This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Brain glioblastoma and astrocytoma
C3_GBM_ASTROCYTOMA
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
578 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
578 |
4. Check minimum number of eventsNone |
578 |
5. Include endpoints |
578 |
6. Filter based on genotype QC (FinnGen only) |
578 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF9
Similar endpoints
↥List of similar endpoints to
Brain glioblastoma and astrocytoma
based on the number of shared cases.
Similar with more cases:
- Brain glioblastoma and astrocytoma, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm of brain
- Malignant neoplasm of eye, brain and central nervous system
- Malignant neoplasm of brain, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm of eye, brain and central nervous system, excluding all cancers (controls excluding all cancers)
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 578 | 248 | 330 |
| Unadjusted period prevalence (%) | 0.12 | 0.08 | 0.15 |
| Median age at first event (years) | 62.19 | 61.09 | 63.01 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 546
- Matched controls
- 5459
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB02
ATC
dexamethasone; systemic
98.2
323.0
456
267
L01AX03
ATC
temozolomide; systemic
1377.2
323.0
365
8
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
1846.3
323.0
413
9
130
Kela drug reimbursment
Malignant tumour
73.7
323.0
413
220
N03AX14
ATC
levetiracetam; systemic
101.7
266.7
283
57
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
51.4
239.5
292
119
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
34.6
219.4
301
187
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
94.5
205.4
221
39
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
408.0
198.3
188
7
C71.23
ICD-10 Finland
Malignant tumor of temporal lobe grade IV glioma
+∞
167.6
152
*
A04AA02
ATC
granisetron; systemic, transdermal
27.0
158.1
228
141
WF002
NOMESCO Finland
Radical radiotherapy
29.2
152.2
213
117
9440/3-C71.9
ICD-O-3
Glioblastoma, NOS, of brain, NOS
+∞
137.4
126
*
ZXC95
NOMESCO Finland
Use of surgical navigator
100.0
136.8
147
20
C71.13
ICD-10 Finland
Malignant tumor of frontal lobe grade IV glioma
+∞
135.2
124
*
C71.20
ICD-10 Finland
Malignant tumor in temporal lobe without histology
1614.8
134.2
125
*
C71.10
ICD-10 Finland
Malignant tumor in frontal lobe without histology
544.0
133.1
127
*
A03FA01
ATC
metoclopramide; systemic, rectal
10.8
132.0
323
643
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
129.0
130.1
136
14
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
269.3
126.7
125
6
Z51.5
ICD-10 Finland
Palliative care
19.2
115.5
186
143
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
39.8
114.5
145
49
WF003
NOMESCO Finland
Adjuvant radiotherapy
25.9
113.8
163
88
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
347.3
113.7
111
*
9440/3-C71.2
ICD-O-3
Glioblastoma, NOS, of temporal lobe
+∞
110.2
102
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
40.8
98.6
124
39
C71.2
ICD-10 Finland
Malignant neoplasm: Temporal lobe
1087.2
96.0
91
*
C71.1
ICD-10 Finland
Malignant neoplasm: Frontal lobe
1072.9
94.9
90
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
25.6
92.5
132
67
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
42.5
92.4
115
34
9440/3-C71.1
ICD-O-3
Glioblastoma, NOS, of frontal lobe
+∞
92.4
86
*
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
497.9
87.8
85
*
AA1AD
NOMESCO Finland
CT of head and brain
6.8
87.7
291
782
AAG00
NOMESCO Finland
Stereotactic intracranial biopsy
932.9
83.9
80
*
C71.33
ICD-10 Finland
Malignant tumor of parietal lobe grade IV glioma
+∞
81.3
76
*
XX3DW
NOMESCO Finland
Time consuming IT work
9.4
79.9
185
283
C71.11
ICD-10 Finland
Malignant tumor of frontal lobe grade II glioma
409.3
73.6
72
*
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
213.4
73.1
74
*
N03AX18
ATC
lacosamide; systemic
137.9
68.7
72
6
N03AF02
ATC
oxcarbazepine; oral
18.7
68.4
108
71
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
6.3
67.3
215
509
C71.30
ICD-10 Finland
Malignant tumor in parietal lobe without histology
371.8
66.0
65
*
A04AA01
ATC
ondansetron; systemic, rectal
10.7
65.7
136
164
ZX095
NOMESCO Finland
Combined chemoradiotherapy
87.2
62.7
69
9
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
+∞
61.6
58
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
9.2
61.6
140
198
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
76.1
59.8
67
10
ZXC40
NOMESCO Finland
Use of ultrasound
83.0
59.6
66
9
C71.21
ICD-10 Finland
Malignant tumor of temporal lobe grade II glioma
607.7
56.7
55
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
10.7
55.9
114
131
R56.8
ICD-10 Finland
Other and unspecified convulsions
10.4
55.3
115
137
WX882
NOMESCO Finland
High dependency care
16.6
51.3
84
59
9400/3-C71.9
ICD-O-3
Astrocytoma, NOS, of brain, NOS
+∞
50.8
48
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
58.8
49.8
58
11
9440/3-C71.3
ICD-O-3
Glioblastoma, NOS, of parietal lobe
+∞
49.8
47
*
9400/3-C71.1
ICD-O-3
Astrocytoma, NOS, of frontal lobe
+∞
48.7
46
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
13.1
47.8
87
78
C71.3
ICD-10 Finland
Malignant neoplasm: Parietal lobe
+∞
47.6
45
*
N74
ICPC
Malignant neoplasm nervous system
498.4
47.0
46
*
D43.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, unspecified
498.4
47.0
46
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
9.4
45.6
99
125
ZXM40
NOMESCO Finland
Use of fluorescent substance
474.6
44.9
44
*
C71.83
ICD-10 Finland
Overall malignant tumor of the brain grade IV glioma
462.8
43.8
43
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
163.1
43.5
45
*
A02BC02
ATC
pantoprazole; systemic
3.8
42.4
425
2605
C71.99
ICD-10 Finland
Malignant tumor in unspecified localization in the brain other or unspecified histology
119.4
41.4
44
*
XA800
NOMESCO Finland
Neuropsychological investigation
10.2
39.9
82
93
C71.29
ICD-10 Finland
Malignant tumor in temporal lobe other or unspecified histology
416.0
39.6
39
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.4
37.6
267
1210
AA1BD
NOMESCO Finland
Extensive CT of head and brain
15.4
37.1
62
45
G40.9
ICD-10 Finland
Epilepsy, unspecified
10.1
37.0
76
86
N03AB02
ATC
phenytoin; systemic
28.2
36.1
49
19
N02AA05
ATC
oxycodone; systemic
4.5
34.5
141
396
N05CD08
ATC
midazolam; nasal, systemic
15.5
33.7
56
40
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
16.2
32.5
53
36
A28
ICPC
Limited function/disability NOS
4.1
30.3
133
395
C71.22
ICD-10 Finland
Malignant tumor of temporal lobe grade III glioma
319.2
30.1
30
*
C71.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of brain
+∞
29.4
28
*
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
46.6
29.0
35
8
WZC30
NOMESCO Finland
Teaching
3.9
28.9
134
416
C71.12
ICD-10 Finland
Malignant tumor of frontal lobe grade III glioma
295.9
28.0
28
*
WX402
NOMESCO Finland
General anaesthesia
3.6
27.6
148
517
C71.93
ICD-10 Finland
Malignant tumor in an unspecified localization in the brain grade IV glioma
284.4
27.0
27
*
N05BA09
ATC
clobazam; oral
101.9
26.9
29
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
31.0
26.6
35
12
WX872
NOMESCO Finland
Intensive care
6.5
26.5
72
125
ZX070
NOMESCO Finland
Intensity modified radiotherapy
13.9
26.1
45
35
C71.19
ICD-10 Finland
Malignant tumor of frontal lobe other or unspecified histology
272.9
25.9
26
*
C71.00
ICD-10 Finland
Malignant tumor of the cerebrum except lobes and ventricles without histology
272.9
25.9
26
*
AAA10
NOMESCO Finland
Biopsy through craniotomy
141.7
25.8
27
*
ZXE20
NOMESCO Finland
More than three and less than five hours
3.5
24.3
129
441
C71.40
ICD-10 Finland
Malignant tumor of the occipital lobe without histology
+∞
24.1
23
*
A98
ICPC
Health maint/preventive medicine
0.3
24.1
383
4795
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
17.2
23.5
37
23
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
26.0
23.3
32
13
C71.43
ICD-10 Finland
Malignant tumor of the occipital lobe grade IV glioma
+∞
23.1
22
*
9400/3-C71.2
ICD-O-3
Astrocytoma, NOS, of temporal lobe
+∞
22.0
21
*
C71.80
ICD-10 Finland
Overall malignant tumor of the brain without histology
+∞
22.0
21
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.2
21.0
124
456
H53.4
ICD-10 Finland
Visual field defects
9.1
20.8
44
52
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
218.0
20.7
21
*
G40.10
ICD-10 Finland
Simple partial seizures
28.3
20.2
27
10
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
24.5
20.1
28
12
9440/3-C71.0
ICD-O-3
Glioblastoma, NOS, of cerebrum
+∞
19.9
19
*
C71.03
ICD-10 Finland
Malignant tumor of cerebellum except lobes and ventricles grade IV glioma
+∞
19.9
19
*
C71.01
ICD-10 Finland
Malignant tumor of cerebellum except lobes and ventricles grade II glioma
207.2
19.7
20
*
N76
ICPC
Neoplasm nervous system unspecified
207.2
19.7
20
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.8
19.6
151
658
A79
ICPC
Malignancy NOS
19.1
19.3
29
16
N03AG01
ATC
valproic acid; systemic, rectal
4.6
18.9
69
168
C71.31
ICD-10 Finland
Malignant tumor of the parietal lobe grand II glioma
+∞
18.9
18
*
N05CF01
ATC
zopiclone; oral
2.4
18.4
204
1085
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
20.2
18.4
27
14
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
29.9
17.5
23
8
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
16.6
17.2
27
17
C71.9
ICD-10 Finland
Malignant neoplasm: Brain, unspecified
93.0
16.7
18
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
11.7
16.4
30
27
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
7.8
15.7
36
49
G41.9
ICD-10 Finland
Status epilepticus, unspecified
22.9
15.7
22
10
R90.0
ICD-10 Finland
Intracranial space-occupying lesion
164.5
15.6
16
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
6.8
15.2
38
59
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
15.2
179
960
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
14.5
15.2
25
18
R4120
NOMESCO Finland
Occupational therapy
3.9
15.0
63
175
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
14.9
147
720
9440/3-C71.8
ICD-O-3
Glioblastoma, NOS, of overlapping lesion of brain
+∞
14.6
14
*
N03AX23
ATC
brivaracetam; systemic
154.0
14.5
15
*
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
37.1
14.5
18
5
N03AF01
ATC
carbamazepine; oral, rectal
4.6
14.5
51
120
WC105
NOMESCO Finland
Simple cytostatic therapy of local tumor recidive
30.9
14.0
18
6
183
Kela drug reimbursment
Lamotrigin and topiramate
18.1
13.9
21
12
R4150
NOMESCO Finland
Neuropsychological rehabilitation
14.1
13.8
23
17
C71.32
ICD-10 Finland
Malignant tumor of parietal lobe grade III glioma
+∞
13.6
13
*
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
11.9
13.4
24
21
WF004
NOMESCO Finland
Palliative radiotherapy
8.4
13.0
28
35
WF029
NOMESCO Finland
Radiotherapy of local residive tumor
15.9
12.7
20
13
9440/3-C71.4
ICD-O-3
Glioblastoma, NOS, of occipital lobe
+∞
12.5
12
*
WX704
NOMESCO Finland
Intubation
3.4
12.5
61
192
H02AB09
ATC
hydrocortisone; systemic
7.2
12.3
29
42
YX8AD
NOMESCO Finland
Stereotactic CT examination for dose design of radiotherapy
66.4
11.6
13
*
N05BA04
ATC
oxazepam; oral
2.2
11.5
142
765
C71.39
ICD-10 Finland
Malignant tumor of parietal lobe other or unspecified histology
122.5
11.5
12
*
XA400
NOMESCO Finland
EEG
28.7
10.8
14
5
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
13.2
10.7
18
14
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.1
10.6
60
210
C71.4
ICD-10 Finland
Malignant neoplasm: Occipital lobe
112.1
10.5
11
*
G40.11
ICD-10 Finland
Simple partial epileptic seizure that develops into a complex partial seizure
40.9
10.0
12
*
R4130
NOMESCO Finland
Speech therapy
5.9
9.9
27
48
C71.81
ICD-10 Finland
Overall malignant tumor of the brain grade II glioma
101.7
9.4
10
*
R47.0
ICD-10 Finland
Dysphasia and aphasia
8.3
9.4
20
25
G93.6
ICD-10 Finland
Cerebral oedema
+∞
9.4
9
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
9.3
69
287
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
9.2
104
535
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.3
9.2
45
143
R4110
NOMESCO Finland
Physiotherapy
1.9
9.1
158
963
G41.2
ICD-10 Finland
Complex partial status epilepticus
37.3
9.0
11
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
0.4
8.9
32
791
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
9.7
8.8
17
18
Z73.3
ICD-10 Finland
Stress, not elsewhere classified
9.7
8.8
17
18
WX110
NOMESCO Finland
Local anesthesy
1.8
8.8
365
2921
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.3
8.7
43
138
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
8.5
209
1419
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
20.4
8.5
12
6
WX725
NOMESCO Finland
Noninvasive ventilation
3.5
8.4
39
119
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
91.4
8.4
9
*
C71
ICD-10 Finland
Malignant neoplasm of brain
91.4
8.4
9
*
R83
ICPC
Respiratory infection other
0.4
8.4
30
744
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
+∞
8.4
8
*
C71.02
ICD-10 Finland
Malignant tumor of the cerebrum except lobes and ventricles grade III glioma
+∞
8.4
8
*
9400/3-C71.0
ICD-O-3
Astrocytoma, NOS, of cerebrum
+∞
8.4
8
*
JN4BD
NOMESCO Finland
Extensive body CT
2.4
8.2
70
315
D69.5
ICD-10 Finland
Secondary thrombocytopenia
33.9
8.1
10
*
TKC20
NOMESCO Finland
Catheterisation of bladder
2.9
8.1
50
185
N19
ICPC
Speech disorder
13.3
7.9
13
10
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
0.5
7.8
96
1557
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
4.1
7.8
29
74
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
4.6
7.7
25
56
SAA01
NOMESCO Finland
Simple examination of mouth
0.6
7.5
228
2963
B01AB10
ATC
tinzaparin; parenteral
2.6
7.4
51
205
C71.0
ICD-10 Finland
Malignant neoplasm: Cerebrum, except lobes and ventricles
+∞
7.3
7
*
C71.50
ICD-10 Finland
Malignant tumor of cerebral ventricle without histology
+∞
7.3
7
*
9400/3-C71.3
ICD-O-3
Astrocytoma, NOS, of parietal lobe
+∞
7.3
7
*
U07.2
ICD-10 Finland
COVID-19, virus not identified
0.3
7.2
16
491
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.4
7.1
61
274
205
Kela drug reimbursment
Chronic hypertension
0.5
7.0
51
975
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
5.6
7.0
19
35
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
14.0
6.9
11
8
SAA02
NOMESCO Finland
Basic examination of mouth
0.6
6.9
194
2584
R51.80
ICD-10 Finland
Headache
2.1
6.9
78
401
WX892
NOMESCO Finland
Monitored bed care
2.6
6.8
50
205
R41.0
ICD-10 Finland
Disorientation, unspecified
4.2
6.8
24
59
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.5
6.7
22
50
M25.5
ICD-10 Finland
Pain in joint
0.5
6.5
52
966
C71.09
ICD-10 Finland
Malignant tumor of the cerebrum except lobes and ventricles other or unspecified histology
70.6
6.4
7
*
2151
FHL
Resection, big brain
70.6
6.4
7
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
6.3
61
292
AA003
NOMESCO Finland
Adjuvant radiotherapy of brain
+∞
6.3
6
*
C71.91
ICD-10 Finland
Malignant tumor in unspecified location in the brain grade II glioma
+∞
6.3
6
*
C71.82
ICD-10 Finland
Overall malignant tumor of the brain grade III glioma
+∞
6.3
6
*
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.7
6.3
40
153
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.9
6.2
36
130
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
4.6
6.2
20
45
M75.1
ICD-10 Finland
Rotator cuff syndrome
0.5
6.2
38
769
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: C3_GBM_ASTROCYTOMA – Brain glioblastoma and astrocytoma
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).