No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519870 |
1. Apply sex-specific ruleNone |
519870 |
2. Check conditions
|
628 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
416 |
4. Check minimum number of eventsNone |
416 |
5. Include endpointsNone |
416 |
6. Filter based on genotype QC (FinnGen only) |
401 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF10
Similar endpoints
↥List of similar endpoints to
Caries in Clefts patients
based on the number of shared cases.
Similar with more cases:
- Cleft lip, lip and palate or palate
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities, including avohilmo
- Dental caries, including avohilmo
- Diseases of pulp and periapical tissues and dental caries
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4252 | 2191 | 2056 |
| Only index persons | 3920 | 2029 | 1891 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 24.85 | 25.22 | 24.43 |
| Only index persons | 26.57 | 26.87 | 26.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 401 | 253 | 148 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.07 |
| Median age at first event (years) | 37.40 | 37.59 | 37.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 416
- Matched controls
- 4160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q35.1
ICD-10 Finland
Cleft hard palate
1010.7
148.9
137
*
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
+∞
118.5
108
*
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
583.3
96.6
92
*
4122
FHL
Tympanostomy (tympanic tube)
17.7
93.0
81
56
4364
FHL
Pharyngeal tongue plastic
+∞
64.3
60
*
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
9.6
64.1
84
107
74920
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis unilateralis
709.8
63.6
61
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
13.9
60.4
59
49
SBB10
NOMESCO Finland
Dental impressions
6.2
59.8
128
277
SAA04
NOMESCO Finland
Special examination of mouth
8.1
59.6
91
139
7490A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS COMPLETA]
+∞
58.8
55
*
4362
FHL
Nozzle reconstruction
628.9
57.0
55
*
EB1MA
NOMESCO Finland
Cephalometry with X-ray
9.1
54.5
73
95
7492A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS UNILATERALIS COMPLETA]
576.5
52.7
51
*
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
7.7
51.5
81
127
4361
FHL
Lip plastic or reconstruction due to cleft lip
+∞
51.1
48
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
16.2
51.0
45
31
EBB10
NOMESCO Finland
Insertion of dental implant
20.2
47.0
37
20
K02.1
ICD-10 Finland
Caries of dentine
10.2
46.1
387
2359
Q37.0
ICD-10 Finland
Cleft hard palate with bilateral cleft lip
+∞
45.7
43
*
EAB30
NOMESCO Finland
Correction of cleft lip
462.5
43.0
42
*
Q35.9
ICD-10 Finland
Cleft palate, unspecified
450.2
41.9
41
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
7.8
41.5
62
91
Q35.71
ICD-10 Finland
Submucous cleft palate
425.7
39.8
39
*
K00.00
ICD-10 Finland
Hypodontia
13.0
37.3
37
31
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
6.6
35.2
62
108
7490C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS SUBMUCOSAE]
+∞
32.7
31
*
ECB17
NOMESCO Finland
Operation of gingival cleft
+∞
32.7
31
*
4368
FHL
Closing the fistula of the mouth
+∞
32.7
31
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
5.1
32.6
77
176
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.6
32.2
56
96
7490B
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS INCOMPLETA]
+∞
31.7
30
*
EEC05
NOMESCO Finland
Le Fort I osteotomy
86.6
29.2
32
*
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
7.3
29.1
45
68
4451
FHL
Guitar cutting
5.7
28.7
58
115
74929
ICD-8 Finland
Cleft palate and cleft lip, Unspecified
+∞
28.5
27
*
4365
FHL
Correction of nasal deformity
+∞
28.5
27
*
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
5.9
28.1
54
102
Q36.9
ICD-10 Finland
Cleft lip, unilateral
300.7
28.1
28
*
74924
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis bilateralis
+∞
27.4
26
*
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
8.7
27.3
36
45
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
6.8
27.2
45
73
4367
FHL
Bone transfer to the upper jaw
265.3
24.9
25
*
ZSZ10
NOMESCO Finland
Secondary repair operation
138.3
24.9
26
*
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
6.0
24.4
46
85
7492C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS BILATERALIS COMPLETA]
+∞
24.2
23
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.8
23.8
246
1404
UDC00
NOMESCO Finland
Ear microscopy
4.8
23.4
58
137
EHC40
NOMESCO Finland
Repair of submucous cleft palate
231.7
21.8
22
*
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
7.5
21.5
32
46
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
19.1
21.2
32
18
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.5
21.2
85
284
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
9.2
20.9
26
30
SAA03
NOMESCO Finland
Extended examination of mouth
2.7
20.7
249
1497
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
5.0
20.4
46
100
ZXD10
NOMESCO Finland
Scheduled procedure
2.6
20.2
180
934
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
30.7
19.9
26
9
EHC10
NOMESCO Finland
Plastic repair of oronasal or oroantral fistula of palate
209.6
19.7
20
*
WZC00
NOMESCO Finland
Treatment plan or consultation
2.5
19.0
202
1131
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
19.9
18.9
28
15
EBB15
NOMESCO Finland
Insertion of dental implant abutment
31.7
18.5
24
8
74910
ICD-8 Finland
Cleft palate and cleft lip, Cheiloschisis unilateralis
187.7
17.7
18
*
Q35.3
ICD-10 Finland
Cleft soft palate
187.7
17.7
18
*
SFA10
NOMESCO Finland
One-surface restoration
2.6
17.0
297
2049
1450
FHL
Otomicroscopy
18.9
16.7
25
14
DLW00
NOMESCO Finland
Correction of cleft nose
176.8
16.6
17
*
9808
FHL
Bone graft
176.8
16.6
17
*
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
4.5
16.2
41
98
WX110
NOMESCO Finland
Infiltration anesthesia
3.2
16.0
357
2731
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.9
16.0
90
364
Q37.99
ICD-10 Finland
Cleft palate with cleft lip NOS
+∞
15.7
15
*
Z2221
NOMESCO Finland
Medical doctor
2.4
15.6
149
779
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
6.1
15.1
27
47
SFA20
NOMESCO Finland
Two-surface restoration
2.5
15.0
305
2189
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
14.8
157
856
ZXB10
NOMESCO Finland
Medial
26.2
14.8
20
8
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
3.9
14.8
47
133
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
4.4
14.8
39
96
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
5.0
14.7
33
71
Q37.90
ICD-10 Finland
Unspecified cheft palate with cleft lip, unilateral
+∞
14.7
14
*
74912
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis unilateralis
+∞
14.7
14
*
H66.9
ICD-10 Finland
Otitis media, unspecified
2.9
14.4
75
290
SXC05
NOMESCO Finland
Other oral or dental procedure
3.1
14.0
67
246
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
5.1
13.8
30
63
ENC80
NOMESCO Finland
Plastic operation of soft palate for voice distubance
+∞
13.6
13
*
4366
FHL
Upper jaw scar repair surgery
+∞
13.6
13
*
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
26.8
13.5
18
7
EBA00
NOMESCO Finland
Extraction of tooth
2.2
13.5
203
1267
K07.14
ICD-10 Finland
Retrognaty, maxillary
22.0
13.4
19
9
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
41.5
13.2
16
*
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
13.8
12.6
21
16
SAA02
NOMESCO Finland
Basic examination of mouth
2.8
12.5
356
2838
SPC20
NOMESCO Finland
Implant borne crown
18.7
12.1
18
10
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.2
12.0
33
84
ZXA10
NOMESCO Finland
Bilateral
2.6
11.9
80
351
SAA01
NOMESCO Finland
Simple examination of mouth
2.7
11.9
359
2898
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
31.0
11.7
15
5
SJX20
NOMESCO Finland
Orthodontic treatment/control appointment
4.5
11.7
29
68
Z01.2
ICD-10 Finland
Dental examination
2.1
11.7
256
1807
4347
FHL
Osteotomy of the upper jaw
+∞
11.5
11
*
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
25.8
11.2
15
6
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
4.0
11.1
32
84
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
10.5
11.1
21
21
DLD20
NOMESCO Finland
Rhinoplasty
28.9
10.8
14
5
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
28.9
10.8
14
5
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
2.0
10.5
262
1904
4204
FHL
Molding of the cartilaginous part of the nose
112.8
10.5
11
*
Q35.70
ICD-10 Finland
Cleft uvula
+∞
10.5
10
*
DCD00
NOMESCO Finland
Myringoplasty
13.6
10.2
17
13
EBA15
NOMESCO Finland
Extraction of multiple teeth
5.2
10.2
21
42
R1260
NOMESCO Finland
Evaluation of communicative skills
11.7
10.1
18
16
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.0
10.0
46
165
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
13.8
9.7
16
12
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
8.1
9.7
21
27
DFF00
NOMESCO Finland
Pure tone audiometry
3.1
9.7
42
145
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
18.1
9.5
14
8
ZZG00
NOMESCO Finland
Graft of cartilage
102.3
9.5
10
*
SPF20
NOMESCO Finland
Temporary relining of dentures
30.8
9.4
12
*
ZSZ00
NOMESCO Finland
Primary repair operation
+∞
9.4
9
*
SDA03
NOMESCO Finland
Periodontal treatment
1.9
9.3
209
1444
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
9.3
112
626
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
37.6
9.1
11
*
SPF10
NOMESCO Finland
Demanding reparation of dental prosthesis
24.6
9.0
12
5
R4130
NOMESCO Finland
Speech therapy
4.7
8.9
21
47
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
8.8
54
226
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
11.9
8.6
15
13
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.0
8.6
115
665
ZXE00
NOMESCO Finland
One hour or less
1.9
8.5
170
1123
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
28.2
8.5
11
*
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
3.9
8.5
25
67
4203
FHL
Mobilization and repositioning of the external pyramid
91.8
8.4
9
*
Q35
ICD-10 Finland
Cleft palate
91.8
8.4
9
*
7491A
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOSCHISIS UNILATERALIS COMPLETA]
+∞
8.4
8
*
Q36.0
ICD-10 Finland
Cleft lip, bilateral
+∞
8.4
8
*
EB1WA, ,
NOMESCO Finland
11.1
8.4
15
14
SJC40
NOMESCO Finland
Removal of fixed orthodontic appliance with at most 6 brackets
3.3
8.3
32
103
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
14.9
8.3
13
9
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
14.9
8.3
13
9
H74.1
ICD-10 Finland
Adhesive middle ear disease
34.1
8.1
10
*
J01DA08
ATC
[U] cefaclor
2.2
8.1
81
420
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
3.2
7.9
32
106
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.8
7.8
281
2203
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
6.1
7.8
20
34
SPB10
NOMESCO Finland
Manufacture of a temporary crown to tooth at the dental office
15.4
7.8
12
8
DLD00
NOMESCO Finland
Reconstruction of cartilage of nose
45.9
7.7
9
*
SPB20
NOMESCO Finland
Temporary bridge
18.8
7.6
11
6
SFA30
NOMESCO Finland
Three-surface restoration
1.8
7.6
177
1215
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
25.5
7.6
10
*
4741B
ICD-9 Finland
Chronic disease of tonsils and adenoids, Hypertrophy of tonsils and adenoids[HYPERTROPHIA TONSILLAE PHARYNGICAE]
4.4
7.6
19
45
H04
ICPC
Ear discharge
4.5
7.5
18
41
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
3.6
7.4
24
69
Q37.3
ICD-10 Finland
Cleft soft palate with unilateral cleft lip
+∞
7.3
7
*
7491F
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOGNATOSCHISIS UNILATERALIS INCOMPLETA]
+∞
7.3
7
*
7491B
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOSCHISIS UNILATERALIS INCOMPLETA]
+∞
7.3
7
*
EBA10
NOMESCO Finland
Operative extraction of tooth
1.9
7.0
101
595
WX290
NOMESCO Finland
Other blockage of nerve
1.7
6.9
255
1978
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
40.7
6.8
8
*
SDA02
NOMESCO Finland
Periodontal treatment, brief
1.7
6.7
177
1248
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
8.9
6.6
13
15
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
10.3
6.6
12
12
H65.2
ICD-10 Finland
Chronic serous otitis media
5.9
6.5
17
30
4141
FHL
Myringoplasty (also for reasons other than inflammation)
70.9
6.4
7
*
R49.2
ICD-10 Finland
Hypernasality and hyponasality
70.9
6.4
7
*
DLD10
NOMESCO Finland
Reconstruction of cartilage and bone of nose
70.9
6.4
7
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
4.2
6.4
17
42
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
3.1
6.3
26
87
SPA10
NOMESCO Finland
Setting attachments on tooth or implanted bracket or imblant based structures
+∞
6.3
6
*
Q35.7
ICD-10 Finland
Cleft uvula
+∞
6.3
6
*
K01.0
ICD-10 Finland
Embedded teeth
3.6
6.2
20
57
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.0
6.2
27
94
H66
ICD-10 Finland
Suppurative and unspecified otitis media
3.2
6.0
24
79
LabWAS
↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
14
42
3.41
4.08
1.4
1.3
—
—
—
0
0
55
337
1.73
3.28
10.7
9.6
104.55
104.52
mmol/l
0.02
55
337
5
8
6.31
2.38
9.0
5.1
—
—
—
0
0
27
148
1.88
2.35
18.9
13.6
1.36
1.41
%
0.11
27
148
16
72
2.27
2.30
6.5
5.5
—
3893.14
—
0
7
27
151
1.84
2.22
18.9
13.5
95.97
94.18
%
2.19
27
151
26
144
1.86
2.20
19.3
14.0
0.74
0.69
%
0.23
26
144
63
443
1.50
2.17
3.0
2.6
2.38
2.40
g/l
0.11
57
413
46
676
0.64
2.16
1.3
1.3
10.93
8.48
u/ml
0.09
24
269
366
3442
1.53
2.10
15.0
12.1
139.65
139.63
mmol/l
0.05
358
3366
37
232
1.65
2.07
19.9
11.4
1.12
1.31
mmol/l
0.93
37
227
16
76
2.15
2.05
1.6
2.4
1.83
2.31
index
—
6
42
14
63
2.26
2.03
1.1
1.3
—
—
—
0
0
34
212
1.66
1.95
11.6
7.3
24.10
24.02
mmol/l
0.05
34
212
364
3445
1.45
1.75
15.3
12.2
3.93
3.92
mmol/l
0.21
355
3361
213
1873
1.28
1.74
4.0
3.2
0.00
0.00
estimate
-0.00
42
381
10
43
2.36
1.60
1.2
1.4
—
—
—
0
0
23
137
1.72
1.59
11.5
6.1
0.55
0.58
%
0.23
23
137
213
1889
1.26
1.57
4.1
3.3
0.00
0.01
estimate
0.50
40
364
108
884
1.30
1.51
3.5
2.9
0.36
0.28
e6/l
0.18
82
612
104
850
1.30
1.47
2.4
2.5
2.76
2.51
mg/l
0.42
92
744
209
1862
1.25
1.44
7.0
5.3
6.36
6.35
mmol/l
0.03
186
1706
208
1855
1.24
1.41
4.0
3.2
0.00
0.00
estimate
0.50
40
387
56
732
0.73
1.41
1.3
1.3
22.19
23.09
iu/ml
0.04
19
209
35
242
1.49
1.35
2.3
2.7
—
—
—
0
0
5
112
0.44
1.14
1.2
1.2
—
—
—
0
0
5
112
0.44
1.14
1.2
1.2
—
—
—
0
0
68
547
1.29
1.09
3.6
2.6
1.25
0.76
e6/l
0.69
36
257
44
332
1.36
1.09
1.8
1.5
949.28
1231.22
nmol/l
1.45
34
269
37
271
1.40
1.09
6.3
5.7
—
—
—
0
0
5
21
2.40
1.09
1.0
1.2
629.00
846.63
u/l
—
5
16
64
514
1.29
1.05
3.7
2.7
3.65
2.92
e6/l
0.29
33
224
142
1254
1.20
0.99
6.0
5.3
37.01
37.51
g/l
0.60
137
1203
5
23
2.19
0.98
1.4
1.0
—
—
—
0
0
301
2844
1.21
0.98
4.5
4.4
14.33
14.43
pmol/l
0.34
287
2676
0
31
0.00
0.96
0.0
1.0
—
—
—
0
0
332
3171
1.23
0.95
4.1
3.8
5.75
5.66
mmol/l
0.50
317
2978
6
27
2.24
0.94
1.2
1.5
88.50
69.67
umol/l
—
6
27
116
1010
1.21
0.93
3.6
3.4
8.71
8.75
mmol/l
0.02
97
894
336
3217
1.23
0.91
17.5
14.6
13.27
13.24
%
0.21
331
3191
159
1431
1.18
0.88
3.9
2.9
0.00
0.02
estimate
1.15
37
331
90
769
1.22
0.88
4.1
4.3
6.69
9.64
mg/mmol
0.56
62
500
96
827
1.21
0.86
2.5
2.2
—
—
—
0
0
6
31
1.95
0.84
1.2
2.5
—
—
—
0
0
18
121
1.51
0.84
2.7
3.2
67.69
125.47
ng/l
0.76
13
111
31
232
1.36
0.84
20.9
12.7
24.90
24.80
mmol/l
0.06
31
232
27
199
1.38
0.80
1.7
1.7
—
—
—
0
0
6
33
1.83
0.79
2.0
1.6
0.57
0.48
e9/l
—
6
33
12
74
1.64
0.79
1.1
1.1
59.60
141.33
iu/ml
—
5
15
97
845
1.19
0.78
4.0
3.1
1.02
1.02
kg/l
1.04
59
543
343
3306
1.21
0.77
5.4
5.2
1.81
1.75
mu/l
0.44
333
3160
13
197
0.65
0.77
1.3
1.8
2.23
3.25
mg/l
—
7
136
406
3999
1.63
0.77
21.2
18.0
267.90
259.69
e9/l
1.87
396
3939
91
790
1.19
0.76
1.6
1.6
—
—
—
0
0
12
184
0.64
0.75
1.1
1.1
12.92
4.02
u/ml
—
7
108
138
1242
1.17
0.75
11.8
7.9
1.21
1.22
mmol/l
0.91
133
1170
5
24
2.10
0.74
1.0
1.1
—
—
—
0
0
5
25
2.01
0.73
1.0
1.1
—
—
—
0
0
134
1207
1.16
0.72
2.1
1.9
97.65
97.13
pmol/l
0.05
73
639
406
4003
1.59
0.70
21.1
18.0
4.63
4.60
e12/l
0.60
396
3938
43
351
1.25
0.66
3.8
2.4
35.53
30.21
u/l
0.78
36
286
15
103
1.47
0.66
1.2
1.3
—
—
—
0
0
210
1965
1.14
0.65
3.5
3.3
79.79
86.46
ug/l
0.34
201
1883
18
129
1.41
0.64
2.3
1.6
—
—
—
0
0
5
29
1.73
0.64
1.0
1.1
2002.00
1643.62
miu/ml
—
5
29
19
138
1.39
0.63
1.3
1.4
—
—
—
0
0
52
436
1.22
0.63
3.3
3.2
18.52
22.71
%
0.84
17
143
166
1532
1.14
0.63
3.2
2.8
70.34
71.68
nmol/l
0.28
159
1441
62
530
1.20
0.62
3.6
3.2
107.33
535.04
ng/l
1.09
36
313
0
21
0.00
0.60
0.0
1.8
—
17.16
—
0
14
0
22
0.00
0.59
0.0
1.6
—
—
—
0
0
22
286
0.76
0.59
1.6
1.5
65.65
61.38
ug/l
0.17
14
243
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
96.31
—
0
13
0
23
0.00
0.58
0.0
1.1
—
40.85
—
0
23
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
23
0.00
0.58
0.0
1.0
—
124.65
—
0
23
0
23
0.00
0.58
0.0
1.0
—
105.92
—
0
13
8
54
1.49
0.57
2.3
1.5
—
—
—
0
0
219
2071
1.12
0.54
9.9
9.7
4.16
3.90
e9/l
0.82
191
1803
382
3748
1.24
0.53
11.3
9.8
26.23
27.72
u/l
0.81
375
3678
59
511
1.18
0.53
1.8
1.5
469.06
29060253.96
pmol/l
0.80
51
468
18
136
1.34
0.50
1.6
1.4
0.00
0.01
iu/ml
—
6
21
151
1406
1.12
0.48
10.9
8.2
1.21
1.22
mmol/l
0.46
139
1242
5
84
0.59
0.46
1.2
1.5
—
—
—
0
0
36
303
1.21
0.45
1.9
1.8
—
—
—
0
0
7
51
1.38
0.44
1.0
1.7
—
—
—
0
0
42
487
0.85
0.43
1.5
1.6
1108.36
947.04
mu/l
0.31
32
416
5
31
1.62
0.43
1.0
2.3
—
1.26
—
0
10
106
974
1.12
0.43
4.0
3.3
0.00
0.01
estimate
0.80
42
374
12
87
1.39
0.42
11.4
2.4
0.68
0.89
nmol/l
0.72
12
76
18
140
1.30
0.42
1.8
1.4
107.17
195.77
u/ml
2.35
12
77
6
94
0.63
0.42
1.2
1.6
—
—
—
0
0
8
58
1.39
0.41
1.3
2.8
42.47
22.42
mg/l
—
8
52
8
58
1.39
0.41
1.3
2.8
71.94
32.13
mg/l
—
8
53
71
638
1.14
0.41
2.0
2.2
—
—
—
0
0
0
17
0.00
0.40
0.0
2.9
—
—
—
0
0
0
17
0.00
0.40
0.0
2.8
—
119.29
—
0
17
5
34
1.48
0.40
1.0
1.2
—
—
—
0
0
12
88
1.37
0.40
1.7
1.4
407.33
268.46
ug/g
—
6
42
258
2486
1.10
0.40
8.5
7.3
78.89
78.68
u/l
0.03
247
2363
24
196
1.24
0.40
3.7
5.3
0.87
0.72
mmol/l
0.10
16
140
0
19
0.00
0.39
0.0
3.1
—
—
—
0
0
0
19
0.00
0.39
0.0
3.1
—
—
—
0
0
27
322
0.83
0.38
1.5
1.4
—
—
—
0
0
171
1621
1.09
0.37
3.0
2.7
—
—
estimate
—
0
0
313
3050
1.11
0.37
5.4
4.8
38.12
37.41
mmol/mol
0.60
304
2922
6
41
1.47
0.36
1.0
1.4
—
—
—
0
0
349
3423
1.12
0.35
4.7
4.4
2.89
2.82
mmol/l
0.67
341
3272
13
100
1.31
0.34
1.2
2.0
—
—
—
0
0
136
1440
0.92
0.33
2.0
1.8
1.33
1.37
mmol/l
0.22
125
1275
36
313
1.16
0.33
1.8
1.7
—
—
—
0
0
106
988
1.10
0.33
5.0
2.7
59.17
60.45
u/l
0.08
99
935
16
198
0.80
0.33
1.6
1.8
—
—
—
0
0
92
854
1.10
0.31
2.9
2.1
160.79
244.39
u/l
0.49
87
825
46
410
1.14
0.31
3.3
3.9
4.92
7.48
umol/l
1.32
39
354
7
99
0.70
0.31
1.1
1.1
—
11.92
—
0
28
39
344
1.15
0.31
2.6
2.4
0.66
0.68
ug/l
0.05
20
164
28
241
1.17
0.30
1.3
1.3
318.29
256.56
miu/ml
0.36
15
124
22
259
0.84
0.29
1.6
1.4
—
—
—
0
0
347
3412
1.10
0.28
4.2
4.1
4.75
4.71
mmol/l
0.42
337
3278
25
214
1.18
0.28
1.2
1.1
1.51
1.52
g/l
0.14
25
214
13
103
1.27
0.28
2.3
1.5
—
—
—
0
0
61
558
1.11
0.28
5.8
3.3
1230.06
594.10
ng/l
0.58
50
439
331
3249
1.09
0.28
12.4
10.1
94.44
94.85
ml/min/173m2
0.13
296
2912
8
64
1.25
0.27
2.5
2.1
0.00
0.00
g/l
—
8
59
25
215
1.17
0.27
1.2
1.1
0.93
0.90
g/l
0.32
25
215
15
122
1.24
0.27
2.1
1.5
163.57
137.04
au/ml
—
7
40
5
73
0.68
0.26
1.0
1.2
—
—
—
0
0
32
283
1.14
0.25
1.0
1.0
—
—
—
0
0
47
427
1.11
0.25
1.9
1.9
—
—
—
0
0
54
588
0.91
0.25
1.9
1.8
3.65
3.46
ratio
0.42
37
448
23
265
0.86
0.24
1.6
1.5
1.25
1.18
ratio
—
10
167
23
265
0.86
0.24
1.6
1.5
0.92
0.94
ratio
—
10
167
23
265
0.86
0.24
1.6
1.5
0.91
1.20
ratio
—
10
167
6
81
0.74
0.24
1.0
1.5
15.68
15.76
u/l
—
6
68
6
81
0.74
0.24
1.3
1.1
—
—
—
0
0
325
3194
1.08
0.24
3.5
3.5
1.28
1.23
mmol/l
0.52
315
3039
27
237
1.15
0.24
1.3
1.5
—
—
—
0
0
108
1024
1.07
0.23
2.7
2.9
2.36
2.36
mmol/l
0.24
97
958
5
38
1.32
0.23
1.0
1.4
—
—
—
0
0
5
38
1.32
0.23
1.0
1.3
—
—
—
0
0
170
1638
1.06
0.23
5.9
6.2
9.80
10.81
umol/l
0.72
161
1559
5
39
1.29
0.23
1.0
1.4
—
—
—
0
0
5
39
1.29
0.23
1.0
1.4
—
—
—
0
0
11
135
0.81
0.22
1.3
2.3
3.06
4.05
iu/l
—
5
55
5
41
1.22
0.22
1.0
1.4
—
—
—
0
0
5
41
1.22
0.22
1.0
1.4
—
—
—
0
0
29
258
1.13
0.22
1.3
1.3
—
—
—
0
0
33
366
0.89
0.21
1.2
1.3
155.25
167.23
u/ml
0.04
12
148
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
17
198
0.85
0.21
1.5
1.4
—
—
—
0
0
5
43
1.16
0.21
2.8
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
6
50
1.20
0.20
1.0
1.1
—
—
—
0
0
6
51
1.18
0.19
2.2
3.1
5.98
6.72
pmol/l
—
6
51
103
985
1.06
0.18
2.8
2.8
21.38
26.38
ng/l
0.28
53
473
344
3399
1.07
0.18
4.1
4.1
1.44
1.45
mmol/l
0.12
335
3253
20
176
1.14
0.17
1.6
1.7
—
—
—
0
0
25
224
1.12
0.17
1.7
1.6
—
—
—
0
0
5
68
0.73
0.17
1.2
1.9
—
—
—
0
0
43
462
0.92
0.16
1.5
1.6
3.57
3.43
mmol/l
0.27
24
323
116
1117
1.05
0.16
3.2
2.5
0.00
0.01
estimate
0.74
37
323
6
77
0.78
0.15
1.3
1.6
—
—
—
0
0
79
753
1.06
0.15
2.0
1.5
17.97
20.54
nmol/l
1.08
70
676
362
3587
1.07
0.15
13.9
11.8
20.49
20.45
mg/l
0.01
295
2818
118
1140
1.05
0.14
1.3
1.5
0.81
1.87
u/ml
1.63
33
303
32
345
0.92
0.13
1.8
2.3
4464.16
5322.34
u/l
—
10
148
10
117
0.85
0.13
1.2
1.4
—
—
—
0
0
25
271
0.92
0.11
1.4
1.6
297.01
305.56
mu/l
0.08
25
244
125
1217
1.04
0.11
1.9
1.8
—
—
—
0
0
273
2700
1.03
0.09
3.7
3.4
36.74
36.71
u/l
0.00
263
2620
130
1271
1.03
0.09
4.2
3.3
103.01
30.94
u/l
0.48
125
1212
17
155
1.10
0.09
1.3
1.4
—
—
—
0
0
6
58
1.03
0.08
1.0
1.1
—
—
—
0
0
56
539
1.05
0.08
1.8
2.1
—
—
—
0
0
5
61
0.82
0.08
1.0
1.1
—
17.62
—
0
27
5
63
0.79
0.08
2.6
2.0
127.60
130.53
g/l
—
5
51
16
174
0.92
0.07
1.4
1.5
49.65
53.11
ug/l
0.11
16
174
6
72
0.83
0.07
1.2
1.5
—
—
—
0
0
6
73
0.82
0.07
2.0
2.6
—
—
—
0
0
22
235
0.93
0.07
1.5
1.7
0.42
0.28
mg/l
0.51
11
102
8
92
0.87
0.07
1.5
1.9
—
—
—
0
0
9
100
0.90
0.06
1.6
2.1
—
—
—
0
0
16
148
1.08
0.06
1.3
1.2
—
4.57
—
0
20
20
212
0.94
0.05
2.7
1.9
—
—
—
0
0
17
159
1.07
0.05
1.4
1.3
—
—
—
0
0
24
252
0.95
0.05
1.2
1.3
—
17.35
—
0
13
11
103
1.07
0.02
1.7
1.3
60.82
90.64
pmol/l
0.35
11
97
20
193
1.04
0.01
5.8
2.1
100.66
44.97
u/ml
0.51
20
183
60
608
0.98
0.01
2.0
1.8
1.41
1.37
%
0.17
53
557
101
1018
0.99
0.01
2.3
2.3
—
—
—
0
0
20
194
1.03
0.00
2.4
4.5
166.81
29.06
ug/l
0.37
11
148
255
2548
1.00
0.00
4.5
4.0
10.16
8.44
mm/h
1.44
248
2416
13
127
1.02
0.00
1.5
1.9
268.62
222.79
pmol/l
0.76
13
121
16
163
0.98
0.00
1.4
1.5
—
—
—
0
0
79
787
1.00
0.00
1.9
2.1
0.84
1.04
mg/l
0.47
64
582
94
936
1.01
0.00
2.1
2.2
—
—
—
0
0
5
57
0.88
0.00
1.4
1.5
5.40
7.54
mmol/l
—
5
50
5
54
0.93
0.00
1.4
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
8
85
0.94
-0.00
1.1
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
59
1.02
-0.00
1.2
3.3
52.33
5.57
u/ml
—
6
59
0
6
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
55
0.91
-0.00
1.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.0
—
4.58
—
0
8
0
8
0.00
-0.00
0.0
3.0
—
11.43
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.1
—
266.67
—
0
6
307
3070
1.00
-0.00
4.0
3.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.4
—
3.92
—
0
5
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CLEFT_AND_CARIES and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CLEFT_AND_CARIES | 1.835 [1.26, 2.67] | 0.002 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 1798 males with Q17_CLEFT_AND_CARIES died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CLEFT_AND_CARIES.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.411% |
| 5 | No data | 2.223% |
| 10 | No data | 5.802% |
| 15 | No data | 10.596% |
| 20 | No data | 17.778% |
Relationships between endpoints
↥Index endpoint: Q17_CLEFT_AND_CARIES – Caries in Clefts patients
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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