Mononeuritis multiplex

G6_MONNEURMPLX

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G58.7
  • Hospital discharge: ICD-9 3545
  • Cause of death: ICD-10 G58.7
  • Cause of death: ICD-9 3545

2 out of 7 registries used, show all original rules.

104

4. Check minimum number of events

None

104

5. Include endpoints

None

104

6. Filter based on genotype QC (FinnGen only)

102

Control definitions (FinnGen only)

Control exclude
G6_NERPLEX

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G58
Name in latin
Mononeuropathia multiplex

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 592 287 300
Only index persons 504 254 250
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 54.09 53.93 54.18
Only index persons 52.78 52.21 53.36

-FinnGen-

Key figures

All Female Male
Number of individuals 102 48 54
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 55.17 53.24 56.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
104
Matched controls
1040
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G58.7
ICD-10 Finland
Mononeuritis multiplex
3651.7
104.3
83
*
N03AX16
ATC
[U] pregabalin
9.0
28.8
55
115
3545A
ICD-9 Finland
Mononeuritis of upper limb and mononeuritis multiplex, Mononeuritis multiplex
+∞
22.7
21
*
N03AX12
ATC
[U] gabapentin; oral
6.6
17.9
38
84
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
21.2
17.7
26
16
G56.0
ICD-10 Finland
Carpal tunnel syndrome
21.4
12.6
18
10
N06AX21
ATC
duloxetine; oral
6.9
12.6
22
39
ACC51
NOMESCO Finland
Release of median nerve
+∞
11.7
11
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.9
10.8
22
45
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
121.8
10.6
11
*
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
121.8
10.6
11
*
N02AX02
ATC
tramadol; systemic, rectal
3.3
8.4
57
278
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.2
7.5
17
38
G56.2
ICD-10 Finland
Lesion of ulnar nerve
+∞
7.4
7
*
L28
ICPC
Limited function/disability (L)
3.5
6.9
28
98
R20.2
ICD-10 Finland
Paraesthesia of skin
7.1
6.8
16
26
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
74.2
6.5
7
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
6.5
32
126
TAB00
NOMESCO Finland
Lumbar puncture
7.9
6.5
14
20
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
12.1
6.5
11
10
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
30
48
8.38
19.22
1.8
2.8
—
—
—
0
0
30
60
6.62
15.42
3.9
2.7
8.37
10.31
g/l
1.35
25
51
35
85
5.70
14.62
1.3
1.3
464.00
545.26
titre
—
5
19
20
18
13.45
11.66
1.9
1.6
1.08
1.24
g/l
0.94
20
18
19
18
12.63
10.82
1.8
1.6
0.21
0.24
g/l
0.42
19
18
17
16
12.44
9.71
1.5
1.1
—
—
—
0
0
12
5
26.82
9.14
1.7
1.0
—
—
—
0
0
16
22
8.38
7.53
1.4
1.1
429.80
2.65
e6/l
—
10
17
15
19
9.02
7.41
1.7
1.3
—
—
—
0
0
28
96
3.62
7.10
1.7
1.6
—
—
—
0
0
19
52
4.25
6.55
1.4
1.4
—
—
—
0
0
10
7
15.61
6.54
2.2
1.4
—
—
—
0
0
29
110
3.27
6.23
1.9
1.8
—
—
—
0
0
64
390
2.67
5.53
10.1
5.4
0.63
0.58
e9/l
0.93
57
337
64
391
2.66
5.48
10.1
5.4
0.05
0.04
e9/l
1.67
57
340
65
401
2.66
5.44
10.1
5.5
1.83
2.14
e9/l
0.48
56
357
22
77
3.36
5.32
1.5
1.5
—
—
—
0
0
65
406
2.60
5.23
10.3
5.6
0.22
0.19
e9/l
0.56
58
356
8
6
14.28
5.17
1.9
1.2
—
—
—
0
0
48
265
2.51
4.95
2.8
3.1
2.34
2.35
mmol/l
0.20
41
232
42
218
2.55
4.93
5.8
4.2
—
—
—
0
0
59
365
2.42
4.67
11.1
6.1
—
—
—
0
0
7
5
14.86
4.64
1.0
1.0
—
—
—
0
0
9
13
7.46
4.26
1.4
1.2
—
—
—
0
0
68
474
2.26
3.76
13.8
9.7
3.94
3.98
e9/l
0.05
61
415
55
353
2.18
3.73
5.1
4.1
35.55
35.45
g/l
0.03
50
339
30
150
2.41
3.68
2.4
1.4
1.74
2.59
g/l
2.27
23
94
79
597
2.34
3.44
7.2
3.9
13.36
12.71
mm/h
0.11
73
541
24
113
2.46
3.33
2.3
1.8
—
—
—
0
0
6
7
9.00
3.30
1.0
1.1
—
—
—
0
0
31
166
2.24
3.22
1.9
1.5
964.95
1298.35
nmol/l
1.69
24
130
43
263
2.08
3.19
2.9
2.4
—
—
—
0
0
51
337
2.01
3.03
2.4
1.8
92.74
93.79
pmol/l
0.06
32
162
8
17
5.00
2.98
1.0
1.1
—
—
—
0
0
58
408
1.95
2.81
7.8
6.5
1.21
1.21
mmol/l
0.00
51
356
5
6
8.67
2.78
1.4
1.0
—
—
—
0
0
19
90
2.36
2.58
3.1
1.5
—
—
—
0
0
6
11
5.71
2.58
1.8
1.5
—
—
—
0
0
6
11
5.71
2.58
2.2
3.0
—
—
—
0
0
5
7
7.43
2.57
3.6
2.6
58.20
31.23
%
—
5
7
7
16
4.61
2.52
1.7
3.9
—
—
—
0
0
50
344
1.87
2.51
4.3
3.6
30.44
44.15
ng/l
0.55
39
245
18
85
2.35
2.46
4.8
3.9
—
—
—
0
0
14
61
2.50
2.26
6.7
3.9
0.50
0.62
%
—
6
17
5
9
5.77
2.24
1.0
1.2
—
—
—
0
0
13
55
2.56
2.22
2.1
1.6
—
—
—
0
0
72
570
1.86
2.19
7.3
3.8
—
—
—
0
0
5
10
5.19
2.09
1.2
1.6
—
—
—
0
0
14
66
2.30
1.92
8.0
3.9
0.00
0.11
%
—
6
19
6
17
3.68
1.86
2.0
1.8
—
—
—
0
0
15
75
2.17
1.80
1.7
1.6
—
—
—
0
0
14
68
2.22
1.80
7.9
3.7
0.00
0.05
%
—
6
20
5
13
3.98
1.73
2.2
1.2
—
—
—
0
0
55
424
1.63
1.65
15.7
13.9
1.14
1.28
inr
0.73
16
120
88
769
1.94
1.64
5.4
4.3
1.73
1.94
mu/l
1.00
83
691
35
243
1.66
1.57
3.1
2.7
—
—
—
0
0
20
118
1.86
1.55
1.3
1.3
9.80
27.93
iu/ml
—
5
45
13
66
2.11
1.51
1.5
1.3
—
—
—
0
0
14
74
2.03
1.47
8.3
3.8
0.67
1.17
%
—
6
27
9
39
2.43
1.47
1.7
1.2
220.61
170.56
u/ml
—
9
34
13
67
2.07
1.46
9.3
5.3
14.86
9.88
mmol/l
1.22
13
61
32
221
1.65
1.45
6.8
6.8
—
—
—
0
0
5
16
3.23
1.45
2.4
1.8
—
—
—
0
0
34
240
1.62
1.42
4.1
4.1
—
—
—
0
0
29
198
1.64
1.37
2.0
1.8
2.57
3.22
mg/l
1.05
24
171
18
108
1.81
1.33
4.6
8.0
103.78
103.76
mmol/l
0.01
18
108
18
110
1.77
1.25
1.3
1.3
1.30
9.30
u/ml
—
8
47
71
605
1.55
1.23
5.0
3.5
14.90
14.92
pmol/l
0.02
66
544
31
221
1.57
1.22
5.2
3.0
—
—
—
0
0
15
88
1.82
1.19
1.2
1.3
—
—
—
0
0
36
268
1.53
1.17
3.2
3.0
6.96
7.42
mmol/l
0.30
30
231
23
155
1.62
1.14
2.7
3.2
1431.76
177.88
ng/l
0.42
17
123
7
31
2.35
1.13
1.1
1.5
—
—
—
0
0
7
33
2.20
1.08
5.6
3.0
23.71
24.14
mmol/l
—
7
33
9
46
2.05
1.07
3.0
2.5
—
—
—
0
0
17
109
1.67
1.01
1.4
1.2
—
—
—
0
0
50
409
1.43
0.99
4.7
3.4
0.00
0.00
estimate
-0.00
15
79
34
259
1.46
0.98
2.8
3.1
2653.18
68.05
mg/l
0.48
18
168
31
232
1.48
0.97
5.4
3.6
0.00
0.00
estimate
-0.00
14
70
10
55
1.91
0.96
4.2
10.7
0.79
0.75
%
—
10
55
10
55
1.91
0.96
4.2
10.7
1.93
1.36
%
—
10
55
16
105
1.62
0.88
1.4
1.5
—
—
—
0
0
44
359
1.39
0.86
14.5
9.5
0.00
0.01
e9/l
0.53
38
296
32
249
1.41
0.81
6.6
4.0
7.40
7.40
ph
—
6
44
91
847
1.60
0.79
25.0
13.2
22.37
24.48
mg/l
0.26
83
652
36
288
1.38
0.78
5.9
3.5
48.53
62.67
e6/l
0.17
26
207
49
413
1.35
0.76
6.2
4.5
0.00
0.00
estimate
-0.00
14
75
26
197
1.43
0.76
1.5
1.5
17.01
21.12
nmol/l
1.06
21
161
22
288
0.70
0.72
3.0
2.9
—
—
—
0
0
49
417
1.33
0.70
4.8
3.5
0.00
0.00
estimate
-0.00
15
70
7
43
1.67
0.68
5.9
7.6
23.60
25.17
mmol/l
—
7
43
29
229
1.37
0.67
1.6
1.3
—
—
—
0
0
28
220
1.37
0.67
5.0
2.9
—
—
—
0
0
5
29
1.76
0.64
1.4
3.9
3.86
3.94
mmol/l
—
5
29
5
29
1.76
0.64
3.8
3.6
—
—
—
0
0
10
64
1.62
0.61
7.1
3.5
—
—
—
0
0
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
11
74
1.54
0.56
2.5
3.2
—
—
—
0
0
14
101
1.45
0.53
2.1
1.3
—
—
—
0
0
28
229
1.30
0.51
4.9
2.9
0.58
0.28
e6/l
0.54
22
172
30
249
1.29
0.49
5.1
3.0
20.61
315.31
e6/l
0.59
24
190
93
889
1.44
0.47
24.5
15.5
139.58
139.59
mmol/l
0.01
93
866
88
835
1.35
0.46
5.4
4.6
5.98
6.02
mmol/l
0.14
83
768
33
280
1.26
0.46
3.9
3.7
5.69
9.39
mg/mmol
0.55
17
169
0
16
0.00
0.41
0.0
2.8
—
60.25
—
0
16
0
16
0.00
0.41
0.0
3.6
—
—
—
0
0
39
341
1.23
0.41
2.6
2.0
—
—
—
0
0
93
894
1.38
0.39
25.0
15.5
3.99
3.98
mmol/l
0.09
93
872
5
36
1.41
0.38
1.2
1.1
—
—
—
0
0
9
70
1.31
0.38
8.2
9.1
—
—
—
0
0
23
192
1.25
0.36
3.2
3.6
—
—
—
0
0
10
73
1.41
0.36
2.1
2.1
110.70
116.50
ng/l
—
10
68
11
83
1.36
0.33
3.2
2.0
0.18
0.21
g/l
0.52
11
75
7
52
1.37
0.32
1.1
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
10
80
1.28
0.21
1.6
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
6
49
1.24
0.20
1.2
1.2
—
—
—
0
0
18
203
0.86
0.17
3.1
2.9
0.53
0.74
ug/l
1.08
13
140
93
945
0.85
0.12
36.6
20.2
133.98
135.63
g/l
0.44
93
930
93
945
0.85
0.12
36.5
20.2
6.93
6.71
e9/l
0.47
93
917
93
945
0.85
0.12
36.5
20.2
4.45
4.48
e12/l
0.22
93
917
93
914
1.17
0.12
28.9
16.1
86.41
78.42
umol/l
0.84
93
914
93
944
0.86
0.11
36.3
20.1
91.32
91.40
fl
0.07
93
930
93
944
0.86
0.11
36.2
20.1
30.30
30.44
pg
0.31
93
930
20
184
1.11
0.10
2.3
1.7
429.65
479.52
pmol/l
0.45
20
157
70
718
0.92
0.10
29.0
16.3
16.02
15.28
%
0.40
70
709
83
846
0.91
0.10
4.7
4.6
4.36
4.63
mmol/l
1.87
76
787
93
943
0.87
0.09
36.5
20.2
249.43
245.99
e9/l
0.22
93
919
6
57
1.06
0.08
1.7
3.8
—
—
—
0
0
6
71
0.84
0.08
1.3
1.4
—
—
—
0
0
8
91
0.87
0.07
1.6
1.2
—
—
—
0
0
61
599
1.04
0.04
4.5
3.9
—
—
—
0
0
83
820
1.06
0.04
4.2
4.0
1.33
1.27
mmol/l
0.37
75
756
88
888
0.94
0.02
22.0
13.0
—
—
—
0
0
85
844
1.04
0.00
4.6
4.5
1.43
1.46
mmol/l
0.26
79
780
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
0.26
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1694.50
—
0
6
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.1
—
69.29
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.87
-0.00
2.2
3.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_MONNEURMPLX and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_MONNEURMPLX.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: G6_MONNEURMPLX – Mononeuritis multiplex

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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