No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditions
|
625 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
402 |
4. Check minimum number of eventsNone |
402 |
5. Include endpointsNone |
402 |
6. Filter based on genotype QC (FinnGen only) |
384 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF10
Similar endpoints
↥List of similar endpoints to
Caries in Clefts patients
based on the number of shared cases.
Similar with more cases:
- Cleft lip, lip and palate or palate
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities
- Dental caries, including avohilmo
- Diseases of pulp and periapical tissues and dental caries
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4252 | 2191 | 2056 |
| Only index persons | 3920 | 2029 | 1891 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 24.85 | 25.22 | 24.43 |
| Only index persons | 26.57 | 26.87 | 26.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 384 | 245 | 139 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.06 |
| Median age at first event (years) | 36.73 | 37.58 | 35.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 402
- Matched controls
- 4020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q35.1
ICD-10 Finland
Cleft hard palate
982.9
144.5
133
*
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
+∞
114.1
104
*
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
572.2
94.5
90
*
4122
FHL
Tympanostomy (tympanic tube)
18.0
91.2
79
54
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
9.8
65.2
84
105
74920
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis unilateralis
686.3
61.5
59
*
SBB10
NOMESCO Finland
Dental impressions
6.5
60.7
125
262
4364
FHL
Pharyngeal tongue plastic
+∞
59.9
56
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
14.0
58.6
57
47
SAA04
NOMESCO Finland
Special examination of mouth
8.1
58.3
89
136
7490A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS COMPLETA]
+∞
56.6
53
*
4362
FHL
Nozzle reconstruction
618.8
56.0
54
*
EB1MA
NOMESCO Finland
Cephalometry with X-ray
9.2
53.2
71
92
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
7.8
51.5
80
124
7492A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS UNILATERALIS COMPLETA]
553.2
50.6
49
*
K02.1
ICD-10 Finland
Caries of dentine
11.2
48.3
375
2221
4361
FHL
Lip plastic or reconstruction due to cleft lip
+∞
47.9
45
*
Q37.0
ICD-10 Finland
Cleft hard palate with bilateral cleft lip
+∞
45.7
43
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
8.3
42.3
60
83
Q35.9
ICD-10 Finland
Cleft palate, unspecified
451.8
41.9
41
*
EAB30
NOMESCO Finland
Correction of cleft lip
439.5
40.9
40
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
13.8
40.6
39
31
Q35.71
ICD-10 Finland
Submucous cleft palate
414.9
38.7
38
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
5.9
37.1
75
150
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
7.0
36.8
61
100
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
8.3
32.5
45
60
K00.00
ICD-10 Finland
Hypodontia
12.3
32.2
33
29
ECB17
NOMESCO Finland
Operation of gingival cleft
+∞
31.7
30
*
4368
FHL
Closing the fistula of the mouth
+∞
31.7
30
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.5
31.5
55
95
7490B
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS INCOMPLETA]
+∞
30.6
29
*
7490C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS SUBMUCOSAE]
+∞
30.6
29
*
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
6.3
29.7
54
97
74929
ICD-8 Finland
Cleft palate and cleft lip, Unspecified
+∞
28.5
27
*
4365
FHL
Correction of nasal deformity
+∞
28.5
27
*
EEC05
NOMESCO Finland
Le Fort I osteotomy
83.9
28.2
31
*
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
6.7
27.4
46
76
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
8.6
26.4
35
44
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.1
26.4
244
1346
Q36.9
ICD-10 Finland
Cleft lip, unilateral
277.5
26.0
26
*
4451
FHL
Guitar cutting
5.4
25.9
55
114
74924
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis bilateralis
+∞
25.3
24
*
ZSZ10
NOMESCO Finland
Secondary repair operation
138.6
24.9
26
*
7492C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS BILATERALIS COMPLETA]
+∞
24.2
23
*
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
6.4
24.0
42
72
EBB10
NOMESCO Finland
Insertion of dental implant
20.0
23.5
35
19
4367
FHL
Bone transfer to the upper jaw
243.3
22.9
23
*
UDC00
NOMESCO Finland
Ear microscopy
4.8
22.8
56
131
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
7.8
22.4
32
44
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
5.5
21.9
45
90
EHC40
NOMESCO Finland
Repair of submucous cleft palate
232.1
21.8
22
*
SAA03
NOMESCO Finland
Extended examination of mouth
2.7
21.0
242
1437
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
30.8
19.9
26
9
WZC00
NOMESCO Finland
Treatment plan or consultation
2.6
19.7
190
1025
ZXD10
NOMESCO Finland
Scheduled procedure
2.6
18.7
174
917
EHC10
NOMESCO Finland
Plastic repair of oronasal or oroantral fistula of palate
198.9
18.7
19
*
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
17.3
18.6
29
18
WX110
NOMESCO Finland
Infiltration anesthesia
3.5
18.3
345
2555
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
19.2
18.0
27
15
74910
ICD-8 Finland
Cleft palate and cleft lip, Cheiloschisis unilateralis
187.9
17.7
18
*
Q35.3
ICD-10 Finland
Cleft soft palate
187.9
17.7
18
*
EBB15
NOMESCO Finland
Insertion of dental implant abutment
30.4
17.6
23
8
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.3
17.4
75
261
DLW00
NOMESCO Finland
Correction of cleft nose
177.0
16.6
17
*
9808
FHL
Bone graft
177.0
16.6
17
*
SFA10
NOMESCO Finland
One-surface restoration
2.5
16.5
281
1917
Z2221
NOMESCO Finland
Medical doctor
2.5
16.1
147
757
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
4.6
16.1
40
94
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
5.4
16.0
33
66
1450
FHL
Otomicroscopy
18.1
15.8
24
14
H66.9
ICD-10 Finland
Otitis media, unspecified
3.2
15.7
72
259
Q37.99
ICD-10 Finland
Cleft palate with cleft lip NOS
+∞
15.7
15
*
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
4.6
15.6
39
92
SFA20
NOMESCO Finland
Two-surface restoration
2.5
15.3
291
2052
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
6.2
15.0
26
44
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
13.9
14.9
25
19
ZXB10
NOMESCO Finland
Medial
26.2
14.8
20
8
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
5.4
14.8
30
59
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.9
14.8
81
322
Q37.90
ICD-10 Finland
Unspecified cheft palate with cleft lip, unilateral
+∞
14.7
14
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
3.9
14.5
46
130
EBA00
NOMESCO Finland
Extraction of tooth
2.3
14.4
193
1162
Z01.2
ICD-10 Finland
Dental examination
2.2
13.8
242
1618
4366
FHL
Upper jaw scar repair surgery
+∞
13.6
13
*
ENC80
NOMESCO Finland
Plastic operation of soft palate for voice distubance
+∞
13.6
13
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
13.3
150
836
SAA02
NOMESCO Finland
Basic examination of mouth
2.8
13.3
341
2667
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
41.6
13.2
16
*
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
15.7
13.2
21
14
SXC05
NOMESCO Finland
Other oral or dental procedure
3.0
13.0
62
227
ZXA10
NOMESCO Finland
Bilateral
2.7
12.6
79
336
K07.14
ICD-10 Finland
Retrognaty, maxillary
20.9
12.6
18
9
74912
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis unilateralis
+∞
12.6
12
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.2
12.2
33
83
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
4.3
11.9
32
80
SJX20
NOMESCO Finland
Orthodontic treatment/control appointment
4.6
11.9
29
67
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
31.1
11.7
15
5
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
23.7
11.7
16
7
R4130
NOMESCO Finland
Speech therapy
5.9
11.6
21
37
SAA01
NOMESCO Finland
Simple examination of mouth
2.7
11.6
342
2739
4347
FHL
Osteotomy of the upper jaw
+∞
11.5
11
*
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
11.0
11.4
21
20
SDA03
NOMESCO Finland
Periodontal treatment
2.1
11.4
197
1278
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
25.9
11.2
15
6
DCD00
NOMESCO Finland
Myringoplasty
14.7
10.6
17
12
4204
FHL
Molding of the cartilaginous part of the nose
112.8
10.5
11
*
Q35.70
ICD-10 Finland
Cleft uvula
+∞
10.5
10
*
SPC20
NOMESCO Finland
Implant borne crown
16.6
10.4
16
10
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
2.0
10.2
248
1788
R1260
NOMESCO Finland
Evaluation of communicative skills
11.7
10.2
18
16
DLD20
NOMESCO Finland
Rhinoplasty
26.8
9.9
13
5
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
20.7
9.9
14
7
ZZG00
NOMESCO Finland
Graft of cartilage
102.3
9.5
10
*
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
8.4
9.5
20
25
SPF20
NOMESCO Finland
Temporary relining of dentures
30.8
9.5
12
*
ZSZ00
NOMESCO Finland
Primary repair operation
+∞
9.4
9
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.1
9.4
40
137
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
19.1
9.0
13
7
SPF10
NOMESCO Finland
Demanding reparation of dental prosthesis
24.7
9.0
12
5
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
12.9
8.9
15
12
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
8.9
108
606
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
14.4
8.7
14
10
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.9
8.7
19
40
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
8.7
53
221
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.0
8.5
105
592
4203
FHL
Mobilization and repositioning of the external pyramid
91.9
8.4
9
*
Q35
ICD-10 Finland
Cleft palate
91.9
8.4
9
*
SJC40
NOMESCO Finland
Removal of fixed orthodontic appliance with at most 6 brackets
3.4
8.4
31
97
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
3.4
8.4
30
92
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.9
8.4
269
2068
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
4.0
8.4
24
63
Q36.0
ICD-10 Finland
Cleft lip, bilateral
+∞
8.4
8
*
EB1WA, ,
NOMESCO Finland
11.1
8.4
15
14
ZXE00
NOMESCO Finland
One hour or less
1.9
8.3
165
1089
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
6.5
8.1
20
32
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
34.1
8.1
10
*
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
22.6
8.1
11
5
J01DA08
ATC
[U] cefaclor
2.2
7.9
79
409
SFA30
NOMESCO Finland
Three-surface restoration
1.8
7.8
167
1125
SPB10
NOMESCO Finland
Manufacture of a temporary crown to tooth at the dental office
15.4
7.8
12
8
DLD00
NOMESCO Finland
Reconstruction of cartilage of nose
45.9
7.7
9
*
SPB20
NOMESCO Finland
Temporary bridge
18.8
7.6
11
6
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
25.6
7.6
10
*
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
25.6
7.6
10
*
4741B
ICD-9 Finland
Chronic disease of tonsils and adenoids, Hypertrophy of tonsils and adenoids[HYPERTROPHIA TONSILLAE PHARYNGICAE]
4.4
7.6
19
45
7491F
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOGNATOSCHISIS UNILATERALIS INCOMPLETA]
+∞
7.3
7
*
7491B
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOSCHISIS UNILATERALIS INCOMPLETA]
+∞
7.3
7
*
Q37.3
ICD-10 Finland
Cleft soft palate with unilateral cleft lip
+∞
7.3
7
*
7491A
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOSCHISIS UNILATERALIS COMPLETA]
+∞
7.3
7
*
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
3.7
7.3
23
65
H66
ICD-10 Finland
Suppurative and unspecified otitis media
3.6
7.2
24
70
H74.1
ICD-10 Finland
Adhesive middle ear disease
30.6
7.2
9
*
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
10.3
7.1
13
13
WX290
NOMESCO Finland
Other blockage of nerve
1.8
6.9
239
1832
WZA90
NOMESCO Finland
Other medical or dental certificate
1.9
6.8
116
721
DFF00
NOMESCO Finland
Pure tone audiometry
2.8
6.8
35
133
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
40.8
6.8
8
*
K01.0
ICD-10 Finland
Embedded teeth
3.8
6.7
20
54
H65.2
ICD-10 Finland
Chronic serous otitis media
6.6
6.7
16
25
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
12.5
6.6
11
9
4141
FHL
Myringoplasty (also for reasons other than inflammation)
70.9
6.4
7
*
R49.2
ICD-10 Finland
Hypernasality and hyponasality
70.9
6.4
7
*
DLD10
NOMESCO Finland
Reconstruction of cartilage and bone of nose
70.9
6.4
7
*
SPA10
NOMESCO Finland
Setting attachments on tooth or implanted bracket or imblant based structures
+∞
6.3
6
*
Q35.7
ICD-10 Finland
Cleft uvula
+∞
6.3
6
*
EBA10
NOMESCO Finland
Operative extraction of tooth
1.9
6.3
92
545
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
6.4
6.2
15
24
SPF30
NOMESCO Finland
Relining of denture
12.8
6.1
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
12
34
3.61
3.22
1.4
1.4
—
—
—
0
0
343
3145
1.62
2.95
12.6
10.3
139.64
139.61
mmol/l
0.11
337
3048
13
51
2.60
2.47
1.1
1.2
—
—
—
0
0
341
3156
1.53
2.44
12.8
10.4
3.92
3.92
mmol/l
0.07
333
3050
41
254
1.68
2.38
11.0
9.2
104.78
104.69
mmol/l
0.05
41
254
22
115
1.97
2.20
20.0
12.0
0.80
0.73
%
0.29
22
115
22
115
1.97
2.20
20.0
11.9
1.41
1.53
%
0.24
22
115
119
940
1.38
2.19
3.5
3.1
—
—
—
0
0
22
117
1.93
2.10
20.0
11.9
96.04
94.62
%
1.38
22
117
51
347
1.54
2.05
2.6
2.5
2.33
2.44
g/l
0.57
46
320
31
186
1.72
2.04
20.9
10.5
1.03
1.34
mmol/l
1.94
31
181
17
83
2.09
2.04
1.1
1.1
—
—
—
0
0
61
432
1.49
2.04
3.2
2.5
1.24
0.75
e6/l
0.67
34
229
179
1528
1.31
1.91
3.6
3.0
0.00
0.00
estimate
-0.00
37
323
9
35
2.61
1.81
1.2
1.3
—
—
—
0
0
38
558
0.65
1.79
1.3
1.3
12.94
8.79
u/ml
0.14
20
225
57
418
1.42
1.61
3.2
2.6
3.34
2.99
e6/l
0.12
31
214
94
752
1.33
1.56
3.3
2.8
0.38
0.31
e6/l
0.15
75
557
176
1529
1.27
1.56
5.2
4.1
0.00
0.00
estimate
0.50
35
321
178
1550
1.27
1.54
3.7
3.0
0.00
0.01
estimate
0.50
35
305
12
58
2.10
1.50
6.1
5.6
—
4465.33
—
0
6
41
569
0.69
1.46
1.3
1.3
21.01
23.09
iu/ml
0.09
16
184
32
214
1.54
1.43
2.3
2.6
—
—
—
0
0
316
2969
1.30
1.36
4.5
4.5
1.79
1.76
mu/l
0.21
305
2809
390
3802
1.86
1.32
18.4
15.0
40.49
40.90
%
0.69
372
3637
84
680
1.30
1.28
2.4
2.4
2.94
2.66
mg/l
0.39
74
585
44
322
1.41
1.28
1.8
1.5
954.72
1234.62
nmol/l
1.37
33
262
390
3806
1.83
1.25
17.2
14.9
4.63
4.60
e12/l
0.75
379
3713
184
1638
1.23
1.24
6.5
4.9
6.51
6.38
mmol/l
0.31
165
1471
389
3800
1.73
1.14
17.4
14.9
269.70
259.07
e9/l
2.73
379
3712
17
105
1.65
1.08
2.2
1.5
—
—
—
0
0
18
113
1.62
1.07
13.1
7.6
122.56
131.04
g/l
0.66
18
113
5
107
0.46
1.02
1.2
1.1
—
—
—
0
0
5
108
0.46
1.02
1.2
1.1
—
—
—
0
0
269
2520
1.20
0.98
3.8
4.0
14.35
14.44
pmol/l
0.24
254
2350
11
185
0.58
0.97
1.4
1.7
2.84
3.01
mg/l
—
5
125
306
2908
1.22
0.93
10.0
8.4
94.86
95.18
ml/min/173m2
0.09
249
2323
55
441
1.29
0.93
3.5
3.1
124.52
601.89
ng/l
1.00
31
262
22
312
0.69
0.92
1.1
1.3
204.22
174.61
iu/ml
—
9
127
16
103
1.58
0.89
1.6
1.4
0.00
0.01
iu/ml
—
6
20
15
96
1.58
0.85
15.0
7.1
0.60
0.64
%
0.23
15
96
8
45
1.79
0.84
2.1
1.3
—
—
—
0
0
71
595
1.23
0.84
3.9
4.1
8.55
10.41
mg/mmol
0.22
53
395
104
906
1.20
0.84
2.0
1.7
97.02
96.36
pmol/l
0.05
55
469
121
1070
1.19
0.83
10.5
7.3
1.21
1.22
mmol/l
0.88
114
1001
53
430
1.27
0.82
1.8
1.5
473.00
34694307.37
pmol/l
0.80
45
392
17
114
1.51
0.81
2.8
3.0
72.50
126.80
ng/l
0.63
12
103
23
165
1.42
0.79
1.7
1.6
—
—
—
0
0
6
33
1.83
0.79
1.0
1.4
217.83
407.64
pmol/l
—
6
33
0
26
0.00
0.78
0.0
1.1
—
1.05
—
0
8
34
435
0.76
0.78
1.8
1.5
—
—
—
0
0
12
185
0.64
0.77
1.6
1.7
—
—
—
0
0
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
19
133
1.45
0.75
1.3
1.4
—
—
—
0
0
33
255
1.32
0.74
6.6
5.9
—
—
—
0
0
173
1587
1.16
0.74
3.1
2.9
76.69
89.19
ug/l
0.69
166
1499
133
1198
1.16
0.72
3.7
2.9
—
—
—
0
0
5
26
1.93
0.71
1.2
1.5
92.40
69.81
umol/l
—
5
26
24
178
1.37
0.70
3.6
5.5
0.88
0.93
mmol/l
0.04
16
124
9
58
1.56
0.70
2.3
1.9
—
—
—
0
0
25
187
1.36
0.70
21.8
11.5
25.24
24.86
mmol/l
0.24
25
187
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
17
120
1.44
0.65
1.7
1.4
107.17
186.77
u/ml
1.96
12
67
10
62
1.63
0.65
1.1
1.1
59.60
141.33
iu/ml
—
5
15
84
736
1.18
0.64
1.5
1.5
—
—
—
0
0
5
29
1.73
0.64
1.2
2.3
—
—
—
0
0
107
957
1.16
0.64
13.6
7.3
1.16
1.11
inr
0.27
31
335
6
105
0.56
0.62
1.3
2.0
—
—
—
0
0
8
49
1.65
0.62
2.0
1.4
—
—
—
0
0
117
1057
1.15
0.61
5.5
5.1
36.42
37.34
g/l
1.16
112
1004
80
702
1.17
0.60
2.4
2.0
—
—
—
0
0
0
20
0.00
0.60
0.0
1.0
—
103.73
—
0
11
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
21
0.00
0.60
0.0
1.0
—
129.10
—
0
21
0
21
0.00
0.60
0.0
1.0
—
94.33
—
0
12
8
55
1.46
0.56
10.6
4.1
59.63
58.04
%
—
8
55
197
1850
1.13
0.56
9.2
8.9
4.16
3.91
e9/l
0.73
169
1612
78
688
1.17
0.56
3.9
3.1
1.02
1.02
kg/l
0.80
12
93
90
804
1.15
0.55
3.6
3.2
0.00
0.01
estimate
0.80
36
316
17
125
1.38
0.54
1.6
1.4
—
—
—
0
0
17
226
0.74
0.53
3.6
3.6
4.39
4.78
pmol/l
1.20
17
202
11
75
1.48
0.51
8.5
2.4
0.54
0.83
nmol/l
1.13
11
64
37
439
0.83
0.48
1.4
1.5
—
—
—
0
0
134
1243
1.12
0.46
2.9
2.5
70.03
72.13
nmol/l
0.40
128
1151
30
247
1.23
0.45
1.9
1.7
—
—
—
0
0
297
2879
1.12
0.44
3.4
3.3
5.77
5.64
mmol/l
0.75
285
2685
116
1071
1.12
0.43
1.7
1.7
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
24
293
0.81
0.42
1.5
1.4
—
—
—
0
0
25
204
1.24
0.41
1.3
1.3
271.52
261.14
miu/ml
0.06
14
105
0
15
0.00
0.41
0.0
2.7
—
—
—
0
0
0
15
0.00
0.41
0.0
2.6
—
118.40
—
0
15
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
2.1
—
—
—
0
0
0
16
0.00
0.41
0.0
3.2
—
—
—
0
0
0
16
0.00
0.41
0.0
3.2
—
—
—
0
0
8
59
1.36
0.41
2.9
4.9
358.00
378.96
umol/l
—
8
51
93
851
1.12
0.40
2.4
2.8
2.36
2.35
mmol/l
0.31
78
777
0
17
0.00
0.40
0.0
1.6
—
—
—
0
0
21
259
0.80
0.40
1.4
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.8
—
16.05
—
0
6
57
638
0.88
0.38
2.6
2.7
345.50
3449.56
umol/l
1.50
52
584
5
36
1.39
0.38
1.0
1.3
—
—
—
0
0
18
224
0.79
0.38
1.3
1.2
—
19.80
—
0
9
128
1198
1.10
0.37
9.8
7.9
1.21
1.22
mmol/l
0.72
117
1044
20
245
0.81
0.37
2.4
2.2
—
24.15
—
0
18
41
357
1.17
0.37
1.9
1.8
—
—
—
0
0
29
245
1.20
0.36
1.9
1.7
—
—
—
0
0
5
77
0.64
0.36
1.0
1.1
—
—
—
0
0
19
232
0.81
0.34
1.3
1.5
265.95
309.55
mu/l
0.57
19
206
90
832
1.11
0.33
2.8
2.7
23.08
28.93
ng/l
0.27
45
384
61
552
1.12
0.33
1.8
2.0
—
—
—
0
0
10
132
0.75
0.32
1.9
2.1
32.50
39.79
u/l
—
10
122
17
137
1.25
0.32
1.4
1.7
—
—
—
0
0
166
1582
1.08
0.32
7.0
6.0
57.42
55.43
%
1.38
154
1502
13
101
1.30
0.32
1.2
1.5
—
266.67
—
0
6
13
164
0.79
0.31
1.4
1.4
—
—
—
0
0
352
3465
1.13
0.31
9.6
8.3
25.61
27.79
u/l
1.29
344
3368
316
3095
1.10
0.30
3.8
3.7
2.89
2.87
mmol/l
0.14
305
2929
24
204
1.19
0.29
11.0
9.9
7.90
6.93
mmol/l
0.36
24
198
39
347
1.14
0.28
2.8
3.9
5.24
8.08
umol/l
1.15
33
293
26
300
0.86
0.28
1.7
2.3
5723.80
4064.26
u/l
—
7
130
28
243
1.16
0.27
1.3
1.3
—
—
—
0
0
151
1443
1.07
0.27
2.7
2.5
—
—
—
0
0
5
74
0.67
0.26
1.4
1.1
—
—
—
0
0
15
123
1.23
0.25
1.4
1.3
—
—
—
0
0
5
38
1.32
0.23
1.0
1.8
—
—
—
0
0
5
39
1.29
0.23
1.2
1.4
7486.20
22222.93
e6/l
—
5
29
165
1591
1.06
0.22
7.7
6.1
28.52
30.34
%
1.40
153
1514
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
3.6
—
49.33
—
0
12
0
12
0.00
0.21
0.0
1.2
—
199.08
—
0
12
5
43
1.16
0.21
1.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
24.26
—
0
13
81
764
1.08
0.20
1.5
1.6
1.32
1.37
mmol/l
0.20
73
671
39
356
1.11
0.20
3.4
3.0
17.57
22.63
%
1.14
14
111
12
99
1.22
0.20
2.4
1.5
—
—
—
0
0
15
175
0.85
0.19
4.7
2.1
52.49
45.17
u/ml
0.09
15
166
267
2620
1.06
0.18
4.6
4.2
38.58
37.88
mmol/mol
0.45
258
2493
5
70
0.71
0.17
1.0
1.5
17.82
16.34
u/l
—
5
60
20
225
0.88
0.16
2.5
1.6
—
—
—
0
0
143
1386
1.05
0.15
5.6
5.9
10.07
10.82
umol/l
0.39
135
1318
311
3071
1.06
0.15
3.5
3.5
4.73
4.73
mmol/l
0.04
300
2926
225
2206
1.05
0.15
7.7
6.5
77.73
78.28
u/l
0.07
215
2079
15
131
1.15
0.14
1.3
1.2
—
—
—
0
0
51
541
0.93
0.14
2.1
1.8
1.42
1.38
%
0.17
45
500
10
85
1.18
0.12
7.2
4.4
63.92
53.10
%
—
10
85
112
1087
1.04
0.11
4.0
3.1
113.36
32.42
u/l
0.45
107
1036
46
437
1.06
0.10
5.9
3.1
1560.81
597.39
ng/l
0.68
37
344
11
96
1.15
0.10
1.2
1.9
—
—
—
0
0
10
87
1.15
0.09
6.7
5.3
25.48
24.87
mmol/l
—
10
87
83
856
0.96
0.09
4.9
2.5
60.83
56.55
u/l
0.38
77
808
22
237
0.92
0.09
1.5
1.4
—
—
—
0
0
22
237
0.92
0.09
1.5
1.4
—
—
—
0
0
5
61
0.82
0.08
1.2
1.3
—
—
—
0
0
22
236
0.93
0.08
1.5
1.4
—
—
—
0
0
22
236
0.93
0.08
1.5
1.4
—
—
—
0
0
297
2945
1.03
0.08
4.0
3.8
—
—
—
0
0
7
67
1.05
0.08
1.1
1.7
—
—
—
0
0
235
2376
0.97
0.07
3.3
3.1
34.82
36.16
u/l
0.14
225
2290
7
85
0.82
0.07
1.6
1.9
—
—
—
0
0
69
710
0.97
0.07
2.8
2.1
223.95
268.35
u/l
0.15
63
683
8
93
0.86
0.07
1.6
2.0
—
—
—
0
0
308
3061
1.03
0.06
3.4
3.4
1.44
1.46
mmol/l
0.27
298
2908
226
2281
0.98
0.05
4.2
3.7
9.88
8.53
mm/h
0.83
218
2135
22
209
1.06
0.04
1.5
1.5
—
—
—
0
0
15
140
1.07
0.04
1.3
1.5
—
—
—
0
0
16
170
0.94
0.04
2.7
4.3
228.43
32.30
ug/l
—
8
131
10
109
0.92
0.04
1.2
1.3
—
—
—
0
0
43
441
0.97
0.03
1.7
1.9
—
—
—
0
0
330
3312
0.98
0.03
12.3
10.2
20.55
20.08
mg/l
0.09
246
2480
19
199
0.95
0.03
2.7
2.0
—
—
—
0
0
68
669
1.02
0.03
1.8
2.2
0.89
0.96
mg/l
0.15
56
488
26
252
1.03
0.02
1.0
1.0
—
—
—
0
0
11
117
0.94
0.01
14.1
9.8
1.39
1.20
mg/l
0.58
11
111
95
957
0.99
0.01
1.3
1.4
0.87
1.36
u/ml
1.02
29
244
10
94
1.07
0.01
1.8
1.3
63.90
52.24
pmol/l
—
10
89
28
274
1.02
0.00
2.6
2.2
0.55
0.66
ug/l
0.56
17
131
14
142
0.99
0.00
1.4
1.4
—
—
—
0
0
13
127
1.02
0.00
3.8
2.7
0.28
0.09
e6/l
0.59
13
122
16
163
0.98
0.00
1.4
1.4
—
—
—
0
0
39
393
0.99
0.00
2.5
2.4
2.44
2.42
mmol/l
0.65
34
340
83
825
1.01
0.00
2.1
2.1
—
—
—
0
0
91
905
1.01
0.00
2.3
2.2
—
—
—
0
0
294
2935
1.01
0.00
3.1
3.1
1.26
1.24
mmol/l
0.14
283
2778
5
53
0.94
0.00
2.4
2.0
129.40
130.26
g/l
—
5
38
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
49
1.02
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
-0.00
1.2
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
68
0.88
-0.00
1.2
1.6
—
—
—
0
0
5
54
0.93
-0.00
1.2
3.3
60.80
5.78
u/ml
—
5
54
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
55
0.91
-0.00
1.4
1.5
5.40
7.49
mmol/l
—
5
49
6
66
0.91
-0.00
1.3
1.6
—
—
—
0
0
5
52
0.96
-0.00
1.8
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
5
49
1.02
-0.00
1.2
1.8
—
—
—
0
0
5
52
0.96
-0.00
5.0
4.1
3.82
3.76
mmol/l
—
5
52
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
52
0.96
-0.00
1.2
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CLEFT_AND_CARIES and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CLEFT_AND_CARIES | 1.835 [1.26, 2.67] | 0.002 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 1798 males with Q17_CLEFT_AND_CARIES died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CLEFT_AND_CARIES.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.411% |
| 5 | No data | 2.223% |
| 10 | No data | 5.802% |
| 15 | No data | 10.596% |
| 20 | No data | 17.778% |
Relationships between endpoints
↥Index endpoint: Q17_CLEFT_AND_CARIES – Caries in Clefts patients
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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