No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
126 |
4. Check minimum number of eventsNone |
126 |
5. Include endpointsNone |
126 |
6. Filter based on genotype QC (FinnGen only) |
126 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
- Parent code in ICD-10
- H35
- Name in latin
- Striae angioides maculae
Similar endpoints
↥List of similar endpoints to
Degenerative macular diseases, drug-induced
based on the number of shared cases.
Similar with more cases:
- Degenerative macular diseases
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (not available in FinRegistry).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 126 | 56 | 70 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 63.45 | 63.47 | 63.43 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 104
- Matched controls
- 1041
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
+∞
128.8
104
18
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
46.9
30.8
37
12
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
40.1
14.0
17
5
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
21.4
12.6
18
10
CJB10
NOMESCO Finland
Laser discission of secondary cataract
6.4
11.0
31
65
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.5
9.6
39
122
S01BC03
ATC
diclofenac; ophthalmic
10.5
8.9
17
19
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.5
8.7
62
308
S01ED01
ATC
timolol; ophthalmic
7.5
8.5
20
32
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
8.4
8
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
6.8
7.7
19
33
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
32.5
7.3
9
*
H35.3
ICD-10 Finland
Degeneration of macula and posterior pole
32.5
7.3
9
*
H26.4
ICD-10 Finland
After-cataract
3.9
6.5
28
90
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.9
6.4
60
333
CKD99
NOMESCO Finland
Other intraoclular operations on vitreous body and retina
+∞
6.3
6
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.2
6.3
24
69
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
9.5
6.2
12
14
H26.2
ICD-10 Finland
Complicated cataract
13.7
6.2
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
13
30
4.72
5.44
2.0
2.5
0.2
0.4
u/ml
—
6
16
30
126
2.81
5.23
2.2
2.7
21.6
22.5
%
0.12
22
108
31
147
2.47
4.20
1.7
1.8
30.4
29.3
s
0.45
31
140
51
338
1.85
2.78
2.4
2.4
80.9
78.2
nmol/l
0.28
45
282
15
67
2.41
2.28
1.4
1.6
—
—
—
0
0
8
27
3.09
1.97
1.8
1.5
—
—
—
0
0
8
27
3.09
1.97
1.8
1.5
—
—
—
0
0
48
340
1.67
1.96
3.6
3.3
—
—
—
0
0
20
110
1.97
1.86
2.0
4.3
216.1
253.9
u/l
1.43
20
105
59
457
1.55
1.60
6.5
6.8
1.2
1.2
mmol/l
0.28
50
378
6
20
3.10
1.60
1.2
1.2
—
—
—
0
0
30
199
1.67
1.54
2.0
1.6
1.4
1.3
mmol/l
0.19
21
161
7
27
2.68
1.54
1.7
1.2
—
—
—
0
0
34
235
1.61
1.49
2.5
2.0
3.1
3.2
mg/l
0.14
29
205
5
16
3.21
1.45
1.0
1.4
—
—
—
0
0
14
76
1.95
1.36
6.5
7.2
12.7
10.7
mmol/l
0.37
14
69
55
432
1.48
1.34
4.2
4.4
0.0
0.0
estimate
—
10
75
38
276
1.54
1.34
3.8
3.3
1.0
0.3
e6/l
0.63
28
210
9
43
2.18
1.33
1.3
1.7
—
—
—
0
0
20
126
1.70
1.24
4.7
6.1
1.1
1.0
mmol/l
0.32
20
113
19
119
1.70
1.20
1.8
1.7
—
—
—
0
0
50
398
1.42
1.10
2.4
2.4
—
—
—
0
0
53
430
1.40
1.04
4.1
4.4
0.0
0.0
estimate
—
9
78
93
836
1.43
0.96
24.3
17.5
32.5
25.1
mg/l
1.07
77
694
6
27
2.28
0.95
1.2
1.2
—
—
—
0
0
27
196
1.48
0.95
1.5
1.7
0.8
1.5
mg/l
1.78
21
150
52
426
1.38
0.94
5.5
6.1
0.0
0.0
estimate
—
10
77
29
214
1.46
0.94
1.9
1.9
395.9
442.0
pmol/l
0.48
20
178
6
28
2.20
0.93
1.2
1.2
—
—
—
0
0
23
163
1.50
0.90
3.8
2.9
0.4
1.1
e6/l
2.17
12
101
96
872
1.42
0.90
26.8
20.3
87.1
83.5
umol/l
0.63
96
872
42
336
1.38
0.87
3.0
3.4
1673.8
1804.9
ng/l
0.10
35
278
18
122
1.55
0.86
1.9
1.8
—
—
—
0
0
6
34
1.80
0.77
1.2
1.2
—
—
—
0
0
5
24
2.13
0.75
1.8
1.5
—
—
—
0
0
21
154
1.44
0.71
4.0
3.2
0.2
2.7
e6/l
—
10
92
46
386
1.30
0.68
2.5
2.1
104.5
88.6
pmol/l
1.07
23
196
5
28
1.82
0.67
1.0
1.4
—
—
—
0
0
34
276
1.32
0.63
6.2
4.7
21.0
21.7
%
0.13
21
133
86
788
1.29
0.62
4.7
4.6
4.3
4.5
mmol/l
0.61
75
705
89
820
1.29
0.60
5.6
5.1
2.5
2.6
mmol/l
0.35
78
729
8
53
1.54
0.59
3.7
3.6
0.8
0.1
e6/l
—
8
53
85
781
1.27
0.58
4.6
4.5
1.4
1.4
mmol/l
0.12
74
692
58
511
1.25
0.56
8.0
8.8
4.4
4.3
e9/l
0.14
48
445
84
775
1.25
0.53
7.1
6.2
41.0
41.3
mmol/mol
0.12
78
707
18
136
1.38
0.53
1.3
1.2
96.6
35.5
iu/ml
—
6
40
94
881
1.26
0.50
12.5
10.9
25.5
24.4
u/l
0.36
94
837
8
56
1.46
0.43
1.4
1.5
—
—
—
0
0
13
96
1.39
0.43
5.6
3.5
—
—
—
0
0
41
357
1.22
0.43
5.7
5.2
2.5
2.2
ug/l
0.30
36
307
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
21
171
1.27
0.39
1.9
1.9
—
—
—
0
0
13
99
1.35
0.37
3.3
4.9
5.7
5.8
kpa
0.07
13
94
80
752
1.17
0.34
4.1
4.1
1.2
1.3
mmol/l
0.20
69
665
32
284
1.17
0.27
2.7
2.4
56.0
55.2
u/l
0.05
27
259
79
755
1.12
0.22
5.7
4.5
1.9
2.0
mu/l
0.32
74
652
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
45
418
1.12
0.20
3.8
4.5
31.9
49.5
ng/l
0.68
36
314
42
390
1.12
0.18
3.9
4.0
—
—
—
0
0
15
129
1.18
0.18
7.5
5.9
5.0
5.1
kpa
0.29
15
122
15
129
1.18
0.18
7.5
5.9
13.5
11.2
kpa
0.62
15
122
10
82
1.24
0.17
1.3
1.2
—
—
—
0
0
8
69
1.17
0.17
1.6
1.3
—
—
—
0
0
24
221
1.11
0.12
2.0
1.8
1069.6
1154.2
nmol/l
0.17
18
162
22
202
1.11
0.11
2.3
2.4
—
—
—
0
0
79
770
1.07
0.10
25.2
16.2
71.9
73.0
ml/min/173m2
0.15
62
629
5
61
0.81
0.08
2.0
1.9
—
—
—
0
0
81
802
1.03
0.02
5.0
4.8
6.1
6.1
mmol/l
0.10
70
709
24
233
1.04
0.01
4.2
4.5
0.0
0.0
estimate
—
8
70
34
341
1.00
0.00
4.4
4.8
—
—
—
0
0
11
108
1.02
0.00
6.9
9.1
—
—
—
0
0
7
71
0.99
0.00
6.0
5.7
23.7
24.5
mmol/l
—
7
65
0
5
0.00
0.00
0.0
4.8
—
57.8
—
0
5
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
67.6
—
0
5
Mortality – FinRegistry
↥This endpoint is excluded (not available in FinRegistry).
Relationships between endpoints
↥Index endpoint: MACULA_NAS_ADVERSE – Degenerative macular diseases, drug-induced
GWS hits: -
This endpoint is excluded (not available in FinRegistry).