No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
983 |
4. Check minimum number of eventsNone |
983 |
5. Include endpointsNone |
983 |
6. Filter based on genotype QC (FinnGen only) |
983 |
Control definitions (FinnGen only)
- Control exclude
- K11_HERNIA
Extra metadata
- First used in FinnGen datafreeze
- DF3
Similar endpoints
↥List of similar endpoints to
Inguinal hernia, unilateral
based on the number of shared cases.
Similar with more cases:
- Femoral hernia, unilateral
- Inguinal of femoral hernia, unilateral
- Femoral hernia
- Hernia
- Gastrointestinal diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8437 | 5168 | 3231 |
| Only index persons | 7546 | 4656 | 2890 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.15 | 0.09 |
| Only index persons | 0.15 | 0.17 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 64.81 | 66.55 | 61.92 |
| Only index persons | 62.89 | 64.41 | 60.44 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 983 | 565 | 418 |
| Unadjusted period prevalence (%) | 0.19 | 0.19 | 0.18 |
| Median age at first event (years) | 60.63 | 58.76 | 63.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 863
- Matched controls
- 8630
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K41.9
ICD-10 Finland
Unilateral or unspecified femoral hernia, without obstruction or gangrene
+∞
323.0
640
*
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
553.4
323.0
451
17
JAB30
NOMESCO Finland
Repair of inguinal hernia using prosthetic material
764.0
286.5
267
5
K41.3
ICD-10 Finland
Unilateral or unspecified femoral hernia, with obstruction, without gangrene
+∞
244.8
223
*
JAC10
NOMESCO Finland
Repair of femoral hernia
+∞
149.4
139
*
JAC30
NOMESCO Finland
Repair of femoral hernia using prosthetic material
1596.3
142.9
135
*
JAB11
NOMESCO Finland
Laparoscopic repair of inguinal hernia
1349.9
123.1
117
*
K40.3
ICD-10 Finland
Unilateral or unspecified inguinal hernia, with obstruction, without gangrene
+∞
108.7
102
*
JAC11
NOMESCO Finland
Laparoscopic repair of femoral hernia
+∞
62.2
59
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
32.4
58.3
77
26
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
62.7
55.3
64
11
JAB10
NOMESCO Finland
Repair of inguinal hernia
+∞
54.8
52
*
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
55.5
52.6
62
12
K41.4
ICD-10 Finland
Unilateral or unspecified femoral hernia, with gangrene
+∞
47.3
45
*
K40.2
ICD-10 Finland
Bilateral inguinal hernia, without obstruction or gangrene
165.4
45.3
47
*
D89
ICPC
Inguinal hernia
82.8
42.3
47
6
JAB12
NOMESCO Finland
Laparoscopic repair of inguinal hernia, TEP
+∞
41.0
39
*
6123
FHL
Radical surgery
214.9
40.2
41
*
55099
ICD-8 Finland
Inguinal hernia without mention of obstruction
+∞
37.8
36
*
K40
ICD-10 Finland
Inguinal hernia
50.1
36.0
43
9
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
3.0
31.9
221
896
JAF10
NOMESCO Finland
Repair of umbilical hernia
42.9
30.1
37
9
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
13.1
28.9
51
41
JAC12
NOMESCO Finland
Laparoscopic repair of femoral hernia, TEP
+∞
27.2
26
*
JFB00
NOMESCO Finland
Partial resection of small intestine
13.4
23.6
41
32
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
23.0
321
1843
5509B
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,LATERALIS (SCROT]
+∞
20.9
20
*
JAF30
NOMESCO Finland
Repair of umbilical hernia using prosthetic material
214.9
20.7
21
*
N02BE01
ATC
paracetamol; systemic, rectal
2.4
20.2
746
6260
ZXA00
NOMESCO Finland
Right side
2.1
19.9
277
1565
5509A
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,MEDIALIS]
+∞
19.9
19
*
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
107.5
19.6
21
*
ZXA05
NOMESCO Finland
Left side
2.1
17.9
255
1442
JAD11
NOMESCO Finland
Laparoscopic repair of incisional hernia
+∞
17.8
17
*
WX320
NOMESCO Finland
Spinalanesthesy
2.1
16.4
219
1199
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
15.1
242
1422
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.6
14.7
113
470
K43.0
ICD-10 Finland
Incisional hernia with obstruction, without gangrene
+∞
14.6
14
*
K40.4
ICD-10 Finland
Unilateral or unspecified inguinal hernia, with gangrene
+∞
14.6
14
*
K41
ICD-10 Finland
Femoral hernia
+∞
13.6
13
*
JAC96
NOMESCO Finland
Other repair of femoral hernia
+∞
12.5
12
*
N02AX02
ATC
tramadol; systemic, rectal
1.7
12.4
353
2476
SPAT1153
SPAT
Removal of sutures
1.8
12.0
279
1839
J01CA04
ATC
amoxicillin; systemic
1.7
11.7
644
5419
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
11.6
236
1486
K59.09
ICD-10 Finland
Constipation, unspecified
3.1
11.5
65
222
6124
FHL
Radical cutting and plastic with foreign material
+∞
11.5
11
*
K42.0
ICD-10 Finland
Umbilical hernia with obstruction, without gangrene
+∞
11.5
11
*
G04CA02
ATC
tamsulosin; oral
1.9
11.5
197
1172
JAH01
NOMESCO Finland
Laparoscopy
3.8
11.4
48
132
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
11.4
178
1019
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.6
10.7
80
328
M54.5
ICD-10 Finland
Low back pain
1.7
10.6
265
1771
B01AB05
ATC
enoxaparin; parenteral
1.7
10.6
266
1779
WX402
NOMESCO Finland
General anaesthesia
2.0
10.5
134
710
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.3
10.5
99
459
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
10.5
360
2630
JAF11
NOMESCO Finland
Laparoscopic repair of umbilical hernia
+∞
10.4
10
*
A02BC02
ATC
pantoprazole; systemic
1.6
10.3
534
4332
SPAT1263
SPAT
Sampling
1.6
10.0
347
2528
S18
ICPC
Laceration/cut
1.6
9.8
339
2466
JAD10
NOMESCO Finland
Repair of incisional hernia
55.6
9.7
11
*
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
9.2
9.6
19
21
WX110
NOMESCO Finland
Local anesthesy
1.6
9.5
527
4302
M79.6
ICD-10 Finland
Pain in limb
1.6
9.4
283
1977
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
9.4
361
2689
JAB97
NOMESCO Finland
Other laparoscopic repair of inguinal hernia
+∞
9.4
9
*
JAB91
NOMESCO Finland
Repair of recurrent inguinal hernia, endoscopy
+∞
9.4
9
*
JAB96
NOMESCO Finland
Other repair of inguinal hernia
+∞
9.4
9
*
UJF32
NOMESCO Finland
Coloscopy
1.7
9.2
217
1417
PHD99
NOMESCO Finland
Resection of other vein
2.6
9.2
65
259
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
9.1
286
2024
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
9.0
175
1079
SPAT1301
SPAT
No procedures
1.6
9.0
264
1831
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
2.6
8.8
66
270
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.8
8.2
146
871
103
Kela drug reimbursment
Diabetes, insulin-treated
0.5
8.2
97
1632
N03AX12
ATC
gabapentin; oral
1.9
8.1
128
734
R03AC02
ATC
salbutamol; inhalant
1.5
8.1
405
3180
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.4
8.0
70
312
D91
ICPC
Abdominal hernia other
22.3
8.0
11
5
A02BC05
ATC
esomeprazole; systemic
1.5
7.9
316
2350
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
7.9
173
1098
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
7.9
219
1490
PHD76
NOMESCO Finland
Resection of long saphenous vein
2.7
7.7
51
197
M54.4
ICD-10 Finland
Lumbago with sciatica
1.9
7.7
125
721
J01DB01
ATC
cefalexin; oral
1.6
7.6
648
5682
WX704
NOMESCO Finland
Intubation
2.3
7.5
66
296
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
7.4
159
1003
LEF03
NOMESCO Finland
Posterior colporrpahy with sutures for primary rectocele
3.1
7.3
38
126
5509X
ICD-9 Finland
Inguinal hernia, without mention of obstruction or gangrene[HERNIA INGUINALIS SINE GANGR/OBSTR,ALIA SEU NUD]
+∞
7.3
7
*
K41.2
ICD-10 Finland
Bilateral femoral hernia, without obstruction or gangrene
+∞
7.3
7
*
D06
ICPC
Abdominal pain localized other
2.3
7.2
65
296
B01AF02
ATC
apixaban; oral
2.0
7.1
85
439
R52.2
ICD-10 Finland
Other chronic pain
3.2
7.0
35
114
L12
ICPC
Hand/finger symptom/complaint
1.9
6.9
110
631
J45.1
ICD-10 Finland
Nonallergic asthma
2.3
6.9
60
267
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.7
6.9
141
877
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
6.9
278
2057
R13
ICD-10 Finland
Dysphagia
2.4
6.9
55
237
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
2.0
6.8
86
452
K45.8
ICD-10 Finland
Other specified abdominal hernia without obstruction or gangrene
40.4
6.8
8
*
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
2.4
6.7
54
235
R51.80
ICD-10 Finland
Headache
1.9
6.6
105
601
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
6.6
328
2536
N03AX16
ATC
pregabalin; oral
1.6
6.5
186
1267
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.2
6.5
65
310
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.6
6.5
170
1131
WX725
NOMESCO Finland
Noninvasive ventilation
2.6
6.3
42
164
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
6.3
192
1330
JAB93
NOMESCO Finland
Repair of recurrent inguinal hernia, implantation
+∞
6.3
6
*
K43.2
ICD-10 Finland
Incisional hernia without obstruction or gangrene
+∞
6.3
6
*
JN3AD
NOMESCO Finland
Abdominal CT examination
2.1
6.2
65
318
N06AA09
ATC
amitriptyline; systemic
2.0
6.1
81
435
M01AE02
ATC
naproxen; oral, rectal
1.4
6.1
414
3386
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
536
3607
2.07
27.09
4.7
4.0
—
—
—
0
0
590
4662
1.66
13.19
5.7
4.7
6.5
6.8
mmol/l
3.57
559
4369
345
2435
1.64
11.67
3.2
2.3
55.7
56.8
u/l
0.25
312
2247
867
7744
2.01
11.44
19.1
14.4
25.4
24.9
mg/l
0.13
715
6155
476
3655
1.59
11.23
6.8
5.8
1.2
1.2
mmol/l
0.41
431
3276
638
5262
1.61
10.96
5.6
4.5
880.8
2607.3
e6/l
0.85
16
102
522
4119
1.57
10.77
6.5
6.0
10.7
11.4
umol/l
1.32
492
3899
456
3497
1.57
10.61
5.3
4.5
35.2
35.2
g/l
0.02
422
3231
718
6125
1.64
10.45
8.4
7.2
76.0
79.4
u/l
1.63
680
5707
510
4026
1.55
10.34
7.5
6.5
1.2
1.2
mmol/l
0.22
443
3360
289
2014
1.62
10.00
2.3
2.1
3.0
3.0
mg/l
0.06
251
1684
155
911
1.83
9.99
7.1
7.8
1.1
1.3
mmol/l
0.19
123
705
687
5826
1.60
9.96
4.6
4.0
11.1
13.2
mm/h
3.95
645
5346
155
918
1.82
9.73
7.2
7.7
5.0
5.1
kpa
1.15
147
874
155
919
1.82
9.69
7.2
7.7
11.3
11.9
kpa
0.88
147
879
888
8115
1.98
9.21
21.9
16.9
139.5
139.7
mmol/l
0.94
875
7867
551
4492
1.52
9.17
8.7
8.9
4.2
4.2
e9/l
0.14
485
3911
889
8135
1.97
9.07
21.9
17.1
4.0
4.0
mmol/l
0.36
873
7874
225
1518
1.63
8.73
4.2
3.8
197.0
415.7
ng/l
1.56
181
1227
265
1864
1.58
8.62
2.4
2.4
—
—
—
0
0
418
3253
1.50
8.49
3.0
2.7
127.4
137.0
ug/l
0.26
385
2956
402
3150
1.47
7.66
4.5
3.7
33.9
63.8
ng/l
1.05
292
2276
332
2505
1.49
7.66
3.1
3.0
1400.2
1449.8
ng/l
0.10
291
2163
272
1973
1.52
7.57
1.6
1.5
21.0
21.0
nmol/l
0.01
228
1650
156
1000
1.67
7.32
6.8
7.1
103.5
104.2
mmol/l
0.99
148
978
891
8258
1.84
7.29
11.9
10.3
23.2
25.3
u/l
2.07
871
7915
117
696
1.77
7.18
5.7
7.4
1.2
1.4
mmol/l
0.82
112
665
195
1327
1.59
7.18
1.7
1.8
—
—
—
0
0
514
4266
1.43
6.98
2.8
2.7
—
—
—
0
0
888
8242
1.80
6.95
21.9
17.2
78.3
78.7
umol/l
0.13
888
8242
915
8573
1.97
6.94
27.7
21.5
133.0
134.0
g/l
1.48
908
8412
357
2820
1.42
6.18
3.5
3.4
2.4
2.4
mmol/l
0.40
299
2434
230
1673
1.49
6.16
1.9
1.7
1.2
1.2
mg/l
0.01
175
1292
831
7633
1.57
6.13
4.8
4.7
5.8
6.0
mmol/l
5.13
765
6853
219
1580
1.50
6.10
1.7
1.8
1266.7
1186.2
nmol/l
0.54
166
1164
141
923
1.62
6.05
1.6
1.8
—
—
—
0
0
113
699
1.70
6.04
3.1
3.0
193.2
212.0
ng/l
0.26
100
647
416
3394
1.39
5.89
2.0
2.0
93.8
94.9
pmol/l
0.16
197
1704
88
514
1.78
5.76
8.6
6.8
24.2
24.6
mmol/l
0.50
81
481
158
1079
1.55
5.66
26.8
25.4
1.3
1.3
inr
0.09
15
151
130
848
1.61
5.66
3.9
4.1
5.1
17.6
ug/l
1.35
109
706
401
3270
1.38
5.62
2.5
2.2
81.9
78.6
nmol/l
1.37
353
2887
138
915
1.59
5.61
1.6
1.8
—
—
—
0
0
72
403
1.85
5.42
7.5
10.9
24.6
24.5
mmol/l
0.07
66
379
229
1705
1.45
5.37
5.8
4.1
1.0
1.0
kg/l
0.09
36
248
456
3822
1.36
5.28
4.6
3.7
0.0
0.0
estimate
0.00
74
747
460
3882
1.35
5.01
4.7
3.8
0.0
0.0
estimate
0.80
75
734
125
836
1.57
4.90
3.3
2.6
7.8
7.3
umol/l
0.06
106
726
453
3842
1.33
4.65
6.1
5.1
0.0
0.0
estimate
0.50
74
752
133
914
1.53
4.61
3.0
4.2
233.4
253.7
u/l
0.85
121
862
558
4892
1.33
4.48
3.5
3.0
39.4
51.0
u/l
3.52
518
4522
307
2477
1.35
4.36
2.2
2.1
437.0
198.2
u/l
0.49
294
2303
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
52
283
1.88
4.32
4.6
2.4
0.4
0.4
u/ml
0.37
31
152
301
2433
1.34
4.20
4.5
3.0
27.0
32.8
u/l
4.38
284
2299
150
1078
1.46
4.18
5.8
5.0
1.0
1.0
mmol/l
0.11
137
994
171
1277
1.41
3.87
3.3
3.1
0.8
0.8
mmol/l
0.01
156
1189
96
642
1.55
3.78
3.1
2.7
65.2
63.2
ml/min/173m2
0.24
41
282
140
1014
1.44
3.75
9.4
7.0
—
—
—
0
0
654
5944
1.30
3.64
4.2
4.0
15.0
14.9
pmol/l
0.59
595
5337
694
6360
1.31
3.61
21.9
17.8
13.9
13.8
%
1.01
684
6203
742
6877
1.32
3.47
20.1
15.8
39.1
39.2
%
0.06
470
4655
769
7171
1.33
3.39
5.2
4.7
1.9
2.1
mu/l
0.54
709
6470
177
1360
1.37
3.37
2.6
2.7
1.1
1.1
e6/l
0.13
98
779
223
1783
1.32
3.26
1.8
1.7
433.5
21640682.2
pmol/l
1.50
189
1451
8
15
5.37
3.19
4.2
2.3
—
—
—
0
0
56
343
1.67
3.19
6.6
4.8
1.7
1.6
%
0.62
50
319
75
498
1.55
3.09
1.4
1.6
—
—
—
0
0
11
34
3.26
3.06
3.4
2.1
0.2
0.2
e9/l
0.04
11
29
11
34
3.26
3.06
3.4
2.1
344.6
471.5
e6/l
0.70
11
29
142
1070
1.38
3.05
1.5
1.4
—
—
—
0
0
92
642
1.48
3.01
4.0
3.7
101.1
89.3
ng/l
0.40
76
567
58
365
1.63
2.99
4.7
3.4
24.0
24.2
mmol/l
0.17
48
333
217
1748
1.31
2.99
2.8
2.5
4.9
5.9
e6/l
0.54
196
1536
300
2522
1.27
2.97
5.6
5.1
2.3
3.0
ug/l
0.84
272
2231
99
704
1.45
2.94
2.1
2.2
32.2
35.1
u/l
0.45
85
584
99
704
1.45
2.94
8.9
6.8
11.1
10.7
mmol/l
0.19
90
668
259
2143
1.28
2.91
5.5
4.0
0.0
0.0
estimate
0.69
69
726
249
2050
1.29
2.91
5.5
4.4
22.6
21.7
%
0.47
130
1032
17
71
2.42
2.81
2.1
1.8
—
—
—
0
0
20
91
2.22
2.75
1.3
1.4
61.1
66.3
%
—
10
59
268
2245
1.27
2.70
3.3
3.1
0.5
0.5
e6/l
0.22
205
1707
38
220
1.76
2.68
1.2
1.4
—
—
—
0
0
824
7831
1.32
2.67
5.2
5.1
2.7
2.7
mmol/l
0.41
760
7122
162
1286
1.31
2.47
1.3
1.2
10.8
13.0
u/ml
0.13
57
489
14
57
2.48
2.45
2.5
2.3
13.2
13.2
%
0.05
14
57
26
138
1.91
2.43
7.8
5.9
285.0
224.6
iu/ml
—
9
18
32
182
1.78
2.42
1.2
1.1
—
—
—
0
0
154
1219
1.31
2.40
2.4
2.1
29.7
29.9
s
0.16
149
1184
101
752
1.38
2.36
4.4
3.2
2.0
2.1
mmol/l
0.14
80
593
32
184
1.76
2.34
1.4
1.4
—
—
—
0
0
43
269
1.63
2.33
3.0
2.7
—
—
—
0
0
17
78
2.20
2.32
2.1
1.7
—
—
—
0
0
343
2998
1.22
2.30
5.4
4.0
—
—
—
0
0
153
1220
1.30
2.27
2.6
2.4
12.9
12.9
umol/l
0.04
140
1118
804
7668
1.27
2.17
4.7
4.5
4.7
4.6
mmol/l
0.34
750
7017
191
1580
1.26
2.12
1.2
1.2
0.6
1.8
u/ml
2.63
47
416
141
1123
1.30
2.11
2.7
2.4
2.3
2.3
g/l
0.22
130
1039
63
440
1.46
2.11
1.2
1.2
146.4
179.9
u/ml
0.34
57
396
36
222
1.65
2.08
1.6
1.4
278.4
284.1
ug/g
0.07
25
135
163
1326
1.27
2.07
1.2
1.3
26.2
38.9
iu/ml
0.94
50
423
17
82
2.09
2.07
1.2
1.5
—
—
—
0
0
797
7606
1.25
2.06
4.6
4.5
1.6
1.5
mmol/l
4.20
738
6905
50
335
1.52
2.05
1.7
1.8
—
—
—
0
0
14
66
2.14
1.82
1.3
1.5
—
—
—
0
0
14
66
2.14
1.82
1.3
1.5
—
—
—
0
0
14
66
2.14
1.82
1.3
1.5
—
—
—
0
0
768
7329
1.22
1.81
4.2
4.0
1.2
1.3
mmol/l
4.24
708
6606
14
67
2.11
1.76
1.0
1.1
—
—
—
0
0
28
171
1.66
1.72
1.5
2.2
132.1
128.2
g/l
0.35
21
130
18
96
1.89
1.71
1.3
1.2
2.6
2.8
u/ml
—
7
25
30
187
1.62
1.70
5.0
3.7
23.6
27.0
mg/l
0.24
20
122
45
309
1.48
1.69
1.8
1.8
—
—
—
0
0
53
378
1.43
1.64
4.0
3.5
42.8
47.9
%
0.92
53
371
11
49
2.26
1.64
1.5
1.4
—
391.3
—
0
8
18
98
1.85
1.62
1.3
1.2
3.1
6.7
u/ml
—
8
37
26
159
1.65
1.60
1.7
1.5
—
—
—
0
0
153
1281
1.23
1.54
2.7
2.9
3.2
2.3
e6/l
0.39
75
705
48
343
1.42
1.49
2.6
1.8
2.8
2.6
ug/l
0.05
41
301
236
2070
1.18
1.46
2.6
2.6
4444.7
7779.7
umol/l
0.50
196
1772
91
727
1.28
1.38
2.8
2.4
9.5
7.0
ug/l
0.37
77
631
6
23
2.62
1.37
1.0
1.1
—
—
—
0
0
126
1050
1.23
1.34
2.9
2.5
21.5
22.8
%
0.48
101
891
10
47
2.14
1.34
1.5
1.4
—
56.0
—
0
5
11
54
2.05
1.33
1.2
1.4
18.8
14.2
u/l
0.33
11
49
50
371
1.37
1.28
1.4
1.9
1.6
1.6
g/l
0.03
42
327
8
35
2.30
1.27
1.1
1.4
—
—
—
0
0
186
1619
1.18
1.26
2.8
3.0
2.5
2.5
mmol/l
0.13
165
1418
60
460
1.32
1.25
1.7
1.4
—
—
—
0
0
5
19
2.64
1.21
4.2
2.5
—
—
—
0
0
5
19
2.64
1.21
4.2
2.5
—
—
—
0
0
56
430
1.32
1.17
2.3
3.3
4.4
4.4
pmol/l
0.20
51
374
7
30
2.34
1.12
1.3
1.7
—
—
—
0
0
7
30
2.34
1.12
1.3
1.7
—
—
—
0
0
7
30
2.34
1.12
1.3
1.7
—
—
—
0
0
15
88
1.72
1.11
1.1
1.1
—
—
—
0
0
10
51
1.97
1.11
1.6
1.2
—
—
—
0
0
10
51
1.97
1.11
1.6
1.2
—
—
—
0
0
7
33
2.13
1.05
1.1
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
22
2.28
1.03
3.2
2.3
113.0
127.3
%
—
5
22
18
114
1.59
1.03
1.2
1.1
—
—
—
0
0
73
593
1.25
1.02
1.7
1.6
—
—
—
0
0
52
406
1.30
0.99
3.5
2.9
25.1
25.2
mmol/l
0.11
52
394
106
899
1.20
0.99
3.0
3.3
—
—
—
0
0
30
215
1.41
0.98
1.5
1.4
—
—
—
0
0
44
565
0.77
0.94
2.2
1.8
—
—
—
0
0
30
218
1.39
0.92
1.7
1.7
—
—
—
0
0
14
86
1.64
0.91
1.4
1.1
0.1
1.7
u/ml
—
6
32
16
102
1.58
0.91
1.1
1.1
—
—
—
0
0
754
7319
1.13
0.88
5.7
6.0
39.2
40.3
mmol/mol
3.64
703
6705
13
79
1.65
0.88
2.3
2.8
—
—
—
0
0
13
79
1.65
0.88
1.1
1.3
584.8
181643.2
e6/l
—
5
57
8
43
1.87
0.87
1.3
1.5
—
—
—
0
0
8
43
1.87
0.87
1.3
1.5
—
—
—
0
0
8
43
1.87
0.87
1.3
1.5
—
—
—
0
0
8
43
1.87
0.87
1.3
1.5
—
—
—
0
0
11
64
1.73
0.86
1.2
1.2
15.8
10.6
u/l
0.64
11
56
16
104
1.55
0.85
1.2
1.3
52208.4
79094.5
e6/l
—
8
64
44
345
1.29
0.84
1.0
1.0
—
—
—
0
0
8
45
1.78
0.84
1.3
1.1
—
—
—
0
0
58
475
1.23
0.79
1.1
1.2
170.6
148.3
iu/ml
0.11
19
186
0
24
0.00
0.79
0.0
1.9
—
8.5
—
0
13
15
98
1.54
0.78
2.3
2.6
37.7
26.2
mg/l
—
6
23
30
226
1.34
0.77
1.5
1.5
—
—
—
0
0
16
107
1.50
0.76
1.3
1.4
—
—
—
0
0
25
183
1.38
0.76
1.7
1.7
—
—
—
0
0
24
175
1.38
0.75
1.7
1.7
—
—
—
0
0
22
160
1.38
0.70
1.3
1.3
81.5
218.5
miu/ml
3.61
11
73
9
58
1.56
0.70
1.0
1.1
—
233.3
—
0
9
19
135
1.42
0.69
1.7
1.8
—
—
—
0
0
230
2125
1.11
0.67
1.6
1.6
1.3
1.4
mmol/l
1.50
195
1755
5
28
1.79
0.66
1.0
1.1
—
83.4
—
0
5
27
208
1.31
0.62
2.4
1.7
—
—
—
0
0
5
30
1.67
0.61
1.2
1.8
20.7
8.3
nmol/l
—
5
22
27
209
1.30
0.61
3.1
2.6
3.3
3.7
g/l
0.87
27
199
16
114
1.41
0.59
1.1
1.5
—
—
—
0
0
10
65
1.54
0.55
2.1
1.8
—
—
—
0
0
15
107
1.41
0.55
1.5
1.6
—
—
—
0
0
6
38
1.58
0.54
6.8
2.9
420.2
1720.8
u/ml
—
6
38
9
61
1.48
0.53
1.8
1.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
39
1.54
0.53
1.0
1.2
—
—
—
0
0
6
39
1.54
0.53
1.0
1.3
4.7
11.8
u/l
—
6
28
26
205
1.28
0.53
1.7
1.5
—
—
—
0
0
756
7408
1.09
0.52
17.2
13.6
77.1
77.5
ml/min/173m2
0.20
626
6075
10
146
0.68
0.52
1.1
1.2
11.7
37.0
u/l
—
10
129
6
97
0.62
0.52
1.8
1.5
—
—
—
0
0
6
40
1.50
0.51
2.5
1.8
—
—
—
0
0
85
755
1.14
0.51
2.5
2.1
0.2
0.2
g/l
0.02
77
706
111
1003
1.12
0.51
4.4
4.5
32.3
32.8
%
0.24
75
646
27
216
1.26
0.50
1.2
1.3
—
—
—
0
0
11
153
0.72
0.45
1.6
1.5
—
—
—
0
0
14
103
1.36
0.45
1.4
1.3
0.7
0.6
nmol/l
0.12
14
95
7
50
1.40
0.45
1.0
1.2
—
—
—
0
0
7
50
1.40
0.45
1.0
1.2
—
—
—
0
0
22
175
1.26
0.43
1.5
1.4
—
—
—
0
0
5
31
1.62
0.43
1.4
1.3
—
—
—
0
0
6
93
0.64
0.42
2.8
1.8
—
—
—
0
0
17
131
1.30
0.42
1.5
1.5
—
—
—
0
0
5
32
1.57
0.42
1.2
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
8
61
1.31
0.39
1.0
1.2
—
—
—
0
0
5
36
1.39
0.38
1.0
1.3
5.8
6.6
mmol/l
—
5
36
19
152
1.25
0.37
1.1
1.1
—
—
—
0
0
16
125
1.28
0.37
1.3
2.1
14605.7
4303.3
u/l
—
6
47
76
688
1.11
0.37
2.3
2.5
66.2
66.5
g/l
0.18
69
636
29
245
1.19
0.35
1.4
2.0
—
—
—
0
0
250
2616
0.94
0.35
3.3
4.0
9.3
8.0
mg/mmol
0.17
143
1641
32
274
1.17
0.34
1.4
1.2
0.2
1.5
u/ml
—
5
19
6
45
1.34
0.33
5.5
3.0
—
—
—
0
0
52
464
1.13
0.33
1.8
2.1
12.0
13.1
nmol/l
0.47
44
409
6
90
0.66
0.33
1.7
1.4
—
—
—
0
0
6
90
0.66
0.33
1.7
1.4
—
—
—
0
0
6
90
0.66
0.33
1.7
1.4
—
—
—
0
0
7
53
1.32
0.31
1.0
1.0
—
—
—
0
0
7
100
0.70
0.30
1.1
1.7
—
—
—
0
0
246
2562
0.95
0.30
3.0
3.1
6.6
7.3
mmol/l
2.21
209
2129
13
102
1.28
0.30
1.2
1.5
—
—
—
0
0
8
107
0.75
0.29
1.0
1.0
—
—
—
0
0
15
184
0.81
0.28
1.3
1.5
230.4
285.8
mu/l
1.01
15
165
55
498
1.11
0.28
4.7
3.4
1.5
1.8
mmol/l
0.37
48
384
10
76
1.32
0.28
1.1
1.6
—
—
—
0
0
13
161
0.80
0.27
3.2
3.4
59.5
58.2
%
0.15
13
161
46
509
0.90
0.26
1.7
1.9
—
—
—
0
0
18
214
0.84
0.26
3.1
2.2
87.8
99.8
ug/min
0.09
12
124
10
77
1.30
0.26
1.0
1.1
—
—
—
0
0
58
531
1.10
0.25
4.7
3.4
5.0
5.2
kpa
0.78
53
488
74
688
1.08
0.24
3.2
2.1
377.2
371.7
nmol/l
0.07
66
632
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
5
38
1.32
0.23
1.2
1.4
—
—
—
0
0
20
232
0.86
0.23
3.0
2.0
0.0
0.0
g/l
0.00
20
215
5
39
1.28
0.23
1.0
1.2
—
—
—
0
0
30
266
1.13
0.23
2.7
1.7
5.1
3.0
mg/l
0.33
16
204
15
125
1.20
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
6.6
—
—
—
0
0
20
230
0.87
0.21
3.0
2.0
0.0
0.0
g/l
0.00
20
214
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
49
1.23
0.20
1.3
1.2
—
—
—
0
0
6
51
1.18
0.19
1.5
1.2
—
—
—
0
0
6
51
1.18
0.19
1.5
1.2
—
—
—
0
0
13
154
0.84
0.19
3.2
3.1
4.5
4.3
e9/l
0.11
13
154
7
58
1.21
0.18
1.0
1.1
—
—
—
0
0
7
58
1.21
0.18
1.0
1.1
—
—
—
0
0
7
59
1.19
0.18
1.0
1.1
—
—
—
0
0
7
59
1.19
0.18
1.0
1.1
—
—
—
0
0
7
59
1.19
0.18
1.0
1.1
—
—
—
0
0
7
61
1.15
0.17
3.1
1.5
0.9
1.0
g/l
—
7
61
20
176
1.14
0.17
1.5
1.3
—
—
—
0
0
20
176
1.14
0.17
1.5
1.3
—
—
—
0
0
7
62
1.13
0.17
1.0
1.0
—
—
—
0
0
42
454
0.92
0.17
1.6
1.8
—
—
—
0
0
10
82
1.22
0.17
1.0
1.1
—
—
—
0
0
153
1477
1.04
0.16
3.2
3.1
0.9
0.8
ug/l
0.13
106
1016
6
77
0.78
0.15
1.2
1.4
—
—
—
0
0
22
245
0.90
0.15
2.9
2.0
0.0
0.0
g/l
0.50
22
228
28
306
0.91
0.14
2.9
2.0
2.8
3.1
g/l
0.50
20
245
20
180
1.11
0.13
1.5
1.4
—
—
—
0
0
35
374
0.93
0.11
1.4
1.3
—
—
—
0
0
22
201
1.10
0.11
1.2
1.2
—
—
—
0
0
5
45
1.11
0.10
1.4
1.8
—
—
—
0
0
113
1099
1.03
0.09
1.6
1.4
—
—
—
0
0
21
196
1.07
0.07
1.0
1.2
608.5
480.0
mg/l
0.20
21
182
41
393
1.05
0.07
2.5
3.3
26.6
63.0
u/ml
1.67
41
380
22
234
0.94
0.06
1.3
1.4
—
—
—
0
0
9
105
0.86
0.06
2.6
2.2
5.0
44.3
u/ml
—
9
98
20
188
1.07
0.05
1.4
1.7
—
—
—
0
0
12
129
0.93
0.03
1.1
1.1
—
—
—
0
0
14
133
1.05
0.01
1.3
1.2
—
—
—
0
0
10
106
0.94
0.01
2.1
1.3
—
—
—
0
0
10
106
0.94
0.01
2.1
1.3
—
—
—
0
0
10
106
0.94
0.01
2.1
1.3
—
—
—
0
0
12
114
1.05
0.00
1.8
1.7
—
—
—
0
0
32
326
0.98
0.00
2.7
1.9
3.6
3.8
g/l
0.24
20
241
32
326
0.98
0.00
2.7
1.9
7.2
7.5
g/l
0.22
21
252
32
326
0.98
0.00
2.7
1.9
—
—
—
0
0
10
104
0.96
0.00
2.1
1.4
—
—
—
0
0
10
104
0.96
0.00
2.1
1.4
—
—
—
0
0
17
174
0.98
0.00
1.4
2.6
17.9
15.7
%
—
8
91
24
244
0.98
0.00
1.1
1.1
—
—
—
0
0
32
316
1.01
0.00
5.9
3.8
24.4
24.8
mmol/l
0.42
32
297
11
112
0.98
0.00
5.7
4.7
377.5
369.2
umol/l
0.09
11
99
24
242
0.99
0.00
1.1
1.1
—
—
—
0
0
30
301
1.00
0.00
2.6
1.9
10.0
10.6
g/l
0.28
24
262
24
237
1.01
0.00
1.5
1.7
—
—
—
0
0
25
249
1.00
0.00
1.3
1.2
—
—
—
0
0
10
105
0.95
0.00
2.1
1.4
—
—
—
0
0
10
95
1.05
0.00
4.3
3.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
0.00
1.1
1.2
1.6
1.5
nmol/l
—
7
59
5
59
0.85
0.00
1.0
1.0
323.8
286.1
mg/l
—
5
51
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
76.8
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
51
0.98
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
29.0
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
7
75
0.93
0.00
1.1
1.1
—
—
—
0
0
7
71
0.99
0.00
1.7
2.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint HERING_UNILATERAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| HERING_UNILATERAL | 1.295 [1.16, 1.44] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.062 |
During the follow-up period (1.1.1998 — 31.12.2019), 1286 out of 4333 females with HERING_UNILATERAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| HERING_UNILATERAL | 1.073 [0.95, 1.21] | 0.246 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 809 out of 2808 males with HERING_UNILATERAL died.
Mortality risk
Mortality risk for people of age
years, who have HERING_UNILATERAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.119% | 0.186% |
| 5 | 0.747% | 1.151% |
| 10 | 1.797% | 3.065% |
| 15 | 3.311% | 5.71% |
| 20 | 5.777% | 9.605% |
Relationships between endpoints
↥Index endpoint: HERING_UNILATERAL – Inguinal hernia, unilateral
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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