Transient acantholytic dermatosis [Grover]

L12_GROVER

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L11.1 Cause of death: ICD-10 — L11.1 2 out of 7 registries used, show all original rules.	57
4. Check minimum number of events None	57
5. Include endpoints None	57
6. Filter based on genotype QC (FinnGen only)	57

Control definitions (FinnGen only)

Control exclude: L12_BULLOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L11
Name in latin: Dermatosis acantholytica transitoria

NAME	L12_GROVER
CONTROL_EXCLUDE	L12_BULLOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L111
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L111
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Transient acantholytic dermatosis [Grover] based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	277	60	216
Only index persons	264	57	207
Unadjusted period prevalence (%)
Whole population	0.01	0.00	0.01
Only index persons	0.01	0.00	0.01
Median age at first event (years)
Whole population	74.29	72.41	74.76
Only index persons	74.06	72.09	74.61

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	57	11	46
Unadjusted period prevalence (%)	0.02	0.00	0.02
Median age at first event (years)	73.26	70.85	73.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
51: Matched controls
509

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L11.1

ICD-10 Finland

Transient acantholytic dermatosis [Grover]

+∞

73.0

D05BB02

ATC

acitretin; oral

247.9

17.7

L30.9

ICD-10 Finland

Dermatitis, unspecified

14.1

15.7

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

12.8

13.5

E0000UV

ATC

10.2

12.8

123

D07AC01

ATC

betamethasone; topical

6.5

9.1

120

D07AB02

ATC

hydrocortisone butyrate; topical

5.9

8.2

D07AC13

ATC

mometasone; topical

5.5

7.5

XQ845

NOMESCO Finland

Dermatoscopy

46.4

7.0

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

6.4

6.8

E000001

ATC

5.7

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

27.47

25.94

2.0

1.0

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.91

3.90

1.2

2.3

—

(3022145) Colonoscopy Study observation

3.34

3.48

1.7

1.3

—

(3020630) Protein [Mass/volume] in Serum or Plasma

3.39

3.37

1.3

2.4

66.3

65.9

g/l

0.08

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

121

2.70

3.17

2.3

1.6

1.1

1.3

mmol/l

0.48

104

(3002256) Pathology report gross observation

3.05

2.87

1.5

1.3

—

(42870588) Differential panel, method unspecified - Blood

167

2.50

2.86

7.9

5.3

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

8.97

2.80

1.0

1.7

0.2

0.3

g/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

213

2.48

2.77

2.4

2.2

91.0

89.2

pmol/l

0.09

123

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

6.55

2.77

1.2

1.6

—

(40760888) Immunoglobulin light chains.free panel - Serum

6.55

2.77

1.2

5.2

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

172

2.40

2.63

2.3

2.6

91.9

74.3

nmol/l

1.87

151

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

7.68

2.60

1.0

1.7

1.2

g/l

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

6.71

2.42

1.4

1.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

5.02

2.33

1.3

—

(3008898) HLA-B27 [Presence]

5.96

2.26

1.0

1.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

266

2.29

2.21

4.2

6.1

11.2

13.4

umol/l

0.89

256

(40768804) Tissue Pathology biopsy report

174

2.20

2.18

3.1

2.3

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

5.36

2.11

1.2

—

(3049717) Cytology report of Urine Cyto stain

3.41

2.10

3.6

3.3

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

4.34

2.10

1.5

—

(40768797) Stomach Pathology biopsy report

2.43

2.03

1.7

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.27

2.02

1.3

2.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

2.40

1.89

1.9

1.4

2.1

2.5

g/l

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.60

1.80

1.7

1.9

—

(3032080) INR in Blood by Coagulation assay

240

2.03

1.79

8.6

11.2

1.4

inr

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.83

1.73

1.7

2.4

9.4

10.5

g/l

—

(40761536) Microorganisms panel - Urine sediment

2.61

1.71

4.6

4.2

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

171

1.96

1.64

3.3

0.6

0.8

ug/l

0.63

118

(3018418) pH of Serum or Plasma

145

1.98

1.63

3.1

4.7

7.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

251

1.88

1.47

4.7

8.0

1.2

mmol/l

3.18

212

(40760892) CBC W Ordered Manual Differential panel - Blood

2.01

1.35

4.1

4.9

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

236

1.81

1.35

4.1

4.8

21.2

21.7

0.09

124

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

434

2.24

1.32

4.9

1.5

1.4

mmol/l

1.18

386

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

447

2.34

1.24

5.1

5.4

6.1

6.3

mmol/l

0.36

399

(3037467) Urinalysis macro (dipstick) panel - Urine

321

1.83

1.22

6.0

4.9

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

194

1.74

1.21

2.1

3.6

795.9

1644.2

ng/l

1.45

163

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

438

2.15

1.18

6.3

5.0

4.3

mmol/l

0.01

396

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

439

2.13

1.18

6.0

7.2

40.3

42.1

mmol/mol

0.80

406

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.18

1.11

1.2

1.4

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

311

1.67

0.97

6.4

5.5

2.1

ug/l

0.06

268

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

222

1.62

0.97

4.0

4.1

—

(3028026) IgM [Mass/volume] in Serum or Plasma

2.27

0.95

1.3

1.5

4.0

0.9

g/l

—

(36660697) Celiac disease serology panel - Serum

2.27

0.95

1.3

1.2

—

(4035726)

2.05

0.93

1.3

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.98

0.84

1.8

1.7

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

429

1.75

0.84

23.5

17.8

74.5

72.8

ml/min/173m2

0.25

363

(40761511) CBC panel - Blood by Automated count

464

1.94

0.83

19.4

18.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

219

1.55

0.82

2.5

2.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.69

0.82

1.8

1.9

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.79

0.79

2.2

2.6

5.1

12.8

umol/l

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

164

1.56

0.79

2.4

2.1

168.6

211.7

u/l

0.24

154

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

451

1.88

0.79

5.8

5.6

2.3

2.5

mmol/l

0.80

407

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

194

1.51

0.74

4.3

3.6

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

420

1.68

0.70

5.7

4.5

1.1

1.3

mmol/l

2.25

370

(40758558) Short blood count panel - Blood

114

1.56

0.68

8.8

6.5

—

(3044889) 12 lead EKG panel

326

1.50

0.67

4.4

4.7

—

(36304419) Bacteria [Presence] in Urine

142

1.51

0.66

4.9

3.4

—

(3019225) pH of Specimen

1.73

0.65

2.6

4.6

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.65

0.65

5.9

3.7

—

(3009542) Hematocrit [Volume Fraction] of Blood

360

1.49

0.62

23.4

20.1

38.0

39.5

0.27

224

(3000494) Fungus identified in Specimen by Culture

1.62

0.59

1.3

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.54

0.57

2.0

1.8

—

(3013512) EKG study

168

1.40

0.50

3.8

4.8

—

(1761868) Lipid panel - Serum or Plasma

133

1.40

0.45

2.9

3.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

115

1.41

0.45

4.0

2.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.67

0.44

1.0

1.4

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.62

0.43

1.0

1.7

2.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.62

0.43

1.4

—

(3023368) Bacteria identified in Blood by Culture

172

1.35

0.43

4.9

5.0

—

(3003694) ABO and Rh group [Type] in Blood

107

1.41

0.42

1.4

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.46

0.41

2.0

1.8

—

(3026008) Bacteria identified in Urine by Culture

147

1.33

0.37

5.4

3.5

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.41

0.36

3.2

1.9

71.7

218.2

ng/l

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

243

1.21

0.23

3.4

4.4

22.5

60.8

ng/l

1.87

196

(3041096) Erythrocytes [Presence] in Urine by Automated

137

1.23

0.22

3.7

4.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.21

0.0

1.5

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

3.6

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.21

0.0

1.7

—

234.8

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.21

0.0

1.7

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.2

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.2

—

(3012516) Albumin [Mass/volume] in Urine

167

1.21

0.20

2.6

3.3

4986.9

80.3

mg/l

—

119

(3035350) Ketones [Presence] in Urine by Test strip

246

1.19

0.20

3.1

4.2

0.0

estimate

—

(3012544) pH of Venous blood

1.19

0.18

4.9

—

(3022948) Iron [Moles/volume] in Serum or Plasma

113

1.19

0.14

1.8

2.6

13.2

10.7

umol/l

0.57

101

(3003338) MCHC [Mass/volume]

337

0.88

0.11

29.9

25.0

330.1

331.6

g/l

0.37

337

(3021601) Nitrite [Presence] in Urine by Test strip

244

1.12

0.10

4.3

5.7

0.0

estimate

—

(3044640) Blood type and Crossmatch panel - Blood

165

1.13

0.10

2.3

2.4

—

(40761535) Cells panel - Urine sediment

1.15

0.10

1.2

3.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

175

1.13

0.10

3.5

4.1

43.1

11.5

mg/mmol

—

122

(3029937) Albumin [Presence] in Urine by Test strip

147

1.12

0.08

3.4

4.2

0.0

estimate

—

(3009508) Creatinine [Moles/volume] in Urine

167

1.11

0.08

2.6

3.3

6.0

7.6

mmol/l

0.93

140

(3011397) Hemoglobin [Presence] in Urine by Test strip

112

0.87

0.08

2.0

3.8

—

(3009261) Glucose [Presence] in Urine by Test strip

249

1.08

0.05

3.3

4.3

0.0

estimate

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

102

1.10

0.03

1.7

2.6

2.0

2.2

g/l

0.41

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

194

0.97

0.00

3.5

4.5

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

1.02

0.00

1.5

1.9

33.3

29.3

—

(44790049)

0.00

0.0

1.4

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.8

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.7

—

9.6

—

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

0.00

0.0

8.4

—

12.5

—

(44790048)

0.00

0.0

1.4

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.2

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

2.2

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

4.0

—

3.6

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

16.2

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(44806118)

0.00

0.0

1.4

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.3

—

(44790047)

0.00

0.0

1.4

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.5

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.8

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

5.4

—

(3042936) Bacteria identified in Isolate by Culture

1.03

0.00

2.9

1.8

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

5.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

0.96

0.00

1.6

1.5

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

2.1

—

12.1

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

3.6

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

0.0

1.0

—

17.3

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

1.4

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

0.83

0.00

4.0

1.8

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

0.0

2.0

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

5.0

—

58.2

—

(4024509)

0.00

0.0

1.4

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_GROVER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_GROVER.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_GROVER – Transient acantholytic dermatosis [Grover]

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Transient acantholytic dermatosis [Grover]

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints