neurodegenerative disease: A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function.
Senile degeneration of the brain, not elsewhere classified
DOID EFO Endpoint Browser PheWeb
G6_DEGENSEN
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
150 |
4. Check minimum number of eventsNone |
150 |
5. Include endpointsNone |
150 |
6. Filter based on genotype QC (FinnGen only) |
150 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEURODEG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF6
- Parent code in ICD-10
- G31
- Name in latin
- Degeneratio cerebri senilis non alibi classificata
Similar endpoints
↥List of similar endpoints to
Senile degeneration of the brain, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Degenerative diseases of the nervous system
- Other degenerative diseases of the nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3797 | 1926 | 1743 |
| Only index persons | 1467 | 804 | 663 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.05 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 75.25 | 76.87 | 73.64 |
| Only index persons | 76.36 | 78.22 | 74.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 150 | 54 | 96 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 73.32 | 74.13 | 72.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 138
- Matched controls
- 1379
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G31.1
ICD-10 Finland
Senile degeneration of brain, not elsewhere classified
+∞
139.1
109
*
G30.1
ICD-10 Finland
Alzheimer disease with late onset
38.8
26.5
33
11
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
43.8
25.6
31
9
N06DX01
ATC
memantine; oral
17.0
22.9
37
29
3312X
ICD-9 Finland
Other cerebral degenerations, Senile degeneration of brain
+∞
22.5
21
*
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
245.2
21.2
21
*
N06DA02
ATC
donepezil; oral
15.6
19.3
32
26
F03
ICD-10 Finland
Unspecified dementia
9.3
19.3
43
64
N05AX08
ATC
risperidone; systemic
8.3
15.5
36
56
G31.0
ICD-10 Finland
Circumscribed brain atrophy
154.4
13.7
14
*
N06DA03
ATC
rivastigmine; oral, transdermal
15.7
11.3
18
13
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
+∞
10.5
10
*
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
+∞
9.5
9
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
5.0
8.8
29
70
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
29.6
8.6
11
*
N05AH04
ATC
quetiapine; oral
4.7
8.6
30
77
P20
ICPC
Memory disturbance
3.6
7.1
33
110
G30.8
ICD-10 Finland
Other Alzheimer disease
17.8
6.8
10
6
F0019, G301
ICD-10 Finland
NA
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
15
39
4.16
5.40
1.3
1.3
—
—
—
0
0
22
84
2.90
4.46
1.7
1.6
—
—
—
0
0
41
233
2.05
3.47
2.6
1.8
1206.2
1212.2
nmol/l
0.01
31
185
62
794
0.62
2.09
7.9
6.9
42.6
42.3
mmol/mol
0.08
55
725
63
797
0.64
1.95
4.3
4.8
1.4
1.4
mmol/l
0.16
52
701
61
777
0.64
1.94
4.2
4.3
1.3
1.2
mmol/l
0.38
49
680
64
803
0.64
1.87
4.2
4.8
4.5
4.3
mmol/l
0.71
51
716
68
833
0.66
1.70
5.1
5.1
5.7
6.2
mmol/l
1.52
62
729
68
831
0.66
1.66
4.7
5.4
2.7
2.5
mmol/l
1.30
57
731
66
807
0.67
1.58
22.6
18.4
68.7
69.0
ml/min/173m2
0.04
53
662
11
52
2.20
1.48
2.3
2.3
9.2
6.9
ug/l
0.08
11
43
76
887
0.71
1.28
29.0
22.3
98.6
88.4
umol/l
0.46
76
887
5
20
2.55
1.16
2.2
1.5
—
—
—
0
0
5
21
2.43
1.10
1.6
2.9
—
—
—
0
0
22
310
0.66
1.00
5.2
4.0
10.7
12.2
mg/mmol
0.08
16
208
7
36
1.99
0.98
1.1
1.6
—
—
—
0
0
13
78
1.73
0.95
1.5
1.4
—
—
—
0
0
18
121
1.55
0.87
1.8
1.8
—
—
—
0
0
26
344
0.70
0.85
4.1
4.6
20.9
21.7
%
0.12
14
188
41
503
0.74
0.84
4.8
8.4
5.9
4.4
e9/l
1.90
36
428
17
243
0.66
0.83
2.5
3.3
0.7
0.8
ug/l
0.07
11
166
25
184
1.43
0.80
2.8
2.3
10.8
11.9
umol/l
0.35
20
164
51
425
1.30
0.76
2.3
2.1
91.8
91.9
pmol/l
0.00
23
215
24
179
1.41
0.72
1.8
1.9
—
—
—
0
0
23
171
1.41
0.71
2.7
2.3
2.2
2.3
g/l
0.07
18
151
77
856
0.79
0.70
28.4
19.0
33.2
27.9
mg/l
0.54
65
732
7
44
1.62
0.66
1.6
1.8
—
—
—
0
0
5
30
1.69
0.62
1.2
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
17
124
1.42
0.58
1.9
1.9
—
—
—
0
0
31
252
1.29
0.55
1.6
1.6
22.9
20.9
nmol/l
0.27
25
197
68
754
0.82
0.55
5.9
4.5
2.1
2.1
mu/l
0.10
58
640
9
62
1.48
0.54
3.1
5.5
21.8
24.3
mmol/l
—
9
62
37
435
0.80
0.52
6.1
5.5
3.6
3.2
ug/l
0.11
32
369
40
339
1.24
0.51
2.8
2.8
2.3
2.3
mmol/l
0.05
32
289
54
473
1.22
0.51
3.6
3.0
48.5
59.3
u/l
0.66
46
429
35
292
1.26
0.51
2.8
2.1
2.7
3.3
mg/l
0.87
28
253
7
48
1.48
0.47
1.6
2.0
—
—
—
0
0
0
16
0.00
0.41
0.0
5.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
9
68
1.34
0.38
1.9
1.8
—
—
—
0
0
66
717
0.86
0.38
7.4
7.1
78.2
81.7
u/l
0.40
58
667
20
163
1.26
0.36
3.0
2.3
28.4
20.8
%
0.58
12
144
55
502
1.15
0.31
8.7
6.1
1.2
1.2
mmol/l
0.25
46
412
9
73
1.25
0.26
3.2
2.9
0.0
0.4
e6/l
—
9
73
26
228
1.17
0.24
2.9
2.3
—
—
—
0
0
49
451
1.13
0.24
5.9
4.3
0.0
0.0
estimate
—
10
97
29
257
1.16
0.24
2.3
1.8
550.8
442.5
pmol/l
0.47
23
219
0
11
0.00
0.21
0.0
1.3
—
11.4
—
0
11
0
12
0.00
0.21
0.0
1.8
—
15.6
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
327.6
—
0
13
34
370
0.89
0.18
2.4
2.3
87.4
77.1
nmol/l
0.80
28
314
49
458
1.10
0.18
6.1
4.3
0.0
0.0
estimate
—
10
90
49
458
1.10
0.18
8.0
5.8
1.2
1.2
mmol/l
0.20
43
404
24
265
0.89
0.16
7.0
4.3
0.0
0.0
estimate
—
7
91
40
373
1.10
0.15
5.5
3.5
—
—
—
0
0
7
88
0.78
0.15
7.6
3.8
1.2
1.2
mmol/l
—
7
78
31
286
1.11
0.14
4.9
3.4
1.0
0.5
e6/l
0.34
26
219
48
453
1.09
0.14
8.5
5.9
0.0
0.0
estimate
—
10
94
46
436
1.08
0.12
6.0
3.9
—
—
—
0
0
38
358
1.08
0.12
7.0
4.6
—
—
—
0
0
38
359
1.08
0.11
3.6
2.6
171.7
140.1
ug/l
0.41
31
315
59
611
0.94
0.10
4.4
3.5
14.7
15.1
pmol/l
0.39
50
521
62
637
0.95
0.07
4.2
4.4
15.5
15.9
mm/h
0.06
54
573
47
455
1.05
0.06
5.7
4.7
41.1
66.9
ng/l
1.01
39
359
14
129
1.09
0.06
4.0
4.8
31.6
32.0
%
—
9
80
21
203
1.04
0.01
2.8
2.7
2.5
2.5
mmol/l
0.01
15
179
10
94
1.07
0.00
2.8
3.1
114.5
352.1
ng/l
—
10
83
39
385
1.02
0.00
2.5
2.2
—
—
—
0
0
17
170
1.00
0.00
2.5
2.8
1.9
1.0
e6/l
0.20
11
96
12
125
0.96
0.00
9.9
9.5
—
—
—
0
0
17
167
1.02
0.00
3.1
3.0
0.9
2.0
e6/l
0.73
11
94
12
115
1.05
0.00
4.5
4.0
—
—
—
0
0
0
6
0.00
0.00
0.0
7.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
100.3
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
1.3
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
98.5
—
0
8
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
6
66
0.90
0.00
1.3
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_DEGENSEN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DEGENSEN | 2.462 [2.03, 2.98] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.078 |
During the follow-up period (1.1.1998 — 31.12.2019), 693 out of 897 females with G6_DEGENSEN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DEGENSEN | 2.829 [2.17, 3.68] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 543 out of 705 males with G6_DEGENSEN died.
Mortality risk
Mortality risk for people of age
years, who have G6_DEGENSEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.186% | 0.6% |
| 5 | 1.292% | 3.795% |
| 10 | 3.155% | 8.592% |
| 15 | 6.112% | 15.646% |
| 20 | 10.464% | 25.722% |
Relationships between endpoints
↥Index endpoint: G6_DEGENSEN – Senile degeneration of the brain, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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