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Mononeuritis multiplex

DOID EFO Endpoint Browser PheWeb

G6_MONNEURMPLX

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G58.7
  • Hospital discharge: ICD-9 — 3545
  • Cause of death: ICD-10 — G58.7
  • Cause of death: ICD-9 — 3545

2 out of 7 registries used, show all original rules.

101

4. Check minimum number of events

None

101

5. Include endpoints

None

101

6. Filter based on genotype QC (FinnGen only)

101

Control definitions (FinnGen only)

Control exclude
G6_NERPLEX

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G58
Name in latin
Mononeuropathia multiplex

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 592 287 300
Only index persons 504 254 250
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 54.09 53.93 54.18
Only index persons 52.78 52.21 53.36

-FinnGen-

Key figures

All Female Male
Number of individuals 101 49 52
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 55.56 53.05 57.93

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
87
Matched controls
868
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G58.7
ICD-10 Finland
Mononeuritis multiplex
+∞
86.4
68
*
3545A
ICD-9 Finland
Mononeuritis of upper limb and mononeuritis multiplex, Mononeuritis multiplex
+∞
20.6
19
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
34.1
18.0
23
9
N03AX16
ATC
pregabalin; oral
8.1
15.8
42
90
G56.0
ICD-10 Finland
Carpal tunnel syndrome
59.6
13.3
15
*
N03AX12
ATC
gabapentin; oral
7.3
11.9
31
61
ACC51
NOMESCO Finland
Release of median nerve
+∞
9.5
9
*
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
+∞
9.5
9
*
TAB00
NOMESCO Finland
Lumbar puncture
15.2
7.6
12
9
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
+∞
7.4
7
*
G56.2
ICD-10 Finland
Lesion of ulnar nerve
+∞
7.4
7
*
R20.2
ICD-10 Finland
Paraesthesia of skin
10.0
6.8
13
15
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
+∞
6.3
6
*

Mortality – FinRegistry

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Association

Association between endpoint G6_MONNEURMPLX and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have G6_MONNEURMPLX.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

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Index endpoint: G6_MONNEURMPLX – Mononeuritis multiplex

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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