Felty's syndrome: Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
197 |
4. Check minimum number of eventsNone |
197 |
5. Include endpointsNone |
197 |
6. Filter based on genotype QC (FinnGen only) |
197 |
Control definitions (FinnGen only)
- Control exclude
- RHEUMA_SEROPOS
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M05
- Name in latin
- Syndroma Felty
Similar endpoints
↥List of similar endpoints to
Felty syndrome
based on the number of shared cases.
Similar with more cases:
- Seropositive rheumatoid arthritis
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2047 | 1446 | 568 |
| Only index persons | 1398 | 1042 | 356 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.03 | 0.04 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.27 | 66.71 | 64.83 |
| Only index persons | 62.81 | 63.27 | 61.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 197 | 142 | 55 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | 59.43 | 58.58 | 61.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 174
- Matched controls
- 1739
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M05.0
ICD-10 Finland
Felty syndrome
+∞
235.1
168
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2359.5
175.9
141
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
135.6
136.7
150
76
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
197.4
104.7
101
12
P01BA02
ATC
hydroxychloroquine; oral
73.1
101.6
116
46
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
97.2
84
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
56.7
92.0
111
52
A07EC01
ATC
sulfasalazine; oral, rectal
58.3
80.8
95
35
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
+∞
68.3
61
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
36.6
64.7
85
44
L04AA13
ATC
leflunomide; oral
162.8
62.8
63
6
L88
ICPC
Rheumatoid/seropositive arthritis
70.3
61.6
69
16
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
95.2
58.1
62
10
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
155.0
53.4
54
5
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
29.6
48.1
66
35
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
135.1
47.7
49
5
M01CB01
ATC
sodium aurothiomalate; parenteral
274.6
43.0
42
*
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
171.8
39.6
40
*
L04AB01
ATC
etanercept; parenteral
217.4
35.1
35
*
H02AB06
ATC
prednisolone; systemic
8.1
32.0
142
614
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
29.9
27.0
36
15
L04AB04
ATC
adalimumab; parenteral
82.7
25.6
28
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
10.2
22.2
46
59
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
10.0
21.0
44
57
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
118.7
20.0
21
*
L04AA01
ATC
[U] ciclosporin; systemic
36.1
19.9
25
8
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
62.5
19.4
22
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.5
19.3
114
519
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
14.2
18.2
31
26
L04AX01
ATC
azathioprine; systemic
12.1
17.9
33
33
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
199.5
17.9
18
*
M05BA04
ATC
alendronic acid; oral
6.0
16.3
49
107
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
+∞
15.9
15
*
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
93.7
15.9
17
*
NDG30
NOMESCO Finland
Fusion of wrist, total
93.7
15.9
17
*
M01CB03
ATC
auranofin; oral
62.3
15.1
17
*
L04AA17
ATC
[U] adalimumab; parenteral
+∞
14.8
14
*
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
163.1
14.7
15
*
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
30.2
14.6
19
7
H02AB07
ATC
prednisone; oral
4.8
14.2
53
146
NDL52
NOMESCO Finland
Tenosynovectomy of hand
81.3
13.8
15
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
24.9
13.2
18
8
D06BB04
ATC
podophyllotoxin; topical
11.4
13.0
24
24
M01AH01
ATC
celecoxib; oral (coxibs)
4.0
12.9
60
202
NDG76
NOMESCO Finland
Fusion of DIP joint
75.5
12.8
14
*
7140B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]
75.5
12.8
14
*
L01CB
ATC
Podophyllotoxin derivatives
+∞
12.7
12
*
L04AB05
ATC
certolizumab pegol; parenteral
+∞
12.7
12
*
XX9XE
NOMESCO Finland
Other ultrasound examination
40.7
12.4
15
*
ZX120
NOMESCO Finland
Intravenous
5.0
12.4
43
108
NH3EA
NOMESCO Finland
Feet X-ray examination with load
19.9
12.3
18
10
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
29.1
12.3
16
6
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
25.0
11.8
16
7
9256
FHL
Synovectomy (knee 9311)
+∞
11.6
11
*
M06
ICD-10 Finland
Other rheumatoid arthritis
+∞
11.6
11
*
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
128.1
11.6
12
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.6
11.5
61
227
R4120
NOMESCO Finland
Occupational therapy
6.7
11.0
28
48
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
17.5
10.6
16
10
ZXA00
NOMESCO Finland
Right side
3.1
10.6
75
339
9503
FHL
Tendon or tendon sheath cleansing surgery (tenosynovectomy)
116.8
10.5
11
*
H02AB04
ATC
methylprednisolone; systemic
3.8
10.5
50
168
L04AA11
ATC
[U] etanercept; parenteral
+∞
10.5
10
*
L04AC07
ATC
tocilizumab; parenteral
+∞
10.5
10
*
D70.89
ICD-10 Finland
Neutropenic splenomegaly
34.9
10.5
13
*
TNG10
NOMESCO Finland
Puncture of knee
34.9
10.5
13
*
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
6.0
10.4
29
56
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
18.1
10.1
15
9
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
58.3
9.8
11
*
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
8.4
9.8
21
28
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
32.0
9.5
12
*
L04AB06
ATC
golimumab; parenteral
105.5
9.5
10
*
M05BA07
ATC
risedronic acid; oral
7.0
9.5
23
37
NDB60
NOMESCO Finland
Prosthetic replacement of MCP joint of finger
+∞
9.5
9
*
L04AA24
ATC
abatacept; parenteral
+∞
9.5
9
*
7148X
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Other specified inflammatory polyarthropathies
+∞
9.5
9
*
J01FF01
ATC
clindamycin; systemic
3.0
9.3
67
300
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
38.9
9.1
11
*
L04AD01
ATC
ciclosporin; systemic
25.6
9.0
12
5
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.0
9.0
29
67
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
8.6
8.6
18
23
M01CC01
ATC
penicillamine; oral
+∞
8.4
8
*
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
+∞
8.4
8
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.6
8.3
29
73
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
12.6
8.2
14
12
ZXX01
NOMESCO Finland
Extent of proceudre, 1 unit
35.1
8.2
10
*
1XC02
NOMESCO Finland
NA
35.1
8.2
10
*
NG1DA
NOMESCO Finland
X-ray of knees
13.9
8.0
13
10
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
7.6
8.0
18
26
N02AX02
ATC
tramadol; systemic, rectal
2.5
7.8
91
531
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
47.1
7.8
9
*
NDM99
NOMESCO Finland
Other operation on fascia, ganglion, synovial sheath or bursa of wrist or hand
47.1
7.8
9
*
NK4AT
NOMESCO Finland
Puncture of joint with ultrasound guidance not elsewher classified
47.1
7.8
9
*
WX204
NOMESCO Finland
Axillary plexus blockaced
10.8
7.7
14
14
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
26.3
7.7
10
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.5
7.6
36
119
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.5
7.6
96
581
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
83.5
7.5
8
*
TND10
NOMESCO Finland
Joint puncture, wrist or finger joint
83.5
7.5
8
*
ZZH31
NOMESCO Finland
Bone allograft, small pieces
83.5
7.5
8
*
ZXA05
NOMESCO Finland
Left side
2.6
7.4
66
330
NDB78
NOMESCO Finland
Prosthetic replacement of several of finger or metacarpal
+∞
7.3
7
*
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
+∞
7.3
7
*
NDF10
NOMESCO Finland
Synovectomy of wrist
+∞
7.3
7
*
TNC11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in elbow joint
+∞
7.3
7
*
71200
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Juvenile rheumatoid arthritis
+∞
7.3
7
*
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
31.4
7.2
9
*
ZX140
NOMESCO Finland
Intra articular
31.4
7.2
9
*
WX120
NOMESCO Finland
Intravenous local anesthesy of arm
31.4
7.2
9
*
WX320
NOMESCO Finland
Spinalanesthesy
2.7
7.1
56
259
Z3231
NOMESCO Finland
Registered nurse
2.5
7.0
64
324
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
9.9
6.9
13
14
M81.9
ICD-10 Finland
Osteoporosis, unspecified
5.0
6.9
21
46
TQW40
NOMESCO Finland
Remowal of suture of skin
4.4
6.8
24
61
H02AB08
ATC
triamcinolone; systemic
23.6
6.7
9
*
J01MA02
ATC
ciprofloxacin; systemic
2.3
6.7
86
511
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.4
6.7
33
113
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.0
6.6
40
156
J01MA12
ATC
levofloxacin; systemic
2.8
6.6
47
205
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.9
6.5
26
75
P01BA01
ATC
chloroquine; systemic
72.4
6.5
7
*
TNB10
NOMESCO Finland
Joint puncture, shoulder joint
72.4
6.5
7
*
M08.8
ICD-10 Finland
Other juvenile arthritis
72.4
6.5
7
*
RT271
NOMESCO Finland
NA
72.4
6.5
7
*
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
11.6
6.4
11
10
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
18.9
6.3
9
5
3006
Kela drug reimbursment
Baricitinib
+∞
6.3
6
*
NDG74
NOMESCO Finland
Fusion of first IP joint
+∞
6.3
6
*
7143C
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[POLYARTHRITIS JUVENILIS SERONEGATIVA]
+∞
6.3
6
*
M05.3
ICD-10 Finland
Rheumatoid arthritis with involvement of other organs and systems
+∞
6.3
6
*
9527
FHL
Alloarthroplasty, implant or endoprosthesis
+∞
6.3
6
*
NCM20
NOMESCO Finland
Excision of synovial ganglion of elbow or forearm
+∞
6.3
6
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
6.1
89
555
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.5
6.1
28
91
M01AH02
ATC
rofecoxib; oral
2.9
6.1
40
164
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
5.8
6.0
16
30
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
5.8
6.0
16
30
Mortality – FinRegistry
↥Association
Association between endpoint FELTY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FELTY | 2.656 [2.3, 3.06] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.553 |
During the follow-up period (1.1.1998 — 31.12.2019), 536 out of 1102 females with FELTY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FELTY | 2.379 [1.86, 3.04] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 414 males with FELTY died.
Mortality risk
Mortality risk for people of age
years, who have FELTY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.245% | 0.413% |
| 5 | 1.675% | 2.536% |
| 10 | 4.164% | 6.464% |
| 15 | 7.829% | 11.817% |
| 20 | 13.78% | 19.08% |
Relationships between endpoints
↥Index endpoint: FELTY – Felty syndrome
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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