92
1.2
2.5
—
—
—
0
0
14
87
1.65
0.90
1.0
1.3
—
—
—
0
0
6
29
2.10
0.90
3.5
2.9
—
—
—
0
0
6
30
2.03
0.87
1.0
1.0
—
—
—
0
0
35
268
1.37
0.87
4.0
3.3
42.20
106.19
mg/l
1.54
30
184
10
57
1.79
0.85
4.7
2.7
—
—
—
0
0
40
315
1.33
0.83
3.4
2.7
347.19
4129.45
umol/l
1.07
32
288
0
24
0.00
0.79
0.0
2.9
—
—
—
0
0
0
24
0.00
0.79
0.0
5.8
—
—
—
0
0
0
24
0.00
0.79
0.0
5.4
—
—
—
0
0
6
33
1.84
0.79
2.0
1.6
—
—
—
0
0
43
346
1.31
0.78
3.7
2.5
—
—
—
0
0
139
1286
1.24
0.74
6.2
3.9
38.90
37.92
mmol/mol
0.57
132
1208
7
39
1.82
0.73
1.3
1.5
—
—
—
0
0
5
25
2.02
0.73
4.0
2.7
5.80
5.00
kpa
—
5
25
5
25
2.02
0.73
4.0
2.7
8.46
9.12
kpa
—
5
25
21
152
1.42
0.72
1.4
1.2
—
—
—
0
0
12
180
0.65
0.71
2.3
1.9
—
—
—
0
0
63
539
1.24
0.70
2.5
1.8
—
—
—
0
0
82
723
1.22
0.69
4.0
3.0
0.00
0.00
estimate
-0.00
16
152
12
78
1.57
0.67
4.5
7.4
25.36
24.71
mmol/l
0.35
12
78
14
95
1.51
0.66
7.6
3.9
—
—
—
0
0
111
1013
1.20
0.64
4.8
3.7
—
—
—
0
0
46
384
1.25
0.63
4.3
3.3
0.00
0.01
estimate
0.50
15
143
82
730
1.20
0.61
3.9
3.0
0.00
0.00
estimate
-0.00
16
145
183
1760
1.31
0.61
14.4
8.9
—
—
—
0
0
0
21
0.00
0.60
0.0
4.4
—
68.11
—
0
21
8
52
1.56
0.60
5.3
3.1
0.76
0.70
%
—
8
52
8
52
1.56
0.60
1.0
1.3
—
—
—
0
0
28
222
1.30
0.57
2.9
2.9
8.13
761.34
ng/l
0.87
15
138
81
725
1.19
0.56
5.3
4.1
0.00
0.00
estimate
-0.00
16
152
14
99
1.44
0.55
1.3
1.2
—
—
—
0
0
6
40
1.51
0.52
1.3
2.3
1345.00
157.58
e6/l
—
6
33
6
40
1.51
0.52
1.0
2.1
3.17
7.97
e6/l
—
6
32
17
129
1.35
0.47
1.2
1.3
14.33
110.27
iu/ml
—
6
52
7
48
1.47
0.47
2.3
1.7
0.21
0.23
g/l
—
7
48
17
130
1.33
0.45
5.2
2.0
30.65
30.83
u/l
0.01
17
104
6
92
0.64
0.43
1.2
1.7
—
—
—
0
0
5
32
1.58
0.42
1.2
1.0
—
—
—
0
0
8
59
1.37
0.41
2.1
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
10
71
1.43
0.40
1.6
1.7
—
—
—
0
0
5
35
1.44
0.39
1.0
1.1
—
—
—
0
0
29
341
0.83
0.38
1.8
1.5
—
—
—
0
0
30
254
1.21
0.38
1.3
1.3
6.11
7.05
u/ml
0.06
13
105
22
181
1.24
0.36
1.4
1.4
—
—
—
0
0
54
485
1.15
0.36
1.9
1.7
—
—
—
0
0
48
428
1.16
0.35
2.5
2.2
—
—
—
0
0
6
44
1.37
0.34
12.5
5.5
—
—
—
0
0
13
100
1.32
0.34
2.2
2.1
—
25.19
—
0
7
19
156
1.24
0.32
4.5
2.0
—
—
—
0
0
45
403
1.15
0.31
2.0
1.8
—
—
—
0
0
66
611
1.12
0.28
2.8
2.1
—
—
—
0
0
8
65
1.24
0.27
3.3
3.1
—
—
—
0
0
13
158
0.81
0.24
1.1
1.3
—
—
—
0
0
195
1922
1.20
0.23
24.6
14.7
41.22
41.35
%
0.13
187
1815
10
79
1.28
0.22
1.1
1.2
—
—
—
0
0
17
144
1.20
0.22
6.7
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
0.31
—
0
6
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
6.2
—
12.38
—
0
13
0
14
0.00
0.20
0.0
1.1
—
0.20
—
0
9
19
165
1.17
0.20
1.2
1.1
—
—
—
0
0
11
91
1.22
0.18
6.4
2.4
—
—
—
0
0
7
61
1.15
0.17
2.9
1.6
—
—
—
0
0
97
934
1.07
0.16
2.8
2.8
—
—
—
0
0
22
197
1.13
0.16
4.0
1.9
—
—
—
0
0
22
198
1.12
0.15
4.0
1.9
—
—
—
0
0
7
88
0.79
0.15
3.9
2.1
—
—
—
0
0
7
88
0.79
0.15
1.0
1.1
—
—
—
0
0
59
560
1.07
0.15
1.5
1.6
—
—
—
0
0
21
189
1.12
0.14
4.1
1.9
—
—
—
0
0
39
365
1.08
0.13
4.2
2.5
—
—
—
0
0
5
47
1.07
0.09
1.2
2.0
—
—
—
0
0
21
196
1.08
0.07
4.1
1.9
—
—
—
0
0
21
196
1.08
0.07
3.3
1.9
—
—
—
0
0
43
440
0.97
0.03
3.3
2.6
—
—
—
0
0
10
93
1.08
0.02
1.3
1.4
—
—
—
0
0
26
266
0.97
0.00
1.3
1.3
11.38
20.43
iu/ml
—
5
82
32
326
0.98
0.00
1.9
2.3
0.60
0.84
mg/l
0.98
26
239
144
1435
1.01
0.00
4.6
3.1
5.79
5.67
mmol/l
0.52
136
1313
10
98
1.02
0.00
7.9
2.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
-0.00
1.7
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
1.54
—
0
8
6
61
0.98
-0.00
1.3
1.1
—
—
—
0
0
19
190
1.00
-0.00
2.5
2.4
0.71
0.67
ug/l
0.08
12
96
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
14
140
1.00
-0.00
4.6
3.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
10.6
—
—
—
0
0
6
68
0.88
-0.00
8.0
11.0
—
—
—
0
0
6
59
1.02
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
7.27
—
0
7
0
8
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_ACNE_CONGLOBLATA and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
L12_ACNE_CONGLOBLATA 2.188 [1.59, 3.01] < 0.001
Birth year 0.99 [0.98, 1.0] 0.035

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 1137 males with L12_ACNE_CONGLOBLATA died.

Mortality risk

Mortality risk for people of age

years, who have L12_ACNE_CONGLOBLATA.

N-year risk Females Males
1 No data 0.376%
5 No data 2.552%
10 No data 6.73%
15 No data 12.466%
20 No data 21.196%

Relationships between endpoints

↥

Index endpoint: L12_ACNE_CONGLOBLATA – Acne conglobata

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data