Postinfectious hypothyroidism

E4_HYTHYPOSTINF

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E03.3
  • Hospital discharge: ICD-9 2448A
  • Cause of death: ICD-10 E03.3
  • Cause of death: ICD-9 2448A

2 out of 7 registries used, show all original rules.

209

4. Check minimum number of events

None

209

5. Include endpoints

None

209

6. Filter based on genotype QC (FinnGen only)

203

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E03
Name in latin
Hypothyreosis postinfectiosa

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2062 1681 349
Only index persons 1434 1198 236
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.01
Only index persons 0.04 0.04 0.01
Median age at first event (years)
Whole population 55.61 56.08 52.28
Only index persons 48.62 49.33 45.03

-FinnGen-

Key figures

All Female Male
Number of individuals 203 168 35
Unadjusted period prevalence (%) 0.05 0.06 0.02
Median age at first event (years) 42.19 40.93 48.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
209
Matched controls
2090
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
1443.5
238.8
201
35
104
Kela drug reimbursment
Thyroid insufficiency
1948.2
187.0
154
*
2448A
ICD-9 Finland
Acquired hypothyroidism, Other specified acquired hypothyroidism[HYPOTHYREOSIS POST THYREOIDITIDEM]
+∞
172.8
141
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
400.3
147.4
133
9
E03.3
ICD-10 Finland
Postinfectious hypothyroidism
+∞
80.5
72
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
564.6
47.3
45
*
A10AA02, ,
ATC
18.8
47.3
40
26
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
16.9
43.7
39
28
E03
ICD-10 Finland
Other hypothyroidism
261.1
42.6
42
*
A10AA01, ,
ATC
18.1
40.9
35
23
E03.89
ICD-10 Finland
Other specified hypothyroidism
245.8
40.4
40
*
A10AB01
ATC
insulin (human); parenteral
15.3
40.3
38
30
A10AB04
ATC
insulin lispro; parenteral
16.6
39.2
35
25
T89
ICPC
Diabetes insulin dependent
13.4
35.4
36
32
A10AC01
ATC
insulin (human); parenteral
7.6
30.5
50
83
A10AB05
ATC
insulin aspart; parenteral
7.7
28.8
46
74
A10AE04
ATC
insulin glargine; parenteral
6.5
26.4
50
96
T86
ICPC
Hypothyroidism/myxoedema
282.4
25.2
25
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
25.1
24.4
34
16
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
21.2
21.2
31
17
A10AE05
ATC
insulin detemir; parenteral
7.7
20.6
31
46
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
18.0
17
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
55.0
17.3
20
*
H04AA01
ATC
glucagon; nasal, parenteral
25.6
16.8
23
10
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
17.3
16.7
26
17
103
Kela drug reimbursment
Diabetes, insulin-treated
3.5
16.4
84
340
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.4
15.5
77
304
XCK10
NOMESCO Finland
Photography of fundus of eye
4.6
14.3
38
96
E03.8
ICD-10 Finland
Other specified hypothyroidism
+∞
13.7
13
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
149.3
13.6
14
*
A10AD01
ATC
insulin (human); parenteral
14.4
12.7
21
16
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
10.2
11.8
23
25
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
32.1
11.8
15
5
A10AE06
ATC
insulin degludec; parenteral
10.1
11.3
22
24
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.6
11.2
42
136
H3603, E103,
ICD-10 Finland
63.3
10.7
12
*
K29.4
ICD-10 Finland
Chronic atrophic gastritis
13.1
10.0
17
14
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
57.7
9.7
11
*
SPAT1262
SPAT
Handing over of treatment supplies
3.0
9.6
49
191
B03BA03
ATC
hydroxocobalamin; parenteral
4.5
9.0
23
56
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
8.6
108
650
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
28.9
8.6
11
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
34.8
8.2
10
*
J01FF01
ATC
clindamycin; systemic
2.5
8.1
68
340
A12AA04
ATC
calcium carbonate; oral
23.1
8.1
11
5
4019X
ICD-9 Finland
Essential hypertension, Unspecified
7.9
7.8
17
23
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
7.8
52
232
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
10.6
7.7
14
14
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
7.5
76
411
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
82.9
7.5
8
*
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
82.9
7.5
8
*
107
Kela drug reimbursment
Pernicious anaemia
11.5
7.4
13
12
E06.3
ICD-10 Finland
Autoimmune thyroiditis
+∞
7.3
7
*
A11CC03
ATC
alfacalcidol; systemic
10.6
7.1
13
13
CKC12
NOMESCO Finland
Photocoagulation of retina
4.7
7.1
17
39
A10AA03, ,
ATC
14.4
7.0
11
8
A12BA01
ATC
potassium chloride; oral
4.4
7.0
18
44
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.5
6.9
17
40
N06AA09
ATC
amitriptyline; systemic
3.1
6.8
31
112
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
41.4
6.8
8
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
12.8
6.7
11
9
SPAT1263
SPAT
Sampling
2.1
6.5
97
608
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
72.0
6.5
7
*
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
9.7
6.4
12
13
E03.1
ICD-10 Finland
Congenital hypothyroidism without goitre
+∞
6.3
6
*
H03BB01
ATC
carbimazole; oral
27.6
6.3
8
*
H3600, E103,
ICD-10 Finland
27.6
6.3
8
*
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.2
6.2
63
337
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.1
6.2
27
95

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
183
1280
4.45
13.08
10.1
2.6
16.50
14.50
pmol/l
13.93
173
1167
125
781
2.49
9.40
7.9
5.4
56.37
57.41
%
0.45
116
738
126
797
2.46
9.13
8.1
5.5
28.41
28.32
%
0.03
116
752
120
745
2.43
9.03
7.8
5.5
0.68
0.68
%
0.02
109
693
123
781
2.40
8.67
8.5
5.7
9.13
8.20
%
2.91
114
735
129
841
2.39
8.50
7.7
5.4
1.82
1.86
e9/l
0.21
118
759
51
217
2.79
8.46
2.0
2.1
—
—
—
0
0
122
778
2.36
8.43
7.7
5.4
2.87
2.71
%
0.34
111
729
120
762
2.35
8.35
8.4
5.7
—
—
—
0
0
80
436
2.35
7.84
5.7
3.1
818.94
183.95
mg/l
0.40
56
264
125
825
2.28
7.72
7.4
5.4
0.59
0.56
e9/l
0.87
110
728
128
857
2.27
7.58
7.7
5.7
0.18
0.18
e9/l
0.20
114
769
124
827
2.23
7.32
7.5
5.4
0.04
0.04
e9/l
0.84
107
728
81
461
2.24
7.02
6.9
3.7
17.65
5.67
mg/mmol
1.16
55
277
94
572
2.17
6.87
3.1
2.9
—
—
—
0
0
20
54
3.99
6.82
3.0
4.4
—
—
—
0
0
120
809
2.13
6.66
11.1
5.5
1.21
1.22
mmol/l
1.06
99
697
101
641
2.11
6.53
2.0
1.9
108.15
95.83
pmol/l
1.10
49
313
136
974
2.13
6.29
6.8
3.8
7.87
6.60
mmol/l
4.45
126
914
108
722
2.03
5.89
9.6
4.7
1.21
1.22
mmol/l
0.76
97
669
78
464
2.09
5.85
5.7
2.9
6.30
6.85
mmol/l
0.62
67
391
55
291
2.21
5.53
1.7
1.7
1362.24
1278.33
nmol/l
0.13
50
221
152
1168
2.11
5.42
6.3
4.4
—
—
—
0
0
70
411
2.06
5.37
4.4
3.8
—
—
—
0
0
132
972
1.97
5.21
9.1
9.1
4.18
4.15
e9/l
0.05
120
855
11
15
7.67
5.21
1.5
1.2
—
—
—
0
0
37
179
2.30
4.56
2.1
1.5
—
—
—
0
0
61
359
1.99
4.55
2.0
1.8
1942.88
466.43
pmol/l
0.49
51
306
162
1316
2.03
4.40
9.5
6.8
82.76
77.03
u/l
0.61
156
1235
184
1573
2.42
4.31
12.0
3.5
1.77
1.87
mu/l
0.12
173
1440
77
499
1.86
4.27
2.5
2.0
100.40
199.53
u/l
1.81
72
466
30
138
2.37
4.14
6.0
4.1
—
—
—
0
0
26
112
2.51
4.12
4.5
4.9
0.50
0.71
%
—
5
35
29
132
2.39
4.09
5.0
4.6
1.06
0.77
%
—
8
46
104
750
1.77
3.99
9.2
13.7
1.25
1.21
inr
0.16
29
226
116
867
1.76
3.90
4.4
3.9
0.00
0.02
estimate
0.50
23
156
61
379
1.86
3.81
1.7
1.5
17.89
22.09
nmol/l
2.04
54
330
55
332
1.89
3.74
1.5
1.3
2.23
2.37
g/l
0.23
30
204
27
124
2.35
3.74
4.9
4.8
0.00
0.08
%
—
6
38
8
12
6.88
3.71
2.4
1.7
—
—
—
0
0
113
854
1.70
3.52
6.0
5.3
0.04
0.01
estimate
0.39
24
164
91
649
1.71
3.51
3.9
3.7
49.53
30.94
ng/l
0.45
60
436
7
10
7.20
3.39
2.7
1.3
—
—
—
0
0
112
852
1.68
3.35
4.4
3.9
0.00
0.00
estimate
-0.00
28
177
42
240
1.94
3.35
1.6
1.3
416.00
460.80
titre
—
10
50
53
327
1.83
3.34
3.1
2.8
498.76
515.08
mosm/kgh2o
0.21
45
277
69
461
1.74
3.33
4.6
3.9
—
—
—
0
0
71
485
1.70
3.14
3.9
3.5
—
—
—
0
0
35
194
1.97
3.04
1.7
1.3
—
—
—
0
0
25
123
2.17
2.96
1.3
1.1
—
—
—
0
0
56
365
1.73
2.91
1.4
1.2
0.92
2.08
u/ml
—
6
104
54
349
1.74
2.89
2.9
2.3
6.42
5.61
e6/l
0.15
46
313
9
25
3.71
2.60
4.1
2.0
—
—
—
0
0
13
50
2.71
2.58
4.8
2.8
0.36
0.14
g/l
—
8
16
28
153
1.96
2.53
6.2
2.9
—
—
—
0
0
94
719
1.56
2.53
7.0
3.5
34.88
35.80
g/l
0.86
88
673
64
449
1.61
2.48
3.8
2.7
—
—
—
0
0
151
1290
1.61
2.46
6.9
4.2
13.38
11.68
mm/h
0.89
136
1192
94
724
1.54
2.43
11.3
9.4
0.00
0.00
e9/l
0.01
78
597
9
27
3.44
2.42
1.1
1.2
—
—
—
0
0
9
27
3.44
2.42
1.9
2.0
—
—
—
0
0
51
341
1.66
2.38
1.5
1.3
24.81
31.63
iu/ml
0.21
17
117
62
437
1.60
2.35
5.0
6.8
—
—
—
0
0
8
23
3.57
2.29
4.9
3.7
—
—
—
0
0
56
388
1.61
2.27
1.7
1.6
1.29
1.06
mg/l
0.20
42
311
64
462
1.56
2.17
3.8
2.7
0.61
0.38
e6/l
0.31
51
341
68
498
1.54
2.16
6.0
3.1
7.40
7.40
ph
0.16
12
97
68
499
1.54
2.14
3.7
2.9
33.19
210.16
e6/l
0.72
54
379
18
90
2.09
2.07
1.3
1.2
126.03
91.62
iu/ml
—
10
31
88
688
1.48
2.03
3.8
3.6
6.00
5.91
ph
—
5
56
10
38
2.71
2.03
1.2
1.1
—
—
—
0
0
48
329
1.60
2.02
1.5
1.3
4.35
10.20
u/ml
0.84
21
127
7
21
3.41
1.98
2.4
1.5
—
—
—
0
0
20
107
1.96
1.94
8.7
3.0
149.71
77.52
ng/l
0.86
15
98
15
72
2.17
1.91
16.9
6.9
—
—
—
0
0
187
1722
1.82
1.91
22.3
13.0
21.44
22.43
mg/l
0.16
163
1346
188
1736
1.83
1.87
25.7
14.5
139.01
139.70
mmol/l
2.85
182
1691
63
468
1.50
1.84
4.8
4.1
0.00
0.01
estimate
0.50
23
167
94
756
1.44
1.83
4.3
2.6
68.48
87.74
ug/l
1.79
89
696
23
132
1.83
1.82
5.0
3.6
1.22
1.23
mmol/l
0.52
18
119
18
95
1.98
1.82
1.8
1.3
—
—
—
0
0
6
18
3.40
1.76
1.0
1.2
—
—
—
0
0
5
13
3.91
1.72
1.0
1.1
—
—
—
0
0
14
69
2.10
1.69
1.2
1.3
—
—
—
0
0
22
128
1.80
1.68
4.3
3.4
—
—
—
0
0
17
91
1.94
1.66
7.2
4.4
25.87
25.13
mmol/l
0.35
17
91
76
599
1.42
1.61
4.4
3.5
123.50
68.53
e6/l
0.36
60
415
187
1739
1.72
1.61
26.0
14.5
3.98
3.95
mmol/l
0.81
181
1687
7
26
2.75
1.59
1.4
1.2
29.11
12.37
u/l
—
7
21
29
188
1.63
1.53
1.3
1.3
—
—
—
0
0
68
531
1.42
1.51
2.5
2.1
—
—
—
0
0
51
379
1.46
1.47
4.5
4.1
1.01
1.01
kg/l
0.30
12
56
9
39
2.37
1.45
2.4
1.9
1.78
1.35
mg/l
—
9
34
5
16
3.17
1.44
1.8
1.0
285.00
276.64
mosm/kgh2o
—
5
11
17
97
1.82
1.39
10.4
4.5
—
—
—
0
0
23
144
1.67
1.39
3.7
3.0
—
—
—
0
0
9
41
2.25
1.39
1.1
1.0
—
—
—
0
0
73
585
1.38
1.38
2.6
3.1
2.33
2.36
mmol/l
0.86
65
522
53
402
1.43
1.37
2.5
2.2
337.02
7177.96
umol/l
2.28
42
358
8
34
2.41
1.30
1.0
3.6
—
—
—
0
0
5
118
0.41
1.29
1.2
1.4
—
—
—
0
0
24
156
1.61
1.27
13.7
6.2
94.95
95.86
%
0.38
24
151
34
241
1.49
1.24
3.9
2.8
2.48
3.92
e6/l
0.46
18
124
7
30
2.38
1.13
1.1
1.6
—
—
—
0
0
22
145
1.58
1.11
3.8
3.7
—
—
—
0
0
19
121
1.63
1.10
13.2
5.2
—
—
—
0
0
39
294
1.40
1.05
6.1
3.5
548.73
222.66
ng/l
0.34
30
211
17
107
1.64
1.03
1.4
1.6
—
—
—
0
0
52
639
0.75
0.99
3.7
2.7
—
—
—
0
0
58
471
1.32
0.98
1.8
1.6
1.46
1.36
mmol/l
0.35
50
402
16
101
1.63
0.97
1.3
1.8
—
—
—
0
0
33
247
1.40
0.93
1.3
1.2
—
—
—
0
0
6
28
2.18
0.92
4.0
2.0
—
—
—
0
0
169
1586
1.34
0.90
9.4
5.4
46.29
39.30
mmol/mol
7.52
157
1489
6
30
2.03
0.87
1.7
2.1
3.34
5.96
e9/l
—
6
30
6
31
1.96
0.85
1.7
2.7
53.50
64.77
%
—
6
31
82
709
1.26
0.84
2.1
2.0
—
—
—
0
0
6
32
1.90
0.82
4.0
1.6
136.50
132.29
g/l
—
6
21
8
47
1.73
0.81
3.5
4.3
11.43
33.88
mg/l
—
8
30
6
33
1.84
0.79
1.0
1.1
—
—
—
0
0
5
24
2.11
0.75
6.6
3.0
—
—
—
0
0
186
1785
1.38
0.72
20.9
12.3
—
—
—
0
0
14
93
1.54
0.71
3.4
4.3
—
—
—
0
0
14
93
1.54
0.71
4.5
2.5
1.42
1.15
%
0.69
14
93
27
206
1.36
0.70
1.8
1.5
—
—
—
0
0
22
163
1.39
0.67
1.3
1.4
—
—
—
0
0
12
176
0.66
0.65
1.3
1.8
—
—
—
0
0
0
20
0.00
0.60
0.0
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
8
52
1.56
0.60
3.9
5.5
—
—
—
0
0
10
64
1.59
0.59
5.7
5.3
—
—
—
0
0
6
35
1.73
0.58
2.7
2.3
—
—
—
0
0
20
151
1.36
0.56
2.0
1.5
—
—
—
0
0
6
37
1.64
0.56
1.2
1.3
—
—
—
0
0
14
99
1.44
0.55
12.4
6.6
93.37
94.14
%
0.19
14
99
6
40
1.51
0.52
2.0
2.1
—
—
—
0
0
14
101
1.41
0.51
1.4
1.2
—
—
—
0
0
7
48
1.47
0.47
3.4
3.1
—
—
—
0
0
30
248
1.24
0.46
1.7
1.7
—
—
—
0
0
13
95
1.39
0.45
1.3
1.4
—
—
—
0
0
6
92
0.64
0.43
1.2
1.1
—
—
—
0
0
187
1820
1.26
0.42
15.6
9.7
25.77
24.71
u/l
0.37
181
1764
5
33
1.53
0.41
1.2
1.2
—
—
—
0
0
5
33
1.53
0.41
2.6
2.5
2.82
2.74
mmol/l
—
5
25
5
33
1.53
0.41
2.6
2.5
8.66
8.80
kpa
—
5
33
5
33
1.53
0.41
2.6
2.5
5.34
5.08
kpa
—
5
33
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
2.8
—
3.69
—
0
17
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
13
97
1.36
0.40
14.4
7.7
23.03
24.77
mmol/l
0.68
13
91
5
36
1.40
0.38
1.0
1.3
—
—
—
0
0
13
168
0.76
0.37
1.5
1.3
—
—
—
0
0
12
91
1.34
0.34
2.0
2.3
—
—
—
0
0
37
326
1.16
0.31
2.4
2.4
2.44
2.45
mmol/l
0.35
31
281
7
53
1.33
0.31
3.9
3.7
—
—
—
0
0
19
225
0.83
0.28
1.1
1.2
—
—
—
0
0
43
389
1.13
0.26
4.9
3.8
—
—
—
0
0
9
73
1.24
0.26
1.1
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
12.40
—
0
12
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
3.2
—
—
—
0
0
7
63
1.11
0.17
6.9
10.8
—
—
—
0
0
6
77
0.77
0.16
1.2
1.3
—
—
—
0
0
18
159
1.14
0.15
1.3
1.3
—
—
—
0
0
9
81
1.12
0.15
2.3
2.1
—
—
—
0
0
11
129
0.84
0.15
1.3
1.4
—
—
—
0
0
183
1808
1.10
0.13
26.4
15.2
86.44
71.93
umol/l
1.98
183
1808
17
153
1.12
0.11
1.4
1.4
—
—
—
0
0
121
1183
1.05
0.11
4.4
3.7
—
—
—
0
0
191
1893
1.10
0.10
33.2
19.4
263.29
256.18
e9/l
0.77
185
1855
5
48
1.04
0.09
1.8
1.1
—
—
—
0
0
191
1894
1.10
0.09
33.0
19.4
6.92
6.59
e9/l
1.21
185
1847
167
1689
0.94
0.09
6.2
4.2
1.56
1.56
mmol/l
0.05
152
1567
191
1895
1.09
0.08
33.1
19.3
4.40
4.43
e12/l
0.47
185
1849
191
1895
1.09
0.08
33.3
19.3
38.75
39.61
%
0.96
178
1781
5
61
0.82
0.08
2.2
1.5
—
—
—
0
0
117
1149
1.04
0.08
4.3
2.7
71.54
41.64
u/l
1.51
109
1085
161
1625
0.96
0.06
5.7
3.8
1.30
1.23
mmol/l
0.73
148
1501
168
1694
0.96
0.05
6.3
4.2
4.61
4.77
mmol/l
1.51
157
1581
151
1495
1.04
0.05
25.3
15.5
15.79
14.92
%
0.81
145
1476
167
1661
1.03
0.02
5.7
4.4
6.75
5.84
mmol/l
4.24
152
1528
44
431
1.03
0.02
1.4
1.4
—
—
—
0
0
12
125
0.96
0.00
1.0
1.3
—
—
—
0
0
6
62
0.97
-0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
19.91
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
5.0
—
44.00
—
0
8
0
6
0.00
-0.00
0.0
2.0
—
139.83
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
173
1730
1.00
-0.00
6.7
4.7
2.60
2.80
mmol/l
2.42
159
1603
0
5
0.00
-0.00
0.0
1.0
—
4.94
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
9.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
10.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint E4_HYTHYPOSTINF and mortality.

Females

Parameter HR [95% CI] p-value
E4_HYTHYPOSTINF 1.889 [1.3, 2.75] < 0.001
Birth year 0.995 [0.99, 1.0] 0.278

During the follow-up period (1.1.1998 — 31.12.2019), 115 out of 430 females with E4_HYTHYPOSTINF died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_HYTHYPOSTINF.

N-year risk Females Males
1 0.184% No data
5 1.234% No data
10 2.848% No data
15 5.051% No data
20 9.149% No data

Relationships between endpoints

Index endpoint: E4_HYTHYPOSTINF – Postinfectious hypothyroidism

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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