This is a non-core endpoint: only basic statistics are computed.
See its core counterpart C3_ASTROCYTOMA_EXALLC for full statistics.
Brain astrocytoma
C3_ASTROCYTOMA
astrocytoma: A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
143 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
143 |
4. Check minimum number of eventsNone |
143 |
5. Include endpoints |
143 |
6. Filter based on genotype QC (FinnGen only) |
143 |
Control definitions (FinnGen only)
- Control conditions
- not HLP_C3_ASTROCYTOMA
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF8
Similar endpoints
↥List of similar endpoints to
Brain astrocytoma
based on the number of shared cases.
Similar with more cases:
- Brain astrocytoma, excluding all cancers (controls excluding all cancers)
- Brain glioblastoma and astrocytoma, excluding all cancers (controls excluding all cancers)
- Brain glioblastoma and astrocytoma
- Malignant neoplasm of brain
- Malignant neoplasm of eye, brain and central nervous system
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 143 | 71 | 72 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 40.83 | 38.49 | 43.14 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 135
- Matched controls
- 1349
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
3628.2
123.3
100
*
L01AX03
ATC
temozolomide; systemic
+∞
112.9
92
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
199.2
109.3
106
24
130
Kela drug reimbursment
Malignant tumour
114.6
96.1
102
35
N03AX14
ATC
levetiracetam; systemic
226.5
82.1
78
8
C71.11
ICD-10 Finland
Malignant tumor of frontal lobe grade II glioma
+∞
77.8
67
*
H02AB02
ATC
dexamethasone; systemic
60.3
77.8
94
49
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
252.6
76.2
72
6
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
51.6
74.4
94
57
C71.10
ICD-10 Finland
Malignant tumor in frontal lobe without histology
824.3
57.0
52
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
215.2
54.4
53
*
9400/3-C71.9
ICD-O-3
Astrocytoma, NOS, of brain, NOS
+∞
53.8
48
*
A04AA02
ATC
granisetron; systemic, transdermal
42.0
51.7
65
29
9400/3-C71.1
ICD-O-3
Astrocytoma, NOS, of frontal lobe
+∞
51.4
46
*
C71.21
ICD-10 Finland
Malignant tumor of temporal lobe grade II glioma
+∞
49.0
44
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
177.9
47.3
47
*
N03AF02
ATC
oxcarbazepine; oral
97.9
47.2
50
8
ZXC95
NOMESCO Finland
Use of surgical navigator
172.2
46.1
46
*
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
322.6
46.0
44
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
71.0
44.9
50
11
WF002
NOMESCO Finland
Radical radiotherapy
36.4
37.4
48
20
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
49.3
37.0
44
13
AA1AD
NOMESCO Finland
CT of head and brain
12.8
36.0
76
123
A03FA01
ATC
metoclopramide; systemic, rectal
12.0
34.9
77
134
XA800
NOMESCO Finland
Neuropsychological investigation
33.7
33.7
44
19
R56.8
ICD-10 Finland
Other and unspecified convulsions
21.4
33.5
51
37
C71.20
ICD-10 Finland
Malignant tumor in temporal lobe without histology
+∞
32.6
30
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
72.0
29.7
33
6
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
29.2
27
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
15.9
28.1
48
45
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
116.8
26.8
28
*
N03AX18
ATC
lacosamide; systemic
+∞
24.7
23
*
XX3DW
NOMESCO Finland
Time consuming IT work
12.6
24.2
46
53
ZXC40
NOMESCO Finland
Use of ultrasound
79.7
23.8
26
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
27.5
23.5
32
15
N03AB02
ATC
phenytoin; systemic
274.7
23.4
23
*
9400/3-C71.2
ICD-O-3
Astrocytoma, NOS, of temporal lobe
+∞
22.5
21
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
8.6
22.4
55
100
AAG00
NOMESCO Finland
Stereotactic intracranial biopsy
+∞
21.4
20
*
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
130.3
21.3
22
*
C71.12
ICD-10 Finland
Malignant tumor of frontal lobe grade III glioma
+∞
20.3
19
*
A04AA01
ATC
ondansetron; systemic, rectal
13.1
19.4
35
35
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
52.1
18.9
22
5
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
77.5
18.3
20
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
109.7
18.1
19
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.2
17.8
75
260
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
58.2
17.5
20
*
WX882
NOMESCO Finland
High dependency care
32.4
17.1
22
8
C71.22
ICD-10 Finland
Malignant tumor of temporal lobe grade III glioma
+∞
15.9
15
*
C71.1
ICD-10 Finland
Malignant neoplasm: Frontal lobe
180.0
15.8
16
*
R4150
NOMESCO Finland
Neuropsychological rehabilitation
90.2
14.9
16
*
C71.29
ICD-10 Finland
Malignant tumor in temporal lobe other or unspecified histology
+∞
14.9
14
*
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
167.4
14.8
15
*
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
167.4
14.8
15
*
N05BA09
ATC
clobazam; oral
83.5
13.9
15
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
+∞
13.8
13
*
C71.31
ICD-10 Finland
Malignant tumor of the parietal lobe grand II glioma
+∞
13.8
13
*
N03AG01
ATC
valproic acid; systemic, rectal
8.2
13.5
31
47
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
14.3
13.2
22
18
Z51.5
ICD-10 Finland
Palliative care
14.3
13.2
22
18
C71.2
ICD-10 Finland
Malignant neoplasm: Temporal lobe
+∞
12.7
12
*
A02BC02
ATC
pantoprazole; systemic
4.0
12.5
100
559
H53.4
ICD-10 Finland
Visual field defects
41.8
12.5
15
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
51.6
12.1
14
*
N03AF01
ATC
carbamazepine; oral, rectal
11.2
11.8
22
23
WF029
NOMESCO Finland
Radiotherapy of local residive tumor
+∞
11.6
11
*
C71.01
ICD-10 Finland
Malignant tumor of cerebellum except lobes and ventricles grade II glioma
+∞
11.6
11
*
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
+∞
11.6
11
*
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
65.3
10.8
12
*
AAA10
NOMESCO Finland
Biopsy through craniotomy
+∞
10.5
10
*
C71.81
ICD-10 Finland
Overall malignant tumor of the brain grade II glioma
+∞
10.5
10
*
C71.30
ICD-10 Finland
Malignant tumor in parietal lobe without histology
+∞
10.5
10
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
25.8
10.5
14
6
ZXE20
NOMESCO Finland
More than three and less than five hours
5.4
10.3
32
73
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
43.6
10.1
12
*
183
Kela drug reimbursment
Lamotrigin and topiramate
22.1
10.0
14
7
AA1BD
NOMESCO Finland
Extensive CT of head and brain
19.3
9.6
14
8
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
32.6
9.6
12
*
C71.19
ICD-10 Finland
Malignant tumor of frontal lobe other or unspecified histology
107.2
9.5
10
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.1
9.5
41
130
G40
ICD-10 Finland
Epilepsy
+∞
9.5
9
*
C71.99
ICD-10 Finland
Malignant tumor in unspecified localization in the brain other or unspecified histology
+∞
9.5
9
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
9.3
8.9
18
22
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
53.5
8.8
10
*
G40.10
ICD-10 Finland
Simple partial seizures
29.7
8.6
11
*
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
+∞
8.4
8
*
9400/3-C71.0
ICD-O-3
Astrocytoma, NOS, of cerebrum
+∞
8.4
8
*
WX872
NOMESCO Finland
Intensive care
7.8
8.1
18
26
WZC30
NOMESCO Finland
Teaching
4.5
7.9
29
78
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
47.8
7.8
9
*
C71.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of brain
+∞
7.4
7
*
D43.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, unspecified
+∞
7.4
7
*
9400/3-C71.3
ICD-O-3
Astrocytoma, NOS, of parietal lobe
+∞
7.4
7
*
ZXM40
NOMESCO Finland
Use of fluorescent substance
+∞
7.4
7
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.0
7.2
48
207
R47.0
ICD-10 Finland
Dysphasia and aphasia
42.2
6.8
8
*
N05CD08
ATC
midazolam; nasal, systemic
23.9
6.8
9
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
15.3
6.5
10
7
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
15.3
6.5
10
7
N03AX23
ATC
brivaracetam; systemic
73.2
6.5
7
*
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
73.2
6.5
7
*
C71.00
ICD-10 Finland
Malignant tumor of the cerebrum except lobes and ventricles without histology
73.2
6.5
7
*
WX402
NOMESCO Finland
General anaesthesia
3.4
6.4
34
123
C71.40
ICD-10 Finland
Malignant tumor of the occipital lobe without histology
+∞
6.3
6
*
AA5NK
NOMESCO Finland
Tractography within white matter of central nervous system
+∞
6.3
6
*
C71.13
ICD-10 Finland
Malignant tumor of frontal lobe grade IV glioma
+∞
6.3
6
*
C71.23
ICD-10 Finland
Malignant tumor of temporal lobe grade IV glioma
+∞
6.3
6
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.7
6.1
27
86
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: C3_ASTROCYTOMA – Brain astrocytoma
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).