No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1709 |
4. Check minimum number of eventsNone |
1709 |
5. Include endpointsNone |
1709 |
6. Filter based on genotype QC (FinnGen only) |
1709 |
Control definitions (FinnGen only)
- Control exclude
- K11_HERNIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K40-K46
- Name in latin
- Hernia femoralis
Femoral hernia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16909 | 10051 | 6717 |
| Only index persons | 13103 | 7980 | 5123 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.29 | 0.19 |
| Only index persons | 0.26 | 0.29 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 57.75 | 58.94 | 55.78 |
| Only index persons | 54.00 | 54.97 | 52.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1709 | 945 | 764 |
| Unadjusted period prevalence (%) | 0.33 | 0.32 | 0.34 |
| Median age at first event (years) | 52.87 | 50.92 | 55.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1532
- Matched controls
- 15319
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K41.9
ICD-10 Finland
Unilateral or unspecified femoral hernia, without obstruction or gangrene
+∞
323.0
641
*
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
185.6
323.0
542
45
6123
FHL
Radical surgery
1188.9
323.0
364
*
5530A
ICD-9 Finland
Other hernia of abdominal cavity without mention of obstruction or gangrene, Femoral hernia
+∞
323.0
396
*
JAB30
NOMESCO Finland
Repair of inguinal hernia using prosthetic material
698.3
323.0
331
6
K41.3
ICD-10 Finland
Unilateral or unspecified femoral hernia, with obstruction, without gangrene
+∞
239.0
223
*
55100
ICD-8 Finland
Other hernia of abdominal cavity without mention of obstruction, Femoral
+∞
165.7
156
*
JAC10
NOMESCO Finland
Repair of femoral hernia
1622.9
151.7
145
*
JAC30
NOMESCO Finland
Repair of femoral hernia using prosthetic material
+∞
144.1
136
*
JAB11
NOMESCO Finland
Laparoscopic repair of inguinal hernia
256.5
138.5
140
6
K40.3
ICD-10 Finland
Unilateral or unspecified inguinal hernia, with obstruction, without gangrene
1194.4
115.2
111
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
39.3
94.6
120
33
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
67.5
93.0
107
17
6124
FHL
Radical cutting and plastic with foreign material
841.8
82.3
80
*
55099
ICD-8 Finland
Inguinal hernia without mention of obstruction
+∞
82.0
78
*
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
70.6
81.4
93
14
JAC11
NOMESCO Finland
Laparoscopic repair of femoral hernia
+∞
69.3
66
*
K40.2
ICD-10 Finland
Bilateral inguinal hernia, without obstruction or gangrene
127.6
68.5
73
6
JAB10
NOMESCO Finland
Repair of inguinal hernia
226.0
63.6
65
*
5509B
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,LATERALIS (SCROT]
+∞
52.4
50
*
K41.2
ICD-10 Finland
Bilateral femoral hernia, without obstruction or gangrene
+∞
50.3
48
*
K41.4
ICD-10 Finland
Unilateral or unspecified femoral hernia, with gangrene
+∞
47.1
45
*
D89
ICPC
Inguinal hernia
51.8
46.1
55
11
K41.0
ICD-10 Finland
Bilateral femoral hernia, with obstruction, without gangrene
+∞
44.0
42
*
5509A
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,MEDIALIS]
+∞
42.9
41
*
5510A
ICD-9 Finland
Other hernia of abdominal cavity, with gangrene, Femoral hernia with gangrene
+∞
42.9
41
*
JAB12
NOMESCO Finland
Laparoscopic repair of inguinal hernia, TEP
+∞
42.9
41
*
JAF10
NOMESCO Finland
Repair of umbilical hernia
38.4
41.2
52
14
6129
FHL
Other measure in this category
+∞
40.8
39
*
K40
ICD-10 Finland
Inguinal hernia
21.1
34.5
51
25
JAF30
NOMESCO Finland
Repair of umbilical hernia using prosthetic material
89.5
31.8
35
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.3
31.1
327
1596
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
47.3
30.7
37
8
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
29.6
537
3305
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
9.6
29.5
61
66
JAC12
NOMESCO Finland
Laparoscopic repair of femoral hernia, TEP
+∞
29.3
28
*
K42.0
ICD-10 Finland
Umbilical hernia with obstruction, without gangrene
254.1
24.7
25
*
6125
FHL
Residual surgery, can be reported as a side effect
+∞
23.0
22
*
JAD11
NOMESCO Finland
Laparoscopic repair of incisional hernia
223.0
21.6
22
*
K43.0
ICD-10 Finland
Incisional hernia with obstruction, without gangrene
+∞
20.9
20
*
N02BE01
ATC
paracetamol; systemic, rectal
1.9
20.0
1273
11104
5531A
ICD-9 Finland
Other hernia of abdominal cavity without mention of obstruction or gangrene, Umbilical hernia
+∞
19.8
19
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
19.2
419
2665
K41
ICD-10 Finland
Femoral hernia
192.2
18.6
19
*
JFB00
NOMESCO Finland
Partial resection of small intestine
6.7
18.5
47
72
ZXA00
NOMESCO Finland
Right side
1.7
16.3
422
2803
JAD10
NOMESCO Finland
Repair of incisional hernia
48.0
16.0
19
*
N02AX02
ATC
tramadol; systemic, rectal
1.6
15.9
616
4554
R03AC02
ATC
salbutamol; inhalant
1.6
15.4
702
5392
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
14.7
310
1931
K40.4
ICD-10 Finland
Unilateral or unspecified inguinal hernia, with gangrene
+∞
14.6
14
*
5509D
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,RECIDIVANS]
+∞
14.6
14
*
ZXA05
NOMESCO Finland
Left side
1.7
14.3
385
2575
UJF32
NOMESCO Finland
Coloscopy
1.7
14.1
373
2479
JAH01
NOMESCO Finland
Laparoscopy
3.4
13.9
67
203
WX320
NOMESCO Finland
Spinalanesthesy
1.7
13.6
332
2153
5509X
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,ALIA SEU NUD]
+∞
13.6
13
*
JAB96
NOMESCO Finland
Other repair of inguinal hernia
+∞
13.6
13
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
13.1
372
2515
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.1
12.8
157
805
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
12.7
626
4822
M79.6
ICD-10 Finland
Pain in limb
1.5
12.7
487
3542
JAC96
NOMESCO Finland
Other repair of femoral hernia
+∞
12.5
12
*
S18
ICPC
Laceration/cut
1.5
12.5
582
4424
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
12.4
382
2628
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
12.3
619
4778
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
12.3
268
1677
SPAT1263
SPAT
Sampling
1.5
12.2
599
4597
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
12.1
280
1785
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
12.0
250
1546
JN3AD
NOMESCO Finland
Abdominal CT examination
2.3
11.6
110
501
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
11.6
422
3021
JAB97
NOMESCO Finland
Other laparoscopic repair of inguinal hernia
+∞
11.5
11
*
JAF11
NOMESCO Finland
Laparoscopic repair of umbilical hernia
120.9
11.4
12
*
SPAT1153
SPAT
Removal of sutures
1.5
11.3
456
3338
A02BC01
ATC
omeprazole; systemic
1.5
11.3
403
2870
B01AB05
ATC
enoxaparin; parenteral
1.5
11.2
441
3208
J45.1
ICD-10 Finland
Nonallergic asthma
2.3
11.0
106
487
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.2
11.0
114
544
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.7
11.0
255
1624
K45.8
ICD-10 Finland
Other specified abdominal hernia without obstruction or gangrene
43.6
10.9
13
*
A02BC02
ATC
pantoprazole; systemic
1.4
10.7
906
7682
A02BC03
ATC
lansoprazole; oral
1.5
10.7
409
2953
J01AA02
ATC
doxycycline; systemic
1.5
10.6
1100
9702
55110
ICD-8 Finland
Other hernia of abdominal cavity without mention of obstruction, Umbilical
+∞
10.4
10
*
JAB91
NOMESCO Finland
Repair of recurrent inguinal hernia, endoscopy
+∞
10.4
10
*
WX704
NOMESCO Finland
Intubation
2.2
10.3
102
476
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.9
10.2
148
807
N03AX12
ATC
gabapentin; oral
1.7
10.2
216
1337
A02BC05
ATC
esomeprazole; systemic
1.5
10.2
533
4108
G04CA02
ATC
tamsulosin; oral
1.6
10.0
327
2270
M54.5
ICD-10 Finland
Low back pain
1.5
10.0
418
3070
SPAT1301
SPAT
No procedures
1.5
9.9
449
3357
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
9.8
144
789
J01CA04
ATC
amoxicillin; systemic
1.4
9.6
1079
9551
D91
ICPC
Abdominal hernia other
15.1
9.5
15
10
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
9.5
533
4149
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
9.4
209
1308
J01MA02
ATC
ciprofloxacin; systemic
1.4
9.4
548
4290
J01DA01
ATC
[U] cefalexin; systemic
1.4
9.4
863
7341
6122
FHL
Removal of the hernia bag without plastic
+∞
9.4
9
*
JAE10
NOMESCO Finland
Repair of epigastric hernia
+∞
9.4
9
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.7
9.3
194
1193
R51.80
ICD-10 Finland
Headache
1.8
9.3
174
1038
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
9.2
126
676
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
9.0
235
1540
J01DB01
ATC
cefalexin; oral
1.4
8.9
1118
10013
M54.4
ICD-10 Finland
Lumbago with sciatica
1.7
8.8
208
1328
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
8.8
252
1689
R03BA05
ATC
fluticasone; inhalant
1.6
8.8
233
1532
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
8.6
565
4504
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
1.8
8.6
146
843
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
8.6
470
3629
WX110
NOMESCO Finland
Local anesthesy
1.4
8.5
863
7407
K46.9
ICD-10 Finland
Unspecified abdominal hernia without obstruction or gangrene
27.7
8.5
11
*
K59.09
ICD-10 Finland
Constipation, unspecified
2.1
8.5
91
441
PHD99
NOMESCO Finland
Resection of other vein
2.1
8.4
95
472
K41.1
ICD-10 Finland
Bilateral femoral hernia, with gangrene
+∞
8.3
8
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.2
8.3
85
402
M19.0
ICD-10 Finland
Primary arthrosis of other joints
1.8
8.3
132
745
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
8.0
273
1904
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
2.1
7.9
92
462
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.5
7.9
303
2172
WX402
NOMESCO Finland
General anaesthesia
1.6
7.9
200
1298
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.7
7.8
150
901
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
7.7
182
1161
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
5.3
7.7
22
42
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.5
7.7
291
2076
H02AB06
ATC
prednisolone; systemic
1.4
7.7
635
5239
WX702
NOMESCO Finland
Supraglottic ventilation device
2.3
7.7
69
311
SPAT1260
SPAT
Consultation of another employee
1.5
7.7
240
1641
R06.0
ICD-10 Finland
Dyspnoea
1.5
7.6
331
2433
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.7
7.6
155
950
R96
ICPC
Asthma
1.9
7.5
113
625
ZXA10
NOMESCO Finland
Bilateral
1.5
7.5
251
1744
L17
ICPC
Foot/toe symptom/complaint
1.5
7.5
328
2414
A06AD11
ATC
lactulose; oral
1.6
7.4
215
1443
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
7.4
203
1342
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
7.4
118
669
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
7.4
332
2455
R52.2
ICD-10 Finland
Other chronic pain
2.7
7.4
48
182
JBB01
NOMESCO Finland
Laparoscopic repair of paraoesophageal hernia
+∞
7.3
7
*
5532A
ICD-9 Finland
Other hernia of abdominal cavity without mention of obstruction or gangrene, Ventral hernia [incisional][HERNIA VENTRALIS SINE OBSTRUCTIONE ET GANGRAENA]
+∞
7.3
7
*
M01AB05
ATC
diclofenac; systemic, rectal
1.3
7.2
878
7663
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.8
7.2
119
681
M02AA07
ATC
piroxicam; topical
1.4
7.1
520
4189
M01AB55
ATC
diclofenac, combinations; oral
1.9
7.1
104
571
N06AA09
ATC
amitriptyline; systemic
1.7
7.1
133
794
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
7.1
413
3203
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
7.0
331
2465
N81.6
ICD-10 Finland
Rectocele
2.0
7.0
87
450
XG410
NOMESCO Finland
Flow-volume spirometry
2.4
7.0
58
250
WX725
NOMESCO Finland
Noninvasive ventilation
2.3
6.9
61
273
XKD00
NOMESCO Finland
Uroflowmetry
1.5
6.8
217
1487
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
6.8
208
1417
UKC02
NOMESCO Finland
Cystoscopy
1.5
6.7
227
1577
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
6.7
164
1055
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
6.7
225
1562
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
1.9
6.6
94
510
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
1.9
6.6
88
466
L16
ICPC
Ankle symptom/complaint
1.8
6.6
121
715
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
3.8
6.6
26
70
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
3.8
6.6
26
70
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.5
6.6
211
1450
P01AB01
ATC
metronidazole; oral, rectal
1.4
6.6
485
3903
R42
ICD-10 Finland
Dizziness and giddiness
1.4
6.6
293
2162
R13
ICD-10 Finland
Dysphagia
1.9
6.6
88
471
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.4
6.5
344
2616
WX720
NOMESCO Finland
Own respiration
2.4
6.5
52
222
UJD02
NOMESCO Finland
Gastroscopy
2.1
6.4
70
344
SPAT1312
SPAT
General health counselling
1.4
6.4
399
3117
K43.2
ICD-10 Finland
Incisional hernia without obstruction or gangrene
70.1
6.4
7
*
A02BA02
ATC
ranitidine; systemic
1.4
6.4
279
2046
N81.1
ICD-10 Finland
Cystocele
1.9
6.3
90
491
R52.9
ICD-10 Finland
Pain, unspecified
1.8
6.3
110
643
R03AK07
ATC
formoterol and budesonide; inhalant
1.5
6.3
222
1558
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.8
6.3
101
576
JAC97
NOMESCO Finland
Other laparoscopic repair of femoral hernia
+∞
6.3
6
*
K40.0
ICD-10 Finland
Bilateral inguinal hernia, with obstruction, without gangrene
+∞
6.3
6
*
JAB93
NOMESCO Finland
Repair of recurrent inguinal hernia, implantation
+∞
6.3
6
*
D06
ICPC
Abdominal pain localized other
1.8
6.3
99
562
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
6.2
229
1623
M01AC06
ATC
meloxicam; systemic, rectal
1.3
6.2
470
3796
TPH07
NOMESCO Finland
Cathetrisation of artery
1.6
6.2
137
861
PHD76
NOMESCO Finland
Resection of long saphenous vein
2.0
6.1
70
352
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
6.1
508
4156
N05BB01
ATC
hydroxyzine; systemic
2.0
6.1
78
410
M01AX17
ATC
nimesulide; oral
1.4
6.1
327
2493
C07AB07
ATC
bisoprolol; oral
1.3
6.1
669
5697
S54
ICPC
Skin, Repair/fix-suture/cast/prosth device
2.5
6.1
43
172
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.7
6.0
116
699
J02AC01
ATC
fluconazole; systemic
1.3
6.0
463
3744
Mortality – FinRegistry
↥Association
Association between endpoint K11_FEMHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_FEMHER | 1.32 [1.19, 1.47] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.14 |
During the follow-up period (1.1.1998 — 31.12.2019), 1345 out of 4553 females with K11_FEMHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_FEMHER | 1.088 [0.97, 1.22] | 0.154 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 907 out of 3097 males with K11_FEMHER died.
Mortality risk
Mortality risk for people of age
years, who have K11_FEMHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.138% | 0.184% |
| 5 | 0.714% | 1.181% |
| 10 | 1.955% | 3.021% |
| 15 | 3.699% | 5.616% |
| 20 | 6.236% | 9.907% |
Relationships between endpoints
↥Index endpoint: K11_FEMHER – Femoral hernia
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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