No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
625 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
374 |
4. Check minimum number of eventsNone |
374 |
5. Include endpointsNone |
374 |
6. Filter based on genotype QC (FinnGen only) |
374 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF10
Similar endpoints
↥List of similar endpoints to
Caries in Clefts patients
based on the number of shared cases.
Similar with more cases:
- Cleft lip, lip and palate or palate
- Congenital malformations, deformations and chromosomal abnormalities
- Dental caries 1
- Dental caries, including avohilmo
- Dental pulpitis 2, only avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4252 | 2191 | 2056 |
| Only index persons | 3920 | 2029 | 1891 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 24.85 | 25.22 | 24.43 |
| Only index persons | 26.57 | 26.87 | 26.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 374 | 243 | 131 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.06 |
| Median age at first event (years) | 36.37 | 37.58 | 34.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 327
- Matched controls
- 3270
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q35.1
ICD-10 Finland
Cleft hard palate
793.9
116.7
108
*
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
1232.0
97.2
90
*
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
415.4
68.2
66
*
K02.1
ICD-10 Finland
Caries of dentine
17.9
63.9
310
1650
4364
FHL
Pharyngeal tongue plastic
+∞
55.8
52
*
74920
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis unilateralis
543.0
48.7
47
*
7490A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS COMPLETA]
+∞
45.9
43
*
7492A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS UNILATERALIS COMPLETA]
+∞
44.8
42
*
4362
FHL
Nozzle reconstruction
489.4
44.3
43
*
4122
FHL
Tympanostomy (tympanic tube)
18.1
41.0
65
44
Q37.0
ICD-10 Finland
Cleft hard palate with bilateral cleft lip
+∞
37.2
35
*
4361
FHL
Lip plastic or reconstruction due to cleft lip
399.0
36.7
36
*
SBB10
NOMESCO Finland
Teeth copy
7.5
36.7
96
172
Q35.9
ICD-10 Finland
Cleft palate, unspecified
+∞
35.0
33
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
10.5
32.4
66
77
Q35.71
ICD-10 Finland
Submucous cleft palate
+∞
31.8
30
*
EAB30
NOMESCO Finland
Correction of cleft lip
318.7
29.3
29
*
4368
FHL
Closing the fistula of the mouth
+∞
28.6
27
*
7490C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS SUBMUCOSAE]
+∞
28.6
27
*
SAA04
NOMESCO Finland
Special inverstigation of mouth
7.5
27.9
70
114
7490B
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS INCOMPLETA]
+∞
26.4
25
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
8.7
26.2
59
81
74924
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis bilateralis
+∞
25.3
24
*
74929
ICD-8 Finland
Cleft palate and cleft lip, Unspecified
269.7
25.0
25
*
SJX10
NOMESCO Finland
Short check-up visit for orthodontisk therapy
7.7
25.0
61
95
EB1MA
NOMESCO Finland
Cephalometry with X-ray
8.6
24.8
56
77
4365
FHL
Correction of nasal deformity
+∞
24.3
23
*
7492C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS BILATERALIS COMPLETA]
+∞
24.3
23
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
12.2
24.0
44
41
4367
FHL
Bone transfer to the upper jaw
+∞
23.2
22
*
EBB10
NOMESCO Finland
Insertion of dental implant
27.4
22.2
30
12
ZSZ10
NOMESCO Finland
Secondary repair operation
+∞
22.1
21
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.1
21.4
192
1021
WX110
NOMESCO Finland
Local anesthesy
3.9
21.0
278
1944
SFA10
NOMESCO Finland
Fillning on one surface of tooth
3.2
20.9
232
1418
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
3.2
20.0
242
1549
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
31.2
20.0
26
9
SAA03
NOMESCO Finland
Extended examination of mouth
3.0
19.6
192
1061
H65.3
ICD-10 Finland
Chronic mucoid otitis media
8.9
19.5
42
53
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
21.7
19.4
28
14
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
8.2
19.3
44
61
EHC40
NOMESCO Finland
Correction of submucous cleft palate
+∞
18.9
18
*
ECB17
NOMESCO Finland
Operation for cleft gingiva
106.2
18.8
20
*
EEC05
NOMESCO Finland
Le Fort I osteotomy
28.6
18.1
24
9
Q36.9
ICD-10 Finland
Cleft lip, unilateral
189.8
17.7
18
*
74910
ICD-8 Finland
Cleft palate and cleft lip, Cheiloschisis unilateralis
+∞
16.8
16
*
K00.00
ICD-10 Finland
Hypodontia
16.5
16.5
26
17
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
11.7
16.3
30
28
SJD00
NOMESCO Finland
Removal or reattacment of arrow in fixed orthodontisk device
6.8
16.1
41
67
1450
FHL
Otomicroscopy
20.5
15.8
23
12
EHC10
NOMESCO Finland
Plastic repair of oronasal or oroantral fistula of palate
+∞
15.7
15
*
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
40.2
15.6
19
5
SAA02
NOMESCO Finland
Basic examination of mouth
3.0
15.3
267
1952
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
8.5
14.7
32
41
9808
FHL
Bone graft
+∞
14.7
14
*
Q35.3
ICD-10 Finland
Cleft soft palate
156.7
14.6
15
*
4451
FHL
Guitar cutting
4.9
14.5
49
113
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
5.9
14.0
40
76
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
18.6
14.0
21
12
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.6
13.8
141
746
DLW00
NOMESCO Finland
Correction of cleft nose
+∞
13.6
13
*
EBA00
NOMESCO Finland
Extraction of tooth
2.5
13.6
147
802
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
13.0
12.8
22
18
SJC50
NOMESCO Finland
Removal of orthodontisk device with at least 7 brackets
6.3
12.8
34
59
SJD20
NOMESCO Finland
Attachment of modifiable arrow of fixed orthodontisk device
6.7
12.6
32
52
EB1AA
NOMESCO Finland
Tooth X-ray examination
2.4
12.6
207
1375
EBB15
NOMESCO Finland
Insertion of dental implant abutment
21.1
12.6
18
9
4366
FHL
Upper jaw scar repair surgery
+∞
12.6
12
*
H66.9
ICD-10 Finland
Otitis media, unspecified
3.7
11.8
53
161
SAA01
NOMESCO Finland
Simple examination of mouth
2.7
11.7
269
2080
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
2.3
11.6
149
865
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
4.5
11.5
41
100
Q37.99
ICD-10 Finland
Cleft palate with cleft lip NOS
+∞
11.5
11
*
74912
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis unilateralis
+∞
11.5
11
*
SJD30
NOMESCO Finland
Demanding attachment of arrow to fixed orthodontisk device
7.3
11.4
27
40
SJA01
NOMESCO Finland
Estimation of need for orthodontic care
36.4
11.4
14
*
SPC20
NOMESCO Finland
Attachment of crone of tooth to implant
26.1
11.2
15
6
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
2.2
10.8
220
1565
4204
FHL
Molding of the cartilaginous part of the nose
+∞
10.5
10
*
4347
FHL
Osteotomy of the upper jaw
+∞
10.5
10
*
SJB00
NOMESCO Finland
Fitting of loose orthodontic device with user information
4.9
10.4
34
76
H66.0
ICD-10 Finland
Acute suppurative otitis media
3.0
9.7
58
216
DLD20
NOMESCO Finland
Rhinoplasty
56.7
9.7
11
*
UDC00
NOMESCO Finland
Ear microscopy
4.3
9.7
36
92
SJD40
NOMESCO Finland
Fixation of ready made palatinal or lingual arrow
5.0
9.5
30
65
SJA04
NOMESCO Finland
Very demanding plan for orthodontic care
31.0
9.5
12
*
Q37.90
ICD-10 Finland
Unspecified cheft palate with cleft lip, unilateral
+∞
9.4
9
*
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.5
9.4
84
399
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
10.5
9.1
17
17
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
24.8
9.0
12
5
K07.14
ICD-10 Finland
Retrognaty, maxillary
13.0
9.0
15
12
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
9.9
8.9
17
18
SPF10
NOMESCO Finland
Demanding repatation of teeth prosthesis
51.4
8.7
10
*
WX290
NOMESCO Finland
Other blockade of nerve
2.0
8.6
190
1333
SJB60
NOMESCO Finland
External device grinding and adaptation
5.5
8.5
24
46
SXC05
NOMESCO Finland
Other oral or dental procedure
3.2
8.5
44
150
SJD10
NOMESCO Finland
Attachment of arrow to fixed orthodontisk device
4.5
8.4
29
69
Z01.2
ICD-10 Finland
Dental examination
2.0
8.4
169
1143
4203
FHL
Mobilization and repositioning of the external pyramid
+∞
8.4
8
*
Q35.70
ICD-10 Finland
Cleft uvula
+∞
8.4
8
*
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
15.0
8.3
13
9
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
22.7
8.1
11
5
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
22.7
8.1
11
5
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.8
7.8
51
201
SPF20
NOMESCO Finland
Temporary soling for filling
25.7
7.6
10
*
R4130
NOMESCO Finland
Speech therapy
8.7
7.4
15
18
7491A
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOSCHISIS UNILATERALIS COMPLETA]
+∞
7.3
7
*
Q35
ICD-10 Finland
Cleft palate
+∞
7.3
7
*
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
2.0
7.3
133
849
SJC40
NOMESCO Finland
Removal of orthodontisk device with at most 6 brackets
4.5
7.1
24
57
ZXA10
NOMESCO Finland
Bilateral
2.5
7.0
59
269
EBA10
NOMESCO Finland
Surgical removal of tooth
2.3
7.0
72
363
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
5.0
7.0
21
44
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
11.3
6.8
12
11
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
11.3
6.8
12
11
SJA03
NOMESCO Finland
Demanding plan for orthodontic care
23.1
6.7
9
*
WZA90
NOMESCO Finland
Other doctors statement
2.0
6.7
92
526
DCD00
NOMESCO Finland
Myringoplasty
12.6
6.6
11
9
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
5.9
6.5
17
30
ENC80
NOMESCO Finland
Plastic operation of soft palate for voice distubance
71.2
6.4
7
*
ZZG00
NOMESCO Finland
Graft of cartilage
71.2
6.4
7
*
SPB20
NOMESCO Finland
Temporary bridge between two or more teeth
14.7
6.4
10
7
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
18.4
6.3
9
5
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
18.4
6.3
9
5
SPF30
NOMESCO Finland
Soling for prothesis
18.4
6.3
9
5
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
18.4
6.3
9
5
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
6.2
87
500
K01.0
ICD-10 Finland
Embedded teeth
5.1
6.1
18
37
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
4.1
6.1
22
56
EBA15
NOMESCO Finland
Extraction of large number of teeth
5.7
6.1
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
320
2911
1.69
3.18
12.9
9.9
139.7
139.6
mmol/l
0.16
314
2824
22
100
2.27
3.06
20.0
9.9
0.8
0.7
%
0.25
22
100
22
101
2.25
2.99
20.0
9.8
1.4
1.6
%
0.33
22
101
22
102
2.23
2.93
20.0
9.8
96.0
94.5
%
1.38
22
102
10
30
3.40
2.92
1.4
1.4
—
—
—
0
0
13
48
2.77
2.74
1.1
1.2
—
—
—
0
0
31
169
1.91
2.72
20.9
8.8
1.0
1.3
mmol/l
1.75
31
160
318
2923
1.59
2.62
13.1
9.9
3.9
3.9
mmol/l
0.04
310
2827
16
75
2.18
2.11
1.1
1.1
—
—
—
0
0
45
306
1.53
1.84
2.8
2.3
2.3
2.4
g/l
0.72
40
282
35
523
0.64
1.80
1.3
1.3
14.2
9.2
u/ml
0.15
18
213
107
862
1.34
1.73
3.5
2.9
—
—
—
0
0
42
288
1.52
1.66
1.7
1.5
970.1
1218.5
nmol/l
1.11
32
235
174
1510
1.28
1.61
6.7
4.7
6.5
6.4
mmol/l
0.45
156
1351
37
533
0.66
1.61
1.2
1.3
18.3
24.1
iu/ml
0.29
15
171
8
32
2.53
1.60
1.3
1.3
—
—
—
0
0
163
1413
1.27
1.50
3.6
2.9
0.0
0.0
estimate
0.00
33
289
53
390
1.42
1.49
3.3
2.3
1.4
0.8
e6/l
0.79
30
208
11
52
2.15
1.46
6.5
5.6
—
5348.0
—
0
5
18
103
1.79
1.43
13.1
7.5
122.6
131.5
g/l
0.70
18
103
54
402
1.40
1.43
3.5
3.1
36.0
599.6
ng/l
1.17
30
233
17
96
1.81
1.41
2.2
1.5
—
—
—
0
0
50
376
1.38
1.26
3.3
2.4
3.7
2.7
e6/l
0.36
28
193
17
101
1.72
1.22
2.8
2.7
72.5
103.8
ng/l
0.35
12
90
84
688
1.28
1.19
3.2
2.6
0.4
0.3
e6/l
0.05
68
509
162
1434
1.23
1.17
3.7
3.0
0.0
0.0
estimate
0.50
31
286
160
1415
1.23
1.16
5.2
4.1
0.0
0.0
estimate
0.50
31
300
5
20
2.52
1.15
1.4
1.3
64.6
92.1
u/l
—
5
14
287
2702
1.27
1.14
10.0
8.2
95.0
95.6
ml/min/173m2
0.16
234
2162
29
201
1.48
1.14
2.2
2.6
—
—
—
0
0
292
2762
1.26
1.07
4.6
4.5
1.8
1.7
mu/l
0.51
281
2614
24
164
1.50
1.02
22.5
9.8
25.4
24.8
mmol/l
0.46
24
164
10
172
0.57
0.96
1.4
1.7
2.8
2.5
mg/l
—
5
113
113
982
1.22
0.95
10.7
6.9
1.2
1.2
mmol/l
1.03
105
912
11
181
0.60
0.90
1.5
1.7
—
—
—
0
0
10
56
1.81
0.88
1.1
1.1
59.6
141.3
iu/ml
—
5
15
74
622
1.24
0.86
2.2
2.4
3.0
2.7
mg/l
0.37
64
537
31
408
0.74
0.85
1.8
1.5
—
—
—
0
0
249
2344
1.19
0.82
3.9
4.0
14.3
14.4
pmol/l
0.43
235
2190
21
292
0.70
0.81
1.1
1.3
204.2
176.7
iu/ml
—
9
116
0
24
0.00
0.79
0.0
1.0
—
1.1
—
0
7
5
98
0.50
0.79
1.2
1.1
—
—
—
0
0
31
235
1.35
0.79
6.8
5.7
—
—
—
0
0
5
99
0.50
0.78
1.2
1.1
—
—
—
0
0
0
27
0.00
0.77
0.0
1.0
—
—
—
0
0
95
828
1.20
0.77
2.0
1.7
97.2
95.6
pmol/l
0.13
52
434
24
175
1.40
0.77
11.0
9.7
7.9
6.8
mmol/l
0.41
24
170
21
150
1.42
0.75
1.7
1.6
—
—
—
0
0
34
432
0.77
0.75
1.4
1.5
—
—
—
0
0
9
54
1.68
0.75
2.3
2.0
—
—
—
0
0
5
24
2.10
0.75
1.0
2.6
—
—
—
0
0
7
38
1.86
0.74
2.3
1.2
—
—
—
0
0
289
2768
1.19
0.72
15.0
12.2
13.3
13.3
%
0.41
284
2725
16
109
1.49
0.72
1.6
1.4
107.8
194.0
u/ml
1.91
11
60
18
127
1.44
0.69
1.1
1.4
—
—
—
0
0
5
27
1.86
0.68
1.2
2.4
—
—
—
0
0
123
1111
1.16
0.65
3.7
2.9
—
—
—
0
0
21
155
1.38
0.64
3.2
5.5
1.0
0.9
mmol/l
0.06
13
110
5
29
1.73
0.64
1.2
2.4
11.6
9.3
%
—
5
23
47
390
1.23
0.63
1.7
1.5
466.1
38418510.0
pmol/l
0.80
40
354
6
101
0.59
0.63
1.3
2.1
—
—
—
0
0
16
113
1.43
0.62
1.6
1.4
—
—
—
0
0
125
1135
1.15
0.62
2.8
2.5
68.4
72.2
nmol/l
0.93
119
1054
75
655
1.18
0.61
2.5
2.0
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.0
—
94.3
—
0
12
22
287
0.75
0.60
1.4
1.4
—
—
—
0
0
11
161
0.67
0.58
1.4
1.4
—
—
—
0
0
8
54
1.49
0.57
2.9
5.0
358.0
370.3
umol/l
—
8
49
14
98
1.45
0.57
1.5
1.5
0.0
0.0
iu/ml
—
5
20
159
1476
1.13
0.56
3.2
2.9
76.3
87.5
ug/l
0.55
152
1394
79
698
1.17
0.56
1.5
1.5
—
—
—
0
0
278
2678
1.15
0.54
3.4
3.3
5.8
5.6
mmol/l
0.91
266
2493
72
635
1.17
0.52
4.0
3.1
1.0
1.0
kg/l
0.64
11
88
120
1099
1.14
0.52
9.7
7.5
1.2
1.2
mmol/l
1.14
107
948
7
46
1.53
0.48
1.6
1.4
—
—
—
0
0
20
254
0.78
0.47
1.5
1.5
—
—
—
0
0
109
999
1.13
0.47
1.7
1.7
—
—
—
0
0
28
229
1.24
0.45
2.0
1.7
—
—
—
0
0
10
69
1.46
0.44
8.7
1.8
0.5
0.8
nmol/l
—
10
59
252
2428
1.12
0.43
4.7
4.1
38.6
37.7
mmol/mol
0.56
243
2305
39
334
1.19
0.41
1.9
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
3.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.7
—
—
—
0
0
0
15
0.00
0.41
0.0
3.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
59
524
1.15
0.41
1.9
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.8
—
16.1
—
0
6
23
187
1.25
0.40
1.3
1.3
265.4
260.9
miu/ml
0.02
13
96
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
19
0.00
0.39
0.0
1.0
—
134.0
—
0
19
0
19
0.00
0.39
0.0
1.0
—
103.7
—
0
11
82
749
1.12
0.38
3.6
3.1
0.0
0.0
estimate
0.80
32
295
27
226
1.21
0.37
1.3
1.3
—
—
—
0
0
314
3075
1.13
0.36
14.8
10.7
39.9
40.9
%
1.38
263
2609
16
126
1.28
0.36
1.4
1.8
—
—
—
0
0
27
227
1.20
0.35
2.0
1.6
—
—
—
0
0
17
211
0.80
0.35
3.6
3.7
4.4
4.8
pmol/l
1.29
17
189
179
1709
1.09
0.34
9.3
8.9
4.2
3.9
e9/l
0.90
154
1496
37
322
1.17
0.34
2.9
3.8
5.0
8.3
umol/l
1.32
31
273
77
707
1.11
0.33
1.5
1.6
1.3
1.4
mmol/l
0.07
69
620
84
777
1.10
0.31
2.8
2.6
23.4
29.2
ng/l
0.25
42
349
19
227
0.83
0.29
2.4
2.2
—
22.9
—
0
16
295
2889
1.10
0.29
3.7
3.6
2.9
2.9
mmol/l
0.15
282
2724
12
94
1.29
0.28
2.4
1.5
—
—
—
0
0
10
126
0.79
0.24
1.9
2.1
32.5
39.7
u/l
—
10
116
10
78
1.29
0.24
7.2
4.1
63.9
52.6
%
—
10
78
35
313
1.13
0.24
3.4
2.9
18.5
23.5
%
1.03
12
95
327
3227
1.11
0.23
9.6
8.2
25.6
27.7
u/l
1.13
319
3138
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
19
220
0.86
0.22
1.3
1.4
265.9
313.4
mu/l
0.62
19
195
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
108.9
—
0
12
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
3.6
—
49.3
—
0
12
0
12
0.00
0.21
0.0
1.2
—
199.1
—
0
12
0
12
0.00
0.21
0.0
1.1
—
25.8
—
0
12
10
80
1.26
0.20
6.7
5.1
25.5
24.8
mmol/l
—
10
80
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
0.3
—
0
14
134
1289
1.06
0.20
5.8
5.8
9.2
10.4
umol/l
1.63
126
1226
6
51
1.18
0.19
13.0
4.1
59.2
57.9
%
—
6
51
209
2040
1.06
0.18
7.8
6.5
77.0
77.5
u/l
0.05
198
1923
82
779
1.07
0.18
2.5
2.9
2.4
2.4
mmol/l
0.53
69
710
26
287
0.90
0.16
1.7
2.3
5723.8
4156.9
u/l
—
7
127
11
92
1.20
0.16
4.6
5.7
9.4
9.3
kpa
0.13
11
85
42
390
1.09
0.16
6.3
2.9
1424.6
582.5
ng/l
0.50
33
305
139
1349
1.05
0.15
4.2
3.9
—
—
—
0
0
12
139
0.86
0.14
1.4
1.4
—
—
—
0
0
21
232
0.90
0.13
1.4
1.4
—
—
—
0
0
21
232
0.90
0.13
1.4
1.4
—
—
—
0
0
14
159
0.88
0.13
2.9
4.5
228.4
33.9
ug/l
—
8
124
21
231
0.90
0.12
1.4
1.4
—
—
—
0
0
21
231
0.90
0.12
1.4
1.4
—
—
—
0
0
15
168
0.89
0.12
4.7
2.1
52.5
46.2
u/ml
0.07
15
160
290
2869
1.05
0.12
3.4
3.4
4.7
4.7
mmol/l
0.18
277
2724
76
789
0.95
0.11
1.9
2.1
—
—
—
0
0
11
96
1.15
0.10
1.2
1.5
—
266.7
—
0
6
5
46
1.09
0.09
1.0
1.2
—
—
—
0
0
10
87
1.15
0.09
1.2
2.0
—
—
—
0
0
13
116
1.13
0.09
1.4
1.3
—
—
—
0
0
48
502
0.95
0.09
2.2
1.8
1.5
1.4
%
0.29
42
466
84
865
0.96
0.09
2.1
2.2
—
—
—
0
0
103
1004
1.04
0.09
4.2
3.1
121.3
32.1
u/l
0.46
98
958
5
63
0.79
0.08
1.4
1.6
—
—
—
0
0
5
64
0.78
0.08
1.2
1.6
—
—
—
0
0
13
117
1.12
0.08
3.8
2.7
0.3
0.1
e6/l
0.60
13
112
5
65
0.77
0.08
1.4
1.1
—
—
—
0
0
210
2126
0.97
0.08
4.0
3.7
9.7
8.4
mm/h
0.79
203
1990
7
82
0.85
0.07
1.6
1.9
—
—
—
0
0
288
2860
1.03
0.06
3.3
3.4
1.4
1.5
mmol/l
0.57
276
2708
20
213
0.94
0.06
2.5
1.6
—
—
—
0
0
37
355
1.05
0.06
2.5
2.3
2.4
2.4
mmol/l
0.76
32
310
10
91
1.10
0.04
1.8
1.3
63.9
52.6
pmol/l
—
10
86
307
3083
0.98
0.03
12.3
10.0
19.4
20.2
mg/l
0.17
228
2294
16
151
1.06
0.03
1.4
1.4
—
—
—
0
0
277
2758
1.02
0.03
4.0
3.8
—
—
—
0
0
64
651
0.98
0.03
2.7
2.1
219.7
279.3
u/l
0.19
58
628
18
188
0.96
0.02
2.8
2.0
—
—
—
0
0
275
2741
1.01
0.01
3.0
3.1
1.3
1.2
mmol/l
0.37
264
2594
25
243
1.03
0.01
2.7
2.1
0.6
0.7
ug/l
0.46
15
110
80
793
1.01
0.01
5.0
2.5
61.1
54.7
u/l
0.67
74
748
223
2223
1.01
0.01
3.2
3.1
34.4
35.7
u/l
0.13
213
2147
13
124
1.05
0.00
1.3
1.2
—
—
—
0
0
20
206
0.97
0.00
1.5
1.5
—
—
—
0
0
23
236
0.97
0.00
1.0
1.0
—
—
—
0
0
10
101
0.99
0.00
1.2
1.3
—
—
—
0
0
13
133
0.98
0.00
1.3
1.4
—
—
—
0
0
11
115
0.96
0.00
4.8
3.6
95.8
95.2
%
0.04
11
110
88
885
0.99
0.00
1.2
1.4
0.8
1.1
u/ml
0.73
26
228
62
616
1.01
0.00
1.9
2.1
0.9
1.0
mg/l
0.14
51
449
42
416
1.01
0.00
1.7
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
6
63
0.95
0.00
1.2
1.6
—
—
—
0
0
5
55
0.91
0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
8
89
0.90
0.00
1.6
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
0.00
1.2
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
0.00
1.2
2.6
60.8
3.2
u/ml
—
5
45
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CLEFT_AND_CARIES and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CLEFT_AND_CARIES | 1.835 [1.26, 2.67] | 0.002 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 1798 males with Q17_CLEFT_AND_CARIES died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CLEFT_AND_CARIES.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.411% |
| 5 | No data | 2.223% |
| 10 | No data | 5.802% |
| 15 | No data | 10.596% |
| 20 | No data | 17.778% |
Relationships between endpoints
↥Index endpoint: Q17_CLEFT_AND_CARIES – Caries in Clefts patients
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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