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Degenerative macular diseases, drug-induced

Endpoint Browser PheWeb

MACULA_NAS_ADVERSE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs — ANY
  • Hospital discharge: ICD-10 — H35.39#

1 out of 7 registries used, show all original rules.

127

4. Check minimum number of events

None

127

5. Include endpoints

None

127

6. Filter based on genotype QC (FinnGen only)

125

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
H35
Name in latin
Striae angioides maculae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 125 54 71
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 63.88 63.47 64.20

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
127
Matched controls
1270
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
+∞
155.7
127
24
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
36.1
65.7
45
19
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
34.6
18.2
23
8
CJB10
NOMESCO Finland
Laser discission of secondary cataract
5.9
17.3
39
89
S01BC03
ATC
diclofenac; ophthalmic
27.7
17.2
23
10
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
23.1
16.3
23
12
H26.4
ICD-10 Finland
After-cataract
5.3
15.9
41
105
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
5.8
10.5
21
42
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.6
10.3
46
172
H26.2
ICD-10 Finland
Complicated cataract
43.8
10.2
12
*
H35.3
ICD-10 Finland
Degeneration of macula and posterior pole
59.7
9.8
11
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.2
9.5
76
402
S01ED01
ATC
timolol; ophthalmic
7.9
9.3
21
31
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.2
9.0
28
81
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
4.4
8.9
25
67
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
17.9
8.8
13
8
ZXD10
NOMESCO Finland
Scheduled procedure
3.0
8.6
66
335
CKD99
NOMESCO Finland
Other intraoclular operations on vitreous body and retina
+∞
8.4
8
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.1
8.3
26
75
H35.7
ICD-10 Finland
Separation of retinal layers
19.9
7.7
11
6
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
73.4
6.5
7
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.6
6.3
75
456
S01FA01
ATC
atropine; ophthalmic
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
30
129
2.74
4.98
2.2
2.7
21.64
22.59
%
0.13
22
111
50
280
2.30
4.71
3.6
4.1
7.40
7.40
ph
—
9
54
31
149
2.43
4.07
1.7
1.8
30.42
29.31
s
0.44
31
142
80
600
1.90
3.00
4.8
4.2
—
—
—
0
0
17
77
2.39
2.51
6.7
8.9
—
—
—
0
0
10
32
3.30
2.50
2.9
4.1
—
—
—
0
0
48
337
1.68
2.04
4.2
3.9
27.97
89.01
e6/l
1.74
34
254
38
255
1.70
1.89
3.8
3.2
—
—
—
0
0
63
488
1.58
1.74
27.1
15.7
1.30
1.30
inr
0.01
20
141
31
201
1.72
1.73
2.0
1.6
1.32
1.29
mmol/l
0.08
22
162
6
19
3.26
1.68
1.3
3.0
—
—
—
0
0
43
308
1.60
1.64
3.9
3.4
30.30
254.55
e6/l
0.56
32
240
59
462
1.52
1.49
6.5
6.9
1.22
1.21
mmol/l
0.27
51
385
6
22
2.81
1.45
1.2
2.1
—
—
—
0
0
34
239
1.58
1.38
2.5
2.0
3.10
3.24
mg/l
0.13
29
208
6
24
2.57
1.32
2.7
2.8
—
—
—
0
0
18
280
0.58
1.29
4.4
4.8
—
—
—
0
0
38
279
1.52
1.27
3.8
3.3
0.99
0.34
e6/l
0.70
29
214
14
78
1.89
1.27
6.5
7.1
12.66
10.65
mmol/l
0.37
14
71
55
437
1.46
1.24
4.2
4.4
0.00
0.00
estimate
—
10
77
13
72
1.90
1.20
1.5
1.6
—
—
—
0
0
19
119
1.70
1.20
1.4
1.3
—
—
—
0
0
6
26
2.37
1.20
1.5
1.3
—
—
—
0
0
43
329
1.46
1.17
2.5
2.1
—
—
—
0
0
10
51
2.04
1.14
7.6
7.4
—
—
—
0
0
20
129
1.65
1.14
4.7
6.1
1.06
1.02
mmol/l
0.36
20
116
12
66
1.90
1.13
3.1
4.2
—
—
—
0
0
28
199
1.52
1.08
1.5
1.7
0.76
1.53
mg/l
1.77
21
152
9
45
2.07
1.07
1.1
1.3
—
—
—
0
0
5
22
2.32
1.04
1.6
1.2
0.99
1.13
g/l
—
5
22
28
201
1.50
1.03
3.3
4.1
—
—
—
0
0
30
219
1.48
1.02
1.9
1.9
388.57
440.48
pmol/l
0.59
21
182
34
255
1.46
1.01
4.3
3.1
6.74
7.52
mmol/l
0.51
29
211
47
375
1.40
1.00
12.7
9.9
0.00
0.00
e9/l
0.09
37
303
94
845
1.43
0.97
24.0
17.6
32.48
25.14
mg/l
1.07
77
703
40
312
1.41
0.97
5.8
4.4
—
—
—
0
0
33
249
1.44
0.95
4.3
3.1
1646.15
532.48
mg/l
0.30
23
170
53
436
1.37
0.93
4.3
4.4
0.00
0.00
estimate
—
10
86
6
28
2.20
0.93
1.2
1.2
—
—
—
0
0
43
343
1.38
0.91
3.6
4.2
—
5.86
—
0
25
97
881
1.43
0.91
26.6
20.4
87.01
83.50
umol/l
0.60
97
881
6
29
2.12
0.90
2.8
2.6
1.95
1.71
mg/l
—
6
24
96
872
1.41
0.89
19.9
16.4
—
—
—
0
0
52
431
1.35
0.86
5.5
6.1
0.00
0.00
estimate
—
10
79
11
65
1.76
0.85
1.1
1.6
—
—
—
0
0
6
32
1.92
0.83
1.0
1.2
—
—
—
0
0
6
32
1.92
0.83
2.2
3.8
—
—
—
0
0
47
390
1.33
0.76
2.5
2.1
104.47
89.18
pmol/l
1.01
23
199
21
155
1.43
0.68
4.0
3.2
0.24
2.74
e6/l
—
10
92
87
797
1.29
0.63
4.7
4.6
4.32
4.49
mmol/l
0.71
76
712
90
829
1.29
0.61
5.6
5.1
2.51
2.62
mmol/l
0.43
79
735
8
53
1.54
0.59
3.8
3.6
0.77
0.13
e6/l
—
8
53
14
98
1.48
0.59
3.2
4.9
0.36
1.97
mmol/l
0.76
14
77
86
790
1.27
0.59
4.6
4.5
1.43
1.44
mmol/l
0.09
75
698
85
783
1.26
0.55
7.1
6.2
41.03
41.28
mmol/mol
0.10
79
714
9
62
1.49
0.54
4.1
3.5
—
—
—
0
0
18
136
1.38
0.53
2.9
1.9
—
—
—
0
0
6
40
1.52
0.52
1.2
1.4
—
—
—
0
0
6
40
1.52
0.52
1.5
1.3
—
—
—
0
0
98
921
1.28
0.51
32.9
24.5
30.42
30.39
pg
0.05
98
896
98
921
1.28
0.51
33.1
24.6
6.75
6.84
e9/l
0.20
98
877
98
921
1.28
0.51
33.5
24.7
38.31
39.19
%
0.55
90
854
98
921
1.28
0.51
32.9
24.6
91.47
91.59
fl
0.09
98
896
98
921
1.28
0.51
33.1
24.6
4.32
4.41
e12/l
0.94
98
877
98
921
1.28
0.51
33.0
24.6
243.52
239.21
e9/l
0.25
98
883
18
137
1.37
0.51
1.3
1.2
96.63
38.42
iu/ml
—
6
42
58
517
1.22
0.49
8.0
8.8
4.40
4.32
e9/l
0.10
48
451
12
86
1.44
0.46
1.3
1.3
—
—
—
0
0
12
86
1.44
0.46
1.7
1.3
—
—
—
0
0
45
393
1.22
0.46
7.0
5.4
0.61
0.63
%
0.08
45
361
42
365
1.23
0.45
5.6
5.2
2.51
2.15
ug/l
0.42
37
315
14
105
1.37
0.43
1.8
1.3
—
—
—
0
0
46
406
1.21
0.42
6.9
5.8
9.27
8.91
%
0.33
46
377
32
272
1.24
0.42
4.8
3.8
6.10
7.99
mg/mmol
0.26
22
180
15
191
0.76
0.40
1.6
1.3
—
—
—
0
0
46
409
1.20
0.39
6.6
5.7
—
—
—
0
0
50
448
1.19
0.39
6.1
5.4
0.17
0.19
e9/l
0.42
42
389
13
99
1.35
0.37
3.3
4.9
5.73
5.80
kpa
0.07
13
94
26
219
1.24
0.37
6.8
6.9
—
—
—
0
0
67
619
1.17
0.36
4.6
4.7
—
—
—
0
0
10
73
1.40
0.35
1.0
1.6
—
—
—
0
0
81
761
1.18
0.34
4.1
4.1
1.22
1.26
mmol/l
0.22
70
671
46
415
1.17
0.32
6.9
5.7
25.24
25.49
%
0.05
46
384
14
111
1.29
0.31
7.8
6.8
96.64
94.71
%
1.09
14
106
38
338
1.18
0.31
2.8
3.5
—
—
—
0
0
10
75
1.36
0.31
1.4
1.4
—
—
—
0
0
13
103
1.29
0.29
1.6
1.5
—
—
—
0
0
81
767
1.15
0.29
5.7
4.5
1.88
2.03
mu/l
0.50
76
663
47
433
1.14
0.24
6.2
5.0
0.66
0.62
e9/l
0.37
40
373
48
443
1.13
0.24
6.6
5.1
1.63
1.83
e9/l
0.65
41
393
47
434
1.13
0.23
6.2
5.1
0.04
0.04
e9/l
0.25
40
374
10
79
1.29
0.23
2.9
3.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
33.54
—
0
11
0
10
0.00
0.21
0.0
1.3
—
129.20
—
0
5
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
3.5
—
4.18
—
0
13
5
65
0.76
0.17
1.6
1.3
—
—
—
0
0
12
101
1.21
0.17
2.5
1.6
—
—
—
0
0
45
422
1.10
0.16
3.8
4.4
31.92
49.31
ng/l
0.67
36
317
15
130
1.17
0.16
7.5
6.1
5.00
5.15
kpa
0.31
15
123
15
130
1.17
0.16
7.5
6.1
13.53
11.23
kpa
0.61
15
123
7
85
0.81
0.15
3.0
3.7
—
—
—
0
0
26
280
0.91
0.12
3.3
2.5
—
—
—
0
0
6
53
1.14
0.09
1.3
1.1
—
—
—
0
0
24
224
1.09
0.09
2.0
1.8
1069.56
1164.77
nmol/l
0.20
18
163
5
61
0.81
0.08
2.4
5.6
—
—
—
0
0
9
85
1.06
0.07
2.9
3.4
4.62
4.17
kpa
—
9
79
16
148
1.09
0.06
1.3
1.3
2.32
2.80
g/l
—
7
88
11
102
1.09
0.03
1.1
1.8
—
—
—
0
0
24
249
0.96
0.03
3.7
3.4
—
—
—
0
0
82
811
1.03
0.02
5.0
4.9
6.05
6.10
mmol/l
0.15
71
717
24
237
1.02
0.00
4.2
4.5
0.00
0.00
estimate
—
8
72
25
247
1.02
0.00
4.1
4.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
260.50
—
0
8
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
7.06
—
0
7
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
64.68
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
0.86
—
0
6
0
9
0.00
-0.00
0.0
2.8
—
—
—
0
0
7
71
0.99
-0.00
6.0
5.7
23.74
24.58
mmol/l
—
7
66
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
233.00
—
0
5
0
5
0.00
-0.00
0.0
4.6
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: MACULA_NAS_ADVERSE – Degenerative macular diseases, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).