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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart CD2_INSITU_GENITAL_EXALLC for full statistics.

Carcinoma in situ of other and unspecified genital organs

CD2_INSITU_GENITAL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D07
  • Cause of death: ICD-10 D07

2 out of 7 registries used, show all original rules.

312

4. Check minimum number of events

None

312

5. Include endpoints

603

6. Filter based on genotype QC (FinnGen only)

603

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D00-D09
Name in latin
Carcinoma in situ organorum genitalium aliorum sive non specificatorum

Similar endpoints

List of similar endpoints to Carcinoma in situ of other and unspecified genital organs based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 603 603 -
Unadjusted period prevalence (%) 0.21 0.21 -
Median age at first event (years) 59.66 59.66 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
548
Matched controls
5478
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
ULA02
NOMESCO Finland
Kolposcopy
25.6
224.5
363
389
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
42.6
185.5
234
94
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
1053.7
164.7
153
*
D07.0
ICD-10 Finland
Carcinoma in situ: Endometrium
1855.3
150.3
139
*
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
+∞
144.3
132
*
LEB00
NOMESCO Finland
Biopsy of vagina
48.8
134.5
163
47
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
11.1
129.4
301
540
8077/2-C52.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vagina, NOS
+∞
128.3
118
*
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
+∞
114.7
106
*
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
66.7
98.0
112
21
LEB30
NOMESCO Finland
Destruction of lesion of vaginal mucosa
81.2
90.1
100
15
LFC00
NOMESCO Finland
Partial excision of vulva
932.4
83.8
80
*
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
197.9
82.7
84
5
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
10.4
76.4
164
217
N89.2
ICD-10 Finland
Severe vaginal dysplasia, not elsewhere classified
176.0
74.1
76
5
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
7.2
71.2
200
403
N89.1
ICD-10 Finland
Moderate vaginal dysplasia
144.6
61.3
64
5
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
15.2
50.7
86
66
LCD01
NOMESCO Finland
Total laparoscopic hysterectomy
12.8
48.3
89
82
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
54.3
45.8
54
11
PJA01
NOMESCO Finland
Laparoscopic sentinel node excision
45.0
43.4
53
13
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
8.9
43.3
97
129
D06BB10
ATC
imiquimod; topical
8.9
41.5
93
123
LDA10
NOMESCO Finland
Curettage of cervix uteri
7.5
38.5
96
150
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
6.1
37.2
110
217
8380/3-C54.1
ICD-O-3
Endometrioid adenocarcinoma, NOS, of endometrium
16.0
35.9
59
41
N89.0
ICD-10 Finland
Mild vaginal dysplasia
63.1
35.7
41
7
N90.0
ICD-10 Finland
Mild vulvar dysplasia
52.3
33.0
39
8
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
3.0
32.2
284
1447
B01AB10
ATC
tinzaparin; parenteral
5.4
31.6
102
221
N87.0
ICD-10 Finland
Mild cervical dysplasia
10.9
30.8
60
61
8070/2-C51.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of vulva, NOS
+∞
26.3
25
*
A63.0
ICD-10 Finland
Anogenital (venereal) warts
7.3
23.1
57
86
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
6.2
22.4
62
110
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
3.4
21.4
116
401
N85.1
ICD-10 Finland
Endometrial adenomatous hyperplasia
11.9
21.3
39
35
8077/2-C53.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of cervix uteri
11.6
21.0
39
36
8071/2-C51.9
ICD-O-3
Differentiated intraepithelial neoplasia of vulva, NOS
+∞
21.0
20
*
N87.2
ICD-10 Finland
Severe cervical dysplasia, not elsewhere classified
8.2
20.8
47
62
ZXC96
NOMESCO Finland
Robot assisted procedure
10.9
18.4
35
34
D07AD01
ATC
clobetasol; topical
2.7
17.6
135
583
D07.2
ICD-10 Finland
Carcinoma in situ: Vagina
+∞
16.7
16
*
C51.01
ICD-10 Finland
Squamous cell carcinoma of the labium majus
+∞
16.7
16
*
LEB10
NOMESCO Finland
Excision of lesion of vagina
23.9
16.6
23
10
N90.3
ICD-10 Finland
Dysplasia of vulva, unspecified
+∞
15.7
15
*
D07.3
ICD-10 Finland
Carcinoma in situ: Other and unspecified female genital organs
+∞
15.7
15
*
8070/3-C51.9
ICD-O-3
Squamous cell carcinoma, NOS, of vulva, NOS
164.5
15.6
16
*
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
13.6
15.3
26
20
N87.1
ICD-10 Finland
Moderate cervical dysplasia
6.9
14.9
37
57
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
11.3
14.6
27
25
N95.0
ICD-10 Finland
Postmenopausal bleeding
2.8
14.5
104
427
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
3.3
14.3
77
261
N90.4
ICD-10 Finland
Leukoplakia of vulva
18.1
13.9
21
12
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.8
13.2
91
364
128
Kela drug reimbursment
Cancers of female genital organs
5.9
12.6
35
63
ZX040
NOMESCO Finland
Intracavity HDR radiotherapy
25.0
12.5
17
7
C51.11
ICD-10 Finland
Squamous cell carcinoma of the labium minus
47.8
11.9
14
*
8474
FHL
Coagulation, excision, or biopsy of local change (eg, condyloma, tumor) in operating room or anesthesia
30.8
11.7
15
5
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.6
11.6
52
153
B01AB05
ATC
enoxaparin; parenteral
2.0
11.5
198
1219
LCA06
NOMESCO Finland
Biopsy of endometrium
2.3
11.5
123
621
2333B
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Other and unspecified female genital organs[CARCINOMA IN SITU VULVAE]
+∞
11.5
11
*
ZXC10
NOMESCO Finland
Use of laser
6.5
11.1
28
45
N76.6
ICD-10 Finland
Ulceration of vulva
9.1
10.9
22
25
C51.81
ICD-10 Finland
Squamous cell carcinoma of the vulva
112.1
10.5
11
*
8542/3-C51.9
ICD-O-3
Paget disease, extramammary of vulva, NOS
+∞
10.4
10
*
N90.8
ICD-10 Finland
Other specified noninflammatory disorders of vulva and perineum
7.6
9.8
22
30
SPAT1312
SPAT
General health counselling
1.9
9.7
196
1261
N90.9
ICD-10 Finland
Noninflammatory disorder of vulva and perineum, unspecified
13.7
9.7
16
12
8070/3-C52.9
ICD-O-3
Squamous cell carcinoma, NOS, of vagina, NOS
+∞
9.4
9
*
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
9.8
9.3
18
19
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
3.6
9.2
40
116
N84.0
ICD-10 Finland
Polyp of corpus uteri
2.4
9.2
79
357
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.8
9.2
205
1362
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.0
9.1
28
58
C54.10
ICD-10 Finland
Malignant tumor of endometrium without histology
24.5
8.9
12
5
LDB20
NOMESCO Finland
Electrocoagulation or laser therapy of cervix uteri
8.1
8.4
18
23
C51.9
ICD-10 Finland
Malignant neoplasm: Vulva, unspecified
+∞
8.4
8
*
LFD10
NOMESCO Finland
Vulvectomy and excision of regional lymph nodes
+∞
8.4
8
*
E000001
ATC
NA
1.9
8.1
128
748
N85.0
ICD-10 Finland
Endometrial glandular hyperplasia
4.3
7.9
28
68
JN4AD
NOMESCO Finland
Body CT examination
2.8
7.8
50
191
WF003
NOMESCO Finland
Adjuvant radiotherapy
3.3
7.7
38
122
WF090
NOMESCO Finland
Profylactic radiotherapy
45.6
7.7
9
*
LCB25
NOMESCO Finland
Hysteroscopic excision of lesion
2.7
7.7
52
204
8380/3-C54.9
ICD-O-3
Endometrioid adenocarcinoma, NOS, of corpus uteri
8.2
7.6
16
20
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
7.6
227
1623
P01AB01
ATC
metronidazole; oral, rectal
1.7
7.5
257
1905
C52.91
ICD-10 Finland
Squamous cell carcinoma of the vagina
+∞
7.3
7
*
LFD00
NOMESCO Finland
Vulvectomy
+∞
7.3
7
*
J01DB01
ATC
cefalexin; oral
1.8
7.3
449
3910
LWA00
NOMESCO Finland
Repair of wound dehiscence in gynaecological surgery
30.4
7.2
9
*
XX3DW
NOMESCO Finland
Time consuming IT work
2.2
7.2
73
357
LFE10
NOMESCO Finland
Plastic repair of vulva
20.3
7.2
10
5
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
5.1
6.9
20
40
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.0
6.8
89
484
SPAT1153
SPAT
Removal of sutures
1.7
6.8
182
1251
PJD55
NOMESCO Finland
Block dissection of inguinal lymph nodes
40.6
6.8
8
*
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
2.4
6.7
55
241
JN4BD
NOMESCO Finland
Extensive body CT
2.2
6.7
67
324
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.7
6.6
166
1118
D06BB04
ATC
podophyllotoxin; topical
2.9
6.6
38
136
UJF32
NOMESCO Finland
Coloscopy
1.7
6.6
152
1000
LCD11
NOMESCO Finland
Laparoscopically assisted vaginal hysterectomy
5.1
6.5
19
38
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.0
6.5
24
62
J02AC01
ATC
fluconazole; systemic
1.6
6.5
289
2264
8070/2-C53.9
ICD-O-3
Squamous cell carcinoma in situ, NOS, of cervix uteri
9.4
6.3
12
13
C03CA01
ATC
furosemide; systemic
1.7
6.2
137
886
R87.7
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal histological findings
10.2
6.1
11
11
LCA13
NOMESCO Finland
Curettage of cervix and body of uterus
2.2
6.0
59
285

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_GENITAL – Carcinoma in situ of other and unspecified genital organs

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).