cleft lip: ['Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditions
|
519188 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
625 |
4. Check minimum number of eventsNone |
625 |
5. Include endpointsNone |
625 |
6. Filter based on genotype QC (FinnGen only) |
598 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Cleft lip, lip and palate or palate
based on the number of shared cases.
Similar with more cases:
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8348 | 4172 | 4162 |
| Only index persons | 6932 | 3502 | 3430 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.12 | 0.12 |
| Only index persons | 0.13 | 0.13 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 1.21 | 1.31 | 1.00 |
| Only index persons | 1.51 | 1.76 | 1.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 598 | 372 | 226 |
| Unadjusted period prevalence (%) | 0.12 | 0.13 | 0.10 |
| Median age at first event (years) | 2.80 | 2.47 | 3.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 623
- Matched controls
- 6229
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q35.1
ICD-10 Finland
Cleft hard palate
2690.6
199.0
182
*
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
+∞
186.0
169
*
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
+∞
158.2
145
*
4122
FHL
Tympanostomy (tympanic tube)
16.6
125.1
112
81
74920
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis unilateralis
+∞
101.9
95
*
4364
FHL
Pharyngeal tongue plastic
+∞
90.9
85
*
7490A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS COMPLETA]
+∞
88.7
83
*
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
9.3
82.6
109
139
4362
FHL
Nozzle reconstruction
+∞
76.7
72
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
11.8
73.3
79
76
SBB10
NOMESCO Finland
Dental impressions
5.6
71.3
163
368
4361
FHL
Lip plastic or reconstruction due to cleft lip
+∞
71.2
67
*
7492A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS UNILATERALIS COMPLETA]
+∞
71.2
67
*
EB1MA
NOMESCO Finland
Cephalometry with X-ray
9.3
71.0
92
114
EBB10
NOMESCO Finland
Insertion of dental implant
21.7
68.5
52
26
SAA04
NOMESCO Finland
Special examination of mouth
7.0
68.5
117
199
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
7.4
68.1
109
173
EAB30
NOMESCO Finland
Correction of cleft lip
+∞
65.8
62
*
Q37.0
ICD-10 Finland
Cleft hard palate with bilateral cleft lip
+∞
62.6
59
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
14.0
56.0
53
41
Q35.71
ICD-10 Finland
Submucous cleft palate
587.5
55.5
54
*
Q35.9
ICD-10 Finland
Cleft palate, unspecified
575.6
54.4
53
*
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
20.7
50.6
39
20
K00.00
ICD-10 Finland
Hypodontia
12.3
48.8
50
44
74929
ICD-8 Finland
Cleft palate and cleft lip, Unspecified
+∞
48.6
46
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
7.3
48.3
76
117
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
14.7
48.1
44
32
1450
FHL
Otomicroscopy
20.6
47.9
37
19
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.6
46.8
81
138
Q36.9
ICD-10 Finland
Cleft lip, unilateral
+∞
46.4
44
*
ECB17
NOMESCO Finland
Operation of gingival cleft
+∞
45.4
43
*
4368
FHL
Closing the fistula of the mouth
+∞
44.3
42
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
6.2
43.6
80
144
7490C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS SUBMUCOSAE]
+∞
43.2
41
*
7490B
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS INCOMPLETA]
+∞
42.2
40
*
74924
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis bilateralis
+∞
42.2
40
*
4367
FHL
Bone transfer to the upper jaw
+∞
42.2
40
*
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
6.3
39.5
71
125
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
6.8
38.4
63
101
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
7.7
38.3
56
79
7492C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS BILATERALIS COMPLETA]
+∞
36.8
35
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
4.7
36.2
93
225
4365
FHL
Correction of nasal deformity
+∞
35.8
34
*
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
8.0
35.7
50
67
EEC05
NOMESCO Finland
Le Fort I osteotomy
54.7
34.9
41
8
4451
FHL
Guitar cutting
5.0
34.2
79
175
ZSZ10
NOMESCO Finland
Secondary repair operation
179.5
33.0
34
*
UDC00
NOMESCO Finland
Ear microscopy
4.6
33.0
86
210
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
11.6
31.3
33
30
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
5.7
31.2
61
116
74910
ICD-8 Finland
Cleft palate and cleft lip, Cheiloschisis unilateralis
+∞
30.5
29
*
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
10.2
28.8
33
34
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
7.8
28.3
40
54
DLW00
NOMESCO Finland
Correction of cleft nose
+∞
27.3
26
*
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
35.9
26.8
34
10
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
5.8
26.6
51
95
EBB15
NOMESCO Finland
Insertion of dental implant abutment
30.8
26.6
35
12
EHC10
NOMESCO Finland
Plastic repair of oronasal or oroantral fistula of palate
271.3
25.9
26
*
Q35.3
ICD-10 Finland
Cleft soft palate
271.3
25.9
26
*
EHC40
NOMESCO Finland
Repair of submucous cleft palate
271.3
25.9
26
*
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
9.1
25.6
32
37
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
4.7
22.5
55
127
Q37.99
ICD-10 Finland
Cleft palate with cleft lip NOS
+∞
22.0
21
*
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
5.7
21.9
42
78
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
4.9
21.1
48
104
4366
FHL
Upper jaw scar repair surgery
+∞
20.9
20
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
20.8
251
1431
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
33.8
20.3
26
8
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.9
20.2
109
426
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
4.5
20.1
51
121
74912
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis unilateralis
+∞
19.9
19
*
ENC80
NOMESCO Finland
Plastic operation of soft palate for voice distubance
+∞
19.9
19
*
ZXB10
NOMESCO Finland
Medial
21.6
18.8
27
13
Z2221
NOMESCO Finland
Medical doctor
2.2
18.6
211
1163
R1260
NOMESCO Finland
Evaluation of communicative skills
8.1
18.4
25
32
DLD20
NOMESCO Finland
Rhinoplasty
37.9
17.7
22
6
9808
FHL
Bone graft
185.0
17.6
18
*
WZC00
NOMESCO Finland
Treatment plan or consultation
2.1
17.0
253
1537
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.6
17.0
112
483
4347
FHL
Osteotomy of the upper jaw
174.5
16.6
17
*
ZZG00
NOMESCO Finland
Graft of cartilage
174.5
16.6
17
*
K07.14
ICD-10 Finland
Retrognaty, maxillary
20.7
16.5
24
12
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
7.3
16.2
24
34
SAA03
NOMESCO Finland
Extended examination of mouth
2.0
15.9
315
2107
Q37.90
ICD-10 Finland
Unspecified cheft palate with cleft lip, unilateral
+∞
15.7
15
*
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
22.7
15.6
22
10
SXC05
NOMESCO Finland
Other oral or dental procedure
2.8
15.3
82
317
SJC02
NOMESCO Finland
Positioning and fixed attachment of brackets
5.3
15.2
31
61
4204
FHL
Molding of the cartilaginous part of the nose
153.4
14.5
15
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
20.6
13.9
20
10
7491B
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOSCHISIS UNILATERALIS INCOMPLETA]
+∞
13.6
13
*
ZSZ00
NOMESCO Finland
Primary repair operation
+∞
13.6
13
*
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
34.9
13.6
17
5
K08.2
ICD-10 Finland
Atrophy of edentulous alveolar ridge
21.7
13.4
19
9
DCD00
NOMESCO Finland
Myringoplasty
14.2
13.3
22
16
H66.9
ICD-10 Finland
Otitis media, unspecified
2.5
13.2
90
392
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
13.1
210
1286
SJX20
NOMESCO Finland
Orthodontic treatment/control appointment
4.2
13.0
35
87
SPF10
NOMESCO Finland
Demanding reparation of dental prosthesis
23.1
13.0
18
8
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
12.8
295
2028
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
32.8
12.6
16
5
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
3.9
12.6
38
103
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.5
12.6
44
132
SPA10
NOMESCO Finland
Setting attachments on tooth or implanted bracket or imblant based structures
+∞
12.5
12
*
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
24.9
12.5
17
7
SPC20
NOMESCO Finland
Implant borne crown
13.5
12.5
21
16
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
13.5
12.5
21
16
H74.1
ICD-10 Finland
Adhesive middle ear disease
27.3
12.1
16
6
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
3.0
11.8
54
191
4141
FHL
Myringoplasty (also for reasons other than inflammation)
66.2
11.6
13
*
SJC03
NOMESCO Finland
Positioning and fixed attachment of brackets, extensive
4.1
11.6
32
81
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
2.7
11.6
63
245
Q37.3
ICD-10 Finland
Cleft soft palate with unilateral cleft lip
+∞
11.5
11
*
Q35.70
ICD-10 Finland
Cleft uvula
+∞
11.5
11
*
J01DA08
ATC
[U] cefaclor
2.1
11.3
118
616
ZXA10
NOMESCO Finland
Bilateral
2.2
11.2
106
531
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
11.2
161
942
EB1WA, ,
NOMESCO Finland
13.0
11.2
19
15
SPF20
NOMESCO Finland
Temporary relining of dentures
25.5
11.2
15
6
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
44.1
11.0
13
*
H65.2
ICD-10 Finland
Chronic serous otitis media
5.5
10.9
21
39
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
5.0
10.8
23
47
DLD10
NOMESCO Finland
Reconstruction of cartilage and bone of nose
61.1
10.7
12
*
SJC40
NOMESCO Finland
Removal of fixed orthodontic appliance with at most 6 brackets
3.3
10.6
40
126
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
14.5
10.5
17
12
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.3
10.5
41
132
DFF00
NOMESCO Finland
Pure tone audiometry
2.8
10.5
55
210
7491A
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOSCHISIS UNILATERALIS COMPLETA]
+∞
10.4
10
*
7491F
ICD-9 Finland
Cleft palate and cleft lip, Cleft lip[CHEILOGNATOSCHISIS UNILATERALIS INCOMPLETA]
+∞
10.4
10
*
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
11.5
10.1
18
16
H65.0
ICD-10 Finland
Acute serous otitis media
4.7
10.1
23
50
SPC40
NOMESCO Finland
Preparation of first or second intermediate attachment tooth for bridge
20.4
9.8
14
7
SPB10
NOMESCO Finland
Manufacture of a temporary crown to tooth at the dental office
11.6
9.6
17
15
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
4.9
9.6
21
44
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
3.7
9.5
30
84
Q35
ICD-10 Finland
Cleft palate
101.5
9.4
10
*
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
30.5
9.4
12
*
Q36.0
ICD-10 Finland
Cleft lip, bilateral
+∞
9.4
9
*
EHC30
NOMESCO Finland
Reconstruction of palate
+∞
9.4
9
*
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
3.2
9.4
37
120
R4130
NOMESCO Finland
Speech therapy
4.0
9.2
26
67
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
11.7
9.1
16
14
SPB20
NOMESCO Finland
Temporary bridge
15.9
9.1
14
9
SJC10
NOMESCO Finland
Orthodontic band in one tooth
3.3
9.1
35
112
4203
FHL
Mobilization and repositioning of the external pyramid
37.3
9.0
11
*
78159
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Laesio loquendi alia sive NUD
24.4
8.9
12
5
SXC03
NOMESCO Finland
Other oral or dental procedure
10.9
8.8
16
15
DLD00
NOMESCO Finland
Reconstruction of cartilage of nose
50.7
8.7
10
*
ZXE00
NOMESCO Finland
One hour or less
1.7
8.6
237
1667
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
8.5
75
365
Q37.8
ICD-10 Finland
Unspecified cleft palate with bilateral cleft lip
+∞
8.3
8
*
Q35.7
ICD-10 Finland
Cleft uvula
+∞
8.3
8
*
ECB60
NOMESCO Finland
Reconstruction of alveolus
+∞
8.3
8
*
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
3.3
8.2
30
93
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
6.4
8.1
20
32
ZXA05
NOMESCO Finland
Left side
1.9
8.0
108
614
H66
ICD-10 Finland
Suppurative and unspecified otitis media
3.2
8.0
32
105
S02CA02
ATC
flumetasone and antiinfectives; otic
3.1
7.8
32
106
SJB10
NOMESCO Finland
Fitting of removable appliance incl. patient instructions, demanding
4.6
7.7
18
40
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
8.2
7.6
16
20
ZZH22
NOMESCO Finland
Graft of patients own bone, block
18.6
7.6
11
6
Z3229
NOMESCO Finland
Other healthcare associate professional
2.4
7.5
53
234
SPF42
NOMESCO Finland
Repair of dental crown, bridge or implant structure, demanding
81.0
7.4
8
*
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
81.0
7.4
8
*
R49.2
ICD-10 Finland
Hypernasality and hyponasality
81.0
7.4
8
*
SJC00
NOMESCO Finland
Bondable bracket or other fixed attachement
13.6
7.4
12
9
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
7.4
344
2721
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
7.3
7
*
74913
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis bilateralis
+∞
7.3
7
*
K01.0
ICD-10 Finland
Embedded teeth
3.4
7.0
25
76
J34.2
ICD-10 Finland
Deviated nasal septum
2.6
7.0
41
166
SPF30
NOMESCO Finland
Relining of denture
8.4
6.9
14
17
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
3.7
6.8
21
58
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
40.5
6.8
8
*
SPD05
NOMESCO Finland
Mucosa borne complete denture, demanding
40.5
6.8
8
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
16.9
6.8
10
6
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
2.9
6.6
31
112
4305
FHL
Tooth extraction by cutting
7.5
6.4
14
19
78353
ICD-8 Finland
Symptoms referable to respiratory system, Rhinolia
70.5
6.4
7
*
SPC10
NOMESCO Finland
Standard dental crown
5.6
6.3
17
31
4363
FHL
Hidden slit reconstruction
+∞
6.3
6
*
Q37.2
ICD-10 Finland
Cleft soft palate with bilateral cleft lip
+∞
6.3
6
*
4379
FHL
Other measure in this category
+∞
6.3
6
*
EH1JB
NOMESCO Finland
Functional examination of palate
+∞
6.3
6
*
EBA10
NOMESCO Finland
Operative extraction of tooth
1.7
6.2
123
783
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.6
6.2
198
1421
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
3.3
6.1
22
68
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.3
6.1
22
68
SPF00
NOMESCO Finland
Reparation of dental prosthesis without impressions
6.1
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
64
420
1.58
2.86
9.7
8.3
104.78
104.43
mmol/l
0.29
64
420
35
203
1.77
2.50
15.3
11.3
95.81
94.27
%
2.15
35
203
18
82
2.23
2.49
1.1
1.2
—
—
—
0
0
14
59
2.40
2.30
1.4
1.3
—
—
—
0
0
50
341
1.51
1.94
11.6
10.1
1.33
1.01
mmol/l
0.25
41
268
13
58
2.27
1.92
1.2
1.2
—
—
—
0
0
21
118
1.81
1.72
1.0
1.1
—
—
—
0
0
64
850
0.72
1.67
1.3
1.2
12.66
8.29
u/ml
0.21
31
349
6
20
3.02
1.58
1.0
1.1
61.00
82.23
u/l
—
6
20
26
160
1.65
1.58
19.5
12.6
24.98
24.45
mmol/l
0.39
26
155
29
440
0.64
1.54
2.6
3.3
31.48
31.13
%
0.06
23
312
29
191
1.54
1.37
1.1
1.1
5.10
4.94
u/ml
—
7
33
9
44
2.06
1.27
1.1
3.3
—
—
—
0
0
261
2361
1.18
1.25
3.5
3.0
0.00
0.00
estimate
-0.00
48
468
43
318
1.38
1.16
17.3
9.6
1.11
1.34
mmol/l
1.31
43
309
0
35
0.00
1.15
0.0
1.1
—
1.06
—
0
15
259
2356
1.17
1.14
5.0
4.3
0.00
0.00
estimate
0.50
46
461
9
162
0.55
1.10
1.2
1.2
—
—
—
0
0
9
162
0.55
1.10
1.2
1.2
—
—
—
0
0
25
359
0.68
1.07
1.2
1.2
—
21.71
—
0
18
81
666
1.25
1.05
2.9
2.7
1.10
0.73
e6/l
0.63
46
362
131
1135
1.20
1.02
3.0
3.0
0.32
0.28
e6/l
0.12
107
848
85
706
1.24
1.01
3.6
3.2
271.90
702.12
ng/l
0.79
50
424
260
2385
1.15
1.00
3.5
3.1
0.00
0.01
estimate
0.50
45
440
0
29
0.00
0.98
0.0
1.0
—
91.88
—
0
16
165
1469
1.17
0.93
3.2
3.2
—
—
—
0
0
6
29
2.08
0.89
1.0
1.1
1616.00
1609.97
miu/ml
—
6
29
29
390
0.73
0.88
2.3
2.2
—
20.15
—
0
35
8
43
1.87
0.87
1.3
1.4
88.75
74.00
umol/l
—
8
43
84
709
1.21
0.87
1.7
1.6
440.93
34543013.73
pmol/l
1.07
73
634
47
371
1.29
0.87
10.9
7.3
1.92
1.59
mmol/l
0.36
41
297
393
4118
0.88
0.85
4.4
4.3
38.20
38.08
mmol/mol
0.08
378
3917
325
3447
0.88
0.85
7.3
6.7
84.28
78.53
u/l
0.33
311
3249
28
205
1.38
0.84
2.3
3.1
79.10
104.12
ng/l
0.37
21
183
349
3683
0.88
0.84
3.1
3.1
37.69
38.25
u/l
0.06
338
3534
6
114
0.52
0.83
1.3
1.6
—
—
—
0
0
38
295
1.31
0.80
16.1
11.2
25.42
24.96
mmol/l
0.39
38
295
26
349
0.73
0.79
1.4
1.5
—
—
—
0
0
505
4894
1.17
0.79
11.4
10.9
139.54
139.55
mmol/l
0.06
493
4755
0
24
0.00
0.79
0.0
1.5
—
—
—
0
0
0
24
0.00
0.79
0.0
3.3
—
—
—
0
0
0
24
0.00
0.79
0.0
3.3
—
—
—
0
0
6
33
1.83
0.79
1.2
1.3
1.55
1.53
g/l
—
6
33
74
869
0.83
0.77
1.3
1.3
17.99
23.91
iu/ml
0.43
22
290
0
28
0.00
0.76
0.0
1.0
—
99.33
—
0
15
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
9
54
1.68
0.74
1.1
1.1
—
—
—
0
0
122
1081
1.16
0.74
1.5
1.5
—
—
—
0
0
105
1192
0.86
0.74
2.0
2.2
—
—
—
0
0
461
4763
0.88
0.74
3.3
3.5
1.46
1.45
mmol/l
0.05
444
4514
200
1836
1.13
0.73
3.5
3.0
—
—
—
0
0
5
25
2.01
0.73
1.0
1.2
761.40
720.25
u/l
—
5
20
11
68
1.63
0.72
1.7
1.5
—
—
—
0
0
7
42
1.67
0.68
1.0
1.1
—
—
—
0
0
46
376
1.24
0.67
9.4
7.2
5.89
5.85
kpa
0.13
46
370
14
94
1.50
0.67
5.4
6.4
—
2783.50
—
0
10
119
1326
0.87
0.66
3.9
2.6
61.26
56.28
u/l
0.59
111
1241
21
280
0.74
0.64
1.5
1.7
2.20
3.15
mg/l
0.67
13
198
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
13
87
1.50
0.63
5.5
4.9
0.25
0.33
u/ml
—
6
48
443
4571
0.89
0.62
3.0
3.2
1.27
1.26
mmol/l
0.09
424
4317
333
3485
0.90
0.60
4.1
3.7
9.62
8.90
mm/h
0.49
315
3268
66
567
1.18
0.60
2.7
2.4
2.35
2.45
g/l
0.66
60
523
40
485
0.81
0.60
1.1
1.2
123.28
162.95
iu/ml
0.23
20
203
58
678
0.84
0.60
1.8
1.5
—
—
—
0
0
21
157
1.35
0.59
11.9
6.3
0.64
0.68
%
0.20
21
157
0
23
0.00
0.58
0.0
2.1
—
122.61
—
0
23
267
2521
1.10
0.58
5.6
4.9
6.47
6.42
mmol/l
0.14
243
2295
104
1158
0.88
0.57
2.3
2.1
202.98
245.32
u/l
0.24
97
1102
470
4826
0.89
0.57
3.7
3.8
2.93
2.89
mmol/l
0.55
451
4558
91
1021
0.87
0.56
2.3
2.6
339.62
4114.01
umol/l
2.88
81
931
5
89
0.56
0.56
2.4
2.0
129.40
132.29
g/l
—
5
68
8
55
1.46
0.56
1.6
1.7
—
—
—
0
0
61
525
1.18
0.56
1.6
1.6
917.35
1200.58
nmol/l
2.03
47
416
10
65
1.55
0.55
1.9
1.4
—
—
—
0
0
6
37
1.63
0.55
1.2
1.5
0.94
0.99
g/l
—
6
37
466
4784
0.90
0.55
3.4
3.6
4.78
4.75
mmol/l
0.29
448
4553
503
4911
1.12
0.54
11.6
10.9
3.94
3.93
mmol/l
0.44
487
4759
53
617
0.85
0.53
1.6
1.9
—
—
—
0
0
119
1306
0.89
0.53
2.1
2.3
—
—
—
0
0
40
333
1.21
0.52
8.9
6.9
4.86
4.95
kpa
0.10
40
328
28
345
0.80
0.50
2.7
3.6
4.54
4.74
pmol/l
0.57
28
309
74
655
1.15
0.49
3.0
2.8
2.71
2.96
e6/l
0.11
40
350
21
267
0.78
0.49
5.8
2.0
43.07
37.84
u/ml
0.09
21
252
19
243
0.77
0.46
1.4
1.4
—
—
—
0
0
21
265
0.79
0.46
2.8
4.4
141.99
23.81
ug/l
0.38
13
210
5
81
0.61
0.46
1.2
1.4
—
—
—
0
0
5
84
0.59
0.45
1.2
1.7
—
—
—
0
0
5
84
0.59
0.45
1.2
1.7
—
—
—
0
0
5
84
0.59
0.45
2.2
2.4
—
—
—
0
0
438
4494
0.91
0.45
3.4
3.4
5.72
5.69
mmol/l
0.13
418
4195
10
141
0.70
0.45
1.6
1.8
—
—
—
0
0
11
151
0.72
0.43
1.6
1.9
—
—
—
0
0
6
94
0.63
0.42
4.2
3.3
18.50
24.77
nmol/l
—
6
89
27
326
0.82
0.42
1.4
1.4
—
—
—
0
0
27
326
0.82
0.42
1.4
1.4
—
—
—
0
0
27
326
0.82
0.42
1.4
1.4
—
—
—
0
0
36
305
1.19
0.41
1.4
1.3
230.30
251.17
miu/ml
0.15
21
152
65
728
0.88
0.41
5.0
3.3
1229.87
723.85
ng/l
0.45
52
586
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
27
325
0.82
0.41
1.4
1.4
—
—
—
0
0
5
34
1.47
0.40
1.8
1.6
—
—
—
0
0
7
102
0.68
0.40
1.3
1.1
—
—
—
0
0
21
169
1.25
0.39
1.6
1.5
129.69
213.34
u/ml
1.50
13
96
5
36
1.39
0.38
1.2
1.0
—
—
—
0
0
177
1670
1.08
0.38
5.1
5.3
36.47
37.15
g/l
0.95
168
1572
528
5358
0.90
0.38
8.9
8.5
27.32
27.95
u/l
0.26
515
5213
8
111
0.72
0.37
1.1
1.6
—
—
—
0
0
8
115
0.69
0.37
1.1
1.5
12.87
17.73
u/l
—
8
97
5
80
0.62
0.35
4.4
2.2
—
—
—
0
0
113
1050
1.09
0.35
2.5
2.3
2.71
2.71
mg/l
0.00
100
900
6
44
1.37
0.34
1.0
1.3
—
—
—
0
0
27
318
0.84
0.34
1.7
2.2
88.60
76.64
ml/min/173m2
—
5
126
6
45
1.34
0.34
1.0
1.3
—
—
—
0
0
21
173
1.22
0.33
1.6
1.5
—
—
—
0
0
21
173
1.22
0.33
1.8
1.5
0.00
0.04
iu/ml
—
6
29
6
46
1.31
0.33
1.8
1.3
—
—
—
0
0
315
3050
1.07
0.33
3.8
3.8
1468.20
526.94
e6/l
—
5
36
6
47
1.28
0.32
1.0
1.1
—
—
—
0
0
13
165
0.78
0.32
1.3
1.5
0.23
0.23
g/l
0.00
13
157
182
1731
1.07
0.32
8.6
6.9
1.21
1.22
mmol/l
0.81
170
1604
472
4633
1.08
0.32
13.5
12.9
14.08
13.92
%
0.30
464
4569
25
212
1.19
0.30
1.4
1.4
—
—
—
0
0
30
259
1.17
0.30
1.6
1.6
—
—
—
0
0
130
1225
1.08
0.30
3.6
3.2
0.00
0.01
estimate
1.08
46
454
18
216
0.83
0.28
1.9
2.1
34.11
39.31
u/l
1.06
18
196
54
594
0.90
0.28
1.4
1.5
—
—
—
0
0
40
356
1.13
0.28
2.2
2.6
—
—
—
0
0
45
404
1.12
0.27
1.3
1.3
261.16
274.59
u/ml
0.03
39
372
126
1330
0.93
0.26
2.8
2.8
26.68
38.74
ng/l
0.38
65
647
5
74
0.67
0.26
1.2
1.4
—
—
—
0
0
34
301
1.14
0.26
3.5
5.9
1.22
1.27
mmol/l
0.04
23
214
44
398
1.11
0.24
1.8
1.7
—
—
—
0
0
10
78
1.29
0.24
8.7
4.3
4.64
4.04
e9/l
—
10
78
6
83
0.72
0.24
1.2
1.4
—
—
—
0
0
6
84
0.71
0.24
1.3
1.5
6.12
7.43
mmol/l
—
6
74
32
284
1.13
0.24
1.4
1.5
—
—
—
0
0
21
180
1.17
0.24
1.4
1.3
—
—
—
0
0
10
79
1.27
0.22
9.0
4.6
59.60
57.14
%
—
10
79
13
107
1.22
0.21
7.4
2.2
0.49
0.82
nmol/l
1.64
13
92
5
42
1.19
0.21
4.2
2.4
105.80
105.93
mmol/l
—
5
42
73
779
0.93
0.21
1.7
1.4
19.94
20.80
nmol/l
0.21
68
679
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
8
103
0.77
0.21
1.3
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
14
117
1.20
0.20
1.0
1.1
2.74
1.68
u/ml
—
8
60
114
1086
1.06
0.20
2.2
2.1
—
—
—
0
0
242
2487
0.96
0.20
6.8
6.1
28.99
30.07
%
0.89
228
2363
21
183
1.15
0.20
2.2
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
2.0
—
0.20
—
0
9
227
2204
1.05
0.20
2.6
2.5
—
—
—
0
0
9
112
0.80
0.20
1.1
1.6
—
—
—
0
0
9
114
0.79
0.20
1.0
2.2
3.70
3.65
mmol/l
—
9
107
46
423
1.09
0.20
5.7
5.7
—
—
—
0
0
6
52
1.16
0.19
1.2
1.3
28.58
35.52
nmol/l
—
6
41
129
1237
1.05
0.19
3.2
3.4
8.33
8.44
mmol/l
0.08
116
1108
388
3941
0.96
0.18
3.8
3.9
14.41
14.42
pmol/l
0.02
368
3662
111
1061
1.06
0.18
3.9
3.2
1.02
1.02
kg/l
0.82
16
145
7
61
1.15
0.17
1.0
1.4
—
—
—
0
0
22
247
0.89
0.17
1.7
1.7
—
—
—
0
0
506
5107
0.95
0.17
11.1
10.6
21.81
20.45
mg/l
0.38
383
3863
35
381
0.91
0.17
1.3
1.3
—
—
—
0
0
8
69
1.16
0.16
1.0
1.1
—
—
—
0
0
164
1589
1.04
0.16
1.7
1.7
—
—
—
0
0
111
1155
0.95
0.16
1.5
1.7
1.35
1.41
mmol/l
0.33
101
1005
105
1094
0.95
0.16
1.9
2.1
0.78
1.02
mg/l
0.96
88
805
80
840
0.95
0.16
2.4
1.8
1.46
1.41
%
0.25
73
777
15
130
1.16
0.15
1.2
2.0
—
—
—
0
0
139
1436
0.96
0.15
1.2
1.4
1.13
1.91
u/ml
0.78
40
351
42
392
1.08
0.14
1.8
1.7
—
—
—
0
0
28
305
0.91
0.14
2.1
1.7
—
—
—
0
0
16
180
0.89
0.13
10.2
10.6
1.44
1.23
mg/l
0.49
16
171
23
209
1.10
0.13
1.3
1.6
—
—
—
0
0
11
94
1.17
0.13
2.1
1.7
—
—
—
0
0
57
541
1.06
0.12
2.6
3.6
4.82
7.48
umol/l
1.80
49
453
28
303
0.92
0.12
2.4
2.0
—
—
—
0
0
148
1441
1.04
0.12
1.8
1.7
97.66
96.33
pmol/l
0.13
85
756
59
617
0.95
0.11
2.2
2.4
2.44
2.42
mmol/l
0.86
50
537
12
136
0.88
0.11
1.7
1.3
61.00
53.64
pmol/l
0.29
12
131
243
2470
0.97
0.11
6.3
6.0
56.91
55.57
%
1.07
228
2342
250
2461
1.03
0.10
2.9
2.8
82.38
90.19
ug/l
0.47
241
2332
5
45
1.11
0.10
1.2
1.2
—
—
—
0
0
5
45
1.11
0.10
1.2
1.2
—
—
—
0
0
5
46
1.09
0.09
1.2
1.2
—
—
—
0
0
5
46
1.09
0.09
1.2
1.2
—
—
—
0
0
5
46
1.09
0.09
1.2
1.2
—
—
—
0
0
10
87
1.15
0.09
2.6
6.1
358.70
397.31
umol/l
—
10
78
5
47
1.06
0.09
1.0
1.1
302.00
211.49
mg/l
—
5
41
17
155
1.10
0.09
1.5
1.5
—
240.00
—
0
7
38
400
0.95
0.09
1.4
1.4
—
—
—
0
0
160
1569
1.03
0.08
12.7
8.2
1.18
1.12
inr
0.39
45
519
451
4478
1.03
0.08
3.8
3.7
—
—
—
0
0
5
65
0.77
0.08
1.0
1.1
—
—
—
0
0
5
65
0.77
0.08
1.0
1.1
—
—
—
0
0
6
70
0.86
0.07
1.0
1.2
—
—
—
0
0
6
70
0.86
0.07
1.8
2.4
—
—
—
0
0
6
72
0.83
0.07
1.0
1.5
—
—
—
0
0
12
108
1.11
0.07
1.1
1.1
—
—
—
0
0
76
781
0.97
0.07
1.7
2.0
—
—
—
0
0
197
1945
1.02
0.06
8.2
7.3
1.21
1.22
mmol/l
0.44
180
1690
216
2184
0.98
0.06
5.0
6.0
11.90
11.12
umol/l
0.25
203
2075
459
4609
0.98
0.05
4.3
4.5
1.84
1.78
mu/l
0.67
443
4343
59
577
1.02
0.04
1.8
1.8
—
—
—
0
0
46
472
0.97
0.03
2.7
2.2
0.59
0.62
ug/l
0.12
25
222
23
220
1.05
0.03
1.6
1.7
—
—
—
0
0
290
2883
1.01
0.03
8.0
8.8
4.15
3.94
e9/l
0.73
252
2502
171
1721
0.99
0.02
3.6
3.3
84.31
31.47
u/l
0.45
163
1647
451
4499
1.01
0.01
9.4
8.7
92.49
94.31
ml/min/173m2
0.90
353
3599
15
157
0.95
0.01
1.1
1.3
—
—
—
0
0
17
177
0.96
0.01
2.9
4.6
3.05
3.37
g/l
0.66
17
172
588
5886
0.98
0.01
16.5
15.4
40.51
41.64
%
0.75
559
5615
38
373
1.02
0.01
1.0
1.0
—
—
—
0
0
134
1333
1.01
0.00
2.3
3.0
2.36
2.35
mmol/l
0.50
113
1219
19
184
1.03
0.00
1.3
1.1
—
—
—
0
0
63
636
0.99
0.00
5.1
4.8
0.79
0.82
mmol/l
1.11
57
609
588
5885
0.98
0.00
15.8
15.3
267.29
259.45
e9/l
2.21
576
5749
97
964
1.01
0.00
3.8
4.0
7.14
9.47
mg/mmol
0.41
71
644
13
134
0.97
0.00
2.3
1.6
—
—
—
0
0
12
124
0.97
0.00
1.5
1.4
405.14
305.94
ug/g
—
7
64
10
97
1.03
0.00
1.0
1.2
—
—
—
0
0
15
155
0.97
0.00
1.3
1.8
—
—
—
0
0
63
628
1.00
0.00
3.3
3.2
17.27
20.84
%
1.04
21
200
10
96
1.04
0.00
1.1
1.1
59.60
90.65
iu/ml
—
5
28
22
217
1.01
0.00
1.5
1.5
—
—
—
0
0
24
236
1.02
0.00
1.6
1.3
—
—
—
0
0
192
1924
1.00
0.00
2.7
2.5
70.17
72.86
nmol/l
0.75
183
1788
589
5892
0.99
0.00
15.7
15.2
4.61
4.60
e12/l
0.12
577
5751
42
422
0.99
0.00
2.2
2.3
5990.27
4497.05
u/l
0.14
18
180
20
204
0.98
0.00
3.1
2.6
0.30
0.10
e6/l
0.91
20
196
15
153
0.98
0.00
1.5
1.7
261.33
215.28
pmol/l
1.07
15
146
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
5
59
0.85
-0.00
1.2
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
58
0.86
-0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
-0.00
1.0
1.2
85.20
34.12
mg/l
—
5
39
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
69
0.87
-0.00
1.0
1.4
—
—
—
0
0
5
49
1.02
-0.00
1.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
26.60
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CLEFT_LIP_CLEFT_PALATE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CLEFT_LIP_CLEFT_PALATE | 1.527 [1.11, 2.1] | 0.009 |
| Birth year | 0.998 [0.99, 1.01] | 0.627 |
During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 1650 females with Q17_CLEFT_LIP_CLEFT_PALATE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CLEFT_LIP_CLEFT_PALATE | 1.453 [1.11, 1.9] | 0.007 |
| Birth year | 0.99 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 61 out of 1668 males with Q17_CLEFT_LIP_CLEFT_PALATE died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CLEFT_LIP_CLEFT_PALATE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.107% | 0.288% |
| 5 | 0.868% | 1.897% |
| 10 | 2.146% | 4.739% |
| 15 | 4.504% | 8.678% |
| 20 | 8.001% | 14.407% |
Relationships between endpoints
↥Index endpoint: Q17_CLEFT_LIP_CLEFT_PALATE – Cleft lip, lip and palate or palate
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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