liver disease: A disease involving the liver.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
107 |
4. Check minimum number of eventsNone |
107 |
5. Include endpointsNone |
107 |
6. Filter based on genotype QC (FinnGen only) |
103 |
Control definitions (FinnGen only)
- Control exclude
- K11_LIVER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Liver disorders in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Diseases of liver
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 658 | 357 | 293 |
| Only index persons | 589 | 326 | 263 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 41.72 | 45.97 | 36.16 |
| Only index persons | 40.95 | 45.13 | 35.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 103 | 69 | 34 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 47.88 | 46.33 | 51.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 107
- Matched controls
- 1070
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K77.0*B25.1
ICD-10 Finland
Cytomegaloviral hepatitis
+∞
65.5
56
*
K77.8*D86.8
ICD-10 Finland
Hepatic granulomas in sarcoidosis
+∞
27.2
25
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
9.5
23.6
34
50
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
+∞
20.5
19
*
R50.9
ICD-10 Finland
Fever, unspecified
6.2
17.6
40
94
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
36.8
16.9
21
7
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.1
14.3
30
64
K76.9
ICD-10 Finland
Liver disease, unspecified
79.6
12.9
14
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.4
12.7
68
304
L04AA06
ATC
mycophenolic acid; systemic
53.1
12.2
14
*
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
26.5
12.0
16
7
A05AA02
ATC
ursodeoxycholic acid; oral
31.8
11.0
14
5
K77.0
ICD-10 Finland
Liver disorders in infectious and parasitic diseases classified elsewhere
+∞
10.6
10
*
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
+∞
9.5
9
*
JN4AD
NOMESCO Finland
Body CT examination
5.9
9.5
19
38
127
Kela drug reimbursment
Transplant complication
40.4
9.2
11
*
L04AD02
ATC
tacrolimus; systemic
97.4
8.5
9
*
M05BA04
ATC
alendronic acid; oral
10.7
8.1
15
16
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
9.5
7.6
15
18
Z94.4
ICD-10 Finland
Liver transplant status
85.8
7.5
8
*
K77.8
ICD-10 Finland
Liver disorders in other diseases classified elsewhere
+∞
7.4
7
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
7.4
7
*
TK800
NOMESCO Finland
Hemodialysis
21.8
7.3
10
5
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
12.1
7.0
12
11
D86.0
ICD-10 Finland
Sarcoidosis of lung
18.2
6.9
10
6
L04AX01
ATC
azathioprine; systemic
9.1
6.6
13
16
K83.0
ICD-10 Finland
Cholangitis
74.1
6.5
7
*
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
19.4
6.4
9
5
K77.0*B00.8
ICD-10 Finland
Herpesviral hepatitis
+∞
6.3
6
*
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
31
17
25.09
22.07
1.1
1.3
528.80
136.18
u/ml
—
10
11
31
18
23.68
21.67
1.1
1.3
—
—
—
0
0
38
82
6.64
18.29
8.1
1.8
12.03
6.89
umol/l
0.83
33
70
41
96
6.30
18.12
3.9
2.0
22.05
24.34
%
0.46
35
81
40
102
5.67
15.90
3.8
2.0
2.37
2.43
g/l
0.21
34
92
56
208
4.55
13.72
4.2
2.6
0.16
0.37
e6/l
1.01
44
149
65
275
4.47
13.24
4.8
2.9
—
—
—
0
0
15
7
24.58
11.03
1.3
1.4
—
—
—
0
0
21
25
10.16
10.67
1.4
1.3
—
—
—
0
0
69
352
3.70
9.79
14.5
10.4
1.03
1.19
inr
2.50
21
100
30
89
4.29
9.48
2.2
1.8
—
—
—
0
0
71
374
3.67
9.48
16.1
6.0
1.21
1.22
mmol/l
0.40
59
325
37
128
3.89
9.47
2.1
1.9
—
—
—
0
0
43
167
3.63
9.25
2.3
1.9
2.53
2.91
mg/l
0.70
36
151
13
7
20.87
9.19
1.1
1.3
—
—
—
0
0
71
395
3.37
8.27
4.8
2.6
169.73
90.35
ug/l
1.08
63
366
28
87
4.00
8.23
2.0
1.7
—
—
—
0
0
33
122
3.47
7.47
4.8
2.5
0.76
3.01
e6/l
1.34
22
65
34
129
3.40
7.38
4.7
2.4
0.41
1.06
e6/l
1.81
24
71
17
39
4.99
7.26
2.0
1.6
—
—
—
0
0
40
182
2.91
6.26
2.9
1.9
—
—
—
0
0
24
82
3.48
6.04
11.0
6.2
104.96
103.91
mmol/l
0.52
24
82
16
43
4.20
5.61
12.3
5.3
24.74
24.85
mmol/l
0.04
16
43
12
18
7.36
5.43
2.2
1.1
0.00
0.00
g/l
-0.00
12
18
12
18
7.36
5.43
2.2
1.1
0.00
0.00
g/l
-0.00
12
18
10
12
9.05
5.18
3.9
1.7
5.42
8.88
u/ml
—
10
12
20
67
3.44
5.15
2.7
2.9
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
10
13
8.35
4.97
2.5
2.9
0.19
0.52
u/ml
—
5
8
12
21
6.29
4.92
2.2
1.2
1.89
0.26
g/l
0.62
12
21
12
21
6.29
4.92
2.2
1.2
0.00
0.00
g/l
-0.00
12
21
13
26
5.54
4.81
2.2
1.2
—
—
—
0
0
21
76
3.19
4.78
11.2
7.1
0.27
1.48
mmol/l
0.75
16
63
66
428
2.41
4.63
6.2
3.4
0.00
0.00
estimate
-0.00
14
74
8
8
10.68
4.60
1.3
1.1
—
—
—
0
0
65
420
2.40
4.58
8.2
4.6
0.00
0.00
estimate
-0.00
17
76
65
422
2.38
4.51
6.2
3.3
0.00
0.00
estimate
-0.00
18
81
16
51
3.51
4.42
2.9
1.3
—
—
—
0
0
15
39
4.30
4.41
14.5
7.4
95.29
92.26
%
0.93
15
39
8
9
9.49
4.36
4.4
1.9
1312.25
789.78
u/ml
—
8
9
47
270
2.32
4.27
4.3
2.0
64.57
55.37
u/l
1.15
42
255
16
53
3.37
4.17
13.9
5.2
1.14
1.21
mmol/l
0.15
16
53
28
128
2.61
4.17
2.0
1.7
1.42
1.43
%
0.03
23
120
7
11
6.72
3.24
5.0
4.2
53.57
60.91
%
—
7
11
36
210
2.08
2.98
5.5
3.6
13.15
10.33
mg/mmol
0.17
20
127
7
13
5.68
2.92
1.6
1.0
—
—
—
0
0
5
6
8.66
2.78
1.2
1.0
—
—
—
0
0
10
29
3.69
2.77
1.5
1.4
—
—
—
0
0
11
35
3.38
2.74
3.4
1.3
0.25
0.24
g/l
0.14
11
35
8
19
4.46
2.73
1.4
1.9
—
—
—
0
0
6
10
6.28
2.73
1.0
1.2
—
—
—
0
0
6
10
6.28
2.73
1.7
2.5
—
—
—
0
0
11
36
3.29
2.65
3.4
1.3
1.30
1.18
g/l
0.63
11
36
8
20
4.23
2.62
2.6
1.1
—
—
—
0
0
8
21
4.03
2.52
2.4
2.6
—
—
—
0
0
6
12
5.22
2.43
1.7
2.2
850.50
425.00
e6/l
—
6
7
5
8
6.49
2.39
1.6
2.1
—
—
—
0
0
5
8
6.49
2.39
1.6
2.1
—
—
—
0
0
26
146
2.03
2.33
2.0
1.7
432.85
475.07
pmol/l
0.36
20
127
15
67
2.44
2.30
3.1
2.1
71.83
70.40
ml/min/173m2
—
6
30
7
18
4.08
2.29
1.4
2.0
—
—
—
0
0
44
301
1.78
2.16
1.8
1.9
115.52
94.92
pmol/l
1.29
27
163
7
20
3.67
2.09
1.4
1.3
—
—
—
0
0
99
889
2.52
2.07
35.2
11.5
20.59
21.28
mg/l
0.07
91
668
34
218
1.82
2.05
5.6
3.6
0.00
0.00
estimate
-0.00
17
77
9
32
2.97
2.05
1.4
1.1
—
—
—
0
0
5
11
4.71
1.96
1.6
1.5
—
—
—
0
0
6
17
3.67
1.86
2.5
1.9
—
—
—
0
0
8
29
2.90
1.83
1.5
1.9
—
—
—
0
0
9
36
2.63
1.78
6.1
1.7
—
—
—
0
0
6
18
3.47
1.77
2.7
1.3
—
—
—
0
0
8
30
2.80
1.76
1.0
1.1
—
4.84
—
0
5
5
13
3.98
1.73
1.6
2.3
—
—
—
0
0
5
13
3.98
1.73
1.6
2.3
—
—
—
0
0
35
238
1.70
1.70
2.7
2.0
119.06
147.88
u/l
0.47
35
230
10
41
2.58
1.69
1.9
1.2
—
—
—
0
0
29
187
1.76
1.69
2.5
1.6
1.63
0.78
mg/l
0.73
24
153
34
230
1.70
1.68
1.6
1.3
0.68
0.86
u/ml
—
8
63
53
406
1.61
1.60
3.6
2.3
—
—
—
0
0
5
15
3.44
1.54
1.4
1.9
—
—
—
0
0
5
16
3.22
1.45
1.2
1.7
—
—
—
0
0
20
121
1.80
1.43
1.9
1.6
1905.08
1157.84
nmol/l
1.44
13
96
9
48
1.95
1.03
3.0
1.3
—
—
—
0
0
78
696
1.45
0.90
5.1
4.2
14.79
14.61
pmol/l
0.28
70
647
41
329
1.40
0.87
6.3
3.4
—
—
—
0
0
31
237
1.43
0.86
2.1
1.7
1.65
1.32
mmol/l
1.09
25
209
88
806
1.52
0.86
7.2
4.9
40.78
38.84
mmol/mol
0.85
81
760
6
32
1.93
0.83
3.8
3.0
54.62
53.23
%
—
6
32
91
842
1.54
0.81
28.8
10.2
83.31
86.26
ml/min/173m2
0.49
84
683
24
180
1.43
0.73
2.0
1.6
—
—
—
0
0
24
180
1.43
0.73
1.3
1.2
20.81
17.09
iu/ml
—
10
56
5
28
1.82
0.67
2.4
1.1
—
—
—
0
0
5
28
1.82
0.67
2.4
1.1
—
—
—
0
0
9
139
0.62
0.66
3.0
2.3
—
—
—
0
0
0
23
0.00
0.59
0.0
1.7
—
—
—
0
0
8
121
0.63
0.59
2.9
2.2
—
—
—
0
0
6
36
1.71
0.58
1.5
1.5
—
—
—
0
0
6
39
1.57
0.54
1.3
2.5
0.98
1.36
%
—
6
39
27
219
1.31
0.52
1.7
1.7
—
—
—
0
0
7
108
0.62
0.52
2.7
2.6
0.50
0.69
ug/l
—
7
64
7
48
1.49
0.48
7.3
1.5
2.45
2.95
mg/l
—
7
36
35
300
1.25
0.44
4.7
3.5
17.22
31.73
ng/l
0.95
23
175
5
35
1.45
0.40
3.8
2.9
24.22
25.05
mmol/l
—
5
35
5
35
1.45
0.40
1.6
1.7
—
—
—
0
0
9
121
0.72
0.38
1.7
1.7
—
—
—
0
0
13
99
1.36
0.37
18.8
7.3
—
—
—
0
0
21
174
1.26
0.35
1.3
1.2
14.36
8.19
u/ml
—
5
69
7
55
1.29
0.30
1.3
1.3
35.13
24.65
iu/l
—
7
50
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
70
669
1.13
0.20
4.7
3.5
—
—
—
0
0
85
824
1.15
0.19
6.1
4.8
1.82
1.79
mu/l
0.09
77
774
8
67
1.21
0.17
3.9
2.2
—
—
—
0
0
88
861
1.12
0.12
4.4
3.6
1.31
1.31
mmol/l
0.01
79
806
92
904
1.13
0.10
5.3
4.5
2.73
2.85
mmol/l
0.78
87
848
6
56
1.08
0.09
4.5
2.0
—
—
—
0
0
90
886
1.10
0.08
4.9
4.1
1.39
1.49
mmol/l
1.25
85
830
90
893
1.05
0.01
5.1
4.1
4.69
4.77
mmol/l
0.41
84
841
14
146
0.95
0.00
4.6
4.1
16.06
19.51
%
—
9
65
86
856
1.02
0.00
4.9
4.0
6.26
5.82
mmol/l
1.20
81
801
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
126.17
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
68.40
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_LIVDISINOTH and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have K11_LIVDISINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: K11_LIVDISINOTH – Liver disorders in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data