Pneumoconiosis due to dust containing silica

J10_SILICAPNEUMOC

silicosis: Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20years) to low amounts of silica dust. Simple chronic silicosismay causepeople to have difficulty breathing. Accelerated silicosis occurs after 5 to 15 yearsof exposure of higher levels of silica.Swelling of the lungsand other symptoms occur faster in this type of silicosis than in the simple chronic form. Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica.The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months. People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J62 Hospital discharge: ICD-9 — 502 Hospital discharge: ICD-8 — 5150 Cause of death: ICD-10 — J62 Cause of death: ICD-9 — 502 Cause of death: ICD-8 — 5150 2 out of 7 registries used, show all original rules.	129
4. Check minimum number of events None	129
5. Include endpoints None	129
6. Filter based on genotype QC (FinnGen only)	124

Control definitions (FinnGen only)

Control exclude: J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: J60-J70
Name in latin: Silicosis

NAME	J10_SILICAPNEUMOC
CONTROL_EXCLUDE	J10_EXTERLUNG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J62
HD_ICD_9	502
HD_ICD_8	5150
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J62
COD_ICD_9	502
COD_ICD_8	5150
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Pneumoconiosis due to dust containing silica based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1139	103	997
Only index persons	595	70	525
Unadjusted period prevalence (%)
Whole population	0.03	0.00	0.03
Only index persons	0.02	0.00	0.02
Median age at first event (years)
Whole population	64.26	62.16	64.36
Only index persons	62.00	51.82	63.36

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	124	11	113
Unadjusted period prevalence (%)	0.05	0.00	0.05
Median age at first event (years)	64.12	41.77	66.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
129: Matched controls
1290

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

J62.8

ICD-10 Finland

Pneumoconiosis due to other dust containing silica

+∞

92.0

J62.0

ICD-10 Finland

Pneumoconiosis due to talc dust

+∞

57.7

R91

ICD-10 Finland

Abnormal findings on diagnostic imaging of lung

10.2

39.0

114

UGC12

NOMESCO Finland

Flexible bronchoscopy

8.4

26.9

J92.0

ICD-10 Finland

Pleural plaque with presence of asbestos

11.9

24.1

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

8.6

21.0

J62

ICD-10 Finland

Pneumoconiosis due to dust containing silica

+∞

13.8

51500

ICD-8 Finland

Pneumoconiosis due to silica and silicates, Silicosis

+∞

12.7

J61

ICD-10 Finland

Pneumoconiosis due to asbestos and other mineral fibres

131.2

11.6

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

6.1

11.5

J44.8

ICD-10 Finland

Other specified chronic obstructive pulmonary disease

3.7

10.7

162

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.5

10.7

466

5020A

ICD-9 Finland

Pneumoconiosis due to other silica or silicates[SILICOSIS]

+∞

10.6

Z57.2

ICD-10 Finland

Occupational exposure to dust

32.8

9.6

J45.1

ICD-10 Finland

Nonallergic asthma

5.3

9.2

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

10.4

8.0

H02AB06

ATC

prednisolone; systemic

2.9

7.7

469

R03BB04

ATC

tiotropium bromide; inhalant

3.2

7.3

128

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

2.9

6.9

177

J45.9

ICD-10 Finland

Asthma, unspecified

3.1

6.8

127

TGC00

NOMESCO Finland

Bronchial lavation

7.2

6.6

GD1AD

NOMESCO Finland

Thorax CT examination

5.6

6.5

J44.0

ICD-10 Finland

Chronic obstructive pulmonary disease with acute lower respiratory infection

3.9

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

6.63

13.46

2.5

2.7

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

7.49

8.26

2.3

1.8

49.89

42.49

u/l

0.50

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

7.64

4.75

1.1

1.2

—

(3042631) Mycobacterium sp identified in Specimen

6.36

3.89

2.6

2.7

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

5.60

3.58

1.4

1.5

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

6.01

3.39

1.6

1.1

—

(3023419) Bacteria identified in Sputum by Culture

5.25

3.10

3.8

2.4

—

(3037522) Nuclear Ab [Titer] in Serum

2.39

2.97

1.1

1.4

2626.67

463.16

titre

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

4.32

2.94

1.6

1.5

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

5.62

2.91

1.9

1.5

—

(3044927) Protein electrophoresis panel - Urine

6.92

2.90

1.0

1.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

432

1.84

2.89

8.9

6.5

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

4.12

2.83

1.4

1.5

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

6.23

2.73

1.2

1.8

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

6.23

2.73

1.2

1.8

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

6.23

2.73

1.2

1.8

—

(4200892) Spirometry reversibility

2.46

2.64

1.4

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

4.87

2.63

1.7

1.5

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

4.87

2.63

1.7

1.5

—

(3019060) Gas panel - Arterial blood

2.39

2.62

4.8

2.9

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

5.66

2.57

1.2

1.6

—

(3001604) Monocytes [#/volume] in Blood

454

1.76

2.53

6.1

5.7

0.69

0.62

e9/l

0.83

387

(3006315) Basophils [#/volume] in Blood

456

1.75

2.48

6.1

5.7

0.04

e9/l

0.71

391

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

5.18

2.43

1.2

1.6

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

4.29

2.39

1.7

1.5

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

6.44

2.39

1.2

1.5

2.01

0.58

g/l

—

(3013115) Eosinophils [#/volume] in Blood

472

1.71

2.31

8.8

5.8

0.19

0.21

e9/l

0.17

411

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.64

2.31

2.1

1.8

—

(3019198) Lymphocytes [#/volume] in Blood

466

1.69

2.23

6.1

5.8

1.73

1.87

e9/l

0.40

412

(1616796) Gas panel - Central venous blood

3.48

2.22

2.1

4.0

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

449

1.68

2.19

5.9

5.3

1.20

1.21

mmol/l

0.62

393

(3030905) Polymorphonuclear cells [#/volume] in Blood

4.44

2.17

1.8

2.9

5.11

4.38

e9/l

—

(3023368) Bacteria identified in Blood by Culture

323

1.72

2.17

4.9

4.3

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

4.14

2.06

1.2

1.7

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

4.14

2.06

1.2

1.7

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

3.88

1.96

1.8

3.1

59.33

58.56

—

(3042936) Bacteria identified in Isolate by Culture

156

1.83

1.87

1.8

1.9

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

4.29

1.84

1.0

1.1

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

4.29

1.84

1.0

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

175

1.77

2.2

1.8

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.99

1.77

1.2

1.4

1.16

14.56

u/ml

—

(3022313) Gas panel - Capillary blood

2.18

1.66

3.7

2.6

—

(3018418) pH of Serum or Plasma

281

1.61

1.64

3.8

3.9

7.40

—

(3019225) pH of Specimen

100

1.93

1.63

5.0

3.4

—

(3023199) Leukocytes [#/volume] in Pleural fluid

3.67

1.63

1.2

1.4

4313.40

2742.67

e6/l

—

(3020891) Body temperature

2.43

1.63

5.2

4.7

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.81

1.45

1.5

1.1

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

3.21

1.45

1.0

1.1

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

374

1.50

1.37

3.8

3.5

1486.92

1793.87

ng/l

0.35

323

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

1.35

0.0

7.0

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

2.00

1.27

2.2

3.3

63.67

54.64

ml/min/173m2

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.69

1.22

1.4

1.3

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.69

1.22

1.4

1.3

—

(4035726) Immunohistochemistry procedure

1.87

1.22

1.6

1.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

439

1.44

1.20

4.6

39.73

50.25

ng/l

0.42

348

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

1.18

0.0

2.0

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

527

1.43

1.17

10.7

8.6

4.62

4.25

e9/l

0.65

446

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

499

1.42

1.15

6.6

5.7

1.20

1.21

mmol/l

0.75

414

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.01

1.11

2.3

2.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.87

1.09

2.2

1.9

—

(3019309) Folate [Moles/volume] in Red Blood Cells

234

1.49

1.08

2.0

1.8

1080.24

1192.96

nmol/l

0.30

177

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.18

1.07

1.6

1.5

—

(3022145) Colonoscopy Study observation

1.71

1.02

1.3

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

2.06

1.01

1.7

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

125

1.61

1.01

2.2

1.8

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.99

0.0

1.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.99

0.0

1.8

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

857

0.72

0.98

4.9

5.3

2.32

2.48

mmol/l

1.11

769

(40760888) Immunoglobulin light chains.free panel - Serum

2.20

0.93

4.2

2.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.68

0.92

1.9

2.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

106

1.58

0.83

7.1

9.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.86

0.80

1.8

1.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

806

0.76

0.78

4.1

4.3

1.19

1.28

mmol/l

0.64

714

(3000492) Spirometry study

1.66

0.78

1.4

1.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.70

0.78

1.7

1.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

824

0.76

0.77

4.4

4.7

1.23

1.33

mmol/l

2.17

733

(3041096) Erythrocytes [Presence] in Urine by Automated

260

0.68

0.76

3.0

3.9

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.65

0.74

1.4

—

(3049717) Cytology report of Urine Cyto stain

1.65

0.74

2.0

2.5

—

(3025941) Bacteria identified in Stool by Culture

1.84

0.74

1.6

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

119

1.49

0.71

4.5

3.6

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.75

0.71

2.0

1.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.89

0.69

1.0

1.7

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.89

0.69

2.8

1.4

1.05

1.12

g/l

—

(3022217) INR in Platelet poor plasma by Coagulation assay

540

1.29

0.69

17.3

18.6

1.38

1.40

inr

0.03

152

(3020682) Albumin/Creatinine [Ratio] in Urine

309

0.73

0.68

3.5

3.8

4.27

12.57

mg/mmol

1.74

201

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

1.66

0.68

5.3

2.8

—

1.56

—

(3009542) Hematocrit [Volume Fraction] of Blood

950

0.77

0.65

34.8

25.0

40.75

39.97

0.65

886

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

349

0.75

0.64

3.8

4.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

123

1.44

0.61

2.1

1.7

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

831

0.79

0.60

4.3

4.8

3.96

4.25

mmol/l

2.42

753

(1761868) Lipid panel - Serum or Plasma

279

0.75

0.57

2.5

3.4

—

(3026008) Bacteria identified in Urine by Culture

268

0.74

0.56

2.9

3.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.53

0.55

1.1

1.5

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

669

0.81

0.54

5.0

5.3

1.75

2.75

ug/l

1.14

574

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

816

0.81

0.53

5.1

6.7

38.94

41.33

mmol/mol

1.93

751

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

837

0.83

0.44

4.3

5.0

5.82

6.19

mmol/l

3.15

739

(3012516) Albumin [Mass/volume] in Urine

290

0.79

0.43

3.1

3.2

58.21

299.64

mg/l

0.60

195

(3018677) aPTT in Platelet poor plasma by Coagulation assay

178

1.28

0.42

2.9

1.8

32.61

29.74

0.70

172

(3021440) Promyelocytes/100 leukocytes in Blood

1.40

0.41

3.6

4.3

0.00

0.09

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

330

0.81

0.41

2.8

2.3

82.23

74.24

nmol/l

0.50

285

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.40

0.0

3.5

—

4.08

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.40

0.0

3.5

—

106.22

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.40

0.0

3.5

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.40

0.0

1.2

—

268.67

—

(4034850) Laboratory test

1.45

0.40

17.8

15.1

—

(36304419) Bacteria [Presence] in Urine

274

1.22

0.39

2.9

3.0

—

(40768797) Stomach Pathology biopsy report

116

1.33

0.39

1.1

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.37

0.39

1.2

1.4

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.49

0.36

2.3

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

1.35

0.34

2.7

2.0

1.11

1.01

ug/l

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.32

0.33

2.3

3.8

4.30

4.36

pmol/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

415

1.17

0.32

2.0

2.1

99.36

89.81

pmol/l

0.40

233

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

213

1.22

0.32

4.2

2.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

435

0.85

0.32

3.9

5.4

0.10

0.00

estimate

—

105

(40761511) CBC panel - Blood by Automated count

894

0.86

0.31

23.0

16.9

—

(3017181) Myelocytes/100 leukocytes in Blood

1.32

0.31

3.6

4.2

0.80

0.92

—

(3015736) pH of Urine

331

0.84

0.31

3.2

4.1

—

5.98

—

(3009261) Glucose [Presence] in Urine by Test strip

443

0.86

0.30

3.5

4.0

0.00

estimate

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

813

0.87

0.29

21.0

17.1

73.95

73.10

ml/min/173m2

0.12

686

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

380

1.16

0.28

3.1

3.3

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.29

0.25

2.5

3.5

298.82

254.57

ng/l

0.12

(3000991) Gas panel - Venous blood

1.26

0.24

3.5

6.9

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

516

0.89

0.22

4.4

4.7

23.95

21.60

0.44

261

(3000494) Fungus identified in Specimen by Culture

1.25

0.22

1.2

1.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

373

0.88

0.21

3.6

3.2

0.66

0.78

ug/l

0.54

247

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.21

0.0

3.8

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

1.4

—

(3017569) Oxygen content in Arterial blood

0.00

0.21

0.0

1.8

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.3

—

(3004775) Volume in Urine collected for unspecified duration

0.00

0.21

0.0

1.8

—

491.29

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(40758558) Short blood count panel - Blood

223

1.15

0.20

5.6

5.7

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.18

0.19

2.2

2.7

3.35

2.84

g/l

—

(3044889) 12 lead EKG panel

642

0.91

0.18

4.7

4.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

101

1.21

0.17

2.0

1.8

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

542

1.09

0.15

3.4

3.1

75.88

54.36

u/l

0.83

504

(3026782) Osmolality of Urine

238

1.12

0.14

2.5

3.5

546.85

600.15

mosm/kgh2o

0.48

205

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

180

1.13

0.14

2.7

2.9

2.08

1.07

e6/l

0.27

113

(3021589) Normoblasts [#/volume] in Blood

416

1.09

0.13

14.7

10.7

0.00

0.01

e9/l

0.53

347

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

1.17

0.10

2.4

2.9

38.84

37.49

g/l

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

237

0.91

0.10

2.0

1.9

457.94

28788287.40

pmol/l

0.50

198

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.16

0.10

1.6

1.5

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

760

0.94

0.09

4.1

2.25

2.11

mu/l

0.50

654

(3022621) pH of Urine by Test strip

1.04

0.09

2.4

2.3

—

(3026493) Urate [Moles/volume] in Serum or Plasma

273

1.08

0.09

3.2

2.7

381.63

7489.36

umol/l

1.32

220

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.10

0.09

2.2

2.6

3.50

3.48

g/l

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.10

0.09

2.2

2.6

7.18

7.21

g/l

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.10

0.09

2.2

2.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

621

1.06

0.09

3.6

4.3

—

(36660697) Celiac disease serology panel - Serum

1.06

0.08

1.2

—

(3029937) Albumin [Presence] in Urine by Test strip

256

0.92

0.08

4.2

3.9

0.00

estimate

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.85

0.08

1.0

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.08

0.07

1.7

1.5

—

(3035350) Ketones [Presence] in Urine by Test strip

436

0.95

0.07

3.4

4.0

0.00

estimate

-0.00

112

(40761536) Microorganisms panel - Urine sediment

1.13

0.07

3.4

3.5

—

(3018095) Leukocytes [#/volume] in Urine

366

1.05

0.06

3.4

3.7

72.51

81.53

e6/l

0.06

290

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

180

0.94

0.04

3.3

3.1

2.30

0.87

e6/l

—

114

(3011397) Hemoglobin [Presence] in Urine by Test strip

180

1.07

0.04

3.7

—

(40768804) Tissue Pathology biopsy report

319

1.05

0.04

2.0

2.3

—

(3002256) Pathology report gross observation

111

1.09

0.04

1.5

1.4

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

371

0.96

0.04

2.5

2.7

268.00

166.59

ug/l

1.12

337

(3007164) IgA [Mass/volume] in Serum or Plasma

151

1.07

0.03

1.6

1.5

3.51

2.94

g/l

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

880

0.97

0.03

25.5

17.3

28.70

27.94

mg/l

0.08

730

(3021447) Carbon dioxide [Partial pressure] in Venous blood

108

0.92

0.03

2.5

4.1

6.73

5.70

kpa

—

103

(3007853) Bacteria identified in Skin by Aerobe culture

112

1.08

0.03

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

412

1.03

0.02

3.6

2.5

—

(3044640) Blood type and Crossmatch panel - Blood

293

1.03

0.01

4.0

2.3

—

(3013512) EKG study

319

1.00

0.00

4.2

4.6

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

187

1.02

0.00

5.5

3.7

2806.42

178.43

ng/l

0.46

160

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

425

0.98

0.00

2.6

2.5

—

(3003694) ABO and Rh group [Type] in Blood

215

0.97

0.00

1.4

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

591

1.00

0.00

3.5

3.3

14.96

14.77

pmol/l

0.21

504

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

-0.00

0.0

2.3

—

(40761535) Cells panel - Urine sediment

0.94

-0.00

5.9

3.5

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.2

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.02

-0.00

2.4

2.7

11.22

11.11

g/l

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

-0.00

0.0

1.1

—

8.96

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

16.87

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

-0.00

0.0

1.4

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3024354) Oxygen [Partial pressure] in Venous blood

1.01

-0.00

2.0

3.4

4.20

4.35

kpa

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.2

—

108.20

—

(40768793) Breast Pathology biopsy report

0.00

-0.00

0.0

1.6

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

96.17

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

-0.00

0.0

1.5

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

-0.00

0.0

2.0

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

16.86

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

173.29

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.8

—

87.20

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

-0.00

0.0

1.4

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

-0.00

0.0

2.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

1.77

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

2.9

—

217.57

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

1.9

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.6

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

12.24

—

(3006462) Nitrate [Presence] in Urine

0.00

-0.00

0.0

1.8

—

(3024263) Appearance of Synovial fluid

0.00

-0.00

0.0

1.3

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

3.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint J10_SILICAPNEUMOC and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
J10_SILICAPNEUMOC	1.875 [1.51, 2.33]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.019

During the follow-up period (1.1.1998 — 31.12.2019), 247 out of 466 males with J10_SILICAPNEUMOC died.

Mortality risk

Mortality risk for people of age

years, who have J10_SILICAPNEUMOC.

N-year risk	Females	Males
1	No data	0.447%
5	No data	2.501%
10	No data	5.67%
15	No data	10.948%
20	No data	18.021%

Relationships between endpoints

↥

Index endpoint: J10_SILICAPNEUMOC – Pneumoconiosis due to dust containing silica

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Pneumoconiosis due to dust containing silica

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints