obsolete_cleft palate: ['Congenital fissure of the soft and/or hard palate, due to faulty fusion.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
519447 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
402 |
4. Check minimum number of eventsNone |
402 |
5. Include endpointsNone |
402 |
6. Filter based on genotype QC (FinnGen only) |
402 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CLEFT_LIP_CLEFT_PALATE
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Cleft palate
based on the number of shared cases.
Similar with more cases:
- Cleft lip, lip and palate or palate
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5369 | 3001 | 2360 |
| Only index persons | 4471 | 2522 | 1949 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.09 | 0.07 |
| Only index persons | 0.08 | 0.09 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 1.83 | 1.71 | 1.86 |
| Only index persons | 1.89 | 1.81 | 1.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 402 | 277 | 125 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.06 |
| Median age at first event (years) | 2.69 | 2.03 | 4.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 371
- Matched controls
- 3709
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q35.1
ICD-10 Finland
Cleft hard palate
3014.5
189.6
167
*
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
+∞
182.9
160
*
7490A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS COMPLETA]
+∞
82.4
76
*
4364
FHL
Pharyngeal tongue plastic
+∞
75.7
70
*
4362
FHL
Nozzle reconstruction
+∞
58.9
55
*
4122
FHL
Tympanostomy (tympanic tube)
19.8
58.0
90
59
Q35.71
ICD-10 Finland
Submucous cleft palate
+∞
50.1
47
*
Q35.9
ICD-10 Finland
Cleft palate, unspecified
546.0
49.6
48
*
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
519.9
47.4
46
*
7490C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS SUBMUCOSAE]
+∞
42.5
40
*
7490B
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS INCOMPLETA]
+∞
41.4
39
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
13.1
35.4
64
58
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
10.4
32.9
67
77
SJX10
NOMESCO Finland
Short check-up visit for orthodontisk therapy
7.6
28.4
70
110
SAA04
NOMESCO Finland
Special inverstigation of mouth
7.2
28.0
72
120
EB1MA
NOMESCO Finland
Cephalometry with X-ray
9.0
27.0
59
76
Q35.3
ICD-10 Finland
Cleft soft palate
+∞
26.4
25
*
SBB10
NOMESCO Finland
Teeth copy
5.2
25.8
89
214
7492A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS UNILATERALIS COMPLETA]
+∞
24.2
23
*
74920
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis unilateralis
+∞
24.2
23
*
4361
FHL
Lip plastic or reconstruction due to cleft lip
+∞
23.2
22
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
7.7
22.9
55
82
H65.3
ICD-10 Finland
Chronic mucoid otitis media
8.4
22.6
51
69
4451
FHL
Guitar cutting
5.7
21.3
65
134
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
30.1
21.3
28
10
4368
FHL
Closing the fistula of the mouth
+∞
21.0
20
*
1450
FHL
Otomicroscopy
25.1
20.3
28
12
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
13.2
20.0
35
29
Q37.0
ICD-10 Finland
Cleft hard palate with bilateral cleft lip
+∞
20.0
19
*
EBB10
NOMESCO Finland
Insertion of dental implant
24.1
19.4
27
12
EHC40
NOMESCO Finland
Correction of submucous cleft palate
+∞
18.9
18
*
EHC10
NOMESCO Finland
Plastic repair of oronasal or oroantral fistula of palate
+∞
18.9
18
*
EEC05
NOMESCO Finland
Le Fort I osteotomy
99.9
17.7
19
*
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
15.8
17.4
28
19
SJD00
NOMESCO Finland
Removal or reattacment of arrow in fixed orthodontisk device
6.5
17.0
45
77
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
66.5
16.9
19
*
EAB30
NOMESCO Finland
Correction of cleft lip
+∞
16.8
16
*
SJC50
NOMESCO Finland
Removal of orthodontisk device with at least 7 brackets
6.7
16.0
41
67
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
6.5
16.0
42
71
UDC00
NOMESCO Finland
Ear microscopy
5.1
15.5
50
109
SJB00
NOMESCO Finland
Fitting of loose orthodontic device with user information
6.3
14.9
40
70
K00.00
ICD-10 Finland
Hypodontia
11.6
14.7
27
25
ECB17
NOMESCO Finland
Operation for cleft gingiva
+∞
13.6
13
*
74929
ICD-8 Finland
Cleft palate and cleft lip, Unspecified
+∞
13.6
13
*
SJA01
NOMESCO Finland
Estimation of need for orthodontic care
51.9
12.9
15
*
4365
FHL
Correction of nasal deformity
+∞
12.6
12
*
ENC80
NOMESCO Finland
Plastic operation of soft palate for voice distubance
134.3
12.5
13
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
3.3
12.5
66
226
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
38.9
12.3
15
*
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
6.7
12.3
31
50
EBB15
NOMESCO Finland
Insertion of dental implant abutment
27.8
12.1
16
6
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
5.5
11.9
35
69
SJD20
NOMESCO Finland
Attachment of modifiable arrow of fixed orthodontisk device
6.2
11.6
31
54
4367
FHL
Bone transfer to the upper jaw
+∞
11.5
11
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
4.4
11.4
41
101
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
7.8
11.1
25
34
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
44.7
11.0
13
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
44.7
11.0
13
*
SPC20
NOMESCO Finland
Attachment of crone of tooth to implant
29.0
10.8
14
5
H66.9
ICD-10 Finland
Otitis media, unspecified
3.3
10.8
56
189
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
11.7
10.7
19
17
ZSZ10
NOMESCO Finland
Secondary repair operation
113.1
10.5
11
*
74924
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis bilateralis
+∞
10.5
10
*
Q35.70
ICD-10 Finland
Cleft uvula
+∞
10.5
10
*
7492C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS BILATERALIS COMPLETA]
+∞
10.5
10
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.1
10.3
59
213
SAA03
NOMESCO Finland
Extended examination of mouth
2.1
10.3
183
1188
SJD30
NOMESCO Finland
Demanding attachment of arrow to fixed orthodontisk device
6.6
10.0
25
40
SJB60
NOMESCO Finland
External device grinding and adaptation
6.7
9.7
24
38
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
30.9
9.5
12
*
Q35
ICD-10 Finland
Cleft palate
+∞
9.4
9
*
SJD40
NOMESCO Finland
Fixation of ready made palatinal or lingual arrow
4.3
9.1
33
82
78159
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Laesio loquendi alia sive NUD
37.7
9.1
11
*
SJA03
NOMESCO Finland
Demanding plan for orthodontic care
37.7
9.1
11
*
4141
FHL
Myringoplasty (also for reasons other than inflammation)
24.7
9.0
12
5
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
6.2
8.9
23
39
ZXB10
NOMESCO Finland
Medial
14.5
8.8
14
10
SJA04
NOMESCO Finland
Very demanding plan for orthodontic care
51.2
8.7
10
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
51.2
8.7
10
*
EHC30
NOMESCO Finland
Reconstruction of palate
92.0
8.4
9
*
R1260
NOMESCO Finland
Evaluation of communicative skills
13.2
8.4
14
11
DLW00
NOMESCO Finland
Correction of cleft nose
+∞
8.4
8
*
9808
FHL
Bone graft
+∞
8.4
8
*
Q36.9
ICD-10 Finland
Cleft lip, unilateral
+∞
8.4
8
*
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
5.8
8.1
22
40
H74.1
ICD-10 Finland
Adhesive middle ear disease
34.1
8.1
10
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.0
8.0
130
793
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
4.9
7.5
23
49
4347
FHL
Osteotomy of the upper jaw
81.6
7.4
8
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
7.4
166
1129
74912
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis unilateralis
+∞
7.3
7
*
Q35.7
ICD-10 Finland
Cleft uvula
+∞
7.3
7
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
7.3
7
*
K07.14
ICD-10 Finland
Retrognaty, maxillary
16.1
7.3
11
7
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
7.5
7.3
16
22
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
30.6
7.2
9
*
EB1WA
NOMESCO Finland
NA
20.5
7.2
10
5
DCD00
NOMESCO Finland
Myringoplasty
10.3
7.1
13
13
SJD10
NOMESCO Finland
Attachment of arrow to fixed orthodontisk device
3.7
7.1
29
82
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
7.0
206
1523
R4130
NOMESCO Finland
Speech therapy
7.8
7.0
15
20
ZXA10
NOMESCO Finland
Bilateral
2.3
6.9
67
325
SPF10
NOMESCO Finland
Demanding repatation of teeth prosthesis
17.1
6.8
10
6
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
23.0
6.7
9
*
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
23.0
6.7
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
6.5
95
548
R49.2
ICD-10 Finland
Hypernasality and hyponasality
71.0
6.4
7
*
SPF20
NOMESCO Finland
Temporary soling for filling
71.0
6.4
7
*
SPA20
NOMESCO Finland
Selection and insertion of implantdistans
71.0
6.4
7
*
38400
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) acuta
71.0
6.4
7
*
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
6.7
6.4
15
23
4363
FHL
Hidden slit reconstruction
+∞
6.3
6
*
EH1JB
NOMESCO Finland
Functional examination of palate
+∞
6.3
6
*
Q37.99
ICD-10 Finland
Cleft palate with cleft lip NOS
+∞
6.3
6
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.7
6.1
25
71
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
6.9
6.1
14
21
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
13
48
2.77
2.74
1.1
1.3
—
—
—
0
0
29
168
1.78
2.14
8.9
12.9
123.9
124.1
g/l
0.01
24
159
11
43
2.60
2.11
1.5
1.3
—
—
—
0
0
32
196
1.69
1.97
9.4
12.9
1.4
0.8
mmol/l
0.42
22
148
8
29
2.79
1.80
1.1
1.2
—
—
—
0
0
20
110
1.86
1.76
4.4
11.7
25.0
24.2
mmol/l
0.57
15
101
20
115
1.78
1.55
13.2
14.1
0.8
0.7
%
0.34
20
115
20
115
1.78
1.55
13.2
14.0
1.5
1.5
%
0.05
20
115
6
21
2.88
1.51
1.0
4.0
—
—
—
0
0
6
21
2.88
1.51
1.0
1.1
1616.0
1683.3
miu/ml
—
6
21
6
22
2.75
1.44
1.0
1.1
—
—
—
0
0
19
112
1.73
1.38
13.6
14.4
96.2
94.7
%
1.42
19
112
15
82
1.86
1.37
1.0
1.1
—
—
—
0
0
6
23
2.63
1.37
1.0
2.7
—
—
—
0
0
6
23
2.63
1.37
1.0
1.1
—
—
—
0
0
35
479
0.70
1.17
1.7
1.8
—
—
—
0
0
23
150
1.57
1.17
1.7
1.7
—
—
—
0
0
5
20
2.52
1.15
1.2
1.8
1.0
0.9
g/l
—
5
20
326
3102
1.27
1.09
10.3
10.2
139.5
139.5
mmol/l
0.24
317
3008
8
41
1.97
1.09
1.0
1.0
—
—
—
0
0
75
902
0.79
1.03
2.1
2.1
—
—
—
0
0
176
1583
1.20
1.02
4.7
5.2
6.2
6.3
mmol/l
0.31
159
1406
11
62
1.80
0.95
1.7
1.5
—
—
—
0
0
84
988
0.81
0.94
2.2
2.3
—
—
—
0
0
116
1012
1.21
0.92
4.8
5.4
36.3
37.5
g/l
1.44
110
957
325
3112
1.23
0.89
10.4
10.2
3.9
3.9
mmol/l
0.23
313
3005
25
178
1.43
0.88
2.7
5.0
0.9
1.0
mmol/l
0.06
16
123
6
31
1.95
0.84
1.2
1.4
—
—
—
0
0
51
626
0.79
0.84
2.5
2.8
329.0
3786.5
umol/l
1.74
45
576
169
1537
1.17
0.83
5.1
4.4
0.0
0.0
estimate
0.50
27
309
291
3045
0.84
0.82
3.1
3.3
1.5
1.5
mmol/l
0.03
277
2895
135
1209
1.18
0.79
3.5
3.1
—
—
—
0
0
22
301
0.72
0.78
1.5
1.5
—
—
—
0
0
0
28
0.00
0.76
0.0
1.1
—
1.1
—
0
10
44
540
0.79
0.73
1.2
1.3
18.0
8.4
u/ml
0.36
21
222
293
3052
0.85
0.71
3.1
3.3
4.8
4.7
mmol/l
0.75
277
2906
85
970
0.84
0.70
1.2
1.3
0.8
1.6
u/ml
0.95
24
243
13
85
1.55
0.69
7.4
4.3
56.7
52.1
%
0.30
13
85
11
167
0.65
0.67
1.1
1.4
—
—
—
0
0
82
714
1.19
0.67
2.9
3.0
0.4
0.2
e6/l
0.44
68
523
296
3076
0.86
0.67
3.3
3.5
3.0
2.9
mmol/l
0.87
279
2906
61
713
0.83
0.65
1.5
1.6
1.2
1.3
mmol/l
1.12
55
636
23
172
1.36
0.65
13.0
11.2
25.5
24.8
mmol/l
0.53
23
172
280
2919
0.86
0.65
2.8
3.0
1.3
1.2
mmol/l
0.54
266
2768
167
1543
1.14
0.63
3.5
3.1
0.0
0.0
estimate
0.00
28
299
24
182
1.34
0.63
13.5
11.6
1.1
1.4
mmol/l
1.28
24
171
13
187
0.68
0.62
1.5
1.7
3.1
2.8
mg/l
—
7
119
5
30
1.67
0.61
1.2
1.4
—
—
—
0
0
5
30
1.67
0.61
1.2
1.4
—
—
—
0
0
5
30
1.67
0.61
1.2
1.4
—
—
—
0
0
17
232
0.72
0.61
1.8
3.8
4.8
4.8
pmol/l
0.09
17
206
115
1037
1.15
0.61
6.7
7.4
1.2
1.2
mmol/l
0.38
102
954
25
320
0.77
0.60
1.2
1.3
38.6
172.6
iu/ml
4.06
11
135
0
22
0.00
0.59
0.0
1.0
—
99.3
—
0
15
0
23
0.00
0.58
0.0
1.0
—
91.9
—
0
16
19
252
0.74
0.58
1.9
1.8
—
—
—
0
0
168
1560
1.13
0.58
3.6
3.2
0.0
0.0
estimate
0.50
28
293
18
132
1.38
0.58
1.5
1.3
—
—
—
0
0
48
565
0.83
0.56
1.3
1.3
18.4
22.8
iu/ml
0.21
15
182
176
1647
1.12
0.52
3.0
2.9
71.4
75.4
ug/l
0.23
169
1557
43
507
0.83
0.52
1.5
1.5
—
—
—
0
0
42
353
1.21
0.52
2.6
2.4
2.3
2.4
g/l
0.49
37
322
226
2371
0.89
0.51
3.0
3.1
30.0
35.0
u/l
1.84
218
2277
213
2242
0.89
0.51
4.0
3.7
10.1
8.4
mm/h
1.04
201
2101
49
419
1.19
0.51
2.6
3.0
409.8
677.1
ng/l
0.23
25
231
7
107
0.65
0.49
1.1
1.2
—
—
—
0
0
7
106
0.65
0.49
1.1
1.2
—
—
—
0
0
102
927
1.13
0.49
3.2
3.2
—
—
—
0
0
53
606
0.86
0.46
1.8
1.9
—
—
—
0
0
207
2174
0.90
0.46
6.8
6.6
87.4
77.0
u/l
0.40
196
2041
89
807
1.13
0.44
1.5
1.5
—
—
—
0
0
62
698
0.87
0.44
1.9
2.0
153.2
275.7
u/l
0.66
56
664
47
540
0.85
0.44
2.4
1.8
1.4
1.4
%
0.13
42
502
337
3293
1.15
0.43
11.0
10.3
22.1
19.8
mg/l
0.56
266
2469
5
31
1.62
0.43
1.2
1.4
—
—
—
0
0
5
31
1.62
0.43
1.2
1.4
—
—
—
0
0
8
56
1.44
0.43
1.3
1.3
—
—
—
0
0
5
32
1.57
0.42
1.2
1.3
—
—
—
0
0
8
57
1.41
0.42
2.0
4.9
332.0
372.7
umol/l
—
8
49
27
222
1.23
0.42
2.2
2.7
—
—
—
0
0
38
324
1.19
0.42
1.6
1.5
1010.8
1204.4
nmol/l
0.76
29
257
0
15
0.00
0.41
0.0
2.7
—
120.7
—
0
15
20
159
1.27
0.41
1.4
1.4
—
—
—
0
0
5
34
1.48
0.40
1.0
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
23
280
0.81
0.40
1.5
1.4
—
—
—
0
0
23
280
0.81
0.40
1.5
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
3.2
—
662.2
—
0
19
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
23
279
0.81
0.38
1.5
1.4
—
—
—
0
0
23
279
0.81
0.38
1.5
1.4
—
—
—
0
0
10
136
0.73
0.38
1.9
2.0
37.2
41.2
u/l
—
10
125
125
1167
1.10
0.38
7.0
7.8
1.2
1.2
mmol/l
0.37
110
1000
194
1850
1.09
0.38
8.2
8.8
4.3
3.9
e9/l
1.47
173
1620
16
126
1.28
0.35
1.3
1.3
—
—
—
0
0
249
2573
0.91
0.35
3.7
4.1
37.8
37.7
mmol/mol
0.07
236
2456
33
381
0.85
0.34
2.5
2.4
2.4
2.4
mmol/l
0.33
27
330
278
2855
0.91
0.33
3.0
3.2
5.6
5.6
mmol/l
0.01
263
2675
23
273
0.83
0.32
2.2
3.0
31.2
32.7
%
0.27
18
191
7
56
1.25
0.29
11.0
4.6
63.7
57.5
%
—
7
56
303
2964
1.09
0.29
12.9
12.5
13.4
13.3
%
0.16
298
2919
8
106
0.75
0.29
1.6
2.0
—
—
—
0
0
15
184
0.81
0.29
1.5
1.5
—
—
—
0
0
12
94
1.29
0.28
1.3
1.9
—
—
—
0
0
17
140
1.22
0.28
1.5
1.7
—
—
—
0
0
337
3315
1.10
0.27
12.2
11.2
39.9
40.7
%
1.20
283
2816
14
113
1.25
0.27
8.6
7.5
124.9
129.9
g/l
0.47
14
113
129
1353
0.93
0.25
4.3
6.1
11.6
10.6
umol/l
0.25
121
1290
23
198
1.17
0.25
1.6
2.0
—
—
—
0
0
19
223
0.84
0.25
1.2
1.2
—
20.1
—
0
12
9
76
1.19
0.25
1.1
1.1
—
—
—
0
0
72
670
1.09
0.24
2.9
2.3
2.7
2.7
mg/l
0.02
66
578
18
210
0.85
0.22
1.8
1.7
—
—
—
0
0
249
2547
0.94
0.21
3.8
4.0
14.4
14.4
pmol/l
0.06
236
2380
0
11
0.00
0.21
0.0
1.2
—
7.6
—
0
11
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
3.5
—
79.0
—
0
11
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
3.7
—
—
—
0
0
0
10
0.00
0.21
0.0
3.7
—
—
—
0
0
31
345
0.89
0.21
1.4
1.4
—
—
—
0
0
5
43
1.16
0.21
2.6
1.4
—
—
—
0
0
23
261
0.87
0.21
1.0
1.0
—
—
—
0
0
10
123
0.81
0.20
4.4
4.6
89.1
91.8
%
—
10
118
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
15
128
1.18
0.18
1.2
1.1
—
—
—
0
0
294
2985
0.94
0.18
4.2
4.5
1.8
1.7
mu/l
0.33
283
2829
7
60
1.17
0.18
6.1
7.4
—
3848.6
—
0
7
29
264
1.11
0.16
4.0
5.2
—
—
—
0
0
6
77
0.78
0.15
1.0
1.6
3.3
3.5
mmol/l
—
6
72
82
858
0.94
0.15
2.3
3.1
2.4
2.4
mmol/l
0.17
66
780
18
202
0.89
0.14
1.9
1.9
0.5
0.7
ug/l
—
8
88
150
1459
1.04
0.14
4.1
4.1
—
—
—
0
0
8
97
0.82
0.14
1.5
1.9
—
—
—
0
0
47
442
1.07
0.13
1.9
1.6
441.4
55303461.6
pmol/l
1.07
41
396
9
110
0.81
0.13
2.4
1.6
—
—
—
0
0
25
229
1.10
0.12
1.4
1.4
180.2
280.6
miu/ml
1.08
15
123
22
241
0.91
0.12
2.3
2.2
—
22.5
—
0
18
306
3030
1.04
0.10
4.0
3.9
—
—
—
0
0
26
241
1.08
0.10
1.8
1.7
—
—
—
0
0
13
115
1.13
0.10
2.0
1.5
95.0
220.6
u/ml
—
8
68
5
44
1.14
0.10
1.2
1.4
29.9
35.5
nmol/l
—
5
34
5
45
1.11
0.10
2.2
2.4
—
—
—
0
0
83
804
1.04
0.09
3.2
2.7
33.1
54.1
ng/l
0.37
44
343
25
268
0.93
0.09
2.5
2.9
16.0
22.9
%
—
7
79
126
1233
1.03
0.08
2.7
2.5
71.5
73.4
nmol/l
0.34
118
1151
5
61
0.82
0.08
1.0
1.3
—
1.3
—
0
5
39
409
0.95
0.08
4.1
3.5
762.8
715.0
ng/l
0.07
30
319
5
65
0.77
0.08
1.2
1.7
—
—
—
0
0
93
906
1.03
0.08
1.6
1.7
104.4
96.8
pmol/l
0.83
53
480
42
439
0.95
0.08
1.7
1.5
—
—
—
0
0
11
98
1.13
0.07
1.6
1.4
62.8
51.6
pmol/l
0.44
11
93
8
76
1.05
0.07
1.1
1.5
19.9
17.1
u/l
—
8
63
7
80
0.87
0.07
1.1
1.3
—
38.6
—
0
8
13
118
1.11
0.07
1.9
1.4
—
—
—
0
0
43
414
1.04
0.06
3.4
2.6
0.8
0.7
e6/l
0.08
23
219
42
405
1.04
0.06
3.4
2.7
3.5
3.7
e6/l
0.03
23
210
287
2851
1.02
0.05
8.7
8.3
95.3
96.3
ml/min/173m2
0.30
222
2236
11
100
1.10
0.05
2.5
1.5
—
—
—
0
0
15
161
0.93
0.05
1.3
1.6
—
—
—
0
0
344
3425
1.03
0.05
8.4
8.2
26.9
27.1
u/l
0.07
334
3335
82
805
1.02
0.04
3.5
3.3
0.0
0.0
estimate
1.08
28
306
67
681
0.98
0.02
2.0
2.2
0.8
0.9
mg/l
0.38
52
500
26
252
1.03
0.02
1.2
1.3
—
—
—
0
0
70
709
0.98
0.02
2.1
2.0
—
—
—
0
0
36
368
0.98
0.01
1.8
1.8
—
—
—
0
0
12
114
1.05
0.00
7.2
10.2
1.2
1.2
mg/l
0.13
12
108
11
116
0.95
0.00
1.2
1.4
—
—
—
0
0
15
156
0.96
0.00
2.7
4.1
204.4
9.6
ug/l
—
9
120
11
108
1.02
0.00
2.8
4.9
3.0
3.3
g/l
0.42
11
103
13
128
1.02
0.00
1.9
1.9
7.4
6.1
ug/l
0.16
13
117
18
179
1.01
0.00
4.1
2.1
45.7
30.8
u/ml
0.27
18
169
24
241
1.00
0.00
1.6
1.5
—
—
—
0
0
10
97
1.03
0.00
1.4
2.1
—
—
—
0
0
112
1117
1.00
0.00
1.7
1.7
—
—
—
0
0
24
235
1.02
0.00
1.8
1.6
—
—
—
0
0
13
134
0.97
0.00
3.9
2.7
0.3
0.1
e6/l
0.65
13
128
35
354
0.99
0.00
2.1
2.3
1123.7
4801.1
u/l
1.56
15
149
5
52
0.96
0.00
1.0
1.3
—
—
—
0
0
5
52
0.96
0.00
1.0
3.5
61.1
3.4
u/ml
—
5
45
6
61
0.98
0.00
1.0
1.2
—
—
—
0
0
5
51
0.98
0.00
1.2
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
8
83
0.96
0.00
1.0
1.6
492.0
362.3
mg/l
—
8
77
0
7
0.00
0.00
0.0
1.4
—
2.7
—
0
7
6
64
0.94
0.00
1.2
1.7
—
—
—
0
0
9
93
0.97
0.00
1.1
1.2
—
2.6
—
0
5
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
6
69
0.87
0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
0.00
3.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
6
64
0.94
0.00
13.7
2.6
0.6
0.8
nmol/l
—
6
54
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CLEFT_PALATE and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CLEFT_PALATE | 1.685 [1.24, 2.3] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 1196 males with Q17_CLEFT_PALATE died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CLEFT_PALATE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.31% |
| 5 | No data | 2.108% |
| 10 | No data | 4.96% |
| 15 | No data | 9.258% |
| 20 | No data | 15.23% |
Relationships between endpoints
↥Index endpoint: Q17_CLEFT_PALATE – Cleft palate
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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