Acute hepatitis B

AB1_HEPATITIS_B

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B16
  • Hospital discharge: ICD-9 070[2-3]
  • Cause of death: ICD-10 B16
  • Cause of death: ICD-9 070[2-3]

2 out of 7 registries used, show all original rules.

159

4. Check minimum number of events

None

159

5. Include endpoints

None

159

6. Filter based on genotype QC (FinnGen only)

159

Control definitions (FinnGen only)

Control exclude
AB1_VIRAL_HEPATITIS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
B15-B19
Name in latin
Hepatitis B acuta

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1640 629 974
Only index persons 1328 541 787
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.03
Only index persons 0.03 0.02 0.03
Median age at first event (years)
Whole population 30.79 27.28 32.85
Only index persons 30.02 26.63 32.34

-FinnGen-

Key figures

All Female Male
Number of individuals 159 78 81
Unadjusted period prevalence (%) 0.03 0.03 0.04
Median age at first event (years) 32.62 28.42 36.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
146
Matched controls
1459
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B16.9
ICD-10 Finland
Acute hepatitis B without delta-agent and without hepatic coma
+∞
108.2
90
*
0703A
ICD-9 Finland
Viral hepatitis B without mention of hepatic coma
+∞
52.3
47
*
B18.2
ICD-10 Finland
Chronic viral hepatitis C
+∞
39.4
36
*
B18.1
ICD-10 Finland
Chronic viral hepatitis B without delta-agent
+∞
26.9
25
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
11.4
23.7
47
58
F15.2
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome
+∞
20.3
19
*
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
45.9
16.8
20
5
F19.29
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances UNS
89.3
14.9
16
*
N05BA01
ATC
diazepam; systemic, rectal
5.7
12.6
39
88
F15.1
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, harmful use
+∞
11.6
11
*
N05AH04
ATC
quetiapine; oral
4.3
10.7
44
133
F19.21
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances currently independent but staying in a controlling environment
+∞
10.5
10
*
3049X
ICD-9 Finland
Drug dependence, Unspecified drug dependence
+∞
10.5
10
*
P19
ICPC
Drug abuse
43.3
10.1
12
*
3044A
ICD-9 Finland
Drug dependence, Amphetamine and other psychostimulant dependence
+∞
9.5
9
*
F15.5
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, psychotic disorder
+∞
9.5
9
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
6.6
9.1
23
40
N05CD07
ATC
temazepam; oral
5.0
8.6
28
66
F11.22
ICD-10 Finland
Addiction-induced dependence is currently independent but uses substitute intermittent medication
95.3
8.5
9
*
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
95.3
8.5
9
*
F19.20
ICD-10 Finland
Addiction relationship caused by several drugs in combination and by other psychoactive substances currently independent
95.3
8.5
9
*
F19.25
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances continuously used
95.3
8.5
9
*
F19.24
ICD-10 Finland
Addiction relationship caused by several drugs in combination and by other psychoactive substances active addiction
+∞
8.4
8
*
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
+∞
8.4
8
*
F11.25
ICD-10 Finland
Relationship caused by opiates continuously used
+∞
8.4
8
*
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
18.5
8.2
12
7
T36
ICD-10 Finland
Poisoning by systemic antibiotics
8.2
7.9
17
23
F19.30
ICD-10 Finland
Withdrawal symptoms caused by several drugs in combination and by other psychoactive substances uncomplicated
+∞
7.3
7
*
0705A
ICD-9 Finland
Viral hepatitis, Other specified viral hepatitis without mention of hepatic coma
+∞
7.3
7
*
F13.25
ICD-10 Finland
Addiction caused by sedative and hypnotic continuous use
42.1
6.8
8
*
F60.2
ICD-10 Finland
Dissocial personality disorder
42.1
6.8
8
*
N05BA04
ATC
oxazepam; oral
2.9
6.8
47
206
N05BA02
ATC
chlordiazepoxide; systemic
9.4
6.7
13
15
K05.31
ICD-10 Finland
Periodontitis pronounced
4.7
6.7
22
53
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
15.2
6.5
10
7
F19.2
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, dependence syndrome
72.9
6.5
7
*
A56.0
ICD-10 Finland
Chlamydial infection of lower genitourinary tract
19.0
6.3
9
5
B19.9
ICD-10 Finland
Unspecified viral hepatitis without hepatic coma
+∞
6.3
6
*
O98.4
ICD-10 Finland
Viral hepatitis complicating pregnancy, childbirth and the puerperium
+∞
6.3
6
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
4.2
6.3
23
62

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
66
202
4.88
20.67
2.3
1.7
—
—
—
0
0
26
34
8.95
19.29
11.6
1.8
—
—
—
0
0
44
101
5.64
19.23
2.1
1.6
—
—
—
0
0
21
21
11.37
18.90
1.4
1.2
—
—
—
0
0
71
250
4.32
18.17
2.6
1.9
—
—
—
0
0
54
167
4.38
16.22
2.3
1.8
—
—
—
0
0
15
0
+∞
15.89
2.4
0.0
—
—
—
0
0
19
23
9.25
14.82
1.1
1.1
—
—
—
0
0
21
31
7.65
13.95
1.1
1.1
—
—
—
0
0
18
26
7.68
12.13
8.3
1.6
—
—
—
0
0
24
48
5.71
11.90
1.5
1.4
170.5
274.0
miu/ml
—
8
30
70
323
3.09
10.77
8.9
7.2
—
—
—
0
0
21
42
5.61
10.37
7.4
1.4
—
—
—
0
0
9
0
+∞
9.46
1.0
0.0
—
—
—
0
0
22
52
4.75
8.99
7.7
1.4
—
—
—
0
0
77
412
2.68
8.54
9.2
5.6
—
—
—
0
0
97
585
2.69
8.40
9.0
6.0
0.7
0.7
%
0.20
91
547
76
409
2.64
8.27
2.3
1.9
94.1
92.5
pmol/l
0.13
44
233
22
56
4.40
8.19
7.8
1.4
—
—
—
0
0
22
56
4.40
8.19
7.8
1.4
—
—
—
0
0
22
56
4.40
8.19
7.8
1.4
—
—
—
0
0
98
606
2.61
7.88
9.0
6.0
3.1
2.8
%
0.67
92
568
94
572
2.57
7.78
11.5
9.0
0.0
0.0
e9/l
0.48
79
469
21
56
4.17
7.36
8.0
1.4
—
—
—
0
0
98
619
2.52
7.34
8.7
5.9
55.5
57.4
%
0.75
93
587
101
648
2.53
7.29
9.0
6.2
0.0
0.0
e9/l
0.21
87
576
101
648
2.53
7.29
9.0
6.2
0.6
0.6
e9/l
0.02
86
573
103
667
2.55
7.29
9.2
6.5
0.2
0.2
e9/l
0.06
88
602
103
668
2.54
7.25
8.9
6.2
1.8
2.0
e9/l
0.38
89
602
10
5
21.19
7.23
1.1
1.0
—
—
—
0
0
10
6
17.65
6.84
1.1
1.2
—
—
—
0
0
65
360
2.36
6.28
3.3
2.2
—
—
—
0
0
109
757
2.40
6.14
14.5
10.2
3.7
4.0
e9/l
1.27
97
670
16
40
4.34
6.06
1.2
1.3
—
—
—
0
0
17
46
4.02
5.82
1.8
1.3
—
—
—
0
0
9
7
13.52
5.65
5.9
1.1
—
—
—
0
0
81
509
2.21
5.64
6.1
5.8
1.2
1.2
mmol/l
0.21
76
469
129
992
2.59
5.40
11.6
8.0
86.5
76.4
u/l
0.77
122
932
62
357
2.21
5.29
4.8
4.5
7.4
7.4
ph
—
6
68
49
260
2.28
5.07
2.9
3.4
—
—
—
0
0
25
103
2.69
4.40
7.2
6.3
—
—
—
0
0
52
302
2.07
4.20
6.7
4.3
—
—
—
0
0
68
436
1.98
4.17
7.7
8.1
1.2
1.1
inr
0.30
17
134
64
404
1.98
4.08
5.0
3.4
14.0
22.2
e6/l
0.65
40
287
47
266
2.09
4.05
1.8
1.7
1.1
1.0
mg/l
0.23
39
211
34
169
2.29
4.03
2.0
2.2
—
—
—
0
0
44
246
2.09
3.90
3.1
2.0
3.0
3.2
mg/l
0.19
38
211
53
319
1.99
3.83
4.5
2.5
—
—
—
0
0
25
111
2.49
3.79
4.1
4.1
—
—
—
0
0
53
322
1.97
3.72
4.5
2.7
0.2
0.6
e6/l
1.20
35
237
58
366
1.92
3.63
7.1
3.0
7.5
8.3
mmol/l
0.59
51
319
150
1339
3.12
3.60
20.1
13.4
139.2
139.7
mmol/l
2.12
145
1310
100
755
1.87
3.54
4.4
3.8
—
291.0
—
0
12
97
727
1.86
3.49
5.5
4.5
7.0
6.6
mmol/l
0.41
92
679
150
1345
3.03
3.44
20.7
13.5
4.0
4.0
mmol/l
0.04
145
1313
17
66
2.76
3.34
1.2
1.1
—
—
—
0
0
55
350
1.87
3.31
4.4
3.0
23.9
204.8
e6/l
0.49
38
268
59
389
1.82
3.15
3.9
3.5
2.3
2.3
mmol/l
1.11
50
349
41
242
1.94
3.07
1.7
1.5
18.3
20.6
nmol/l
0.45
34
205
31
167
2.06
2.99
1.2
1.2
—
—
—
0
0
27
139
2.14
2.92
1.9
1.7
—
—
—
0
0
32
179
1.99
2.78
2.2
1.7
1044.3
1328.1
nmol/l
1.01
25
138
16
68
2.50
2.65
2.4
2.4
167.6
84.3
ng/l
0.52
16
60
24
123
2.12
2.62
3.3
1.7
—
—
—
0
0
5
7
7.33
2.56
1.0
1.6
—
—
—
0
0
80
609
1.63
2.39
3.2
3.3
0.0
0.0
estimate
—
9
115
32
189
1.87
2.37
3.6
2.7
2.5
2.4
mmol/l
0.61
26
168
35
218
1.78
2.18
5.9
3.2
221.7
133.5
ng/l
0.23
30
146
80
619
1.59
2.17
3.3
3.3
0.0
0.0
estimate
—
8
109
24
133
1.95
2.14
1.3
1.4
—
—
—
0
0
79
611
1.58
2.14
4.9
4.4
0.0
0.0
estimate
—
9
117
43
290
1.66
2.02
1.3
1.4
2.6
2.6
g/l
0.01
28
193
9
196
0.43
2.02
1.1
1.4
—
—
—
0
0
101
840
1.55
1.90
4.2
3.8
—
—
—
0
0
138
1244
1.83
1.81
24.2
12.6
40.4
40.8
%
0.21
116
988
9
36
2.59
1.77
3.9
2.9
—
—
—
0
0
0
46
0.00
1.74
0.0
1.5
—
—
—
0
0
5
13
3.93
1.73
1.4
1.4
—
—
—
0
0
151
1419
2.27
1.71
22.3
14.3
73.4
76.6
umol/l
0.84
151
1419
131
1170
1.68
1.70
5.0
4.5
1.9
1.8
mu/l
0.03
122
1083
7
25
2.88
1.67
1.1
1.4
—
—
—
0
0
39
272
1.57
1.58
7.0
3.6
1.0
1.0
kg/l
—
5
36
107
922
1.49
1.54
3.9
3.4
—
—
—
0
0
143
1326
1.78
1.37
19.5
12.5
24.4
22.3
mg/l
0.35
123
1011
149
1401
2.01
1.33
15.9
11.5
—
—
—
0
0
9
43
2.16
1.32
1.4
1.3
—
—
—
0
0
18
108
1.75
1.29
1.4
1.3
—
—
—
0
0
108
960
1.39
1.12
3.7
3.8
11.9
10.0
mm/h
0.80
101
894
12
67
1.86
1.08
7.6
4.5
24.9
24.8
mmol/l
0.03
12
67
13
76
1.77
1.02
1.4
1.3
—
—
—
0
0
40
308
1.40
0.99
1.3
1.3
1.8
1.7
u/ml
0.03
13
94
0
31
0.00
0.97
0.0
5.6
—
27.8
—
0
18
17
114
1.55
0.83
3.1
2.6
1.5
1.8
%
0.60
17
103
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
20
141
1.48
0.79
1.3
1.2
—
—
—
0
0
0
26
0.00
0.79
0.0
1.4
—
—
—
0
0
0
26
0.00
0.79
0.0
1.4
—
—
—
0
0
0
28
0.00
0.77
0.0
4.6
—
—
—
0
0
0
28
0.00
0.77
0.0
1.6
—
—
—
0
0
31
240
1.36
0.75
3.3
2.6
9.4
8.3
e6/l
0.07
25
209
5
24
2.12
0.75
1.6
1.3
—
—
—
0
0
48
570
0.77
0.74
2.2
2.7
—
—
—
0
0
29
225
1.35
0.70
3.4
2.4
523.7
583.6
mosm/kgh2o
0.62
23
190
16
112
1.48
0.66
6.9
6.8
94.6
95.0
%
0.11
16
107
19
138
1.43
0.66
1.2
1.2
—
—
—
0
0
58
504
1.24
0.60
2.0
1.9
—
—
—
0
0
8
55
1.48
0.57
1.1
1.1
—
—
—
0
0
19
144
1.36
0.53
1.7
1.4
—
—
—
0
0
10
67
1.53
0.51
1.0
2.6
—
—
—
0
0
7
48
1.48
0.47
1.4
1.2
—
—
—
0
0
7
50
1.42
0.45
1.7
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
3.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
5
35
1.44
0.39
1.0
1.6
—
—
—
0
0
5
35
1.44
0.39
1.4
1.2
—
—
—
0
0
11
80
1.40
0.39
1.2
1.1
—
—
—
0
0
12
157
0.75
0.38
1.6
1.6
—
—
—
0
0
5
76
0.65
0.36
1.2
3.7
—
7.4
—
0
8
38
333
1.19
0.35
4.3
3.3
106.1
273.3
mg/l
0.38
26
220
12
92
1.33
0.33
1.4
1.5
—
—
—
0
0
132
1277
1.20
0.32
4.4
4.1
6.2
5.9
mmol/l
0.83
123
1186
12
93
1.31
0.31
2.1
4.4
—
—
—
0
0
7
55
1.29
0.30
1.9
2.1
—
—
—
0
0
7
56
1.26
0.30
1.4
3.5
—
—
—
0
0
139
1355
1.21
0.28
4.8
4.5
2.7
2.8
mmol/l
0.77
130
1265
39
352
1.14
0.26
5.5
4.0
14.0
11.9
mg/mmol
0.14
28
228
39
352
1.14
0.26
1.8
1.5
—
—
—
0
0
9
75
1.21
0.25
1.7
3.6
122.8
130.5
g/l
—
9
75
9
77
1.18
0.25
4.4
4.1
4.7
4.7
pmol/l
—
9
66
7
91
0.76
0.23
1.3
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
222.1
—
0
10
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
33.7
—
0
13
9
111
0.80
0.21
1.1
1.2
—
17.4
—
0
7
9
112
0.79
0.21
1.9
1.4
—
—
—
0
0
6
49
1.23
0.20
2.0
1.5
—
—
—
0
0
124
1208
1.12
0.20
5.8
5.3
39.0
39.5
mmol/mol
0.25
119
1146
127
1298
0.89
0.18
3.9
3.7
1.5
1.3
mmol/l
0.94
121
1210
5
69
0.72
0.17
2.2
2.8
2.3
1.4
%
—
5
69
34
368
0.90
0.16
3.4
2.9
—
—
—
0
0
15
172
0.86
0.16
1.5
1.4
—
—
—
0
0
6
75
0.79
0.16
4.5
7.8
24.5
24.2
mmol/l
—
6
70
34
314
1.11
0.16
2.3
3.3
—
—
—
0
0
9
80
1.13
0.15
1.9
1.7
—
—
—
0
0
37
345
1.09
0.14
3.2
2.6
330.6
7370.9
umol/l
1.73
32
307
29
267
1.11
0.14
2.2
2.8
0.6
0.7
ug/l
0.58
18
155
26
238
1.11
0.14
1.3
1.2
89.6
35.2
iu/ml
—
5
75
11
94
1.18
0.13
2.3
3.8
—
—
—
0
0
14
124
1.14
0.11
1.7
2.1
366.1
372.5
nmol/l
0.04
14
112
5
43
1.17
0.10
2.6
1.8
—
59.9
—
0
12
12
107
1.13
0.09
1.2
1.2
—
—
—
0
0
8
76
1.06
0.07
1.0
1.1
—
—
—
0
0
11
121
0.90
0.06
2.2
2.2
—
6.0
—
0
6
35
336
1.05
0.06
3.5
3.5
0.0
0.0
estimate
—
7
109
43
444
0.96
0.05
2.6
3.5
12.1
30.5
ng/l
2.38
20
271
135
1341
1.04
0.03
4.4
4.2
4.6
4.7
mmol/l
0.66
126
1263
23
231
0.99
0.00
1.4
1.2
31.0
12.2
u/ml
—
5
92
45
449
1.00
0.00
3.4
4.3
1.5
2.5
ug/l
0.76
36
408
28
283
0.99
0.00
4.3
2.5
—
—
—
0
0
33
327
1.01
0.00
5.2
5.3
—
—
—
0
0
11
105
1.05
0.00
4.8
3.0
—
—
—
0
0
134
1338
1.01
0.00
4.3
4.1
1.3
1.4
mmol/l
2.51
126
1249
0
6
0.00
0.00
0.0
2.5
—
0.8
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
2.9
—
0
6
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.9
—
13.2
—
0
9
0
6
0.00
0.00
0.0
2.7
—
5.6
—
0
6
0
6
0.00
0.00
0.0
12.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.8
—
13.5
—
0
6
6
62
0.97
0.00
1.3
4.1
26.0
24.5
mmol/l
—
6
62
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
74
0.94
0.00
2.4
4.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
6.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
7.8
—
0
8
5
52
0.96
0.00
3.4
4.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
2456.4
—
0
7
0
7
0.00
0.00
0.0
2.6
—
52.5
—
0
7
0
7
0.00
0.00
0.0
11.4
—
—
—
0
0
0
5
0.00
0.00
0.0
4.0
—
25.4
—
0
5
5
57
0.87
0.00
1.0
4.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_HEPATITIS_B and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
AB1_HEPATITIS_B 3.56 [2.5, 5.06] < 0.001
Birth year 0.986 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 128 out of 555 males with AB1_HEPATITIS_B died.

Mortality risk

Mortality risk for people of age

years, who have AB1_HEPATITIS_B.

N-year risk Females Males
1 No data 0.522%
5 No data 4.322%
10 No data 10.091%
15 No data 17.924%
20 No data 29.368%

Relationships between endpoints

Index endpoint: AB1_HEPATITIS_B – Acute hepatitis B

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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