hypothyroidism: Abnormally low levels of thyroid hormone.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
204 |
4. Check minimum number of eventsNone |
204 |
5. Include endpointsNone |
204 |
6. Filter based on genotype QC (FinnGen only) |
204 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E03
- Name in latin
- Hypothyreosis postinfectiosa
Similar endpoints
↥List of similar endpoints to
Postinfectious hypothyroidism
based on the number of shared cases.
Similar with more cases:
- Hypothyroidism (congenital or acquired)
- Hypothyreosis and Thyroxine purchase for inclusion criteria
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2062 | 1681 | 349 |
| Only index persons | 1434 | 1198 | 236 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.01 |
| Only index persons | 0.04 | 0.04 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 55.61 | 56.08 | 52.28 |
| Only index persons | 48.62 | 49.33 | 45.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 204 | 170 | 34 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.01 |
| Median age at first event (years) | 41.32 | 40.35 | 46.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 193
- Matched controls
- 1930
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
2237.1
231.1
184
17
104
Kela drug reimbursment
Thyroid insufficiency
2682.3
178.5
145
*
2448A
ICD-9 Finland
Acquired hypothyroidism, Other specified acquired hypothyroidism[HYPOTHYREOSIS POST THYREOIDITIDEM]
+∞
165.3
134
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1389.0
135.1
116
*
E03.3
ICD-10 Finland
Postinfectious hypothyroidism
+∞
69.0
62
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
511.5
42.9
41
*
E03
ICD-10 Finland
Other hypothyroidism
146.5
35.0
36
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
399.5
34.0
33
*
A10AA02
ATC
NA
20.9
26.2
39
23
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
32.8
25.5
33
12
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
19.6
24.4
37
23
A10AA01
ATC
NA
24.0
24.0
34
17
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
10.2
23.6
49
62
A10AE04
ATC
insulin glargine; parenteral
9.8
22.6
48
63
T86
ICPC
Hypothyroidism/myxoedema
246.8
22.1
22
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
14.5
21.7
37
31
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
10.5
21.4
43
51
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
21.9
20.7
30
16
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
16.3
20.5
33
24
T89
ICPC
Diabetes insulin dependent
14.5
18.4
31
25
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
18.0
17
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
23.7
17.8
25
12
103
Kela drug reimbursment
Diabetes, insulin-treated
4.4
17.5
78
259
H04AA01
ATC
glucagon; nasal, parenteral
25.9
16.9
23
10
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.4
16.4
71
227
A10AE05
ATC
insulin detemir; parenteral
11.2
15.9
30
31
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
19.4
14.2
21
12
E03.8
ICD-10 Finland
Other specified hypothyroidism
+∞
13.7
13
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
13.6
13.0
22
18
E10
ICD-10 Finland
Type 1 diabetes mellitus
17.9
11.9
18
11
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
46.1
11.1
13
*
K29.4
ICD-10 Finland
Chronic atrophic gastritis
23.1
10.9
15
7
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
116.1
10.5
11
*
XCK10
NOMESCO Finland
Photography of fundus of eye
4.6
10.0
36
92
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
58.0
9.7
11
*
SPAT1262
SPAT
Handing over of treatment supplies
3.6
9.5
46
155
H3603, E103
ICD-10 Finland
NA
38.7
9.1
11
*
A12AA04
ATC
calcium carbonate; oral
52.4
8.8
10
*
A11CC03
ATC
alfacalcidol; systemic
35.0
8.2
10
*
4019X
ICD-9 Finland
Essential hypertension, Unspecified
8.0
7.9
17
23
A10AA03
ATC
NA
19.3
7.7
11
6
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
19.3
7.7
11
6
B03BA03
ATC
hydroxocobalamin; parenteral
6.1
7.6
20
36
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
7.5
67
330
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
+∞
7.3
7
*
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
+∞
7.3
7
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
21.0
7.2
10
5
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
12.7
7.2
12
10
E66.01
ICD-10 Finland
Obesity due to excess calories
4.7
7.0
23
54
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
7.2
7.0
16
24
107
Kela drug reimbursment
Pernicious anaemia
11.5
6.9
12
11
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
17.5
6.8
10
6
H3601, E113
ICD-10 Finland
NA
41.6
6.8
8
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
41.6
6.8
8
*
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
41.6
6.8
8
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
23.5
6.7
9
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
6.6
43
174
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.2
6.4
35
125
E06.3
ICD-10 Finland
Autoimmune thyroiditis
+∞
6.3
6
*
E03.1
ICD-10 Finland
Congenital hypothyroidism without goitre
+∞
6.3
6
*
H3600, E103
ICD-10 Finland
NA
27.7
6.3
8
*
A10AE06
ATC
insulin degludec; parenteral
7.1
6.2
14
21
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
7.1
6.2
14
21
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.4
6.1
60
308
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.6
6.1
47
212
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
178
1250
4.33
12.47
10.1
2.6
16.5
14.5
pmol/l
14.28
168
1142
26
66
4.37
9.66
4.2
4.2
1.3
1.7
mmol/l
0.23
19
53
116
787
2.10
6.25
11.2
5.6
1.2
1.2
mmol/l
1.30
95
672
98
628
2.08
6.12
2.0
1.9
109.2
96.1
pmol/l
1.19
48
302
132
953
2.09
5.86
6.9
3.8
7.9
6.6
mmol/l
4.68
122
894
54
284
2.23
5.53
1.7
1.7
1341.1
1271.4
nmol/l
0.10
49
215
104
701
1.99
5.46
9.9
4.7
1.2
1.2
mmol/l
0.99
93
646
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
12
28
4.49
4.89
2.7
2.9
0.2
0.3
u/ml
—
6
17
101
695
1.90
4.80
3.0
2.2
73.8
77.4
nmol/l
0.70
93
631
127
954
1.88
4.48
9.1
9.2
4.2
4.2
e9/l
0.00
116
840
59
347
1.99
4.42
1.9
1.7
2005.6
465.9
pmol/l
0.49
49
296
179
1534
2.36
4.08
11.8
3.5
1.7
1.9
mu/l
0.20
168
1404
157
1283
1.97
4.05
9.4
6.9
82.9
77.5
u/l
0.55
151
1203
60
365
1.91
4.03
1.7
1.5
17.9
22.0
nmol/l
1.93
53
317
84
575
1.78
3.85
4.6
2.8
—
—
—
0
0
74
492
1.79
3.71
2.4
2.0
100.5
198.7
u/l
1.76
69
461
113
850
1.74
3.67
4.4
3.9
0.0
0.0
estimate
0.50
20
153
92
657
1.73
3.57
4.5
4.1
—
—
—
0
0
110
839
1.68
3.26
6.0
5.4
0.0
0.0
estimate
0.40
21
161
109
833
1.66
3.17
4.1
4.0
0.0
0.0
estimate
0.00
21
162
33
178
2.02
3.09
5.8
4.4
36.0
32.4
%
0.97
25
111
56
360
1.77
3.08
1.4
1.2
0.9
2.1
u/ml
—
6
101
87
632
1.66
3.06
3.7
3.7
51.0
31.1
ng/l
0.45
56
425
22
102
2.30
2.99
2.1
1.5
—
—
—
0
0
8
17
4.85
2.95
1.6
1.1
—
—
—
0
0
11
37
3.09
2.73
1.0
1.1
—
3.0
—
0
8
92
696
1.59
2.65
7.0
3.5
34.8
35.8
g/l
0.89
86
651
11
38
3.00
2.62
6.9
2.2
—
—
—
0
0
39
236
1.81
2.60
2.4
1.8
—
—
—
0
0
147
1253
1.62
2.45
6.8
4.2
13.2
11.6
mm/h
0.86
133
1157
10
35
2.95
2.34
5.3
2.2
24.3
25.9
mmol/l
—
10
27
7
18
3.99
2.27
1.1
1.1
—
—
—
0
0
6
163
0.35
2.12
1.3
1.7
—
—
—
0
0
49
335
1.61
2.09
1.6
1.3
24.9
32.6
iu/ml
0.24
17
112
55
387
1.58
2.09
1.7
1.6
0.9
1.1
mg/l
0.57
41
310
6
15
4.09
2.05
1.7
1.3
—
—
—
0
0
20
106
1.98
1.99
8.7
3.0
149.7
78.3
ng/l
0.84
15
97
93
740
1.47
1.97
4.3
2.6
69.0
87.6
ug/l
1.66
88
682
9
33
2.81
1.95
1.4
1.7
—
—
—
0
0
44
298
1.61
1.95
1.5
1.5
—
—
—
0
0
9
35
2.64
1.82
1.2
1.5
—
—
—
0
0
13
60
2.25
1.82
2.9
1.9
—
—
—
0
0
183
1692
1.79
1.77
25.8
14.7
139.0
139.7
mmol/l
2.69
177
1647
46
323
1.55
1.75
1.5
1.3
4.7
10.2
u/ml
0.73
19
127
38
256
1.60
1.72
4.1
2.6
2.1
1.2
e6/l
0.32
24
139
182
1683
1.75
1.72
22.3
13.2
21.8
22.4
mg/l
0.08
158
1313
51
368
1.51
1.71
4.5
4.2
1.0
1.0
kg/l
0.32
12
55
61
457
1.48
1.71
4.0
2.8
0.6
0.4
e6/l
0.31
49
334
16
83
2.01
1.70
2.4
1.7
—
—
—
0
0
10
43
2.39
1.63
1.0
1.3
—
—
—
0
0
6
20
3.06
1.59
1.3
1.2
—
—
—
0
0
60
456
1.45
1.55
4.8
4.2
0.0
0.0
estimate
0.50
20
166
5
15
3.39
1.53
1.0
1.5
—
—
—
0
0
6
21
2.91
1.51
1.2
1.2
—
—
—
0
0
6
21
2.91
1.51
1.2
1.2
—
—
—
0
0
6
21
2.91
1.51
1.2
1.2
—
—
—
0
0
6
21
2.91
1.51
1.2
1.2
—
—
—
0
0
6
21
2.91
1.51
1.2
1.2
—
—
—
0
0
182
1695
1.68
1.51
26.0
14.6
4.0
4.0
mmol/l
0.95
176
1643
6
22
2.78
1.44
1.0
1.5
—
—
—
0
0
16
89
1.87
1.42
7.6
4.4
26.0
25.1
mmol/l
0.39
16
89
9
41
2.25
1.39
1.0
1.2
—
—
—
0
0
28
187
1.58
1.33
11.0
5.8
104.4
103.8
mmol/l
0.28
28
182
58
451
1.40
1.31
1.8
1.6
1.5
1.4
mmol/l
0.34
50
382
8
34
2.41
1.30
1.4
1.4
—
—
—
0
0
8
35
2.34
1.28
1.6
1.4
—
—
—
0
0
25
164
1.60
1.28
2.2
1.8
—
—
—
0
0
52
399
1.41
1.26
2.5
2.2
—
—
—
0
0
92
776
1.34
1.24
4.6
3.7
—
—
—
0
0
8
37
2.21
1.23
1.3
1.2
—
—
—
0
0
58
458
1.37
1.19
2.9
2.9
1971.8
1171.1
ng/l
0.43
48
390
39
287
1.44
1.19
6.1
3.4
548.7
186.7
ng/l
0.39
30
205
70
571
1.34
1.17
2.7
3.1
2.3
2.4
mmol/l
0.89
62
502
33
236
1.48
1.16
4.0
2.8
2.5
3.3
e6/l
0.26
18
120
51
396
1.38
1.16
2.5
2.2
344.0
6540.4
umol/l
2.03
39
347
11
58
1.95
1.14
3.0
1.8
—
—
—
0
0
20
128
1.62
1.13
4.7
3.6
1.2
1.2
mmol/l
0.74
15
117
24
161
1.56
1.13
2.1
1.8
—
—
—
0
0
16
97
1.70
1.10
1.3
1.2
128.1
112.3
iu/ml
—
9
34
8
41
1.99
1.10
1.4
1.3
265.5
282.8
mu/l
—
8
35
5
21
2.41
1.09
1.6
1.3
—
—
—
0
0
5
21
2.41
1.09
1.2
1.2
—
—
—
0
0
5
21
2.41
1.09
1.2
1.5
—
—
—
0
0
11
59
1.91
1.09
1.5
1.2
—
—
—
0
0
7
32
2.23
1.09
1.1
1.4
—
—
—
0
0
9
46
2.00
1.05
1.0
2.7
—
4.1
—
0
5
5
23
2.20
0.98
1.8
1.4
—
—
—
0
0
9
51
1.80
0.96
1.2
1.1
—
—
—
0
0
7
37
1.92
0.95
1.0
1.3
—
—
—
0
0
166
1556
1.36
0.92
20.3
12.1
74.5
81.0
ml/min/173m2
2.69
139
1268
6
29
2.10
0.90
1.2
1.5
—
—
—
0
0
14
89
1.62
0.83
4.5
2.5
1.4
1.1
%
0.71
14
89
8
46
1.77
0.83
3.5
4.3
11.4
33.9
mg/l
—
8
30
164
1546
1.31
0.78
9.5
5.5
46.5
39.3
mmol/mol
7.67
153
1451
5
24
2.11
0.75
1.4
1.1
—
—
—
0
0
7
42
1.69
0.69
1.0
1.4
—
2.6
—
0
11
117
1070
1.22
0.69
3.6
3.2
—
—
—
0
0
5
28
1.80
0.66
1.8
1.3
—
—
—
0
0
5
28
1.80
0.66
1.8
1.3
—
—
—
0
0
5
29
1.74
0.64
1.6
1.3
—
—
—
0
0
21
157
1.38
0.62
1.3
1.9
—
—
—
0
0
14
97
1.48
0.61
12.4
6.7
93.4
94.1
%
0.18
14
97
21
159
1.36
0.58
2.0
3.2
—
—
—
0
0
8
55
1.47
0.57
1.5
1.9
—
—
—
0
0
22
170
1.33
0.54
1.3
2.0
—
—
—
0
0
6
99
0.59
0.53
1.0
1.6
—
—
—
0
0
6
40
1.51
0.52
1.3
1.2
—
—
—
0
0
13
93
1.42
0.49
14.4
7.8
23.0
24.8
mmol/l
0.70
13
87
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
12
90
1.35
0.36
1.7
1.5
—
—
—
0
0
182
1778
1.22
0.33
15.6
9.8
26.0
24.8
u/l
0.43
176
1723
7
53
1.33
0.31
1.3
1.3
—
—
—
0
0
8
108
0.73
0.30
3.1
2.6
0.5
0.9
ug/l
—
8
60
5
72
0.69
0.26
1.6
1.5
—
—
—
0
0
35
314
1.14
0.24
2.5
2.5
2.4
2.5
mmol/l
0.27
29
271
12
147
0.80
0.24
6.1
4.6
21.4
21.8
%
—
7
71
5
38
1.32
0.23
1.0
1.2
—
47.1
—
0
6
136
1402
0.91
0.22
27.1
16.0
13.8
13.7
%
0.80
130
1382
5
42
1.20
0.21
1.8
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
46.9
—
0
11
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
51
1.18
0.19
1.3
1.7
—
—
—
0
0
116
1125
1.07
0.16
4.3
2.7
71.9
41.9
u/l
1.50
108
1062
162
1648
0.92
0.15
6.3
4.1
1.6
1.6
mmol/l
0.11
148
1524
7
86
0.81
0.15
1.0
1.0
—
—
—
0
0
149
1519
0.93
0.14
25.0
13.8
37.4
39.4
%
1.20
101
1128
163
1653
0.93
0.12
6.3
4.2
4.6
4.8
mmol/l
1.53
153
1539
156
1584
0.94
0.12
5.8
3.8
1.3
1.2
mmol/l
0.56
144
1462
178
1764
1.07
0.08
26.4
15.3
86.7
71.9
umol/l
1.94
178
1764
13
142
0.91
0.06
2.9
2.9
41.3
70.8
ml/min/173m2
—
8
59
9
100
0.90
0.06
1.4
1.4
—
—
—
0
0
168
1688
0.97
0.02
6.8
4.7
2.6
2.8
mmol/l
2.59
154
1559
36
353
1.02
0.01
1.6
1.4
—
—
—
0
0
162
1619
1.00
0.00
5.6
4.4
6.8
5.8
mmol/l
4.24
147
1487
19
195
0.97
0.00
6.4
7.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
12.9
—
0
6
0
8
0.00
0.00
0.0
2.3
—
115.8
—
0
8
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
5.4
—
—
—
0
0
6
60
1.00
0.00
1.2
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
172.5
—
0
9
6
60
1.00
0.00
1.2
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYTHYPOSTINF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYTHYPOSTINF | 1.889 [1.3, 2.75] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.278 |
During the follow-up period (1.1.1998 — 31.12.2019), 115 out of 430 females with E4_HYTHYPOSTINF died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_HYTHYPOSTINF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | No data |
| 5 | 1.234% | No data |
| 10 | 2.848% | No data |
| 15 | 5.051% | No data |
| 20 | 9.149% | No data |
Relationships between endpoints
↥Index endpoint: E4_HYTHYPOSTINF – Postinfectious hypothyroidism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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