Shigellosis

AB1_SHIGELLOSIS

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A03 Hospital discharge: ICD-9 — 004. Hospital discharge: ICD-8 — 004[0] Cause of death: ICD-10 — A03 Cause of death: ICD-9 — 004. Cause of death: ICD-8 — 004[0] 2 out of 7 registries used, show all original rules.	119
4. Check minimum number of events None	119
5. Include endpoints None	119
6. Filter based on genotype QC (FinnGen only)	119

Control definitions (FinnGen only)

Control exclude: AB1_INTESTINAL_INFECTIONS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_SHIGELLOSIS
CONTROL_EXCLUDE	AB1_INTESTINAL_INFECTIONS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A03
HD_ICD_9	004.
HD_ICD_8	004[0]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A03
COD_ICD_9	004.
COD_ICD_8	004[0]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Shigellosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	973	504	461
Only index persons	826	445	381
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	39.41	39.06	39.80
Only index persons	36.35	36.63	36.02

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	119	65	54
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	42.26	38.77	46.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
109: Matched controls
1091

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A03.9

ICD-10 Finland

Shigellosis, unspecified

+∞

43.7

A03.3

ICD-10 Finland

Shigellosis due to Shigella sonnei

+∞

20.4

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

12.7

20.2

A03.0

ICD-10 Finland

Shigellosis due to Shigella dysenteriae

+∞

17.1

00920

ICD-8 Finland

Diarrhoeal disease, Gastroenteritis (acuta) (infectiosa)

+∞

8.4

A03.1

ICD-10 Finland

Shigellosis due to Shigella flexneri

+∞

7.4

A03.8

ICD-10 Finland

Other shigellosis

+∞

7.4

0049X

ICD-9 Finland

Shigellosis, unspecified

+∞

6.3

J01MA02

ATC

ciprofloxacin; systemic

2.8

6.1

251

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42529406) Shigella sp [Presence] in Stool by Culture

11.38

18.45

3.2

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

8.85

12.62

2.1

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

8.85

12.62

2.1

1.1

—

(3025941) Bacteria identified in Stool by Culture

6.52

12.16

1.5

1.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

5.19

7.68

2.6

1.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

4.33

7.15

2.5

1.4

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

6.73

6.06

1.8

1.3

—

(3023368) Bacteria identified in Blood by Culture

202

2.67

5.73

6.8

4.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

4.46

3.97

1.0

2.9

—

(42870588) Differential panel, method unspecified - Blood

307

2.08

3.63

6.5

5.3

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

388

2.03

3.53

7.1

4.9

1.2

mmol/l

1.63

357

(3018095) Leukocytes [#/volume] in Urine

305

2.03

3.38

4.5

3.2

65.6

50.6

e6/l

0.19

201

(3007853) Bacteria identified in Skin by Aerobe culture

2.63

3.37

1.9

1.3

—

(3013115) Eosinophils [#/volume] in Blood

496

2.00

3.34

6.8

6.1

0.2

e9/l

0.18

440

(3002030) Lymphocytes/100 leukocytes in Blood

462

1.96

3.22

7.2

5.8

27.8

28.6

0.24

434

(3037467) Urinalysis macro (dipstick) panel - Urine

619

2.04

3.21

5.1

3.4

—

(3006315) Basophils [#/volume] in Blood

482

1.96

3.19

6.7

5.7

0.0

e9/l

0.00

424

(3019198) Lymphocytes [#/volume] in Blood

494

1.94

3.11

6.8

5.7

1.9

1.8

e9/l

0.16

439

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

414

1.91

2.99

9.1

5.6

1.2

mmol/l

1.15

355

(3001604) Monocytes [#/volume] in Blood

481

1.90

2.94

6.8

5.7

0.6

e9/l

0.05

421

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

8.63

2.77

6.0

8.8

11.3

9.9

mg/l

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.97

2.73

2.0

1.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.58

6.6

1.8

—

(3021788) Differential panel - Synovial fluid

5.68

2.57

1.3

1.4

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

4.01

2.51

2.1

2.5

1.6

1.5

mg/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

134

2.10

2.51

2.2

1.9

—

(3007164) IgA [Mass/volume] in Serum or Plasma

213

1.91

2.47

1.5

1.3

3.1

2.4

g/l

0.98

136

(3037522) Nuclear Ab [Titer] in Serum

120

2.14

2.47

1.3

584.0

365.9

titre

—

(40760892) CBC W Ordered Manual Differential panel - Blood

222

1.89

2.44

4.9

6.0

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

308

1.80

2.40

2.0

1.8

95.8

98.5

pmol/l

0.13

159

(3022806) Fractional oxyhemoglobin in Capillary blood

6.46

2.39

1.8

1.3

89.1

91.1

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

6.46

2.39

1.4

2.0

88.4

86.4

—

(3002582) Erythrocytes [#/volume] in Urine

259

1.82

2.32

4.1

2.7

13.1

312.3

e6/l

0.59

188

(3000991) Gas panel - Venous blood

2.51

2.32

7.9

7.0

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

729

1.88

2.30

9.3

6.8

82.1

76.1

u/l

0.76

681

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.67

2.26

7.7

1.7

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

3.85

2.18

1.9

1.4

—

(3021589) Normoblasts [#/volume] in Blood

416

1.71

2.16

10.2

9.1

0.0

e9/l

0.50

334

(3013650) Neutrophils [#/volume] in Blood by Automated count

562

1.71

2.12

12.3

10.3

4.2

4.0

e9/l

0.24

493

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

103

895

2.12

2.11

16.2

10.7

86.4

85.6

ml/min/173m2

0.12

721

(3030467) Casts [#/volume] in Urine by Automated count

232

1.79

2.10

3.5

2.6

0.2

0.3

e6/l

0.37

163

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

5.16

2.09

1.0

1.2

—

(3044941) Cell count panel - Synovial fluid

5.16

2.09

1.2

1.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.31

2.08

2.3

1.6

—

(3032080) INR in Blood by Coagulation assay

320

1.71

2.06

13.7

6.5

1.2

1.1

inr

0.16

(3042936) Bacteria identified in Isolate by Culture

122

1.99

2.01

4.2

1.7

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

3.89

1.96

2.5

1.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.53

1.91

1.1

3.0

—

(3044640) Blood type and Crossmatch panel - Blood

264

1.71

1.90

2.2

2.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.09

1.86

2.2

1.8

—

(3018418) pH of Serum or Plasma

257

1.70

1.85

7.6

3.8

7.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.06

1.81

2.2

1.6

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.27

1.79

3.8

6.6

0.2

0.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

107

958

2.16

1.77

21.3

11.1

26.3

20.6

mg/l

0.97

723

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.45

1.77

2.7

1.3

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

3.03

1.75

1.6

1.2

—

(40758558) Short blood count panel - Blood

235

1.69

1.74

10.4

6.8

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

193

1.74

2.1

1.5

1.4

1.2

mg/l

0.13

153

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

3.27

1.68

1.7

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

3.27

1.68

1.0

1.1

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

2.19

1.67

15.1

3.1

57.8

68.3

ml/min/173m2

—

(3012544) pH of Venous blood

2.19

1.67

6.2

3.9

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.68

1.63

1.4

—

(3000494) Fungus identified in Specimen by Culture

108

1.90

1.62

1.4

1.5

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

197

1.70

1.61

3.2

3.0

1095.5

875.7

ng/l

0.25

170

(3017181) Myelocytes/100 leukocytes in Blood

2.12

1.55

4.2

6.3

0.4

1.0

—

(3014007) Fractional oxyhemoglobin in Arterial blood

2.33

1.51

5.4

7.3

90.1

93.6

—

(3013707) Erythrocyte sedimentation rate by Westergren method

705

1.59

1.48

4.1

3.6

16.1

9.6

mm/h

1.99

651

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

466

1.53

1.46

8.4

6.3

10.9

11.6

umol/l

0.21

443

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

2.82

1.45

1.2

1.7

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

3.21

1.45

1.4

1.1

—

(3005033) Fetal Nuchal fold Thickness US

3.21

1.45

1.2

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

3.21

1.45

1.2

1.4

—

(36304419) Bacteria [Presence] in Urine

230

1.60

1.41

2.8

2.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

154

1.70

1.40

2.0

1.6

—

(3003694) ABO and Rh group [Type] in Blood

257

1.57

1.39

1.6

1.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

138

1.73

1.38

2.1

2.5

0.4

1.3

e6/l

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

3.02

1.37

1.2

1.5

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

3.02

1.37

1.2

1.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

704

1.53

1.31

3.9

3.3

—

(40768797) Stomach Pathology biopsy report

108

1.79

1.31

1.4

1.3

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

106

969

1.86

1.29

21.9

12.1

139.2

139.9

mmol/l

1.94

101

937

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

2.31

1.27

1.8

1.6

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.14

1.26

3.9

4.5

25.2

24.7

mmol/l

—

(3000492) Spirometry study

1.85

1.26

1.5

1.3

—

(3015736) pH of Urine

345

1.49

1.24

4.6

3.1

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

176

1.61

1.24

1.2

1.3

9.3

22.5

iu/ml

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

730

1.51

1.22

3.6

14.3

14.7

pmol/l

0.70

669

(3023103) Potassium [Moles/volume] in Serum or Plasma

106

973

1.82

1.21

22.1

12.2

3.9

4.0

mmol/l

0.96

101

941

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.18

1.21

2.4

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

403

1.46

1.21

4.1

3.5

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

145

1.63

1.16

3.2

2.9

1572.9

125.2

ng/l

0.43

100

(3005322) IgE [Units/volume] in Serum or Plasma

2.05

1.15

1.0

1.2

210.8

187.1

u/ml

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.07

1.14

2.0

2.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.07

1.14

3.5

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.78

1.14

4.5

3.1

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

198

1.54

1.11

4.9

3.1

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

225

1.51

1.10

1.5

1.2

10.0

1.2

u/ml

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.03

1.06

5.9

7.2

0.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

183

1.54

1.06

3.3

2.0

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.99

1.05

5.9

7.1

1.0

1.6

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

2.33

1.04

1.2

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

2.33

1.04

1.2

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

2.33

1.04

1.2

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

2.33

1.04

1.2

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

300

1.45

1.04

4.1

2.8

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

134

1.59

1.00

1.6

1.9

1.3

1.4

0.36

121

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

126

1.60

0.99

2.1

2.7

2.4

2.8

e6/l

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.00

0.99

1.4

1.5

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

696

1.40

0.94

3.5

2.9

51.3

44.3

u/l

0.26

662

(3034770) Mitochondria Ab [Titer] in Serum

2.20

0.93

1.5

1.1

—

(3035350) Ketones [Presence] in Urine by Test strip

439

1.37

0.91

4.6

3.2

0.0

estimate

0.00

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.12

0.90

1.0

1.3

0.2

0.3

g/l

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.12

0.90

1.3

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.88

0.88

1.5

1.8

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.63

0.86

3.1

1.8

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

892

1.47

0.85

4.2

1.8

1.9

mu/l

0.21

812

(3019225) pH of Specimen

1.68

0.85

1.9

4.1

—

(40768804) Tissue Pathology biopsy report

357

1.37

0.85

2.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

899

1.43

0.75

16.2

11.7

39.9

40.6

0.48

701

(3028707) Methadone [Presence] in Urine by Screen method

2.04

0.73

4.0

1.6

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.75

0.71

2.4

2.1

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.75

0.71

4.6

2.9

23.8

25.2

mmol/l

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

199

1.39

0.70

1.8

1.6

—

(3009261) Glucose [Presence] in Urine by Test strip

454

1.30

0.69

4.6

3.2

0.0

estimate

0.00

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.54

0.67

19.1

6.4

—

(3037121) Protein [Mass/volume] in Urine

1.82

0.67

4.6

4.0

0.3

0.2

g/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

202

1.37

0.65

2.5

2.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.75

0.64

1.2

1.4

—

(3002256) Pathology report gross observation

122

1.46

0.64

1.2

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

1.70

0.62

1.4

1.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

306

1.30

0.61

4.7

3.0

21.8

51.5

ng/l

1.16

201

(40768443) Skin Pathology biopsy report

1.75

0.58

1.2

1.1

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.70

0.57

6.7

8.6

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

170

1.36

0.57

1.2

1.3

3.4

10.1

u/ml

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

1.61

0.55

1.5

2.1

4.4

2.7

mg/l

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

108

1034

1.48

0.54

21.2

13.0

79.2

75.4

umol/l

0.32

108

1034

(3021601) Nitrite [Presence] in Urine by Test strip

448

1.24

0.51

6.1

4.4

0.0

estimate

0.00

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

864

1.29

0.49

5.2

4.8

38.5

39.1

mmol/mol

0.22

805

(3017143) Hepatitis C virus Ab [Presence] in Serum

130

1.36

0.47

3.2

1.6

—

(3016879) Cocaine [Presence] in Urine

1.45

0.47

3.3

1.4

—

(3044889) 12 lead EKG panel

611

1.22

0.46

3.1

3.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.64

0.43

1.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.41

0.42

1.0

1.1

—

(40761535) Cells panel - Urine sediment

1.45

0.40

7.3

3.4

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.39

0.39

1.3

1.8

361.9

379.3

nmol/l

0.12

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.39

0.0

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.39

0.0

1.1

—

(21494755) Public health laboratory ask at order entry panel

123

0.71

0.37

1.2

1.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.64

0.37

1.8

1.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.49

0.36

1.3

1.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.49

0.36

3.7

1.6

—

(3013512) EKG study

248

1.22

0.36

4.6

3.5

—

(3022313) Gas panel - Capillary blood

1.42

0.35

4.3

2.8

—

(3019060) Gas panel - Arterial blood

1.32

0.33

2.8

4.0

—

(3000764) Benzodiazepines [Presence] in Urine

1.40

0.32

3.4

1.5

—

(3022621) pH of Urine by Test strip

1.37

0.32

2.3

2.5

—

(3027008) Opiates [Presence] in Urine

1.37

0.32

3.3

1.4

—

(3028300) Cannabinoids [Presence] in Urine

1.37

0.32

3.3

1.4

—

(3008898) HLA-B27 [Presence]

1.34

0.31

1.0

1.1

—

(3027944) Amphetamines [Presence] in Urine

1.34

0.31

3.3

1.4

—

(36660697) Celiac disease serology panel - Serum

1.34

0.31

1.2

1.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

159

1.23

0.29

1.3

1.5

—

(3012516) Albumin [Mass/volume] in Urine

218

1.19

0.26

2.4

3.3

40.8

59.9

mg/l

0.45

141

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

144

1.21

0.23

6.4

2.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

259

1.16

0.23

3.7

2.9

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

100

0.79

0.22

1.6

1.8

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.9

—

2.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

4.6

—

22.8

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

2.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

952

1.17

0.21

4.2

4.0

1.4

1.5

mmol/l

1.11

881

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.20

0.0

2.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

137

1.19

0.20

5.9

2.1

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

185

1.16

0.19

2.0

2.8

0.7

ug/l

0.03

116

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

956

1.14

0.17

4.1

4.0

4.6

4.7

mmol/l

0.22

891

(40761536) Microorganisms panel - Urine sediment

1.17

0.16

3.7

2.9

—

(4035726)

1.21

0.14

1.5

1.4

—

(3022145) Colonoscopy Study observation

1.19

0.13

1.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

239

1.11

0.13

3.8

4.3

27.8

22.7

0.37

111

(3020682) Albumin/Creatinine [Ratio] in Urine

230

1.11

0.13

2.9

4.0

7.7

9.1

mg/mmol

0.13

152

(1761868) Lipid panel - Serum or Plasma

358

1.09

0.12

2.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.16

0.10

1.5

1.6

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.08

0.09

1.3

1.1

—

(4010399)

0.77

0.08

1.6

1.4

—

(3026008) Bacteria identified in Urine by Culture

235

0.92

0.08

4.0

2.5

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

177

1.09

0.07

2.0

1.6

422.0

451.4

pmol/l

0.21

156

(40761511) CBC panel - Blood by Automated count

103

1019

1.08

0.05

20.4

10.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

351

0.96

0.04

5.7

3.3

—

(3029937) Albumin [Presence] in Urine by Test strip

239

0.95

0.03

7.8

3.3

0.0

estimate

0.49

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

112

1.08

0.03

2.3

1.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

922

1.04

0.02

3.9

3.6

1.5

1.3

mmol/l

1.02

849

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

973

1.04

0.01

4.3

4.4

2.8

mmol/l

0.25

898

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

931

1.00

0.00

3.8

4.0

5.9

5.8

mmol/l

0.26

857

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

115

1.05

0.00

5.1

4.1

28.8

32.2

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

338.2

—

(3048518) aPTT.lupus sensitive actual/normal (normalized LA screen)

0.00

0.0

1.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(3000012) Reticulocyte production index

0.00

0.0

2.6

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.4

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.8

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3017704) Immunofixation for Urine

0.00

0.0

1.2

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

6.7

—

0.6

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.6

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.0

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.3

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.0

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

68.4

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

2.2

—

1.2

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.6

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.6

—

4.9

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

1.1

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.4

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.3

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.0

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.5

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_SHIGELLOSIS and mortality.

Females

Parameter	HR [95% CI]	p-value
AB1_SHIGELLOSIS	1.403 [0.97, 2.03]	0.074
Birth year	0.997 [0.99, 1.01]	0.426

During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 381 females with AB1_SHIGELLOSIS died.

Males

Parameter	HR [95% CI]	p-value
AB1_SHIGELLOSIS	1.969 [1.19, 3.26]	0.008
Birth year	0.99 [0.98, 1.0]	0.026

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 341 males with AB1_SHIGELLOSIS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_SHIGELLOSIS.

N-year risk	Females	Males
1	0.135%	0.421%
5	0.893%	2.237%
10	2.16%	5.996%
15	4.042%	11.162%
20	6.91%	18.953%

Relationships between endpoints

↥

Index endpoint: AB1_SHIGELLOSIS – Shigellosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Shigellosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints