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Carcinoma in situ of endometrium

CD2_INSITU_ENDOMETRIUM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D07.0&
  • Hospital discharge: ICD-9 2332
  • Cause of death: ICD-10 D07.0&
  • Cause of death: ICD-9 2332

2 out of 7 registries used, show all original rules.

157

4. Check minimum number of events

None

157

5. Include endpoints

None

157

6. Filter based on genotype QC (FinnGen only)

157

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D07
Name in latin
Carcinoma in situ endometrii (corporis uteri)

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 157 157 -
Unadjusted period prevalence (%) 0.05 0.05 -
Median age at first event (years) 62.28 62.28 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
140
Matched controls
1399
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D07.0
ICD-10 Finland
Carcinoma in situ: Endometrium
+∞
199.1
139
*
LCD01
NOMESCO Finland
Total laparoscopic hysterectomy
75.9
63.4
70
18
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
62.0
63.3
73
24
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
33.0
61.1
86
64
PJA01
NOMESCO Finland
Laparoscopic sentinel node excision
192.0
50.7
50
*
8380/3-C54.1
ICD-O-3
Endometrioid adenocarcinoma, NOS, of endometrium
59.8
46.1
53
14
N85.1
ICD-10 Finland
Endometrial adenomatous hyperplasia
79.8
32.9
36
6
N95.0
ICD-10 Finland
Postmenopausal bleeding
9.2
26.8
65
120
ZXC96
NOMESCO Finland
Robot assisted procedure
43.2
23.1
28
8
B01AB10
ATC
tinzaparin; parenteral
10.2
20.5
43
58
LCB25
NOMESCO Finland
Hysteroscopic excision of lesion
11.6
20.2
39
45
N84.0
ICD-10 Finland
Polyp of corpus uteri
8.0
19.6
49
88
N85.0
ICD-10 Finland
Endometrial glandular hyperplasia
27.2
15.6
21
9
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
6.1
11.6
33
67
8380/3-C54.9
ICD-O-3
Endometrioid adenocarcinoma, NOS, of corpus uteri
38.5
11.5
14
*
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
22.3
11.4
16
8
JN4BD
NOMESCO Finland
Extensive body CT
5.0
10.8
37
94
B01AB05
ATC
enoxaparin; parenteral
3.4
10.5
70
318
SPAT1312
SPAT
General health counselling
3.2
9.6
72
348
ZX040
NOMESCO Finland
Intracavity HDR radiotherapy
39.5
9.2
11
*
LCA06
NOMESCO Finland
Biopsy of endometrium
3.9
9.1
41
134
C54.10
ICD-10 Finland
Malignant tumor of endometrium without histology
53.4
8.8
10
*
SPAT1301
SPAT
No procedures
3.0
8.5
67
327
SPAT1249
SPAT
Treatment-related counselling outside office
2.9
8.3
79
435
LCA13
NOMESCO Finland
Curettage of cervix and body of uterus
4.6
7.7
27
69
ULC02
NOMESCO Finland
Hysteroscopy
5.1
7.6
24
55
SPAT1153
SPAT
Removal of sutures
2.8
7.4
64
326
WF090
NOMESCO Finland
Profylactic radiotherapy
42.2
6.8
8
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.6
6.7
62
324
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
4.7
6.7
22
53
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.1
6.7
26
74
-
ICD-10 Finland
NA
10.8
6.7
12
12
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
11.8
6.4
11
10
WF003
NOMESCO Finland
Adjuvant radiotherapy
5.7
6.3
17
33
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.8
6.2
20
47
WX408
NOMESCO Finland
General anesthesy, balanced
0.1
6.2
*
240

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
74
123
10.49
47.79
4.3
3.2
—
—
—
0
0
39
41
12.33
34.78
3.2
4.7
3.8
3.8
mmol/l
0.10
39
35
41
47
11.45
34.42
3.3
4.9
—
—
—
0
0
110
371
7.56
33.94
5.6
4.6
0.0
0.0
estimate
0.00
16
133
100
331
6.57
30.72
6.0
4.1
—
—
—
0
0
58
128
6.60
27.23
1.4
2.2
0.2
0.2
g/l
2.60
58
121
43
85
6.59
22.22
5.7
7.9
24.6
25.7
mmol/l
1.37
43
79
39
70
7.08
22.13
3.2
7.7
95.0
94.8
%
0.18
39
70
44
91
6.33
21.68
3.0
5.1
—
—
—
0
0
109
540
4.33
16.93
6.1
4.0
—
—
—
0
0
44
123
4.58
14.98
3.1
6.9
123.7
119.4
g/l
0.67
44
118
124
708
4.57
14.97
5.8
4.2
0.0
0.0
estimate
0.50
16
126
122
698
4.35
14.45
5.9
4.1
0.0
0.0
estimate
0.00
16
131
121
704
4.13
13.61
6.4
5.6
0.0
0.0
estimate
0.00
13
127
46
149
3.95
12.69
3.2
6.4
13.3
12.5
kpa
0.41
46
143
46
149
3.95
12.69
3.2
6.4
5.2
5.3
kpa
0.11
46
143
43
133
4.08
12.64
3.2
6.5
97.8
96.3
%
2.98
43
125
116
679
3.71
12.41
4.5
3.7
—
—
—
0
0
46
153
3.84
12.17
3.1
6.3
1.3
1.8
mmol/l
0.77
34
128
106
623
3.16
10.53
3.4
3.7
37.1
35.5
g/l
3.10
98
578
44
158
3.48
10.23
3.5
5.5
104.2
103.4
mmol/l
0.61
44
151
38
132
3.48
9.23
2.0
1.5
—
—
—
0
0
17
38
4.90
7.38
22.1
8.4
—
—
—
0
0
12
432
0.22
7.02
4.1
5.3
—
—
—
0
0
132
995
3.05
6.48
5.4
3.9
—
—
—
0
0
87
1131
0.48
4.70
10.2
17.4
14.3
13.7
%
2.10
82
1111
123
978
2.19
4.02
5.4
4.9
—
69.1
—
0
14
76
520
1.89
3.76
4.8
3.5
18.5
32.4
ng/l
0.83
55
365
58
369
1.91
3.54
5.5
7.0
—
—
—
0
0
56
360
1.86
3.27
1.2
1.3
—
—
—
0
0
102
1208
0.56
2.93
8.1
15.3
41.2
39.0
%
3.05
36
833
80
589
1.73
2.88
2.3
2.1
—
—
—
0
0
22
407
0.47
2.86
1.5
1.6
1.6
1.3
mmol/l
0.51
17
335
152
1403
3.62
2.74
14.5
13.1
—
—
—
0
0
131
1122
2.01
2.73
5.5
4.4
15.4
14.9
pmol/l
1.65
122
1017
23
411
0.48
2.68
2.3
3.1
22.0
31.4
e6/l
0.40
18
315
49
320
1.77
2.65
4.2
4.4
—
—
—
0
0
86
663
1.66
2.48
3.5
4.8
1.2
1.2
mmol/l
6.52
77
592
30
173
1.91
2.39
69.0
18.5
—
1.3
—
0
29
5
9
5.69
2.23
4.0
1.3
—
—
—
0
0
27
422
0.57
1.96
4.1
3.7
—
—
—
0
0
7
167
0.39
1.93
1.4
1.5
—
—
—
0
0
70
538
1.54
1.90
3.5
3.1
—
—
—
0
0
97
801
1.55
1.89
4.0
4.2
6.8
6.6
mmol/l
0.52
92
744
20
336
0.54
1.85
1.9
3.2
85.5
95.3
%
0.69
20
325
56
412
1.56
1.83
2.9
2.9
25.9
206.2
mg/l
0.51
34
232
35
500
0.61
1.76
2.4
3.7
20.0
113.8
e6/l
3.26
27
348
146
1349
2.17
1.73
15.8
13.9
26.3
21.4
mg/l
0.66
123
1048
29
429
0.60
1.67
2.9
3.0
—
—
—
0
0
25
382
0.59
1.63
3.8
3.8
—
—
—
0
0
20
322
0.57
1.58
1.3
1.2
0.7
1.5
u/ml
—
9
87
7
151
0.44
1.53
1.4
1.4
—
—
—
0
0
55
421
1.47
1.45
2.8
2.8
7.0
6.3
mmol/l
0.70
49
332
96
817
1.45
1.44
6.6
8.9
4.1
4.0
e9/l
0.16
89
717
57
441
1.46
1.42
3.4
3.6
7.0
5.6
mg/mmol
0.09
35
240
150
1424
2.20
1.41
18.0
16.4
71.2
69.8
umol/l
0.29
150
1424
0
38
0.00
1.36
0.0
3.5
—
35.0
—
0
31
138
1273
1.69
1.34
4.6
4.1
1.4
1.2
mmol/l
1.37
125
1148
144
1346
1.84
1.30
5.4
4.7
6.2
5.9
mmol/l
2.85
136
1234
22
140
1.66
1.29
1.3
1.7
—
—
—
0
0
139
1288
1.69
1.28
6.6
5.8
41.1
39.6
mmol/mol
1.03
130
1187
18
110
1.72
1.21
1.5
1.5
—
—
—
0
0
146
1376
1.87
1.19
5.7
5.2
2.9
2.8
mmol/l
0.32
134
1258
5
22
2.31
1.04
1.0
1.1
—
—
—
0
0
41
315
1.41
1.03
1.5
1.6
0.7
1.0
mg/l
1.08
31
241
15
92
1.70
1.01
1.3
1.3
—
—
—
0
0
0
29
0.00
0.99
0.0
2.8
—
—
—
0
0
0
30
0.00
0.98
0.0
3.9
—
—
—
0
0
0
30
0.00
0.98
0.0
1.6
—
1.3
—
0
23
11
62
1.83
0.97
1.6
2.3
1.3
1.1
%
0.41
11
62
28
203
1.46
0.96
1.5
2.0
—
—
—
0
0
142
1348
1.56
0.85
5.1
4.6
4.8
4.8
mmol/l
0.24
131
1235
138
1305
1.47
0.81
6.4
5.4
2.7
1.9
mu/l
0.85
129
1189
0
25
0.00
0.80
0.0
1.7
—
—
—
0
0
0
26
0.00
0.79
0.0
2.3
—
5.4
—
0
26
0
26
0.00
0.79
0.0
2.9
—
63.6
—
0
26
0
26
0.00
0.79
0.0
1.1
—
—
—
0
0
53
624
0.77
0.78
1.9
2.0
95.2
100.5
pmol/l
0.48
37
274
117
1081
1.32
0.77
5.3
7.2
80.2
78.0
u/l
0.18
111
992
9
57
1.61
0.72
1.3
1.2
—
—
—
0
0
41
335
1.30
0.70
3.3
3.6
—
—
—
0
0
12
78
1.58
0.67
1.4
1.3
—
—
—
0
0
10
63
1.63
0.63
1.6
3.2
24.9
25.7
mmol/l
—
10
63
53
611
0.80
0.62
7.9
9.0
0.0
0.0
e9/l
0.38
47
501
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
52
446
1.25
0.60
1.9
2.0
—
—
—
0
0
0
22
0.00
0.60
0.0
1.3
—
—
—
0
0
0
22
0.00
0.60
0.0
1.3
—
—
—
0
0
0
23
0.00
0.59
0.0
1.8
—
—
—
0
0
0
23
0.00
0.59
0.0
1.5
—
—
—
0
0
139
1333
1.37
0.57
4.9
4.6
1.5
1.6
mmol/l
2.28
127
1215
31
373
0.79
0.52
2.6
2.9
—
—
—
0
0
24
190
1.31
0.52
1.4
1.6
26.8
29.0
s
1.62
24
182
7
110
0.62
0.50
2.3
4.4
—
—
—
0
0
37
313
1.24
0.48
2.1
2.4
326.1
10017.1
umol/l
2.51
31
265
5
81
0.60
0.47
1.0
1.8
1.2
1.6
g/l
—
5
73
8
59
1.37
0.41
1.5
5.0
1.5
1.6
%
—
8
54
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
7
105
0.65
0.41
1.3
2.6
9.4
10.2
g/l
—
7
97
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
2.8
—
2.6
—
0
12
12
157
0.74
0.38
1.2
1.8
50.0
129.1
ug/g
1.43
12
119
10
132
0.74
0.33
1.4
1.4
—
—
—
0
0
38
336
1.17
0.32
2.3
2.1
4.9
3.3
mg/l
1.70
33
282
33
289
1.18
0.31
1.5
1.6
477.2
480.0
pmol/l
0.02
26
233
23
195
1.21
0.30
1.0
1.2
—
—
—
0
0
31
273
1.17
0.28
1.2
1.3
12.3
11.1
u/ml
0.04
21
101
51
469
1.13
0.25
2.7
3.4
7.4
7.4
ph
—
7
85
14
169
0.81
0.25
1.2
1.2
—
—
—
0
0
6
81
0.73
0.25
1.7
1.3
—
—
—
0
0
58
539
1.12
0.24
2.9
3.2
2.4
2.4
mmol/l
0.45
52
459
6
85
0.69
0.24
1.3
1.3
—
—
—
0
0
61
570
1.11
0.23
13.1
7.7
1.1
1.2
inr
—
10
162
11
88
1.27
0.23
1.8
6.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
11
89
1.25
0.21
1.6
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
18.6
—
0
12
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
222.0
—
0
8
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
68
717
0.91
0.20
3.9
5.3
0.2
0.2
e9/l
0.08
62
626
62
585
1.10
0.19
2.2
2.6
114.9
90.8
ug/l
0.57
57
534
108
1046
1.10
0.19
4.5
4.4
15.6
13.0
mm/h
0.96
99
949
13
110
1.20
0.18
1.8
5.1
1.2
1.4
mmol/l
0.57
13
105
5
66
0.75
0.17
2.6
5.4
24.6
25.8
mmol/l
—
5
66
16
176
0.90
0.10
1.4
1.3
—
—
—
0
0
9
86
1.05
0.07
2.1
2.3
—
—
—
0
0
10
111
0.89
0.06
1.1
1.6
—
—
—
0
0
13
120
1.09
0.05
2.6
3.8
1.7
1.1
%
—
6
31
98
992
0.97
0.04
4.2
4.7
—
—
—
0
0
11
119
0.92
0.04
1.5
3.3
—
—
—
0
0
68
690
0.97
0.02
3.9
5.1
0.0
0.0
e9/l
0.79
61
593
13
138
0.94
0.02
2.2
3.7
—
—
—
0
0
68
688
0.98
0.01
3.9
5.1
0.5
0.6
e9/l
0.79
61
590
12
126
0.95
0.00
2.3
2.0
402.7
373.5
nmol/l
0.48
12
119
27
275
0.98
0.00
1.3
1.3
34.3
41.9
iu/ml
—
9
90
18
175
1.03
0.00
1.4
1.3
—
—
—
0
0
70
701
1.00
0.00
3.9
5.1
1.7
1.9
e9/l
0.73
64
618
5
55
0.91
0.00
2.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.5
—
0
5
0
8
0.00
0.00
0.0
1.9
—
14.5
—
0
8
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
3.5
—
47.3
—
0
6
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
3.4
—
—
—
0
0
0
6
0.00
0.00
0.0
22.5
—
77.7
—
0
6
0
5
0.00
0.00
0.0
8.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
7
72
0.97
0.00
2.1
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
10.2
—
0
8
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
6.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
1.8
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_ENDOMETRIUM – Carcinoma in situ of endometrium

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).