Acquired keratosis [keratoderma] palmaris et plantaris

L12_ACQKERAT

skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L85.1 Hospital discharge: ICD-9 — 7011A\|7011E\|7011D Hospital discharge: ICD-8 — 70110 Cause of death: ICD-10 — L85.1 Cause of death: ICD-9 — 7011A\|7011E\|7011D Cause of death: ICD-8 — 70110 2 out of 7 registries used, show all original rules.	155
4. Check minimum number of events None	155
5. Include endpoints None	155
6. Filter based on genotype QC (FinnGen only)	155

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L85
Name in latin: Keratosis (keratoderma) palmaris et plantaris acquisita

NAME	L12_ACQKERAT
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L851
HD_ICD_9	7011A\|7011E\|7011D
HD_ICD_8	70110
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L851
COD_ICD_9	7011A\|7011E\|7011D
COD_ICD_8	70110
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Acquired keratosis [keratoderma] palmaris et plantaris based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1124	601	516
Only index persons	982	536	446
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	54.60	57.17	51.70
Only index persons	54.36	56.87	51.33

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	155	83	72
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	55.64	57.10	53.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
142: Matched controls
1418

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L85.1

ICD-10 Finland

Acquired keratosis [keratoderma] palmaris et plantaris

7981.1

160.2

123

D07XC01

ATC

betamethasone, combinations; topical

19.6

46.8

D05BB02

ATC

acitretin; oral

72.2

40.5

E0000UV

ATC

8.9

31.1

105

344

D02AE01

ATC

carbamide; topical

15.8

26.0

D07AC01

ATC

betamethasone; topical

5.5

20.3

308

D07AD01

ATC

clobetasol; topical

6.7

19.2

125

L30.9

ICD-10 Finland

Dermatitis, unspecified

6.5

18.4

126

D07AC13

ATC

mometasone; topical

4.5

14.9

259

XQ802

NOMESCO Finland

Epicutan test

16.9

14.7

E000003

ATC

12.9

14.2

D05AX02

ATC

calcipotriol; topical

12.2

12.8

7011A

ICD-9 Finland

Other hypertrophic and atrophic conditions of skin, Keratoderma, acquired[KERATODERMA PALMARE ET PLANTARE ACQUISITUM]

+∞

11.6

E000001

ATC

4.3

11.4

156

L85.9

ICD-10 Finland

Epidermal thickening, unspecified

+∞

10.5

L30.8

ICD-10 Finland

Other specified dermatitis

20.7

10.5

E000006

ATC

7.2

9.9

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

5.2

9.1

D07BC01

ATC

betamethasone and antiseptics; topical

4.5

8.7

TQW80

NOMESCO Finland

Local dermatologic skincare

13.9

8.6

70110

ICD-8 Finland

Other hypertrophic and atrophic conditions of the skin, Keratoderma acquisitum (Kämmen, jalkapohja) (palmare, plantare)

+∞

7.3

D07XB01

ATC

flumetasone, combinations; topical

42.1

6.8

D05AX52

ATC

calcipotriol, combinations; topical

5.7

6.6

L30.3

ICD-10 Finland

Infective dermatitis

11.8

6.4

L40.0

ICD-10 Finland

Psoriasis vulgaris

6.8

6.4

D09AB01

ATC

zinc bandage without supplements; topical

19.0

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3000494) Fungus identified in Specimen by Culture

159

4.29

15.09

2.1

1.5

—

(40768443) Skin Pathology biopsy report

5.24

9.62

1.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.84

8.43

2.7

2.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

4.67

7.72

2.7

1.8

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

245

2.46

5.92

4.3

3.6

974.8

185.4

ng/l

0.58

181

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

189

2.10

3.37

2.9

1.9

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

10.27

3.00

1.2

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

160

2.08

2.97

2.2

2.3

24.1

22.2

0.26

139

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

353

1.76

2.69

2.6

3.0

530.6

990.2

ng/l

2.52

300

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

7.33

2.56

1.2

1.0

—

(3032080) INR in Blood by Coagulation assay

492

1.68

2.53

6.3

7.3

1.2

inr

0.16

130

(3019150) Specific gravity of Urine by Refractometry

258

1.80

2.50

2.5

3.9

1.0

kg/l

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

5.15

2.42

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

4.41

2.17

1.2

1.1

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

277

1.71

2.16

2.0

1.6

0.9

1.2

mg/l

0.53

219

(3013115) Eosinophils [#/volume] in Blood

653

1.58

2.10

9.1

5.8

0.2

e9/l

0.64

573

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

5.12

2.08

1.6

1.1

—

(3035637) Corticotropin [Mass/volume] in Plasma

5.12

2.08

2.4

1.1

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

280

1.69

2.07

2.7

2.0

1.9

3.2

mg/l

5.51

245

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

2.17

1.99

3.8

2.9

5.7

5.1

kpa

1.15

(3037467) Urinalysis macro (dipstick) panel - Urine

103

859

1.59

1.98

5.7

4.0

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.67

1.96

1.9

1.4

1.2

g/l

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

4.66

1.95

1.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

194

1.75

1.91

1.4

1.9

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

3.28

1.90

2.4

1.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

3.28

1.90

2.4

1.4

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

3.28

1.90

2.4

1.4

—

(3006315) Basophils [#/volume] in Blood

634

1.54

1.90

8.9

5.7

0.0

e9/l

0.88

549

(3019225) pH of Specimen

117

1.92

1.85

4.1

4.8

—

(42870588) Differential panel, method unspecified - Blood

430

1.56

1.84

10.0

5.2

—

(3023368) Bacteria identified in Blood by Culture

319

1.58

1.72

4.3

4.1

—

(3019198) Lymphocytes [#/volume] in Blood

653

1.50

1.72

8.6

5.6

1.8

1.9

e9/l

0.49

576

(4034850)

0.00

1.72

0.0

9.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

3.65

1.63

1.0

1.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

506

1.49

1.61

2.2

1.9

84.1

94.6

pmol/l

0.75

252

(3019060) Gas panel - Arterial blood

2.02

1.60

5.3

4.6

—

(3001604) Monocytes [#/volume] in Blood

631

1.48

1.59

8.9

5.6

0.6

e9/l

0.38

544

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

585

1.47

1.55

4.1

3.7

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.52

1.50

2.1

1.4

0.2

g/l

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.31

1.50

4.6

2.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

311

1.53

1.49

3.0

2.3

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.39

1.45

2.2

1.6

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

2.79

1.45

2.7

1.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

738

1.45

1.44

10.5

9.8

4.2

4.0

e9/l

0.50

647

(3013707) Erythrocyte sedimentation rate by Westergren method

108

942

1.48

1.43

6.3

4.1

16.1

12.0

mm/h

1.75

103

864

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.16

1.42

1.4

2.2

41.0

39.8

u/l

0.06

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

2.67

1.38

2.7

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

2.67

1.38

2.7

1.3

—

(3004616) Nuclear Ab [Presence] in Serum

3.00

1.37

1.2

1.3

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.89

1.37

2.7

1.7

2.1

1.6

g/l

0.20

(3044640) Blood type and Crossmatch panel - Blood

399

1.46

1.35

2.6

2.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

1.35

0.0

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

1.35

0.0

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

1.35

0.0

1.2

—

(3009343) pH of Capillary blood

1.87

1.26

4.1

2.9

—

7.4

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.45

1.25

2.8

5.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

142

1.64

1.22

2.1

1.5

—

(3012516) Albumin [Mass/volume] in Urine

369

1.44

1.22

3.5

3.1

52.1

239.4

mg/l

0.51

228

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.78

1.16

2.1

1.4

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

2.03

1.14

3.5

3.6

25.1

24.9

mmol/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

393

1.40

1.12

4.0

3.9

7.8

10.1

mg/mmol

0.20

235

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

2.32

1.12

1.0

—

3.3

—

(1761868) Lipid panel - Serum or Plasma

480

0.70

1.09

2.5

2.9

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

137

1280

1.61

1.08

18.2

13.3

26.8

22.3

mg/l

0.77

115

991

(3022217) INR in Platelet poor plasma by Coagulation assay

156

1.56

1.06

10.9

20.4

1.3

inr

0.05

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

2.11

1.04

1.1

1.3

—

3.2

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.31

1.04

1.0

1.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

608

1.34

1.02

12.1

6.6

1.2

mmol/l

0.17

518

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

2.05

1.01

1.1

1.3

—

1.9

—

(40768804) Tissue Pathology biopsy report

522

1.35

1.01

2.1

—

(40758558) Short blood count panel - Blood

333

0.67

1.00

8.0

6.9

—

(3023419) Bacteria identified in Sputum by Culture

2.21

0.99

3.4

2.4

—

(3009508) Creatinine [Moles/volume] in Urine

401

1.36

0.98

3.5

2.9

7.4

7.9

mmol/l

0.29

336

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

160

1.51

0.96

1.4

1.6

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.93

0.95

1.3

1.9

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.93

0.95

2.6

1.3

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.27

0.94

1.0

1.2

—

(3022313) Gas panel - Capillary blood

1.87

0.94

4.3

3.3

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

2.19

0.92

1.0

1.6

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.04

0.88

5.8

2.1

—

(3017732) Neutrophils [#/volume] in Blood

1.65

0.88

2.3

2.5

4.6

3.9

e9/l

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

505

1.31

0.84

2.7

2.2

80.9

77.2

nmol/l

0.49

447

(3003694) ABO and Rh group [Type] in Blood

338

1.33

0.80

1.1

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

229

1.38

0.79

1.4

1.5

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

110

0.53

0.75

66.2

6.6

1.1

1.3

mmol/l

—

104

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.67

0.75

7.0

2.9

26.3

25.0

mmol/l

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

524

1.27

0.71

5.2

4.2

35.6

35.7

g/l

0.03

496

(4035726)

116

0.58

0.71

1.3

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.74

0.71

1.0

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

307

1.32

0.70

2.4

3.7

0.0

estimate

0.00

101

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

1.88

0.69

1.0

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

103

945

1.27

0.68

4.2

3.8

14.4

14.7

pmol/l

0.71

856

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.66

0.67

2.4

2.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.75

0.64

2.0

1.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.69

0.62

6.8

2.0

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

1.69

0.62

2.0

1.2

10.2

8.8

u/l

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.69

0.62

1.4

1.7

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.60

0.60

1.6

3.7

4.5

pmol/l

—

(3042936) Bacteria identified in Isolate by Culture

186

1.34

0.59

3.1

1.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.49

0.57

1.2

1.6

—

(36304419) Bacteria [Presence] in Urine

356

0.77

0.57

3.4

2.9

—

(3047169) Lambda light chains.free [Mass/volume] in Serum or Plasma

1.69

0.57

4.2

18.2

24.3

mg/l

—

(3034860) Kappa light chains.free [Mass/volume] in Serum

1.69

0.57

4.2

98.8

257.4

mg/l

—

(3035350) Ketones [Presence] in Urine by Test strip

614

1.22

0.57

2.7

3.3

0.0

estimate

0.00

106

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

336

1.26

0.55

3.6

4.6

29.2

21.2

1.25

152

(4010399)

100

1.44

0.54

2.1

1.5

—

(3003396) Base excess in Arterial blood by calculation

144

1.36

0.54

22.2

7.3

1.9

1.3

mmol/l

0.47

116

(3019309) Folate [Moles/volume] in Red Blood Cells

227

1.28

0.51

1.5

1.7

866.2

1148.3

nmol/l

1.07

167

(3026008) Bacteria identified in Urine by Culture

349

1.24

0.51

4.8

2.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

621

1.20

0.49

3.7

4.6

0.0

estimate

0.00

109

(3021589) Normoblasts [#/volume] in Blood

555

0.83

0.47

9.0

8.9

0.0

e9/l

0.54

432

(3007164) IgA [Mass/volume] in Serum or Plasma

260

1.24

0.44

1.7

1.4

2.9

2.5

g/l

1.04

159

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.63

0.43

1.4

1.5

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

1.63

0.43

4.6

1.7

4.3

3.9

g/l

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.63

0.43

1.4

1.5

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.53

0.41

1.2

2.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

133

1283

1.26

0.40

5.3

4.5

1.4

1.5

mmol/l

1.35

127

1187

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.40

0.0

1.1

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.40

0.0

1.1

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

158

0.74

0.39

37.3

6.5

104.7

104.1

mmol/l

0.20

152

(3028271) Lactate [Moles/volume] in Capillary blood

0.00

0.39

0.0

1.8

—

1.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

114

0.69

0.38

2.5

3.4

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.40

0.38

3.8

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

144

1.28

0.37

1.2

1.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.28

0.37

1.4

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

468

1.17

0.36

2.6

3.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

109

1.31

0.35

2.0

1.9

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.35

0.34

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

628

1.15

0.33

2.6

3.3

0.0

estimate

0.00

101

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.29

0.32

1.5

1.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

129

1.27

0.32

1.3

1.5

—

(3013512) EKG study

376

1.16

0.31

3.8

4.0

—

(3021960) Folate [Moles/volume] in Serum or Plasma

290

1.18

0.30

1.7

1.5

22.5

21.8

nmol/l

0.09

243

(3009542) Hematocrit [Volume Fraction] of Blood

114

1183

0.86

0.30

21.0

14.0

40.5

40.6

0.03

890

(3008898) HLA-B27 [Presence]

1.26

0.30

1.0

1.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

161

0.79

0.28

4.5

7.4

—

(40761511) CBC panel - Blood by Automated count

132

1353

0.84

0.28

15.9

12.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.30

0.27

1.1

1.8

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.20

0.27

42.4

9.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.27

0.26

1.7

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

133

1.23

0.25

3.3

1.8

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.27

0.25

1.8

2.8

84.7

69.3

ml/min/173m2

—

(3000492) Spirometry study

126

0.78

0.25

1.8

1.4

—

(3030467) Casts [#/volume] in Urine by Automated count

357

0.87

0.25

2.6

3.0

0.3

0.4

e6/l

0.34

256

(3022621) pH of Urine by Test strip

1.18

0.25

3.6

1.9

—

(40768797) Stomach Pathology biopsy report

181

1.19

0.24

1.1

1.2

—

(3034770) Mitochondria Ab [Titer] in Serum

1.36

0.24

1.2

1.1

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

125

1215

1.15

0.24

6.3

5.5

40.4

39.8

mmol/mol

0.27

119

1140

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

220

0.84

0.23

1.9

2.7

2.9

0.9

e6/l

—

121

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

209

0.84

0.22

2.1

2.9

8.7

2.3

e6/l

—

112

(3051651) Icteric interference index of Serum or Plasma

0.00

0.21

0.0

2.4

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

1.1

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.21

0.0

10.1

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

15.5

—

914.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.21

0.0

1.6

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

573

1.11

0.21

10.5

5.7

1.2

mmol/l

0.13

521

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.20

0.0

4.4

—

118.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

118

1.20

0.20

2.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

137

1.19

0.19

3.4

1.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

493

0.90

0.19

3.3

3.6

1665.1

34.5

ng/l

0.49

333

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

796

1.09

0.18

3.2

2.8

—

(36660697) Celiac disease serology panel - Serum

101

1.20

0.17

1.2

1.1

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.76

0.16

57.5

9.2

94.2

—

(21494755) Public health laboratory ask at order entry panel

129

0.84

0.15

1.5

1.4

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.80

0.15

1.3

1.4

—

39.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.20

0.14

2.9

1.9

—

(3026782) Osmolality of Urine

252

0.90

0.14

2.4

2.7

493.3

556.5

mosm/kgh2o

0.65

205

(3044889) 12 lead EKG panel

907

0.93

0.13

4.4

3.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

446

1.08

0.12

4.1

3.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

339

1.08

0.11

2.8

2.9

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

212

1.10

0.11

1.3

3.8

6.7

u/ml

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

125

0.87

0.10

2.2

1.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

284

1.07

0.08

1.5

1.2

1.3

0.7

u/ml

—

(3022145) Colonoscopy Study observation

133

0.89

0.08

1.7

1.3

—

(3002256) Pathology report gross observation

170

0.93

0.04

1.1

1.2

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

128

1269

1.05

0.04

6.0

4.6

6.0

mmol/l

0.24

120

1173

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

220

1.05

0.04

1.5

1.3

30.1

30.6

iu/ml

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

192

1.05

0.02

1.8

1.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

288

0.97

0.02

2.3

3.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

283

1.03

0.01

4.1

5.1

—

(3002582) Erythrocytes [#/volume] in Urine

397

0.98

0.01

3.5

3.1

61.1

193.5

e6/l

0.36

298

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

106

0.94

0.01

1.5

1.4

—

(3000991) Gas panel - Venous blood

106

0.94

0.01

40.0

8.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

123

1226

1.02

0.00

16.6

12.7

85.4

81.4

ml/min/173m2

1.20

997

(3018095) Leukocytes [#/volume] in Urine

459

1.00

0.00

4.0

3.7

199.4

53.6

e6/l

0.49

322

(3004451) EKG impression Narrative

0.00

0.0

1.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.02

0.00

2.5

1.3

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

1.8

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

67.5

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

1.7

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(40761536) Microorganisms panel - Urine sediment

0.97

0.00

1.9

3.3

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.3

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.7

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.7

—

(40761535) Cells panel - Urine sediment

1.00

0.00

2.1

3.6

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.3

—

(42868415) European tick borne encephalitis virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

0.0

3.3

—

(4024509)

0.00

0.0

1.3

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.90

0.00

1.5

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.0

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.2

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

6.6

—

202.8

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.0

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

0.0

1.5

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.3

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.6

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.8

—

(1002224) Polysomnography panel

1.00

0.00

1.0

1.1

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3022192) Triglyceride [Mass/volume] in Serum or Plasma

0.00

0.0

4.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay

0.00

0.0

1.0

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.2

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3038769) Chlamydophila pneumoniae IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

22.0

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

1.3

—

12.7

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

1.8

—

8.5

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

30.5

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.2

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.4

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

1.7

—

13.1

—

(4027681)

0.00

-0.00

0.0

1.1

—

(4211845)

0.00

-0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_ACQKERAT and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_ACQKERAT	1.483 [1.05, 2.09]	0.025
Birth year	0.991 [0.98, 1.0]	0.053

During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 400 females with L12_ACQKERAT died.

Males

Parameter	HR [95% CI]	p-value
L12_ACQKERAT	1.494 [1.12, 2.0]	0.007
Birth year	0.987 [0.98, 1.0]	0.011

During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 297 males with L12_ACQKERAT died.

Mortality risk

Mortality risk for people of age

years, who have L12_ACQKERAT.

N-year risk	Females	Males
1	0.085%	0.303%
5	0.719%	1.604%
10	1.966%	4.021%
15	3.781%	7.835%
20	6.415%	13.288%

Relationships between endpoints

↥

Index endpoint: L12_ACQKERAT – Acquired keratosis [keratoderma] palmaris et plantaris

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Acquired keratosis [keratoderma] palmaris et plantaris

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints