Phlebitis and thrombophlebitis of other deep vessels of lower extremities, drug-induced

PHLEBI_THROMBOP_OTHER_DEEP_VESSE_LOWER_EXTREMITI

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs ANY
  • Hospital discharge: ICD-10 I80.29#

1 out of 7 registries used, show all original rules.

115

4. Check minimum number of events

None

115

5. Include endpoints

None

115

6. Filter based on genotype QC (FinnGen only)

112

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 112 63 49
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 50.92 48.07 54.58

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
115
Matched controls
1150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
+∞
142.4
115
20
B01AA03
ATC
warfarin; systemic
18.2
53.0
87
168
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
20.6
21.3
32
21
B01AB05
ATC
enoxaparin; parenteral
4.5
14.5
66
265
B01AB04
ATC
dalteparin; parenteral
14.8
14.4
24
20
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
14.1
9.7
16
13

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
67
4.96
10.67
5.1
3.9
—
—
—
0
0
19
72
2.96
3.97
7.2
4.5
1.23
1.22
mmol/l
0.25
14
65
10
19
5.65
3.92
8.9
3.3
—
—
—
0
0
67
452
2.16
3.91
4.4
3.6
0.00
0.00
estimate
-0.00
23
82
66
448
2.11
3.73
4.4
3.6
0.00
0.01
estimate
0.49
27
91
66
448
2.11
3.73
5.3
4.7
0.00
0.00
estimate
-0.00
27
85
44
256
2.16
3.72
5.1
4.0
0.00
0.00
estimate
-0.00
23
81
10
23
4.66
3.40
8.9
3.6
8.36
8.82
kpa
—
10
23
10
23
4.66
3.40
8.9
3.6
4.86
4.97
kpa
—
10
23
65
457
1.97
3.15
46.9
15.2
1.54
1.25
inr
1.35
34
129
0
74
0.00
2.90
0.0
4.1
—
—
—
0
0
7
16
4.58
2.51
2.3
2.1
6.39
5.53
e9/l
—
7
16
7
16
4.58
2.51
3.0
2.3
63.43
63.31
%
—
7
16
6
12
5.21
2.43
4.5
2.7
88.87
91.34
%
—
6
12
7
17
4.31
2.40
6.7
2.6
—
—
—
0
0
39
249
1.86
2.39
4.3
3.3
—
—
—
0
0
16
76
2.28
2.14
4.8
3.7
0.40
0.85
%
—
5
33
15
71
2.28
2.03
5.0
3.5
0.00
0.71
%
—
5
29
12
51
2.51
2.02
5.9
3.0
7.39
7.42
ph
—
7
6
38
256
1.72
1.90
4.1
2.7
—
—
—
0
0
46
327
1.68
1.89
4.4
3.3
98.14
70.03
e6/l
0.14
38
234
18
97
2.01
1.78
1.9
1.5
—
—
—
0
0
54
407
1.62
1.73
7.6
4.3
34.27
35.36
g/l
0.51
47
387
42
300
1.63
1.66
3.2
3.1
—
—
—
0
0
40
285
1.62
1.59
4.1
3.0
28.90
259.77
e6/l
0.50
35
216
30
199
1.69
1.56
2.1
1.7
624.85
495.31
pmol/l
0.54
20
168
5
15
3.43
1.54
9.2
5.5
—
—
—
0
0
12
59
2.15
1.49
10.8
6.4
25.05
25.00
mmol/l
0.01
12
59
21
131
1.74
1.35
1.5
1.2
1.13
13.71
u/ml
1.79
12
51
72
607
1.50
1.26
5.5
4.2
—
—
—
0
0
51
402
1.48
1.24
20.1
10.0
0.00
0.00
e9/l
0.62
43
325
40
300
1.51
1.24
11.4
3.7
7.41
7.39
ph
0.59
14
54
53
423
1.47
1.20
10.7
6.1
—
—
—
0
0
31
221
1.55
1.20
3.7
3.4
—
—
—
0
0
49
388
1.46
1.15
5.1
4.0
37.80
40.01
ng/l
0.04
37
281
9
45
2.08
1.08
1.1
1.2
—
—
—
0
0
17
109
1.66
1.00
1.2
1.2
—
—
—
0
0
0
30
0.00
0.99
0.0
1.2
—
—
—
0
0
76
665
1.42
0.97
5.1
4.1
—
—
—
0
0
0
32
0.00
0.96
0.0
2.5
—
0.19
—
0
10
36
282
1.40
0.86
2.9
3.0
—
—
—
0
0
12
75
1.67
0.78
8.5
2.5
9.47
9.97
g/l
0.25
12
64
21
281
0.69
0.76
2.4
2.2
—
—
—
0
0
7
40
1.80
0.73
3.3
4.6
—
—
—
0
0
7
118
0.57
0.72
9.9
7.1
103.71
103.49
mmol/l
—
7
118
5
28
1.82
0.67
1.0
1.1
—
—
—
0
0
24
184
1.38
0.65
2.0
1.8
1362.73
1271.10
nmol/l
0.28
15
141
10
63
1.64
0.64
4.1
2.2
—
—
—
0
0
12
81
1.54
0.60
1.8
1.6
—
—
—
0
0
5
87
0.56
0.59
12.2
3.2
2.58
1.85
mmol/l
—
5
68
32
261
1.31
0.59
6.5
4.4
—
—
—
0
0
79
851
0.77
0.58
4.3
4.2
1.52
1.29
mmol/l
1.60
73
771
9
59
1.57
0.56
2.0
1.5
1.01
1.11
g/l
—
9
49
6
38
1.61
0.55
3.3
1.2
—
—
—
0
0
9
63
1.46
0.54
3.4
2.9
—
—
—
0
0
51
449
1.24
0.50
8.8
5.5
0.63
0.60
e9/l
0.56
45
391
51
450
1.24
0.49
8.8
5.5
0.05
0.04
e9/l
0.38
45
392
52
461
1.23
0.48
9.8
5.8
0.20
0.20
e9/l
0.04
46
408
5
32
1.59
0.43
2.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
51
457
1.21
0.41
8.8
5.6
1.81
2.07
e9/l
0.65
45
409
8
61
1.33
0.40
2.1
2.1
11.28
13.30
nmol/l
—
8
56
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
84
885
0.81
0.39
4.8
4.7
4.51
4.60
mmol/l
0.34
79
821
30
257
1.23
0.37
2.2
1.7
1.39
1.32
mmol/l
0.20
23
224
57
523
1.18
0.34
14.3
10.2
4.20
3.91
e9/l
0.51
50
457
88
918
0.82
0.32
23.4
14.5
—
—
—
0
0
7
100
0.68
0.32
4.9
5.0
2.84
50.96
ug/l
—
7
86
15
120
1.29
0.32
1.3
1.4
—
—
—
0
0
7
53
1.34
0.31
9.0
8.8
23.81
24.76
mmol/l
—
7
53
10
75
1.37
0.31
17.7
5.2
11.05
9.34
mmol/l
—
10
69
95
981
0.82
0.28
35.4
22.4
135.55
134.57
g/l
0.27
95
965
95
981
0.82
0.28
34.7
22.4
41.12
40.10
%
1.29
89
917
87
904
0.85
0.27
5.4
5.3
2.60
2.68
mmol/l
0.33
82
830
10
77
1.33
0.27
4.6
2.2
67.91
65.79
g/l
—
10
66
11
87
1.29
0.25
5.6
1.9
333.45
394.55
nmol/l
0.66
11
82
11
87
1.29
0.25
1.7
1.3
—
—
—
0
0
14
116
1.24
0.23
12.1
5.0
0.97
1.04
mmol/l
0.44
14
107
17
145
1.20
0.22
1.5
1.3
13.86
37.23
iu/ml
—
7
49
85
880
0.87
0.22
4.6
4.7
1.41
1.49
mmol/l
0.82
80
806
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
—
—
0
0
0
10
0.00
0.21
0.0
3.8
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
11.96
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
48
1.26
0.20
1.2
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
33
301
1.14
0.20
4.8
3.6
18.40
6.72
mg/mmol
0.38
20
182
21
185
1.17
0.19
4.6
3.4
204.84
114.05
ng/l
0.19
16
147
36
390
0.89
0.19
1.8
2.0
105.16
95.65
pmol/l
0.82
18
192
8
69
1.17
0.17
8.9
4.5
—
—
—
0
0
8
70
1.15
0.16
1.5
1.5
—
—
—
0
0
85
875
0.89
0.16
5.1
4.9
5.92
6.03
mmol/l
0.34
79
805
35
376
0.90
0.16
2.7
2.0
—
—
—
0
0
15
131
1.17
0.15
1.5
1.3
—
—
—
0
0
10
84
1.21
0.14
3.1
2.5
0.20
0.21
g/l
—
10
76
9
109
0.81
0.13
2.2
1.8
—
—
—
0
0
21
192
1.11
0.12
1.5
1.2
0.81
0.78
u/ml
0.07
11
55
91
892
1.10
0.10
27.5
15.2
18.97
21.51
mg/l
0.48
82
724
44
460
0.93
0.10
13.3
6.7
1.21
1.21
mmol/l
0.01
27
395
20
217
0.91
0.10
1.7
1.4
—
—
—
0
0
5
47
1.07
0.09
3.2
3.5
—
—
—
0
0
11
124
0.88
0.09
1.6
1.3
—
—
—
0
0
6
53
1.14
0.09
13.5
7.6
—
—
—
0
0
7
68
1.03
0.08
13.4
8.5
26.79
24.75
mmol/l
—
7
63
94
954
0.92
0.08
27.5
17.7
80.47
78.66
umol/l
0.21
94
954
7
82
0.84
0.07
1.3
1.3
—
—
—
0
0
13
118
1.11
0.07
11.4
7.4
12.05
12.14
kpa
0.03
13
113
13
118
1.11
0.07
11.4
7.4
5.58
5.14
kpa
0.46
13
113
9
84
1.08
0.07
4.9
3.2
—
—
—
0
0
9
85
1.06
0.07
1.7
1.6
—
—
—
0
0
15
138
1.10
0.07
3.0
1.7
—
—
—
0
0
87
857
1.06
0.06
6.1
6.2
41.18
40.71
mmol/mol
0.15
82
801
23
242
0.94
0.05
17.1
7.4
—
—
—
0
0
10
91
1.11
0.04
1.8
1.5
—
—
—
0
0
29
281
1.04
0.03
3.9
3.0
1920.92
49.25
mg/l
0.50
20
182
28
287
0.97
0.01
3.4
4.1
—
—
—
0
0
11
107
1.03
0.00
11.6
8.0
96.35
95.60
%
0.44
11
102
42
425
0.98
0.00
14.5
5.6
1.21
1.21
mmol/l
0.08
35
388
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
14.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
11.0
—
938.00
—
0
5
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
13.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
16.8
—
1367.40
—
0
5
0
8
0.00
0.00
0.0
3.8
—
3.13
—
0
8
0
5
0.00
0.00
0.0
3.0
—
6.10
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
1.54
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.65
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
12.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
0.83
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
8.3
—
0.59
—
0
6

Mortality – FinRegistry

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

Index endpoint: PHLEBI_THROMBOP_OTHER_DEEP_VESSE_LOWER_EXTREMITI – Phlebitis and thrombophlebitis of other deep vessels of lower extremities, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).