No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
166 |
4. Check minimum number of eventsNone |
166 |
5. Include endpointsNone |
166 |
6. Filter based on genotype QC (FinnGen only) |
155 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E20-E35
- Name in latin
- Perturbationes adrenogenitales
Similar endpoints
↥List of similar endpoints to
Adrenogenital disorders
based on the number of shared cases.
Similar with more cases:
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1321 | 789 | 518 |
| Only index persons | 1074 | 671 | 403 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 53.68 | 48.68 | 61.35 |
| Only index persons | 49.85 | 44.47 | 58.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 155 | 95 | 60 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 52.02 | 47.17 | 59.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 166
- Matched controls
- 1660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E25.9
ICD-10 Finland
Adrenogenital disorder, unspecified
+∞
76.0
67
*
E25.01
ICD-10 Finland
Congenital adrenal hyperplasia
+∞
50.7
46
*
E25.00
ICD-10 Finland
Congenital salt-losing adrenal hyperplasia
+∞
47.2
43
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
31.2
29
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
11.5
31.2
36
39
E25.8
ICD-10 Finland
Other adrenogenital disorders
+∞
25.7
24
*
H02AB09
ATC
hydrocortisone; systemic
28.9
23.2
31
13
H02AA02
ATC
fludrocortisone; oral
50.3
18.8
22
5
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
31.4
17.0
22
8
A11CC03
ATC
alfacalcidol; systemic
31.4
17.0
22
8
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
15.9
15
*
E25.0
ICD-10 Finland
Congenital adrenogenital disorders associated with enzyme deficiency
+∞
15.9
15
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.9
15.7
41
104
A12AA04
ATC
calcium carbonate; oral
40.1
14.8
18
5
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
4.6
13.8
38
100
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.6
12.1
25
51
25502
ICD-8 Finland
Diseases of adrenal glands, Virilismus adrenocorticalis
+∞
11.6
11
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
11.6
11
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.3
11.1
56
222
ZXE20
NOMESCO Finland
More than three and less than five hours
3.9
10.6
37
115
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
3.2
10.0
49
190
ZXE10
NOMESCO Finland
More than one and less than three hours
2.9
10.0
78
393
2552A
ICD-9 Finland
Disorders of adrenal glands, Adrenogenital disorders[SYNDROMA ADRENOGENITALE CONGENITUM]
+∞
9.5
9
*
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
4.7
9.3
23
55
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
5.0
9.1
21
47
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
17.5
8.7
13
8
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.7
8.6
72
369
E66.01
ICD-10 Finland
Obesity due to excess calories
4.0
8.5
26
73
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
8.1
62
303
TK800
NOMESCO Finland
Hemodialysis
16.0
7.8
12
8
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
7.7
56
266
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
26.4
7.7
10
*
C08CA02
ATC
felodipine; oral
3.7
7.6
26
79
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
7.4
7.5
17
25
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.6
7.5
27
85
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
83.7
7.5
8
*
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
83.7
7.5
8
*
C01DA14
ATC
isosorbide mononitrate; oral
3.0
7.5
40
161
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.9
7.4
23
65
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
4.7
7.4
18
42
C03CA01
ATC
furosemide; systemic
2.5
7.3
69
369
321
Kela drug reimbursment
Paricalcitol and cinacalcet
+∞
7.3
7
*
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
3.7
7.1
24
72
ZXD10
NOMESCO Finland
Scheduled procedure
2.4
7.1
75
422
N03AX16
ATC
[U] pregabalin
2.7
7.0
48
220
C07AB02
ATC
metoprolol; systemic
2.7
7.0
48
220
N18.8
ICD-10 Finland
Other chronic renal failure
10.0
6.9
13
14
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.6
6.8
49
229
V03AE01
ATC
polystyrene sulfonate; oral
17.6
6.8
10
6
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
6.8
44
195
Z49.1
ICD-10 Finland
Extracorporeal dialysis
23.6
6.7
9
*
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
4.3
6.6
18
46
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
6.5
42
186
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
72.5
6.5
7
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.6
6.4
44
201
196
Kela drug reimbursment
Paricalcitol and cinacalcet
+∞
6.3
6
*
E27.0
ICD-10 Finland
Other adrenocortical overactivity
+∞
6.3
6
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
6.3
34
137
C10AA01
ATC
simvastatin; oral
2.3
6.3
75
440
I21.99
ICD-10 Finland
Myocardial infarction (acute) UNS unspecified coronary artery status
8.2
6.3
13
17
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
6.2
29
107
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
21
0
+∞
22.39
8.3
0.0
68.76
—
nmol/l
—
21
0
34
63
6.53
18.48
6.6
2.0
8.71
13.62
nmol/l
2.03
34
63
36
89
4.89
14.14
7.0
3.2
162.04
71.26
ng/l
2.04
28
77
108
596
3.32
12.46
15.8
6.2
1.23
1.21
mmol/l
0.60
87
506
18
33
5.99
6.84
2.6
1.2
7.63
6.97
u/l
0.07
11
28
21
67
3.44
5.69
1.9
1.7
—
—
—
0
0
32
132
2.76
5.64
2.3
1.8
—
—
—
0
0
74
453
2.14
5.37
5.4
3.2
—
—
—
0
0
42
204
2.42
5.30
2.6
1.9
—
—
—
0
0
46
233
2.35
5.28
1.8
1.7
1056.17
1170.77
nmol/l
0.27
41
168
31
131
2.68
5.20
2.3
1.7
—
—
—
0
0
60
357
2.07
4.55
5.2
2.9
0.26
0.51
e6/l
0.69
48
256
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
10
21
5.00
3.62
2.7
2.5
0.27
0.40
u/ml
—
5
12
23
104
2.41
3.34
3.2
2.8
24.72
29.52
u/l
0.72
18
90
11
29
3.99
3.25
1.5
2.1
—
—
—
0
0
51
321
1.85
3.13
5.5
3.8
25.30
10.66
mg/mmol
0.94
38
206
95
725
1.73
2.96
7.7
4.1
7.13
6.54
mmol/l
1.43
90
668
67
475
1.69
2.67
2.6
2.0
90.85
94.70
pmol/l
0.30
38
239
5
7
7.32
2.56
4.4
5.4
—
—
—
0
0
31
177
1.92
2.53
2.0
2.0
29.58
29.61
s
0.01
31
171
10
32
3.26
2.48
1.2
1.5
—
—
—
0
0
73
546
1.60
2.28
22.8
13.9
1.22
1.27
inr
0.18
25
161
36
224
1.78
2.24
6.2
3.2
36.83
107.14
ng/l
1.04
29
171
93
745
1.56
2.11
12.0
9.4
4.17
4.13
e9/l
0.07
80
650
84
662
1.54
2.03
7.0
5.8
9.85
10.77
umol/l
0.69
84
622
5
11
4.65
1.95
1.0
1.3
—
—
—
0
0
7
22
3.27
1.90
1.6
1.5
—
—
—
0
0
40
269
1.64
1.88
1.8
1.8
0.85
1.45
mg/l
0.89
32
209
6
17
3.62
1.85
1.7
1.4
—
—
—
0
0
6
17
3.62
1.85
1.7
1.5
—
—
—
0
0
7
23
3.13
1.82
2.3
2.8
61.57
59.48
%
—
7
23
7
23
3.13
1.82
1.4
1.5
—
—
—
0
0
11
47
2.44
1.82
6.5
3.0
—
—
—
0
0
6
19
3.24
1.67
1.0
1.1
—
—
—
0
0
11
49
2.33
1.67
15.5
7.7
24.30
23.88
mmol/l
0.17
11
49
6
22
2.79
1.45
1.7
1.2
—
—
—
0
0
21
128
1.73
1.41
5.5
3.4
—
—
—
0
0
31
210
1.59
1.41
4.5
2.7
0.94
0.85
e6/l
0.06
14
107
7
29
2.47
1.41
1.9
1.2
—
19.30
—
0
5
0
40
0.00
1.34
0.0
1.5
—
—
—
0
0
14
76
1.92
1.34
2.1
1.2
—
—
—
0
0
30
205
1.57
1.32
4.6
3.0
5.09
3.33
e6/l
0.29
13
104
57
446
1.42
1.30
6.5
3.4
2.33
2.36
mmol/l
0.74
52
387
5
18
2.83
1.29
1.2
1.4
—
—
—
0
0
106
930
1.39
1.20
5.4
3.9
15.28
11.71
mm/h
1.42
101
832
16
96
1.74
1.15
8.6
5.0
5.13
5.06
kpa
0.18
16
91
15
91
1.71
1.04
2.2
1.6
—
—
—
0
0
5
23
2.21
0.98
1.8
1.2
—
—
—
0
0
12
72
1.72
0.88
1.0
1.0
—
—
—
0
0
6
31
1.97
0.85
2.0
1.3
—
—
—
0
0
6
31
1.97
0.85
2.2
1.6
—
—
—
0
0
6
33
1.85
0.80
2.2
1.6
—
—
—
0
0
0
25
0.00
0.79
0.0
1.1
—
—
—
0
0
27
204
1.39
0.75
1.4
1.3
31.88
38.72
iu/ml
—
6
59
5
24
2.12
0.75
1.6
1.4
—
—
—
0
0
5
24
2.12
0.75
1.6
1.4
—
—
—
0
0
11
168
0.63
0.72
1.6
2.3
—
—
—
0
0
125
1169
1.28
0.66
23.2
12.8
76.40
82.91
ml/min/173m2
1.53
108
937
25
192
1.36
0.64
1.2
1.3
1.30
10.90
u/ml
—
9
71
20
149
1.39
0.61
11.1
5.2
104.70
103.74
mmol/l
0.35
20
149
72
640
1.22
0.59
6.3
5.2
0.00
0.00
estimate
-0.00
21
119
12
81
1.52
0.59
1.9
2.4
76.29
66.90
ml/min/173m2
—
7
30
6
37
1.64
0.56
3.0
2.0
—
—
—
0
0
13
180
0.70
0.55
1.7
2.4
—
—
—
0
0
52
452
1.22
0.52
6.8
3.9
37.34
48.38
ng/l
0.41
41
310
41
348
1.24
0.51
3.9
4.3
0.00
0.00
estimate
-0.00
20
114
105
979
1.20
0.49
5.0
3.9
14.95
14.81
pmol/l
0.26
100
866
5
31
1.63
0.43
1.4
1.3
—
—
—
0
0
8
56
1.45
0.43
3.0
2.4
—
—
—
0
0
11
79
1.42
0.42
1.3
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
2.88
—
0
8
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
2.0
—
—
—
0
0
0
17
0.00
0.41
0.0
2.0
—
—
—
0
0
0
17
0.00
0.41
0.0
2.0
—
—
—
0
0
5
35
1.44
0.39
1.6
1.3
—
—
—
0
0
13
98
1.35
0.39
1.3
2.0
—
—
—
0
0
92
861
1.15
0.37
3.5
3.3
—
—
—
0
0
70
643
1.15
0.36
4.6
3.9
0.00
0.01
estimate
0.50
23
128
89
832
1.15
0.36
3.6
3.0
45.50
43.55
u/l
0.15
82
776
32
276
1.20
0.35
1.7
1.7
—
—
—
0
0
70
647
1.14
0.33
4.5
3.9
0.00
0.00
estimate
-0.00
22
112
7
52
1.36
0.31
3.4
2.1
—
—
—
0
0
12
147
0.80
0.24
13.3
7.4
—
—
—
0
0
5
38
1.33
0.23
1.6
1.2
—
—
—
0
0
35
317
1.13
0.22
1.5
1.3
1.39
1.37
u/ml
—
8
78
8
103
0.77
0.22
1.6
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
10.09
—
0
11
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.7
—
13.61
—
0
13
0
13
0.00
0.21
0.0
1.2
—
1.20
—
0
5
124
1205
1.11
0.20
5.1
4.2
4.40
4.63
mmol/l
1.70
119
1110
6
48
1.26
0.20
1.3
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
203.86
—
0
14
6
50
1.21
0.20
1.0
1.6
—
—
—
0
0
131
1279
1.11
0.19
26.9
13.8
24.29
23.93
mg/l
0.04
112
1012
126
1234
1.09
0.14
5.7
4.7
2.58
2.75
mmol/l
1.19
121
1121
52
495
1.07
0.12
4.9
4.0
—
—
—
0
0
5
44
1.14
0.10
1.0
1.2
—
—
—
0
0
5
44
1.14
0.10
1.4
1.4
—
—
—
0
0
5
45
1.11
0.10
1.0
1.2
—
—
—
0
0
5
47
1.07
0.09
3.6
1.5
2.53
3.27
mg/l
—
5
32
122
1200
1.06
0.09
5.1
4.1
1.44
1.48
mmol/l
0.43
116
1094
31
294
1.07
0.08
3.3
2.1
—
—
—
0
0
24
227
1.07
0.06
3.1
4.5
26.99
21.08
%
0.71
12
117
59
575
1.04
0.05
3.7
2.4
—
—
—
0
0
31
298
1.05
0.05
3.6
4.9
1.84
2.35
ug/l
0.59
26
258
21
201
1.05
0.03
1.8
1.4
—
—
—
0
0
116
1151
1.03
0.02
4.7
3.8
1.44
1.24
mmol/l
2.26
110
1047
142
1424
0.98
0.00
37.7
19.8
39.76
39.98
%
0.15
134
1342
15
151
0.99
0.00
5.9
4.5
35.93
31.15
%
1.18
15
92
119
1188
1.01
0.00
6.5
4.3
6.01
5.83
mmol/l
0.58
114
1070
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
100.44
—
0
9
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
70
1.00
-0.00
1.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
38.50
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_ADRENOGEN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ADRENOGEN | 2.292 [1.79, 2.93] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.259 |
During the follow-up period (1.1.1998 — 31.12.2019), 185 out of 572 females with E4_ADRENOGEN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ADRENOGEN | 2.783 [1.92, 4.04] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 182 out of 401 males with E4_ADRENOGEN died.
Mortality risk
Mortality risk for people of age
years, who have E4_ADRENOGEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.204% | 0.453% |
| 5 | 1.287% | 2.978% |
| 10 | 3.461% | 7.181% |
| 15 | 6.431% | 13.75% |
| 20 | 11.168% | 22.495% |
Relationships between endpoints
↥Index endpoint: E4_ADRENOGEN – Adrenogenital disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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