Brain astrocytoma, excluding all cancers (controls excluding all cancers)

C3_ASTROCYTOMA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • HLP_C3_ASTROCYTOMA
143

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C71
  • Hospital discharge: ICD-9 191
  • Hospital discharge: ICD-8 191
  • Cause of death: ICD-10 C71
  • Cause of death: ICD-9 191
  • Cause of death: ICD-8 191
  • Cancer registry: Topography ICD-O-3 C71
  • Cancer registry: Morphology ICD-O-3 9400
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

143

4. Check minimum number of events

None

143

5. Include endpoints

143

6. Filter based on genotype QC (FinnGen only)

143

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC
Control conditions
not HLP_C3_ASTROCYTOMA

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 143 71 72
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 40.81 38.49 43.09

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
135
Matched controls
1350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
128.5
102
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
+∞
125.3
100
*
L01AX03
ATC
temozolomide; systemic
+∞
112.9
92
*
H02AB02
ATC
dexamethasone; systemic
604.3
108.1
94
5
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
163.9
105.9
106
29
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
65.8
79.6
94
45
C71.11
ICD-10 Finland
Malignant tumor of frontal lobe grade II glioma
+∞
77.8
67
*
N03AX14
ATC
levetiracetam; systemic
128.9
76.8
78
14
A04AA02
ATC
granisetron; systemic, transdermal
+∞
75.2
65
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
168.4
73.2
72
9
C71.10
ICD-10 Finland
Malignant tumor in frontal lobe without histology
+∞
58.7
52
*
WF002
NOMESCO Finland
Radical radiotherapy
+∞
53.8
48
*
9400/3-C71.9
ICD-O-3
Astrocytoma, NOS, of brain, NOS
+∞
53.8
48
*
A03FA01
ATC
metoclopramide; systemic, rectal
28.9
53.1
77
59
9400/3-C71.1
ICD-O-3
Astrocytoma, NOS, of frontal lobe
+∞
51.4
46
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
107.5
50.7
53
8
ZXC95
NOMESCO Finland
Use of surgical navigator
680.2
49.7
46
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
49.0
44
*
C71.21
ICD-10 Finland
Malignant tumor of temporal lobe grade II glioma
+∞
49.0
44
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
87.0
46.4
50
9
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
322.6
46.0
44
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
118.5
45.4
47
6
N03AF02
ATC
oxcarbazepine; oral
45.8
41.2
50
17
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
36.1
33
*
XX3DW
NOMESCO Finland
Time consuming IT work
32.5
34.8
46
21
R56.8
ICD-10 Finland
Other and unspecified convulsions
22.7
34.2
51
35
C71.20
ICD-10 Finland
Malignant tumor in temporal lobe without histology
+∞
32.6
30
*
AA1AD
NOMESCO Finland
CT of head and brain
10.3
31.4
76
150
XA800
NOMESCO Finland
Neuropsychological investigation
25.5
31.1
44
25
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
+∞
30.4
28
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
29.2
27
*
A04AA01
ATC
ondansetron; systemic, rectal
35.8
27.5
35
13
ZXC40
NOMESCO Finland
Use of ultrasound
319.0
26.7
26
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
29.5
24.0
32
14
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
9.4
23.7
55
92
N03AB02
ATC
phenytoin; systemic
274.7
23.4
23
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
10.7
23.0
48
66
9400/3-C71.2
ICD-O-3
Astrocytoma, NOS, of temporal lobe
+∞
22.5
21
*
Z51.5
ICD-10 Finland
Palliative care
260.5
22.3
22
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
260.5
22.3
22
*
N03AX18
ATC
lacosamide; systemic
91.3
21.4
23
*
AAG00
NOMESCO Finland
Stereotactic intracranial biopsy
+∞
21.4
20
*
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
130.3
21.3
22
*
C71.12
ICD-10 Finland
Malignant tumor of frontal lobe grade III glioma
+∞
20.3
19
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.9
19.9
75
237
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
19.2
18
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
58.2
17.5
20
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
32.4
17.1
22
8
C71.1
ICD-10 Finland
Malignant neoplasm: Frontal lobe
+∞
17.0
16
*
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
38.7
16.3
20
6
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
+∞
15.9
15
*
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
+∞
15.9
15
*
C71.22
ICD-10 Finland
Malignant tumor of temporal lobe grade III glioma
+∞
15.9
15
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
43.8
15.9
19
5
WX882
NOMESCO Finland
High dependency care
19.9
14.9
22
13
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
14.9
14
*
C71.29
ICD-10 Finland
Malignant tumor in temporal lobe other or unspecified histology
+∞
14.9
14
*
N03AG01
ATC
valproic acid; systemic, rectal
9.0
14.3
31
43
A02BC02
ATC
pantoprazole; systemic
4.4
14.3
100
528
N05BA09
ATC
clobazam; oral
83.5
13.9
15
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
+∞
13.8
13
*
C71.31
ICD-10 Finland
Malignant tumor of the parietal lobe grand II glioma
+∞
13.8
13
*
R4150
NOMESCO Finland
Neuropsychological rehabilitation
35.9
12.9
16
5
183
Kela drug reimbursment
Lamotrigin and topiramate
77.4
12.8
14
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
77.4
12.8
14
*
C71.2
ICD-10 Finland
Malignant neoplasm: Temporal lobe
+∞
12.7
12
*
H53.4
ICD-10 Finland
Visual field defects
41.8
12.5
15
*
N03AF01
ATC
carbamazepine; oral, rectal
11.7
12.0
22
22
WF029
NOMESCO Finland
Radiotherapy of local residive tumor
+∞
11.6
11
*
C71.01
ICD-10 Finland
Malignant tumor of cerebellum except lobes and ventricles grade II glioma
+∞
11.6
11
*
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
+∞
11.6
11
*
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
130.7
11.6
12
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.4
11.6
48
150
WZC30
NOMESCO Finland
Teaching
6.7
11.1
29
53
G40.10
ICD-10 Finland
Simple partial seizures
118.9
10.6
11
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
10.5
10
*
C71.81
ICD-10 Finland
Overall malignant tumor of the brain grade II glioma
+∞
10.5
10
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
10.5
10
*
AAA10
NOMESCO Finland
Biopsy through craniotomy
+∞
10.5
10
*
C71.30
ICD-10 Finland
Malignant tumor in parietal lobe without histology
+∞
10.5
10
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
10.5
10
*
C71.19
ICD-10 Finland
Malignant tumor of frontal lobe other or unspecified histology
+∞
10.5
10
*
AA1BD
NOMESCO Finland
Extensive CT of head and brain
25.8
10.5
14
6
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
32.6
9.6
12
*
C71.99
ICD-10 Finland
Malignant tumor in unspecified localization in the brain other or unspecified histology
+∞
9.5
9
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
9.5
9
*
WX872
NOMESCO Finland
Intensive care
9.7
9.1
18
21
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
26.1
9.1
12
5
WX402
NOMESCO Finland
General anaesthesia
4.4
8.9
34
96
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.7
8.5
41
142
9400/3-C71.0
ICD-O-3
Astrocytoma, NOS, of cerebrum
+∞
8.4
8
*
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
84.5
7.5
8
*
C71.00
ICD-10 Finland
Malignant tumor of the cerebrum except lobes and ventricles without histology
+∞
7.4
7
*
9400/3-C71.3
ICD-O-3
Astrocytoma, NOS, of parietal lobe
+∞
7.4
7
*
ZXM40
NOMESCO Finland
Use of fluorescent substance
+∞
7.4
7
*
C71.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of brain
+∞
7.4
7
*
D43.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, unspecified
+∞
7.4
7
*
N03AX23
ATC
brivaracetam; systemic
+∞
7.4
7
*
G40
ICD-10 Finland
Epilepsy
31.9
7.2
9
*
H02AB09
ATC
hydrocortisone; systemic
14.8
7.0
11
8
R4130
NOMESCO Finland
Speech therapy
17.8
6.9
10
6
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
23.9
6.8
9
*
JN4CD
NOMESCO Finland
Very extensive body CT
73.2
6.5
7
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.8
6.3
27
84
N76
ICPC
Neoplasm nervous system unspecified
+∞
6.3
6
*
C71.13
ICD-10 Finland
Malignant tumor of frontal lobe grade IV glioma
+∞
6.3
6
*
AA5NK
NOMESCO Finland
Tractography within white matter of central nervous system
+∞
6.3
6
*
C71.23
ICD-10 Finland
Malignant tumor of temporal lobe grade IV glioma
+∞
6.3
6
*
C71.40
ICD-10 Finland
Malignant tumor of the occipital lobe without histology
+∞
6.3
6
*
WC105
NOMESCO Finland
Simple cytostatic therapy of local tumor recidive
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
82
31
60.67
128.58
1.4
1.3
—
—
—
0
0
70
87
14.80
58.01
5.5
15.3
0.8
1.7
mmol/l
1.23
51
68
50
43
17.34
51.87
4.0
7.6
23.8
25.4
mmol/l
1.64
50
43
107
442
6.64
24.66
6.7
6.6
1.2
1.2
mmol/l
1.06
95
387
22
16
16.07
24.19
2.0
1.4
—
—
—
0
0
84
308
5.19
21.54
2.2
1.9
—
—
—
0
0
91
359
5.22
21.20
3.3
1.6
—
—
—
0
0
18
15
13.58
18.15
1.8
1.3
—
—
—
0
0
29
48
7.32
17.63
5.9
13.9
96.4
93.9
%
3.28
29
48
100
477
4.65
16.95
3.3
4.1
—
—
—
0
0
78
321
4.15
16.02
4.0
6.9
1.0
1.2
inr
1.62
20
85
22
30
8.48
15.72
1.9
1.2
—
—
—
0
0
111
642
4.26
12.81
16.6
7.2
3.4
4.2
e9/l
4.61
100
564
23
42
6.33
12.58
7.7
23.7
—
—
—
0
0
66
282
3.49
12.08
7.5
2.1
2.4
2.4
mmol/l
0.67
59
240
76
358
3.40
11.82
8.6
6.2
—
—
—
0
0
20
35
6.48
11.36
1.7
1.1
34.3
2.2
e6/l
1.23
14
26
20
35
6.48
11.36
1.8
1.3
1025.9
32.6
e6/l
0.48
15
28
22
51
4.92
9.24
5.4
14.7
—
—
—
0
0
96
578
3.01
8.88
9.1
6.5
0.1
0.2
e9/l
11.97
85
521
94
562
2.96
8.77
9.1
6.1
0.5
0.5
e9/l
0.43
83
499
94
563
2.95
8.72
9.2
6.1
0.0
0.0
e9/l
4.75
82
502
90
532
2.87
8.47
9.4
6.6
9.3
8.4
%
1.91
90
509
88
516
2.83
8.38
9.3
6.4
0.5
0.7
%
4.17
88
487
89
527
2.82
8.28
9.2
6.2
2.1
3.0
%
4.61
89
502
90
542
2.78
8.01
9.3
6.1
60.0
57.0
%
1.29
90
518
90
550
2.72
7.65
9.5
6.3
26.3
29.2
%
1.43
90
525
93
582
2.71
7.46
9.3
6.2
1.4
1.9
e9/l
9.17
83
523
64
344
2.56
6.90
1.3
1.5
—
—
—
0
0
23
69
3.78
6.90
8.0
9.9
—
—
—
0
0
47
218
2.72
6.82
3.4
4.1
—
—
—
0
0
10
15
7.09
6.40
1.9
1.2
—
—
—
0
0
91
1159
0.41
5.81
2.8
3.8
4.8
4.7
mmol/l
0.48
81
1095
50
257
2.45
5.75
10.0
5.8
—
—
—
0
0
91
1154
0.42
5.54
2.8
3.7
1.4
1.4
mmol/l
0.51
81
1088
93
1169
0.42
5.53
2.9
4.1
3.0
2.9
mmol/l
0.75
81
1096
74
462
2.25
5.34
12.8
7.7
0.0
0.0
e9/l
0.48
62
372
49
265
2.29
4.92
2.6
2.7
7.4
7.4
ph
—
9
31
44
229
2.33
4.82
3.2
3.2
—
—
—
0
0
89
1113
0.47
4.36
2.8
3.4
1.3
1.3
mmol/l
0.17
80
1038
58
356
2.06
4.12
2.7
3.0
13.8
36.0
ng/l
1.62
38
189
20
78
2.82
3.92
3.3
4.0
—
—
—
0
0
6
5
12.44
3.79
3.0
6.8
—
—
—
0
0
6
5
12.44
3.79
1.5
3.4
—
—
—
0
0
17
69
2.66
3.09
3.8
4.6
1.8
0.6
%
—
9
16
0
76
0.00
2.84
0.0
1.2
—
506.1
—
0
70
99
1155
0.54
2.81
27.0
11.6
38.7
41.4
%
1.71
76
957
11
263
0.37
2.71
2.5
4.1
1.9
10.0
mg/mmol
—
5
179
10
33
3.18
2.58
3.0
6.0
—
—
—
0
0
7
16
4.54
2.50
3.1
2.1
8.8
8.4
kpa
—
7
16
7
16
4.54
2.50
3.1
2.1
5.2
4.8
kpa
—
7
16
7
16
4.54
2.50
3.1
2.1
2.3
1.9
mmol/l
—
7
10
85
1024
0.58
2.49
3.2
4.7
35.9
38.7
mmol/mol
4.33
74
979
12
48
2.64
2.25
3.5
2.8
1.2
1.2
mmol/l
0.30
12
41
5
9
5.71
2.23
1.4
1.1
93.0
91.8
%
—
5
9
93
1085
0.59
2.22
3.6
3.7
5.5
5.8
mmol/l
2.73
84
1007
6
16
3.86
1.95
2.8
2.1
—
—
—
0
0
14
65
2.28
1.95
3.4
4.7
0.1
0.1
%
—
7
13
0
52
0.00
1.92
0.0
1.1
—
—
—
0
0
36
239
1.68
1.81
2.2
2.6
—
—
—
0
0
30
435
0.61
1.63
3.2
2.7
—
—
—
0
0
127
1155
1.89
1.61
22.6
11.2
139.1
139.7
mmol/l
1.15
127
1124
10
201
0.46
1.59
1.3
1.4
—
—
—
0
0
10
199
0.47
1.55
1.8
1.4
—
—
—
0
0
127
1158
1.86
1.55
21.8
11.3
3.9
3.9
mmol/l
1.56
127
1125
98
1101
0.65
1.52
30.8
13.3
336.4
334.4
g/l
1.12
98
1096
128
1349
0.51
1.46
34.3
14.9
6.5
6.6
e9/l
0.18
128
1317
128
1348
0.52
1.42
34.2
14.8
30.5
30.2
pg
1.41
128
1330
128
1348
0.52
1.42
34.3
14.9
90.7
90.1
fl
0.79
128
1330
128
1348
0.52
1.42
35.3
15.0
135.9
139.7
g/l
2.47
128
1329
81
675
1.46
1.41
3.2
3.7
—
49.4
—
0
9
34
462
0.65
1.34
1.9
2.3
—
—
—
0
0
128
1346
0.53
1.33
34.3
14.9
246.4
252.6
e9/l
0.29
128
1317
0
33
0.00
1.18
0.0
1.6
—
—
—
0
0
0
36
0.00
1.15
0.0
1.1
—
—
—
0
0
13
209
0.58
1.03
1.3
1.7
—
—
—
0
0
86
751
1.36
1.01
3.1
3.8
—
—
—
0
0
11
62
1.84
0.97
1.4
2.6
0.3
0.2
g/l
0.80
11
56
7
129
0.52
0.93
1.1
1.3
—
—
—
0
0
7
130
0.51
0.93
1.0
1.2
—
—
—
0
0
8
140
0.55
0.88
2.4
2.1
—
—
—
0
0
28
366
0.71
0.86
1.9
2.0
—
—
—
0
0
19
131
1.52
0.83
1.2
1.6
—
—
—
0
0
79
694
1.31
0.83
2.9
3.1
—
—
—
0
0
8
47
1.74
0.82
1.4
3.0
—
7.4
—
0
5
26
193
1.42
0.81
2.0
3.3
1867.0
712.0
ng/l
—
10
128
125
1178
1.49
0.80
20.1
10.2
19.6
20.8
mg/l
0.21
116
889
34
266
1.36
0.78
7.4
4.2
—
—
—
0
0
11
168
0.63
0.73
2.3
2.4
0.8
0.8
ug/l
—
5
97
45
533
0.77
0.70
2.8
2.9
0.0
0.0
estimate
—
8
91
7
112
0.61
0.61
1.1
1.3
—
—
—
0
0
10
64
1.60
0.60
2.0
2.5
—
—
—
0
0
0
22
0.00
0.60
0.0
1.1
—
—
—
0
0
0
22
0.00
0.60
0.0
1.3
—
—
—
0
0
99
1058
0.79
0.59
3.9
4.3
1.7
1.7
mu/l
0.38
92
987
5
86
0.57
0.58
2.4
1.5
—
—
—
0
0
5
86
0.57
0.58
2.6
1.5
—
—
—
0
0
46
531
0.80
0.56
4.3
4.2
0.0
0.0
estimate
—
8
89
6
38
1.60
0.55
2.3
1.9
20.5
20.7
s
—
6
33
47
539
0.81
0.53
2.9
3.0
0.0
0.0
estimate
—
8
87
9
64
1.43
0.52
1.7
1.3
18.6
23.0
iu/l
—
9
59
14
102
1.41
0.49
2.3
2.4
—
22.1
—
0
5
23
283
0.78
0.47
1.4
1.7
—
—
—
0
0
22
272
0.77
0.47
1.0
1.3
1.7
2.4
g/l
—
10
158
5
85
0.57
0.47
2.6
1.5
—
—
—
0
0
7
51
1.39
0.44
1.7
1.5
10.2
6.8
u/l
—
7
42
5
32
1.58
0.42
1.6
3.4
—
—
—
0
0
5
33
1.53
0.42
1.4
1.1
—
—
—
0
0
5
33
1.53
0.42
1.4
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
3.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
2.1
—
—
—
0
0
20
244
0.79
0.39
2.6
2.9
—
—
—
0
0
32
274
1.22
0.38
2.5
2.4
0.1
0.2
e6/l
0.51
24
201
32
274
1.22
0.38
2.0
2.3
—
—
—
0
0
17
137
1.27
0.34
1.9
1.6
1369.3
1093.5
nmol/l
—
9
107
10
76
1.34
0.29
2.0
2.6
—
—
—
0
0
9
120
0.73
0.28
1.3
1.4
—
—
—
0
0
98
1020
0.88
0.26
28.7
12.2
13.4
13.4
%
0.02
98
1002
5
74
0.66
0.26
1.0
1.2
—
—
—
0
0
48
520
0.88
0.25
2.0
2.7
91.0
86.6
ug/l
0.09
42
496
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
4.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
153.5
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
9.6
—
0.6
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
28
311
0.88
0.21
2.8
2.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
2.8
—
—
—
0
0
24
269
0.87
0.20
2.9
3.3
0.0
0.0
estimate
—
8
89
34
310
1.13
0.20
2.5
2.3
26.2
270.9
e6/l
0.61
26
236
11
131
0.83
0.18
1.1
2.3
—
—
—
0
0
6
77
0.77
0.16
2.0
2.4
10.1
9.6
ug/l
—
6
68
14
121
1.17
0.15
1.0
1.2
—
—
—
0
0
8
98
0.81
0.14
1.0
1.3
—
145.0
iu/ml
—
0
36
9
105
0.85
0.13
1.6
1.4
—
—
—
0
0
18
198
0.90
0.11
1.4
1.6
—
—
—
0
0
5
43
1.17
0.10
5.6
2.7
—
—
—
0
0
6
57
1.05
0.08
1.2
1.1
—
—
—
0
0
83
848
0.95
0.08
3.6
3.8
14.3
14.5
pmol/l
0.31
77
794
9
101
0.88
0.06
1.3
1.1
—
—
—
0
0
10
90
1.12
0.05
1.7
3.5
—
—
—
0
0
23
242
0.94
0.05
1.3
1.7
0.7
1.0
mg/l
0.69
13
180
36
371
0.96
0.04
1.7
1.8
99.2
98.1
pmol/l
0.05
19
190
126
1261
0.99
0.00
20.6
9.1
—
—
—
0
0
12
123
0.97
0.00
1.3
1.8
—
—
—
0
0
127
1273
0.98
0.00
18.1
7.9
28.1
28.3
u/l
0.04
127
1240
37
372
0.99
0.00
2.8
2.8
49.5
75.2
e6/l
0.22
27
250
8
82
0.97
0.00
2.4
3.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
13.7
—
0
9
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
142.0
—
0
7
0
7
0.00
0.00
0.0
4.7
—
8.1
—
0
7
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
4.2
—
3.6
—
0
6
0
8
0.00
0.00
0.0
1.0
—
293.3
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_ASTROCYTOMA_EXALLC – Brain astrocytoma, excluding all cancers (controls excluding all cancers)

GWS hits: 2

This endpoint is excluded (different definition than used in FinnGen).