Phlebitis and thrombophlebitis of other deep vessels of lower extremities, drug-induced

PHLEBI_THROMBOP_OTHER_DEEP_VESSE_LOWER_EXTREMITI

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs ANY
  • Hospital discharge: ICD-10 I80.29#

1 out of 7 registries used, show all original rules.

115

4. Check minimum number of events

None

115

5. Include endpoints

None

115

6. Filter based on genotype QC (FinnGen only)

115

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 115 63 52
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 51.10 48.07 54.77

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
108
Matched controls
1079
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
+∞
136.9
108
15
B01AA03
ATC
warfarin; systemic
20.7
42.3
81
136
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
15.9
16.5
27
22
B01AB05
ATC
enoxaparin; parenteral
4.8
13.3
60
221
B01AB04
ATC
dalteparin; parenteral
7.2
8.7
21
35

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
67
4.96
10.67
5.1
3.9
—
—
—
0
0
10
19
5.67
5.14
8.9
3.3
—
—
—
0
0
10
23
4.67
4.18
8.9
3.6
8.4
8.8
kpa
—
10
23
10
23
4.67
4.18
8.9
3.6
4.9
5.0
kpa
—
10
23
19
72
2.96
3.97
7.2
4.5
1.2
1.2
mmol/l
0.25
14
65
67
452
2.16
3.91
4.4
3.6
0.0
0.0
estimate
0.00
23
82
66
446
2.13
3.80
4.4
3.6
0.0
0.0
estimate
0.00
27
85
66
448
2.11
3.73
5.3
4.7
0.0
0.0
estimate
0.00
27
85
44
256
2.16
3.72
5.1
4.0
0.0
0.0
estimate
0.00
23
81
57
382
1.98
3.19
36.4
8.8
1.5
1.2
inr
1.25
33
112
35
199
2.09
3.06
5.8
5.2
—
—
—
0
0
0
74
0.00
2.90
0.0
4.1
—
—
—
0
0
7
16
4.58
2.51
3.0
2.2
63.4
63.3
%
—
7
16
7
16
4.58
2.51
2.3
2.1
6.4
5.5
e9/l
—
7
16
6
12
5.21
2.43
4.5
2.7
88.9
91.3
%
—
6
12
40
257
1.85
2.41
4.0
2.8
0.3
0.4
e6/l
0.06
35
186
7
17
4.31
2.40
6.7
2.6
—
—
—
0
0
39
249
1.86
2.39
4.4
3.3
—
—
—
0
0
16
76
2.28
2.14
4.8
3.7
0.4
0.7
%
—
5
24
12
51
2.51
2.02
5.9
3.0
7.4
7.4
ph
—
7
6
12
52
2.46
1.95
5.9
3.0
5.5
5.2
kpa
0.51
12
46
48
344
1.68
1.92
3.7
3.3
—
—
—
0
0
38
256
1.72
1.90
4.1
2.7
—
—
—
0
0
46
327
1.68
1.89
4.4
3.3
98.1
70.0
e6/l
0.14
38
234
18
97
2.01
1.78
1.9
1.5
—
—
—
0
0
54
407
1.62
1.73
7.6
4.3
34.3
35.4
g/l
0.51
47
386
42
300
1.63
1.66
3.2
3.1
—
—
—
0
0
40
285
1.62
1.59
4.1
3.0
28.9
259.8
e6/l
0.50
35
216
30
199
1.69
1.56
2.1
1.7
624.9
495.3
pmol/l
0.54
20
168
5
15
3.43
1.54
9.2
5.5
—
—
—
0
0
12
59
2.15
1.49
10.8
6.4
25.1
25.0
mmol/l
0.01
12
59
21
131
1.74
1.35
1.5
1.2
1.1
13.7
u/ml
1.79
12
51
72
607
1.50
1.26
5.8
4.3
—
—
—
0
0
51
402
1.48
1.24
20.1
10.0
0.0
0.0
e9/l
0.62
43
325
40
300
1.51
1.24
11.4
3.7
7.4
7.4
ph
0.59
14
53
31
221
1.55
1.20
3.7
3.4
—
—
—
0
0
49
388
1.46
1.15
5.1
4.0
37.8
40.0
ng/l
0.04
37
281
9
45
2.08
1.08
1.1
1.2
—
—
—
0
0
17
109
1.66
1.00
1.2
1.2
—
—
—
0
0
0
30
0.00
0.99
0.0
1.2
—
—
—
0
0
76
665
1.42
0.97
5.1
4.1
—
—
—
0
0
0
32
0.00
0.96
0.0
2.5
—
0.2
—
0
10
36
279
1.42
0.92
2.9
3.0
—
—
—
0
0
38
300
1.40
0.87
9.5
5.2
—
—
—
0
0
12
75
1.67
0.78
8.5
2.5
9.5
10.0
g/l
0.25
12
64
21
281
0.69
0.76
2.4
2.2
—
—
—
0
0
7
40
1.80
0.73
3.3
4.6
—
—
—
0
0
5
92
0.52
0.70
13.6
3.1
—
—
—
0
0
5
28
1.82
0.67
1.0
1.1
—
—
—
0
0
24
184
1.38
0.65
2.0
1.8
1362.7
1271.1
nmol/l
0.28
15
141
10
63
1.64
0.64
4.1
2.2
—
—
—
0
0
48
413
1.28
0.59
8.2
5.8
3.0
2.9
%
0.08
43
387
5
87
0.56
0.59
12.2
3.2
2.6
1.8
mmol/l
—
5
66
32
261
1.31
0.59
6.5
4.4
—
—
—
0
0
79
851
0.77
0.58
4.3
4.2
1.5
1.3
mmol/l
1.60
73
771
12
82
1.52
0.57
1.8
1.6
—
—
—
0
0
9
59
1.57
0.56
2.0
1.5
1.0
1.1
g/l
—
9
49
6
38
1.61
0.55
3.3
1.2
—
—
—
0
0
9
63
1.46
0.54
3.4
2.9
—
—
—
0
0
51
450
1.24
0.49
8.8
5.5
0.0
0.0
e9/l
0.38
45
391
5
32
1.59
0.43
2.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
8
61
1.33
0.40
2.1
2.1
11.3
13.3
nmol/l
—
8
56
50
448
1.21
0.40
8.9
5.5
0.6
0.6
e9/l
0.82
44
388
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
84
885
0.81
0.39
4.8
4.7
4.5
4.6
mmol/l
0.34
79
821
30
257
1.23
0.37
2.2
1.7
1.4
1.3
mmol/l
0.20
23
224
51
461
1.19
0.37
9.9
5.8
0.2
0.2
e9/l
0.10
45
408
88
919
0.82
0.34
23.5
14.5
—
—
—
0
0
7
100
0.68
0.32
4.9
5.0
2.8
51.0
ug/l
—
7
86
15
120
1.29
0.32
1.3
1.4
—
—
—
0
0
50
456
1.17
0.31
8.9
5.6
1.8
2.1
e9/l
0.61
44
405
10
75
1.37
0.31
17.7
5.2
11.0
9.3
mmol/l
—
10
69
95
981
0.82
0.28
35.4
22.4
135.5
134.6
g/l
0.27
95
965
87
904
0.85
0.27
5.4
5.3
2.6
2.7
mmol/l
0.34
82
830
10
77
1.33
0.27
4.7
2.2
68.1
65.8
g/l
—
10
66
11
87
1.29
0.25
1.7
1.3
—
—
—
0
0
11
87
1.29
0.25
5.6
1.9
333.5
394.5
nmol/l
0.66
11
82
56
523
1.14
0.24
14.5
10.2
4.2
3.9
e9/l
0.62
49
457
14
116
1.24
0.23
12.1
5.0
1.0
1.0
mmol/l
0.44
14
107
75
783
0.88
0.22
26.4
16.7
40.8
39.6
%
0.95
48
547
17
145
1.20
0.22
1.5
1.3
13.9
37.9
iu/ml
—
7
48
85
880
0.87
0.22
4.6
4.7
1.4
1.5
mmol/l
0.82
80
806
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
12.0
—
0
10
0
10
0.00
0.21
0.0
3.8
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
55.7
—
0
6
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
6
48
1.26
0.20
1.2
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
33
301
1.14
0.20
5.4
3.7
18.4
6.7
mg/mmol
0.38
20
182
21
185
1.17
0.19
4.6
3.4
204.8
114.1
ng/l
0.19
16
147
36
390
0.89
0.19
1.8
2.0
105.2
95.6
pmol/l
0.82
18
192
8
69
1.17
0.17
8.9
4.5
—
—
—
0
0
8
70
1.15
0.16
1.5
1.5
—
—
—
0
0
85
875
0.89
0.16
5.1
4.9
5.9
6.0
mmol/l
0.34
79
805
35
376
0.90
0.16
2.7
2.0
—
—
—
0
0
15
131
1.17
0.15
1.5
1.3
—
—
—
0
0
10
84
1.21
0.14
3.1
2.5
0.2
0.2
g/l
—
10
76
9
109
0.81
0.13
2.2
1.8
—
—
—
0
0
21
192
1.11
0.12
1.5
1.2
0.8
0.8
u/ml
0.07
11
55
91
892
1.10
0.10
27.5
15.2
19.0
21.5
mg/l
0.48
82
724
20
217
0.91
0.10
1.7
1.4
—
—
—
0
0
5
47
1.07
0.09
3.2
3.5
—
—
—
0
0
11
124
0.88
0.09
1.6
1.3
—
—
—
0
0
6
53
1.14
0.09
13.5
7.6
—
—
—
0
0
7
68
1.03
0.08
13.4
8.5
26.7
24.7
mmol/l
—
7
62
94
954
0.92
0.08
27.5
17.7
80.5
78.7
umol/l
0.21
94
954
7
82
0.84
0.07
1.3
1.3
—
—
—
0
0
13
118
1.11
0.07
11.4
7.4
12.1
12.1
kpa
0.03
13
113
13
118
1.11
0.07
11.4
7.4
5.6
5.1
kpa
0.46
13
113
9
84
1.08
0.07
4.9
3.2
—
—
—
0
0
9
85
1.06
0.07
1.7
1.6
—
—
—
0
0
15
138
1.10
0.07
3.0
1.7
—
—
—
0
0
87
857
1.06
0.06
6.1
6.2
41.2
40.7
mmol/mol
0.15
82
801
23
242
0.94
0.05
17.1
7.4
—
—
—
0
0
10
91
1.11
0.04
1.8
1.5
—
—
—
0
0
29
281
1.04
0.03
3.9
3.0
1920.9
49.2
mg/l
0.50
20
182
28
287
0.97
0.01
3.4
4.1
—
—
—
0
0
11
107
1.03
0.00
11.6
8.0
96.4
95.6
%
0.44
11
102
42
425
0.98
0.00
14.5
5.6
1.2
1.2
mmol/l
0.06
35
386
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
16.8
—
1367.4
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
13.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
11.0
—
938.0
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
14.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
6.1
—
0
5
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
3.8
—
3.1
—
0
8
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
1.7
—
0
6
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.6
—
—
—
0
0
0
6
0.00
0.00
0.0
12.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
8.3
—
0.6
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

Index endpoint: PHLEBI_THROMBOP_OTHER_DEEP_VESSE_LOWER_EXTREMITI – Phlebitis and thrombophlebitis of other deep vessels of lower extremities, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).