No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
519447 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
183 |
4. Check minimum number of eventsNone |
183 |
5. Include endpointsNone |
183 |
6. Filter based on genotype QC (FinnGen only) |
183 |
Control definitions (FinnGen only)
- Control conditions
- not Q17_CLEFT_PALATE_EXCLUDE
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Cleft hard palate NOS
based on the number of shared cases.
Similar with more cases:
- Cleft palate
- Cleft lip, lip and palate or palate
- Congenital malformations, deformations and chromosomal abnormalities
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2587 | 1496 | 1087 |
| Only index persons | 2115 | 1232 | 883 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 4.64 | 4.10 | 5.17 |
| Only index persons | 6.77 | 6.27 | 7.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 183 | 130 | 53 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.02 |
| Median age at first event (years) | 15.18 | 15.92 | 13.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 169
- Matched controls
- 1687
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q35.1
ICD-10 Finland
Cleft hard palate
+∞
235.5
166
*
7490A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS COMPLETA]
+∞
60.0
54
*
74900
ICD-8 Finland
Cleft palate and cleft lip, Cleft palate
+∞
47.1
43
*
4362
FHL
Nozzle reconstruction
547.9
44.4
42
*
4122
FHL
Tympanostomy (tympanic tube)
22.8
36.0
53
33
4364
FHL
Pharyngeal tongue plastic
+∞
31.2
29
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
16.2
31.0
52
45
SJX10
NOMESCO Finland
Short check-up visit for orthodontisk therapy
12.6
30.4
58
67
SBB10
NOMESCO Finland
Teeth copy
10.1
29.8
66
101
Q35.9
ICD-10 Finland
Cleft palate, unspecified
+∞
29.0
27
*
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
333.7
28.7
28
*
SAA04
NOMESCO Finland
Special inverstigation of mouth
13.6
28.1
51
52
7490B
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate[PALATOSCHISIS INCOMPLETA]
+∞
26.8
25
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
16.0
23.1
38
30
Q35.3
ICD-10 Finland
Cleft soft palate
+∞
22.4
21
*
EB1MA
NOMESCO Finland
Cephalometry with X-ray
11.8
22.0
42
46
Q35.71
ICD-10 Finland
Submucous cleft palate
+∞
19.1
18
*
SJC50
NOMESCO Finland
Removal of orthodontisk device with at least 7 brackets
12.9
18.5
33
31
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
8.7
18.2
41
60
H65.3
ICD-10 Finland
Chronic mucoid otitis media
10.4
17.0
34
40
EEC05
NOMESCO Finland
Le Fort I osteotomy
+∞
17.0
16
*
EHC40
NOMESCO Finland
Correction of submucous cleft palate
+∞
17.0
16
*
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
187.8
16.8
17
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
11.9
16.3
30
30
SJD00
NOMESCO Finland
Removal or reattacment of arrow in fixed orthodontisk device
9.1
16.2
35
47
EHC10
NOMESCO Finland
Plastic repair of oronasal or oroantral fistula of palate
+∞
14.8
14
*
4368
FHL
Closing the fistula of the mouth
+∞
14.8
14
*
SJB00
NOMESCO Finland
Fitting of loose orthodontic device with user information
8.8
14.3
31
42
EBB10
NOMESCO Finland
Insertion of dental implant
31.2
13.2
17
6
4361
FHL
Lip plastic or reconstruction due to cleft lip
+∞
12.7
12
*
Q37.0
ICD-10 Finland
Cleft hard palate with bilateral cleft lip
140.0
12.6
13
*
K00.00
ICD-10 Finland
Hypodontia
14.0
12.0
20
16
ENC80
NOMESCO Finland
Plastic operation of soft palate for voice distubance
+∞
11.6
11
*
SAA03
NOMESCO Finland
Extended examination of mouth
3.2
11.5
107
597
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
37.9
11.5
14
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
7.9
11.4
26
38
1450
FHL
Otomicroscopy
27.2
11.4
15
6
SJD30
NOMESCO Finland
Demanding attachment of arrow to fixed orthodontisk device
9.9
11.2
22
25
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prothetic work
19.5
11.0
16
9
K07.25
ICD-10 Finland
Anomalies of dental arch relationship
10.3
10.9
21
23
ZXB10
NOMESCO Finland
Medial
64.2
10.8
12
*
SJD20
NOMESCO Finland
Attachment of modifiable arrow of fixed orthodontisk device
8.0
10.7
24
34
EAB30
NOMESCO Finland
Correction of cleft lip
117.0
10.5
11
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
20.4
10.5
15
8
ZXA10
NOMESCO Finland
Bilateral
4.0
10.2
45
142
SJA01
NOMESCO Finland
Estimation of need for orthodontic care
42.8
10.1
12
*
SJD40
NOMESCO Finland
Fixation of ready made palatinal or lingual arrow
7.2
10.0
24
38
7492A
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS UNILATERALIS COMPLETA]
105.7
9.5
10
*
74920
ICD-8 Finland
Cleft palate and cleft lip, Cheilognathopalatoschisis unilateralis
105.7
9.5
10
*
EHC30
NOMESCO Finland
Reconstruction of palate
+∞
9.5
9
*
SJA03
NOMESCO Finland
Demanding plan for orthodontic care
+∞
9.5
9
*
4451
FHL
Guitar cutting
4.8
9.4
32
78
ECB40
NOMESCO Finland
Surgical treatment of fracture of alveolus
52.8
8.8
10
*
SJA04
NOMESCO Finland
Very demanding plan for orthodontic care
94.6
8.5
9
*
SPF10
NOMESCO Finland
Demanding repatation of teeth prosthesis
47.2
7.8
9
*
EBB15
NOMESCO Finland
Insertion of dental implant abutment
26.4
7.7
10
*
UDC00
NOMESCO Finland
Ear microscopy
4.7
7.5
25
60
SPC10
NOMESCO Finland
Attachment of standard crone of tooth
83.6
7.5
8
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.5
7.5
91
543
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
+∞
7.3
7
*
4365
FHL
Correction of nasal deformity
+∞
7.3
7
*
4141
FHL
Myringoplasty (also for reasons other than inflammation)
+∞
7.3
7
*
SJB60
NOMESCO Finland
External device grinding and adaptation
6.6
7.3
18
30
SJD10
NOMESCO Finland
Attachment of arrow to fixed orthodontisk device
5.3
7.1
21
44
K07.14
ICD-10 Finland
Retrognaty, maxillary
17.6
6.8
10
6
R1260
NOMESCO Finland
Evaluation of communicative skills
23.6
6.7
9
*
J01DA06
ATC
[U] cefuroxime; systemic
3.1
6.6
37
139
ECB17
NOMESCO Finland
Operation for cleft gingiva
72.5
6.5
7
*
EBA10
NOMESCO Finland
Surgical removal of tooth
2.7
6.4
48
216
EB1WA
NOMESCO Finland
NA
18.9
6.3
9
5
EH1JB
NOMESCO Finland
Functional examination of palate
+∞
6.3
6
*
SPB10
NOMESCO Finland
Production of temporary crone to tooth
+∞
6.3
6
*
Q36.9
ICD-10 Finland
Cleft lip, unilateral
+∞
6.3
6
*
Q35
ICD-10 Finland
Cleft palate
+∞
6.3
6
*
7492C
ICD-9 Finland
Cleft palate and cleft lip, Cleft palate with cleft lip[CHEILOPALATOSCHISIS BILATERALIS COMPLETA]
+∞
6.3
6
*
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
8.2
6.3
13
17
UDQ12
NOMESCO Finland
Flexible laryngoscopy
6.5
6.2
15
25
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.3
6.2
31
108
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
8
16
5.18
3.08
1.4
1.7
—
—
—
0
0
36
532
0.60
2.04
2.3
2.4
—
—
—
0
0
35
490
0.65
1.51
2.1
2.2
—
—
—
0
0
15
80
1.95
1.49
6.9
17.3
0.6
1.2
mmol/l
—
9
67
6
24
2.55
1.31
1.0
1.2
—
—
—
0
0
11
56
2.03
1.25
1.1
1.4
—
—
—
0
0
101
1132
0.76
1.04
3.6
3.8
36.6
37.1
mmol/mol
0.24
94
1085
127
1378
0.74
1.02
4.0
4.5
1.8
1.7
mu/l
0.17
120
1299
150
1395
1.42
1.01
8.9
10.2
139.4
139.5
mmol/l
0.20
145
1347
150
1400
1.40
0.95
9.0
10.2
3.9
3.9
mmol/l
0.05
143
1346
118
1285
0.77
0.90
3.1
3.2
5.6
5.6
mmol/l
0.16
110
1200
8
43
1.90
0.88
11.8
15.9
0.7
0.7
%
—
8
43
11
64
1.76
0.88
1.6
1.5
—
—
—
0
0
8
44
1.85
0.87
11.8
15.6
1.0
1.5
%
—
8
44
126
1357
0.77
0.84
3.3
3.3
3.0
2.8
mmol/l
2.18
114
1289
82
718
1.26
0.78
4.3
4.5
0.0
0.0
estimate
0.00
12
150
5
24
2.11
0.75
2.2
1.5
13.0
13.3
%
—
5
24
83
731
1.25
0.75
2.9
3.2
0.0
0.0
estimate
0.00
12
143
46
377
1.29
0.74
1.5
1.5
—
—
—
0
0
9
56
1.64
0.73
1.0
1.3
—
—
—
0
0
7
40
1.78
0.72
1.0
1.1
—
—
—
0
0
10
61
1.68
0.70
1.0
1.2
—
—
—
0
0
80
707
1.23
0.69
3.6
4.2
—
—
—
0
0
51
430
1.26
0.66
2.6
3.2
—
—
—
0
0
81
720
1.22
0.65
2.9
3.2
0.0
0.0
estimate
0.00
12
144
13
87
1.53
0.65
8.5
13.4
25.0
24.8
mmol/l
0.10
13
87
13
187
0.67
0.65
1.8
1.7
—
—
—
0
0
18
242
0.72
0.63
1.1
1.3
25.5
11.1
u/ml
—
10
100
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
127
1346
0.82
0.58
2.9
3.1
1.4
1.5
mmol/l
0.84
116
1284
120
1278
0.82
0.57
2.8
2.9
1.3
1.2
mmol/l
0.79
109
1215
19
248
0.74
0.56
1.2
1.8
—
—
—
0
0
9
60
1.53
0.55
1.1
1.1
—
11.8
—
0
10
12
169
0.69
0.55
1.5
1.5
—
—
—
0
0
52
452
1.21
0.51
3.9
5.7
36.1
37.3
g/l
0.77
47
430
24
298
0.78
0.50
1.5
1.5
—
—
—
0
0
8
116
0.68
0.47
1.4
1.5
—
—
—
0
0
40
462
0.83
0.45
1.2
1.4
0.6
2.4
u/ml
—
9
108
129
1351
0.85
0.43
3.0
3.2
4.8
4.7
mmol/l
1.35
117
1292
80
733
1.16
0.42
4.1
5.6
6.2
6.3
mmol/l
0.08
72
640
20
248
0.78
0.42
1.1
1.3
34.8
16.6
iu/ml
—
5
74
0
15
0.00
0.41
0.0
2.2
—
55.5
—
0
9
0
17
0.00
0.41
0.0
6.4
—
99.3
—
0
17
79
854
0.87
0.39
9.2
8.8
4.1
4.0
e9/l
0.16
69
753
110
1162
0.87
0.39
3.5
4.0
13.9
14.4
pmol/l
1.67
102
1075
5
36
1.40
0.38
1.0
1.2
—
—
—
0
0
8
114
0.69
0.38
1.4
1.5
297.5
336.0
mu/l
—
8
104
39
343
1.17
0.34
3.4
2.4
42.5
37.9
ng/l
0.07
18
143
27
315
0.83
0.34
1.3
1.9
—
—
—
0
0
39
345
1.17
0.32
2.6
2.9
0.4
0.3
e6/l
0.40
30
249
10
131
0.75
0.32
1.0
1.0
—
—
—
0
0
10
131
0.75
0.32
2.2
1.7
—
—
—
0
0
97
1025
0.89
0.32
4.2
3.6
10.8
8.4
mm/h
0.81
91
953
21
176
1.22
0.30
3.5
3.5
1080.5
664.7
ng/l
0.46
15
142
8
107
0.74
0.30
2.6
3.3
4.8
4.9
pmol/l
—
8
97
92
972
0.89
0.29
7.0
6.1
81.3
77.6
u/l
0.29
85
910
13
103
1.28
0.29
3.3
5.4
—
—
—
0
0
9
119
0.74
0.28
1.6
1.4
—
—
—
0
0
12
150
0.79
0.28
1.5
1.5
—
—
—
0
0
12
150
0.79
0.28
1.5
1.5
—
—
—
0
0
12
150
0.79
0.28
1.5
1.5
—
—
—
0
0
12
150
0.79
0.28
1.5
1.5
—
—
—
0
0
17
203
0.82
0.27
1.2
1.4
—
—
—
0
0
11
86
1.30
0.27
2.5
3.1
14.4
20.4
%
—
5
30
5
71
0.70
0.26
2.8
2.0
—
89.6
—
0
27
37
333
1.14
0.25
1.9
2.0
—
—
—
0
0
27
305
0.87
0.24
1.6
2.0
198.6
404.6
u/l
0.45
22
293
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
10
0.00
0.21
0.0
1.0
—
147.5
—
0
10
0
10
0.00
0.21
0.0
3.7
—
12.9
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
11
134
0.81
0.21
2.3
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
56
525
1.10
0.19
6.8
8.4
1.2
1.2
mmol/l
0.06
51
455
16
185
0.85
0.19
1.4
2.4
2355.0
3737.8
u/l
—
7
83
23
205
1.14
0.18
2.7
3.0
1.0
0.7
e6/l
—
10
112
7
62
1.13
0.17
1.3
1.4
—
—
—
0
0
10
120
0.82
0.17
1.6
1.5
—
—
—
0
0
29
317
0.90
0.16
2.2
2.3
1.1
1.0
mg/l
0.08
20
229
15
172
0.86
0.16
2.3
2.4
14.0
14.2
umol/l
0.03
15
160
8
71
1.13
0.16
1.1
1.5
—
—
—
0
0
22
197
1.13
0.16
2.7
3.1
4.6
2.3
e6/l
—
10
103
11
93
1.19
0.15
3.6
2.0
10.9
13.1
nmol/l
0.32
11
84
152
1495
1.10
0.14
11.2
11.8
39.5
40.4
%
0.79
126
1265
8
97
0.82
0.14
2.0
2.1
—
—
—
0
0
153
1506
1.10
0.14
10.1
10.2
23.2
20.8
mg/l
0.32
120
1143
12
138
0.86
0.13
1.7
1.6
—
—
—
0
0
55
569
0.95
0.08
2.9
2.6
69.2
72.1
nmol/l
0.30
49
524
8
75
1.07
0.07
1.5
1.3
—
—
—
0
0
58
563
1.04
0.07
2.8
3.1
—
—
—
0
0
10
110
0.90
0.05
1.4
1.5
11.6
17.2
iu/l
—
10
89
37
383
0.96
0.05
2.8
3.2
0.0
0.0
estimate
0.50
12
150
128
1270
1.03
0.02
7.7
7.7
100.0
97.7
ml/min/173m2
0.51
99
996
156
1551
1.04
0.02
8.3
8.0
26.0
25.7
u/l
0.08
148
1502
13
138
0.94
0.02
2.4
2.5
21.2
24.2
%
0.46
13
120
54
547
0.98
0.01
1.6
1.8
—
—
—
0
0
19
194
0.98
0.00
2.3
3.0
1072.9
295.4
ng/l
—
9
107
12
121
0.99
0.00
1.1
1.3
—
—
—
0
0
23
234
0.98
0.00
3.6
4.0
10.1
14.0
mg/mmol
0.22
16
154
19
189
1.01
0.00
1.8
1.5
—
—
—
0
0
38
384
0.99
0.00
2.6
3.1
2.4
2.4
mmol/l
0.04
31
347
48
477
1.01
0.00
7.2
8.2
1.2
1.2
mmol/l
0.09
41
440
143
1435
0.98
0.00
4.0
4.1
—
—
—
0
0
11
115
0.95
0.00
2.7
3.0
1.5
1.5
ug/l
0.00
11
104
5
55
0.91
0.00
1.2
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
6
59
1.02
0.00
1.7
4.9
140.2
159.0
%
—
6
59
0
5
0.00
0.00
0.0
1.6
—
213.2
—
0
5
0
7
0.00
0.00
0.0
1.6
—
714.0
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
3.3
—
49.7
—
0
7
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
5
50
1.00
0.00
2.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
125.0
—
0
5
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
10.9
—
0
9
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
10
100
1.00
0.00
2.0
2.7
—
—
—
0
0
6
60
1.00
0.00
1.3
1.7
—
—
—
0
0
40
400
1.00
0.00
1.5
1.7
91.1
97.8
pmol/l
0.62
23
211
0
5
0.00
0.00
0.0
6.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
102.5
—
0
8
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
0.00
1.5
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CLEFT_HARD_PALATE_NOS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have Q17_CLEFT_HARD_PALATE_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: Q17_CLEFT_HARD_PALATE_NOS – Cleft hard palate NOS
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data