cleft lip: ['Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
519447 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
625 |
4. Check minimum number of eventsNone |
625 |
5. Include endpointsNone |
625 |
6. Filter based on genotype QC (FinnGen only) |
625 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Cleft lip, lip and palate or palate
based on the number of shared cases.
Similar with more cases:
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8348 | 4172 | 4162 |
| Only index persons | 6932 | 3502 | 3430 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.12 | 0.12 |
| Only index persons | 0.13 | 0.13 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 1.21 | 1.31 | 1.00 |
| Only index persons | 1.51 | 1.76 | 1.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 625 | 388 | 237 |
| Unadjusted period prevalence (%) | 0.12 | 0.13 | 0.10 |
| Median age at first event (years) | 2.80 | 2.67 | 3.02 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 574
- Matched controls
- 5748
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q35.1
ICD-10 Finland
Cleft hard palate
+∞
184.6
167
*
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
+∞
176.4
160
*
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
+∞
138.2
127
*
74920
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis unilateralis
+∞
94.4
88
*
4364
FHL
Pharyngeal tongue plastic
951.8
85.9
82
*
7490A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS COMPLETA]
+∞
81.2
76
*
4362
FHL
Nozzle reconstruction
+∞
70.3
66
*
7492A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS UNILATERALIS COMPLETA]
+∞
64.8
61
*
4361
FHL
Lip plastic or reconstruction due to cleft lip
+∞
62.7
59
*
4122
FHL
Tympanostomy (tympanic tube)
14.5
59.0
103
85
Q37.0
ICD-10 Finland
Cleft hard palate with bilateral cleft lip
+∞
57.2
54
*
EAB30
NOMESCO Finland
Correction of cleft lip
+∞
55.1
52
*
Q35.9
ICD-10 Finland
Cleft palate, unspecified
+∞
52.9
50
*
Q35.71
ICD-10 Finland
Submucous cleft palate
+∞
49.7
47
*
74929
ICD-8 Finland
Cleft palate and cleft lip, Unspecified
+∞
48.6
46
*
SBB10
NOMESCO Finland
Teeth copy
6.1
48.0
145
299
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
9.2
44.7
98
125
7490C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS SUBMUCOSAE]
+∞
42.2
40
*
7490B
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS INCOMPLETA]
+∞
41.1
39
*
4368
FHL
Closing the fistula of the mouth
+∞
40.1
38
*
74924
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis bilateralis
+∞
40.1
38
*
Q36.9
ICD-10 Finland
Cleft lip, unilateral
+∞
40.1
38
*
SJX10
NOMESCO Finland
Short check-up visit for orthodontisk therapy
7.4
39.7
100
158
4367
FHL
Bone transfer to the upper jaw
+∞
37.9
36
*
ECB17
NOMESCO Finland
Operation for cleft gingiva
+∞
36.9
35
*
SAA04
NOMESCO Finland
Special inverstigation of mouth
6.3
36.9
105
196
EB1MA
NOMESCO Finland
Cephalometry with X-ray
9.0
36.8
81
103
7492C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS BILATERALIS COMPLETA]
+∞
34.7
33
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
10.1
34.7
71
79
EEC05
NOMESCO Finland
Le Fort I osteotomy
56.3
31.7
37
7
4365
FHL
Correction of nasal deformity
+∞
31.5
30
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
7.5
30.7
75
112
74910
ICD-8 Finland
Cleft palate and cleft lip, Cheiloschisis unilateralis
+∞
30.5
29
*
EBB10
NOMESCO Finland
Insertion of dental implant
18.7
29.3
45
26
ZSZ10
NOMESCO Finland
Secondary repair operation
306.6
29.0
29
*
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
109.0
28.9
31
*
K00.00
ICD-10 Finland
Hypodontia
16.7
28.1
45
29
H65.3
ICD-10 Finland
Chronic mucoid otitis media
7.7
26.8
64
92
Q35.3
ICD-10 Finland
Cleft soft palate
+∞
26.2
25
*
EHC10
NOMESCO Finland
Plastic repair of oronasal or oroantral fistula of palate
+∞
26.2
25
*
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
20.7
25.1
37
19
DLW00
NOMESCO Finland
Correction of cleft nose
+∞
24.1
23
*
SJD00
NOMESCO Finland
Removal or reattacment of arrow in fixed orthodontisk device
6.6
23.8
63
105
1450
FHL
Otomicroscopy
20.6
23.7
35
18
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
11.5
23.5
44
41
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
5.1
23.4
77
168
EHC40
NOMESCO Finland
Correction of submucous cleft palate
239.0
22.8
23
*
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
13.4
22.4
39
31
EBB15
NOMESCO Finland
Insertion of dental implant abutment
26.3
22.0
30
12
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
5.6
21.7
66
131
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
8.8
21.3
46
56
4451
FHL
Guitar cutting
4.7
21.1
76
182
SJC50
NOMESCO Finland
Removal of orthodontisk device with at least 7 brackets
6.3
21.0
57
98
4366
FHL
Upper jaw scar repair surgery
+∞
21.0
20
*
74912
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis unilateralis
+∞
19.9
19
*
SJD20
NOMESCO Finland
Attachment of modifiable arrow of fixed orthodontisk device
7.0
19.7
49
75
SJB00
NOMESCO Finland
Fitting of loose orthodontic device with user information
6.2
19.3
53
93
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
12.5
18.0
32
27
ENC80
NOMESCO Finland
Plastic operation of soft palate for voice distubance
+∞
17.8
17
*
Q37.99
ICD-10 Finland
Cleft palate with cleft lip NOS
+∞
17.8
17
*
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
7.0
17.7
44
67
K07.14
ICD-10 Finland
Retrognaty, maxillary
22.7
17.0
24
11
UDC00
NOMESCO Finland
Ear microscopy
3.9
16.4
70
197
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
21.7
16.1
23
11
DLD20
NOMESCO Finland
Rhinoplasty
34.4
15.8
20
6
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
87.5
15.6
17
*
4347
FHL
Osteotomy of the upper jaw
87.5
15.6
17
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.1
14.7
88
321
ZXB10
NOMESCO Finland
Medial
19.7
14.3
21
11
SJD40
NOMESCO Finland
Fixation of ready made palatinal or lingual arrow
4.8
14.3
48
107
SJD30
NOMESCO Finland
Demanding attachment of arrow to fixed orthodontisk device
6.4
14.2
37
61
9808
FHL
Bone graft
77.0
13.6
15
*
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
11.3
13.6
25
23
R1260
NOMESCO Finland
Evaluation of communicative skills
16.7
13.5
21
13
SJA01
NOMESCO Finland
Estimation of need for orthodontic care
41.1
13.2
16
*
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
7.7
13.1
30
41
SJD10
NOMESCO Finland
Attachment of arrow to fixed orthodontisk device
4.7
13.0
44
99
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.0
12.8
211
1281
SPC20
NOMESCO Finland
Attachment of crone of tooth to implant
15.9
12.7
20
13
4204
FHL
Molding of the cartilaginous part of the nose
71.5
12.6
14
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.7
12.6
90
364
7491B
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOSCHISIS UNILATERALIS INCOMPLETA]
+∞
12.5
12
*
SAA03
NOMESCO Finland
Extended examination of mouth
1.9
12.3
278
1894
ZZG00
NOMESCO Finland
Graft of cartilage
38.4
12.3
15
*
SJB60
NOMESCO Finland
External device grinding and adaptation
5.3
12.2
37
74
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
5.1
12.1
38
79
SJA04
NOMESCO Finland
Very demanding plan for orthodontic care
21.8
12.1
17
8
SXC05
NOMESCO Finland
Other oral or dental procedure
3.2
12.1
67
230
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
15.1
11.9
19
13
4203
FHL
Mobilization and repositioning of the external pyramid
+∞
11.5
11
*
ZSZ00
NOMESCO Finland
Primary repair operation
122.3
11.5
12
*
SPA20
NOMESCO Finland
Selection and insertion of implantdistans
35.8
11.3
14
*
H66.9
ICD-10 Finland
Otitis media, unspecified
2.8
11.1
75
293
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
11.0
253
1715
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
3.5
10.9
51
155
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
10.9
10.8
20
19
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
18.2
10.8
16
9
7491A
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOSCHISIS UNILATERALIS COMPLETA]
+∞
10.4
10
*
Q35.70
ICD-10 Finland
Cleft uvula
+∞
10.4
10
*
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
26.5
9.8
13
5
SPB20
NOMESCO Finland
Temporary bridge between two or more teeth
20.4
9.8
14
7
SXC03
NOMESCO Finland
Other oral or dental procedure
13.7
9.7
16
12
ZZH22
NOMESCO Finland
Graft of patients own bone, block
55.9
9.7
11
*
SPA10
NOMESCO Finland
Setting attachments on tooth or implanted bracket or imblant based structures
55.9
9.7
11
*
SPF10
NOMESCO Finland
Demanding repatation of teeth prosthesis
11.6
9.6
17
15
78159
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Laesio loquendi alia sive NUD
30.6
9.4
12
*
Q35
ICD-10 Finland
Cleft palate
+∞
9.4
9
*
Q37.90
ICD-10 Finland
Unspecified cheft palate with cleft lip, unilateral
+∞
9.4
9
*
EHC30
NOMESCO Finland
Reconstruction of palate
+∞
9.4
9
*
Q37.3
ICD-10 Finland
Cleft soft palate with unilateral cleft lip
+∞
9.4
9
*
4141
FHL
Myringoplasty (also for reasons other than inflammation)
22.1
9.4
13
6
R4130
NOMESCO Finland
Speech therapy
6.1
9.1
24
41
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
9.1
154
927
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
19.0
9.0
13
7
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
19.0
9.0
13
7
EB1WA
NOMESCO Finland
NA
12.8
8.9
15
12
SJD50
NOMESCO Finland
Production and attachment of palatinal or lingual arrow
9.7
8.8
17
18
ZXA10
NOMESCO Finland
Bilateral
2.1
8.6
98
502
SPB10
NOMESCO Finland
Production of temporary crone to tooth
11.8
8.6
15
13
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
5.3
8.6
25
49
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
4.5
8.5
29
67
SPF20
NOMESCO Finland
Temporary soling for filling
20.4
8.5
12
6
H74.1
ICD-10 Finland
Adhesive middle ear disease
20.4
8.5
12
6
Q36.0
ICD-10 Finland
Cleft lip, bilateral
+∞
8.3
8
*
ECB60
NOMESCO Finland
Reconstruction of alveolus
+∞
8.3
8
*
SJC40
NOMESCO Finland
Removal of orthodontisk device with at most 6 brackets
3.7
8.1
34
96
DCD00
NOMESCO Finland
Myringoplasty
9.1
8.1
16
18
DFF00
NOMESCO Finland
Pure tone audiometry
2.9
8.0
47
170
EBA10
NOMESCO Finland
Surgical removal of tooth
2.0
8.0
105
569
SPC10
NOMESCO Finland
Attachment of standard crone of tooth
7.9
7.9
17
22
J01DA08
ATC
[U] cefaclor; oral
2.0
7.9
104
565
4305
FHL
Tooth extraction by cutting
11.0
7.8
14
13
SPF30
NOMESCO Finland
Soling for prothesis
11.0
7.8
14
13
EFB40
NOMESCO Finland
Removal of internal or external fixation device from facial bones
18.6
7.6
11
6
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
3.8
7.6
30
81
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
3.7
7.5
31
87
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
81.1
7.4
8
*
SJC00
NOMESCO Finland
Bracket with fixed attachment
13.6
7.4
12
9
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
11.0
7.3
13
12
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
5.3
7.3
21
41
Q37.8
ICD-10 Finland
Unspecified cleft palate with bilateral cleft lip
+∞
7.3
7
*
7491F
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOGNATOSCHISIS UNILATERALIS INCOMPLETA]
+∞
7.3
7
*
K07.03
ICD-10 Finland
Micrognatia (hypoplasia) of the upper jaw
+∞
7.3
7
*
Q35.7
ICD-10 Finland
Cleft uvula
+∞
7.3
7
*
74913
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis bilateralis
+∞
7.3
7
*
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
3.4
7.0
32
98
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
7.0
307
2403
H71
ICD-10 Finland
Cholesteatoma of middle ear
14.0
6.9
11
8
SJA03
NOMESCO Finland
Demanding plan for orthodontic care
14.0
6.9
11
8
K07.30
ICD-10 Finland
Spacing, abnormal of tooth or teeth
3.4
6.9
32
99
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.7
6.8
177
1203
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
5.8
6.8
18
32
DLD10
NOMESCO Finland
Reconstruction of cartilage and bone of nose
16.9
6.8
10
6
SJC10
NOMESCO Finland
Orthodontic bandage in one tooth
3.5
6.7
29
85
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
22.8
6.7
9
*
H65.2
ICD-10 Finland
Chronic serous otitis media
6.5
6.7
16
25
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
2.5
6.6
52
224
SJX20
NOMESCO Finland
Check-up visit for orthodontisk therapy
3.7
6.5
26
72
J34.2
ICD-10 Finland
Deviated nasal septum
3.0
6.4
35
122
R49.2
ICD-10 Finland
Hypernasality and hyponasality
70.6
6.4
7
*
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
70.6
6.4
7
*
J01DA06
ATC
[U] cefuroxime; systemic
2.0
6.3
79
420
EH1JB
NOMESCO Finland
Functional examination of palate
+∞
6.3
6
*
4363
FHL
Hidden slit reconstruction
+∞
6.3
6
*
EAB20
NOMESCO Finland
Plastic repair of lip
+∞
6.3
6
*
4379
FHL
Other measure in this category
+∞
6.3
6
*
78353
ICD-8 Finland
Symptoms referable to respiratory system, Rhinolia
+∞
6.3
6
*
H66
ICD-10 Finland
Suppurative and unspecified otitis media
3.2
6.2
30
96
SPF42
NOMESCO Finland
Repair of dental crown, bridge or implant structure, demanding
27.0
6.2
8
*
DLD00
NOMESCO Finland
Reconstruction of cartilage of nose
27.0
6.2
8
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
18
81
2.26
2.56
1.1
1.2
—
—
—
0
0
35
202
1.78
2.54
15.3
11.4
95.8
94.3
%
2.01
35
202
46
292
1.62
2.38
11.5
10.3
122.3
125.3
g/l
0.35
41
278
14
59
2.40
2.30
1.4
1.3
—
—
—
0
0
50
340
1.51
1.96
11.6
10.1
1.2
1.0
mmol/l
0.13
39
264
13
58
2.27
1.92
1.2
1.3
—
—
—
0
0
9
36
2.52
1.74
1.2
1.2
56.0
74.9
u/l
—
9
27
21
118
1.81
1.72
1.0
1.1
—
—
—
0
0
64
853
0.72
1.70
1.3
1.2
12.7
8.3
u/ml
0.21
31
351
30
447
0.65
1.47
2.5
3.3
31.3
31.2
%
0.02
23
312
29
191
1.54
1.37
1.1
1.1
5.1
4.9
u/ml
—
7
33
9
42
2.16
1.34
1.1
3.3
—
—
—
0
0
43
313
1.40
1.26
17.3
9.3
1.1
1.3
mmol/l
1.15
43
298
260
2355
1.18
1.22
3.5
3.0
0.0
0.0
estimate
0.00
46
446
0
35
0.00
1.15
0.0
1.1
—
1.1
—
0
15
259
2356
1.17
1.14
5.0
4.3
0.0
0.0
estimate
0.50
46
462
81
660
1.26
1.12
2.9
2.7
1.1
0.7
e6/l
0.66
46
360
9
163
0.55
1.10
1.2
1.2
—
—
—
0
0
9
163
0.55
1.10
1.2
1.2
—
—
—
0
0
131
1129
1.20
1.08
3.0
3.0
0.3
0.3
e6/l
0.11
107
838
27
187
1.46
1.05
3.9
9.3
25.3
24.4
mmol/l
0.87
22
173
85
705
1.24
1.02
3.6
3.2
271.9
702.1
ng/l
0.79
50
424
260
2385
1.15
1.00
3.5
3.1
0.0
0.0
estimate
0.50
45
441
165
1463
1.17
0.98
3.2
3.2
—
—
—
0
0
0
29
0.00
0.98
0.0
1.0
—
91.9
—
0
16
26
360
0.71
0.93
1.2
1.2
—
21.1
—
0
15
6
29
2.08
0.89
1.0
1.1
1616.0
1610.0
miu/ml
—
6
29
84
709
1.21
0.87
1.7
1.6
440.9
34543013.7
pmol/l
1.07
73
634
394
4129
0.88
0.86
4.4
4.4
38.2
38.1
mmol/mol
0.08
379
3928
325
3447
0.88
0.85
7.3
6.7
84.0
78.3
u/l
0.34
309
3242
28
205
1.38
0.84
2.3
3.1
79.1
104.1
ng/l
0.37
21
183
46
364
1.28
0.84
11.1
7.0
2.0
1.7
mmol/l
0.35
39
287
6
114
0.52
0.83
1.3
1.6
—
—
—
0
0
350
3690
0.88
0.82
3.1
3.1
37.7
38.3
u/l
0.07
339
3540
37
286
1.31
0.80
16.3
10.6
25.3
25.0
mmol/l
0.29
37
286
26
349
0.73
0.79
1.4
1.5
—
—
—
0
0
505
4894
1.17
0.79
11.4
10.9
139.5
139.6
mmol/l
0.05
493
4754
0
24
0.00
0.79
0.0
1.5
—
—
—
0
0
74
871
0.83
0.79
1.3
1.3
18.0
23.8
iu/ml
0.42
22
282
105
1196
0.85
0.77
2.0
2.2
—
—
—
0
0
30
391
0.76
0.76
2.3
2.2
—
19.5
—
0
28
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
0
28
0.00
0.76
0.0
1.0
—
99.3
—
0
15
9
54
1.68
0.74
1.1
1.1
—
—
—
0
0
462
4773
0.88
0.74
3.3
3.5
1.5
1.5
mmol/l
0.04
443
4515
5
25
2.01
0.73
1.0
1.2
761.4
720.2
u/l
—
5
20
122
1084
1.16
0.72
1.5
1.5
—
—
—
0
0
11
68
1.63
0.72
1.7
1.5
—
—
—
0
0
200
1839
1.13
0.71
3.5
3.0
—
—
—
0
0
7
42
1.67
0.68
1.0
2.1
—
—
—
0
0
14
94
1.50
0.67
5.4
6.4
—
2783.5
—
0
10
119
1325
0.87
0.65
3.9
2.5
59.3
55.0
u/l
0.56
110
1238
45
369
1.24
0.64
9.6
6.9
5.9
5.9
kpa
0.11
45
363
21
280
0.74
0.64
1.5
1.7
2.0
3.0
mg/l
0.70
12
192
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
13
87
1.50
0.63
5.5
4.9
0.2
0.3
u/ml
—
6
48
333
3488
0.90
0.62
4.1
3.7
9.7
8.9
mm/h
0.56
315
3271
267
2513
1.11
0.62
5.6
4.8
6.5
6.4
mmol/l
0.15
243
2285
66
566
1.19
0.61
2.7
2.4
2.3
2.4
g/l
0.65
60
522
40
326
1.24
0.61
8.9
6.6
4.9
4.9
kpa
0.08
40
321
444
4578
0.89
0.60
3.0
3.2
1.3
1.3
mmol/l
0.09
425
4324
40
485
0.81
0.60
1.1
1.2
123.3
163.0
iu/ml
0.23
20
203
104
1160
0.88
0.59
2.3
2.1
203.0
245.0
u/l
0.23
97
1104
10
64
1.57
0.59
1.9
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
3.3
—
—
—
0
0
0
23
0.00
0.58
0.0
3.3
—
—
—
0
0
0
23
0.00
0.58
0.0
2.1
—
122.6
—
0
23
91
1023
0.87
0.58
2.3
2.6
339.6
4130.7
umol/l
2.88
81
927
471
4835
0.89
0.57
3.7
3.8
2.9
2.9
mmol/l
0.64
449
4555
8
55
1.46
0.56
1.6
1.7
—
—
—
0
0
61
525
1.18
0.56
1.6
1.6
917.4
1200.6
nmol/l
2.03
47
416
119
1310
0.89
0.55
2.1
2.3
—
—
—
0
0
53
619
0.84
0.55
1.6
1.9
—
—
—
0
0
6
38
1.58
0.54
1.2
1.5
0.9
1.0
g/l
—
6
38
74
649
1.16
0.54
3.0
2.8
2.7
3.0
e6/l
0.11
40
348
467
4792
0.90
0.54
3.4
3.6
4.8
4.8
mmol/l
0.33
447
4550
503
4911
1.12
0.54
11.6
10.9
3.9
3.9
mmol/l
0.43
487
4758
59
681
0.85
0.53
1.8
1.5
—
—
—
0
0
28
345
0.80
0.50
2.7
3.6
4.5
4.7
pmol/l
0.54
28
308
21
268
0.78
0.50
5.8
1.9
43.1
37.7
u/ml
0.09
21
253
19
243
0.77
0.46
1.4
1.4
—
—
—
0
0
21
265
0.79
0.46
2.8
4.4
142.0
23.8
ug/l
0.38
13
210
5
81
0.61
0.46
1.2
1.4
—
—
—
0
0
5
84
0.59
0.45
2.2
2.4
—
—
—
0
0
439
4503
0.91
0.45
3.4
3.4
5.7
5.7
mmol/l
0.15
419
4204
31
258
1.21
0.42
1.5
1.6
—
—
—
0
0
6
92
0.65
0.42
4.2
3.3
18.5
25.1
nmol/l
—
6
87
21
167
1.27
0.42
1.6
1.5
129.7
216.0
u/ml
1.56
13
95
27
326
0.82
0.42
1.4
1.4
—
—
—
0
0
27
326
0.82
0.42
1.4
1.4
—
—
—
0
0
27
326
0.82
0.42
1.4
1.4
—
—
—
0
0
36
305
1.19
0.41
1.4
1.3
230.3
251.2
miu/ml
0.15
21
152
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
27
325
0.82
0.41
1.4
1.4
—
—
—
0
0
5
34
1.47
0.40
1.8
1.6
—
—
—
0
0
528
5361
0.90
0.40
9.0
8.5
27.3
27.9
u/l
0.22
515
5216
177
1667
1.09
0.40
5.1
5.2
36.5
37.2
g/l
0.94
168
1566
7
102
0.68
0.40
1.3
1.1
—
—
—
0
0
22
178
1.24
0.39
2.2
1.4
—
—
—
0
0
5
36
1.39
0.38
1.2
1.0
—
—
—
0
0
316
3049
1.07
0.37
3.8
3.8
1468.2
526.9
e6/l
—
5
36
21
171
1.24
0.36
1.6
1.5
—
—
—
0
0
5
77
0.65
0.36
4.4
2.2
—
—
—
0
0
113
1049
1.09
0.35
2.5
2.3
2.7
2.7
mg/l
0.00
100
899
27
319
0.84
0.35
1.7
2.2
88.6
76.6
ml/min/173m2
—
5
126
66
729
0.89
0.35
5.0
3.3
1229.9
722.9
ng/l
0.45
52
587
182
1726
1.08
0.34
8.6
6.7
1.2
1.2
mmol/l
0.70
167
1591
6
44
1.37
0.34
1.0
1.3
—
—
—
0
0
6
45
1.34
0.34
1.0
1.3
—
—
—
0
0
13
166
0.78
0.33
1.3
1.5
0.2
0.2
g/l
0.02
13
158
21
173
1.22
0.33
1.8
1.5
0.0
0.0
iu/ml
—
6
29
6
46
1.31
0.33
1.8
1.3
—
—
—
0
0
6
47
1.28
0.32
1.0
1.1
—
—
—
0
0
25
212
1.19
0.30
1.4
1.4
—
—
—
0
0
45
401
1.13
0.30
1.3
1.3
261.2
276.5
u/ml
0.04
39
369
44
392
1.13
0.30
1.8
1.7
—
—
—
0
0
11
141
0.78
0.29
1.5
1.8
—
—
—
0
0
130
1226
1.08
0.29
3.6
3.2
0.0
0.0
estimate
1.08
46
455
8
109
0.73
0.29
1.1
1.6
—
—
—
0
0
54
595
0.90
0.29
1.4
1.5
—
—
—
0
0
40
355
1.14
0.29
2.2
2.6
—
—
—
0
0
18
216
0.83
0.28
1.9
2.1
34.1
39.3
u/l
1.06
18
196
12
151
0.79
0.28
1.6
1.9
—
—
—
0
0
115
1081
1.08
0.28
2.2
2.0
—
—
—
0
0
464
4561
1.07
0.28
13.6
12.8
13.4
13.3
%
0.22
455
4489
9
116
0.77
0.27
1.1
1.5
17.9
17.6
u/l
—
9
98
5
72
0.69
0.26
1.2
1.4
—
—
—
0
0
228
2202
1.06
0.25
4.0
3.9
—
—
—
0
0
33
293
1.13
0.24
3.4
5.6
1.1
1.3
mmol/l
0.15
22
207
6
81
0.74
0.24
1.2
1.4
—
—
—
0
0
32
284
1.13
0.24
1.4
1.5
—
—
—
0
0
21
180
1.17
0.24
1.4
1.3
—
—
—
0
0
10
79
1.27
0.22
9.0
4.6
59.6
57.1
%
—
10
79
127
1331
0.94
0.22
2.8
2.8
26.4
38.9
ng/l
0.40
66
644
137
1432
0.94
0.22
1.2
1.4
1.1
1.9
u/ml
0.78
39
350
17
199
0.85
0.22
4.0
4.2
94.2
93.4
%
0.07
17
190
13
107
1.22
0.21
7.4
2.2
0.5
0.8
nmol/l
1.64
13
92
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
73
778
0.93
0.21
1.7
1.4
19.9
20.7
nmol/l
0.18
68
678
14
117
1.20
0.20
1.0
1.1
2.7
1.7
u/ml
—
8
60
129
1234
1.06
0.20
3.2
3.4
8.4
8.5
mmol/l
0.08
114
1088
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
2.0
—
0.2
—
0
9
9
114
0.79
0.20
1.0
1.9
3.7
3.7
mmol/l
—
9
107
388
3944
0.96
0.19
3.8
3.9
14.4
14.4
pmol/l
0.04
368
3665
46
424
1.09
0.19
5.7
5.7
—
—
—
0
0
6
52
1.16
0.19
1.2
1.3
28.6
35.5
nmol/l
—
6
41
42
386
1.09
0.18
1.8
1.7
—
—
—
0
0
35
383
0.91
0.18
1.3
1.3
—
—
—
0
0
111
1062
1.05
0.18
3.9
3.2
1.0
1.0
kg/l
0.82
16
145
7
61
1.15
0.17
1.0
1.4
—
—
—
0
0
22
247
0.89
0.17
1.7
1.7
—
—
—
0
0
80
843
0.94
0.17
2.4
1.8
1.5
1.4
%
0.26
73
779
5
66
0.76
0.17
1.0
1.1
—
—
—
0
0
506
5106
0.95
0.17
11.1
10.5
21.8
20.4
mg/l
0.39
384
3863
507
5115
0.95
0.16
13.1
11.3
40.2
40.8
%
1.13
425
4292
8
69
1.16
0.16
1.0
1.1
—
—
—
0
0
111
1156
0.95
0.16
1.5
1.7
1.3
1.4
mmol/l
0.34
101
1006
164
1591
1.04
0.15
1.7
1.7
—
—
—
0
0
15
131
1.15
0.14
1.2
2.0
—
—
—
0
0
28
305
0.91
0.14
2.1
1.7
—
—
—
0
0
57
539
1.06
0.14
2.6
3.6
4.8
7.5
umol/l
1.81
49
452
11
94
1.17
0.13
2.1
1.7
—
—
—
0
0
9
110
0.82
0.13
1.1
1.6
—
—
—
0
0
452
4476
1.04
0.13
3.8
3.7
—
—
—
0
0
28
303
0.92
0.12
2.4
2.0
—
—
—
0
0
60
571
1.06
0.12
1.8
1.8
—
—
—
0
0
12
137
0.87
0.12
1.7
1.3
61.0
53.6
pmol/l
0.29
12
132
148
1441
1.04
0.12
1.8
1.7
97.7
96.4
pmol/l
0.12
85
757
106
1094
0.96
0.11
1.9
2.0
0.8
1.0
mg/l
0.90
88
804
23
211
1.09
0.11
1.3
1.5
—
—
—
0
0
59
616
0.95
0.10
2.2
2.4
2.4
2.4
mmol/l
0.86
50
536
250
2461
1.03
0.10
2.9
2.8
82.4
90.3
ug/l
0.48
241
2332
5
45
1.11
0.10
1.2
1.2
—
—
—
0
0
5
45
1.11
0.10
1.2
1.2
—
—
—
0
0
5
46
1.09
0.09
1.2
1.2
—
—
—
0
0
5
46
1.09
0.09
1.2
1.2
—
—
—
0
0
5
46
1.09
0.09
1.2
1.2
—
—
—
0
0
16
176
0.91
0.09
10.2
10.4
1.4
1.2
mg/l
0.46
16
167
10
87
1.15
0.09
2.6
6.1
358.7
397.3
umol/l
—
10
78
5
47
1.06
0.09
1.0
1.1
302.0
211.5
mg/l
—
5
41
5
48
1.04
0.09
1.0
1.5
—
—
—
0
0
17
155
1.10
0.09
1.5
1.5
—
240.0
—
0
7
38
400
0.95
0.09
1.4
1.4
—
—
—
0
0
6
58
1.03
0.08
1.2
1.4
—
—
—
0
0
5
65
0.77
0.08
1.0
1.1
—
—
—
0
0
36
342
1.06
0.08
23.6
13.9
1.0
1.2
inr
—
5
67
76
783
0.97
0.08
1.7
2.0
—
—
—
0
0
197
1940
1.02
0.07
8.2
7.1
1.2
1.2
mmol/l
0.41
177
1672
6
70
0.86
0.07
1.0
1.2
—
—
—
0
0
6
72
0.83
0.07
1.0
1.5
—
—
—
0
0
8
75
1.07
0.07
1.4
3.3
39.8
3.4
u/ml
—
8
66
12
108
1.11
0.07
1.1
1.1
—
—
—
0
0
9
103
0.87
0.06
1.2
1.3
—
—
—
0
0
216
2184
0.98
0.06
5.0
6.0
11.1
11.0
umol/l
0.02
203
2074
290
2876
1.02
0.05
8.1
8.8
4.1
3.9
e9/l
0.71
253
2498
459
4609
0.98
0.05
4.3
4.5
1.8
1.8
mu/l
0.64
443
4343
46
472
0.97
0.03
2.7
2.2
0.6
0.6
ug/l
0.12
25
222
23
221
1.04
0.03
1.6
1.7
—
—
—
0
0
451
4497
1.01
0.02
9.4
8.7
92.4
94.3
ml/min/173m2
0.97
352
3591
15
157
0.95
0.01
1.1
1.3
—
—
—
0
0
38
373
1.02
0.01
1.0
1.0
—
—
—
0
0
15
156
0.96
0.00
1.3
1.9
—
—
—
0
0
134
1333
1.01
0.00
2.3
3.0
2.4
2.4
mmol/l
0.50
112
1214
19
184
1.03
0.00
1.3
1.1
—
—
—
0
0
193
1923
1.01
0.00
2.7
2.5
70.0
72.9
nmol/l
0.81
184
1786
24
234
1.03
0.00
1.6
1.3
—
—
—
0
0
10
97
1.03
0.00
1.0
1.2
—
—
—
0
0
63
628
1.00
0.00
3.3
3.2
17.3
20.8
%
1.04
21
200
172
1722
1.00
0.00
3.6
3.3
84.0
31.3
u/l
0.45
164
1648
10
96
1.04
0.00
1.1
1.1
59.6
90.7
iu/ml
—
5
28
13
135
0.96
0.00
2.3
1.6
—
—
—
0
0
22
217
1.01
0.00
1.5
1.5
—
—
—
0
0
17
174
0.98
0.00
2.9
4.4
3.1
3.4
g/l
0.71
17
169
63
634
0.99
0.00
5.1
4.8
0.8
0.8
mmol/l
1.07
57
605
42
422
0.99
0.00
2.2
2.3
5990.3
4497.0
u/l
0.14
18
180
20
204
0.98
0.00
3.2
2.6
0.3
0.1
e6/l
0.91
20
196
15
153
0.98
0.00
1.5
1.7
261.3
215.3
pmol/l
1.07
15
146
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
6
69
0.87
0.00
1.0
1.4
—
—
—
0
0
5
58
0.86
0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
58
0.86
0.00
1.2
1.4
—
—
—
0
0
5
58
0.86
0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
0.00
1.2
1.4
—
—
—
0
0
5
57
0.88
0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
26.6
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
5
58
0.86
0.00
1.2
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CLEFT_LIP_CLEFT_PALATE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CLEFT_LIP_CLEFT_PALATE | 1.527 [1.11, 2.1] | 0.009 |
| Birth year | 0.998 [0.99, 1.01] | 0.627 |
During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 1650 females with Q17_CLEFT_LIP_CLEFT_PALATE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CLEFT_LIP_CLEFT_PALATE | 1.453 [1.11, 1.9] | 0.007 |
| Birth year | 0.99 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 61 out of 1668 males with Q17_CLEFT_LIP_CLEFT_PALATE died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CLEFT_LIP_CLEFT_PALATE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.107% | 0.288% |
| 5 | 0.868% | 1.897% |
| 10 | 2.146% | 4.739% |
| 15 | 4.504% | 8.678% |
| 20 | 8.001% | 14.407% |
Relationships between endpoints
↥Index endpoint: Q17_CLEFT_LIP_CLEFT_PALATE – Cleft lip, lip and palate or palate
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data