No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
127 |
4. Check minimum number of eventsNone |
127 |
5. Include endpointsNone |
127 |
6. Filter based on genotype QC (FinnGen only) |
117 |
Control definitions (FinnGen only)
- Control exclude
- AB1_INTESTINAL_INFECTIONS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Shigellosis
based on the number of shared cases.
Similar with more cases:
- Shigellosis
- Intestinal infectious diseases
- Intestinal infectious diseases
- Certain infectious and parasitic diseases
- Certain infectious and parasitic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 973 | 504 | 461 |
| Only index persons | 826 | 445 | 381 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 39.41 | 39.06 | 39.80 |
| Only index persons | 36.35 | 36.63 | 36.02 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 117 | 64 | 53 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 42.89 | 39.78 | 46.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 127
- Matched controls
- 1270
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A03.9
ICD-10 Finland
Shigellosis, unspecified
+∞
48.0
43
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
9.7
31.4
46
70
A03.3
ICD-10 Finland
Shigellosis due to Shigella sonnei
+∞
22.6
21
*
A03.0
ICD-10 Finland
Shigellosis due to Shigella dysenteriae
+∞
20.3
19
*
A03
ICD-10 Finland
Shigellosis
+∞
13.8
13
*
00920
ICD-8 Finland
Diarrhoeal disease, Gastroenteritis (acuta) (infectiosa)
+∞
8.4
8
*
A03.1
ICD-10 Finland
Shigellosis due to Shigella flexneri
+∞
8.4
8
*
J01MA02
ATC
ciprofloxacin; systemic
2.8
7.4
57
286
0049X
ICD-9 Finland
Shigellosis, unspecified
+∞
7.4
7
*
A03.8
ICD-10 Finland
Other shigellosis
+∞
7.4
7
*
A28
ICPC
Limited function/disability NOS
3.8
7.1
24
73
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.6
6.9
26
85
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
19
40
5.41
8.92
2.4
1.4
—
—
—
0
0
17
25
7.67
7.60
2.1
1.1
—
—
—
0
0
17
25
7.67
7.60
2.1
1.1
—
—
—
0
0
20
58
3.91
6.31
2.6
1.4
—
—
—
0
0
10
17
6.28
4.22
1.8
1.3
—
—
—
0
0
62
416
1.96
3.40
6.9
4.9
1.20
1.22
mmol/l
1.66
56
381
11
34
3.44
2.80
2.1
4.1
23.91
23.75
mmol/l
0.06
11
34
63
445
1.82
2.80
9.1
5.5
1.20
1.22
mmol/l
1.12
51
380
10
29
3.65
2.76
1.0
2.6
—
—
—
0
0
9
26
3.64
2.53
2.0
1.6
—
—
—
0
0
15
64
2.52
2.50
6.6
1.8
—
—
—
0
0
26
142
2.04
2.46
2.2
1.9
—
—
—
0
0
49
333
1.77
2.39
2.0
1.8
97.66
98.98
pmol/l
0.07
28
167
5
8
6.45
2.39
1.4
2.0
88.40
86.38
%
—
5
8
12
48
2.66
2.26
7.7
1.7
—
—
—
0
0
77
603
1.70
2.20
13.0
10.0
4.05
3.94
e9/l
0.14
69
531
94
779
1.80
2.18
9.6
6.8
83.13
76.18
u/l
0.91
87
725
5
10
5.15
2.09
1.0
1.2
—
—
—
0
0
115
1024
2.30
2.07
20.6
11.3
26.02
20.47
mg/l
1.04
99
769
7
21
3.46
1.99
1.9
1.4
—
—
—
0
0
110
968
2.02
1.97
17.1
10.8
85.54
85.67
ml/min/173m2
0.02
93
779
6
17
3.65
1.86
2.5
1.1
—
—
—
0
0
37
253
1.65
1.70
3.7
2.7
0.16
0.29
e6/l
0.46
28
179
6
19
3.26
1.68
2.7
1.3
—
—
—
0
0
7
26
2.79
1.60
1.6
1.2
—
—
—
0
0
11
51
2.27
1.55
3.6
4.5
24.75
24.57
mmol/l
0.06
11
51
87
738
1.57
1.53
3.8
3.3
—
—
—
0
0
92
791
1.59
1.52
3.9
3.7
14.38
14.68
pmol/l
0.56
82
721
17
95
1.91
1.52
2.2
1.8
—
—
—
0
0
31
209
1.64
1.49
3.2
3.1
1726.79
891.92
ng/l
0.58
26
181
17
96
1.89
1.47
2.2
1.6
—
—
—
0
0
6
22
2.81
1.45
1.7
1.6
—
—
—
0
0
5
16
3.21
1.45
3.8
2.1
25.64
23.54
mmol/l
—
5
16
5
16
3.21
1.45
1.4
1.4
—
—
—
0
0
63
503
1.50
1.44
9.0
6.2
10.83
11.40
umol/l
0.18
55
475
17
98
1.85
1.39
11.9
5.5
105.00
104.13
mmol/l
0.38
17
98
13
69
1.98
1.34
15.1
2.9
57.75
69.56
ml/min/173m2
—
8
25
34
241
1.56
1.33
1.4
1.2
7.99
1.11
u/ml
—
9
60
88
760
1.51
1.32
4.0
3.6
15.65
9.74
mm/h
1.88
80
698
113
1037
1.81
1.28
22.2
12.2
139.21
139.87
mmol/l
1.99
108
1000
6
25
2.47
1.26
1.2
1.7
—
—
—
0
0
22
142
1.66
1.25
1.7
1.6
1603.03
1219.80
nmol/l
0.47
17
103
30
210
1.56
1.24
2.1
1.5
1.42
1.20
mg/l
0.13
21
165
5
19
2.70
1.22
1.4
1.1
—
—
—
0
0
113
1042
1.77
1.19
22.4
12.3
3.94
3.97
mmol/l
0.63
108
1005
8
39
2.12
1.17
2.4
1.8
—
—
—
0
0
16
97
1.74
1.13
4.9
2.9
—
—
—
0
0
27
189
1.54
1.11
1.2
1.3
9.33
21.89
iu/ml
—
6
66
8
41
2.01
1.11
1.8
1.5
—
—
—
0
0
23
157
1.57
1.05
3.1
2.9
1572.86
116.77
ng/l
0.43
14
110
22
150
1.56
1.01
2.1
2.7
0.44
1.27
e6/l
—
10
80
57
470
1.39
1.00
4.8
3.3
0.00
0.00
estimate
-0.00
13
93
53
432
1.39
1.00
2.5
2.3
—
—
—
0
0
9
50
1.86
0.99
5.9
7.0
0.73
0.74
%
—
9
50
105
963
1.52
0.98
4.5
4.3
1.82
1.88
mu/l
0.17
94
876
9
51
1.82
0.97
5.9
6.9
0.98
1.57
%
—
9
51
41
323
1.40
0.93
4.1
2.9
—
—
—
0
0
6
29
2.12
0.90
1.3
1.2
—
—
—
0
0
50
411
1.36
0.88
22.1
11.8
1.31
1.17
inr
0.51
21
123
8
45
1.83
0.86
3.5
1.4
—
—
—
0
0
8
46
1.79
0.84
1.5
1.8
—
—
—
0
0
6
32
1.92
0.83
1.0
1.3
0.23
0.26
g/l
—
6
32
57
485
1.32
0.78
4.8
3.3
0.00
0.00
estimate
-0.00
12
85
20
144
1.46
0.73
1.6
1.9
1.29
1.40
%
0.40
15
129
5
25
2.04
0.73
1.2
1.4
—
—
—
0
0
5
25
2.04
0.73
1.2
1.4
—
—
—
0
0
5
25
2.04
0.73
1.2
1.4
—
—
—
0
0
7
40
1.79
0.72
2.1
2.4
—
—
—
0
0
122
1177
1.93
0.70
30.1
17.1
39.76
40.72
%
1.50
117
1107
19
137
1.45
0.69
2.1
2.9
2.38
2.74
e6/l
—
8
67
7
42
1.70
0.69
2.4
2.1
—
—
—
0
0
7
43
1.66
0.68
4.6
2.8
23.77
25.17
mmol/l
—
7
43
82
743
1.29
0.66
3.5
2.9
50.45
43.68
u/l
0.26
73
700
39
324
1.29
0.61
5.2
3.0
20.52
49.13
ng/l
1.21
26
214
55
479
1.26
0.59
6.2
4.5
0.00
0.00
estimate
-0.00
12
90
99
926
1.31
0.58
5.3
4.8
38.82
39.10
mmol/mol
0.11
90
861
6
36
1.70
0.57
1.3
1.7
—
—
—
0
0
22
171
1.35
0.54
1.3
1.4
—
—
—
0
0
14
100
1.45
0.54
1.5
1.8
338.36
378.03
nmol/l
0.33
14
89
23
183
1.31
0.49
1.2
1.3
3.41
11.02
u/ml
—
10
80
27
220
1.29
0.49
1.8
1.6
—
—
—
0
0
115
1106
1.42
0.49
21.8
13.1
79.10
75.09
umol/l
0.36
115
1106
30
249
1.27
0.47
2.8
3.8
6.72
8.99
mg/mmol
0.25
14
163
14
104
1.39
0.45
19.1
6.3
—
—
—
0
0
5
33
1.54
0.42
1.6
1.6
—
—
—
0
0
8
111
0.70
0.39
1.6
1.8
—
—
—
0
0
6
46
1.32
0.33
1.5
1.9
4.39
3.07
mg/l
—
6
30
26
225
1.20
0.29
2.5
2.1
—
—
—
0
0
18
151
1.22
0.27
6.1
2.2
—
—
—
0
0
105
1016
1.19
0.26
4.2
4.0
1.41
1.47
mmol/l
0.86
95
941
17
143
1.22
0.25
5.6
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
4.6
—
22.80
—
0
10
105
1022
1.16
0.20
4.0
4.1
4.60
4.68
mmol/l
0.33
96
952
7
60
1.18
0.18
1.3
1.1
—
—
—
0
0
27
245
1.13
0.17
3.7
4.3
27.77
22.73
%
0.37
12
112
21
190
1.13
0.14
2.0
2.8
0.73
0.70
ug/l
0.04
11
118
21
192
1.11
0.11
2.0
1.6
401.56
452.66
pmol/l
0.46
16
164
27
252
1.09
0.10
7.7
3.5
0.00
0.01
estimate
0.49
13
88
105
1039
1.06
0.04
4.4
4.5
2.82
2.79
mmol/l
0.09
96
959
38
373
1.03
0.01
5.9
3.3
—
—
—
0
0
12
126
0.95
0.00
5.1
4.1
28.83
32.44
%
—
6
86
100
994
1.03
0.00
3.8
4.1
5.90
5.82
mmol/l
0.23
93
913
99
984
1.03
0.00
3.9
3.6
1.46
1.26
mmol/l
0.97
86
905
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.1
—
59.86
—
0
7
0
8
0.00
-0.00
0.0
1.6
—
4.88
—
0
8
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_SHIGELLOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_SHIGELLOSIS | 1.403 [0.97, 2.03] | 0.074 |
| Birth year | 0.997 [0.99, 1.01] | 0.426 |
During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 381 females with AB1_SHIGELLOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_SHIGELLOSIS | 1.969 [1.19, 3.26] | 0.008 |
| Birth year | 0.99 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 341 males with AB1_SHIGELLOSIS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_SHIGELLOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.135% | 0.421% |
| 5 | 0.893% | 2.237% |
| 10 | 2.16% | 5.996% |
| 15 | 4.042% | 11.162% |
| 20 | 6.91% | 18.953% |
Relationships between endpoints
↥Index endpoint: AB1_SHIGELLOSIS – Shigellosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data