≡ Risteys
FG R12 + FR

Documentation Changelog GitHub Contact & Feedback

Liver disorders in diseases classified elsewhere

DOID EFO Endpoint Browser PheWeb

K11_LIVDISINOTH

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

103

4. Check minimum number of events

None

103

5. Include endpoints

None

103

6. Filter based on genotype QC (FinnGen only)

103

Control definitions (FinnGen only)

Control exclude
K11_LIVER

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 658 357 293
Only index persons 589 326 263
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 41.72 45.97 36.16
Only index persons 40.95 45.13 35.77

-FinnGen-

Key figures

All Female Male
Number of individuals 103 68 35
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 47.02 46.22 48.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
93
Matched controls
928
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K77.0*B25.1
ICD-10 Finland
Cytomegaloviral hepatitis
+∞
54.7
47
*
K77.8*D86.8
ICD-10 Finland
Hepatic granulomas in sarcoidosis
+∞
24.0
22
*
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
+∞
19.4
18
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
41.8
16.5
20
6
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
10.5
15.1
31
42
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
176.6
14.9
15
*
K76.9
ICD-10 Finland
Liver disease, unspecified
+∞
13.9
13
*
A05AA02
ATC
ursodeoxycholic acid; oral
58.9
13.3
15
*
K77.8
ICD-10 Finland
Liver disorders in other diseases classified elsewhere
+∞
12.8
12
*
R50.9
ICD-10 Finland
Fever, unspecified
6.9
12.2
33
68
K77.0
ICD-10 Finland
Liver disorders in infectious and parasitic diseases classified elsewhere
+∞
11.7
11
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.7
11.3
57
235
L04AA06
ATC
mycophenolic acid; systemic
29.8
10.1
13
5
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
+∞
8.5
8
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.7
8.2
24
53
D86.0
ICD-10 Finland
Sarcoidosis of lung
49.3
7.9
9
*
Z94.4
ICD-10 Finland
Liver transplant status
+∞
7.4
7
*
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
43.3
6.9
8
*
127
Kela drug reimbursment
Transplant complication
24.6
6.8
9
*
TK800
NOMESCO Finland
Hemodialysis
24.6
6.8
9
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
10.4
6.5
12
13
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.0
6.5
14
20
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
30
17
24.49
38.33
1.1
1.3
553.1
136.2
u/ml
—
9
11
30
18
23.11
37.33
1.2
1.3
—
—
—
0
0
25
11
29.69
35.16
1.1
1.2
—
—
—
0
0
33
30
15.71
32.84
1.3
1.3
—
—
—
0
0
41
54
11.95
31.83
1.6
1.7
2.1
1.0
g/l
3.40
35
49
24
8
38.46
19.38
1.2
1.1
—
—
—
0
0
39
92
6.21
17.07
3.8
2.0
22.0
24.3
%
0.42
33
78
36
79
6.47
16.99
8.5
1.8
12.5
7.0
umol/l
0.84
31
67
44
121
5.60
16.16
1.8
1.5
461.5
594.8
titre
0.27
13
31
38
98
5.56
14.88
3.7
2.0
2.4
2.4
g/l
0.14
32
89
43
124
5.24
14.78
2.0
1.5
—
—
—
0
0
66
270
5.02
14.59
13.2
5.2
—
—
—
0
0
53
201
4.37
12.50
3.5
2.7
0.2
0.4
e6/l
0.98
41
142
82
434
5.36
12.15
12.8
5.5
0.6
0.6
e9/l
0.67
76
386
82
434
5.36
12.15
12.9
5.6
0.0
0.0
e9/l
0.26
76
388
30
74
5.31
12.14
1.5
1.6
—
—
—
0
0
63
279
4.24
11.81
12.4
6.0
1.0
1.1
inr
2.13
17
78
52
204
4.13
11.52
3.5
2.5
—
—
—
0
0
82
448
5.07
11.29
14.4
6.1
0.2
0.2
e9/l
0.33
77
404
53
218
3.95
10.83
11.8
3.8
7.4
7.4
ph
—
10
35
47
178
4.02
10.82
7.2
3.7
—
—
—
0
0
45
167
4.01
10.64
1.8
1.7
—
—
—
0
0
54
229
3.85
10.47
3.5
2.7
148.6
343.1
e6/l
0.26
43
171
60
274
3.85
10.40
4.7
3.3
41.6
35.0
e6/l
0.10
45
186
13
16
9.15
9.96
6.4
2.7
1.9
1.3
mg/l
1.63
13
16
13
7
20.97
9.20
1.2
1.4
—
—
—
0
0
42
163
3.66
9.08
2.3
1.9
2.5
3.0
mg/l
0.76
35
147
23
58
4.82
8.90
14.3
5.8
—
—
—
0
0
39
148
3.63
8.67
2.0
2.3
6.3
5.0
e6/l
0.26
32
134
68
367
3.51
8.55
18.7
8.1
0.0
0.0
e9/l
0.44
59
292
22
59
4.47
7.85
6.4
3.4
—
—
—
0
0
48
221
3.19
7.66
15.9
6.9
—
—
—
0
0
34
129
3.44
7.42
2.1
2.2
433.0
580.0
mosm/kgh2o
2.71
27
115
7
0
+∞
7.37
2.9
0.0
—
—
—
0
0
67
381
3.17
7.29
4.8
2.6
171.4
90.7
ug/l
1.02
59
352
10
14
7.80
6.82
1.3
1.4
—
—
—
0
0
17
43
4.54
6.46
2.1
2.0
—
—
—
0
0
44
212
2.88
6.24
1.8
1.4
2.5
2.5
g/l
0.01
36
133
16
41
4.44
5.97
12.3
5.4
24.7
25.0
mmol/l
0.08
16
41
15
37
4.57
5.86
14.5
7.5
95.3
92.1
%
0.95
15
37
41
200
2.74
5.57
2.1
2.1
—
—
—
0
0
21
72
3.41
5.24
11.2
6.9
0.3
1.5
mmol/l
0.76
16
57
79
547
2.91
5.14
6.3
3.9
—
351.0
—
0
10
9
10
9.72
4.89
1.2
1.1
—
—
—
0
0
18
59
3.49
4.79
4.8
4.6
1.0
0.4
%
—
5
15
19
65
3.36
4.74
5.5
4.6
0.3
0.8
%
—
7
22
80
570
2.81
4.70
6.8
3.8
—
—
—
0
0
64
418
2.40
4.41
5.7
3.4
0.0
0.0
estimate
0.00
13
72
63
411
2.37
4.32
7.1
4.6
0.0
0.0
estimate
0.00
16
74
63
413
2.35
4.25
5.7
3.3
0.0
0.0
estimate
0.00
16
74
17
58
3.31
4.24
6.8
2.8
—
—
—
0
0
17
59
3.25
4.13
4.9
4.8
0.0
0.2
%
—
6
19
17
59
3.25
4.13
3.1
2.8
74.0
71.8
e9/l
—
10
48
40
218
2.36
4.11
3.5
2.6
—
—
—
0
0
19
72
3.01
4.00
1.3
1.4
—
—
—
0
0
45
262
2.27
3.94
4.3
2.1
63.9
55.2
u/l
1.00
40
248
52
322
2.24
3.92
4.8
3.3
—
—
—
0
0
12
34
3.86
3.90
1.9
1.4
—
—
—
0
0
8
12
7.12
3.75
1.0
1.4
—
—
—
0
0
8
12
7.12
3.75
2.0
2.9
—
—
—
0
0
16
57
3.14
3.72
4.9
4.6
0.0
0.0
%
—
5
16
34
180
2.33
3.68
5.3
3.7
—
—
—
0
0
39
229
2.13
3.23
4.2
2.8
5.4
7.9
mmol/l
4.31
31
197
11
34
3.50
3.16
13.1
6.4
—
—
—
0
0
19
83
2.58
3.06
2.2
1.5
—
—
—
0
0
36
209
2.11
3.05
9.2
4.8
—
—
—
0
0
24
120
2.30
2.91
2.6
1.9
—
—
—
0
0
11
37
3.21
2.78
1.0
1.4
—
—
—
0
0
12
43
3.03
2.75
1.0
1.3
—
—
—
0
0
14
55
2.79
2.75
1.5
2.5
—
—
—
0
0
6
10
6.29
2.73
3.7
1.4
—
—
—
0
0
33
193
2.04
2.70
4.5
3.1
62.1
56.7
mg/l
0.05
18
121
12
44
2.96
2.65
1.0
1.3
—
—
—
0
0
12
44
2.96
2.65
1.1
1.3
—
—
—
0
0
12
44
2.96
2.65
1.0
1.3
—
—
—
0
0
6
11
5.71
2.58
4.7
2.8
3.3
4.0
e9/l
—
6
11
6
11
5.71
2.58
4.7
4.2
53.7
60.9
%
—
6
11
5
7
7.43
2.57
1.6
2.0
—
—
—
0
0
5
7
7.43
2.57
1.6
2.0
—
—
—
0
0
5
7
7.43
2.57
1.6
2.0
—
—
—
0
0
5
7
7.43
2.57
1.6
2.0
—
—
—
0
0
12
45
2.89
2.55
1.0
1.3
—
—
—
0
0
38
241
1.91
2.44
3.2
2.0
—
—
—
0
0
6
12
5.23
2.44
1.7
2.2
850.5
425.0
e6/l
—
6
7
6
12
5.23
2.44
1.0
3.9
—
—
—
0
0
5
8
6.50
2.40
1.0
1.4
—
—
—
0
0
10
35
3.06
2.38
2.8
1.3
0.3
0.2
g/l
—
10
35
33
202
1.93
2.34
5.5
3.8
10.7
10.2
mg/mmol
0.03
17
121
10
36
2.97
2.27
2.8
1.3
1.3
1.2
g/l
—
10
36
5
9
5.77
2.24
1.0
1.2
—
—
—
0
0
7
19
3.87
2.19
1.9
1.5
—
—
—
0
0
10
37
2.89
2.17
3.2
2.6
—
—
—
0
0
42
290
1.76
1.99
1.8
1.9
115.5
94.7
pmol/l
1.31
27
160
18
94
2.11
1.95
2.8
1.5
—
—
—
0
0
33
214
1.80
1.92
5.5
3.6
0.0
0.0
estimate
0.00
16
75
24
141
1.92
1.89
2.0
1.7
418.9
476.1
pmol/l
0.49
18
122
95
856
2.41
1.80
34.9
11.5
20.8
21.6
mg/l
0.08
88
645
33
222
1.72
1.68
1.6
1.3
0.7
0.9
u/ml
—
8
61
34
232
1.69
1.64
2.8
2.0
119.3
149.1
u/l
0.47
34
224
7
26
2.81
1.61
2.3
4.5
—
—
—
0
0
18
105
1.87
1.45
1.2
1.2
—
—
—
0
0
9
41
2.31
1.41
2.6
4.6
—
—
—
0
0
17
99
1.86
1.37
1.4
1.1
—
—
—
0
0
12
62
2.06
1.34
6.0
4.2
—
—
—
0
0
6
24
2.59
1.32
1.2
1.3
—
—
—
0
0
8
36
2.32
1.27
2.0
2.5
—
—
—
0
0
9
47
2.00
1.05
1.7
1.2
—
—
—
0
0
18
118
1.64
0.99
1.9
1.6
1828.4
1104.8
nmol/l
1.10
11
93
0
31
0.00
0.98
0.0
1.2
—
—
—
0
0
85
773
1.57
0.93
7.2
5.0
40.6
38.8
mmol/mol
0.75
78
728
32
243
1.46
0.93
4.7
2.7
—
—
—
0
0
24
172
1.52
0.92
1.3
1.3
20.8
17.7
iu/ml
—
10
52
75
667
1.46
0.90
5.2
4.2
14.6
14.7
pmol/l
0.03
67
618
30
227
1.45
0.89
2.2
1.7
1.6
1.3
mmol/l
0.91
24
198
12
73
1.73
0.86
7.0
4.4
—
—
—
0
0
32
247
1.43
0.85
1.8
1.5
—
—
—
0
0
8
46
1.80
0.85
1.1
1.1
—
—
—
0
0
15
100
1.59
0.78
1.8
1.5
—
—
—
0
0
28
354
0.71
0.76
3.3
2.5
—
—
—
0
0
5
25
2.05
0.73
5.2
2.6
—
—
—
0
0
13
85
1.61
0.73
1.5
1.1
—
—
—
0
0
5
26
1.97
0.71
1.8
2.4
—
—
—
0
0
87
809
1.49
0.70
36.4
11.8
37.8
40.5
%
1.83
72
652
5
28
1.82
0.67
1.4
1.6
—
—
—
0
0
6
104
0.55
0.66
2.8
2.6
0.5
0.7
ug/l
—
6
63
0
23
0.00
0.59
0.0
3.0
—
46.1
—
0
23
27
220
1.31
0.51
3.3
3.5
—
—
—
0
0
34
286
1.28
0.51
4.7
3.6
16.3
24.6
ng/l
1.21
22
165
21
165
1.34
0.50
1.3
1.2
14.4
8.4
u/ml
—
5
67
10
69
1.50
0.46
1.5
1.5
—
—
—
0
0
5
32
1.59
0.43
1.4
1.3
—
—
—
0
0
7
102
0.66
0.42
2.0
1.2
—
—
—
0
0
7
54
1.32
0.31
1.3
1.3
35.1
24.9
iu/l
—
7
49
5
37
1.37
0.24
1.4
2.5
0.9
1.4
%
—
5
37
40
367
1.15
0.23
2.1
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
12.3
—
793.3
—
0
11
0
11
0.00
0.21
0.0
21.8
—
1427.7
—
0
11
6
48
1.27
0.20
1.2
1.2
—
—
—
0
0
13
114
1.16
0.12
1.5
1.5
—
—
—
0
0
81
792
1.11
0.11
6.2
4.8
1.9
1.8
mu/l
0.19
73
742
13
116
1.14
0.10
2.2
1.8
—
—
—
0
0
5
60
0.82
0.08
2.4
1.7
—
—
—
0
0
60
585
1.06
0.07
4.6
3.3
—
—
—
0
0
9
104
0.85
0.06
1.8
1.8
—
—
—
0
0
84
829
1.07
0.05
4.3
3.6
1.3
1.3
mmol/l
0.03
75
774
88
871
1.07
0.03
5.3
4.4
2.7
2.9
mmol/l
0.86
83
815
86
853
1.05
0.01
4.9
4.0
1.4
1.5
mmol/l
1.54
81
797
10
106
0.94
0.01
1.6
1.3
—
—
—
0
0
83
826
1.02
0.00
5.0
4.1
6.2
5.8
mmol/l
0.95
78
772
86
859
1.01
0.00
5.0
4.1
4.7
4.8
mmol/l
0.52
80
807
92
921
0.99
0.00
25.3
10.6
—
—
—
0
0
5
49
1.02
0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
14.3
—
0
5
0
5
0.00
0.00
0.0
1.2
—
1.6
—
0
5
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
9.6
—
0.6
—
0
9
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
16.3
—
0
5
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
24.4
—
0
6
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint K11_LIVDISINOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_LIVDISINOTH.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: K11_LIVDISINOTH – Liver disorders in diseases classified elsewhere

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data