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Cleft lip and palate

Q17_CLEFT_LIP_AND_PALATE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • not Q17_CLEFT_PALATE_EXCLUDE
519447

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q37
  • Hospital discharge: ICD-9 7492[ABCDE]
  • Hospital discharge: ICD-8 74920|74924
  • Cause of death: ICD-10 Q37
  • Cause of death: ICD-9 7492[ABCDE]
  • Cause of death: ICD-8 74920|74924

2 out of 7 registries used, show all original rules.

220

4. Check minimum number of events

None

220

5. Include endpoints

None

220

6. Filter based on genotype QC (FinnGen only)

220

Control definitions (FinnGen only)

Control conditions
not Q17_CLEFT_PALATE_EXCLUDE

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 220 119 101
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 10.73 14.85 5.87

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
197
Matched controls
1980
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
+∞
153.9
127
*
74920
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis unilateralis
+∞
100.8
88
*
7492A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS UNILATERALIS COMPLETA]
+∞
67.6
61
*
Q37.0
ICD-10 Finland
Cleft hard palate with bilateral cleft lip
+∞
59.4
54
*
4361
FHL
Lip plastic or reconstruction due to cleft lip
+∞
50.1
46
*
SBB10
NOMESCO Finland
Teeth copy
13.4
41.2
78
91
74924
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis bilateralis
+∞
41.1
38
*
EAB30
NOMESCO Finland
Correction of cleft lip
+∞
41.1
38
*
Q35.1
ICD-10 Finland
Cleft hard palate
476.6
40.6
39
*
4367
FHL
Bone transfer to the upper jaw
+∞
36.6
34
*
ECB17
NOMESCO Finland
Operation for cleft gingiva
+∞
36.6
34
*
7492C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS BILATERALIS COMPLETA]
+∞
35.5
33
*
4368
FHL
Closing the fistula of the mouth
+∞
33.3
31
*
SAA04
NOMESCO Finland
Special inverstigation of mouth
15.8
32.5
55
47
SJX10
NOMESCO Finland
Short check-up visit for orthodontisk therapy
22.4
32.1
47
27
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
17.2
29.7
48
36
EEC05
NOMESCO Finland
Le Fort I osteotomy
338.7
29.6
29
*
4365
FHL
Correction of nasal deformity
+∞
28.8
27
*
4364
FHL
Pharyngeal tongue plastic
+∞
26.7
25
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
10.2
26.2
55
72
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
31.2
25.9
34
13
EBB10
NOMESCO Finland
Insertion of dental implant
28.9
25.4
34
14
4362
FHL
Nozzle reconstruction
271.2
24.2
24
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
10.2
24.1
50
63
K00.00
ICD-10 Finland
Hypodontia
38.9
24.1
30
9
DLW00
NOMESCO Finland
Correction of cleft nose
+∞
23.4
22
*
74929
ICD-8 Finland
Cleft palate and cleft lip, Unspecified
+∞
22.3
21
*
ZSZ10
NOMESCO Finland
Secondary repair operation
245.8
22.1
22
*
SJD00
NOMESCO Finland
Removal or reattacment of arrow in fixed orthodontisk device
17.6
21.6
34
23
EB1MA
NOMESCO Finland
Cephalometry with X-ray
13.9
21.3
37
32
Q35.9
ICD-10 Finland
Cleft palate, unspecified
+∞
21.2
20
*
DLD20
NOMESCO Finland
Rhinoplasty
221.0
19.9
20
*
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
13.4
19.4
34
30
EHC10
NOMESCO Finland
Plastic repair of oronasal or oroantral fistula of palate
+∞
19.1
18
*
SJD20
NOMESCO Finland
Attachment of modifiable arrow of fixed orthodontisk device
18.6
19.0
29
18
Q37.99
ICD-10 Finland
Cleft palate with cleft lip NOS
+∞
18.0
17
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.8
17.1
101
424
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
69.5
17.1
19
*
4366
FHL
Upper jaw scar repair surgery
+∞
16.9
16
*
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
+∞
16.9
16
*
4122
FHL
Tympanostomy (tympanic tube)
13.4
16.7
29
25
SJC50
NOMESCO Finland
Removal of orthodontisk device with at least 7 brackets
16.4
16.4
26
18
74912
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis unilateralis
+∞
14.8
14
*
SJA04
NOMESCO Finland
Very demanding plan for orthodontic care
+∞
14.8
14
*
EBB15
NOMESCO Finland
Insertion of dental implant abutment
24.5
14.5
20
9
SJD10
NOMESCO Finland
Attachment of arrow to fixed orthodontisk device
13.5
14.0
24
20
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
13.5
14.0
24
20
SJD40
NOMESCO Finland
Fixation of ready made palatinal or lingual arrow
10.6
14.0
27
29
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
36.9
13.7
17
5
Q36.9
ICD-10 Finland
Cleft lip, unilateral
+∞
13.7
13
*
4347
FHL
Osteotomy of the upper jaw
+∞
13.7
13
*
SAA03
NOMESCO Finland
Extended examination of mouth
3.2
13.7
117
618
K07.14
ICD-10 Finland
Retrognaty, maxillary
28.0
13.6
18
7
SJD30
NOMESCO Finland
Demanding attachment of arrow to fixed orthodontisk device
15.3
13.6
22
16
ZZG00
NOMESCO Finland
Graft of cartilage
74.7
12.8
14
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
28.8
12.2
16
6
4204
FHL
Molding of the cartilaginous part of the nose
127.0
11.5
12
*
7490A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS COMPLETA]
127.0
11.5
12
*
SPA20
NOMESCO Finland
Selection and insertion of implantdistans
127.0
11.5
12
*
SXC05
NOMESCO Finland
Other oral or dental procedure
5.9
11.4
32
62
SPC20
NOMESCO Finland
Attachment of crone of tooth to implant
21.6
11.3
16
8
SJB60
NOMESCO Finland
External device grinding and adaptation
14.0
10.9
18
14
9808
FHL
Bone graft
63.4
10.7
12
*
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
63.4
10.7
12
*
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
115.8
10.5
11
*
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
8.7
10.4
22
28
J34.2
ICD-10 Finland
Deviated nasal septum
7.0
10.2
25
40
H65.3
ICD-10 Finland
Chronic mucoid otitis media
8.9
10.1
21
26
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
13.1
10.1
17
14
SPF30
NOMESCO Finland
Soling for prothesis
57.8
9.7
11
*
SJC00
NOMESCO Finland
Bracket with fixed attachment
57.8
9.7
11
*
SJC10
NOMESCO Finland
Orthodontic bandage in one tooth
10.9
9.7
18
18
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
16.1
9.7
15
10
1450
FHL
Otomicroscopy
31.7
9.5
12
*
4203
FHL
Mobilization and repositioning of the external pyramid
104.7
9.5
10
*
Q37.3
ICD-10 Finland
Cleft soft palate with unilateral cleft lip
+∞
9.4
9
*
Q37.90
ICD-10 Finland
Unspecified cheft palate with cleft lip, unilateral
+∞
9.4
9
*
ZXB10
NOMESCO Finland
Medial
25.4
9.0
12
5
SJD50
NOMESCO Finland
Production and attachment of palatinal or lingual arrow
52.3
8.8
10
*
EDC10
NOMESCO Finland
Sagittal osteotomy of ramus of mandible
52.3
8.8
10
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.5
8.7
99
566
SJB00
NOMESCO Finland
Fitting of loose orthodontic device with user information
8.0
8.7
19
26
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
17.2
8.7
13
8
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
10.1
8.4
16
17
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
7.0
8.4
20
31
EHC40
NOMESCO Finland
Correction of submucous cleft palate
+∞
8.4
8
*
ECB60
NOMESCO Finland
Reconstruction of alveolus
+∞
8.4
8
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
8.4
70
335
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
34.9
8.2
10
*
SPB10
NOMESCO Finland
Production of temporary crone to tooth
23.1
8.1
11
5
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
4.6
8.1
28
69
EBA10
NOMESCO Finland
Surgical removal of tooth
3.0
7.9
48
188
SPF10
NOMESCO Finland
Demanding repatation of teeth prosthesis
15.8
7.8
12
8
ZZH22
NOMESCO Finland
Graft of patients own bone, block
46.8
7.8
9
*
SPA10
NOMESCO Finland
Setting attachments on tooth or implanted bracket or imblant based structures
46.8
7.8
9
*
UDC00
NOMESCO Finland
Ear microscopy
4.5
7.8
27
67
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
12.5
7.7
13
11
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
19.3
7.7
11
6
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
19.3
7.7
11
6
SPF20
NOMESCO Finland
Temporary soling for filling
26.1
7.6
10
*
DLD10
NOMESCO Finland
Reconstruction of cartilage and bone of nose
26.1
7.6
10
*
SJA03
NOMESCO Finland
Demanding plan for orthodontic care
83.0
7.5
8
*
7491F
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOGNATOSCHISIS UNILATERALIS INCOMPLETA]
+∞
7.3
7
*
Q37.8
ICD-10 Finland
Unspecified cleft palate with bilateral cleft lip
+∞
7.3
7
*
Q35.71
ICD-10 Finland
Submucous cleft palate
+∞
7.3
7
*
SJC40
NOMESCO Finland
Removal of orthodontisk device with at most 6 brackets
8.0
7.0
15
20
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
7.1
7.0
16
24
SPB20
NOMESCO Finland
Temporary bridge between two or more teeth
17.4
6.8
10
6
SPC10
NOMESCO Finland
Attachment of standard crone of tooth
12.8
6.7
11
9
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
6.1
6.6
17
30
SJB10
NOMESCO Finland
Fitting of loose orthodontic device with user information, demanding
14.9
6.5
10
7
7490B
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS INCOMPLETA]
72.0
6.5
7
*
DLD00
NOMESCO Finland
Reconstruction of cartilage of nose
72.0
6.5
7
*
SPC30
NOMESCO Finland
Tooth bridge attacment with resins
72.0
6.5
7
*
74910
ICD-8 Finland
Cleft palate and cleft lip, Cheiloschisis unilateralis
+∞
6.3
6
*
74913
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis bilateralis
+∞
6.3
6
*
Q67.48
ICD-10 Finland
Other specified congenital deformity of skull, face or jaw
+∞
6.3
6
*
SPD05
NOMESCO Finland
Demanding fitting of total teeth prosthesis
+∞
6.3
6
*
ENC80
NOMESCO Finland
Plastic operation of soft palate for voice distubance
+∞
6.3
6
*
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
3.1
6.2
35
130
EBA00
NOMESCO Finland
Extraction of tooth
2.2
6.1
77
443
SXC03
NOMESCO Finland
Other oral or dental procedure
7.6
6.0
13
18

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
31
181
1.83
2.30
2.2
1.5
—
—
—
0
0
64
489
1.44
1.59
2.5
2.1
—
—
—
0
0
167
1803
0.68
1.52
10.9
10.8
23.4
21.4
mg/l
0.27
123
1359
5
16
3.17
1.44
8.8
1.7
—
—
—
0
0
7
29
2.46
1.40
1.0
1.1
—
—
—
0
0
27
390
0.65
1.29
4.2
3.1
—
—
—
0
0
24
159
1.57
1.18
12.4
7.1
104.7
104.8
mmol/l
0.05
24
154
14
81
1.78
1.11
9.1
11.9
95.9
94.5
%
1.34
14
81
7
32
2.22
1.09
1.1
1.2
—
—
—
0
0
21
301
0.67
0.98
1.2
1.3
—
—
—
0
0
14
85
1.69
0.96
9.0
11.5
0.7
0.8
%
0.18
14
85
14
85
1.69
0.96
9.1
11.5
1.4
1.5
%
0.15
14
85
21
300
0.67
0.96
1.3
1.3
43.4
24.9
iu/ml
—
5
98
20
287
0.67
0.94
1.4
1.3
1.3
6.6
u/ml
—
10
111
7
126
0.54
0.91
1.4
1.7
—
—
—
0
0
7
130
0.52
0.91
2.0
2.4
—
16.0
—
0
6
41
515
0.75
0.90
9.3
6.3
1.3
1.1
inr
—
9
142
62
515
1.28
0.87
2.0
1.7
89.3
98.6
pmol/l
1.00
36
264
18
121
1.53
0.85
16.2
10.3
—
—
—
0
0
10
58
1.76
0.81
4.3
21.6
—
—
—
0
0
42
516
0.77
0.78
1.5
1.5
—
—
—
0
0
20
141
1.46
0.77
7.0
12.6
13.2
12.8
kpa
0.09
20
134
20
141
1.46
0.77
7.0
12.7
5.2
5.2
kpa
0.01
20
133
19
264
0.69
0.77
1.2
1.8
—
—
—
0
0
11
67
1.68
0.76
11.8
4.3
120.6
132.9
g/l
0.64
11
67
6
109
0.54
0.74
5.3
3.4
4.3
4.8
pmol/l
—
6
97
37
459
0.77
0.74
2.7
2.5
—
—
—
0
0
14
92
1.56
0.74
9.4
8.2
26.1
25.3
mmol/l
0.37
14
92
18
126
1.47
0.73
7.3
13.7
96.1
96.6
%
0.10
18
120
20
271
0.71
0.71
3.0
2.3
101.9
87.8
ug/g
0.16
15
214
62
719
0.81
0.71
2.5
2.4
—
—
—
0
0
9
58
1.57
0.70
2.8
3.9
25.7
24.4
mmol/l
—
9
58
19
137
1.42
0.67
10.8
5.0
—
—
—
0
0
116
1256
0.84
0.63
4.2
3.7
9.0
8.9
mm/h
0.01
111
1166
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
0
21
0.00
0.60
0.0
3.5
—
2.4
—
0
21
0
22
0.00
0.59
0.0
1.4
—
—
—
0
0
7
115
0.60
0.59
1.0
1.3
—
23.1
—
0
7
0
23
0.00
0.58
0.0
2.8
—
—
—
0
0
41
341
1.25
0.58
1.6
2.0
2.9
2.9
mg/l
0.01
36
285
13
90
1.47
0.56
1.0
1.3
—
—
—
0
0
8
124
0.63
0.56
4.5
5.1
—
—
—
0
0
14
192
0.71
0.55
1.5
1.8
—
—
—
0
0
19
143
1.36
0.54
7.3
12.5
2.0
1.0
mmol/l
0.53
19
110
62
545
1.19
0.52
3.3
3.2
32.7
70.3
e6/l
0.52
41
365
43
365
1.22
0.51
4.3
3.2
—
—
—
0
0
185
1907
0.80
0.51
9.7
9.6
—
—
—
0
0
51
441
1.20
0.51
3.0
3.0
8.2
8.8
mmol/l
0.32
45
383
7
46
1.54
0.49
7.0
2.1
—
—
—
0
0
7
46
1.54
0.49
1.9
1.6
0.4
0.9
nmol/l
—
7
38
118
1259
0.86
0.48
7.8
7.0
78.7
79.4
u/l
0.07
113
1189
7
51
1.38
0.44
1.7
1.2
—
—
—
0
0
6
93
0.63
0.43
4.7
4.6
—
—
—
0
0
82
893
0.87
0.43
6.0
5.8
0.5
0.6
e9/l
0.74
72
761
8
56
1.44
0.43
1.1
1.3
—
—
—
0
0
8
57
1.42
0.42
2.0
1.3
—
60.0
—
0
7
8
57
1.42
0.42
15.1
3.6
1.2
1.4
%
—
8
57
5
32
1.57
0.42
1.2
1.7
—
—
—
0
0
46
523
0.85
0.42
2.8
3.1
24.4
23.3
ng/l
0.03
27
305
25
205
1.25
0.41
2.1
2.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
17.2
—
0
8
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
3.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
5
34
1.48
0.40
1.6
19.7
1.1
1.2
mmol/l
—
5
28
22
178
1.26
0.40
1.1
1.5
—
—
—
0
0
58
645
0.86
0.40
1.9
1.9
—
—
—
0
0
15
115
1.33
0.40
7.7
12.4
120.4
127.2
g/l
0.58
15
109
36
309
1.20
0.39
2.2
2.2
10.5
4.6
e6/l
0.83
31
278
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
2.4
—
—
—
0
0
42
478
0.85
0.39
1.8
1.9
—
—
—
0
0
55
491
1.16
0.39
2.1
3.1
2.4
2.4
mmol/l
0.52
45
441
171
1764
0.86
0.38
13.4
11.3
40.3
41.1
%
0.69
138
1461
108
1146
0.89
0.37
4.8
3.7
—
—
—
0
0
24
199
1.23
0.37
1.5
1.5
723.6
1231.2
nmol/l
2.54
18
152
23
190
1.23
0.36
1.4
1.4
—
—
—
0
0
83
894
0.88
0.36
6.0
5.8
0.0
0.0
e9/l
0.10
73
763
6
44
1.37
0.34
1.0
1.5
—
—
—
0
0
96
1022
0.89
0.34
7.9
9.3
3.8
3.9
e9/l
0.25
79
884
86
921
0.89
0.33
5.8
6.3
0.2
0.2
e9/l
0.48
75
804
6
46
1.31
0.33
1.2
1.6
—
—
—
0
0
202
2051
0.79
0.33
16.2
15.9
261.7
254.7
e9/l
0.81
196
1994
86
917
0.90
0.30
5.9
5.8
1.8
1.9
e9/l
0.59
76
801
138
1323
1.12
0.30
4.2
3.7
14.3
14.6
pmol/l
0.54
131
1226
40
356
1.15
0.30
3.0
3.2
435.9
60.9
mg/l
0.47
31
233
76
814
0.90
0.29
5.7
5.8
0.8
0.7
%
0.74
71
761
28
243
1.17
0.28
2.1
2.3
2.4
2.4
mmol/l
0.02
23
213
9
120
0.74
0.28
4.2
3.3
—
—
—
0
0
29
253
1.17
0.28
2.8
3.1
11.2
314.3
ng/l
1.82
19
169
171
1664
1.13
0.26
15.3
13.4
333.3
334.2
g/l
0.61
171
1654
10
127
0.78
0.26
1.5
1.4
—
—
—
0
0
203
2054
0.82
0.23
16.1
15.9
6.5
6.6
e9/l
0.08
197
1992
39
428
0.89
0.23
4.7
7.0
—
—
—
0
0
5
40
1.26
0.22
1.8
1.2
—
—
—
0
0
5
40
1.26
0.22
1.0
1.2
—
—
—
0
0
5
40
1.26
0.22
1.0
1.2
—
—
—
0
0
33
365
0.89
0.22
4.8
3.2
1.0
1.0
kg/l
—
5
41
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
1601.2
—
0
10
0
10
0.00
0.21
0.0
1.6
—
0.2
—
0
10
0
12
0.00
0.21
0.0
1.5
—
135.2
—
0
12
0
12
0.00
0.21
0.0
1.4
—
7.8
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
6.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
3.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
29
260
1.13
0.20
1.6
1.6
—
—
—
0
0
20
174
1.16
0.20
1.2
1.4
—
—
—
0
0
54
578
0.91
0.20
5.2
5.7
—
—
—
0
0
203
2052
0.84
0.20
16.1
15.9
4.7
4.6
e12/l
0.69
197
1990
80
841
0.92
0.20
6.2
5.9
8.1
8.5
%
0.46
73
796
6
52
1.16
0.19
2.3
4.2
—
—
—
0
0
39
358
1.11
0.19
1.6
2.0
0.9
1.3
mg/l
0.47
33
276
112
1080
1.08
0.18
2.7
3.0
—
—
—
0
0
41
379
1.10
0.18
3.6
3.7
7.3
10.8
mg/mmol
0.36
33
242
11
130
0.84
0.16
1.2
1.4
—
—
—
0
0
40
429
0.92
0.16
3.6
3.2
0.0
0.0
estimate
0.50
14
152
80
834
0.93
0.15
5.8
5.7
2.8
2.9
%
0.08
75
783
10
83
1.21
0.15
18.2
4.9
23.9
23.9
mmol/l
—
10
78
9
79
1.14
0.15
2.8
13.0
26.0
24.2
mmol/l
—
9
74
170
1727
0.93
0.14
3.5
3.8
1.4
1.5
mmol/l
0.88
162
1623
48
453
1.08
0.13
2.7
2.6
20.4
49.5
e6/l
0.85
36
342
17
190
0.89
0.13
1.1
1.1
—
—
—
0
0
15
132
1.15
0.13
1.8
2.8
—
—
—
0
0
44
415
1.07
0.12
4.5
3.9
90.8
95.5
%
0.66
44
410
15
168
0.88
0.12
1.5
1.4
—
—
—
0
0
31
289
1.08
0.11
1.8
1.6
—
—
—
0
0
43
408
1.07
0.10
2.8
2.5
0.2
0.4
e6/l
1.02
33
298
25
232
1.09
0.10
3.1
2.4
0.6
0.7
ug/l
0.51
14
121
5
44
1.14
0.10
1.0
1.2
—
—
—
0
0
40
420
0.94
0.09
1.3
1.4
2.3
2.2
g/l
0.15
23
246
42
401
1.06
0.08
2.6
2.3
—
—
—
0
0
6
57
1.05
0.08
5.0
2.4
—
—
—
0
0
6
57
1.05
0.08
8.8
9.4
—
—
—
0
0
6
58
1.03
0.08
2.0
1.4
—
—
—
0
0
11
123
0.89
0.08
1.2
1.4
—
—
—
0
0
85
871
0.96
0.08
5.6
5.7
29.4
29.6
%
0.07
79
825
14
153
0.91
0.07
1.0
1.3
83.9
187.5
iu/ml
—
8
66
165
1631
1.05
0.07
3.9
3.7
5.8
5.7
mmol/l
0.13
160
1518
9
85
1.06
0.07
2.2
2.0
—
—
—
0
0
12
132
0.90
0.07
1.2
1.4
—
—
—
0
0
8
91
0.87
0.07
1.6
2.3
65.4
68.0
g/l
—
8
86
164
1656
0.96
0.06
3.2
3.5
1.3
1.3
mmol/l
0.22
155
1553
43
415
1.04
0.06
2.7
2.5
—
—
—
0
0
12
131
0.91
0.06
1.2
1.4
—
—
—
0
0
12
131
0.91
0.06
1.2
1.4
—
—
—
0
0
172
1734
0.96
0.05
3.5
3.8
4.8
4.8
mmol/l
0.23
165
1639
174
1751
0.97
0.04
4.1
4.1
3.0
2.9
mmol/l
0.56
167
1641
20
210
0.95
0.04
1.5
1.2
—
—
—
0
0
47
459
1.03
0.03
1.2
1.4
1.2
1.7
u/ml
0.48
14
111
11
102
1.08
0.03
1.0
1.1
—
—
—
0
0
10
107
0.93
0.02
3.2
4.3
—
7.4
—
0
7
43
422
1.02
0.01
5.3
4.5
—
—
—
0
0
18
187
0.96
0.01
1.1
1.2
—
—
—
0
0
24
247
0.97
0.01
1.5
1.4
560.0
548.9
titre
—
5
47
36
367
0.98
0.01
1.5
1.6
—
—
—
0
0
80
807
0.99
0.01
5.5
4.2
0.0
0.0
estimate
0.00
14
158
81
817
0.99
0.01
3.8
3.0
0.0
0.0
estimate
0.50
14
149
11
104
1.06
0.00
1.1
1.1
—
—
—
0
0
80
806
0.99
0.00
7.5
8.0
0.0
0.0
e9/l
0.42
58
633
39
384
1.02
0.00
3.9
3.4
1.5
1.8
ug/l
0.32
39
348
14
140
1.00
0.00
2.6
2.5
11.1
10.1
g/l
0.48
14
131
10
101
0.99
0.00
1.0
1.1
—
—
—
0
0
94
936
1.01
0.00
4.9
4.9
6.7
6.4
mmol/l
0.56
86
853
81
807
1.01
0.00
3.7
3.0
0.0
0.0
estimate
0.00
14
152
35
349
1.00
0.00
3.9
3.9
—
—
—
0
0
87
865
1.01
0.00
5.4
5.4
56.4
55.7
%
0.22
81
820
10
100
1.00
0.00
1.2
1.4
—
—
—
0
0
11
114
0.96
0.00
1.5
1.4
—
—
—
0
0
63
630
1.00
0.00
4.6
4.5
37.2
37.1
g/l
0.04
58
592
16
156
1.03
0.00
1.6
1.6
—
—
—
0
0
6
64
0.94
0.00
1.7
1.3
—
—
—
0
0
6
64
0.94
0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
3.3
—
0
7
6
60
1.00
0.00
1.7
1.5
—
—
—
0
0
8
89
0.89
0.00
1.3
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
0.00
1.3
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
7
74
0.94
0.00
1.4
2.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
480.8
—
0
8
5
51
0.98
0.00
2.6
4.5
0.9
1.3
mmol/l
—
5
51
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
136.8
—
0
7
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
34.7
—
128.7
—
0
7
0
5
0.00
0.00
0.0
1.8
—
19.1
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
0.6
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
6
61
0.98
0.00
1.8
3.6
21.0
22.2
s
—
6
56
0
7
0.00
0.00
0.0
1.0
—
156.9
—
0
7
0
9
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
120.9
—
0
7
0
9
0.00
0.00
0.0
5.8
—
1.3
—
0
9
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
8.4
—
11.2
—
0
9
0
7
0.00
0.00
0.0
1.0
—
-4.6
—
0
7
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
1.7
—
0
9
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
8
80
1.00
0.00
2.0
10.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
5.8
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
3.9
—
0
5
0
9
0.00
0.00
0.0
4.3
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: Q17_CLEFT_LIP_AND_PALATE – Cleft lip and palate

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).