macular degeneration: Loss of vision in the central portion of the retina (macula), secondary to retinal degeneration. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
4816 |
4. Check minimum number of eventsNone |
4816 |
5. Include endpointsNone |
4816 |
6. Filter based on genotype QC (FinnGen only) |
4816 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 5
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H35
- Name in latin
- Striae angioides maculae
Similar endpoints
↥List of similar endpoints to
Degenerative macular diseases
based on the number of shared cases.
Similar with more cases:
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 33887 | 19783 | 14000 |
| Only index persons | 32124 | 18934 | 13190 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.49 | 0.57 | 0.39 |
| Only index persons | 0.62 | 0.70 | 0.50 |
| Median age at first event (years) | |||
| Whole population | 70.47 | 70.87 | 69.89 |
| Only index persons | 70.16 | 70.58 | 69.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4816 | 2602 | 2214 |
| Unadjusted period prevalence (%) | 0.93 | 0.89 | 0.98 |
| Median age at first event (years) | 68.64 | 67.39 | 70.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 4298
- Matched controls
- 42981
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
104.7
323.0
373
39
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
384.2
323.0
483
14
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
401.6
323.0
755
23
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.7
323.0
2729
11546
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
11.2
323.0
718
757
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.9
323.0
1683
3652
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
322.7
323.0
875
34
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
683.2
323.0
592
10
WX140
NOMESCO Finland
Parabulbar anesthesy
26.7
323.0
914
431
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
136.8
323.0
784
70
H35.37
ICD-10 Finland
Macular holes
845.8
323.0
386
5
XCW99
NOMESCO Finland
Other investigative procedure of eye
11.4
323.0
1495
1926
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
3096.9
323.0
800
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.5
323.0
2747
12090
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
70.2
323.0
731
125
XCK10
NOMESCO Finland
Photography of fundus of eye
7.2
323.0
1113
2001
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
4503599627370496.0
323.0
4297
12
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
12.6
323.0
1101
1144
H33.0
ICD-10 Finland
Retinal detachment with retinal break
980.2
323.0
360
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
314.1
323.0
836
33
XCD20
NOMESCO Finland
Photoangiography of eye
118.3
313.4
338
31
H26.4
ICD-10 Finland
After-cataract
5.2
309.2
1103
2658
CJB10
NOMESCO Finland
Laser discission of secondary cataract
5.4
294.1
1002
2277
H25.1
ICD-10 Finland
Senile nuclear cataract
3.4
293.1
2164
9936
CKC12
NOMESCO Finland
Photocoagulation of retina
83.1
267.8
301
39
CKD40
NOMESCO Finland
Endophotocoagulation of retina
253.5
257.4
262
11
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.1
249.3
1168
3603
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
189.4
224.5
233
13
S01BC05
ATC
ketorolac; ophthalmic
6.8
221.5
603
1005
H33.3
ICD-10 Finland
Retinal breaks without detachment
319.3
209.4
211
7
H35.7
ICD-10 Finland
Separation of retinal layers
1047.1
205.9
200
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
129.1
195.1
209
17
S01ED51
ATC
timolol, combinations; ophthalmic
4.4
186.7
754
1965
S01BC03
ATC
diclofenac; ophthalmic
11.9
183.9
352
321
H35.36
ICD-10 Finland
Macular cyst
1865.2
177.2
171
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
218.4
163.3
168
8
H3601, E113
ICD-10 Finland
NA
+∞
160.4
153
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
134.0
2187
13630
XCK00
NOMESCO Finland
Perimetry
4.2
133.3
562
1494
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
100.7
132.9
146
15
H35.9
ICD-10 Finland
Retinal disorder, unspecified
200.5
131.4
136
7
H26.2
ICD-10 Finland
Complicated cataract
18.1
120.4
191
110
H43.1
ICD-10 Finland
Vitreous haemorrhage
13.7
116.2
206
157
XCH00
NOMESCO Finland
Eye pressure measurement
5.5
106.9
336
651
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
1032.7
103.7
101
*
H36.01
ICD-10 Finland
Diabetic maculopathy
345.1
101.5
102
*
H3600, E113
ICD-10 Finland
NA
+∞
101.4
97
*
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
177.5
99.7
104
6
H35.8
ICD-10 Finland
Other specified retinal disorders
334.6
98.4
99
*
H3603, E113
ICD-10 Finland
NA
+∞
96.2
92
*
S01EC01
ATC
acetazolamide; systemic
7.4
96.2
240
342
CK2Y4
NOMESCO Finland
OCT video recording of ocular fundus
202.6
95.8
99
5
ZXA05
NOMESCO Finland
Left side
2.1
92.6
1395
7998
H25.8
ICD-10 Finland
Other senile cataract
2.5
86.6
796
3594
CKD20
NOMESCO Finland
Removal of vitreous body substitute
425.8
84.3
84
*
S01ED01
ATC
timolol; ophthalmic
4.2
84.3
343
868
H20.1
ICD-10 Finland
Chronic iridocyclitis
13.8
84.0
148
111
CKC15
NOMESCO Finland
Panretinal photocoagulation
177.5
83.4
87
5
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
5.0
82.6
279
584
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
214.1
81.6
84
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
404.9
80.2
80
*
114
Kela drug reimbursment
Glaucoma
2.6
79.4
645
2706
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.4
79.0
757
3476
ZXA10
NOMESCO Finland
Bilateral
2.1
76.6
1007
5366
ZXA00
NOMESCO Finland
Right side
1.9
76.4
1405
8570
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
+∞
76.3
73
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
24.9
75.3
107
44
H25.0
ICD-10 Finland
Senile incipient cataract
3.2
73.5
432
1469
S01EE01
ATC
latanoprost; ophthalmic
2.9
70.1
470
1746
H3603, E103
ICD-10 Finland
NA
+∞
68.9
66
*
H35.6
ICD-10 Finland
Retinal haemorrhage
180.4
68.2
71
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
16.1
66.9
110
70
XCD10
NOMESCO Finland
Electrophysiological examination of eye
5.5
66.3
204
383
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
4.5
66.2
246
568
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
8.4
65.9
149
182
ZX198
NOMESCO Finland
Other local administration
20.2
65.4
99
50
WX002
NOMESCO Finland
Sedation and analgesia
2.0
64.8
991
5566
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
64.7
62
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
637.4
64.0
63
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
216.4
62.3
64
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
39.7
61.8
78
20
A10AA02
ATC
NA
5.8
61.6
182
325
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.7
60.7
451
1780
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
301.2
58.4
59
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
12.9
58.4
105
83
H35.4
ICD-10 Finland
Peripheral retinal degeneration
149.5
56.0
59
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
9.9
55.5
114
118
CKC60
NOMESCO Finland
Local buckling of sclera using implant
544.8
54.7
54
*
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
5.5
53.6
166
314
H40.0
ICD-10 Finland
Glaucoma suspect
2.6
52.9
424
1741
CKC30
NOMESCO Finland
Cryopexy of detached retina
524.2
52.6
52
*
H3601, E103
ICD-10 Finland
NA
+∞
52.2
50
*
A10AA01
ATC
NA
8.3
51.3
117
145
S01EC04
ATC
brinzolamide; ophthalmic
3.2
51.1
285
928
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
73.6
51.1
58
8
H3600, E103
ICD-10 Finland
NA
+∞
50.1
48
*
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
5.2
49.5
159
314
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
69.5
48.1
55
8
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.9
48.0
310
1114
H26.02
ICD-10 Finland
Presenil cataract
4.6
47.6
172
386
1LA05
NOMESCO Finland
NA
+∞
45.9
44
*
A98
ICPC
Health maint/preventive medicine
1.9
41.2
3820
34772
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.5
41.1
346
1455
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.5
40.5
329
1356
S01EA03
ATC
apraclonidine; ophthalmic
8.5
40.2
89
106
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
201.8
38.9
40
*
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
38.1
38.7
49
13
CKD99
NOMESCO Finland
Other intraoclular operations on vitreous body and retina
196.7
37.8
39
*
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
37.3
37.8
48
13
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
4.6
36.9
133
298
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.6
36.8
280
1110
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
131.1
36.7
39
*
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
36.5
35
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.5
35.0
171
504
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.8
34.6
118
250
H30.2
ICD-10 Finland
Posterior cyclitis
+∞
34.4
33
*
T89
ICPC
Diabetes insulin dependent
4.2
34.3
133
321
N02BE01
ATC
paracetamol; systemic, rectal
1.6
33.2
3557
32086
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
25.8
33.2
46
18
H53.1
ICD-10 Finland
Subjective visual disturbances
2.5
33.0
273
1132
H52.1
ICD-10 Finland
Myopia
4.9
32.3
109
229
H33.4
ICD-10 Finland
Traction detachment of retina
319.3
31.9
32
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
31.4
1915
15196
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
33.6
30.9
40
12
WX142
NOMESCO Finland
Sub-tenon anesthesy
13.7
30.7
53
39
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
110.8
30.7
33
*
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
16.2
29.8
48
30
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
29.7
400
2082
A10AE05
ATC
insulin detemir; parenteral
2.6
29.4
232
939
S01EE03
ATC
bimatoprost; ophthalmic
3.2
29.2
161
521
A10AE04
ATC
insulin glargine; parenteral
2.0
28.9
386
2000
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
7.8
28.4
66
86
S01EC03
ATC
dorzolamide; ophthalmic
3.9
27.6
118
312
WX110
NOMESCO Finland
Local anesthesy
1.4
26.7
2405
20309
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
11.8
26.6
49
42
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.3
26.3
134
409
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
7.2
26.2
64
90
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
21.3
26.0
38
18
S01FA04
ATC
cyclopentolate; ophthalmic
6.3
26.0
70
113
CS494
NOMESCO Finland
Other visual field testing
3.5
25.8
122
352
H33.2
ICD-10 Finland
Serous retinal detachment
73.1
25.8
29
*
S01EE05
ATC
tafluprost; ophthalmic
2.6
25.3
191
755
TCK00
NOMESCO Finland
Photosensitisation of choroid and retina
+∞
25.0
24
*
H35.3
ICD-10 Finland
Degeneration of macula and posterior pole
+∞
25.0
24
*
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
2.7
24.8
179
688
H34.2
ICD-10 Finland
Other retinal artery occlusions
90.6
24.7
27
*
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
2.8
24.4
165
609
H44.2
ICD-10 Finland
Degenerative myopia
27.7
24.4
33
12
H34.1
ICD-10 Finland
Central retinal artery occlusion
87.2
23.7
26
*
H33.5
ICD-10 Finland
Other retinal detachments
12.5
23.0
41
33
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
10.6
22.8
44
42
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
10.3
22.0
43
42
J01DB01
ATC
cefalexin; oral
1.4
21.7
3117
28030
H40.11
ICD-10 Finland
Low pressure glaucoma
3.0
21.6
130
447
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
21.3
2655
23258
S01EE04
ATC
travoprost; ophthalmic
2.9
21.2
134
477
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.7
21.0
441
2670
H3602, E113
ICD-10 Finland
NA
+∞
20.8
20
*
H02AB06
ATC
prednisolone; systemic
1.4
20.7
1839
15210
S01EX03
ATC
NA
2.7
20.7
143
538
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.5
20.6
958
7049
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
3.0
20.5
120
407
S01EC54
ATC
brinzolamide, combinations; ophthalmic
4.0
20.4
82
207
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
3.8
20.4
87
232
CA1ME
NOMESCO Finland
Ultrasound oculometry
5.7
20.3
58
102
H53.4
ICD-10 Finland
Visual field defects
3.2
20.2
108
344
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
12.1
20.0
36
30
S18
ICPC
Laceration/cut
1.4
19.8
1678
13745
C08CA01
ATC
amlodipine; oral
1.4
19.6
1608
13088
SPAT1325
SPAT
Vaccination
1.4
19.2
1521
12299
SPAT1262
SPAT
Handing over of treatment supplies
1.5
19.1
748
5302
AA1AD
NOMESCO Finland
CT of head and brain
1.4
18.9
1043
7913
A02BC05
ATC
esomeprazole; systemic
1.4
18.8
1531
12429
A02BC02
ATC
pantoprazole; systemic
1.3
18.7
2583
22741
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
8.3
18.6
41
50
R42
ICD-10 Finland
Dizziness and giddiness
1.4
18.6
940
7016
CKD50
NOMESCO Finland
Endodiathermy of retina
190.8
18.5
19
*
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
18.4
2012
17076
H04AA01
ATC
glucagon; nasal, parenteral
5.3
18.4
56
107
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
12.4
18.1
32
26
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
18.0
2281
19768
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
2.4
17.5
156
675
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
17.4
1162
9097
SPAT1312
SPAT
General health counselling
1.4
17.4
1165
9123
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
10.7
17.4
33
31
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
17.3
1673
13895
XCH05
NOMESCO Finland
Eye pressure longterm registration
4.6
17.2
59
129
XCW10
NOMESCO Finland
Assessment of vision
7.5
17.1
40
54
M79.6
ICD-10 Finland
Pain in limb
1.4
17.1
1305
10436
SPAT1263
SPAT
Sampling
1.3
17.0
1632
13526
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
16.8
454
2940
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
2.9
16.7
102
356
H35.29
ICD-10 Finland
Other proliferative retinopathy
+∞
16.7
16
*
H27.1
ICD-10 Finland
Dislocation of lens
6.9
16.6
41
60
S01FA01
ATC
atropine; ophthalmic
6.4
16.5
43
68
H30.9
ICD-10 Finland
Chorioretinal inflammation, unspecified
170.6
16.5
17
*
H44.0
ICD-10 Finland
Purulent endophthalmitis
40.2
16.3
20
5
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
2.9
16.3
100
352
H40.9
ICD-10 Finland
Glaucoma, unspecified
2.8
16.1
104
377
H53.9
ICD-10 Finland
Visual disturbance, unspecified
2.7
16.1
112
424
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.4
16.0
889
6722
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
15.9
1455
11939
R51.80
ICD-10 Finland
Headache
1.6
15.8
431
2800
E10
ICD-10 Finland
Type 1 diabetes mellitus
5.2
15.7
48
93
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
2.9
15.7
96
337
H16.0
ICD-10 Finland
Corneal ulcer
2.2
15.6
152
689
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
19.3
15.5
23
12
C10AA05
ATC
atorvastatin; oral
1.3
15.5
1633
13664
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
15.5
878
6660
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
13.1
15.1
26
20
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
15.1
1081
8523
CKA10
NOMESCO Finland
Biopsy of vitreous body
45.1
15.0
18
*
SPAT1153
SPAT
Removal of sutures
1.3
14.9
1289
10463
Z01.2
ICD-10 Finland
Dental examination
1.3
14.9
1230
9914
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.8
14.9
272
1573
UJF32
NOMESCO Finland
Coloscopy
1.4
14.8
1022
8007
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
10.4
14.7
28
27
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
14.6
14
*
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
14.6
1744
14816
103
Kela drug reimbursment
Diabetes, insulin-treated
1.3
14.3
1078
8554
C03CA01
ATC
furosemide; systemic
1.3
14.3
1424
11781
A10AA03
ATC
NA
5.6
14.3
41
74
H43.3
ICD-10 Finland
Other vitreous opacities
3.7
14.3
61
165
SPAT1310
SPAT
Counselling related to known health issue
1.3
14.1
1181
9527
L04AA06
ATC
mycophenolic acid; systemic
3.7
14.0
60
163
N03AX12
ATC
gabapentin; oral
1.5
14.0
539
3785
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.1
14.0
160
779
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
14.0
1159
9331
177
Kela drug reimbursment
Insulin glargine 300 U / ml
3.2
13.9
71
222
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
13.9
812
6181
A10AE06
ATC
insulin degludec; parenteral
3.0
13.7
79
268
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.4
13.6
781
5918
L03
ICPC
Low back symptom/complaint
1.4
13.6
817
6241
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
6.9
13.6
33
48
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
4.7
13.6
45
96
H36.02
ICD-10 Finland
Preproliferative diabetic retinopathy
+∞
13.5
13
*
1LA01
NOMESCO Finland
NA
+∞
13.5
13
*
H57.1
ICD-10 Finland
Ocular pain
2.5
13.5
105
427
L17
ICPC
Foot/toe symptom/complaint
1.4
13.5
936
7323
NHQ40
NOMESCO Finland
Amputation of toe
3.0
13.3
77
262
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
13.3
1657
14101
H54.7
ICD-10 Finland
Unspecified visual loss
5.5
13.2
38
69
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
2.7
13.0
87
326
H35
ICD-10 Finland
Other retinal disorders
28.4
12.9
17
6
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
9.3
12.9
26
28
Z94.0
ICD-10 Finland
Kidney transplant status
4.9
12.9
41
84
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.4
12.8
585
4247
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
3.0
12.8
74
252
CA1AD
NOMESCO Finland
Orbita CT
11.6
12.8
23
20
A11CC03
ATC
alfacalcidol; systemic
2.7
12.7
88
335
J01CA04
ATC
amoxicillin; systemic
1.3
12.7
2895
26514
CS2P4
NOMESCO Finland
Optic nerve head imaging
6.0
12.7
34
57
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
12.4
1600
13637
C07AB07
ATC
bisoprolol; oral
1.3
12.4
2079
18309
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
1.9
12.3
182
983
E0000UV
ATC
NA
1.3
12.3
1366
11415
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
3.4
12.3
59
177
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.5
12.3
404
2739
H43.2
ICD-10 Finland
Crystalline deposits in vitreous body
9.6
12.2
24
25
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
7.4
12.2
28
38
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
2.7
12.1
84
320
M01AB05
ATC
diclofenac; systemic, rectal
1.3
12.1
2338
20912
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.4
12.0
663
4983
S01ED02
ATC
betaxolol; ophthalmic
3.1
12.0
63
202
F29
ICPC
Eye symptom/complaint other
1.7
11.8
269
1663
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
1.8
11.8
202
1147
K02.1
ICD-10 Finland
Caries of dentine
1.3
11.8
1674
14410
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.5
11.8
388
2633
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
5.9
11.8
32
55
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
3.1
11.7
62
200
C10AA01
ATC
simvastatin; oral
1.3
11.7
1998
17581
CKD60
NOMESCO Finland
Anterior vitrectomy
3.5
11.6
52
148
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
11.6
1411
11915
H30.1
ICD-10 Finland
Disseminated chorioretinal inflammation
+∞
11.5
11
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
4.6
11.3
38
83
T90
ICPC
Diabetes non-insulin dependent
1.3
11.3
888
7053
A12AA04
ATC
calcium carbonate; oral
3.1
11.3
61
200
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
15.0
11.3
18
12
CK2K4
NOMESCO Finland
Red-free imaging of ocular fundus
35.1
11.3
14
*
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.3
11.2
816
6410
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
17.1
11.2
17
10
R01AD09
ATC
mometasone; nasal
1.3
11.1
1363
11497
J02AC01
ATC
fluconazole; systemic
1.3
11.1
1188
9849
XKD00
NOMESCO Finland
Uroflowmetry
1.4
11.1
656
4979
UKC02
NOMESCO Finland
Cystoscopy
1.4
11.1
675
5152
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
2.4
11.1
92
389
H27.0
ICD-10 Finland
Aphakia
8.6
11.0
23
27
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
10.9
1292
10850
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
6.3
10.9
28
45
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.3
10.8
1114
9191
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.2
10.7
1688
14660
K30
ICD-10 Finland
Functional dyspepsia
1.5
10.7
341
2296
J01AA02
ATC
doxycycline; systemic
1.3
10.6
2978
27592
H34.9
ICD-10 Finland
Retinal vascular occlusion, unspecified
60.1
10.6
12
*
N40
ICD-10 Finland
Hyperplasia of prostate
1.3
10.6
871
6959
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.6
10.6
280
1803
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
4.5
10.5
36
81
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
10.5
1461
12499
J01MA12
ATC
levofloxacin; systemic
1.3
10.5
696
5388
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
10.5
1148
9536
1LA04
NOMESCO Finland
NA
110.3
10.4
11
*
CKD45
NOMESCO Finland
Endocryotherapy of retina
+∞
10.4
10
*
S01AX11
ATC
[U] ofloxacin; ophthalmic
1.9
10.4
142
748
H53.2
ICD-10 Finland
Diplopia
2.1
10.3
113
544
M48.0
ICD-10 Finland
Spinal stenosis
1.4
10.3
517
3815
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
1.5
10.2
409
2890
B01AC04
ATC
clopidogrel; oral
1.3
10.2
669
5166
H01.0
ICD-10 Finland
Blepharitis
1.9
10.2
154
841
S01GX01
ATC
cromoglicic acid; ophthalmic
1.4
10.2
525
3897
KMAK
NOMESCO Finland
NA
1.2
10.1
1556
13453
J01FF01
ATC
clindamycin; systemic
1.3
10.1
888
7157
H81
ICPC
Excessive ear wax
1.3
10.0
672
5204
J01FA10
ATC
azithromycin; systemic
1.2
9.9
1760
15452
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
2.2
9.9
102
479
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
9.7
937
7639
G04CA02
ATC
tamsulosin; oral
1.3
9.7
932
7594
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.4
9.7
458
3343
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
3.5
9.7
44
128
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
3.5
9.7
43
123
S29
ICPC
Skin symptom/complaint other
1.4
9.7
611
4686
R06.0
ICD-10 Finland
Dyspnoea
1.3
9.7
975
7998
L04AX01
ATC
azathioprine; systemic
1.9
9.6
130
682
D07AC01
ATC
betamethasone; topical
1.3
9.6
1195
10061
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.5
9.6
352
2445
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.3
9.6
919
7489
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
4.9
9.6
30
62
N02AX02
ATC
tramadol; systemic, rectal
1.2
9.5
1575
13698
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
4.1
9.5
35
85
L28
ICPC
Limited function/disability (L)
1.3
9.5
673
5252
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
10.0
9.5
18
18
127
Kela drug reimbursment
Transplant complication
3.3
9.5
46
141
S01FA02
ATC
scopolamine; ophthalmic
3.4
9.4
44
131
N03AX16
ATC
pregabalin; oral
1.3
9.4
819
6584
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.5
9.4
372
2625
CKC75
NOMESCO Finland
Removal of cerclage from sclera
+∞
9.4
9
*
H31.0
ICD-10 Finland
Chorioretinal scars
+∞
9.4
9
*
H35.1
ICD-10 Finland
Retinopathy of prematurity
+∞
9.4
9
*
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.2
9.3
1329
11364
WX408
NOMESCO Finland
General anesthesy, balanced
1.3
9.3
910
7435
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.3
9.3
711
5613
H21.0
ICD-10 Finland
Hyphaema
6.4
9.2
23
36
CHD00
NOMESCO Finland
Laser trabeculoplasty
2.5
9.2
70
284
Z49.1
ICD-10 Finland
Extracorporeal dialysis
3.1
9.1
47
151
L01
ICPC
Neck symptom/complaint
1.4
9.1
418
3036
CHD99
NOMESCO Finland
Other filtering operation
6.2
9.1
23
37
SPAT1254
SPAT
Administration of medicine
1.3
9.1
585
4501
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
2.7
9.0
58
215
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
9.0
9.0
18
20
SPAT1301
SPAT
No procedures
1.2
9.0
1230
10458
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
9.0
1084
9084
J01MA02
ATC
ciprofloxacin; systemic
1.2
9.0
1468
12734
G04CB02
ATC
dutasteride; oral
1.5
8.9
259
1708
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.3
8.8
696
5516
C08CA13
ATC
lercanidipine; oral
1.4
8.8
534
4067
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
8.6
8.8
18
21
M54.5
ICD-10 Finland
Low back pain
1.3
8.7
1029
8595
H20.8
ICD-10 Finland
Other iridocyclitis
7.2
8.7
20
28
B05DB
ATC
Hypertonic solutions
4.7
8.7
28
60
B05DA
ATC
Isotonic solutions
4.4
8.7
30
69
137
Kela drug reimbursment
Uraemia requiring dialysis
3.9
8.7
34
88
M03BX02
ATC
tizanidine; oral
1.2
8.7
1937
17330
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.3
8.7
1026
8570
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.2
8.7
1140
9643
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.4
8.6
491
3701
G47.3
ICD-10 Finland
Sleep apnoea
1.3
8.6
618
4828
H02.3
ICD-10 Finland
Blepharochalasis
1.6
8.6
239
1561
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
6.1
8.6
22
36
F05
ICPC
Visual disturbance other
2.1
8.5
91
437
H02.4
ICD-10 Finland
Ptosis of eyelid
2.0
8.5
104
527
M79.1
ICD-10 Finland
Myalgia
1.4
8.5
370
2660
H40.19
ICD-10 Finland
Other primary glaucoma with open ventricular angle
6.4
8.5
21
33
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
6.4
8.5
21
33
C02AC05
ATC
moxonidine; oral
1.7
8.4
168
1005
3744
FHL
Pericardial identification surgery with coagulation (includes epi- and intrascleral indications and eg Lincoff catheter)
90.2
8.4
9
*
G04CA52
ATC
tamsulosin and dutasteride; systemic
1.4
8.4
349
2488
3745
FHL
Hard membrane girding, cerclage with coagulation
+∞
8.3
8
*
CKD85
NOMESCO Finland
Removal of subretinal membrane or band
+∞
8.3
8
*
H3602, E103
ICD-10 Finland
NA
+∞
8.3
8
*
H30.8
ICD-10 Finland
Other chorioretinal inflammations
+∞
8.3
8
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.6
8.3
205
1300
SPAT1260
SPAT
Consultation of another employee
1.3
8.3
646
5107
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
1.7
8.3
162
964
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.2
8.3
1189
10145
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
10.7
8.3
15
14
D64.9
ICD-10 Finland
Anaemia, unspecified
1.4
8.3
419
3093
CA1TM
NOMESCO Finland
Calculation of intraocular lens power
2.2
8.3
78
353
Z71.8
ICD-10 Finland
Other specified counselling
1.3
8.2
706
5655
SDA02
NOMESCO Finland
Parodonthologic therapy
1.3
8.2
956
7965
H40
ICD-10 Finland
Glaucoma
2.6
8.2
57
222
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.5
8.2
283
1942
M02AA07
ATC
piroxicam; topical
1.2
8.2
1420
12364
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
3.4
8.2
37
109
C10AA07
ATC
rosuvastatin; oral
1.3
8.1
875
7222
B01AB05
ATC
enoxaparin; parenteral
1.2
8.1
1177
10053
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
8.1
1596
14072
D82
ICPC
Teeth/gum disease
1.3
8.1
918
7623
171
Kela drug reimbursment
Degludekinsuliini
33.4
8.1
10
*
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
33.4
8.1
10
*
H26.3
ICD-10 Finland
Drug-induced cataract
4.2
8.1
29
70
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.3
8.1
995
8342
J05AB01
ATC
aciclovir; systemic
1.3
8.0
674
5389
SAA03
NOMESCO Finland
Extended examination of mouth
1.2
8.0
1077
9121
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.3
8.0
500
3829
A10BB01
ATC
glibenclamide; oral
1.6
7.9
183
1144
C09AA02
ATC
enalapril; systemic
1.3
7.9
833
6854
CJF45
NOMESCO Finland
Removal and implantation of artificial lens in anterior chamber with iridectomy or iridotomy
6.6
7.9
19
29
F99
ICPC
Eye/adnexa disease other
4.0
7.8
29
72
C03AA03
ATC
hydrochlorothiazide; oral
1.4
7.8
412
3066
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.3
7.8
782
6394
R11
ICD-10 Finland
Nausea and vomiting
1.5
7.8
271
1866
M01AE01
ATC
ibuprofen; systemic, rectal
1.2
7.8
3216
30412
25008
ICD-8 Finland
Diabetes mellitus, Complicatio alia definita
15.0
7.7
12
8
R53
ICD-10 Finland
Malaise and fatigue
1.3
7.7
745
6064
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.3
7.7
580
4565
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
1.5
7.7
239
1606
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.4
7.6
331
2375
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.4
7.6
415
3101
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
2.6
7.6
53
206
D07AC13
ATC
mometasone; topical
1.2
7.6
938
7856
N06AX11
ATC
mirtazapine; oral
1.2
7.6
1051
8921
M01AH01
ATC
celecoxib; oral (coxibs)
1.3
7.6
644
5148
C09CA01
ATC
losartan; oral
1.2
7.6
924
7731
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
2.1
7.5
81
391
H53.8
ICD-10 Finland
Other visual disturbances
3.0
7.5
41
139
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
5.4
7.5
21
39
M01AC06
ATC
meloxicam; systemic, rectal
1.2
7.5
1262
10931
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.3
7.5
528
4114
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
1.6
7.4
205
1340
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.5
7.4
214
1413
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
3.7
7.4
30
81
M01AH05
ATC
etoricoxib; oral
1.2
7.4
1871
16846
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
4.0
7.4
27
67
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.2
7.3
919
7708
R05
ICD-10 Finland
Cough
1.3
7.3
654
5265
K03.64
ICD-10 Finland
Dental calculus supragingival
1.3
7.3
699
5677
H13
ICPC
Plugged feeling ear
1.3
7.3
687
5568
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.4
7.3
352
2577
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.2
7.3
1127
9672
H3601, E117
ICD-10 Finland
NA
+∞
7.3
7
*
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
+∞
7.3
7
*
WZA90
NOMESCO Finland
Other doctors statement
1.3
7.3
681
5516
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
1.8
7.2
120
682
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.3
7.2
486
3762
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
30.0
7.1
9
*
CH2X4
NOMESCO Finland
Optical coherence tomography (OCT) of iris and iridocorneal angle
30.0
7.1
9
*
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
2.8
7.1
42
149
TK800
NOMESCO Finland
Hemodialysis
2.2
7.1
66
300
M14.6*E10.6
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic neuropathic
20.0
7.1
10
5
Z01.8
ICD-10 Finland
Other specified special examinations
1.3
7.1
689
5602
R01AD12
ATC
fluticasone furoate; nasal
1.3
7.1
735
6026
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
5.6
7.0
19
34
NGQ20
NOMESCO Finland
Amputation of lower leg
3.7
7.0
28
75
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.2
7.0
1024
8726
R60.0
ICD-10 Finland
Localized oedema
1.3
7.0
425
3234
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
3.1
7.0
35
112
C09AA05
ATC
ramipril; oral
1.2
7.0
1047
8944
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.4
7.0
329
2403
PF1BT
NOMESCO Finland
Extensive PTA of arteries of knee, lower leg and ankle
3.5
7.0
30
86
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.4
6.9
339
2492
B03XA02
ATC
darbepoetin alfa; parenteral
2.2
6.9
65
298
M10
ICD-10 Finland
Gout
1.6
6.9
158
983
A01
ICPC
Pain general/multiple sites
1.5
6.9
260
1817
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
0.0
6.8
*
170
S01EB01
ATC
pilocarpine; ophthalmic
2.8
6.8
40
142
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
3.8
6.7
26
68
RK321
NOMESCO Finland
NA
16.7
6.7
10
6
G44.2
ICD-10 Finland
Tension-type headache
1.4
6.7
367
2750
H54.3
ICD-10 Finland
Mild or no visual impairment, binocular
7.2
6.7
15
21
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.3
6.7
561
4477
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
2.7
6.7
41
151
R3120
NOMESCO Finland
Training in mobility skills
22.5
6.7
9
*
CHD35
NOMESCO Finland
Laser goniopuncture
3.9
6.7
25
64
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
3.0
6.6
35
117
Z49.0
ICD-10 Finland
Preparatory care for dialysis
3.0
6.6
35
117
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.2
6.6
1040
8926
CFW99
NOMESCO Finland
Other operation on conjunctiva
5.9
6.6
17
29
H11.3
ICD-10 Finland
Conjunctival haemorrhage
1.7
6.6
137
835
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.3
6.6
569
4556
SPAT1211
SPAT
Application of soft bandage
1.4
6.6
319
2340
H44.1
ICD-10 Finland
Other endophthalmitis
12.2
6.6
11
9
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
3.5
6.6
28
80
J01CE02
ATC
phenoxymethylpenicillin; oral
1.2
6.6
2246
20686
CFB00
NOMESCO Finland
Suture of conjunctiva
8.7
6.5
13
15
K85
ICPC
Elevated blood pressure
1.3
6.5
585
4708
C07AB02
ATC
metoprolol; systemic
1.2
6.5
906
7675
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.4
6.5
251
1763
I50.9
ICD-10 Finland
Heart failure, unspecified
1.3
6.5
629
5110
H03AA01
ATC
levothyroxine sodium; systemic
1.2
6.5
812
6802
A04
ICPC
Weakness/tiredness general
1.3
6.5
442
3423
A10BB07
ATC
glipizide; oral
2.1
6.5
64
300
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.3
6.5
661
5410
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.4
6.4
363
2731
L13
ICPC
Hip symptom/complaint
1.3
6.4
597
4829
S97
ICPC
Chronic ulcer skin
1.5
6.4
202
1363
2507B
ICD-9 Finland
Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICAT ALIA ,TYYPPI I]
14.3
6.4
10
7
V03AE02
ATC
sevelamer; oral
4.9
6.3
19
39
H28.0*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic cataract
8.1
6.3
13
16
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
2.1
6.3
67
322
A10AD04
ATC
insulin lispro; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
5.2
6.3
18
35
L82
ICD-10 Finland
Seborrhoeic keratosis
1.3
6.3
538
4304
CKC65
NOMESCO Finland
Removal of buckling implant from sclera
+∞
6.2
6
*
H3603, E1100
ICD-10 Finland
NA
+∞
6.2
6
*
H3601, E119
ICD-10 Finland
NA
+∞
6.2
6
*
H31.4
ICD-10 Finland
Choroidal detachment
+∞
6.2
6
*
371
Kela drug reimbursment
Degludekinsuliini
+∞
6.2
6
*
37600
ICD-8 Finland
Detachment of retina, Primaria
+∞
6.2
6
*
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
1.6
6.2
167
1085
S01AD03
ATC
aciclovir; ophthalmic
1.7
6.2
125
754
H40.22
ICD-10 Finland
Chronic glaucoma with closed ventricular angle
2.9
6.2
36
126
J01DA01
ATC
[U] cefalexin; systemic
1.2
6.2
2238
20656
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
2.6
6.2
42
164
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
1.4
6.2
327
2434
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
3.3
6.2
28
84
2500X
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,NUD]
4.8
6.2
19
40
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
1.8
6.2
100
566
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.4
6.2
344
2585
-44
ICPC
Preventive immunization/medic
1.4
6.2
320
2376
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
1.9
6.2
84
449
N17.9
ICD-10 Finland
Acute renal failure, unspecified
1.6
6.2
136
843
K59.09
ICD-10 Finland
Constipation, unspecified
1.5
6.2
221
1534
L04AA01
ATC
[U] ciclosporin; systemic
2.4
6.2
48
202
L05
ICPC
Flank/axilla symptom/complaint
1.5
6.1
169
1106
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
5.3
6.1
17
32
H54.6
ICD-10 Finland
Moderate visual impairment, monocular
5.3
6.1
17
32
A02BA02
ATC
ranitidine; systemic
1.2
6.1
765
6404
M45
ICD-10 Finland
Ankylosing spondylitis
2.2
6.1
57
262
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.0
6.1
75
385
SPAT1097
SPAT
Recording of ECG
1.3
6.1
584
4736
R35
ICD-10 Finland
Polyuria
1.5
6.1
220
1528
N06AB06
ATC
sertraline; oral
1.4
6.1
255
1822
H40.6
ICD-10 Finland
Glaucoma secondary to drugs
12.5
6.1
10
8
SPAT1229
SPAT
Assessment of need for aid
1.4
6.1
330
2470
205
Kela drug reimbursment
Chronic hypertension
1.2
6.0
1249
10992
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
8.6
6.0
12
14
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
2.2
6.0
56
257
J31.0
ICD-10 Finland
Chronic rhinitis
1.5
6.0
199
1355
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
1.5
6.0
180
1202
Mortality – FinRegistry
↥Association
Association between endpoint MACULA_NAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MACULA_NAS | 0.835 [0.77, 0.9] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.321 |
During the follow-up period (1.1.1998 — 31.12.2019), 5005 out of 18044 females with MACULA_NAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MACULA_NAS | 0.831 [0.76, 0.91] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 3981 out of 12716 males with MACULA_NAS died.
Mortality risk
Mortality risk for people of age
years, who have MACULA_NAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.134% |
| 5 | 0.476% | 0.925% |
| 10 | 1.182% | 2.498% |
| 15 | 2.459% | 4.884% |
| 20 | 4.356% | 8.585% |
Relationships between endpoints
↥Index endpoint: MACULA_NAS – Degenerative macular diseases
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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