This is a non-core endpoint: only basic statistics are computed.
See its core counterpart C3_GBM_EXALLC for full statistics.
Brain glioblastoma
C3_GBM
brain glioblastoma: A WHO grade IV malignant astrocytic tumor that arises from the brain, usually the cerebral hemispheres. It is characterized by the presence of poorly differentiated astrocytes, cellular polymorphism, nuclear atypia, and increased mitotic activity. The prognosis is poor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
435 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
435 |
4. Check minimum number of eventsNone |
435 |
5. Include endpoints |
435 |
6. Filter based on genotype QC (FinnGen only) |
435 |
Control definitions (FinnGen only)
- Control conditions
- not HLP_C3_GBM
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF8
Similar endpoints
↥List of similar endpoints to
Brain glioblastoma
based on the number of shared cases.
Similar with more cases:
- Brain glioblastoma, excluding all cancers (controls excluding all cancers)
- Brain glioblastoma and astrocytoma
- Brain glioblastoma and astrocytoma, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm of brain
- Malignant neoplasm of eye, brain and central nervous system
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 435 | 177 | 258 |
| Unadjusted period prevalence (%) | 0.09 | 0.06 | 0.11 |
| Median age at first event (years) | 65.80 | 66.18 | 65.54 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 411
- Matched controls
- 4107
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
864.8
323.0
313
15
L01AX03
ATC
temozolomide; systemic
1354.8
321.9
273
6
H02AB02
ATC
dexamethasone; systemic
115.9
306.6
362
246
130
Kela drug reimbursment
Malignant tumour
61.4
248.3
311
198
N03AX14
ATC
levetiracetam; systemic
93.8
190.9
205
43
C71.23
ICD-10 Finland
Malignant tumor of temporal lobe grade IV glioma
2251.5
161.7
146
*
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
245.0
147.6
144
9
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
36.4
141.0
186
91
9440/3-C71.9
ICD-O-3
Glioblastoma, NOS, of brain, NOS
+∞
139.8
126
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
24.7
136.1
207
162
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
68.0
131.4
149
34
C71.13
ICD-10 Finland
Malignant tumor of frontal lobe grade IV glioma
+∞
130.3
118
*
9440/3-C71.2
ICD-O-3
Glioblastoma, NOS, of temporal lobe
+∞
111.7
102
*
Z51.5
ICD-10 Finland
Palliative care
23.4
108.8
164
113
A04AA02
ATC
granisetron; systemic, transdermal
21.3
104.3
163
123
WF002
NOMESCO Finland
Radical radiotherapy
20.3
103.6
165
131
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
98.3
101.4
109
15
C71.20
ICD-10 Finland
Malignant tumor in temporal lobe without histology
610.2
100.0
95
*
A03FA01
ATC
metoclopramide; systemic, rectal
10.7
99.2
246
503
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
207.9
95.8
96
6
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
158.1
94.7
97
8
9440/3-C71.1
ICD-O-3
Glioblastoma, NOS, of frontal lobe
+∞
93.4
86
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
27.9
92.8
130
67
ZXC95
NOMESCO Finland
Use of surgical navigator
73.9
90.1
101
18
C71.2
ICD-10 Finland
Malignant neoplasm: Temporal lobe
+∞
85.5
79
*
C71.33
ICD-10 Finland
Malignant tumor of parietal lobe grade IV glioma
+∞
81.0
75
*
C71.1
ICD-10 Finland
Malignant neoplasm: Frontal lobe
+∞
79.8
74
*
C71.10
ICD-10 Finland
Malignant tumor in frontal lobe without histology
911.7
79.1
75
*
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
168.1
68.3
70
5
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
23.9
65.4
95
51
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
185.4
61.9
63
*
AAG00
NOMESCO Finland
Stereotactic intracranial biopsy
233.4
59.8
60
*
C71.30
ICD-10 Finland
Malignant tumor in parietal lobe without histology
+∞
58.8
55
*
ZX095
NOMESCO Finland
Combined chemoradiotherapy
75.5
57.2
64
10
AA1AD
NOMESCO Finland
CT of head and brain
5.8
56.5
215
654
XX3DW
NOMESCO Finland
Time consuming IT work
8.3
55.9
139
237
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
17.5
54.3
88
63
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
31.5
53.4
71
27
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
11.7
51.0
100
110
9440/3-C71.3
ICD-O-3
Glioblastoma, NOS, of parietal lobe
+∞
50.0
47
*
A04AA01
ATC
ondansetron; systemic, rectal
10.5
48.7
101
123
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
23.0
46.8
68
35
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
5.8
46.7
160
408
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
172.1
44.8
46
*
C71.3
ICD-10 Finland
Malignant neoplasm: Parietal lobe
+∞
44.6
42
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
40.3
42.5
53
15
C71.83
ICD-10 Finland
Overall malignant tumor of the brain grade IV glioma
+∞
42.4
40
*
D43.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, unspecified
+∞
41.4
39
*
N03AX18
ATC
lacosamide; systemic
42.5
39.8
49
13
N74
ICPC
Malignant neoplasm nervous system
151.4
39.5
41
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
55.9
38.5
45
9
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
8.8
35.7
81
112
C71.99
ICD-10 Finland
Malignant tumor in unspecified localization in the brain other or unspecified histology
377.9
35.5
35
*
ZXM40
NOMESCO Finland
Use of fluorescent substance
135.2
35.3
37
*
ZXC40
NOMESCO Finland
Use of ultrasound
63.0
34.9
40
7
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
6.8
33.6
92
168
WX882
NOMESCO Finland
High dependency care
12.4
33.6
62
58
N03AF02
ATC
oxcarbazepine; oral
13.6
32.9
58
49
N02AA05
ATC
oxycodone; systemic
4.7
30.7
121
337
N05CD08
ATC
midazolam; nasal, systemic
18.1
30.2
47
29
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
54.4
29.9
35
7
A02BC02
ATC
pantoprazole; systemic
3.7
28.8
325
2089
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
8.2
28.0
65
92
AA1BD
NOMESCO Finland
Extensive CT of head and brain
14.2
27.9
48
38
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.2
26.5
192
873
R56.8
ICD-10 Finland
Other and unspecified convulsions
7.7
26.5
64
96
C71.29
ICD-10 Finland
Malignant tumor in temporal lobe other or unspecified histology
+∞
26.3
25
*
C71.93
ICD-10 Finland
Malignant tumor in an unspecified localization in the brain grade IV glioma
277.1
26.0
26
*
WX402
NOMESCO Finland
General anaesthesia
4.1
25.4
114
352
A28
ICPC
Limited function/disability NOS
3.9
24.3
115
371
G40.9
ICD-10 Finland
Epilepsy, unspecified
10.6
22.4
44
46
A98
ICPC
Health maint/preventive medicine
0.3
22.3
268
3531
C71.43
ICD-10 Finland
Malignant tumor of the occipital lobe grade IV glioma
+∞
22.1
21
*
C71.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of brain
+∞
22.1
21
*
WZC30
NOMESCO Finland
Teaching
3.7
21.2
105
348
C71.00
ICD-10 Finland
Malignant tumor of the cerebrum except lobes and ventricles without histology
+∞
20.0
19
*
9440/3-C71.0
ICD-O-3
Glioblastoma, NOS, of cerebrum
+∞
20.0
19
*
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
24.0
19.3
27
12
C71.03
ICD-10 Finland
Malignant tumor of cerebellum except lobes and ventricles grade IV glioma
+∞
18.9
18
*
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
11.5
17.8
33
31
ZX070
NOMESCO Finland
Intensity modified radiotherapy
10.2
17.8
35
37
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.1
16.7
106
414
AAA10
NOMESCO Finland
Biopsy through craniotomy
176.9
16.6
17
*
N03AB02
ATC
phenytoin; systemic
16.2
16.4
26
17
N05CF01
ATC
zopiclone; oral
2.5
16.1
173
928
C71.80
ICD-10 Finland
Overall malignant tumor of the brain without histology
88.5
15.7
17
*
C71.9
ICD-10 Finland
Malignant neoplasm: Brain, unspecified
166.1
15.6
16
*
C71.19
ICD-10 Finland
Malignant tumor of frontal lobe other or unspecified histology
166.1
15.6
16
*
ZXE20
NOMESCO Finland
More than three and less than five hours
3.1
15.6
97
372
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
15.6
15.6
25
17
WX872
NOMESCO Finland
Intensive care
4.7
15.3
54
129
A79
ICPC
Malignancy NOS
14.7
15.2
25
18
9440/3-C71.8
ICD-O-3
Glioblastoma, NOS, of overlapping lesion of brain
+∞
14.7
14
*
C71.22
ICD-10 Finland
Malignant tumor of temporal lobe grade III glioma
155.3
14.6
15
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
14.4
123
573
WF004
NOMESCO Finland
Palliative radiotherapy
11.5
14.2
26
24
C71.40
ICD-10 Finland
Malignant tumor of the occipital lobe without histology
44.2
14.2
17
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.7
14.1
110
484
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
55.3
13.9
16
*
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
55.3
13.9
16
*
R4120
NOMESCO Finland
Occupational therapy
4.5
13.8
50
123
N76
ICPC
Neoplasm nervous system unspecified
144.6
13.5
14
*
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
17.4
13.1
20
12
XA800
NOMESCO Finland
Neuropsychological investigation
5.6
12.9
38
74
G40.10
ICD-10 Finland
Simple partial seizures
33.2
12.7
16
5
9440/3-C71.4
ICD-O-3
Glioblastoma, NOS, of occipital lobe
+∞
12.6
12
*
R90.0
ICD-10 Finland
Intracranial space-occupying lesion
+∞
12.6
12
*
H53.4
ICD-10 Finland
Visual field defects
7.3
12.3
29
42
G41.9
ICD-10 Finland
Status epilepticus, unspecified
13.9
12.1
20
15
N05BA09
ATC
clobazam; oral
36.1
11.3
14
*
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
17.7
11.3
17
10
WX704
NOMESCO Finland
Intubation
3.7
10.7
48
143
C71.21
ICD-10 Finland
Malignant tumor of temporal lobe grade II glioma
112.8
10.5
11
*
C71.4
ICD-10 Finland
Malignant neoplasm: Occipital lobe
+∞
10.5
10
*
C71.39
ICD-10 Finland
Malignant tumor of parietal lobe other or unspecified histology
+∞
10.5
10
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
5.7
10.3
29
54
B01AB10
ATC
tinzaparin; parenteral
3.5
10.3
49
154
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
17.2
9.9
15
9
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
9.9
9.9
19
20
C71.12
ICD-10 Finland
Malignant tumor of frontal lobe grade III glioma
+∞
9.4
9
*
C71.32
ICD-10 Finland
Malignant tumor of parietal lobe grade III glioma
+∞
9.4
9
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
11.0
9.4
17
16
N03AG01
ATC
valproic acid; systemic, rectal
3.9
9.3
38
105
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.1
9.3
36
95
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
11.0
8.9
16
15
WX725
NOMESCO Finland
Noninvasive ventilation
4.3
8.8
32
80
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
16.7
8.6
13
8
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
8.5
131
775
C71.01
ICD-10 Finland
Malignant tumor of cerebellum except lobes and ventricles grade II glioma
91.9
8.4
9
*
TKC20
NOMESCO Finland
Catheterisation of bladder
3.2
8.2
42
140
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
8.4
8.2
17
21
N05BA04
ATC
oxazepam; oral
2.1
8.1
112
633
WC105
NOMESCO Finland
Simple cytostatic therapy of local tumor recidive
17.6
8.1
12
7
SAA02
NOMESCO Finland
Basic examination of mouth
0.5
7.9
130
1896
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
8.7
7.9
16
19
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
7.8
85
435
R4110
NOMESCO Finland
Physiotherapy
2.0
7.7
122
725
R41.0
ICD-10 Finland
Disorientation, unspecified
5.2
7.5
22
44
G93.6
ICD-10 Finland
Cerebral oedema
81.5
7.4
8
*
SPAT1245
SPAT
Provision of support and information to patient’s family members
4.0
7.4
28
73
C71.0
ICD-10 Finland
Malignant neoplasm: Cerebrum, except lobes and ventricles
+∞
7.3
7
*
C71
ICD-10 Finland
Malignant neoplasm of brain
+∞
7.3
7
*
JN4BD
NOMESCO Finland
Extensive body CT
2.4
7.3
62
282
H02AB09
ATC
hydrocortisone; systemic
6.2
7.2
18
30
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
4.1
7.1
26
66
WX110
NOMESCO Finland
Local anesthesy
1.8
7.1
271
2145
SAA01
NOMESCO Finland
Simple examination of mouth
0.6
6.9
159
2157
205
Kela drug reimbursment
Chronic hypertension
0.4
6.8
44
866
SFA10
NOMESCO Finland
Fillning on one surface of tooth
0.5
6.8
101
1534
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
0.4
6.8
27
638
N03AX23
ATC
brivaracetam; systemic
40.7
6.8
8
*
Z25.8
ICD-10 Finland
Need for immunization against other specified single viral diseases
0.1
6.6
*
262
XA400
NOMESCO Finland
EEG
12.5
6.6
11
9
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
0.5
6.6
44
853
TPH07
NOMESCO Finland
Cathetrisation of artery
2.4
6.5
54
242
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
6.5
160
1099
G41.2
ICD-10 Finland
Complex partial status epilepticus
70.9
6.4
7
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
5.1
6.4
19
39
WF029
NOMESCO Finland
Radiotherapy of local residive tumor
18.4
6.3
9
5
C71.50
ICD-10 Finland
Malignant tumor of cerebral ventricle without histology
+∞
6.3
6
*
G40.11
ICD-10 Finland
Simple partial epileptic seizure that develops into a complex partial seizure
27.1
6.2
8
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
0.4
6.2
29
644
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
12.8
6.1
10
8
R47.0
ICD-10 Finland
Dysphasia and aphasia
8.8
6.1
12
14
WX892
NOMESCO Finland
Monitored bed care
2.7
6.1
42
169
M25.5
ICD-10 Finland
Pain in joint
0.4
6.0
37
744
R83
ICPC
Respiratory infection other
0.3
6.0
15
436
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: C3_GBM – Brain glioblastoma
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).