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Femoral hernia, bilateral

MESH Endpoint Browser PheWeb

FEMHER_BILATERAL

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

114

4. Check minimum number of events

None

114

5. Include endpoints

None

114

6. Filter based on genotype QC (FinnGen only)

110

Control definitions (FinnGen only)

Control exclude
K11_HERNIA

Extra metadata

First used in FinnGen datafreeze
DF3

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 879 487 390
Only index persons 757 427 330
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.02 0.01
Median age at first event (years)
Whole population 64.25 66.06 61.96
Only index persons 62.17 63.86 59.99

-FinnGen-

Key figures

All Female Male
Number of individuals 110 68 42
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 60.76 60.78 60.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
114
Matched controls
1140
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K41.2
ICD-10 Finland
Bilateral femoral hernia, without obstruction or gangrene
+∞
66.2
57
*
K41.0
ICD-10 Finland
Bilateral femoral hernia, with obstruction, without gangrene
+∞
53.4
47
*
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
227.0
44.3
43
*
JAB30
NOMESCO Finland
Repair of inguinal hernia using prosthetic material
+∞
29.4
27
*
K40.2
ICD-10 Finland
Bilateral inguinal hernia, without obstruction or gangrene
284.9
23.5
23
*
JAB11
NOMESCO Finland
Laparoscopic repair of inguinal hernia
+∞
20.4
19
*
K41.9
ICD-10 Finland
Unilateral or unspecified femoral hernia, without obstruction or gangrene
+∞
13.8
13
*
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
78.9
12.9
14
*
JAC11
NOMESCO Finland
Laparoscopic repair of femoral hernia
+∞
11.7
11
*
K41.1
ICD-10 Finland
Bilateral femoral hernia, with gangrene
+∞
11.7
11
*
K41.3
ICD-10 Finland
Unilateral or unspecified femoral hernia, with obstruction, without gangrene
+∞
11.7
11
*
JAB10
NOMESCO Finland
Repair of inguinal hernia
+∞
10.6
10
*
K40.3
ICD-10 Finland
Unilateral or unspecified inguinal hernia, with obstruction, without gangrene
108.7
9.6
10
*
JAC10
NOMESCO Finland
Repair of femoral hernia
+∞
8.4
8
*
A06AD11
ATC
lactulose; oral
3.7
8.1
32
110
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
20.1
7.8
11
6
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.0
7.8
52
246
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
21.7
7.3
10
5
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
3.1
6.5
34
138
JAB12
NOMESCO Finland
Laparoscopic repair of inguinal hernia, TEP
+∞
6.3
6
*
JAC30
NOMESCO Finland
Repair of femoral hernia using prosthetic material
+∞
6.3
6
*
J01MA02
ATC
ciprofloxacin; systemic
2.7
6.2
57
311

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
46
258
2.31
4.37
3.0
2.1
—
—
—
0
0
7
8
9.22
3.83
1.3
1.3
—
—
—
0
0
56
368
2.03
3.37
1.9
1.9
98.62
96.00
pmol/l
0.15
38
165
87
672
2.24
3.36
4.1
4.1
14.86
15.00
pmol/l
0.16
80
594
45
280
2.00
3.10
3.9
3.0
19.29
50.69
e6/l
1.01
35
215
42
256
2.01
3.05
4.1
2.7
—
—
—
0
0
42
262
1.95
2.83
3.9
2.9
0.25
0.45
e6/l
0.76
32
197
63
452
1.88
2.76
6.6
5.8
1.99
1.75
e9/l
0.79
53
403
49
325
1.89
2.73
4.4
3.6
57.87
79.87
e6/l
0.24
37
235
87
699
2.03
2.65
7.4
7.8
70.81
81.03
u/l
2.79
80
647
12
44
2.93
2.64
1.7
2.4
—
—
—
0
0
61
440
1.83
2.57
6.7
5.8
0.61
0.58
e9/l
0.40
49
385
63
459
1.83
2.57
6.8
5.9
0.18
0.18
e9/l
0.02
55
400
61
441
1.82
2.54
6.7
5.8
0.04
0.04
e9/l
0.12
50
385
78
614
1.86
2.40
4.8
4.2
—
—
—
0
0
36
226
1.87
2.32
5.3
4.3
—
—
—
0
0
27
155
1.97
2.26
1.3
1.3
20.02
43.43
iu/ml
1.26
13
60
96
819
2.09
2.19
5.3
4.8
1.89
1.94
mu/l
0.14
86
726
58
427
1.73
2.17
9.0
11.4
1.16
1.33
inr
1.11
16
143
58
427
1.73
2.17
8.4
5.1
1.21
1.22
mmol/l
0.19
51
384
45
314
1.72
2.00
3.3
2.9
—
—
—
0
0
43
297
1.72
1.98
6.0
4.0
7.39
7.40
ph
—
9
59
31
195
1.81
1.96
2.0
1.8
0.81
1.16
mg/l
1.16
23
162
21
116
1.99
1.95
1.5
1.2
—
—
—
0
0
36
238
1.75
1.93
6.2
8.1
—
—
—
0
0
15
73
2.21
1.91
1.5
1.5
—
—
—
0
0
8
28
2.99
1.90
7.9
3.9
—
—
—
0
0
55
410
1.66
1.89
6.7
6.5
—
—
—
0
0
20
110
1.99
1.88
1.7
1.3
—
—
—
0
0
27
165
1.83
1.87
3.2
3.6
108.37
125.74
ng/l
0.06
22
133
67
531
1.63
1.77
9.0
9.8
4.15
4.09
e9/l
0.08
60
464
99
874
2.01
1.75
22.7
14.7
26.95
22.51
mg/l
0.62
86
678
30
195
1.73
1.69
5.0
3.8
—
—
—
0
0
57
438
1.60
1.68
6.7
5.9
26.91
26.74
%
0.04
50
407
55
425
1.57
1.55
6.8
5.6
2.44
2.68
%
0.42
49
393
16
87
1.98
1.55
3.3
1.6
—
—
—
0
0
6
21
2.96
1.52
1.2
1.2
—
—
—
0
0
28
184
1.69
1.51
2.0
1.8
934.74
1253.49
nmol/l
0.92
23
131
23
143
1.76
1.50
3.5
2.8
1.67
2.09
e6/l
0.13
12
75
102
925
1.98
1.42
21.4
13.1
—
—
—
0
0
53
413
1.53
1.41
6.8
5.6
0.65
0.68
%
0.15
47
378
55
434
1.52
1.37
6.7
5.7
57.46
58.28
%
0.16
49
403
76
646
1.53
1.30
4.1
3.9
—
—
—
0
0
5
18
2.86
1.30
5.6
3.4
—
—
—
0
0
27
184
1.61
1.26
1.9
3.4
2.48
2.47
mmol/l
0.13
21
156
54
430
1.49
1.26
7.2
6.0
8.76
8.67
%
0.07
48
399
33
237
1.55
1.24
2.1
2.6
15462.75
8397.15
umol/l
0.18
28
201
10
51
2.05
1.15
12.4
8.1
94.64
94.18
%
—
10
51
47
373
1.44
1.08
5.7
4.1
102.26
39.64
ng/l
0.45
36
271
58
480
1.42
1.05
8.8
5.4
1.22
1.22
mmol/l
0.00
46
402
101
934
1.71
1.01
24.8
17.1
85.54
77.66
umol/l
0.84
101
934
10
54
1.93
1.00
12.4
7.7
0.71
0.67
%
—
10
54
10
54
1.93
1.00
12.4
7.2
1.64
1.34
%
—
10
54
23
317
0.66
0.99
2.5
3.1
—
—
—
0
0
19
126
1.61
0.99
3.1
1.9
—
—
—
0
0
91
824
1.52
0.98
3.9
4.0
1.21
1.24
mmol/l
0.13
86
740
9
51
1.83
0.97
1.3
1.3
—
—
—
0
0
12
70
1.80
0.97
8.8
6.8
—
—
—
0
0
9
52
1.79
0.95
1.1
1.2
—
—
—
0
0
104
974
1.77
0.92
32.9
20.8
30.46
30.36
pg
0.25
104
957
104
974
1.77
0.92
33.0
20.8
92.04
91.45
fl
0.63
104
957
104
975
1.76
0.90
33.5
20.9
131.10
133.72
g/l
0.97
104
957
11
64
1.80
0.90
3.3
2.3
—
—
—
0
0
93
852
1.50
0.88
4.3
4.6
1.57
1.51
mmol/l
0.56
88
769
51
423
1.37
0.87
9.9
10.0
0.00
0.00
e9/l
-0.00
38
354
8
48
1.72
0.80
3.5
2.5
1.98
1.19
%
—
8
48
6
33
1.86
0.80
3.0
1.7
—
—
—
0
0
0
25
0.00
0.80
0.0
1.6
—
—
—
0
0
96
891
1.49
0.78
4.9
5.0
2.70
2.75
mmol/l
0.23
90
804
9
53
1.76
0.77
1.1
1.3
—
—
—
0
0
5
23
2.23
0.77
1.8
2.6
—
—
—
0
0
5
25
2.04
0.73
6.0
8.0
—
—
—
0
0
89
821
1.38
0.69
5.4
6.0
40.36
40.25
mmol/mol
0.03
81
751
35
284
1.34
0.67
2.0
2.2
129.40
231.17
u/l
0.75
35
266
5
28
1.82
0.67
1.4
2.6
—
—
—
0
0
5
30
1.70
0.62
18.0
3.5
3.84
3.88
mmol/l
—
5
30
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
6
35
1.75
0.58
1.2
1.2
—
—
—
0
0
28
224
1.33
0.58
1.6
1.4
—
—
—
0
0
16
116
1.44
0.58
14.6
5.8
103.81
103.38
mmol/l
0.12
16
116
92
865
1.33
0.53
4.5
4.5
5.94
5.97
mmol/l
0.05
87
776
30
247
1.29
0.51
2.2
2.9
44.64
56.73
mg/l
0.17
19
144
22
273
0.76
0.50
3.5
3.5
—
—
—
0
0
7
45
1.59
0.50
3.6
2.6
0.41
0.66
%
—
7
45
31
259
1.27
0.47
5.5
4.1
0.00
0.00
estimate
—
9
93
51
453
1.23
0.46
5.3
3.8
0.00
0.01
estimate
0.50
12
103
8
57
1.43
0.43
1.5
1.3
—
—
—
0
0
38
329
1.23
0.43
2.5
3.3
2.33
2.37
mmol/l
0.74
32
279
5
32
1.59
0.43
21.6
4.8
—
—
—
0
0
11
79
1.43
0.42
3.5
3.7
—
—
—
0
0
8
59
1.38
0.42
1.5
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.49
0.41
1.2
1.2
—
—
—
0
0
5
34
1.49
0.41
17.6
3.2
1.19
1.33
mmol/l
—
5
34
5
35
1.45
0.40
4.0
2.5
—
—
—
0
0
9
68
1.35
0.39
1.7
2.1
—
—
—
0
0
51
462
1.19
0.36
4.9
3.8
0.00
0.00
estimate
—
10
90
13
100
1.34
0.35
1.7
1.5
—
—
—
0
0
31
269
1.21
0.34
2.5
3.5
12.75
9.00
mg/mmol
0.20
20
150
30
260
1.21
0.33
2.1
2.8
6.57
7.24
mmol/l
0.30
25
204
7
53
1.34
0.31
3.6
2.9
126.86
129.30
g/l
—
7
53
7
53
1.34
0.31
6.4
4.1
26.14
24.72
mmol/l
—
7
53
41
369
1.17
0.30
1.8
2.0
—
—
—
0
0
8
62
1.31
0.29
12.3
3.6
—
—
—
0
0
14
115
1.25
0.25
2.1
1.5
—
—
—
0
0
13
106
1.26
0.24
10.3
5.7
5.31
5.14
kpa
0.28
13
98
13
106
1.26
0.24
10.3
5.7
13.19
11.54
kpa
0.47
13
99
28
250
1.16
0.22
4.4
4.8
2.38
2.18
ug/l
0.13
23
220
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
3.2
—
32.50
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
2.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
49
460
1.11
0.18
6.6
5.1
0.00
0.00
estimate
-0.00
11
95
21
186
1.16
0.18
1.4
1.4
2.38
2.81
g/l
0.72
11
107
10
82
1.24
0.17
4.7
3.2
—
—
—
0
0
5
68
0.72
0.17
1.0
1.1
—
—
—
0
0
8
71
1.14
0.16
6.1
4.1
—
—
—
0
0
11
93
1.20
0.15
1.5
1.4
—
—
—
0
0
5
44
1.14
0.10
5.0
3.3
24.88
25.08
mmol/l
—
5
44
5
47
1.07
0.09
3.4
2.9
0.40
0.12
e6/l
—
5
47
8
74
1.09
0.07
1.6
2.3
11.27
10.11
g/l
—
8
69
28
274
1.03
0.00
5.4
3.7
—
—
—
0
0
12
117
1.03
0.00
1.3
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
305.13
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
22.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
128.78
—
0
5
0
5
0.00
0.00
0.0
1.8
—
7.38
—
0
5
0
8
0.00
0.00
0.0
2.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
31.89
—
0
8
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
111.40
—
0
5
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
9
90
1.00
-0.00
2.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
90
1.00
-0.00
1.1
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.9
—
59.86
—
0
7
0
9
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
34.33
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint FEMHER_BILATERAL and mortality.

Females

Parameter HR [95% CI] p-value
FEMHER_BILATERAL 1.462 [1.18, 1.81] < 0.001
Birth year 1.0 [0.99, 1.01] 0.999

During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 427 females with FEMHER_BILATERAL died.

Males

Parameter HR [95% CI] p-value
FEMHER_BILATERAL 1.338 [1.05, 1.71] 0.021
Birth year 0.989 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 126 out of 348 males with FEMHER_BILATERAL died.

Mortality risk

Mortality risk for people of age

years, who have FEMHER_BILATERAL.

N-year risk Females Males
1 0.167% 0.245%
5 0.996% 1.493%
10 2.343% 3.873%
15 4.664% 7.459%
20 7.967% 12.692%

Relationships between endpoints

↥

Index endpoint: FEMHER_BILATERAL – Femoral hernia, bilateral

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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