obsolete_cleft palate: ['Congenital fissure of the soft and/or hard palate, due to faulty fusion.']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditions
|
519188 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
402 |
4. Check minimum number of eventsNone |
402 |
5. Include endpointsNone |
402 |
6. Filter based on genotype QC (FinnGen only) |
386 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CLEFT_LIP_CLEFT_PALATE
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Cleft palate
based on the number of shared cases.
Similar with more cases:
- Cleft lip, lip and palate or palate
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5369 | 3001 | 2360 |
| Only index persons | 4471 | 2522 | 1949 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.09 | 0.07 |
| Only index persons | 0.08 | 0.09 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 1.83 | 1.71 | 1.86 |
| Only index persons | 1.89 | 1.81 | 1.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 386 | 268 | 118 |
| Unadjusted period prevalence (%) | 0.08 | 0.10 | 0.05 |
| Median age at first event (years) | 2.73 | 2.05 | 4.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 401
- Matched controls
- 4010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q35.1
ICD-10 Finland
Cleft hard palate
3357.4
205.7
181
*
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
+∞
192.7
169
*
4122
FHL
Tympanostomy (tympanic tube)
20.6
118.7
98
62
7490A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS COMPLETA]
+∞
90.1
83
*
4364
FHL
Pharyngeal tongue plastic
+∞
77.7
72
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
15.5
76.2
71
55
4362
FHL
Nozzle reconstruction
+∞
65.4
61
*
Q35.71
ICD-10 Finland
Submucous cleft palate
619.1
56.0
54
*
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
+∞
53.3
50
*
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
9.2
53.2
71
92
Q35.9
ICD-10 Finland
Cleft palate, unspecified
579.4
52.7
51
*
EB1MA
NOMESCO Finland
Cephalometry with X-ray
9.5
49.3
63
77
SJX10
NOMESCO Finland
Orthodontic treatment/control appointment, short
7.8
48.1
74
113
SAA04
NOMESCO Finland
Special examination of mouth
7.4
46.8
76
123
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
15.8
44.8
40
28
7490C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS SUBMUCOSAE]
+∞
43.5
41
*
7490B
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS INCOMPLETA]
+∞
42.5
40
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
8.5
41.0
57
77
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
7.6
40.8
63
96
SBB10
NOMESCO Finland
Dental impressions
4.9
36.6
97
246
4451
FHL
Guitar cutting
6.0
34.7
68
132
K00.00
ICD-10 Finland
Hypodontia
11.5
28.1
30
28
74920
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis unilateralis
+∞
26.3
25
*
7492A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS UNILATERALIS COMPLETA]
+∞
26.3
25
*
Q35.3
ICD-10 Finland
Cleft soft palate
277.5
26.0
26
*
4361
FHL
Lip plastic or reconstruction due to cleft lip
+∞
25.3
24
*
SJD00
NOMESCO Finland
Removal and/or reactivation of orthodontic arch wire
5.9
25.1
48
90
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.1
25.1
46
83
SJC50
NOMESCO Finland
Removal of fixed orthodontic appliance with at least 7 brackets
6.6
24.7
42
70
SJB00
NOMESCO Finland
Fitting of removable appliance incl. patient instructions
6.1
23.6
43
77
Q37.0
ICD-10 Finland
Cleft hard palate with bilateral cleft lip
+∞
23.1
22
*
UDC00
NOMESCO Finland
Ear microscopy
4.7
22.7
57
136
4368
FHL
Closing the fistula of the mouth
+∞
22.1
21
*
1450
FHL
Otomicroscopy
23.9
20.7
29
13
EBB10
NOMESCO Finland
Insertion of dental implant
20.1
20.3
30
16
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
20.1
20.3
30
16
EAB30
NOMESCO Finland
Correction of cleft lip
+∞
20.0
19
*
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
6.1
19.3
35
62
EHC40
NOMESCO Finland
Repair of submucous cleft palate
198.9
18.7
19
*
EHC10
NOMESCO Finland
Plastic repair of oronasal or oroantral fistula of palate
188.0
17.7
18
*
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
14.8
17.6
29
21
SJD20
NOMESCO Finland
Placement of modified orthodontic arch wire
6.0
17.6
32
57
EEC05
NOMESCO Finland
Le Fort I osteotomy
66.3
16.9
19
*
ECB17
NOMESCO Finland
Operation of gingival cleft
+∞
16.8
16
*
SJD30
NOMESCO Finland
Demanding placement of orthodontic arch wire
7.1
16.8
26
39
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
7.3
16.7
25
36
ENC80
NOMESCO Finland
Plastic operation of soft palate for voice distubance
+∞
15.7
15
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.9
14.8
47
133
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.9
14.6
82
331
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
11.0
14.5
27
26
EBB15
NOMESCO Finland
Insertion of dental implant abutment
28.4
14.4
19
7
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
23.3
14.4
20
9
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.0
14.2
71
268
SJB60
NOMESCO Finland
Adjustment and grinding of removable appliance
5.5
13.6
27
52
74929
ICD-8 Finland
Cleft palate and cleft lip, Unspecified
+∞
13.6
13
*
SJA01
NOMESCO Finland
Assesment of orthodontic treatment need
41.6
13.2
16
*
SJD40
NOMESCO Finland
Placement of prefabricated palatal or lingual arch
4.3
12.8
34
84
H66.9
ICD-10 Finland
Otitis media, unspecified
2.9
12.7
68
266
4367
FHL
Bone transfer to the upper jaw
+∞
12.6
12
*
4365
FHL
Correction of nasal deformity
+∞
12.6
12
*
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
27.7
12.1
16
6
DCD00
NOMESCO Finland
Myringoplasty
22.1
12.1
17
8
ZSZ10
NOMESCO Finland
Secondary repair operation
67.0
11.7
13
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
4.3
11.6
31
77
Q35.70
ICD-10 Finland
Cleft uvula
+∞
11.5
11
*
74924
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis bilateralis
+∞
11.5
11
*
7492C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS BILATERALIS COMPLETA]
+∞
11.5
11
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.5
11.4
42
131
ZXB10
NOMESCO Finland
Medial
17.7
11.3
17
10
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
28.9
10.8
14
5
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
61.7
10.7
12
*
4141
FHL
Myringoplasty (also for reasons other than inflammation)
61.7
10.7
12
*
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
11.0
10.4
19
18
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
10.0
10.4
20
21
SPC20
NOMESCO Finland
Implant borne crown
19.4
10.3
15
8
SJD10
NOMESCO Finland
Placement of orthodontic arch wire
3.9
10.2
31
85
H74.1
ICD-10 Finland
Adhesive middle ear disease
41.2
10.0
12
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
20.7
9.9
14
7
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
8.7
9.7
20
24
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
9.7
148
906
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
9.6
160
1007
Q35
ICD-10 Finland
Cleft palate
102.4
9.5
10
*
SJA03
NOMESCO Finland
Demanding workplan for orthodontic treatment
30.8
9.5
12
*
SAA03
NOMESCO Finland
Extended examination of mouth
1.9
9.4
206
1420
EHC30
NOMESCO Finland
Reconstruction of palate
+∞
9.4
9
*
Q36.9
ICD-10 Finland
Cleft lip, unilateral
+∞
9.4
9
*
ZXA10
NOMESCO Finland
Bilateral
2.4
9.1
71
332
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
16.1
9.1
14
9
78159
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Laesio loquendi alia sive NUD
37.6
9.1
11
*
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
4.2
8.6
23
57
R1260
NOMESCO Finland
Evaluation of communicative skills
10.4
8.6
16
16
SPF10
NOMESCO Finland
Demanding reparation of dental prosthesis
28.2
8.5
11
*
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
20.6
8.5
12
6
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
4.8
8.4
19
41
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
8.4
192
1326
4347
FHL
Osteotomy of the upper jaw
+∞
8.4
8
*
DLW00
NOMESCO Finland
Correction of cleft nose
+∞
8.4
8
*
Q35.7
ICD-10 Finland
Cleft uvula
+∞
8.4
8
*
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
3.9
8.3
25
68
J01DA08
ATC
[U] cefaclor
2.2
8.1
82
428
SJC01
NOMESCO Finland
Positioning and fixed attachment of single bracket (Bracket with fixed attachment)
3.8
7.9
24
66
DFF00
NOMESCO Finland
Pure tone audiometry
3.0
7.8
36
129
S02CA02
ATC
flumetasone and antiinfectives; otic
3.6
7.8
26
76
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
18.8
7.6
11
6
K07.14
ICD-10 Finland
Retrognaty, maxillary
18.8
7.6
11
6
Z2221
NOMESCO Finland
Medical doctor
1.9
7.6
126
781
SJA04
NOMESCO Finland
Very demanding workplan for orthodontic treatment
25.6
7.6
10
*
SPF20
NOMESCO Finland
Temporary relining of dentures
25.6
7.6
10
*
SJX21
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment
3.9
7.5
22
59
9808
FHL
Bone graft
81.5
7.4
8
*
R49.2
ICD-10 Finland
Hypernasality and hyponasality
81.5
7.4
8
*
74912
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathoschisis unilateralis
+∞
7.3
7
*
Q37.99
ICD-10 Finland
Cleft palate with cleft lip NOS
+∞
7.3
7
*
K01.0
ICD-10 Finland
Embedded teeth
4.1
7.2
20
51
H65.2
ICD-10 Finland
Chronic serous otitis media
6.8
7.2
17
26
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
6.9
232
1763
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.8
6.7
33
123
SJX11
NOMESCO Finland
Therapeutic intervention or check-up related to orthodontic treatment, restricted
3.2
6.6
26
85
ZZG00
NOMESCO Finland
Graft of cartilage
70.9
6.4
7
*
H65.0
ICD-10 Finland
Acute serous otitis media
5.7
6.4
17
31
SJD50
NOMESCO Finland
Placement of prefabricated palatal or lingual arch, dentist-made
9.5
6.3
12
13
4741B
ICD-9 Finland
Chronic disease of tonsils and adenoids, Hypertrophy of tonsils and adenoids[HYPERTROPHIA TONSILLAE PHARYNGICAE]
3.8
6.3
19
52
Q37.90
ICD-10 Finland
Unspecified cheft palate with cleft lip, unilateral
+∞
6.3
6
*
EH1JB
NOMESCO Finland
Functional examination of palate
+∞
6.3
6
*
4363
FHL
Hidden slit reconstruction
+∞
6.3
6
*
Q37.3
ICD-10 Finland
Cleft soft palate with unilateral cleft lip
+∞
6.3
6
*
SPA20
NOMESCO Finland
Selection and insertion of implant abutment
27.1
6.2
8
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.7
6.2
143
969
SXC05
NOMESCO Finland
Other oral or dental procedure
2.3
6.2
48
223
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
12.8
6.1
10
8
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
6.2
6.1
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
13
48
2.77
2.74
1.1
1.3
—
—
—
0
0
39
245
1.66
2.17
8.3
10.0
104.82
104.54
mmol/l
0.15
39
245
11
43
2.60
2.09
1.5
1.3
—
—
—
0
0
32
197
1.68
1.93
9.4
12.8
1.55
0.79
mmol/l
0.68
24
151
8
29
2.79
1.80
1.1
1.2
—
—
—
0
0
20
116
1.76
1.51
13.2
14.0
0.77
0.71
%
0.32
20
116
20
116
1.76
1.51
13.2
13.9
1.52
1.49
%
0.05
20
116
6
21
2.88
1.51
1.0
1.1
1616.00
1683.33
miu/ml
—
6
21
6
22
2.75
1.44
1.0
1.1
—
—
—
0
0
15
82
1.86
1.37
1.0
1.1
—
—
—
0
0
6
23
2.63
1.37
1.0
1.2
—
—
—
0
0
6
23
2.63
1.37
1.0
1.1
—
—
—
0
0
6
23
2.63
1.37
1.0
3.9
—
—
—
0
0
5
17
2.96
1.36
1.2
1.4
1.57
1.47
g/l
—
5
17
19
113
1.72
1.34
13.6
14.3
96.23
94.55
%
1.58
19
113
35
479
0.70
1.17
1.7
1.8
—
—
—
0
0
5
20
2.52
1.15
1.2
1.8
0.97
0.87
g/l
—
5
20
8
41
1.97
1.09
1.0
1.0
—
—
—
0
0
326
3104
1.27
1.07
10.3
10.3
139.46
139.55
mmol/l
0.26
317
3011
75
901
0.79
1.02
2.1
2.1
—
—
—
0
0
176
1589
1.19
0.97
4.7
5.4
6.22
6.34
mmol/l
0.33
159
1413
11
62
1.80
0.95
1.7
1.5
—
—
—
0
0
84
987
0.81
0.94
2.2
2.3
—
—
—
0
0
22
151
1.48
0.92
1.8
1.7
—
—
—
0
0
106
918
1.21
0.91
11.5
8.1
1.15
1.10
inr
0.28
30
324
116
1014
1.20
0.90
4.8
5.5
36.29
37.53
g/l
1.44
110
962
26
186
1.43
0.90
2.8
5.4
1.04
0.96
mmol/l
0.04
17
131
325
3114
1.23
0.87
10.4
10.3
3.93
3.92
mmol/l
0.24
313
3008
387
3795
1.57
0.87
15.3
15.0
271.60
260.84
e9/l
2.57
380
3713
290
3037
0.84
0.84
3.1
3.3
1.46
1.46
mmol/l
0.05
278
2894
169
1536
1.17
0.83
5.1
4.4
0.00
0.00
estimate
0.50
27
309
135
1205
1.18
0.83
3.5
3.1
—
—
—
0
0
387
3798
1.54
0.82
15.3
14.9
4.59
4.58
e12/l
0.25
381
3711
51
624
0.79
0.82
2.5
2.8
329.04
3768.12
umol/l
1.74
45
579
22
301
0.72
0.78
1.5
1.5
—
—
—
0
0
0
28
0.00
0.76
0.0
1.1
—
1.06
—
0
10
292
3046
0.85
0.74
3.1
3.3
4.79
4.72
mmol/l
0.66
278
2908
386
3793
1.47
0.72
15.9
15.2
40.22
40.68
%
0.78
366
3630
44
537
0.80
0.70
1.2
1.3
18.05
8.48
u/ml
0.35
21
220
279
2913
0.86
0.68
2.8
3.0
1.26
1.22
mmol/l
0.50
265
2762
295
3067
0.86
0.67
3.3
3.5
2.94
2.87
mmol/l
0.72
281
2907
11
167
0.65
0.67
1.1
1.4
—
—
—
0
0
168
1547
1.15
0.67
3.5
3.1
0.00
0.00
estimate
-0.00
30
313
13
86
1.53
0.67
7.4
4.3
56.74
52.11
%
0.30
13
86
61
713
0.83
0.65
1.5
1.7
1.19
1.35
mmol/l
1.17
55
636
24
181
1.35
0.65
12.8
12.2
25.59
24.81
mmol/l
0.70
24
181
17
233
0.72
0.63
1.8
3.8
4.75
4.83
pmol/l
0.11
17
207
82
720
1.17
0.61
2.9
3.0
0.39
0.22
e6/l
0.45
68
530
86
970
0.86
0.61
1.2
1.3
0.81
1.59
u/ml
0.95
24
243
13
186
0.69
0.61
1.5
1.7
3.13
3.18
mg/l
—
7
123
25
320
0.77
0.60
1.2
1.3
38.59
172.57
iu/ml
4.06
11
135
0
22
0.00
0.59
0.0
1.0
—
99.33
—
0
15
168
1559
1.13
0.59
3.6
3.2
0.00
0.01
estimate
0.50
28
293
0
23
0.00
0.58
0.0
1.0
—
91.88
—
0
16
19
252
0.74
0.58
1.9
1.8
—
—
—
0
0
115
1043
1.14
0.57
6.7
7.6
1.21
1.22
mmol/l
0.67
104
966
11
73
1.52
0.56
1.5
1.4
439.17
311.01
ug/g
—
6
36
24
186
1.31
0.56
13.5
12.1
1.12
1.43
mmol/l
1.46
24
180
225
2366
0.89
0.54
3.1
3.1
30.03
35.01
u/l
1.84
217
2272
48
563
0.83
0.54
1.3
1.3
18.36
22.63
iu/ml
0.20
15
184
176
1645
1.12
0.54
3.0
2.9
71.45
75.45
ug/l
0.23
169
1555
18
134
1.36
0.54
1.5
1.3
—
—
—
0
0
43
507
0.83
0.52
1.5
1.5
—
—
—
0
0
49
418
1.20
0.52
2.6
3.0
409.84
677.06
ng/l
0.23
25
231
42
354
1.21
0.50
2.6
2.4
2.35
2.45
g/l
0.50
37
323
213
2240
0.90
0.50
4.0
3.7
10.09
8.47
mm/h
0.96
201
2099
7
107
0.65
0.49
1.1
1.2
—
—
—
0
0
7
106
0.65
0.49
1.7
2.0
—
—
—
0
0
7
106
0.65
0.49
1.1
1.2
—
—
—
0
0
53
606
0.86
0.46
1.8
1.9
—
—
—
0
0
207
2174
0.90
0.46
6.6
6.6
87.88
77.47
u/l
0.40
197
2045
102
932
1.13
0.45
3.2
3.2
—
—
—
0
0
89
807
1.13
0.44
1.5
1.5
—
—
—
0
0
38
322
1.20
0.44
1.6
1.5
1010.79
1205.94
nmol/l
0.77
29
255
5
31
1.62
0.43
1.2
1.4
—
—
—
0
0
62
696
0.87
0.43
1.9
2.0
153.23
276.42
u/l
0.66
56
662
8
56
1.44
0.43
2.0
4.9
332.00
372.94
umol/l
—
8
48
5
32
1.57
0.42
1.2
1.2
—
—
—
0
0
47
537
0.86
0.41
2.4
1.8
1.40
1.36
%
0.13
42
499
0
15
0.00
0.41
0.0
2.7
—
120.73
—
0
15
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
20
159
1.27
0.41
1.4
1.4
—
—
—
0
0
337
3296
1.14
0.41
10.9
10.3
22.07
19.85
mg/l
0.54
265
2471
27
223
1.23
0.41
2.2
2.7
—
—
—
0
0
5
34
1.48
0.40
1.0
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
23
280
0.81
0.40
1.5
1.4
—
—
—
0
0
23
280
0.81
0.40
1.5
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
3.2
—
662.21
—
0
19
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
23
279
0.81
0.38
1.5
1.4
—
—
—
0
0
23
279
0.81
0.38
1.5
1.4
—
—
—
0
0
10
136
0.73
0.38
1.9
2.0
37.20
41.21
u/l
—
10
125
16
126
1.28
0.35
1.3
1.3
—
—
—
0
0
194
1854
1.09
0.35
8.2
8.9
4.31
3.91
e9/l
1.49
172
1621
248
2563
0.92
0.35
3.7
4.1
37.80
37.67
mmol/mol
0.07
235
2446
18
222
0.80
0.35
1.2
1.2
—
18.98
—
0
13
125
1173
1.10
0.34
7.0
8.0
1.21
1.22
mmol/l
0.33
113
1012
33
381
0.85
0.34
2.5
2.4
2.43
2.41
mmol/l
0.31
27
330
277
2846
0.91
0.34
3.0
3.2
5.61
5.62
mmol/l
0.04
262
2666
17
137
1.25
0.32
1.5
1.7
—
—
—
0
0
7
97
0.72
0.31
1.6
1.9
—
—
—
0
0
7
56
1.25
0.29
11.0
4.6
63.71
57.52
%
—
7
56
7
56
1.25
0.29
1.3
1.3
—
—
—
0
0
15
184
0.81
0.29
1.5
1.5
—
—
—
0
0
7
57
1.23
0.29
1.6
1.6
8.90
7.11
mmol/l
—
7
57
12
94
1.29
0.28
1.3
1.9
—
—
—
0
0
23
268
0.85
0.27
2.2
3.1
31.39
32.61
%
0.21
18
192
129
1354
0.93
0.26
4.2
6.2
12.98
10.78
umol/l
0.49
121
1292
23
198
1.17
0.25
1.6
2.0
—
—
—
0
0
12
96
1.26
0.25
9.3
8.1
0.66
0.69
%
0.12
12
96
9
76
1.19
0.25
1.1
1.1
—
—
—
0
0
72
670
1.09
0.24
2.9
2.3
2.70
2.71
mg/l
0.02
66
577
18
210
0.85
0.22
1.8
1.7
—
—
—
0
0
14
116
1.21
0.22
8.6
8.7
124.86
129.42
g/l
0.41
14
116
0
11
0.00
0.21
0.0
3.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
3.5
—
79.00
—
0
11
0
11
0.00
0.21
0.0
3.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
7.62
—
0
11
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
31
345
0.89
0.21
1.4
1.4
—
—
—
0
0
21
240
0.87
0.21
2.3
2.2
—
23.08
—
0
21
74
696
1.08
0.20
3.4
3.3
1.02
1.02
kg/l
—
10
93
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
23
260
0.88
0.20
1.0
1.0
—
—
—
0
0
249
2542
0.95
0.19
3.8
4.0
14.40
14.42
pmol/l
0.04
236
2375
15
128
1.18
0.18
1.2
1.1
—
—
—
0
0
7
60
1.17
0.18
6.1
7.4
—
3848.57
—
0
7
5
67
0.74
0.17
1.2
1.7
—
—
—
0
0
29
264
1.11
0.16
4.0
5.2
—
—
—
0
0
294
2981
0.95
0.16
4.2
4.5
1.80
1.75
mu/l
0.36
283
2825
6
78
0.77
0.15
1.0
1.9
3.33
3.52
mmol/l
—
6
73
38
409
0.92
0.15
4.2
3.5
762.77
714.97
ng/l
0.07
30
319
18
202
0.89
0.14
1.9
1.9
0.48
0.67
ug/l
—
8
88
41
439
0.93
0.14
1.7
1.5
—
—
—
0
0
47
441
1.07
0.14
1.9
1.6
441.41
55443469.55
pmol/l
1.07
41
395
82
856
0.95
0.14
2.3
3.1
2.36
2.35
mmol/l
0.12
66
781
25
228
1.10
0.13
1.4
1.4
180.18
276.24
miu/ml
1.02
15
122
162
1581
1.04
0.13
6.5
6.1
57.61
55.32
%
1.70
152
1503
9
110
0.81
0.13
2.4
1.6
—
—
—
0
0
35
374
0.93
0.12
1.9
1.8
—
—
—
0
0
163
1597
1.03
0.10
7.1
6.2
28.78
30.48
%
1.24
155
1524
5
44
1.14
0.10
1.2
1.4
29.88
35.47
nmol/l
—
5
34
5
44
1.14
0.10
2.2
2.4
—
—
—
0
0
5
44
1.14
0.10
2.6
1.4
—
—
—
0
0
149
1460
1.03
0.09
2.6
2.6
—
—
—
0
0
13
116
1.12
0.09
2.0
1.5
95.00
216.85
u/ml
—
8
69
25
268
0.93
0.09
2.5
2.9
16.00
22.91
%
—
7
79
93
904
1.04
0.09
1.6
1.7
104.44
96.70
pmol/l
0.85
53
480
11
97
1.14
0.09
1.6
1.4
62.82
51.91
pmol/l
0.43
11
92
69
713
0.96
0.08
2.1
2.1
—
—
—
0
0
5
60
0.83
0.08
1.0
1.3
—
1.28
—
0
5
66
681
0.96
0.07
2.0
2.2
0.78
0.96
mg/l
0.43
52
500
305
3030
1.03
0.06
4.0
3.9
—
—
—
0
0
344
3423
1.03
0.06
8.3
8.3
26.85
27.16
u/l
0.09
334
3333
13
119
1.10
0.06
1.9
1.4
—
—
—
0
0
26
247
1.06
0.05
1.8
1.7
—
—
—
0
0
82
803
1.03
0.05
3.2
2.7
33.72
53.85
ng/l
0.35
43
345
15
161
0.93
0.05
1.3
1.6
—
—
—
0
0
287
2852
1.02
0.05
8.6
8.3
95.56
96.38
ml/min/173m2
0.23
223
2243
82
804
1.03
0.05
3.5
3.3
0.00
0.01
estimate
1.08
28
306
125
1234
1.02
0.04
2.8
2.5
71.72
73.34
nmol/l
0.28
117
1152
56
549
1.02
0.03
3.6
4.1
6.32
9.93
mg/mmol
0.53
39
377
43
420
1.03
0.02
3.4
2.7
0.77
0.72
e6/l
0.06
23
221
42
411
1.02
0.02
3.4
2.7
3.53
3.63
e6/l
0.02
23
212
26
252
1.03
0.02
1.2
1.3
—
—
—
0
0
11
116
0.95
0.00
1.2
1.4
—
—
—
0
0
12
118
1.02
0.00
7.2
10.5
1.19
1.21
mg/l
0.08
12
112
13
128
1.02
0.00
1.9
1.9
7.37
6.09
ug/l
0.16
13
117
18
178
1.01
0.00
4.1
2.1
45.74
30.92
u/ml
0.27
18
168
11
111
0.99
0.00
2.8
5.2
3.03
3.31
g/l
0.37
11
106
24
241
1.00
0.00
1.6
1.5
—
—
—
0
0
24
241
1.00
0.00
1.8
1.6
—
—
—
0
0
10
105
0.95
0.00
2.7
1.4
—
—
—
0
0
15
155
0.97
0.00
2.7
4.1
204.42
9.68
ug/l
—
9
119
10
96
1.04
0.00
1.4
2.0
—
—
—
0
0
112
1115
1.01
0.00
1.7
1.7
—
—
—
0
0
13
134
0.97
0.00
3.9
2.7
0.26
0.10
e6/l
0.65
13
128
35
354
0.99
0.00
2.1
2.3
1123.72
4801.13
u/l
1.56
15
149
6
69
0.87
0.00
1.3
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
6
64
0.94
0.00
13.7
2.6
0.64
0.82
nmol/l
—
6
54
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
2.69
—
0
7
7
79
0.88
-0.00
1.1
1.2
—
38.59
—
0
8
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
61
0.98
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
75
0.93
-0.00
1.1
1.5
14.40
17.25
u/l
—
7
62
5
52
0.96
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
92
0.98
-0.00
1.1
1.2
—
2.62
—
0
5
5
53
0.94
-0.00
1.2
1.6
—
—
—
0
0
6
66
0.91
-0.00
1.2
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
53
0.94
-0.00
3.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
52
0.96
-0.00
1.0
3.5
61.06
6.06
u/ml
—
5
52
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
84
0.95
-0.00
1.0
1.9
492.00
357.49
mg/l
—
8
78
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CLEFT_PALATE and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CLEFT_PALATE | 1.685 [1.24, 2.3] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 1196 males with Q17_CLEFT_PALATE died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CLEFT_PALATE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.31% |
| 5 | No data | 2.108% |
| 10 | No data | 4.96% |
| 15 | No data | 9.258% |
| 20 | No data | 15.23% |
Relationships between endpoints
↥Index endpoint: Q17_CLEFT_PALATE – Cleft palate
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data