Felty's syndrome: Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
198 |
4. Check minimum number of eventsNone |
198 |
5. Include endpointsNone |
198 |
6. Filter based on genotype QC (FinnGen only) |
192 |
Control definitions (FinnGen only)
- Control exclude
- RHEUMA_SEROPOS
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M05
- Name in latin
- Syndroma Felty
Similar endpoints
↥List of similar endpoints to
Felty syndrome
based on the number of shared cases.
Similar with more cases:
- Seropositive rheumatoid arthritis
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2047 | 1446 | 568 |
| Only index persons | 1398 | 1042 | 356 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.03 | 0.04 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.27 | 66.71 | 64.83 |
| Only index persons | 62.81 | 63.27 | 61.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 192 | 139 | 53 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | 59.45 | 58.62 | 61.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 198
- Matched controls
- 1980
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
170.4
269.5
172
74
M05.0
ICD-10 Finland
Felty syndrome
+∞
267.2
191
*
P01BA02
ATC
hydroxychloroquine; oral
66.6
200.2
133
59
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
1552.2
197.0
160
5
L04AX03
ATC
methotrexate; systemic
57.2
185.9
127
60
A07EC01
ATC
sulfasalazine; oral, rectal
50.3
165.6
112
50
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
111.5
145.2
76
11
L88
ICPC
Rheumatoid/seropositive arthritis
91.3
144.0
78
14
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
42.0
143.7
100
47
L01BA01
ATC
methotrexate; systemic
394.6
127.5
116
7
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
45.3
121.5
78
28
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
1832.0
109.3
96
*
L04AA13
ATC
[U] leflunomide
373.8
76.2
72
*
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
+∞
72.4
65
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
149.0
61.0
62
6
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
33.2
59.6
40
15
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
129.0
54.1
56
6
M01CB01
ATC
sodium aurothiomalate; parenteral
+∞
49.0
45
*
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
572.9
47.4
45
*
L04AB01
ATC
etanercept; parenteral
540.1
45.1
43
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
9.6
40.4
56
78
H02AB06
ATC
prednisolone; systemic
8.2
35.4
163
716
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
8.3
34.0
53
84
L04AB04
ATC
adalimumab; parenteral
78.6
30.0
33
5
M05BA04
ATC
alendronic acid; oral
5.8
25.0
56
126
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.6
23.8
132
601
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
8.7
23.2
32
43
H02AB07
ATC
prednisone; oral
5.1
23.0
62
163
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
246.1
22.1
22
*
L04AX01
ATC
azathioprine; systemic
19.5
21.9
33
20
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
67.8
21.4
24
*
L04AA01
ATC
[U] ciclosporin
47.4
21.0
25
6
R4120
NOMESCO Finland
Occupational therapy
7.3
20.5
33
53
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
6.8
20.1
35
61
M01CB03
ATC
auranofin; oral
221.2
19.9
20
*
ZX120
NOMESCO Finland
Intravenous
5.1
18.9
46
110
D06BB04
ATC
podophyllotoxin; topical
8.8
18.7
25
32
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
25.8
18.3
25
11
M01AH01
ATC
celecoxib; oral
3.8
17.1
70
247
NH3EA
NOMESCO Finland
Feet X-ray examination with load
44.1
16.7
20
5
M05BA07
ATC
risedronic acid; oral
7.6
16.6
25
37
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
33.3
16.5
21
7
H02AB04
ATC
methylprednisolone; systemic
4.0
16.4
58
184
NDG30
NOMESCO Finland
Fusion of wrist, total
65.6
16.0
18
*
L04AA17
ATC
[U] adalimumab
+∞
15.8
15
*
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
92.6
15.8
17
*
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
92.6
15.8
17
*
XX9XE
NOMESCO Finland
Other ultrasound examination
92.6
15.8
17
*
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
173.1
15.7
16
*
TNG10
NOMESCO Finland
Puncture of knee
49.2
15.3
18
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.6
15.2
69
258
L04AB05
ATC
certolizumab pegol; parenteral
+∞
14.8
14
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.2
14.7
46
133
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
21.2
14.6
21
11
7140B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]
80.9
13.8
15
*
9256
FHL
Synovectomy (knee 9311)
+∞
13.7
13
*
L04AB06
ATC
golimumab; parenteral
+∞
13.7
13
*
L01CB
ATC
Podophyllotoxin derivatives
+∞
13.7
13
*
M06
ICD-10 Finland
Other rheumatoid arthritis
+∞
13.7
13
*
NDL52
NOMESCO Finland
Tenosynovectomy of hand
43.3
13.4
16
*
J01FF01
ATC
clindamycin; systemic
3.1
12.9
78
343
M81.9
ICD-10 Finland
Osteoporosis, unspecified
5.4
12.8
27
56
L04AA11
ATC
[U] etanercept
+∞
12.6
12
*
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
+∞
12.6
12
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
17.8
11.9
18
11
NDG76
NOMESCO Finland
Fusion of DIP joint
32.2
11.8
15
5
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
20.5
11.8
17
9
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
20.5
11.8
17
9
NDB60
NOMESCO Finland
Prosthetic replacement of MCP joint of finger
+∞
11.6
11
*
L04AC07
ATC
tocilizumab; parenteral
+∞
11.6
11
*
L04AA24
ATC
abatacept; parenteral
127.1
11.6
12
*
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
8.5
10.7
23
30
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
63.5
10.7
12
*
N02AX02
ATC
tramadol; systemic, rectal
2.7
10.6
110
628
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
5.2
10.5
23
49
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
115.9
10.5
11
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
10.4
78
378
M05BX04
ATC
denosumab; parenteral
4.3
10.4
29
76
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
5.5
10.3
21
42
D70.89
ICD-10 Finland
Neutropenic splenomegaly
15.7
10.2
16
11
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
42.4
10.1
12
*
B01AB04
ATC
dalteparin; parenteral
5.1
10.0
22
47
9503
FHL
Tendon or tendon sheath cleansing surgery (tenosynovectomy)
57.9
9.7
11
*
7148X
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Other specified inflammatory polyarthropathies
104.8
9.5
10
*
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
10.3
9.5
18
19
M01AH02
ATC
rofecoxib; oral
3.1
9.2
45
172
1XC02, ,
NOMESCO Finland
38.6
9.1
11
*
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
5.3
9.0
19
39
NG1DA
NOMESCO Finland
X-ray of knees
11.5
9.0
16
15
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.7
8.9
31
95
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
4.6
8.9
22
52
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.8
8.9
21
48
ZXX01
NOMESCO Finland
Extent of proceudre, 1 unit
28.9
8.6
11
*
WX320
NOMESCO Finland
Spinalanesthesy
2.6
8.6
68
334
ZXA00
NOMESCO Finland
Right side
2.5
8.5
80
425
J01MA12
ATC
levofloxacin; systemic
2.7
8.5
57
257
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.6
8.5
31
98
RT271, ,
NOMESCO Finland
93.9
8.5
9
*
NDM99
NOMESCO Finland
Other operation on fascia, ganglion, synovial sheath or bursa of wrist or hand
93.9
8.5
9
*
TQW40
NOMESCO Finland
Remowal of suture of skin
3.9
8.5
26
73
NDB78
NOMESCO Finland
Prosthetic replacement of several of finger or metacarpal
+∞
8.4
8
*
M01CC01
ATC
penicillamine; oral
+∞
8.4
8
*
TNB10
NOMESCO Finland
Joint puncture, shoulder joint
+∞
8.4
8
*
M19.2
ICD-10 Finland
Other secondary arthrosis
15.3
8.3
13
9
L04AD01
ATC
ciclosporin; systemic
11.5
7.9
14
13
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
7.8
109
682
TND10
NOMESCO Finland
Joint puncture, wrist or finger joint
46.9
7.8
9
*
H02AB08
ATC
triamcinolone; systemic
46.9
7.8
9
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.8
7.7
45
188
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
12.5
7.7
13
11
NK4AT
NOMESCO Finland
Puncture of joint with ultrasound guidance not elsewher classified
19.3
7.7
11
6
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
10.7
7.7
14
14
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.2
7.6
34
122
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
4.7
7.6
18
41
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.4
7.5
29
95
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
14.1
7.5
12
9
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
83.1
7.5
8
*
ZXA05
NOMESCO Finland
Left side
2.4
7.4
72
384
M08.8
ICD-10 Finland
Other juvenile arthritis
+∞
7.3
7
*
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
+∞
7.3
7
*
3006
Kela drug reimbursment
Baricitinib
+∞
7.3
7
*
9527
FHL
Alloarthroplasty, implant or endoprosthesis
+∞
7.3
7
*
NDF10
NOMESCO Finland
Synovectomy of wrist
+∞
7.3
7
*
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
4.8
7.3
17
38
ZX140
NOMESCO Finland
Intra articular
31.3
7.2
9
*
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
31.3
7.2
9
*
NF1AA
NOMESCO Finland
Hip X-ray examination
3.2
7.0
30
105
M45
ICD-10 Finland
Ankylosing spondylitis
9.8
6.9
13
14
9272
FHL
Metatarsophalangeal joint resection
41.5
6.8
8
*
NK6PA
NOMESCO Finland
Measurement of bone density from one location with X-ray
41.5
6.8
8
*
M01AB55
ATC
diclofenac, combinations; oral
3.4
6.8
26
85
Z3231
NOMESCO Finland
Registered nurse
2.3
6.7
71
390
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.4
6.7
17
41
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
9.2
6.7
13
15
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
7.3
6.7
15
22
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.0
6.6
32
120
M05BA06
ATC
ibandronic acid; systemic
6.6
6.6
16
26
R50.9
ICD-10 Finland
Fever, unspecified
2.7
6.6
39
164
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
6.5
57
289
TNC11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in elbow joint
72.1
6.5
7
*
N02BA01
ATC
acetylsalicylic acid; systemic, rectal
72.1
6.5
7
*
71200
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Juvenile rheumatoid arthritis
72.1
6.5
7
*
NDG74
NOMESCO Finland
Fusion of first IP joint
72.1
6.5
7
*
5BA08, ,
NOMESCO Finland
72.1
6.5
7
*
M05BB03
ATC
alendronic acid and colecalciferol; oral
5.4
6.4
18
36
Z3226
NOMESCO Finland
Physiotherapist
2.4
6.4
51
248
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
7.4
6.3
14
20
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
6.1
6.3
16
28
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.4
6.3
24
78
9289
FHL
Other measure in this category
+∞
6.3
6
*
TNH10
NOMESCO Finland
Joint puncture, ankle joint or foot joint
+∞
6.3
6
*
L04AA37
ATC
[U] baricitinib
+∞
6.3
6
*
293
Kela drug reimbursment
Baricitinib
+∞
6.3
6
*
RT171, ,
NOMESCO Finland
+∞
6.3
6
*
NDG77
NOMESCO Finland
Other excision, reconstruction or fusion of joint of first finger
+∞
6.3
6
*
9531
FHL
Arthrodesis of the hand joint
+∞
6.3
6
*
M05.3
ICD-10 Finland
Rheumatoid arthritis with involvement of other organs and systems
+∞
6.3
6
*
7143C
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[POLYARTHRITIS JUVENILIS SERONEGATIVA]
+∞
6.3
6
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
27.6
6.3
8
*
ZZH31
NOMESCO Finland
Bone allograft, small pieces
27.6
6.3
8
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.0
6.2
18
48
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.1
6.1
111
747
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
33
27
14.47
34.13
2.3
1.2
—
—
—
0
0
28
39
8.20
19.61
1.7
1.6
0.01
0.04
iu/ml
—
8
9
30
24
14.52
17.84
3.5
1.7
8122.90
27061.38
e6/l
0.61
21
16
149
907
3.60
14.31
20.5
8.9
4.09
4.01
e9/l
0.18
143
784
55
235
2.86
9.17
1.3
1.3
104.35
2.16
u/ml
4.50
27
91
54
247
2.63
7.78
1.3
1.3
133.94
23.11
iu/ml
3.53
39
77
108
686
2.26
7.35
2.7
2.3
82.90
78.88
nmol/l
0.83
102
596
12
12
10.56
6.63
1.1
1.3
—
—
—
0
0
17
30
6.10
6.62
2.1
1.7
—
—
—
0
0
32
123
2.91
6.35
2.3
1.8
—
—
—
0
0
114
779
2.09
6.01
6.0
4.1
0.00
0.00
estimate
-0.00
30
156
112
780
2.00
5.39
8.4
5.5
0.00
0.00
estimate
-0.00
29
145
17
50
3.63
5.15
2.9
2.3
—
—
—
0
0
41
199
2.34
5.06
5.7
4.8
1.04
1.04
mmol/l
0.05
36
176
111
789
1.93
4.85
6.1
4.1
0.00
0.00
estimate
-0.00
28
139
8
7
11.84
4.83
1.8
2.4
—
—
—
0
0
115
837
1.89
4.57
9.5
6.3
1.21
1.22
mmol/l
0.58
102
713
49
270
2.08
4.40
2.6
1.9
—
—
—
0
0
19
69
2.94
4.15
11.4
4.9
1.55
1.41
%
0.49
19
64
46
253
2.07
4.14
4.2
3.2
0.81
0.80
mmol/l
0.34
41
236
12
26
4.84
4.13
1.3
1.1
—
—
—
0
0
132
1564
0.53
4.00
4.9
5.2
2.46
2.70
mmol/l
2.53
122
1408
37
191
2.15
3.91
1.7
1.8
—
—
—
0
0
13
34
4.02
3.77
1.0
1.2
—
—
—
0
0
13
34
4.02
3.77
1.0
1.2
—
—
—
0
0
103
765
1.72
3.48
7.0
5.4
1.21
1.22
mmol/l
0.78
97
687
104
784
1.69
3.26
12.5
14.0
1.30
1.22
inr
0.35
27
218
12
35
3.58
3.16
1.8
1.5
—
—
—
0
0
124
1467
0.59
3.14
5.8
6.1
38.69
40.31
mmol/mol
1.17
115
1348
35
192
2.00
3.14
1.7
1.9
—
—
—
0
0
129
1510
0.58
3.12
4.4
4.5
1.60
1.53
mmol/l
0.84
121
1358
8
16
5.16
3.08
1.4
1.4
—
—
—
0
0
7
12
6.00
3.04
5.3
5.8
—
—
—
0
0
9
21
4.44
3.03
1.3
1.6
—
—
—
0
0
98
737
1.65
3.03
7.0
4.2
33.34
35.31
g/l
2.31
90
683
61
406
1.73
2.98
2.9
2.0
3.61
3.24
mg/l
0.55
54
339
131
1522
0.59
2.97
4.5
4.6
4.53
4.65
mmol/l
0.79
122
1380
9
22
4.23
2.92
3.4
3.6
60.33
57.45
%
—
9
22
10
28
3.70
2.82
1.3
1.6
—
—
—
0
0
26
134
2.08
2.76
2.0
3.2
63.67
66.37
g/l
0.87
26
120
9
24
3.88
2.70
1.3
1.6
—
—
—
0
0
10
30
3.45
2.64
1.3
1.2
—
—
—
0
0
5
7
7.29
2.56
1.2
1.6
—
—
—
0
0
12
45
2.77
2.50
1.8
1.4
—
—
—
0
0
125
1450
0.63
2.49
4.2
4.1
1.33
1.27
mmol/l
0.41
114
1294
8
23
3.58
2.29
3.4
1.7
—
—
—
0
0
8
23
3.58
2.29
3.4
1.7
—
—
—
0
0
135
1529
0.63
2.25
4.4
4.9
5.71
6.01
mmol/l
2.51
124
1375
5
9
5.67
2.22
4.4
1.9
—
—
—
0
0
5
9
5.67
2.22
4.6
1.9
—
—
—
0
0
13
55
2.46
2.17
1.4
1.3
—
—
—
0
0
8
25
3.29
2.12
1.4
1.6
—
—
—
0
0
78
593
1.52
2.11
3.2
3.3
2.32
2.37
mmol/l
1.48
69
526
7
20
3.59
2.07
1.0
1.1
—
—
—
0
0
7
20
3.59
2.07
1.7
1.1
—
—
—
0
0
6
15
4.09
2.05
6.2
2.1
—
—
—
0
0
13
57
2.37
2.02
2.5
1.9
—
—
—
0
0
70
525
1.52
2.00
2.5
2.4
67.34
56.58
u/l
0.66
64
484
39
258
1.64
1.90
3.7
3.2
2.16
3.46
e6/l
0.66
24
129
11
46
2.47
1.89
2.0
1.5
—
—
—
0
0
6
17
3.60
1.85
6.2
2.0
—
—
—
0
0
5
12
4.24
1.83
1.2
1.1
—
—
—
0
0
7
23
3.12
1.81
1.6
1.3
—
—
—
0
0
25
148
1.79
1.81
3.0
2.2
0.21
0.21
g/l
0.03
25
135
26
159
1.73
1.69
4.8
3.6
2.57
2.36
mmol/l
0.12
21
133
14
69
2.11
1.69
1.5
2.2
—
—
—
0
0
5
14
3.63
1.62
4.4
2.1
—
—
—
0
0
5
14
3.63
1.62
4.4
2.1
—
—
—
0
0
5
14
3.63
1.62
4.4
2.1
—
—
—
0
0
47
339
1.51
1.59
1.2
1.2
0.70
0.97
u/ml
—
9
95
8
33
2.48
1.55
1.4
1.4
—
—
—
0
0
6
21
2.91
1.51
1.5
1.2
186.00
266.18
u/ml
—
6
11
81
654
1.40
1.51
4.0
2.7
268.29
115.48
ug/l
0.61
75
590
58
442
1.44
1.48
6.9
4.4
0.00
0.00
estimate
-0.00
28
144
9
40
2.31
1.42
4.9
1.7
—
—
—
0
0
17
97
1.82
1.40
2.1
1.9
—
—
—
0
0
9
41
2.25
1.39
3.0
1.6
—
—
—
0
0
34
238
1.52
1.32
2.7
2.4
20.84
21.16
%
0.04
26
201
12
63
1.96
1.25
4.4
2.0
—
—
—
0
0
8
37
2.21
1.23
1.8
1.3
—
—
—
0
0
42
312
1.44
1.22
4.8
3.6
534.20
80.78
ng/l
0.53
35
254
38
283
1.42
1.10
3.6
2.9
0.77
1.15
e6/l
0.82
23
151
13
214
0.58
1.09
9.6
8.1
—
—
—
0
0
12
67
1.84
1.07
1.5
2.1
9.83
10.00
g/l
0.06
12
62
16
98
1.69
1.07
4.0
2.9
0.08
0.28
e6/l
0.92
16
93
11
60
1.88
1.05
1.4
2.6
0.86
0.44
g/l
0.30
11
54
9
49
1.88
1.00
1.2
2.0
—
—
—
0
0
63
520
1.31
0.96
3.9
3.4
2000.80
1398.03
ng/l
0.59
55
445
73
616
1.29
0.94
7.2
4.3
—
—
—
0
0
6
27
2.26
0.94
1.0
1.4
—
—
—
0
0
136
1466
0.77
0.91
6.2
5.0
2.12
1.95
mu/l
0.94
129
1322
46
368
1.33
0.87
2.4
1.7
1.55
1.34
mg/l
0.32
41
281
49
396
1.32
0.86
2.5
3.0
350.80
9052.43
umol/l
2.72
44
332
6
31
1.96
0.85
3.2
2.5
107.33
106.06
mmol/l
—
6
31
6
33
1.84
0.79
6.0
1.7
—
—
—
0
0
0
25
0.00
0.79
0.0
1.4
—
—
—
0
0
165
1561
1.34
0.79
37.6
15.1
19.46
24.28
mg/l
1.74
155
1229
6
34
1.79
0.77
1.0
1.5
—
—
—
0
0
6
106
0.55
0.75
1.0
1.8
—
—
—
0
0
81
710
1.24
0.74
2.1
2.1
102.56
95.81
pmol/l
0.47
40
331
75
659
1.22
0.66
5.1
4.2
44.89
32.58
ng/l
0.51
52
492
25
191
1.35
0.65
10.0
6.1
0.65
1.31
mmol/l
0.44
20
153
54
461
1.24
0.62
4.4
3.2
0.33
0.40
e6/l
0.15
43
335
19
142
1.37
0.57
2.4
3.9
1.26
1.23
mmol/l
1.25
19
126
22
169
1.34
0.56
3.0
3.5
—
—
—
0
0
45
381
1.23
0.56
2.1
1.8
430.22
432.55
pmol/l
0.02
40
311
44
514
0.81
0.54
4.1
3.6
9.00
6.37
mg/mmol
0.30
33
303
27
216
1.29
0.53
3.1
6.1
105.11
103.98
mmol/l
0.87
27
216
51
441
1.21
0.52
2.0
1.6
21.36
21.33
nmol/l
0.00
45
365
164
1696
0.81
0.48
47.8
22.3
38.88
39.55
%
0.70
148
1590
67
600
1.18
0.46
4.1
3.2
—
—
—
0
0
12
86
1.42
0.45
2.3
5.5
25.12
24.96
mmol/l
0.04
12
86
102
946
1.16
0.45
3.9
2.9
53.17
48.16
u/l
0.19
93
863
27
221
1.26
0.45
1.5
1.4
—
—
—
0
0
41
352
1.21
0.45
1.8
1.8
981.21
1236.92
nmol/l
1.26
27
252
116
1231
0.86
0.44
5.6
4.1
15.52
15.13
pmol/l
0.85
109
1101
15
113
1.35
0.44
14.0
6.6
21.51
24.54
mmol/l
1.26
15
108
8
56
1.45
0.43
1.3
1.1
—
—
—
0
0
8
57
1.42
0.42
1.3
1.1
—
—
—
0
0
80
732
1.16
0.42
3.9
2.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
14
106
1.35
0.40
1.6
1.4
—
—
—
0
0
11
80
1.40
0.39
1.2
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
3.9
—
99.25
—
0
19
6
89
0.66
0.33
2.0
1.7
—
—
—
0
0
11
85
1.31
0.28
2.2
2.4
0.73
0.65
%
0.42
11
85
90
848
1.11
0.28
3.3
2.7
—
—
—
0
0
11
86
1.30
0.26
2.2
2.4
1.23
1.10
%
0.19
11
86
6
81
0.73
0.24
1.8
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
4.4
—
—
—
0
0
23
202
1.16
0.21
4.2
3.7
6.74
10.39
ug/l
0.45
18
172
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
33
362
0.89
0.19
2.8
2.8
2.48
2.47
mmol/l
0.38
27
325
17
147
1.17
0.18
3.1
5.2
1.67
1.45
mmol/l
0.19
17
141
22
247
0.88
0.18
4.6
4.7
18.80
22.43
%
0.68
13
119
161
1639
0.91
0.17
35.9
18.0
74.08
76.31
umol/l
0.52
161
1639
9
108
0.83
0.13
4.7
6.7
1.33
1.45
%
—
9
108
9
108
0.83
0.13
4.7
6.7
0.56
0.72
%
—
9
108
39
406
0.95
0.07
1.6
1.6
1.61
1.32
mmol/l
0.73
34
337
144
1455
0.96
0.05
24.7
14.8
78.73
76.16
ml/min/173m2
0.67
124
1184
38
371
1.03
0.02
4.3
2.4
—
—
—
0
0
10
94
1.07
0.01
1.5
1.1
377.00
147.17
iu/ml
—
5
37
25
249
1.00
0.00
2.5
1.9
30.08
29.18
s
0.42
25
238
16
157
1.02
0.00
1.8
2.5
24.09
30.17
u/l
0.67
11
129
27
265
1.02
0.00
1.9
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
6.6
—
238.50
—
0
8
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
7.35
—
0
5
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.0
—
139.17
—
0
6
7
75
0.93
-0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
-0.00
0.0
2.8
—
116.00
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint FELTY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FELTY | 2.656 [2.3, 3.06] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.553 |
During the follow-up period (1.1.1998 — 31.12.2019), 536 out of 1102 females with FELTY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FELTY | 2.379 [1.86, 3.04] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 414 males with FELTY died.
Mortality risk
Mortality risk for people of age
years, who have FELTY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.245% | 0.413% |
| 5 | 1.675% | 2.536% |
| 10 | 4.164% | 6.464% |
| 15 | 7.829% | 11.817% |
| 20 | 13.78% | 19.08% |
Relationships between endpoints
↥Index endpoint: FELTY – Felty syndrome
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data