Pneumoconiosis due to dust containing silica

J10_SILICAPNEUMOC

silicosis: Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20years) to low amounts of silica dust. Simple chronic silicosismay causepeople to have difficulty breathing. Accelerated silicosis occurs after 5 to 15 yearsof exposure of higher levels of silica.Swelling of the lungsand other symptoms occur faster in this type of silicosis than in the simple chronic form. Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica.The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months. People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J62 Hospital discharge: ICD-9 — 502 Hospital discharge: ICD-8 — 5150 Cause of death: ICD-10 — J62 Cause of death: ICD-9 — 502 Cause of death: ICD-8 — 5150 2 out of 7 registries used, show all original rules.	125
4. Check minimum number of events None	125
5. Include endpoints None	125
6. Filter based on genotype QC (FinnGen only)	125

Control definitions (FinnGen only)

Control exclude: J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: J60-J70
Name in latin: Silicosis

NAME	J10_SILICAPNEUMOC
CONTROL_EXCLUDE	J10_EXTERLUNG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J62
HD_ICD_9	502
HD_ICD_8	5150
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J62
COD_ICD_9	502
COD_ICD_8	5150
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Pneumoconiosis due to dust containing silica based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1139	103	997
Only index persons	595	70	525
Unadjusted period prevalence (%)
Whole population	0.03	0.00	0.03
Only index persons	0.02	0.00	0.02
Median age at first event (years)
Whole population	64.26	62.16	64.36
Only index persons	62.00	51.82	63.36

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	125	11	114
Unadjusted period prevalence (%)	0.05	0.00	0.05
Median age at first event (years)	64.12	41.77	66.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
108: Matched controls
1081

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

J62.8

ICD-10 Finland

Pneumoconiosis due to other dust containing silica

+∞

74.9

J62.0

ICD-10 Finland

Pneumoconiosis due to talc dust

+∞

48.7

R91

ICD-10 Finland

Abnormal findings on diagnostic imaging of lung

12.4

24.9

J92.0

ICD-10 Finland

Pleural plaque with presence of asbestos

34.0

17.3

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

15.9

14.2

UGC12

NOMESCO Finland

Flexible bronchoscopy

7.3

12.5

J61

ICD-10 Finland

Pneumoconiosis due to asbestos and other mineral fibres

+∞

11.7

51500

ICD-8 Finland

Pneumoconiosis due to silica and silicates, Silicosis

+∞

11.7

J62

ICD-10 Finland

Pneumoconiosis due to dust containing silica

+∞

11.7

5020A

ICD-9 Finland

Pneumoconiosis due to other silica or silicates[SILICOSIS]

+∞

10.6

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

19.8

9.7

J44.8

ICD-10 Finland

Other specified chronic obstructive pulmonary disease

4.2

8.4

110

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.2

7.6

366

H02AB06

ATC

prednisolone; systemic

3.0

7.0

343

Z57.2

ICD-10 Finland

Occupational exposure to dust

74.0

6.5

TGC00

NOMESCO Finland

Bronchial lavation

12.1

6.5

J69.0

ICD-10 Finland

Pneumonitis due to food and vomit

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

6.46

12.13

2.4

2.7

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

6.18

8.75

2.6

1.8

48.6

42.5

u/l

0.37

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

7.68

6.80

1.1

1.2

—

(3042631) Mycobacterium sp identified in Specimen

6.37

3.89

2.6

2.7

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

5.61

3.58

1.4

1.5

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

6.02

3.40

1.6

1.1

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

4.53

3.06

1.6

1.5

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

4.32

2.94

1.4

1.5

—

(3044927) Protein electrophoresis panel - Urine

6.93

2.90

1.0

1.1

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

6.93

2.90

1.2

1.9

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

6.93

2.90

1.2

1.9

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

6.93

2.90

1.2

1.9

—

(3019060) Gas panel - Arterial blood

2.46

2.76

4.8

2.9

—

(3023419) Bacteria identified in Sputum by Culture

6.24

2.73

4.7

2.4

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

5.67

2.57

1.2

1.6

—

(3023368) Bacteria identified in Blood by Culture

314

1.80

2.45

4.9

4.3

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

5.19

2.43

1.2

1.6

—

(42870588) Differential panel, method unspecified - Blood

319

1.76

2.30

9.3

5.3

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

4.79

2.30

2.0

1.5

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

4.79

2.30

1.8

2.9

5.1

4.4

e9/l

—

(1616796) Gas panel - Central venous blood

3.49

2.22

2.1

4.0

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

4.44

2.18

1.8

1.5

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

4.44

2.18

1.8

1.5

—

(3001604) Monocytes [#/volume] in Blood

435

1.67

2.10

6.3

5.6

0.7

0.6

e9/l

0.99

367

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

4.14

2.06

1.8

3.1

59.3

59.1

—

(3006315) Basophils [#/volume] in Blood

437

1.66

2.06

6.3

5.7

0.0

e9/l

0.46

372

(3037522) Nuclear Ab [Titer] in Serum

2.12

2.02

1.1

1.3

2128.0

417.8

titre

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

430

1.65

2.00

6.1

5.3

1.2

mmol/l

0.59

373

(3042936) Bacteria identified in Isolate by Culture

146

1.89

1.96

1.8

2.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.88

1.96

1.8

1.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

170

1.83

1.95

2.2

1.8

—

(3022313) Gas panel - Capillary blood

2.34

1.92

3.7

2.6

—

(3019198) Lymphocytes [#/volume] in Blood

447

1.61

1.82

6.4

5.7

1.7

1.9

e9/l

0.36

391

(3020891) Body temperature

2.56

1.80

5.2

4.5

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

2.09

1.79

3.8

2.7

5.1

5.0

kpa

0.36

(3023199) Leukocytes [#/volume] in Pleural fluid

3.67

1.63

1.2

1.4

4313.4

2742.7

e6/l

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.10

1.60

2.5

1.9

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

356

1.57

1.58

3.9

3.5

1520.9

1848.3

ng/l

0.37

310

(3018418) pH of Serum or Plasma

268

1.60

1.54

4.0

3.9

7.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.95

1.52

1.5

1.1

—

(3019225) pH of Specimen

1.89

1.48

5.2

3.4

—

(4010399)

2.00

1.46

1.5

1.4

—

(4035726)

2.00

1.46

1.6

1.5

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

1.36

0.0

7.1

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.85

1.32

1.2

1.3

1.1

15.9

u/ml

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

425

1.48

1.30

4.6

4.5

40.5

51.6

ng/l

0.43

333

(3022145) Colonoscopy Study observation

1.85

1.25

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.97

1.23

2.2

1.7

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.37

1.20

4.2

2.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

1.18

0.0

2.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.56

1.16

1.4

1.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.56

1.16

1.4

1.3

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.07

1.14

2.3

2.1

—

(3000492) Spirometry study

1.91

1.13

1.4

1.5

—

(3019309) Folate [Moles/volume] in Red Blood Cells

224

1.51

1.11

2.1

1.8

1040.9

1203.2

nmol/l

0.46

170

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

122

1.66

1.10

2.2

1.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.80

1.10

1.9

2.3

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.19

1.07

1.6

1.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

480

1.39

1.01

6.9

5.8

1.2

mmol/l

0.74

395

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.99

0.0

1.8

—

(3049717) Cytology report of Urine Cyto stain

1.79

0.94

2.0

2.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.82

0.93

1.7

1.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

506

1.36

0.90

11.3

8.6

4.7

4.3

e9/l

0.73

426

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

821

0.73

0.90

4.9

5.3

2.3

2.5

mmol/l

0.92

738

(3032080) INR in Blood by Coagulation assay

430

1.36

0.88

10.0

11.1

1.3

1.4

inr

0.16

128

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.98

0.85

1.8

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

175

1.46

0.83

4.5

5.6

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

1.86

0.80

1.8

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

338

0.71

0.79

4.0

4.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.78

0.0

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

117

1.52

0.76

4.5

3.6

—

(3025941) Bacteria identified in Stool by Culture

1.84

0.74

1.6

1.3

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.04

0.73

2.8

1.5

1.1

g/l

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.79

0.72

2.0

1.8

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

1.75

0.71

5.3

2.9

—

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.89

0.69

1.0

1.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

120

1.48

0.69

2.1

1.6

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

797

0.77

0.69

4.4

4.7

3.9

4.2

mmol/l

2.64

722

(3009542) Hematocrit [Volume Fraction] of Blood

705

0.79

0.63

25.3

18.5

40.0

39.1

0.25

437

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.64

0.63

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

773

0.79

0.62

4.1

4.2

1.2

1.3

mmol/l

0.54

685

(3041096) Erythrocytes [Presence] in Urine by Automated

250

0.72

0.62

3.0

4.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.58

0.61

1.1

1.6

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

781

0.79

0.60

5.3

6.9

39.2

41.5

mmol/mol

1.73

718

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

790

0.79

0.59

4.4

4.7

1.2

1.3

mmol/l

2.80

703

(3020682) Albumin/Creatinine [Ratio] in Urine

298

0.76

0.54

3.8

4.0

4.3

12.8

mg/mmol

1.77

197

(40768797) Stomach Pathology biopsy report

109

1.43

0.54

1.1

1.2

—

(1761868) Lipid panel - Serum or Plasma

265

0.75

0.53

2.5

3.3

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.52

0.52

2.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.41

0.52

1.2

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

103

1.40

0.47

7.8

9.3

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

639

0.83

0.44

5.0

5.3

1.7

2.8

ug/l

1.16

547

(36304419) Bacteria [Presence] in Urine

261

1.25

0.44

3.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

205

1.27

0.44

4.2

2.2

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

311

0.79

0.44

2.9

2.3

78.3

74.7

nmol/l

0.18

268

(3028626) Oxygen [Partial pressure] in Capillary blood

1.64

0.43

4.2

2.6

7.9

8.4

kpa

—

(4034850)

1.54

0.42

17.8

15.9

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.40

0.0

3.5

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.40

0.0

3.5

—

4.1

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.40

0.0

3.5

—

106.2

—

(3026008) Bacteria identified in Urine by Culture

255

0.79

0.40

2.9

3.1

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.39

0.0

1.2

—

263.6

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

171

1.27

0.39

3.0

1.8

33.1

29.7

0.84

165

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.41

0.35

2.3

3.9

4.3

4.4

pmol/l

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

1.41

0.35

2.7

2.0

1.1

ug/l

—

(3000850) Epithelial cells [#/volume] in Urine

230

1.22

0.35

2.2

2.5

5.1

3.3

e6/l

0.37

199

(3021601) Nitrite [Presence] in Urine by Test strip

417

0.84

0.35

4.0

5.5

0.1

0.0

estimate

—

(3026782) Osmolality of Urine

221

1.22

0.34

2.5

3.4

546.8

613.3

mosm/kgh2o

0.64

191

(40761511) CBC panel - Blood by Automated count

856

0.85

0.34

23.8

17.0

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

777

0.85

0.33

21.8

17.1

73.4

72.7

ml/min/173m2

0.10

650

(3000991) Gas panel - Venous blood

1.34

0.33

3.5

7.1

—

(3009261) Glucose [Presence] in Urine by Test strip

423

0.85

0.30

3.7

4.1

0.0

estimate

—

(3037467) Urinalysis macro (dipstick) panel - Urine

595

1.15

0.30

3.6

4.3

—

(3012516) Albumin [Mass/volume] in Urine

278

0.83

0.30

3.1

3.2

58.2

311.7

mg/l

0.60

187

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.32

0.29

2.5

3.5

298.8

256.8

ng/l

0.11

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

802

0.87

0.29

4.3

5.1

5.8

6.2

mmol/l

3.03

710

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

400

1.15

0.28

2.0

2.1

99.3

89.8

pmol/l

0.38

224

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.29

0.27

2.0

1.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

363

1.15

0.26

3.3

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

1.26

0.22

2.4

3.0

38.8

37.3

g/l

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.5

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.21

0.0

1.4

—

(3017569) Oxygen content in Arterial blood

0.00

0.21

0.0

1.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3004775) Volume in Urine collected for unspecified duration

0.00

0.21

0.0

1.8

—

491.3

—

(3029937) Albumin [Presence] in Urine by Test strip

247

0.87

0.19

4.5

3.9

0.0

estimate

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.16

0.19

2.2

2.7

—

(3000494) Fungus identified in Specimen by Culture

1.23

0.18

1.3

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

490

0.90

0.17

4.4

4.7

24.5

21.7

0.51

250

(40758558) Short blood count panel - Blood

216

1.14

0.17

5.8

5.7

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

0.77

0.16

1.3

1.9

1.6

1.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.13

0.15

1.7

1.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

170

1.14

0.14

2.8

2.3

1.1

e6/l

0.27

108

(3002256) Pathology report gross observation

104

1.17

0.13

1.5

1.4

—

(40761536) Microorganisms panel - Urine sediment

1.19

0.13

3.4

3.6

—

(3044889) 12 lead EKG panel

614

0.93

0.12

4.8

4.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

351

0.92

0.11

3.7

3.2

0.7

0.8

ug/l

0.60

231

(3018095) Leukocytes [#/volume] in Urine

350

1.08

0.11

3.5

3.7

74.9

83.6

e6/l

0.06

280

(40768804) Tissue Pathology biopsy report

301

1.08

0.10

2.0

2.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

106

1.15

0.10

1.8

—

(3022621) pH of Urine by Test strip

1.12

0.10

2.4

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.09

0.09

2.4

2.8

11.2

10.9

g/l

—

(3044640) Blood type and Crossmatch panel - Blood

283

1.08

0.09

4.0

2.3

—

(36660697) Celiac disease serology panel - Serum

1.12

0.09

1.2

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

357

0.93

0.08

2.6

2.8

269.3

169.1

ug/l

1.00

327

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.04

0.07

1.8

1.6

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

406

0.94

0.07

2.7

2.5

—

(3035350) Ketones [Presence] in Urine by Test strip

416

0.94

0.07

3.5

4.1

0.0

estimate

0.00

(3026493) Urate [Moles/volume] in Serum or Plasma

266

1.07

0.07

3.2

2.8

381.9

7688.3

umol/l

1.32

214

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

395

1.06

0.06

5.2

4.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

845

0.95

0.06

26.4

17.3

29.6

28.3

mg/l

0.13

702

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

232

0.94

0.05

2.0

1.9

457.9

29381855.7

pmol/l

0.50

194

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

518

1.04

0.04

3.5

3.1

67.3

54.5

u/l

0.65

482

(3021589) Normoblasts [#/volume] in Blood

399

1.04

0.04

15.5

10.7

0.0

e9/l

0.53

331

(3007164) IgA [Mass/volume] in Serum or Plasma

144

1.05

0.00

1.5

3.0

2.8

g/l

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

184

1.04

0.00

5.5

3.7

2806.4

181.0

ng/l

0.46

157

(3003694) ABO and Rh group [Type] in Blood

204

1.04

0.00

1.4

1.3

—

(3013512) EKG study

306

0.97

0.00

4.2

4.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

726

0.98

0.00

4.1

2.3

2.1

mu/l

0.61

626

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

171

0.99

0.00

3.3

3.0

2.3

0.9

e6/l

—

110

(3011397) Hemoglobin [Presence] in Urine by Test strip

173

0.98

0.00

4.0

3.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

569

1.00

0.00

3.5

3.3

14.9

14.7

pmol/l

0.21

484

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.3

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

0.0

1.2

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(44806420)

0.00

0.0

2.7

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

0.0

1.0

—

16.9

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.5

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.7

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

2.0

—

(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood

0.00

0.0

1.8

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.4

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

2.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.4

—

(4024509)

0.00

0.0

1.3

—

(40761535) Cells panel - Urine sediment

0.97

0.00

5.9

3.6

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.9

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.6

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

1.7

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

3.8

—

87.2

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.2

—

108.2

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.4

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

2.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.88

0.00

1.0

1.6

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

3.8

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.0

1.1

—

12.2

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

16.9

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

2.9

—

217.6

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

2.6

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint J10_SILICAPNEUMOC and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
J10_SILICAPNEUMOC	1.875 [1.51, 2.33]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.019

During the follow-up period (1.1.1998 — 31.12.2019), 247 out of 466 males with J10_SILICAPNEUMOC died.

Mortality risk

Mortality risk for people of age

years, who have J10_SILICAPNEUMOC.

N-year risk	Females	Males
1	No data	0.447%
5	No data	2.501%
10	No data	5.67%
15	No data	10.948%
20	No data	18.021%

Relationships between endpoints

↥

Index endpoint: J10_SILICAPNEUMOC – Pneumoconiosis due to dust containing silica

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Pneumoconiosis due to dust containing silica

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints