No definition available.
Brain astrocytoma, excluding all cancers (controls excluding all cancers)
C3_ASTROCYTOMA_EXALLC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
143 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
143 |
4. Check minimum number of eventsNone |
143 |
5. Include endpoints |
143 |
6. Filter based on genotype QC (FinnGen only) |
143 |
Control definitions (FinnGen only)
- Control exclude
- C3_CANCER, C3_CANCER_WIDE_EXALLC
- Control conditions
- not HLP_C3_ASTROCYTOMA
Extra metadata
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Brain astrocytoma, excluding all cancers (controls excluding all cancers)
based on the number of shared cases.
Similar with more cases:
- Brain astrocytoma
- Brain glioblastoma and astrocytoma, excluding all cancers (controls excluding all cancers)
- Brain glioblastoma and astrocytoma
- Malignant neoplasm of brain
- Malignant neoplasm of eye, brain and central nervous system
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 143 | 71 | 72 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 40.81 | 38.49 | 43.09 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 135
- Matched controls
- 1350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
128.5
102
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
+∞
125.3
100
*
L01AX03
ATC
temozolomide; systemic
+∞
112.9
92
*
H02AB02
ATC
dexamethasone; systemic
604.3
108.1
94
5
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
163.9
105.9
106
29
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
65.8
79.6
94
45
C71.11
ICD-10 Finland
Malignant tumor of frontal lobe grade II glioma
+∞
77.8
67
*
N03AX14
ATC
levetiracetam; systemic
128.9
76.8
78
14
A04AA02
ATC
granisetron; systemic, transdermal
+∞
75.2
65
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
168.4
73.2
72
9
C71.10
ICD-10 Finland
Malignant tumor in frontal lobe without histology
+∞
58.7
52
*
9400/3-C71.9
ICD-O-3
Astrocytoma, NOS, of brain, NOS
+∞
53.8
48
*
WF002
NOMESCO Finland
Radical radiotherapy
+∞
53.8
48
*
A03FA01
ATC
metoclopramide; systemic, rectal
28.9
53.1
77
59
9400/3-C71.1
ICD-O-3
Astrocytoma, NOS, of frontal lobe
+∞
51.4
46
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
107.5
50.7
53
8
ZXC95
NOMESCO Finland
Use of surgical navigator
680.2
49.7
46
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
49.0
44
*
C71.21
ICD-10 Finland
Malignant tumor of temporal lobe grade II glioma
+∞
49.0
44
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
87.0
46.4
50
9
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
322.6
46.0
44
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
118.5
45.4
47
6
N03AF02
ATC
oxcarbazepine; oral
45.8
41.2
50
17
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
36.1
33
*
XX3DW
NOMESCO Finland
Time consuming IT work
32.5
34.8
46
21
R56.8
ICD-10 Finland
Other and unspecified convulsions
22.7
34.2
51
35
C71.20
ICD-10 Finland
Malignant tumor in temporal lobe without histology
+∞
32.6
30
*
AA1AD
NOMESCO Finland
CT of head and brain
10.3
31.4
76
150
XA800
NOMESCO Finland
Neuropsychological investigation
25.5
31.1
44
25
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
+∞
30.4
28
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
29.2
27
*
A04AA01
ATC
ondansetron; systemic, rectal
35.8
27.5
35
13
ZXC40
NOMESCO Finland
Use of ultrasound
319.0
26.7
26
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
29.5
24.0
32
14
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
9.4
23.7
55
92
N03AB02
ATC
phenytoin; systemic
274.7
23.4
23
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
10.7
23.0
48
66
9400/3-C71.2
ICD-O-3
Astrocytoma, NOS, of temporal lobe
+∞
22.5
21
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
260.5
22.3
22
*
Z51.5
ICD-10 Finland
Palliative care
260.5
22.3
22
*
N03AX18
ATC
lacosamide; systemic
91.3
21.4
23
*
AAG00
NOMESCO Finland
Stereotactic intracranial biopsy
+∞
21.4
20
*
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
130.3
21.3
22
*
C71.12
ICD-10 Finland
Malignant tumor of frontal lobe grade III glioma
+∞
20.3
19
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.9
19.9
75
237
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
19.2
18
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
58.2
17.5
20
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
32.4
17.1
22
8
C71.1
ICD-10 Finland
Malignant neoplasm: Frontal lobe
+∞
17.0
16
*
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
38.7
16.3
20
6
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
+∞
15.9
15
*
C71.22
ICD-10 Finland
Malignant tumor of temporal lobe grade III glioma
+∞
15.9
15
*
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
+∞
15.9
15
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
43.8
15.9
19
5
WX882
NOMESCO Finland
High dependency care
19.9
14.9
22
13
C71.29
ICD-10 Finland
Malignant tumor in temporal lobe other or unspecified histology
+∞
14.9
14
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
14.9
14
*
N03AG01
ATC
valproic acid; systemic, rectal
9.0
14.3
31
43
A02BC02
ATC
pantoprazole; systemic
4.4
14.3
100
528
N05BA09
ATC
clobazam; oral
83.5
13.9
15
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
+∞
13.8
13
*
C71.31
ICD-10 Finland
Malignant tumor of the parietal lobe grand II glioma
+∞
13.8
13
*
R4150
NOMESCO Finland
Neuropsychological rehabilitation
35.9
12.9
16
5
183
Kela drug reimbursment
Lamotrigin and topiramate
77.4
12.8
14
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
77.4
12.8
14
*
C71.2
ICD-10 Finland
Malignant neoplasm: Temporal lobe
+∞
12.7
12
*
H53.4
ICD-10 Finland
Visual field defects
41.8
12.5
15
*
N03AF01
ATC
carbamazepine; oral, rectal
11.7
12.0
22
22
WF029
NOMESCO Finland
Radiotherapy of local residive tumor
+∞
11.6
11
*
C71.01
ICD-10 Finland
Malignant tumor of cerebellum except lobes and ventricles grade II glioma
+∞
11.6
11
*
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
+∞
11.6
11
*
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
130.7
11.6
12
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.4
11.6
48
150
WZC30
NOMESCO Finland
Teaching
6.7
11.1
29
53
G40.10
ICD-10 Finland
Simple partial seizures
118.9
10.6
11
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
10.5
10
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
10.5
10
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
10.5
10
*
C71.19
ICD-10 Finland
Malignant tumor of frontal lobe other or unspecified histology
+∞
10.5
10
*
AAA10
NOMESCO Finland
Biopsy through craniotomy
+∞
10.5
10
*
C71.81
ICD-10 Finland
Overall malignant tumor of the brain grade II glioma
+∞
10.5
10
*
C71.30
ICD-10 Finland
Malignant tumor in parietal lobe without histology
+∞
10.5
10
*
AA1BD
NOMESCO Finland
Extensive CT of head and brain
25.8
10.5
14
6
ZXE20
NOMESCO Finland
More than three and less than five hours
5.1
9.8
32
77
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
32.6
9.6
12
*
C71.99
ICD-10 Finland
Malignant tumor in unspecified localization in the brain other or unspecified histology
+∞
9.5
9
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
9.5
9
*
WX872
NOMESCO Finland
Intensive care
9.7
9.1
18
21
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
26.1
9.1
12
5
WX402
NOMESCO Finland
General anaesthesia
4.4
8.9
34
96
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.7
8.5
41
142
9400/3-C71.0
ICD-O-3
Astrocytoma, NOS, of cerebrum
+∞
8.4
8
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
9.2
7.5
15
18
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
84.5
7.5
8
*
D43.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, unspecified
+∞
7.4
7
*
ZXM40
NOMESCO Finland
Use of fluorescent substance
+∞
7.4
7
*
C71.00
ICD-10 Finland
Malignant tumor of the cerebrum except lobes and ventricles without histology
+∞
7.4
7
*
N03AX23
ATC
brivaracetam; systemic
+∞
7.4
7
*
C71.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of brain
+∞
7.4
7
*
9400/3-C71.3
ICD-O-3
Astrocytoma, NOS, of parietal lobe
+∞
7.4
7
*
G40
ICD-10 Finland
Epilepsy
31.9
7.2
9
*
H02AB09
ATC
hydrocortisone; systemic
14.8
7.0
11
8
R4130
NOMESCO Finland
Speech therapy
17.8
6.9
10
6
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
23.9
6.8
9
*
JN4CD
NOMESCO Finland
Very extensive body CT
73.2
6.5
7
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.8
6.3
27
84
C71.23
ICD-10 Finland
Malignant tumor of temporal lobe grade IV glioma
+∞
6.3
6
*
C71.13
ICD-10 Finland
Malignant tumor of frontal lobe grade IV glioma
+∞
6.3
6
*
WC105
NOMESCO Finland
Simple cytostatic therapy of local tumor recidive
+∞
6.3
6
*
C71.40
ICD-10 Finland
Malignant tumor of the occipital lobe without histology
+∞
6.3
6
*
N76
ICPC
Neoplasm nervous system unspecified
+∞
6.3
6
*
AA5NK
NOMESCO Finland
Tractography within white matter of central nervous system
+∞
6.3
6
*
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: C3_ASTROCYTOMA_EXALLC – Brain astrocytoma, excluding all cancers (controls excluding all cancers)
GWS hits: 2
This endpoint is excluded (different definition than used in FinnGen).