mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
241 |
4. Check minimum number of eventsNone |
241 |
5. Include endpointsNone |
241 |
6. Filter based on genotype QC (FinnGen only) |
228 |
Control definitions (FinnGen only)
- Control exclude
- F5_MENTRET
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F70-F79
- Name in latin
- Retardatio mentalis moderata
Similar endpoints
↥List of similar endpoints to
Moderate mental retardation
based on the number of shared cases.
Similar with more cases:
- Mental retardation
- Mental retardation, excluding more controls
- Mental retardation, wide definition
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8871 | 3898 | 4958 |
| Only index persons | 7776 | 3383 | 4393 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.11 | 0.14 |
| Only index persons | 0.15 | 0.12 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 20.27 | 22.12 | 18.75 |
| Only index persons | 19.66 | 21.47 | 18.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 228 | 111 | 117 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | 21.68 | 22.82 | 20.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 241
- Matched controls
- 2410
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
126.5
110
*
N03AG01
ATC
valproic acid; systemic, rectal
21.9
110.8
97
72
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
20.3
95.3
84
62
N05AX08
ATC
risperidone; systemic
15.0
89.0
98
105
G40.9
ICD-10 Finland
Epilepsy, unspecified
29.5
87.3
62
28
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
+∞
80.9
73
*
F71.1
ICD-10 Finland
Moderate mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
80.9
73
*
N05AA02
ATC
levomepromazine; systemic
20.9
65.4
53
32
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
+∞
63.4
58
*
N05BA01
ATC
diazepam; systemic, rectal
9.7
60.7
91
142
P85
ICPC
Mental retardation
+∞
59.9
55
*
N03AF01
ATC
carbamazepine; oral, rectal
17.2
57.1
51
37
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
+∞
53.1
49
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
8.5
51.1
83
140
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
576.1
49.2
47
*
F71.9
ICD-10 Finland
Moderate mental retardation, without mention of impairment of behaviour
+∞
46.4
43
*
N03AX14
ATC
levetiracetam; systemic
17.0
44.4
39
27
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
20.3
43.7
35
20
N03AX09
ATC
lamotrigine; oral
10.8
43.1
52
60
N03AX11
ATC
topiramate; oral
15.3
41.8
39
30
N05CD08
ATC
midazolam; nasal, systemic
16.6
41.7
37
26
F83
ICD-10 Finland
Mixed specific developmental disorders
16.9
39.9
35
24
F70.9
ICD-10 Finland
Mild mental retardation, Without mention of impairment of behaviour
444.2
39.2
38
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
8.0
36.4
57
90
N05BA09
ATC
clobazam; oral
54.5
35.0
41
9
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
+∞
30.9
29
*
183
Kela drug reimbursment
Lamotrigin and topiramate
33.3
28.6
37
13
R56.8
ICD-10 Finland
Other and unspecified convulsions
7.1
27.5
46
77
N05AH03
ATC
olanzapine; systemic
6.6
27.3
50
92
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
6.0
23.7
47
93
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.1
22.5
56
136
A06AD11
ATC
lactulose; oral
5.1
22.4
55
132
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
25.2
22.4
31
14
N03AF02
ATC
oxcarbazepine; oral
9.0
22.2
29
36
F71
ICD-10 Finland
Moderate mental retardation
+∞
21.1
20
*
N05AC02
ATC
thioridazine; oral
26.2
20.5
28
12
N05BA06
ATC
lorazepam; systemic, sublingual
8.4
20.4
28
37
N05AX12
ATC
aripiprazole; systemic
6.8
20.1
34
57
F29
ICD-10 Finland
Unspecified nonorganic psychosis
6.8
20.1
34
57
31299
ICD-8 Finland
Moderate mental retardation, Other and unspecified
+∞
20.1
19
*
N05AH04
ATC
quetiapine; oral
3.8
19.8
79
272
N05AD01
ATC
haloperidol; systemic
18.1
18.9
29
18
A28
ICPC
Limited function/disability NOS
4.5
18.3
52
139
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.6
18.1
79
287
R62.0
ICD-10 Finland
Delayed milestone
14.7
18.0
30
23
F72.0
ICD-10 Finland
Severe mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
17.9
17
*
N04AA02
ATC
biperiden; systemic
23.1
17.7
25
12
N03AE01
ATC
clonazepam; systemic
6.9
17.6
29
47
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
21.3
17.3
25
13
OAB43, ,
SPAT
0.1
17.1
5
520
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
+∞
16.9
16
*
G03DC03
ATC
lynestrenol; oral
18.4
16.5
25
15
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.4
16.2
47
127
N03AG04
ATC
vigabatrin; oral
170.6
15.7
16
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.3
15.6
45
121
3180A
ICD-9 Finland
Other specified mental retardation, Moderate mental retardation[KESKIVAIKEA ÄLYLL KEHITYSVAMMAISUUS,EI KÄYTÄYT.HÄIR]
+∞
14.7
14
*
L28
ICPC
Limited function/disability (L)
3.9
14.5
49
148
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
25.6
14.0
19
8
Z31.5
ICD-10 Finland
Genetic counselling
4.8
13.6
33
77
181
Kela drug reimbursment
Retigabine and vigabatrin
148.0
13.6
14
*
78159
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Laesio loquendi alia sive NUD
148.0
13.6
14
*
N05AF03
ATC
chlorprothixene; systemic
13.2
13.4
23
19
WYA20
NOMESCO Finland
Home visit
30.3
13.1
17
6
G40.10
ICD-10 Finland
Simple partial seizures
34.1
12.7
16
5
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.6
12.7
48
156
G40.89
ICD-10 Finland
Other epilepsy
26.0
12.6
17
7
N03AX23
ATC
brivaracetam; systemic
49.3
12.0
14
*
TLC00
NOMESCO Finland
Insertion of intrauterine device
5.2
12.0
26
55
EBA15
NOMESCO Finland
Extraction of multiple teeth
9.4
11.8
24
28
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
20.2
11.8
17
9
R1260
NOMESCO Finland
Evaluation of communicative skills
14.6
11.7
19
14
F79.1
ICD-10 Finland
Unspecified mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
11.5
11
*
Q90.9
ICD-10 Finland
Down syndrome, unspecified
+∞
11.5
11
*
N03AF03
ATC
rufinamide; oral
+∞
11.5
11
*
N03AX22
ATC
perampanel; oral
37.0
11.4
14
*
H52.2
ICD-10 Finland
Astigmatism
6.0
11.4
21
38
G40.39
ICD-10 Finland
Other or unspecified generalized epileptic syndromes with atonic, clonic, myoclonic or tonic-clonic seizures
26.5
11.3
15
6
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.0
10.7
55
214
ADB00
NOMESCO Finland
Implantation of vagus nerve stimulating device
114.8
10.5
11
*
3199A
ICD-9 Finland
Unspecified mental retardation[MUU ÄLYLLINEN KEHITYSVAMMAISUUS,EI KÄYTTÄYTYMIHÄIRI]
+∞
10.5
10
*
F72.1
ICD-10 Finland
Severe mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
10.5
10
*
3170A
ICD-9 Finland
Mild mental retardation[LIEVÄ ÄLYLL.KEHITYSVAMMAISUUS,EI KÄYTÄYTYM.HÄIRIÖTÄ]
+∞
10.5
10
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.8
10.5
67
294
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.9
10.3
32
90
Z2446
NOMESCO Finland
Social worker
3.4
10.0
39
128
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.1
9.9
29
78
N03AX18
ATC
lacosamide; systemic
27.3
9.9
13
5
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.4
9.8
20
40
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.4
9.8
20
40
N05AH02
ATC
clozapine; systemic
8.6
9.6
20
25
M01AH05
ATC
etoricoxib; oral
0.3
9.5
42
919
R5110, ,
SPAT
5.5
9.5
19
37
RL140, ,
NOMESCO Finland
18.5
9.5
14
8
N05AA01
ATC
chlorpromazine; systemic, rectal
18.5
9.5
14
8
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
31.4
9.5
12
*
G40.00
ICD-10 Finland
Benign childhood epilepsy with centrotemporal EEG spikes
103.9
9.5
10
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.6
9.5
68
315
31209
ICD-8 Finland
Moderate mental retardation, Following infections and intoxications, Unspecified
+∞
9.4
9
*
199
Kela drug reimbursment
Rufinamide
+∞
9.4
9
*
SDA02
NOMESCO Finland
Periodontal treatment, brief
2.3
9.2
112
658
H50.1
ICD-10 Finland
Divergent concomitant strabismus
16.4
9.1
14
9
K03.66
ICD-10 Finland
Tooth plaque
3.1
9.0
43
160
N05AF05
ATC
zuclopenthixol; systemic
25.1
9.0
12
5
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
14.8
8.8
14
10
SPAT1229
SPAT
Assessment of need for aid
5.1
8.7
19
40
F84.0
ICD-10 Finland
Childhood autism
51.9
8.7
10
*
H50.30
ICD-10 Finland
Intermittent esotropy
12.2
8.7
15
13
XA800
NOMESCO Finland
Neuropsychological investigation
3.9
8.7
27
76
N05CD07
ATC
temazepam; oral
3.7
8.7
29
86
M03BX02
ATC
tizanidine; oral
0.4
8.6
45
924
N03AX15
ATC
zonisamide; oral
28.7
8.6
11
*
N05AD03
ATC
melperone; systemic
28.7
8.6
11
*
N05BA04
ATC
oxazepam; oral
2.5
8.6
66
315
N06AB04
ATC
citalopram; systemic
2.8
8.5
50
208
Q99.8
ICD-10 Finland
Other specified chromosome abnormalities
93.2
8.5
9
*
M01AB05
ATC
diclofenac; systemic, rectal
0.4
8.5
51
985
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
7.5
8.4
19
27
F79
ICD-10 Finland
Unspecified mental retardation
+∞
8.4
8
*
Q85.1
ICD-10 Finland
Tuberous sclerosis
+∞
8.4
8
*
N03AX24
ATC
cannabidiol; oral
+∞
8.4
8
*
R33
ICD-10 Finland
Retention of urine
4.4
8.2
21
51
34599
ICD-8 Finland
Epilepsy, Other and unspecified
34.6
8.1
10
*
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
4.7
8.1
19
43
K05.10
ICD-10 Finland
Gingivitis (chronic) NOS
2.5
8.0
60
282
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
2.4
7.8
66
327
F20.9
ICD-10 Finland
Schizophrenia, unspecified
7.9
7.8
17
23
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.1
7.8
*
244
N88
ICPC
Epilepsy
19.1
7.7
11
6
H50.31
ICD-10 Finland
Intermittent exotropia
9.3
7.7
15
17
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
7.5
43
176
RT490, ,
NOMESCO Finland
82.5
7.5
8
*
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
0.1
7.4
*
257
WX892
NOMESCO Finland
Monitored bed care
3.5
7.3
26
80
31199
ICD-8 Finland
Mild mental retardation, Other and unspecified
+∞
7.3
7
*
3180B
ICD-9 Finland
Other specified mental retardation, Moderate mental retardation[KESKIVAIKEA ÄLYLL KEHITYSVAMMAISUUS JA KÄYTÄYT.HÄIR]
+∞
7.3
7
*
Q90.0
ICD-10 Finland
Trisomy 21, meiotic nondisjunction
+∞
7.3
7
*
31099
ICD-8 Finland
Borderline mental retardation, Other and unspecified
+∞
7.3
7
*
3170B
ICD-9 Finland
Mild mental retardation[LIEVÄ ÄLYLL.KEHITYSVAMMAISUUS,JOSSA KÄYTÄYTYM.HÄIRI]
+∞
7.3
7
*
G40.1
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
+∞
7.3
7
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.2
7.3
20
51
JDB10
NOMESCO Finland
Percutaneous gastrostomy
16.4
7.3
11
7
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
8.3
7.2
15
19
OAA65, ,
SPAT
0.1
7.2
*
252
G41.9
ICD-10 Finland
Status epilepticus, unspecified
31.0
7.2
9
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
7.2
79
437
Z50.5
ICD-10 Finland
Speech therapy
4.4
7.1
18
43
K59.09
ICD-10 Finland
Constipation, unspecified
3.6
7.0
24
72
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.9
7.0
35
133
SCA02
NOMESCO Finland
Preventive oral health care
2.3
7.0
66
342
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.4
6.9
55
265
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
41.2
6.8
8
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.0
6.8
32
118
N05AB03
ATC
perphenazine; systemic, rectal
6.2
6.7
17
29
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
23.3
6.7
9
*
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
9.1
6.6
13
15
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
3.1
6.5
29
103
SPAT1325
SPAT
Vaccination
2.1
6.5
92
556
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.4
6.5
24
76
OAA67, ,
SPAT
0.1
6.5
*
213
N05AC01
ATC
periciazine; systemic
71.7
6.5
7
*
3454A
ICD-9 Finland
Epilepsy, Partial epilepsy, with impairment of consciousness[EPILEPSIA GENERALISATA SECUNDARIA]
71.7
6.5
7
*
3459X
ICD-9 Finland
Epilepsy, unspecified
71.7
6.5
7
*
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
71.7
6.5
7
*
7834D
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Lack of expected normal physiological development[LAPSEN NORMAALIN KEHITTYMISEN HIDASTUMINEN]
71.7
6.5
7
*
M41.4
ICD-10 Finland
Neuromuscular scoliosis
71.7
6.5
7
*
EBA00
NOMESCO Finland
Extraction of tooth
2.0
6.4
113
738
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
5.8
6.4
17
31
K05.18
ICD-10 Finland
Chronic gingivitis
3.0
6.4
29
104
4451
FHL
Guitar cutting
4.1
6.4
18
47
RS222, ,
NOMESCO Finland
9.6
6.4
12
13
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.0
6.3
92
561
G40.09
ICD-10 Finland
Other or unspecified partial (focal) idiopathic epilepsy or epileptic syndrome with local onset
18.6
6.3
9
5
3046, ,
Kela drug reimbursment
+∞
6.3
6
*
F72.9
ICD-10 Finland
Severe mental retardation, without mention of impairment of behaviour
+∞
6.3
6
*
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
+∞
6.3
6
*
W19
ICD-10 Finland
Unspecified fall
2.8
6.3
33
129
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
27.5
6.3
8
*
OAA62, ,
SPAT
0.0
6.2
*
152
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.5
6.2
43
194
D01AC02
ATC
miconazole; topical
3.3
6.1
24
79
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
133
814
2.41
10.22
10.7
9.1
1.21
1.22
mmol/l
0.05
118
714
49
194
2.92
9.20
8.2
5.6
1.93
1.51
mmol/l
0.32
35
146
122
758
2.23
8.58
9.8
8.8
1.22
1.22
mmol/l
0.13
114
710
55
257
2.48
7.37
1.9
1.8
—
—
—
0
0
15
20
7.92
7.01
14.3
23.1
1467.27
1290.40
nmol/l
0.30
15
20
42
181
2.60
6.62
1.8
1.7
—
—
—
0
0
102
640
2.03
6.52
12.5
10.5
1.27
1.22
inr
0.27
34
186
42
185
2.54
6.33
1.8
1.7
—
—
—
0
0
14
20
7.36
6.32
12.6
13.8
933.14
724.50
nmol/l
0.61
14
20
49
234
2.37
6.20
5.3
8.5
0.60
1.84
mmol/l
2.31
42
177
36
155
2.55
5.67
7.1
12.2
2.77
1.31
mmol/l
1.69
27
123
43
208
2.30
5.25
1.7
1.5
1098.78
1245.39
nmol/l
0.61
37
166
24
90
2.85
4.92
1.8
1.3
—
—
—
0
0
121
866
1.80
4.77
4.9
3.3
0.00
0.00
estimate
-0.00
21
141
118
842
1.79
4.67
6.0
6.6
8.45
12.50
umol/l
4.26
112
793
120
861
1.78
4.66
4.8
3.3
0.00
0.00
estimate
-0.00
23
156
71
437
1.89
4.52
5.0
3.6
0.00
0.01
estimate
0.50
22
145
119
857
1.77
4.52
6.5
4.6
0.00
0.00
estimate
-0.00
22
150
20
73
2.90
4.30
1.6
1.5
—
—
—
0
0
49
270
2.02
4.29
1.6
1.6
513.05
460.88
pmol/l
0.56
43
229
165
1325
1.78
4.12
7.2
6.6
88.42
87.01
u/l
0.11
158
1247
82
542
1.78
4.10
3.1
3.2
43.84
36.32
ng/l
0.14
59
332
65
410
1.80
3.76
5.4
3.1
1.02
1.02
kg/l
0.75
17
54
52
307
1.88
3.71
1.5
1.5
21.92
22.02
nmol/l
0.01
47
265
33
577
0.50
3.37
1.9
1.7
—
—
—
0
0
80
553
1.67
3.30
1.8
1.7
106.07
95.54
pmol/l
0.84
43
276
20
87
2.42
3.10
4.3
6.9
1.24
1.41
%
0.30
20
87
98
725
1.59
3.03
2.9
2.7
78.09
71.30
nmol/l
1.31
90
668
34
189
1.93
2.89
6.4
8.6
104.56
104.20
mmol/l
0.10
34
189
17
71
2.50
2.87
6.7
4.5
56.15
54.10
%
0.11
17
71
12
39
3.18
2.81
1.1
1.5
—
—
—
0
0
12
39
3.18
2.81
1.1
2.6
—
—
—
0
0
88
657
1.53
2.53
5.5
3.3
—
—
—
0
0
26
138
1.99
2.53
6.0
5.5
63.69
65.60
ng/l
0.06
26
131
18
83
2.26
2.48
3.3
7.1
0.73
0.64
%
0.59
18
83
0
66
0.00
2.45
0.0
1.6
—
—
—
0
0
58
396
1.61
2.44
3.5
3.8
7.56
12.41
mg/mmol
0.59
40
266
19
361
0.49
2.43
3.5
2.3
—
—
—
0
0
5
8
6.35
2.38
9.6
2.5
—
—
—
0
0
22
394
0.51
2.35
3.3
2.4
—
—
—
0
0
55
376
1.60
2.30
3.0
3.6
835.61
1057.78
ng/l
0.32
48
311
44
288
1.65
2.18
3.4
3.5
367.71
395.36
ng/l
0.03
34
207
10
37
2.77
2.09
1.8
1.6
—
—
—
0
0
19
97
2.04
2.07
2.5
4.4
69.61
65.45
g/l
1.52
19
89
139
1171
1.44
2.06
16.0
10.3
4.19
3.95
e9/l
0.56
126
1015
80
609
1.47
2.03
4.4
3.5
—
—
—
0
0
0
53
0.00
1.89
0.0
1.5
—
—
—
0
0
20
345
0.54
1.89
3.8
3.6
22.68
20.42
%
—
5
127
162
1420
1.43
1.83
4.7
3.7
14.37
14.66
pmol/l
0.67
151
1311
56
415
1.46
1.60
2.0
2.9
2.63
2.80
mg/l
0.30
51
358
20
116
1.79
1.54
2.1
2.0
—
—
—
0
0
13
65
2.06
1.51
1.4
1.9
1.43
1.29
g/l
0.25
13
57
9
39
2.36
1.44
6.2
4.1
53.89
56.41
%
—
9
39
5
16
3.17
1.44
2.4
1.6
—
—
—
0
0
25
159
1.64
1.41
5.7
6.4
—
—
—
0
0
15
256
0.56
1.38
1.7
2.5
0.92
0.63
ug/l
—
7
141
32
220
1.52
1.32
3.9
4.6
4.83
9.35
umol/l
1.49
24
198
6
24
2.54
1.31
1.3
1.6
—
—
—
0
0
21
131
1.66
1.28
5.6
3.4
—
—
—
0
0
146
1614
0.76
1.27
3.6
3.4
1.38
1.26
mmol/l
1.08
137
1502
12
212
0.54
1.25
2.2
2.1
—
—
—
0
0
156
1707
0.76
1.24
4.7
4.0
2.54
2.78
mmol/l
4.14
149
1590
11
56
2.01
1.24
2.2
2.1
—
—
—
0
0
5
19
2.66
1.22
1.4
1.8
—
—
—
0
0
154
1684
0.76
1.19
4.0
3.8
4.27
4.60
mmol/l
5.34
148
1583
5
20
2.53
1.15
1.4
1.8
—
—
—
0
0
5
20
2.53
1.15
1.4
1.8
—
—
—
0
0
181
1670
1.34
1.14
5.7
4.3
1.94
1.89
mu/l
0.19
170
1547
153
1671
0.77
1.14
4.0
3.7
1.29
1.42
mmol/l
3.93
146
1556
26
178
1.52
1.11
3.3
4.7
209.35
259.84
u/l
1.84
26
170
18
274
0.63
1.08
1.2
1.3
17.19
8.09
u/ml
—
7
98
61
490
1.33
1.08
4.8
3.3
0.37
0.27
e6/l
0.22
48
370
16
250
0.61
1.08
1.3
1.4
—
—
—
0
0
10
52
1.96
1.08
2.3
1.9
—
—
—
0
0
7
36
1.97
0.98
2.0
1.3
—
—
—
0
0
8
44
1.85
0.86
1.4
2.5
128.88
132.97
g/l
—
8
30
50
404
1.30
0.85
2.6
2.6
—
—
—
0
0
171
1598
1.24
0.78
14.3
9.9
102.18
90.87
ml/min/173m2
4.15
128
1234
6
34
1.78
0.77
1.3
1.6
—
—
—
0
0
88
771
1.22
0.76
2.8
2.8
—
—
—
0
0
36
286
1.30
0.70
3.7
3.1
3.10
1.77
e6/l
0.32
21
162
9
58
1.57
0.70
1.1
1.9
—
—
—
0
0
9
59
1.55
0.69
1.2
1.8
—
—
—
0
0
5
30
1.68
0.62
1.8
1.5
—
—
—
0
0
12
173
0.68
0.60
2.1
2.0
—
—
—
0
0
6
37
1.64
0.56
1.0
1.8
—
—
—
0
0
10
144
0.68
0.51
1.0
1.2
—
—
—
0
0
10
67
1.51
0.50
2.2
1.9
—
—
—
0
0
7
45
1.57
0.49
1.0
1.2
—
—
—
0
0
7
45
1.57
0.49
1.0
1.2
—
—
—
0
0
7
48
1.47
0.47
2.3
2.9
4.43
3.26
e6/l
—
7
38
7
48
1.47
0.47
2.4
2.9
455.29
308.82
e6/l
—
7
38
153
1605
0.87
0.44
3.6
3.6
—
—
—
0
0
5
31
1.63
0.43
1.2
2.0
—
—
—
0
0
43
372
1.19
0.43
2.3
2.9
1.25
1.21
mg/l
0.04
36
280
5
33
1.53
0.41
1.2
1.8
—
—
—
0
0
5
33
1.53
0.41
1.2
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
6.2
—
39.40
—
0
5
0
18
0.00
0.40
0.0
4.1
—
—
—
0
0
15
115
1.32
0.40
2.9
2.5
76.80
76.88
ml/min/173m2
—
5
43
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
6
42
1.44
0.36
1.2
1.8
—
—
—
0
0
6
42
1.44
0.36
1.2
1.8
—
—
—
0
0
197
1916
1.15
0.34
19.9
12.0
25.26
22.42
mg/l
0.67
167
1425
34
297
1.17
0.31
3.0
3.0
0.46
0.79
e6/l
0.64
17
173
7
54
1.31
0.30
1.3
1.4
—
—
—
0
0
216
2196
0.84
0.29
32.5
17.7
38.50
40.89
%
3.55
197
2092
5
75
0.66
0.26
1.0
1.3
—
—
—
0
0
9
73
1.24
0.26
1.4
1.8
—
—
—
0
0
6
84
0.71
0.24
1.3
1.3
—
—
—
0
0
64
595
1.10
0.24
1.4
1.5
0.36
1.58
u/ml
3.91
16
142
5
38
1.32
0.23
1.0
1.5
—
—
—
0
0
12
97
1.25
0.23
3.9
8.3
101.75
92.11
%
1.11
12
97
0
11
0.00
0.21
0.0
2.3
—
108.91
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
8
105
0.75
0.21
2.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
8.35
—
0
12
5
43
1.17
0.21
1.6
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
10
80
1.26
0.21
4.5
6.3
174.50
175.45
%
—
10
80
80
839
0.93
0.18
3.2
3.0
101.58
90.58
ug/l
0.36
72
784
7
62
1.13
0.17
1.0
1.0
—
14.84
—
0
7
168
1644
1.07
0.16
4.6
3.7
6.05
5.79
mmol/l
0.98
161
1516
130
1337
0.94
0.16
4.5
4.3
12.40
9.08
mm/h
1.68
125
1246
11
129
0.85
0.15
1.1
1.2
19.86
142.48
iu/ml
—
5
46
17
150
1.14
0.15
4.0
4.0
34.83
31.13
%
0.78
12
106
7
86
0.81
0.15
1.0
1.7
—
—
—
0
0
5
46
1.09
0.09
1.6
2.7
—
—
—
0
0
5
46
1.09
0.09
1.0
1.8
—
—
—
0
0
6
72
0.83
0.07
1.0
1.1
—
—
—
0
0
6
73
0.82
0.07
1.0
1.1
—
—
—
0
0
127
1278
0.99
0.01
4.1
3.3
46.02
39.51
u/l
0.69
120
1218
151
1503
1.01
0.01
6.1
4.8
40.73
38.76
mmol/mol
0.98
143
1416
17
165
1.03
0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
15.08
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
20.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
37.57
—
0
7
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
7.47
—
0
6
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
1722.29
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint F5_MODRET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MODRET | 6.615 [5.16, 8.48] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.1 |
During the follow-up period (1.1.1998 — 31.12.2019), 265 out of 1858 females with F5_MODRET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_MODRET | 3.444 [2.87, 4.13] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 284 out of 2621 males with F5_MODRET died.
Mortality risk
Mortality risk for people of age
years, who have F5_MODRET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.543% | 0.549% |
| 5 | 3.359% | 3.302% |
| 10 | 8.41% | 8.733% |
| 15 | 16.665% | 16.144% |
| 20 | 26.975% | 26.716% |
Relationships between endpoints
↥Index endpoint: F5_MODRET – Moderate mental retardation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data