Generalized pustular psoriasis

L12_PSORI_PUSTGEN

impetigo herpetiformis: An impetigo that is characterized as a form of severe pustular psoriasis occurring in pregnancy.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L40.1 Hospital discharge: ICD-9 — 6961B Hospital discharge: ICD-8 — 69610 Cause of death: ICD-10 — L40.1 Cause of death: ICD-9 — 6961B Cause of death: ICD-8 — 69610 2 out of 7 registries used, show all original rules.	133
4. Check minimum number of events None	133
5. Include endpoints None	133
6. Filter based on genotype QC (FinnGen only)	126

Control definitions (FinnGen only)

Control exclude: L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L40
Name in latin: Psoriasis pustulosa generalisata

NAME	L12_PSORI_PUSTGEN
CONTROL_EXCLUDE	L12_PAPULOSQUAMOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L401
HD_ICD_9	6961B
HD_ICD_8	69610
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L401
COD_ICD_9	6961B
COD_ICD_8	69610
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Generalized pustular psoriasis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	983	481	487
Only index persons	740	384	356
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	54.30	56.74	51.88
Only index persons	52.55	54.23	50.72

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	126	68	58
Unadjusted period prevalence (%)	0.03	0.02	0.03
Median age at first event (years)	52.42	50.72	54.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
133: Matched controls
1330

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L40.1

ICD-10 Finland

Generalized pustular psoriasis

+∞

144.4

111

D05AX52

ATC

calcipotriol, combinations; topical

81.3

113.0

L40.0

ICD-10 Finland

Psoriasis vulgaris

425.3

82.7

D07XC01

ATC

betamethasone; topical

22.6

75.2

D05AX02

ATC

calcipotriol; topical

555.3

66.9

L04AX03

ATC

methotrexate; systemic

18.8

61.7

D05BB02

ATC

acitretin; oral

208.9

60.8

D07AD01

ATC

clobetasol; topical

13.9

53.4

101

E000003, ,

ATC

24.3

46.4

E000001, ,

ATC

11.2

45.1

138

D07AC01

ATC

betamethasone; topical

14.4

44.3

108

307

L40.5

ICD-10 Finland

Arthropathic psoriasis

+∞

44.3

M07.3*L40.5

ICD-10 Finland

Other psoriatic arthropathies

+∞

40.7

E0000UV, ,

ATC

13.4

38.3

111

364

D05AX03

ATC

calcitriol; topical

419.9

33.5

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

10.1

32.9

319

Kela drug reimbursment

Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)

+∞

32.7

L40.9

ICD-10 Finland

Psoriasis, unspecified

208.5

32.3

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

9.4

32.1

A07EC01

ATC

sulfasalazine; oral, rectal

9.0

24.2

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

10.6

23.7

134

Kela drug reimbursment

General erythroderma

275.5

23.4

D07AC13

ATC

mometasone; topical

5.7

22.8

245

D07AB02

ATC

hydrocortisone butyrate; topical

5.6

22.4

242

L40.8

ICD-10 Finland

Other psoriasis

261.2

22.3

L40.3

ICD-10 Finland

Pustulosis palmaris et plantaris

130.7

21.3

L04AB04

ATC

adalimumab; parenteral

39.9

21.1

L01BA01

ATC

methotrexate; systemic

22.4

20.7

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

24.5

18.6

D07AB08

ATC

desonide; topical

6.3

18.4

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

22.7

18.2

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

7.8

16.9

E000002, ,

ATC

6.2

16.8

L04AD01

ATC

ciclosporin; systemic

30.8

16.2

TQW80

NOMESCO Finland

Local dermatologic skincare

21.7

15.3

L04AA01

ATC

[U] ciclosporin

64.4

15.2

L04AC10

ATC

secukinumab; parenteral

+∞

14.9

L30.9

ICD-10 Finland

Dermatitis, unspecified

4.4

13.5

134

6961A

ICD-9 Finland

Psoriasis and similar disorders, Other psoriasis[PSORIASIS VULGARIS]

+∞

12.7

M07.3

ICD-10 Finland

Other psoriatic arthropathies

+∞

12.7

H02AB06

ATC

prednisolone; systemic

3.7

11.9

467

L04AB01

ATC

etanercept; parenteral

25.7

11.9

L04AC05

ATC

ustekinumab; parenteral

+∞

11.6

M07.0*L40.5

ICD-10 Finland

Distal interphalangeal psoriatic arthropathy

+∞

11.6

6961B

ICD-9 Finland

Psoriasis and similar disorders, Other psoriasis[PSORIASIS PUSTULARIS]

+∞

11.6

L27.0

ICD-10 Finland

Generalized skin eruption due to drugs and medicaments

130.9

11.6

69610

ICD-8 Finland

Psoriasis and similar disorders, Psoriasis pustulosa

+∞

10.6

L40

ICD-10 Finland

Psoriasis

35.7

10.5

D07BA04

ATC

hydrocortisone and antiseptics; topical

5.1

10.0

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

4.7

9.6

L04AC13

ATC

ixekizumab; parenteral

107.3

9.5

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

4.1

9.1

D02AE01

ATC

carbamide; topical

5.2

8.9

H02AB07

ATC

prednisone; oral

3.9

8.9

WXQ27

NOMESCO Finland

UVB narrow spectrum light therapy

29.7

8.6

L04AA13

ATC

[U] leflunomide

11.9

8.5

69619

ICD-8 Finland

Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)

+∞

8.4

L04AA11

ATC

[U] etanercept

+∞

8.4

6960A

ICD-9 Finland

Psoriasis and similar disorders, Psoriatic arthropathy

+∞

8.4

D02AX

ATC

Other emollients and protectives

11.1

8.3

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

3.0

7.7

187

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

4.4

7.5

E000007, ,

ATC

6.8

7.4

D05AA

ATC

Tars

+∞

7.4

D07AA02

ATC

hydrocortisone; topical

3.3

7.2

117

E000006, ,

ATC

5.8

6.6

R60.0

ICD-10 Finland

Localized oedema

3.3

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3037522) Nuclear Ab [Titer] in Serum

128

4.64

14.44

1.3

290.00

623.53

titre

—

(40760892) CBC W Ordered Manual Differential panel - Blood

501

4.14

13.07

15.8

7.3

—

(3013115) Eosinophils [#/volume] in Blood

555

3.49

10.04

17.9

6.8

0.21

0.18

e9/l

0.66

488

(40768443) Skin Pathology biopsy report

4.99

8.20

1.6

1.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.82

6.93

1.1

1.5

—

(3002179) Metamyelocytes/100 leukocytes in Blood

3.40

6.06

5.5

4.2

0.25

0.39

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

145

2.81

5.76

1.2

1.5

—

(3021440) Promyelocytes/100 leukocytes in Blood

3.23

5.60

6.3

4.3

0.13

0.18

—

(3000475) Leukocytes [#/volume] in Synovial fluid

6.74

5.54

1.8

16138.75

21964.14

e6/l

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

11.95

5.37

1.0

—

(3023420) DNA double strand Ab [Units/volume] in Serum

10.62

5.11

1.2

1.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

121

2.79

5.08

1.2

1.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

320

2.30

5.04

3.6

3.8

14.93

6.43

mg/mmol

0.63

204

(40758558) Short blood count panel - Blood

283

2.30

4.89

13.7

8.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

553

2.26

4.89

7.2

5.5

0.00

estimate

-0.00

111

(3017181) Myelocytes/100 leukocytes in Blood

2.96

4.89

6.3

4.2

0.50

0.88

—

(3021589) Normoblasts [#/volume] in Blood

498

2.23

4.85

20.0

11.1

0.00

e9/l

0.10

402

(3021788) Differential panel - Synovial fluid

7.62

4.75

1.5

1.6

—

(3044941) Cell count panel - Synovial fluid

7.62

4.75

1.4

1.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

119

2.71

4.72

2.2

1.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

181

2.45

4.69

1.2

1.7

—

(3025159) Blasts/100 leukocytes in Blood

2.98

4.60

6.9

4.3

0.00

0.31

—

(3035350) Ketones [Presence] in Urine by Test strip

555

2.18

4.50

5.4

3.9

0.00

estimate

-0.00

119

(3009261) Glucose [Presence] in Urine by Test strip

563

2.12

4.24

5.3

3.9

0.00

estimate

-0.00

106

(3009508) Creatinine [Moles/volume] in Urine

322

2.07

3.90

3.2

3.1

7.53

7.58

mmol/l

0.02

273

(3018095) Leukocytes [#/volume] in Urine

418

2.02

3.85

6.7

4.1

134.43

42.93

e6/l

0.32

299

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

540

2.01

3.77

9.3

7.6

1.21

mmol/l

0.37

458

(3000494) Fungus identified in Specimen by Culture

128

2.39

3.61

1.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

749

2.09

3.51

7.5

4.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

250

2.06

3.51

5.6

3.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.73

3.38

1.3

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

106

2.41

3.26

4.2

3.8

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

163

2.18

3.25

1.3

1.50

9.12

u/ml

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

108

880

2.21

3.23

13.3

7.8

76.67

79.44

u/l

0.35

103

818

(3023520) Reticulocytes [#/volume] in Blood

2.50

3.12

2.6

3.5

63.82

71.74

e9/l

0.54

(3012516) Albumin [Mass/volume] in Urine

301

1.93

3.12

3.2

3.1

95.41

257.07

mg/l

0.34

191

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

260

1.97

3.10

2.8

2.0

3.35

3.08

mg/l

0.22

220

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.12

2.83

1.9

1.4

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

5.65

2.57

1.2

1.1

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

178

1.97

2.55

1.4

1.3

31.65

28.34

iu/ml

—

(3026493) Urate [Moles/volume] in Serum or Plasma

289

1.78

2.39

3.0

2.9

329.38

3694.88

umol/l

0.78

243

(3023368) Bacteria identified in Blood by Culture

316

1.75

2.35

5.5

4.7

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.90

2.34

1.2

1.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

216

1.84

2.32

1.5

1.4

3.36

2.26

g/l

1.11

121

(3026008) Bacteria identified in Urine by Culture

336

1.73

2.28

3.3

3.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.25

2.27

1.6

1.4

—

(3020779) Urea [Moles/volume] in Serum or Plasma

2.17

2.24

4.1

7.9

9.35

8.70

mmol/l

0.14

(3018418) pH of Serum or Plasma

331

1.70

2.17

5.0

3.8

7.40

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.34

2.13

1.4

1.2

—

(3002582) Erythrocytes [#/volume] in Urine

368

1.68

2.13

5.6

3.6

15.50

49.27

e6/l

1.28

282

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

281

1.72

2.11

1.8

1.7

1.48

1.39

mmol/l

0.35

227

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

436

1.63

2.02

2.6

1.9

90.60

95.59

pmol/l

0.38

228

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.29

1.96

2.0

2.6

—

(3019150) Specific gravity of Urine by Refractometry

244

1.72

1.94

5.7

4.3

1.02

1.01

kg/l

—

(3029937) Albumin [Presence] in Urine by Test strip

307

1.65

1.87

5.3

3.9

0.00

estimate

-0.00

109

(3022217) INR in Platelet poor plasma by Coagulation assay

520

1.58

1.83

15.6

12.9

1.17

1.22

inr

0.24

156

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

417

1.59

1.82

4.9

3.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.87

1.82

1.5

1.3

—

(3021960) Folate [Moles/volume] in Serum or Plasma

257

1.67

1.81

1.9

1.5

17.39

22.20

nmol/l

1.55

218

(3030467) Casts [#/volume] in Urine by Automated count

337

1.61

1.78

5.5

3.4

0.12

0.33

e6/l

1.90

253

(3016879) Cocaine [Presence] in Urine

2.77

1.75

1.1

1.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

269

1.64

1.72

2.2

2.4

1.70

1.39

mg/l

0.19

219

(3000991) Gas panel - Venous blood

2.00

1.70

8.5

8.3

—

(3052851) Hemolysis interference index of Serum or Plasma

2.68

1.69

2.4

3.0

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

3.26

1.68

3.7

2.2

4.31

4.22

e9/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

237

1.65

1.5

1.2

14.37

0.75

u/ml

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

607

1.54

1.64

6.3

7.0

12.44

11.78

umol/l

0.13

577

(3027008) Opiates [Presence] in Urine

2.59

1.62

1.1

1.5

—

(3028300) Cannabinoids [Presence] in Urine

2.59

1.62

1.1

1.5

—

(3027944) Amphetamines [Presence] in Urine

2.59

1.62

1.1

1.4

—

(3000492) Spirometry study

108

1.89

1.61

1.4

1.5

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.78

1.60

2.3

1.7

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

3.09

1.60

3.8

2.4

57.67

56.90

—

(3000764) Benzodiazepines [Presence] in Urine

2.51

1.56

1.1

1.5

—

(36304419) Bacteria [Presence] in Urine

320

1.56

1.54

5.1

3.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.68

1.53

1.4

1.1

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

2.94

1.52

2.5

1.5

—

(3045414) Leukocytes [Presence] in Urine

2.22

1.49

3.4

1.7

—

(40768804) Tissue Pathology biopsy report

453

1.50

1.45

2.2

1.9

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

2.81

1.45

1.3

1.4

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

3.20

1.45

2.2

1.7

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.49

1.41

1.3

1.5

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.28

1.40

1.6

1.2

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

2.68

1.38

1.0

2.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

429

1.48

1.37

5.4

4.1

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

3.01

1.37

1.0

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

130

1.73

1.37

2.8

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

314

1.49

1.28

4.0

3.8

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.46

1.26

1.5

1.4

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.46

1.26

1.2

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

118

1087

1.76

1.24

29.6

15.6

19.26

23.28

mg/l

1.16

108

877

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

2.69

1.22

1.2

1.1

—

(3011288) Drugs identified in Urine by Screen method

2.69

1.22

1.8

1.9

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.37

1.20

1.7

1.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

130

1.63

1.10

3.1

1.8

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.81

1.07

17.0

6.1

3.02

1.02

mmol/l

0.58

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.12

1.04

5.6

11.6

92.14

89.35

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.96

1.04

6.2

7.0

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.32

1.04

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

184

1.51

1.02

2.8

1.8

—

(3048689) Calprotectin [Mass/mass] in Stool

142

1.57

1.00

3.1

2.1

244.53

151.28

ug/g

0.49

116

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.98

0.0

1.6

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.00

0.98

2.4

1.8

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

213

1.46

0.95

5.2

3.4

1025.62

117.86

ng/l

0.46

167

(36660697) Celiac disease serology panel - Serum

1.70

0.95

1.4

1.1

—

(3022313) Gas panel - Capillary blood

1.88

0.95

21.4

6.7

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.28

0.95

1.3

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

187

1.49

0.94

1.7

1.4

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.20

0.93

1.2

1.4

—

(3042936) Bacteria identified in Isolate by Culture

162

1.51

0.92

2.2

—

(40761536) Microorganisms panel - Urine sediment

1.65

0.92

4.3

3.4

—

(3021901) Oxygen saturation in Capillary blood

2.12

0.90

7.5

2.3

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.12

0.90

2.2

3.6

211.83

193.76

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

207

1.45

0.89

4.1

2.8

0.88

0.93

e6/l

0.04

120

(3022145) Colonoscopy Study observation

121

1.56

0.88

1.7

1.3

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.83

0.86

4.6

2.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

191

1.45

0.85

4.9

3.1

1.43

1.64

e6/l

0.10

105

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

114

1064

1.50

0.85

5.2

4.6

6.08

5.93

mmol/l

0.53

107

971

(3004588) Protein electrophoresis panel - Serum or Plasma

1.71

0.85

3.4

3.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.49

0.81

1.4

1.9

—

(3045424) Erythrocytes [Presence] in Urine

2.22

0.77

1.2

1.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.71

0.76

2.0

1.9

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.58

0.76

5.7

2.9

57.43

62.74

ml/min/173m2

—

(3019060) Gas panel - Arterial blood

1.64

0.74

3.2

3.7

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.84

0.74

2.4

1.6

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.04

0.73

1.4

1.5

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

114

1072

1.44

0.73

5.9

4.5

4.51

4.65

mmol/l

0.67

109

995

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.62

0.73

2.3

4.5

24.72

24.93

mmol/l

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

109

1018

1.39

0.72

7.3

5.8

41.47

39.94

mmol/mol

0.87

102

951

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

111

1040

1.41

0.71

5.2

3.9

1.34

1.27

mmol/l

0.59

106

950

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.52

0.70

1.2

1.7

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

113

1064

1.41

0.68

5.2

4.4

1.41

1.46

mmol/l

0.80

108

977

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

669

1.28

0.67

2.6

3.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

105

0.55

0.64

1.3

1.8

—

(3014051) Protein [Presence] in Urine by Test strip

1.75

0.64

6.2

1.9

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

116

1101

1.42

0.63

6.0

5.0

2.70

2.75

mmol/l

0.22

110

1009

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.69

0.62

1.2

1.9

—

(3044889) 12 lead EKG panel

775

1.27

0.61

4.4

3.9

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.61

0.0

1.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.61

0.0

1.2

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.59

0.0

1.5

—

2.81

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.59

0.0

1.7

—

120.59

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.70

0.57

1.3

1.9

—

(3000330) Specific gravity of Urine by Test strip

1.54

0.56

4.9

5.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.51

0.55

2.8

1.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

822

1.25

0.54

4.8

4.0

14.80

14.81

pmol/l

0.01

729

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

0.60

0.54

5.0

2.7

5.25

6.36

ug/l

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

651

1.23

0.53

6.0

4.9

7.01

6.59

mmol/l

0.92

609

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

106

1001

1.29

0.52

5.4

4.6

2.14

1.93

mu/l

0.73

100

897

(3049717) Cytology report of Urine Cyto stain

1.59

0.50

1.4

2.9

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.52

0.48

1.3

2.1

—

(40768797) Stomach Pathology biopsy report

158

1.31

0.45

1.5

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

251

1.25

0.44

5.9

2.6

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

1.64

0.43

1.0

1.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.43

0.43

2.8

4.4

40.80

50.95

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

1.58

0.42

1.4

0.28

0.24

g/l

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.53

0.42

1.4

1.18

1.09

g/l

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

1.53

0.42

3.6

6.7

3.72

3.69

g/l

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.7

—

16.76

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.41

0.0

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.41

0.0

1.4

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.41

0.0

1.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.40

0.0

1.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.3

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.3

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

226

1.24

0.40

1.7

1.9

413.52

457.88

pmol/l

0.32

188

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.39

0.0

1.5

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.39

0.0

2.9

—

3.09

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.39

0.0

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.39

0.0

1.3

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.63

0.37

1.8

2.5

—

4.58

—

(3020891) Body temperature

1.48

0.36

4.5

3.7

—

(40761535) Cells panel - Urine sediment

1.33

0.33

5.3

3.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.69

0.32

1.1

1.4

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.31

0.31

2.6

3.3

0.56

0.66

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.24

0.29

2.6

3.2

1.40

1.23

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.25

0.27

2.4

4.4

132.13

131.38

g/l

—

(3013512) EKG study

323

1.16

0.26

4.5

4.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

136

0.79

0.24

14.4

7.8

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.29

0.23

1.8

1.4

—

(3008898) HLA-B27 [Presence]

1.29

0.23

1.0

1.2

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

107

1.24

0.22

3.3

2.5

0.23

0.22

g/l

0.17

100

(21494755) Public health laboratory ask at order entry panel

107

1.24

0.22

1.2

1.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.23

0.22

2.2

1.5

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.21

0.0

1.5

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

1.19

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

211.55

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

1.53

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.21

0.0

1.4

—

189.50

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

1.8

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.1

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.1

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.1

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.1

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.1

—

(3003694) ABO and Rh group [Type] in Blood

289

0.88

0.20

1.3

1.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

106

1032

1.13

0.18

27.1

14.0

82.75

80.05

ml/min/173m2

0.62

857

(3025941) Bacteria identified in Stool by Culture

1.20

0.18

1.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.73

0.17

1.6

1.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.73

0.17

1.4

1.2

—

(3022621) pH of Urine by Test strip

1.12

0.16

5.4

2.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.80

0.14

1.9

1.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

515

1.08

0.13

4.8

2.7

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

301

0.91

0.12

4.6

4.5

18.97

21.45

0.33

150

(3019225) pH of Specimen

1.16

0.10

6.9

4.9

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

114

0.87

0.10

3.4

2.6

35.80

31.52

u/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.14

0.09

1.0

1.3

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

0.85

0.08

1.3

3.3

4.61

4.58

pmol/l

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

224

0.93

0.07

2.6

3.0

0.65

0.81

ug/l

0.50

144

(3002256) Pathology report gross observation

138

1.10

0.07

1.4

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

453

0.96

0.05

5.5

4.1

27.47

40.92

ng/l

0.67

322

(3003338) MCHC [Mass/volume]

928

1.04

0.04

40.5

19.4

329.16

332.20

g/l

2.66

923

(4035726) Immunohistochemistry procedure

101

1.10

0.04

1.8

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

351

1.04

0.02

4.5

2.6

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

379

0.97

0.02

5.4

5.2

1.56

2.38

ug/l

1.73

331

(40761511) CBC panel - Blood by Automated count

114

1148

0.95

0.02

25.1

14.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

146

0.95

0.00

1.6

1.4

—

(1761868) Lipid panel - Serum or Plasma

411

1.00

0.00

3.3

2.9

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

751

1.00

0.00

3.3

2.9

57.16

45.48

u/l

0.58

706

(3009542) Hematocrit [Volume Fraction] of Blood

120

1205

0.96

0.00

43.6

22.1

40.24

40.28

0.03

113

1144

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.4

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.0

1.1

—

8.51

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

1.5

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.4

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

3.6

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

3.2

—

1.66

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

-0.00

0.0

1.8

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

1.6

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.3

—

(3006598) pH of Arterial cord blood

0.00

-0.00

0.0

1.0

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

13.33

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3021706) Oxygen [Partial pressure] in Arterial cord blood

0.00

-0.00

0.0

1.0

—

3.43

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

5.0

—

206.00

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

3.2

—

13.28

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

32.80

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(40760548) Muscle specific receptor tyrosine kinase Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.8

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.0

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.5

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3003932) Carbon dioxide [Partial pressure] in Arterial cord blood

0.00

-0.00

0.0

1.0

—

6.88

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.00

-0.00

1.4

1.5

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

-0.00

0.0

1.5

—

7.75

—

(3012741) Chlamydophila pneumoniae IgA Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.91

-0.00

5.8

3.4

16.60

204.93

u/ml

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.3

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

3.0

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(4200892) Spirometry reversibility

0.99

-0.00

1.3

1.5

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.2

—

55.33

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

-0.00

0.0

2.4

—

13.30

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.6

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(37021550) Renin [Units/volume] in Plasma --upright

0.00

-0.00

0.0

2.0

—

244.16

—

(42870560) Thyrotropin [Units/volume] in Cord blood

0.00

-0.00

0.0

1.0

—

8.91

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(3035880) pH of Pleural fluid

0.00

-0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PSORI_PUSTGEN and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_PSORI_PUSTGEN	2.109 [1.55, 2.87]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.011

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 289 females with L12_PSORI_PUSTGEN died.

Males

Parameter	HR [95% CI]	p-value
L12_PSORI_PUSTGEN	2.046 [1.29, 3.24]	0.002
Birth year	0.988 [0.98, 1.0]	0.01

During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 268 males with L12_PSORI_PUSTGEN died.

Mortality risk

Mortality risk for people of age

years, who have L12_PSORI_PUSTGEN.

N-year risk	Females	Males
1	0.185%	0.352%
5	0.897%	2.262%
10	2.342%	5.795%
15	4.631%	11.36%
20	8.298%	18.627%

Relationships between endpoints

↥

Index endpoint: L12_PSORI_PUSTGEN – Generalized pustular psoriasis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Generalized pustular psoriasis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints