Femoral hernia

K11_FEMHER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K41
  • Hospital discharge: ICD-9 5510|552A|5530
  • Hospital discharge: ICD-8 5510
  • Cause of death: ICD-10 K41
  • Cause of death: ICD-9 5510|552A|5530
  • Cause of death: ICD-8 5510

2 out of 7 registries used, show all original rules.

1709

4. Check minimum number of events

None

1709

5. Include endpoints

None

1709

6. Filter based on genotype QC (FinnGen only)

1709

Control definitions (FinnGen only)

Control exclude
K11_HERNIA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K40-K46
Name in latin
Hernia femoralis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 16909 10051 6717
Only index persons 13103 7980 5123
Unadjusted period prevalence (%)
Whole population 0.25 0.29 0.19
Only index persons 0.26 0.29 0.20
Median age at first event (years)
Whole population 57.75 58.94 55.78
Only index persons 54.00 54.97 52.48

-FinnGen-

Key figures

All Female Male
Number of individuals 1709 945 764
Unadjusted period prevalence (%) 0.33 0.32 0.34
Median age at first event (years) 52.87 50.92 55.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1532
Matched controls
15319
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K41.9
ICD-10 Finland
Unilateral or unspecified femoral hernia, without obstruction or gangrene
+∞
323.0
641
*
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
185.6
323.0
542
45
6123
FHL
Radical surgery
1188.9
323.0
364
*
5530A
ICD-9 Finland
Other hernia of abdominal cavity without mention of obstruction or gangrene, Femoral hernia
+∞
323.0
396
*
JAB30
NOMESCO Finland
Repair of inguinal hernia using prosthetic material
698.3
323.0
331
6
K41.3
ICD-10 Finland
Unilateral or unspecified femoral hernia, with obstruction, without gangrene
+∞
239.0
223
*
55100
ICD-8 Finland
Other hernia of abdominal cavity without mention of obstruction, Femoral
+∞
165.7
156
*
JAC10
NOMESCO Finland
Repair of femoral hernia
1622.9
151.7
145
*
JAC30
NOMESCO Finland
Repair of femoral hernia using prosthetic material
+∞
144.1
136
*
JAB11
NOMESCO Finland
Laparoscopic repair of inguinal hernia
256.5
138.5
140
6
K40.3
ICD-10 Finland
Unilateral or unspecified inguinal hernia, with obstruction, without gangrene
1194.4
115.2
111
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
39.3
94.6
120
33
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
67.5
93.0
107
17
6124
FHL
Radical cutting and plastic with foreign material
841.8
82.3
80
*
55099
ICD-8 Finland
Inguinal hernia without mention of obstruction
+∞
82.0
78
*
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
70.6
81.4
93
14
JAC11
NOMESCO Finland
Laparoscopic repair of femoral hernia
+∞
69.3
66
*
K40.2
ICD-10 Finland
Bilateral inguinal hernia, without obstruction or gangrene
127.6
68.5
73
6
JAB10
NOMESCO Finland
Repair of inguinal hernia
226.0
63.6
65
*
5509B
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,LATERALIS (SCROT]
+∞
52.4
50
*
K41.2
ICD-10 Finland
Bilateral femoral hernia, without obstruction or gangrene
+∞
50.3
48
*
K41.4
ICD-10 Finland
Unilateral or unspecified femoral hernia, with gangrene
+∞
47.1
45
*
D89
ICPC
Inguinal hernia
51.8
46.1
55
11
K41.0
ICD-10 Finland
Bilateral femoral hernia, with obstruction, without gangrene
+∞
44.0
42
*
5509A
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,MEDIALIS]
+∞
42.9
41
*
5510A
ICD-9 Finland
Other hernia of abdominal cavity, with gangrene, Femoral hernia with gangrene
+∞
42.9
41
*
JAB12
NOMESCO Finland
Laparoscopic repair of inguinal hernia, TEP
+∞
42.9
41
*
JAF10
NOMESCO Finland
Repair of umbilical hernia
38.4
41.2
52
14
6129
FHL
Other measure in this category
+∞
40.8
39
*
K40
ICD-10 Finland
Inguinal hernia
21.1
34.5
51
25
JAF30
NOMESCO Finland
Repair of umbilical hernia using prosthetic material
89.5
31.8
35
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.3
31.1
327
1596
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
47.3
30.7
37
8
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
29.6
537
3305
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
9.6
29.5
61
66
JAC12
NOMESCO Finland
Laparoscopic repair of femoral hernia, TEP
+∞
29.3
28
*
K42.0
ICD-10 Finland
Umbilical hernia with obstruction, without gangrene
254.1
24.7
25
*
6125
FHL
Residual surgery, can be reported as a side effect
+∞
23.0
22
*
JAD11
NOMESCO Finland
Laparoscopic repair of incisional hernia
223.0
21.6
22
*
K43.0
ICD-10 Finland
Incisional hernia with obstruction, without gangrene
+∞
20.9
20
*
N02BE01
ATC
paracetamol; systemic, rectal
1.9
20.0
1273
11104
5531A
ICD-9 Finland
Other hernia of abdominal cavity without mention of obstruction or gangrene, Umbilical hernia
+∞
19.8
19
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
19.2
419
2665
K41
ICD-10 Finland
Femoral hernia
192.2
18.6
19
*
JFB00
NOMESCO Finland
Partial resection of small intestine
6.7
18.5
47
72
ZXA00
NOMESCO Finland
Right side
1.7
16.3
422
2803
JAD10
NOMESCO Finland
Repair of incisional hernia
48.0
16.0
19
*
N02AX02
ATC
tramadol; systemic, rectal
1.6
15.9
616
4554
R03AC02
ATC
salbutamol; inhalant
1.6
15.4
702
5392
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
14.7
310
1931
K40.4
ICD-10 Finland
Unilateral or unspecified inguinal hernia, with gangrene
+∞
14.6
14
*
5509D
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,RECIDIVANS]
+∞
14.6
14
*
ZXA05
NOMESCO Finland
Left side
1.7
14.3
385
2575
UJF32
NOMESCO Finland
Coloscopy
1.7
14.1
373
2479
JAH01
NOMESCO Finland
Laparoscopy
3.4
13.9
67
203
WX320
NOMESCO Finland
Spinalanesthesy
1.7
13.6
332
2153
5509X
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,ALIA SEU NUD]
+∞
13.6
13
*
JAB96
NOMESCO Finland
Other repair of inguinal hernia
+∞
13.6
13
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
13.1
372
2515
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.1
12.8
157
805
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
12.7
626
4822
M79.6
ICD-10 Finland
Pain in limb
1.5
12.7
487
3542
JAC96
NOMESCO Finland
Other repair of femoral hernia
+∞
12.5
12
*
S18
ICPC
Laceration/cut
1.5
12.5
582
4424
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
12.4
382
2628
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
12.3
619
4778
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
12.3
268
1677
SPAT1263
SPAT
Sampling
1.5
12.2
599
4597
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
12.1
280
1785
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
12.0
250
1546
JN3AD
NOMESCO Finland
Abdominal CT examination
2.3
11.6
110
501
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
11.6
422
3021
JAB97
NOMESCO Finland
Other laparoscopic repair of inguinal hernia
+∞
11.5
11
*
JAF11
NOMESCO Finland
Laparoscopic repair of umbilical hernia
120.9
11.4
12
*
SPAT1153
SPAT
Removal of sutures
1.5
11.3
456
3338
A02BC01
ATC
omeprazole; systemic
1.5
11.3
403
2870
B01AB05
ATC
enoxaparin; parenteral
1.5
11.2
441
3208
J45.1
ICD-10 Finland
Nonallergic asthma
2.3
11.0
106
487
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.2
11.0
114
544
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.7
11.0
255
1624
K45.8
ICD-10 Finland
Other specified abdominal hernia without obstruction or gangrene
43.6
10.9
13
*
A02BC02
ATC
pantoprazole; systemic
1.4
10.7
906
7682
A02BC03
ATC
lansoprazole; oral
1.5
10.7
409
2953
J01AA02
ATC
doxycycline; systemic
1.5
10.6
1100
9702
55110
ICD-8 Finland
Other hernia of abdominal cavity without mention of obstruction, Umbilical
+∞
10.4
10
*
JAB91
NOMESCO Finland
Repair of recurrent inguinal hernia, endoscopy
+∞
10.4
10
*
WX704
NOMESCO Finland
Intubation
2.2
10.3
102
476
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.9
10.2
148
807
N03AX12
ATC
gabapentin; oral
1.7
10.2
216
1337
A02BC05
ATC
esomeprazole; systemic
1.5
10.2
533
4108
G04CA02
ATC
tamsulosin; oral
1.6
10.0
327
2270
M54.5
ICD-10 Finland
Low back pain
1.5
10.0
418
3070
SPAT1301
SPAT
No procedures
1.5
9.9
449
3357
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
9.8
144
789
J01CA04
ATC
amoxicillin; systemic
1.4
9.6
1079
9551
D91
ICPC
Abdominal hernia other
15.1
9.5
15
10
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
9.5
533
4149
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
9.4
209
1308
J01MA02
ATC
ciprofloxacin; systemic
1.4
9.4
548
4290
J01DA01
ATC
[U] cefalexin; systemic
1.4
9.4
863
7341
6122
FHL
Removal of the hernia bag without plastic
+∞
9.4
9
*
JAE10
NOMESCO Finland
Repair of epigastric hernia
+∞
9.4
9
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.7
9.3
194
1193
R51.80
ICD-10 Finland
Headache
1.8
9.3
174
1038
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
9.2
126
676
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
9.0
235
1540
J01DB01
ATC
cefalexin; oral
1.4
8.9
1118
10013
M54.4
ICD-10 Finland
Lumbago with sciatica
1.7
8.8
208
1328
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
8.8
252
1689
R03BA05
ATC
fluticasone; inhalant
1.6
8.8
233
1532
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
8.6
565
4504
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
1.8
8.6
146
843
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
8.6
470
3629
WX110
NOMESCO Finland
Local anesthesy
1.4
8.5
863
7407
K46.9
ICD-10 Finland
Unspecified abdominal hernia without obstruction or gangrene
27.7
8.5
11
*
K59.09
ICD-10 Finland
Constipation, unspecified
2.1
8.5
91
441
PHD99
NOMESCO Finland
Resection of other vein
2.1
8.4
95
472
K41.1
ICD-10 Finland
Bilateral femoral hernia, with gangrene
+∞
8.3
8
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.2
8.3
85
402
M19.0
ICD-10 Finland
Primary arthrosis of other joints
1.8
8.3
132
745
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
8.0
273
1904
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
2.1
7.9
92
462
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.5
7.9
303
2172
WX402
NOMESCO Finland
General anaesthesia
1.6
7.9
200
1298
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.7
7.8
150
901
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
7.7
182
1161
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
5.3
7.7
22
42
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.5
7.7
291
2076
H02AB06
ATC
prednisolone; systemic
1.4
7.7
635
5239
WX702
NOMESCO Finland
Supraglottic ventilation device
2.3
7.7
69
311
SPAT1260
SPAT
Consultation of another employee
1.5
7.7
240
1641
R06.0
ICD-10 Finland
Dyspnoea
1.5
7.6
331
2433
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.7
7.6
155
950
R96
ICPC
Asthma
1.9
7.5
113
625
ZXA10
NOMESCO Finland
Bilateral
1.5
7.5
251
1744
L17
ICPC
Foot/toe symptom/complaint
1.5
7.5
328
2414
A06AD11
ATC
lactulose; oral
1.6
7.4
215
1443
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
7.4
203
1342
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
7.4
118
669
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
7.4
332
2455
R52.2
ICD-10 Finland
Other chronic pain
2.7
7.4
48
182
JBB01
NOMESCO Finland
Laparoscopic repair of paraoesophageal hernia
+∞
7.3
7
*
5532A
ICD-9 Finland
Other hernia of abdominal cavity without mention of obstruction or gangrene, Ventral hernia [incisional][HERNIA VENTRALIS SINE OBSTRUCTIONE ET GANGRAENA]
+∞
7.3
7
*
M01AB05
ATC
diclofenac; systemic, rectal
1.3
7.2
878
7663
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.8
7.2
119
681
M02AA07
ATC
piroxicam; topical
1.4
7.1
520
4189
M01AB55
ATC
diclofenac, combinations; oral
1.9
7.1
104
571
N06AA09
ATC
amitriptyline; systemic
1.7
7.1
133
794
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
7.1
413
3203
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
7.0
331
2465
N81.6
ICD-10 Finland
Rectocele
2.0
7.0
87
450
XG410
NOMESCO Finland
Flow-volume spirometry
2.4
7.0
58
250
WX725
NOMESCO Finland
Noninvasive ventilation
2.3
6.9
61
273
XKD00
NOMESCO Finland
Uroflowmetry
1.5
6.8
217
1487
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
6.8
208
1417
UKC02
NOMESCO Finland
Cystoscopy
1.5
6.7
227
1577
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
6.7
164
1055
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
6.7
225
1562
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
1.9
6.6
94
510
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
1.9
6.6
88
466
L16
ICPC
Ankle symptom/complaint
1.8
6.6
121
715
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
3.8
6.6
26
70
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
3.8
6.6
26
70
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.5
6.6
211
1450
P01AB01
ATC
metronidazole; oral, rectal
1.4
6.6
485
3903
R42
ICD-10 Finland
Dizziness and giddiness
1.4
6.6
293
2162
R13
ICD-10 Finland
Dysphagia
1.9
6.6
88
471
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.4
6.5
344
2616
WX720
NOMESCO Finland
Own respiration
2.4
6.5
52
222
UJD02
NOMESCO Finland
Gastroscopy
2.1
6.4
70
344
SPAT1312
SPAT
General health counselling
1.4
6.4
399
3117
K43.2
ICD-10 Finland
Incisional hernia without obstruction or gangrene
70.1
6.4
7
*
A02BA02
ATC
ranitidine; systemic
1.4
6.4
279
2046
N81.1
ICD-10 Finland
Cystocele
1.9
6.3
90
491
R52.9
ICD-10 Finland
Pain, unspecified
1.8
6.3
110
643
R03AK07
ATC
formoterol and budesonide; inhalant
1.5
6.3
222
1558
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.8
6.3
101
576
JAC97
NOMESCO Finland
Other laparoscopic repair of femoral hernia
+∞
6.3
6
*
K40.0
ICD-10 Finland
Bilateral inguinal hernia, with obstruction, without gangrene
+∞
6.3
6
*
JAB93
NOMESCO Finland
Repair of recurrent inguinal hernia, implantation
+∞
6.3
6
*
D06
ICPC
Abdominal pain localized other
1.8
6.3
99
562
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
6.2
229
1623
M01AC06
ATC
meloxicam; systemic, rectal
1.3
6.2
470
3796
TPH07
NOMESCO Finland
Cathetrisation of artery
1.6
6.2
137
861
PHD76
NOMESCO Finland
Resection of long saphenous vein
2.0
6.1
70
352
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
6.1
508
4156
N05BB01
ATC
hydroxyzine; systemic
2.0
6.1
78
410
M01AX17
ATC
nimesulide; oral
1.4
6.1
327
2493
C07AB07
ATC
bisoprolol; oral
1.3
6.1
669
5697
S54
ICPC
Skin, Repair/fix-suture/cast/prosth device
2.5
6.1
43
172
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.7
6.0
116
699
J02AC01
ATC
fluconazole; systemic
1.3
6.0
463
3744

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
857
6312
1.72
25.97
4.5
4.1
—
—
—
0
0
583
4203
1.59
17.04
2.9
2.4
55.6
57.4
u/l
0.71
534
3852
985
8057
1.53
15.81
6.1
4.6
6.7
6.8
mmol/l
1.93
927
7565
241
1408
1.83
15.35
8.5
7.4
95.3
95.3
%
0.01
233
1353
736
5804
1.47
13.22
11.5
10.0
1.3
1.3
inr
0.05
186
1682
1153
9934
1.49
13.06
4.7
4.0
12.0
13.6
mm/h
3.57
1076
9113
218
1297
1.78
12.98
9.2
7.9
123.2
120.8
g/l
0.91
210
1243
878
7183
1.46
12.92
6.1
6.0
11.0
11.6
umol/l
1.45
826
6794
1063
9041
1.46
12.62
5.6
4.7
2088.4
1850.9
e6/l
0.07
23
159
570
4309
1.48
12.51
2.5
2.4
—
—
—
0
0
1205
10558
1.48
11.86
8.1
7.3
77.6
79.6
u/l
0.78
1131
9859
787
6384
1.43
11.68
7.1
5.7
1.2
1.2
mmol/l
0.98
703
5710
135
713
1.97
11.65
11.4
10.1
—
—
—
0
0
250
1591
1.67
11.63
8.5
7.0
5.1
5.1
kpa
0.29
240
1508
753
6065
1.43
11.60
5.2
4.5
34.9
35.1
g/l
0.45
698
5601
855
7051
1.43
11.52
7.9
6.6
1.2
1.2
mmol/l
0.41
728
5872
249
1588
1.66
11.48
8.5
7.0
1.1
1.1
mmol/l
0.02
197
1229
1448
13232
1.62
11.37
19.3
15.0
26.0
25.3
mg/l
0.32
1212
10534
249
1592
1.66
11.36
8.5
7.0
11.8
11.9
kpa
0.20
239
1511
571
4383
1.45
11.34
3.3
3.0
1591.4
1571.5
ng/l
0.04
502
3779
643
5058
1.43
11.15
4.4
3.5
—
5.6
—
0
6
689
5489
1.43
11.14
4.6
3.8
43.8
57.3
ng/l
0.47
505
4028
1075
9343
1.41
10.10
5.1
4.5
—
—
—
0
0
791
6534
1.39
10.04
4.5
3.8
0.0
0.0
estimate
0.00
137
1257
909
7713
1.38
9.66
8.7
8.8
4.3
4.2
e9/l
0.39
804
6700
465
3536
1.43
9.38
2.4
2.1
3.2
3.0
mg/l
0.50
400
2980
795
6626
1.37
9.31
4.6
3.8
0.0
0.0
estimate
0.80
139
1237
391
2886
1.46
9.23
5.6
4.1
1.0
1.0
kg/l
0.10
58
440
384
2826
1.46
9.20
1.8
1.7
1.3
1.2
mg/l
0.16
296
2183
145
851
1.77
9.00
9.8
9.0
93.9
93.7
%
0.15
145
845
253
1726
1.55
8.71
7.6
6.6
103.6
104.3
mmol/l
1.34
244
1685
783
6556
1.36
8.70
5.9
5.1
0.0
0.0
estimate
0.50
139
1264
668
5471
1.36
8.49
3.1
2.7
122.8
140.5
ug/l
0.94
614
4986
443
3394
1.41
8.43
1.6
1.6
21.3
20.9
nmol/l
0.19
373
2866
231
1558
1.56
8.35
1.7
1.7
—
—
—
0
0
244
1678
1.53
8.07
1.2
1.2
—
—
—
0
0
146
890
1.70
7.94
8.4
6.5
24.5
24.6
mmol/l
0.06
135
823
427
3281
1.40
7.92
2.3
2.3
—
—
—
0
0
794
6729
1.34
7.86
6.2
5.6
1.8
1.9
e9/l
2.08
694
5857
800
6794
1.33
7.78
6.4
5.8
0.2
0.2
e9/l
0.20
713
5895
1481
13870
1.51
7.59
22.4
17.5
139.5
139.6
mmol/l
1.28
1455
13477
153
956
1.66
7.58
5.9
4.5
—
—
—
0
0
1483
13904
1.50
7.44
22.4
17.7
4.0
4.0
mmol/l
0.05
1453
13487
359
2709
1.41
7.33
4.8
3.8
246.6
400.2
ng/l
0.87
296
2248
772
6569
1.32
7.21
6.3
5.6
0.0
0.0
e9/l
0.10
667
5620
498
3976
1.36
7.20
4.2
4.2
—
—
—
0
0
700
5882
1.32
7.13
2.1
2.0
92.8
94.0
pmol/l
0.23
349
3006
397
3080
1.38
6.83
4.9
3.6
—
—
—
0
0
766
6547
1.31
6.79
6.2
5.5
0.6
0.6
e9/l
0.43
662
5585
180
1202
1.56
6.79
7.7
6.6
1.2
1.4
mmol/l
2.35
175
1153
453
3616
1.34
6.44
5.4
4.1
0.0
0.0
estimate
0.40
129
1218
142
911
1.61
6.36
1.5
1.4
—
—
—
0
0
517
4218
1.32
6.31
4.2
3.9
7.4
7.4
ph
0.23
82
843
114
702
1.67
6.01
10.3
9.4
24.4
24.3
mmol/l
0.07
103
658
361
2814
1.36
5.94
1.9
1.8
1175.1
1186.3
nmol/l
0.08
274
2102
167
1131
1.53
5.92
9.4
7.9
—
—
—
0
0
258
1910
1.41
5.80
2.3
2.0
—
—
—
0
0
202
1433
1.46
5.71
2.8
2.6
7.8
8.5
umol/l
0.13
172
1249
80
453
1.80
5.68
7.4
5.7
1.4
1.3
mmol/l
0.08
66
388
518
4284
1.30
5.60
2.4
2.1
322.4
196.9
u/l
0.41
491
3994
724
6251
1.27
5.58
6.4
5.7
58.7
57.9
%
0.83
679
5811
1176
10780
1.29
5.52
25.8
19.6
331.5
331.8
g/l
0.72
1167
10689
166
1145
1.50
5.40
4.9
3.4
—
—
—
0
0
377
3004
1.33
5.31
2.8
2.6
5.4
5.7
e6/l
0.20
334
2642
571
4810
1.28
5.30
3.4
3.2
2.3
2.4
mmol/l
0.52
483
4143
1483
14083
1.40
5.23
12.0
10.5
23.8
25.3
u/l
2.11
1436
13497
249
1868
1.39
5.16
5.7
5.3
1.0
1.0
mmol/l
0.02
229
1719
276
2106
1.37
5.16
2.2
2.1
29.6
30.0
s
0.60
266
2043
58
307
1.92
5.11
8.4
6.8
11.3
11.2
mmol/l
0.03
50
268
58
307
1.92
5.11
8.4
6.8
104.4
105.5
mmol/l
0.87
50
268
1445
13682
1.36
5.04
18.5
14.3
—
—
—
0
0
256
1939
1.38
5.01
27.6
26.6
1.4
1.4
inr
0.05
28
277
729
6356
1.26
5.00
6.6
5.9
26.3
26.9
%
0.89
681
5889
537
4517
1.28
4.98
3.7
3.3
—
—
—
0
0
1101
10072
1.26
4.93
4.3
4.0
15.0
14.9
pmol/l
0.33
990
9037
1301
12151
1.30
4.89
5.2
4.8
1.9
2.1
mu/l
0.69
1177
10964
709
6176
1.25
4.86
6.6
5.8
2.9
2.8
%
0.26
666
5719
576
4899
1.27
4.85
3.8
3.7
96.7
126.3
e6/l
0.52
421
3535
1527
14612
1.42
4.80
27.8
22.1
6.8
6.8
e9/l
0.17
1492
14124
1526
14604
1.42
4.76
27.7
22.0
91.6
91.4
fl
0.47
1510
14340
711
6208
1.25
4.74
6.9
6.1
8.8
8.8
%
0.01
670
5777
1526
14606
1.42
4.74
27.6
22.0
30.4
30.4
pg
0.05
1509
14340
1526
14607
1.42
4.73
27.8
22.1
4.4
4.4
e12/l
1.27
1490
14121
19
63
3.04
4.67
3.2
2.0
0.2
0.2
e9/l
0.16
19
55
1526
14612
1.41
4.67
27.9
22.2
132.9
133.7
g/l
1.21
1512
14351
1525
14601
1.41
4.67
27.8
22.1
245.0
247.4
e9/l
0.75
1493
14174
89
553
1.64
4.59
5.9
4.4
—
—
—
0
0
177
1277
1.43
4.59
3.8
2.9
188.5
220.6
ng/l
0.70
157
1174
688
6002
1.24
4.58
6.5
5.8
0.7
0.7
%
0.24
644
5565
19
64
2.99
4.56
3.2
2.0
358.8
566.9
e6/l
0.79
19
55
325
2590
1.31
4.52
1.3
1.2
1.7
1.6
u/ml
0.06
78
676
111
731
1.55
4.51
2.3
2.4
—
—
—
0
0
462
3867
1.27
4.37
3.3
3.1
0.4
0.5
e6/l
0.15
349
2953
502
4244
1.26
4.37
3.3
3.2
40.9
92.6
e6/l
1.69
391
3285
201
1498
1.39
4.34
3.6
4.0
26.5
18.7
ug/l
0.17
164
1242
14
40
3.52
4.33
5.5
7.5
25.2
25.2
mmol/l
0.02
14
35
92
586
1.60
4.32
6.5
4.9
0.9
0.9
%
0.29
84
545
406
3356
1.28
4.25
6.3
6.4
—
—
—
0
0
1375
13009
1.29
4.20
4.9
4.7
5.9
6.0
mmol/l
2.19
1249
11678
294
2338
1.31
4.13
2.7
2.7
0.9
1.3
e6/l
1.12
167
1333
92
593
1.58
4.12
6.4
4.9
1.6
1.6
%
0.24
84
551
24
98
2.47
4.05
3.0
1.9
1.0
1.1
e9/l
0.31
15
60
1246
11668
1.25
4.04
20.3
16.2
38.9
38.9
%
0.04
777
7799
443
3732
1.25
3.91
3.3
3.1
—
—
—
0
0
150
1086
1.42
3.84
1.6
1.4
—
—
—
0
0
381
3168
1.26
3.75
1.9
1.7
440.4
25039185.7
pmol/l
2.40
318
2580
1040
9589
1.22
3.75
4.6
4.0
—
—
—
0
0
526
4534
1.23
3.75
6.2
5.6
—
—
—
0
0
1156
10773
1.23
3.74
22.3
18.3
13.9
13.8
%
1.51
1137
10511
92
616
1.52
3.52
2.2
2.0
2.6
2.5
ug/l
0.04
78
549
199
1533
1.34
3.50
1.6
1.4
—
—
—
0
0
399
3366
1.24
3.44
4.8
3.7
88.6
87.8
%
0.23
388
3281
59
358
1.67
3.41
1.5
1.4
273.8
268.3
ug/g
0.08
35
214
52
305
1.73
3.40
1.7
2.2
127.5
127.4
g/l
0.00
40
233
211
1650
1.32
3.35
1.3
1.3
451.7
542.6
titre
0.30
41
359
33
170
1.96
3.25
1.3
1.6
62.7
66.1
%
0.16
16
102
96
666
1.47
3.13
1.4
1.2
—
—
—
0
0
268
2184
1.27
3.11
1.3
1.3
23.8
39.9
iu/ml
2.38
83
698
260
2118
1.27
3.02
1.3
1.2
10.6
13.3
u/ml
0.26
89
803
18
75
2.41
2.97
2.3
1.8
14.1
13.4
%
—
10
30
67
436
1.56
2.96
11.9
10.2
—
—
—
0
0
13
46
2.84
2.92
3.5
2.4
—
—
—
0
0
100
710
1.43
2.91
1.2
1.2
116.0
216.0
u/ml
2.13
88
647
18
76
2.38
2.89
2.3
1.8
76.4
72.6
%
0.39
18
71
415
3575
1.21
2.88
2.7
2.7
3902.9
7148.7
umol/l
0.79
345
3067
331
2787
1.23
2.88
5.5
4.5
—
—
—
0
0
73
490
1.51
2.82
1.1
1.1
1.2
2.0
u/ml
—
5
6
598
5346
1.18
2.74
2.2
2.1
—
—
—
0
0
243
1995
1.25
2.65
2.7
2.4
2.4
2.3
g/l
1.91
225
1841
175
1382
1.30
2.62
4.3
3.4
—
7.4
—
0
5
9
25
3.61
2.57
1.2
1.6
—
—
—
0
0
260
2166
1.24
2.49
2.7
2.4
13.0
12.8
umol/l
0.12
238
1992
270
2260
1.23
2.48
3.2
3.1
0.8
0.8
mmol/l
0.10
249
2096
159
1253
1.30
2.43
8.4
6.7
11.3
10.6
mmol/l
0.48
146
1184
161
1272
1.29
2.41
3.6
2.4
7.4
7.0
ug/l
0.06
137
1110
16
70
2.30
2.41
3.0
2.6
43.9
41.9
%
—
10
25
154
1211
1.30
2.39
2.1
2.2
32.0
38.8
u/l
1.50
126
1027
203
1653
1.26
2.39
2.7
2.5
1.7
1.8
%
0.86
177
1467
174
1391
1.28
2.38
2.1
2.1
126.0
147.4
ug/g
0.37
144
1076
1382
13305
1.20
2.35
5.2
5.1
2.6
2.7
mmol/l
0.78
1262
12056
273
2301
1.22
2.35
1.4
1.5
2.6
2.5
g/l
0.10
165
1367
474
4207
1.18
2.31
4.3
4.1
—
—
—
0
0
21
105
2.01
2.31
1.2
1.2
—
—
—
0
0
9
28
3.23
2.30
2.7
3.9
—
—
—
0
0
10
35
2.87
2.30
2.5
2.1
14.2
10.1
%
—
10
30
115
873
1.34
2.30
3.2
3.1
4.3
4.2
e9/l
0.16
88
659
499
4474
1.16
2.12
5.6
5.2
2.7
3.2
ug/l
0.67
450
3969
1348
12987
1.18
2.08
4.7
4.6
4.6
4.6
mmol/l
0.25
1247
11850
60
415
1.46
2.08
2.9
3.4
—
—
—
0
0
5
10
5.01
2.07
1.0
1.0
—
—
—
0
0
19
96
1.99
2.05
3.1
2.3
—
—
—
0
0
34
208
1.65
2.02
2.3
2.7
—
—
—
0
0
222
1863
1.22
2.01
2.8
2.5
21.8
22.9
%
0.57
180
1588
20
104
1.93
2.00
1.1
1.2
—
—
—
0
0
9
32
2.82
2.00
1.1
1.4
—
—
—
0
0
328
2856
1.18
2.00
2.8
2.7
527.0
549.4
mosm/kgh2o
1.23
283
2441
164
1337
1.25
1.94
4.4
3.3
2.1
2.0
mmol/l
0.07
132
1062
36
227
1.60
1.91
1.3
1.3
—
—
—
0
0
15
72
2.09
1.86
4.0
1.9
585.9
736.0
e6/l
—
9
29
10
40
2.51
1.83
1.6
2.5
—
—
—
0
0
255
2189
1.19
1.83
2.8
2.9
2.9
2.2
e6/l
0.43
130
1191
86
650
1.34
1.82
4.0
3.5
23.8
24.1
mmol/l
0.37
70
581
23
130
1.78
1.82
1.1
1.3
14083.4
131708.8
e6/l
0.92
13
90
169
1396
1.23
1.80
1.3
1.3
—
—
—
0
0
1291
12443
1.15
1.78
4.2
4.1
1.2
1.3
mmol/l
2.22
1176
11175
6
18
3.34
1.74
8.8
8.2
—
—
—
0
0
397
3547
1.16
1.74
3.9
3.6
—
—
—
0
0
25
148
1.70
1.70
1.6
1.5
—
—
—
0
0
25
148
1.70
1.70
1.6
1.5
—
—
—
0
0
25
148
1.70
1.70
1.6
1.5
—
—
—
0
0
25
148
1.70
1.70
1.6
1.5
—
—
—
0
0
1331
12874
1.15
1.68
4.6
4.5
1.5
1.5
mmol/l
4.07
1223
11654
49
343
1.44
1.65
1.4
1.6
7951.0
18921.7
e6/l
1.44
41
248
7
25
2.81
1.65
7.7
7.2
—
—
—
0
0
114
911
1.27
1.63
4.1
3.5
7.4
7.4
ph
3.11
15
125
1287
12432
1.14
1.61
6.2
6.1
40.1
40.4
mmol/mol
0.77
1193
11358
115
924
1.26
1.58
4.1
3.5
5.1
5.2
kpa
0.62
107
845
7
26
2.70
1.58
1.1
1.0
—
—
—
0
0
22
129
1.71
1.57
1.1
1.5
21.8
27.0
%
—
10
78
151
1253
1.22
1.56
2.5
2.6
66.4
66.4
g/l
0.01
134
1153
24
145
1.66
1.54
1.3
1.2
—
—
—
0
0
77
590
1.32
1.53
2.0
1.9
—
—
—
0
0
98
778
1.28
1.50
1.1
1.2
188.3
148.0
iu/ml
0.29
34
288
116
942
1.25
1.48
3.6
3.1
—
—
—
0
0
104
834
1.26
1.47
1.2
1.3
—
—
—
0
0
309
2747
1.15
1.46
2.7
3.0
2.5
2.5
mmol/l
0.46
271
2409
9
38
2.38
1.45
39.9
30.1
7.5
6.9
ug/l
—
9
33
92
730
1.28
1.43
4.3
3.1
25.5
25.3
mmol/l
0.23
92
708
29
190
1.54
1.37
3.4
2.1
—
—
—
0
0
16
89
1.81
1.37
1.8
1.6
—
—
—
0
0
112
915
1.24
1.37
1.3
1.2
—
—
—
0
0
92
736
1.26
1.35
2.6
3.4
4.3
4.4
pmol/l
0.50
85
636
138
1155
1.21
1.34
2.5
2.1
365.3
371.8
nmol/l
0.14
128
1052
0
37
0.00
1.34
0.0
2.2
—
143.8
—
0
32
17
284
0.59
1.34
1.2
1.4
62.3
245.4
pmol/l
2.43
17
279
26
169
1.55
1.29
4.3
5.8
8.6
7.2
mmol/l
0.61
17
142
134
1124
1.21
1.28
4.3
3.6
96.2
93.1
ng/l
0.12
111
961
9
44
2.05
1.27
1.1
1.1
1313.8
1622.6
miu/ml
—
9
44
24
155
1.56
1.23
1.1
1.1
—
—
—
0
0
125
1049
1.21
1.20
2.5
2.4
—
—
—
0
0
25
164
1.53
1.20
1.2
1.2
2.8
5.1
u/ml
0.80
11
71
24
156
1.55
1.20
1.2
1.2
—
—
—
0
0
145
1235
1.19
1.19
2.5
2.6
67.7
70.1
e9/l
0.44
118
948
11
57
1.94
1.17
1.4
1.3
—
—
—
0
0
197
1726
1.16
1.16
1.3
1.3
—
—
—
0
0
64
811
0.78
1.15
1.3
1.4
—
—
—
0
0
169
1464
1.17
1.15
4.8
4.4
—
—
—
0
0
12
65
1.85
1.13
3.3
1.8
8.4
10.0
mmol/l
—
7
53
60
467
1.30
1.13
2.2
2.0
21.8
21.3
s
0.31
52
419
12
66
1.82
1.09
1.2
1.2
139.7
138.1
nmol/l
0.04
12
66
12
66
1.82
1.09
1.0
1.1
8.0
11.2
iu/ml
—
7
10
387
3560
1.11
1.07
1.7
1.6
1.3
1.3
mmol/l
0.53
324
2950
17
105
1.63
1.06
1.2
1.2
—
—
—
0
0
39
288
1.36
1.05
2.8
2.7
—
—
—
0
0
72
584
1.24
1.00
1.3
1.2
—
—
—
0
0
13
76
1.72
0.99
2.7
3.7
—
—
—
0
0
29
206
1.41
0.99
1.4
1.2
—
—
—
0
0
5
23
2.18
0.98
1.2
1.0
—
—
—
0
0
49
380
1.30
0.97
4.4
3.7
—
—
—
0
0
0
30
0.00
0.97
0.0
1.3
—
61.3
—
0
25
15
92
1.64
0.97
2.7
1.4
—
66.0
—
0
6
38
285
1.34
0.95
4.6
2.5
42.9
34.3
umol/l
0.57
33
239
14
85
1.65
0.94
2.1
1.8
51.2
43.7
%
—
5
10
30
217
1.39
0.93
1.4
1.3
—
—
—
0
0
81
672
1.22
0.92
1.4
1.8
1.5
1.6
g/l
0.32
65
585
91
767
1.20
0.89
3.2
3.7
—
—
—
0
0
27
370
0.73
0.89
1.2
1.1
—
—
—
0
0
34
254
1.35
0.88
1.4
1.5
—
—
—
0
0
8
42
1.91
0.88
2.0
1.8
—
—
—
0
0
8
42
1.91
0.88
2.1
1.6
—
—
—
0
0
21
144
1.46
0.87
1.8
2.1
—
—
—
0
0
42
325
1.30
0.87
4.5
3.6
25.2
27.2
mg/l
0.15
26
207
43
334
1.29
0.86
3.5
4.0
—
—
—
0
0
79
660
1.21
0.86
4.5
3.5
—
—
—
0
0
24
170
1.42
0.85
2.1
1.5
0.5
0.8
g/l
0.85
13
136
15
96
1.57
0.84
1.2
1.5
—
—
—
0
0
26
188
1.39
0.83
1.3
1.4
1300.4
1679.0
e6/l
0.53
21
138
17
113
1.51
0.82
2.5
2.5
—
—
—
0
0
6
32
1.88
0.82
1.0
1.0
—
—
—
0
0
6
32
1.88
0.82
1.0
1.1
—
—
—
0
0
13
81
1.61
0.81
1.0
1.1
3.6
2.7
u/ml
—
7
31
14
89
1.58
0.81
1.0
1.0
1.8
2.8
u/ml
—
7
32
12
188
0.64
0.80
1.0
1.1
—
—
—
0
0
0
28
0.00
0.76
0.0
1.1
—
—
—
0
0
23
166
1.39
0.75
1.2
1.4
37123.1
94741.8
e6/l
0.57
12
103
143
1271
1.14
0.75
2.2
2.0
0.2
0.2
g/l
0.10
128
1180
25
184
1.36
0.74
4.1
1.3
—
—
—
0
0
8
132
0.60
0.73
1.8
1.4
—
—
—
0
0
27
202
1.34
0.72
1.6
1.4
—
—
—
0
0
20
142
1.41
0.72
1.0
1.2
—
33.5
—
0
7
16
109
1.47
0.71
1.8
1.2
—
—
—
0
0
59
492
1.21
0.69
2.4
2.8
0.4
0.3
g/l
0.34
17
181
51
419
1.22
0.68
3.5
4.6
—
—
—
0
0
5
27
1.85
0.68
1.2
1.1
—
—
—
0
0
19
136
1.40
0.67
1.2
1.2
—
—
—
0
0
130
1161
1.13
0.65
4.5
4.1
0.7
0.9
%
0.57
38
359
8
131
0.61
0.63
1.8
1.4
—
—
—
0
0
118
1050
1.13
0.63
4.5
3.9
0.3
0.6
%
2.07
26
251
19
138
1.38
0.62
1.3
1.1
0.1
1.2
u/ml
—
8
54
15
104
1.45
0.62
1.0
1.0
3.2
1.4
u/ml
—
7
23
20
268
0.74
0.62
1.3
1.4
0.8
0.9
nmol/l
0.35
14
221
0
21
0.00
0.60
0.0
1.1
—
42.7
—
0
7
19
140
1.36
0.58
2.8
3.6
—
—
—
0
0
6
35
1.72
0.57
1.5
1.4
—
—
—
0
0
15
106
1.42
0.57
1.4
1.2
3.2
2.8
g/l
—
7
77
15
106
1.42
0.57
1.4
1.2
0.4
0.4
g/l
—
7
78
15
106
1.42
0.57
1.4
1.2
6.7
6.9
g/l
—
7
77
14
98
1.43
0.56
1.7
1.3
—
—
—
0
0
183
1684
1.10
0.56
1.7
1.7
—
—
—
0
0
6
37
1.62
0.55
1.7
2.7
—
—
—
0
0
16
216
0.74
0.54
1.6
1.7
—
—
—
0
0
11
74
1.49
0.53
15.3
16.9
—
—
—
0
0
9
135
0.66
0.51
1.7
1.5
—
—
—
0
0
6
40
1.50
0.51
1.0
1.0
—
—
—
0
0
15
109
1.38
0.51
2.3
2.3
—
—
—
0
0
53
454
1.17
0.50
1.4
1.2
0.2
0.9
u/ml
—
9
40
13
179
0.72
0.50
1.5
1.2
—
—
—
0
0
114
1032
1.11
0.49
4.7
4.1
0.0
0.5
%
0.80
28
268
80
710
1.13
0.48
1.5
1.6
—
—
—
0
0
7
46
1.52
0.48
2.0
2.1
262.6
930.1
e6/l
—
7
35
7
47
1.49
0.47
1.1
1.0
—
4.2
—
0
5
7
47
1.49
0.47
1.3
1.9
15.5
5.9
nmol/l
—
7
37
27
218
1.24
0.46
1.3
2.1
7058.3
3094.7
u/l
0.28
14
94
38
319
1.20
0.46
3.0
2.5
—
—
—
0
0
7
49
1.43
0.46
4.6
1.9
17.6
188.6
ug/l
—
7
41
20
156
1.29
0.45
1.3
1.2
—
—
—
0
0
15
112
1.34
0.44
1.3
1.3
13.5
12.9
u/l
0.05
15
102
7
51
1.37
0.44
1.0
1.2
110.3
266.9
iu/ml
—
7
51
13
95
1.37
0.43
1.2
1.2
0.3
1.6
u/ml
—
7
45
47
405
1.17
0.43
4.8
4.5
7.4
7.4
ph
0.11
37
339
9
128
0.70
0.43
1.0
1.3
—
30.4
—
0
9
11
78
1.41
0.43
1.5
1.5
—
—
—
0
0
42
359
1.17
0.43
3.0
3.1
1.6
1.6
mmol/l
0.27
42
351
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
120
1103
1.09
0.41
4.6
4.1
0.1
0.1
%
0.13
33
329
8
59
1.36
0.41
1.1
1.0
—
—
—
0
0
12
160
0.75
0.39
1.8
2.7
—
—
—
0
0
41
353
1.17
0.39
2.5
3.0
0.8
0.8
nmol/l
0.09
33
273
24
196
1.23
0.39
1.2
1.2
—
—
—
0
0
10
137
0.73
0.39
1.6
1.2
—
—
—
0
0
57
505
1.13
0.38
4.6
3.3
64.3
172.9
mg/l
0.47
45
410
5
37
1.35
0.37
1.0
1.0
—
—
—
0
0
5
37
1.35
0.37
2.8
1.9
—
—
—
0
0
15
116
1.30
0.37
6.2
1.4
—
—
—
0
0
15
116
1.30
0.37
1.7
1.6
10.6
11.0
%
0.18
15
116
19
152
1.25
0.37
1.4
1.4
—
—
—
0
0
83
754
1.11
0.37
1.3
1.3
—
—
—
0
0
38
328
1.16
0.36
2.4
2.2
—
—
—
0
0
368
3539
1.05
0.36
1.4
1.4
—
—
—
0
0
21
171
1.23
0.35
1.2
1.2
0.6
0.7
nmol/l
0.36
21
160
26
217
1.20
0.35
4.0
1.4
—
—
—
0
0
6
42
1.43
0.35
1.0
1.2
—
—
—
0
0
11
145
0.76
0.34
1.1
1.2
—
—
—
0
0
10
73
1.37
0.34
1.1
1.0
—
—
—
0
0
6
45
1.33
0.33
2.0
3.2
15.8
20.3
mu/l
—
6
45
608
5925
1.04
0.33
10.3
9.7
0.0
0.0
e9/l
0.38
506
4830
55
492
1.12
0.33
4.7
3.3
6.9
1.7
ratio
—
5
42
127
1187
1.08
0.32
4.3
4.1
—
—
—
0
0
129
1207
1.07
0.31
1.6
1.5
—
—
—
0
0
39
342
1.14
0.31
4.3
4.8
2.5
2.8
mmol/l
0.33
26
234
56
504
1.11
0.31
4.7
3.4
35.4
48.3
mg/l
0.87
44
408
11
84
1.31
0.30
1.0
1.1
—
168.0
—
0
15
54
487
1.11
0.29
1.6
1.7
—
—
—
0
0
7
57
1.23
0.29
1.0
1.2
—
—
—
0
0
19
158
1.20
0.28
1.2
1.2
—
—
—
0
0
8
62
1.29
0.28
1.1
1.1
—
—
—
0
0
8
64
1.25
0.27
1.0
1.1
—
—
—
0
0
127
1196
1.07
0.27
1.4
1.4
—
—
—
0
0
8
65
1.23
0.27
5.9
2.5
524.9
1539.5
u/ml
—
8
65
150
1421
1.06
0.27
1.6
1.5
—
—
—
0
0
35
309
1.14
0.27
1.3
1.3
—
—
—
0
0
439
4270
1.04
0.27
3.0
3.2
791.8
252.1
mg/l
0.98
287
2726
19
159
1.20
0.26
5.3
3.8
—
—
—
0
0
42
376
1.12
0.26
1.3
1.6
1.1
1.2
g/l
0.66
37
359
27
234
1.16
0.26
4.0
1.4
—
—
—
0
0
12
95
1.27
0.26
1.2
1.3
—
—
—
0
0
36
320
1.13
0.25
1.1
1.2
588.9
503.2
mg/l
0.23
36
299
89
830
1.08
0.25
2.2
2.2
11.3
12.7
nmol/l
1.05
76
732
27
235
1.15
0.25
4.0
1.4
—
—
—
0
0
10
78
1.28
0.24
1.6
1.6
—
—
—
0
0
5
38
1.32
0.23
1.4
1.6
—
—
—
0
0
5
38
1.32
0.23
1.8
1.3
25.2
20.3
%
—
5
27
0
10
0.00
0.21
0.0
3.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
42.8
—
0
6
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
16
187
0.85
0.20
2.1
2.1
53.9
1446.7
u/ml
0.48
16
177
26
231
1.13
0.19
4.0
1.4
—
—
—
0
0
6
51
1.18
0.19
1.3
1.2
—
—
—
0
0
53
570
0.93
0.18
2.6
2.7
—
—
—
0
0
17
147
1.16
0.18
1.2
1.6
—
—
—
0
0
19
166
1.15
0.18
2.2
1.9
—
—
—
0
0
30
271
1.11
0.18
1.2
1.3
85.2
220.8
miu/ml
4.84
12
115
461
4523
1.03
0.17
3.6
4.0
9.7
8.6
mg/mmol
0.19
284
2876
5
66
0.76
0.17
4.2
3.1
—
—
—
0
0
8
70
1.14
0.16
4.3
7.1
—
—
—
0
0
33
302
1.09
0.16
1.2
1.2
—
—
—
0
0
43
463
0.93
0.16
2.5
2.0
39.5
37.2
g/l
2.27
38
405
421
4287
0.98
0.15
3.2
3.0
—
—
—
0
0
10
83
1.21
0.15
2.1
2.9
—
—
—
0
0
10
119
0.84
0.15
1.2
1.2
—
—
—
0
0
9
78
1.15
0.15
1.7
2.0
18.7
19.0
nmol/l
—
9
72
9
80
1.13
0.15
1.0
1.1
173.9
242.7
mg/l
—
9
71
13
150
0.87
0.14
1.3
1.3
—
—
nmol/l
—
0
0
11
93
1.18
0.14
1.1
1.1
—
—
—
0
0
449
4417
1.02
0.14
3.1
3.1
6.8
7.2
mmol/l
1.51
380
3674
8
96
0.83
0.13
1.1
1.1
33.8
34.1
mmol/l
—
8
85
8
98
0.82
0.13
1.5
1.1
—
—
—
0
0
26
284
0.91
0.13
4.3
3.5
60.4
59.0
%
0.25
26
284
23
252
0.91
0.12
3.7
2.8
—
—
—
0
0
36
336
1.07
0.12
1.5
1.3
31.0
30.1
iu/l
0.05
31
286
18
162
1.11
0.12
5.4
1.8
—
—
—
0
0
24
220
1.09
0.11
2.2
1.5
—
—
—
0
0
11
126
0.87
0.11
1.5
1.3
—
—
—
0
0
14
124
1.13
0.11
1.1
1.0
1.0
5.0
u/ml
—
9
62
10
86
1.16
0.11
2.7
1.5
0.9
1.0
g/l
—
10
86
10
115
0.87
0.10
2.0
1.9
—
—
—
0
0
128
1246
1.03
0.10
3.2
3.8
1.2
1.2
mmol/l
0.03
108
1076
5
46
1.09
0.09
2.2
2.2
—
—
—
0
0
35
330
1.06
0.09
1.7
1.7
—
—
—
0
0
15
165
0.91
0.09
1.5
1.6
—
—
—
0
0
41
390
1.05
0.08
1.1
1.1
—
—
—
0
0
6
71
0.84
0.07
1.8
1.6
—
—
—
0
0
6
74
0.81
0.07
1.8
2.7
—
—
—
0
0
25
235
1.06
0.07
4.2
1.4
—
—
—
0
0
38
363
1.05
0.07
3.1
2.3
53.3
100.3
ug/min
1.04
26
226
15
163
0.92
0.07
1.2
1.3
—
—
—
0
0
65
669
0.97
0.06
2.3
3.4
25.6
70.5
u/ml
3.50
65
647
13
119
1.09
0.06
1.1
1.3
—
—
—
0
0
10
90
1.11
0.05
1.0
1.1
—
—
—
0
0
32
307
1.04
0.05
1.1
1.2
—
—
—
0
0
27
258
1.05
0.04
1.5
1.5
—
—
—
0
0
130
1318
0.99
0.04
1.6
1.6
—
—
—
0
0
24
251
0.96
0.04
4.1
3.3
0.9
1.3
%
0.46
18
192
26
271
0.96
0.04
3.7
3.3
4.7
4.3
e9/l
0.44
26
271
78
766
1.02
0.03
1.4
1.4
—
—
—
0
0
33
319
1.04
0.03
1.2
1.2
—
—
—
0
0
33
320
1.03
0.03
1.8
2.5
16.9
15.8
%
0.89
19
164
16
152
1.05
0.02
3.8
3.3
56.4
57.1
%
—
9
97
15
157
0.96
0.01
1.3
1.5
—
—
—
0
0
18
187
0.96
0.01
1.0
1.0
—
—
—
0
0
20
207
0.97
0.01
2.4
2.4
—
—
—
0
0
257
2580
1.00
0.01
3.3
3.2
0.9
0.8
ug/l
0.27
184
1786
26
253
1.03
0.01
1.0
1.3
—
—
—
0
0
56
566
0.99
0.00
1.7
1.5
—
10.8
—
0
14
11
105
1.05
0.00
1.0
1.1
—
—
—
0
0
21
205
1.02
0.00
1.2
1.2
290.4
279.8
u/ml
0.07
14
126
15
151
0.99
0.00
1.0
1.1
—
—
—
0
0
15
151
0.99
0.00
1.0
1.1
—
—
—
0
0
35
355
0.99
0.00
1.1
1.1
—
—
—
0
0
44
435
1.01
0.00
1.6
1.6
—
—
—
0
0
31
309
1.00
0.00
1.7
1.8
389.5
5.2
iu/l
—
8
102
43
431
1.00
0.00
1.0
1.1
—
—
—
0
0
14
144
0.97
0.00
1.1
1.1
—
—
—
0
0
57
574
0.99
0.00
1.4
1.4
—
—
—
0
0
24
238
1.01
0.00
1.6
1.3
8.3
10.3
u/l
0.37
19
196
12
122
0.98
0.00
1.4
2.2
1.3
1.5
u/field
—
6
41
14
137
1.02
0.00
1.9
1.6
—
—
—
0
0
7
71
0.99
0.00
1.6
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
8.0
—
—
—
0
0
13
130
1.00
0.00
1.6
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
9.2
—
9.2
—
0
5
7
72
0.97
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
7.9
—
0
5
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
7
73
0.96
0.00
1.6
1.4
1.2
1.2
nmol/l
—
7
59
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.6
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
0.5
—
0
7
9
95
0.95
0.00
1.2
1.2
2.7
2.0
mmol/l
—
9
90

Mortality – FinRegistry

Association

Association between endpoint K11_FEMHER and mortality.

Females

Parameter HR [95% CI] p-value
K11_FEMHER 1.32 [1.19, 1.47] < 0.001
Birth year 0.994 [0.99, 1.0] 0.14

During the follow-up period (1.1.1998 — 31.12.2019), 1345 out of 4553 females with K11_FEMHER died.

Males

Parameter HR [95% CI] p-value
K11_FEMHER 1.088 [0.97, 1.22] 0.154
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 907 out of 3097 males with K11_FEMHER died.

Mortality risk

Mortality risk for people of age

years, who have K11_FEMHER.

N-year risk Females Males
1 0.138% 0.184%
5 0.714% 1.181%
10 1.955% 3.021%
15 3.699% 5.616%
20 6.236% 9.907%

Relationships between endpoints

Index endpoint: K11_FEMHER – Femoral hernia

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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