Generalized pustular psoriasis

L12_PSORI_PUSTGEN

impetigo herpetiformis: An impetigo that is characterized as a form of severe pustular psoriasis occurring in pregnancy.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L40.1 Hospital discharge: ICD-9 — 6961B Hospital discharge: ICD-8 — 69610 Cause of death: ICD-10 — L40.1 Cause of death: ICD-9 — 6961B Cause of death: ICD-8 — 69610 2 out of 7 registries used, show all original rules.	129
4. Check minimum number of events None	129
5. Include endpoints None	129
6. Filter based on genotype QC (FinnGen only)	129

Control definitions (FinnGen only)

Control exclude: L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L40
Name in latin: Psoriasis pustulosa generalisata

NAME	L12_PSORI_PUSTGEN
CONTROL_EXCLUDE	L12_PAPULOSQUAMOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L401
HD_ICD_9	6961B
HD_ICD_8	69610
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L401
COD_ICD_9	6961B
COD_ICD_8	69610
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Generalized pustular psoriasis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	983	481	487
Only index persons	740	384	356
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	54.30	56.74	51.88
Only index persons	52.55	54.23	50.72

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	129	67	62
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	51.17	48.17	54.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
113: Matched controls
1128

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L40.1

ICD-10 Finland

Generalized pustular psoriasis

+∞

122.0

L40.0

ICD-10 Finland

Psoriasis vulgaris

288.9

68.8

D05AX02

ATC

calcipotriol; topical

157.6

52.3

D05BB02

ATC

acitretin; oral

158.2

47.2

D05AX52

ATC

calcipotriol, combinations; topical

57.3

45.6

D07XC01

ATC

betamethasone, combinations; topical

25.9

42.1

L40.5

ICD-10 Finland

Arthropathic psoriasis

+∞

38.8

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

21.9

33.8

D07AC01

ATC

betamethasone; topical

13.2

32.9

247

M07.3*L40.5

ICD-10 Finland

Other psoriatic arthropathies

+∞

31.8

E0000UV

ATC

12.1

30.0

299

D07AD01

ATC

clobetasol; topical

13.2

29.4

D05AX03

ATC

calcitriol; topical

350.6

28.0

E000001

ATC

10.0

26.3

134

L40.9

ICD-10 Finland

Psoriasis, unspecified

317.3

25.8

319

Kela drug reimbursment

Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)

+∞

23.8

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

13.1

20.6

134

Kela drug reimbursment

General erythroderma

+∞

20.4

E000003

ATC

18.9

20.1

L40.3

ICD-10 Finland

Pustulosis palmaris et plantaris

113.1

18.2

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

8.7

17.0

L40.8

ICD-10 Finland

Other psoriasis

198.0

17.0

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

23.0

16.9

L04AB04

ATC

adalimumab; parenteral

36.3

16.8

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

29.9

15.3

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

26.6

14.8

D07AB02

ATC

hydrocortisone butyrate; topical

5.3

14.7

194

D07AC13

ATC

mometasone; topical

4.9

14.1

223

TQW80

NOMESCO Finland

Local dermatologic skincare

20.4

13.0

D07AB08

ATC

desonide; topical

7.6

12.9

L04AD01

ATC

ciclosporin; systemic

30.7

12.4

E000002

ATC

6.2

10.9

L04AC10

ATC

secukinumab; parenteral

120.8

10.6

6961A

ICD-9 Finland

Psoriasis and similar disorders, Other psoriasis[PSORIASIS VULGARIS]

+∞

10.6

M07.3

ICD-10 Finland

Other psoriatic arthropathies

+∞

10.6

L04AB01

ATC

etanercept; parenteral

44.2

10.2

A07EC01

ATC

sulfasalazine; oral, rectal

7.5

10.1

H02AB06

ATC

prednisolone; systemic

3.6

9.7

397

M07.0*L40.5

ICD-10 Finland

Distal interphalangeal psoriatic arthropathy

+∞

9.5

6961B

ICD-9 Finland

Psoriasis and similar disorders, Other psoriasis[PSORIASIS PUSTULARIS]

+∞

9.5

69610

ICD-8 Finland

Psoriasis and similar disorders, Psoriasis pustulosa

+∞

9.5

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

8.1

9.4

L04AA01

ATC

[U] ciclosporin; systemic

26.6

9.1

L04AC05

ATC

ustekinumab; parenteral

54.3

8.8

D02AX

ATC

Other emollients and protectives

18.1

8.8

WXQ27

NOMESCO Finland

UVB narrow spectrum light therapy

30.1

8.7

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

7.1

8.0

L30.9

ICD-10 Finland

Dermatitis, unspecified

4.1

7.8

104

L27.0

ICD-10 Finland

Generalized skin eruption due to drugs and medicaments

27.2

7.7

D07AA02

ATC

hydrocortisone; topical

4.7

7.7

69619

ICD-8 Finland

Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)

+∞

7.4

6960A

ICD-9 Finland

Psoriasis and similar disorders, Psoriatic arthropathy

+∞

7.4

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

5.5

6.6

D05AA

ATC

Tars

73.8

6.5

S91

ICPC

Psoriasis

73.8

6.5

L40

ICD-10 Finland

Psoriasis

28.4

6.3

L04AC13

ATC

ixekizumab; parenteral

+∞

6.3

E000007

ATC

6.7

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42870588) Differential panel, method unspecified - Blood

341

4.12

14.20

14.3

6.9

—

(3037522) Nuclear Ab [Titer] in Serum

124

4.54

13.49

1.3

290.0

497.3

titre

—

(3013115) Eosinophils [#/volume] in Blood

534

3.39

9.43

17.9

6.9

0.2

e9/l

0.67

471

(40768443) Skin Pathology biopsy report

4.94

7.70

1.6

1.1

—

(3000475) Leukocytes [#/volume] in Synovial fluid

5.63

1.7

1.9

17332.3

21964.1

e6/l

—

(3021440) Promyelocytes/100 leukocytes in Blood

3.20

5.31

6.4

4.4

0.2

—

(3023420) DNA double strand Ab [Units/volume] in Serum

10.64

5.11

1.2

1.7

—

(3020682) Albumin/Creatinine [Ratio] in Urine

313

2.32

5.03

3.9

4.0

15.3

6.6

mg/mmol

0.63

198

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.30

4.97

1.2

1.5

—

(3021589) Normoblasts [#/volume] in Blood

481

2.26

4.89

20.1

11.2

0.0

e9/l

0.10

390

(40758558) Short blood count panel - Blood

270

2.31

4.79

13.2

8.6

—

(3021601) Nitrite [Presence] in Urine by Test strip

534

2.24

4.66

7.2

5.5

0.0

estimate

0.00

109

(3017181) Myelocytes/100 leukocytes in Blood

2.93

4.61

6.4

4.2

0.6

0.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

115

2.70

4.54

2.2

1.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

143

2.54

4.45

1.2

1.5

—

(3035350) Ketones [Presence] in Urine by Test strip

533

2.17

4.37

5.3

4.0

0.0

estimate

0.00

111

(3009508) Creatinine [Moles/volume] in Urine

314

2.17

4.26

3.1

7.6

mmol/l

0.02

263

(3044941) Cell count panel - Synovial fluid

7.35

4.24

1.4

1.5

—

(3009261) Glucose [Presence] in Urine by Test strip

543

2.10

4.05

5.3

4.0

0.0

estimate

0.00

104

(3017143) Hepatitis C virus Ab [Presence] in Serum

118

2.51

3.83

1.2

1.5

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

9.16

3.82

1.0

—

(3000494) Fungus identified in Specimen by Culture

125

2.47

3.82

1.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

522

2.04

3.81

9.4

7.7

1.2

mmol/l

0.34

438

(46235355) HIV 1 and 2 tests - Meaningful Use set

176

2.27

3.75

1.3

1.7

—

(3018095) Leukocytes [#/volume] in Urine

407

2.01

3.67

6.2

4.0

137.1

43.7

e6/l

0.32

293

(3037467) Urinalysis macro (dipstick) panel - Urine

726

2.09

3.40

7.1

4.6

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

253

2.05

3.40

2.8

2.0

3.3

3.1

mg/l

0.20

213

(3012516) Albumin [Mass/volume] in Urine

294

2.01

3.40

3.2

95.4

266.6

mg/l

0.35

184

(3021788) Differential panel - Synovial fluid

6.01

3.39

1.5

1.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.74

3.38

1.3

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

238

2.06

3.36

5.5

3.7

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

154

2.24

3.35

1.3

1.5

9.3

u/ml

—

(3023520) Reticulocytes [#/volume] in Blood

2.54

3.20

2.6

3.5

63.8

72.1

e9/l

0.57

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

468

1.90

3.18

8.9

6.5

1.2

mmol/l

1.50

422

(40760892) CBC W Ordered Manual Differential panel - Blood

227

2.03

3.15

8.6

5.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

102

2.39

3.08

4.3

3.8

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

104

849

2.16

3.04

13.4

7.8

77.5

79.6

u/l

0.24

790

(3015736) pH of Urine

412

1.85

2.94

5.2

3.9

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

170

2.00

2.57

1.4

1.3

31.7

29.0

iu/ml

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

5.66

2.57

1.2

1.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.38

2.36

1.6

1.4

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.64

2.31

1.8

1.4

—

(3018418) pH of Serum or Plasma

319

1.74

2.28

5.0

3.9

7.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

268

1.78

2.26

1.8

1.7

1.4

mmol/l

0.19

217

(3023368) Bacteria identified in Blood by Culture

304

1.74

2.21

5.2

4.8

—

(3026008) Bacteria identified in Urine by Culture

322

1.72

2.19

3.0

3.3

—

(3026493) Urate [Moles/volume] in Serum or Plasma

279

1.75

2.18

3.1

2.9

330.3

3826.1

umol/l

0.78

234

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.41

2.16

2.0

2.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.85

2.16

1.2

1.1

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.34

2.13

1.4

1.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

207

1.80

2.07

1.5

1.4

3.4

2.3

g/l

1.11

118

(3002582) Erythrocytes [#/volume] in Urine

357

1.65

1.97

4.9

3.5

15.7

50.1

e6/l

1.27

275

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.09

1.97

1.5

1.3

—

(3020779) Urea [Moles/volume] in Serum or Plasma

2.06

1.91

4.2

8.0

9.2

8.8

mmol/l

0.09

(3029937) Albumin [Presence] in Urine by Test strip

300

1.65

1.83

5.3

4.0

0.0

estimate

0.00

107

(3016879) Cocaine [Presence] in Urine

2.87

1.82

1.1

1.5

—

(3032080) INR in Blood by Coagulation assay

437

1.59

1.81

6.3

7.7

1.1

1.2

inr

0.50

133

(3052851) Hemolysis interference index of Serum or Plasma

2.77

1.75

2.4

3.1

—

(3000991) Gas panel - Venous blood

2.02

1.75

8.5

8.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

422

1.58

1.73

2.7

2.0

91.3

94.9

pmol/l

0.25

220

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

405

1.57

1.70

4.8

3.4

—

(3027944) Amphetamines [Presence] in Urine

2.68

1.69

1.1

1.4

—

(3028300) Cannabinoids [Presence] in Urine

2.68

1.69

1.1

1.5

—

(3027008) Opiates [Presence] in Urine

2.68

1.69

1.1

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

2.60

1.62

1.1

1.5

—

(3030467) Casts [#/volume] in Urine by Automated count

327

1.58

1.60

4.8

3.3

0.1

0.3

e6/l

2.37

246

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.79

1.60

2.3

1.7

—

(3000492) Spirometry study

102

1.89

1.54

1.4

1.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.68

1.54

1.4

1.1

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

585

1.52

1.53

6.4

7.1

12.4

11.9

umol/l

0.10

556

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

2.94

1.52

2.5

1.5

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

2.94

1.52

1.3

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

260

1.59

1.51

2.2

2.4

1.7

1.4

mg/l

0.16

211

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

226

1.62

1.49

1.5

1.2

14.4

0.8

u/ml

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.58

1.47

1.3

1.5

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.81

1.45

1.2

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

3.21

1.45

2.2

1.7

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

3.21

1.45

1.0

1.2

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.34

1.43

1.6

1.2

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

2.68

1.38

1.0

2.9

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

146

1.70

1.38

5.7

7.5

1.1

1.0

mmol/l

0.49

136

(3021960) Folate [Moles/volume] in Serum or Plasma

248

1.56

1.37

1.9

1.5

16.9

22.2

nmol/l

1.65

211

(36304419) Bacteria [Presence] in Urine

311

1.52

1.35

4.7

3.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

415

1.47

1.30

5.6

4.2

—

(3011288) Drugs identified in Urine by Screen method

2.85

1.29

1.8

2.1

—

(3012544) pH of Venous blood

109

1.76

1.27

2.9

5.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

306

1.50

1.26

4.1

3.8

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.47

1.26

1.7

1.1

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

2.69

1.22

3.8

2.2

4.4

4.2

e9/l

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

2.69

1.22

1.4

1.1

—

(40768804) Tissue Pathology biopsy report

438

1.45

1.22

2.3

1.9

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.37

1.20

1.3

1.4

—

(3022145) Colonoscopy Study observation

111

1.72

1.20

1.7

1.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

114

1050

1.74

1.19

29.0

15.7

19.2

23.5

mg/l

1.22

104

846

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.56

1.16

4.0

2.5

55.4

56.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

179

1.57

1.15

1.7

1.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.04

1.14

6.2

7.2

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.18

1.07

5.6

11.9

92.1

88.2

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.18

1.07

12.7

2.5

28.3

23.8

mmol/l

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.06

1.01

2.4

1.8

—

(3045414) Leukocytes [Presence] in Urine

1.90

1.01

2.3

1.7

—

(40761536) Microorganisms panel - Urine sediment

1.69

0.99

4.3

3.5

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.98

0.0

1.6

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

203

1.48

0.98

3.3

3.5

1076.0

116.7

ng/l

0.47

160

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.94

0.95

2.4

1.7

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.78

0.94

2.0

1.8

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.20

0.93

1.2

1.4

—

(3021901) Oxygen saturation in Capillary blood

2.20

0.93

7.5

2.3

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.20

0.93

2.2

3.7

211.8

195.5

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.87

0.87

4.6

2.8

—

(36660697) Celiac disease serology panel - Serum

1.67

0.85

1.4

1.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.71

0.85

3.4

3.3

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.69

0.81

18.3

6.0

3.3

0.9

mmol/l

0.65

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

124

1.52

0.80

2.6

1.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

124

1.52

0.80

2.8

1.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.86

0.80

1.3

2.0

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

110

1028

1.48

0.79

5.1

4.7

6.1

5.9

mmol/l

0.55

103

937

(3022313) Gas panel - Capillary blood

1.75

0.77

23.7

6.9

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.68

0.75

2.3

4.6

24.7

24.8

mmol/l

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.04

0.73

1.4

1.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.51

0.69

1.4

1.9

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

199

1.38

0.69

3.7

2.7

0.9

e6/l

0.01

117

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

105

982

1.37

0.67

7.3

5.8

41.4

40.0

mmol/mol

0.79

915

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

641

1.28

0.66

2.6

3.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.62

0.66

1.3

2.1

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

110

1037

1.41

0.66

5.9

4.5

4.6

mmol/l

0.40

105

960

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

183

1.38

0.66

4.5

3.0

1.5

1.6

e6/l

0.02

101

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

107

1005

1.38

0.65

5.2

4.0

1.3

mmol/l

0.62

102

917

(40768797) Stomach Pathology biopsy report

149

1.41

0.62

1.5

1.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.69

0.62

1.2

1.9

—

(3034770) Mitochondria Ab [Titer] in Serum

1.69

0.62

1.4

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

176

1.37

0.62

2.6

1.8

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

109

1029

1.38

0.62

5.3

4.4

1.4

1.5

mmol/l

0.50

104

943

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.61

0.0

1.0

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

0.00

0.61

0.0

1.5

—

2.9

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.61

0.0

1.8

—

136.0

—

(3042936) Bacteria identified in Isolate by Culture

159

1.38

0.60

2.0

2.2

—

(3044889) 12 lead EKG panel

748

1.26

0.59

4.3

4.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.55

0.58

1.2

1.7

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.49

0.58

2.8

2.9

60.8

63.5

ml/min/173m2

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

112

1066

1.38

0.56

6.0

5.0

2.7

mmol/l

0.08

106

973

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

100

0.58

0.54

1.3

1.9

—

(3019060) Gas panel - Arterial blood

1.51

0.52

2.6

3.7

—

(3020891) Body temperature

1.52

0.52

4.5

3.8

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

102

968

1.26

0.44

5.4

4.6

2.2

1.9

mu/l

0.72

866

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

0.62

0.44

5.0

2.7

5.3

6.5

ug/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.61

0.44

1.2

1.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.46

0.43

2.8

4.4

40.8

51.8

—

(3000330) Specific gravity of Urine by Test strip

1.43

0.43

3.6

5.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.43

0.43

1.9

1.7

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

1.58

0.42

1.4

0.3

0.2

g/l

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

1.54

0.42

3.6

6.7

3.7

g/l

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.54

0.42

1.4

1.2

1.1

g/l

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.7

—

16.8

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.41

0.0

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.41

0.0

1.4

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.41

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.4

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

795

1.20

0.41

4.8

3.9

14.8

pmol/l

0.01

706

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.3

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.3

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.40

0.0

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

245

1.24

0.40

6.0

2.7

—

(3043409) Potassium [Moles/volume] in Arterial blood

1.45

0.40

2.6

3.1

3.7

3.9

mmol/l

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.39

0.0

2.9

—

3.1

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.39

0.0

1.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.39

0.0

1.5

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.39

0.0

1.2

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.39

0.0

1.3

—

(3008898) HLA-B27 [Presence]

1.40

0.38

1.0

1.2

—

(3049717) Cytology report of Urine Cyto stain

1.41

0.35

1.3

2.6

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

629

1.17

0.35

5.7

4.9

7.0

6.6

mmol/l

0.68

589

(3003694) ABO and Rh group [Type] in Blood

281

0.82

0.33

1.3

1.4

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

223

1.21

0.31

1.8

1.9

403.5

461.2

pmol/l

0.43

185

(3025941) Bacteria identified in Stool by Culture

1.24

0.29

1.3

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.24

0.29

2.6

3.2

1.4

1.2

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.27

0.28

2.4

4.4

132.1

131.1

g/l

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

104

1.28

0.27

3.3

2.5

0.2

g/l

0.19

(3013512) EKG study

313

1.16

0.27

4.3

4.4

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.37

0.24

1.8

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

134

0.80

0.22

14.4

7.8

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

1.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.21

0.0

1.5

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

2.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.2

—

(21494755) Public health laboratory ask at order entry panel

1.23

0.20

1.2

1.4

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.1

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.1

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.1

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.1

—

(40761535) Cells panel - Urine sediment

1.24

0.20

3.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.18

0.19

1.0

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

963

1.12

0.17

33.4

15.8

39.5

40.0

0.25

704

(3002256) Pathology report gross observation

132

1.15

0.14

1.4

1.3

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

108

0.82

0.13

3.3

2.6

32.8

31.1

u/l

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

300

0.91

0.11

4.6

19.0

21.4

0.33

150

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

440

0.93

0.10

5.5

4.1

29.2

41.5

ng/l

0.56

316

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.81

0.08

1.4

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.03

0.07

1.4

1.5

—

(4010399)

1.02

0.07

1.3

1.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.84

0.07

1.9

1.7

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

101

996

1.06

0.06

26.9

14.2

82.6

80.0

ml/min/173m2

0.59

823

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

223

0.93

0.06

2.6

3.0

0.7

0.8

ug/l

0.50

144

(4035726)

100

1.11

0.05

1.8

1.3

—

(40761511) CBC panel - Blood by Automated count

110

1110

0.94

0.04

24.5

14.2

—

(3019225) pH of Specimen

1.08

0.02

7.5

5.0

—

(3044640) Blood type and Crossmatch panel - Blood

342

1.03

0.02

4.6

2.6

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

378

0.97

0.02

5.4

5.2

1.6

2.4

ug/l

1.73

331

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

137

1.02

0.00

1.6

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

499

1.00

0.00

7.6

4.3

—

(3003338) MCHC [Mass/volume]

897

1.01

0.00

40.3

19.5

329.4

332.2

g/l

2.29

892

(1761868) Lipid panel - Serum or Plasma

394

0.99

0.00

3.4

3.0

—

(3022621) pH of Urine by Test strip

1.02

0.00

4.0

2.4

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

0.93

0.00

1.3

3.4

4.6

pmol/l

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.6

—

(3003932) Carbon dioxide [Partial pressure] in Arterial cord blood

0.00

0.0

1.0

—

6.9

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

3.2

—

1.7

—

(37021550) Renin [Units/volume] in Plasma --upright

0.00

0.0

2.0

—

244.2

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.6

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

2.2

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3021706) Oxygen [Partial pressure] in Arterial cord blood

0.00

0.0

1.0

—

3.4

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.4

—

(42870560) Thyrotropin [Units/volume] in Cord blood

0.00

0.0

1.0

—

8.9

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.6

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.5

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

2.4

—

13.3

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

3.2

—

13.3

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.6

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.1

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.96

0.00

5.8

3.6

16.6

209.2

u/ml

—

(3004451) EKG impression Narrative

0.00

0.0

1.6

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.6

—

8.6

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3035880) pH of Pleural fluid

0.00

0.0

1.1

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

5.0

—

206.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.1

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.5

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

4.6

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.3

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3006598) pH of Arterial cord blood

0.00

0.0

1.0

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

3.0

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

3.0

—

(4024509)

0.00

0.0

1.3

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.5

—

160.6

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.6

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

32.8

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

1.8

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.2

—

(3000012) Reticulocyte production index

0.00

0.0

2.6

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

2.3

—

13.3

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

4.2

—

55.3

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PSORI_PUSTGEN and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_PSORI_PUSTGEN	2.109 [1.55, 2.87]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.011

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 289 females with L12_PSORI_PUSTGEN died.

Males

Parameter	HR [95% CI]	p-value
L12_PSORI_PUSTGEN	2.046 [1.29, 3.24]	0.002
Birth year	0.988 [0.98, 1.0]	0.01

During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 268 males with L12_PSORI_PUSTGEN died.

Mortality risk

Mortality risk for people of age

years, who have L12_PSORI_PUSTGEN.

N-year risk	Females	Males
1	0.185%	0.352%
5	0.897%	2.262%
10	2.342%	5.795%
15	4.631%	11.36%
20	8.298%	18.627%

Relationships between endpoints

↥

Index endpoint: L12_PSORI_PUSTGEN – Generalized pustular psoriasis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Generalized pustular psoriasis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints