Myositis ossificans

M13_MYOSITISOSSIF

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M61.0, M61.1 Hospital discharge: ICD-9 — 7281A Cause of death: ICD-10 — M61.0, M61.1 Cause of death: ICD-9 — 7281A 2 out of 7 registries used, show all original rules.	107
4. Check minimum number of events None	107
5. Include endpoints None	107
6. Filter based on genotype QC (FinnGen only)	107

Control definitions (FinnGen only)

Control exclude: M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	M13_MYOSITISOSSIF
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M61[0-1]
HD_ICD_9	7281A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M61[0-1]
COD_ICD_9	7281A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Myositis ossificans based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	910	446	457
Only index persons	779	393	386
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	56.97	59.89	54.01
Only index persons	54.29	56.07	52.48

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	107	48	59
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	51.11	48.80	52.99

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
96: Matched controls
960

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M61.1

ICD-10 Finland

Myositis ossificans progressiva

+∞

51.8

M61.0

ICD-10 Finland

Myositis ossificans traumatica

+∞

46.7

M16.1

ICD-10 Finland

Other primary coxarthrosis

13.5

22.3

M16.0

ICD-10 Finland

Primary coxarthrosis, bilateral

12.0

M79.6

ICD-10 Finland

Pain in limb

5.2

11.8

139

7281A

ICD-9 Finland

Disorders of muscle, ligament and fascia, Muscular calcification and ossification[MYOSITIS PROGRESSIVA OSSIFICANS]

+∞

10.6

WX002

NOMESCO Finland

Sedation and analgesia

5.1

9.9

NF1AA

NOMESCO Finland

Hip X-ray examination

8.4

9.5

ZXA00

NOMESCO Finland

Right side

4.5

9.3

121

T84.0

ICD-10 Finland

Mechanical complication of internal joint prosthesis

21.2

9.2

B01AB05

ATC

enoxaparin; parenteral

4.2

9.0

144

N03AX16

ATC

pregabalin; oral

4.6

9.0

106

NFB50

NOMESCO Finland

Primary total prosthetic replacement of hip joint using cement

16.9

7.9

N02BE01

ATC

paracetamol; systemic, rectal

5.2

7.4

625

M48.0

ICD-10 Finland

Spinal stenosis

5.3

7.4

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

5.5

7.2

N02AX02

ATC

tramadol; systemic, rectal

3.3

7.1

247

NF1BA

NOMESCO Finland

Hip extensive X-ray examination

13.6

6.8

M01AC06

ATC

meloxicam; systemic, rectal

3.3

6.7

189

L13

ICPC

Hip symptom/complaint

4.6

6.5

M01AX05

ATC

glucosamine; oral

4.1

6.3

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

3.0

6.3

238

M01AE03

ATC

ketoprofen; systemic, rectal

3.0

6.2

230

M75.1

ICD-10 Finland

Rotator cuff syndrome

4.3

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3042936) Bacteria identified in Isolate by Culture

3.65

7.40

2.3

2.6

—

(3006315) Basophils [#/volume] in Blood

377

2.74

6.03

5.0

5.7

0.0

e9/l

0.67

326

(3019198) Lymphocytes [#/volume] in Blood

386

2.64

5.61

5.0

5.9

1.7

1.9

e9/l

0.41

342

(3001604) Monocytes [#/volume] in Blood

377

2.53

5.22

5.1

5.6

0.6

e9/l

0.33

326

(3032080) INR in Blood by Coagulation assay

326

2.51

5.16

11.6

8.2

1.2

1.3

inr

0.22

113

(3026008) Bacteria identified in Urine by Culture

214

2.58

5.13

5.7

3.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

358

2.44

4.90

8.0

8.6

1.2

mmol/l

0.30

292

(3013115) Eosinophils [#/volume] in Blood

387

2.43

4.80

5.2

6.3

0.2

e9/l

1.03

340

(3044889) 12 lead EKG panel

548

2.56

4.54

4.4

3.7

—

(3023368) Bacteria identified in Blood by Culture

202

2.46

4.51

5.8

4.4

—

(40758558) Short blood count panel - Blood

196

2.46

4.43

4.4

6.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

353

2.32

4.37

5.2

4.1

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

448

2.33

4.24

6.6

10.0

4.0

4.2

e9/l

0.31

386

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

272

2.30

4.18

2.5

1.8

88.5

94.2

pmol/l

0.39

129

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.88

3.90

2.3

1.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.88

3.90

2.3

1.8

—

(3012516) Albumin [Mass/volume] in Urine

196

2.26

3.62

3.6

3.2

3239.1

72.0

mg/l

0.77

127

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.53

3.46

2.7

1.7

—

(42870588) Differential panel, method unspecified - Blood

265

2.12

3.42

4.7

5.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

119

2.44

3.38

2.3

1.8

—

(3045414) Leukocytes [Presence] in Urine

4.81

3.19

1.7

1.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

714

2.47

3.13

5.5

4.1

1.9

mu/l

0.03

629

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

161

2.20

3.07

1.9

1.7

0.8

1.5

mg/l

2.00

132

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

575

2.11

3.06

4.4

3.5

14.5

14.8

pmol/l

0.68

509

(3019309) Folate [Moles/volume] in Red Blood Cells

126

2.28

2.96

1.6

1.7

1157.0

1295.2

nmol/l

0.25

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

5.68

2.92

1.4

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

5.68

2.92

1.4

1.0

—

(3044640) Blood type and Crossmatch panel - Blood

254

2.00

2.86

2.8

2.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

748

2.45

2.84

24.4

14.9

38.6

40.1

0.72

545

(40761511) CBC panel - Blood by Automated count

861

3.00

2.82

19.2

12.2

—

(3002582) Erythrocytes [#/volume] in Urine

248

1.98

2.77

5.2

2.8

85.5

327.7

e6/l

0.41

179

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

191

2.05

2.76

2.4

2.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.39

2.76

3.8

6.9

1.1

1.0

mmol/l

0.20

(3037467) Urinalysis macro (dipstick) panel - Urine

537

1.96

2.70

6.2

3.8

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

131

2.19

2.69

3.8

2.6

2.2

2.4

e6/l

0.07

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

140

2.13

2.61

3.2

2.4

0.5

1.3

e6/l

1.50

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

5.70

2.58

2.7

1.6

—

(3044941) Cell count panel - Synovial fluid

7.42

2.57

1.6

1.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

215

1.93

2.45

3.8

3.9

1.2

11.6

mg/mmol

2.12

133

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

225

1.90

2.39

2.6

3.1

1190.2

1421.3

ng/l

0.26

185

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

153

2.02

2.37

2.7

3.3

2.4

mmol/l

0.01

138

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

803

2.40

2.35

24.5

13.6

26.1

25.5

mg/l

0.06

619

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

289

1.82

2.26

5.2

2.7

—

(3014051) Protein [Presence] in Urine by Test strip

5.76

2.24

1.6

2.1

—

(3018095) Leukocytes [#/volume] in Urine

281

1.81

2.23

6.4

3.3

61.8

110.9

e6/l

0.63

191

(36304419) Bacteria [Presence] in Urine

214

1.86

2.19

5.0

2.6

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.47

2.18

1.7

1.1

—

(3009508) Creatinine [Moles/volume] in Urine

215

1.85

2.16

3.5

2.9

7.7

8.0

mmol/l

0.13

174

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

801

2.23

2.11

4.2

4.1

4.5

4.7

mmol/l

0.76

737

(3014765) Yersinia sp identified in Stool by Organism specific culture

3.67

2.09

1.4

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

3.67

2.09

1.4

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

395

1.74

2.09

4.7

3.6

0.0

estimate

—

(3021589) Normoblasts [#/volume] in Blood

359

1.74

2.06

10.3

10.5

0.0

e9/l

0.57

301

(3027945) Reticulocytes/100 erythrocytes in Blood

2.24

2.03

1.9

2.6

1.6

1.8

0.38

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

306

1.74

2.02

4.1

3.7

26.3

32.6

ng/l

0.31

209

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

3.49

2.00

1.4

1.2

—

(36660697) Celiac disease serology panel - Serum

2.41

2.00

1.1

—

(3000494) Fungus identified in Specimen by Culture

2.16

1.98

1.3

1.6

—

(3000991) Gas panel - Venous blood

2.33

1.98

10.1

12.3

—

(3035350) Ketones [Presence] in Urine by Test strip

390

1.71

1.98

4.7

3.6

0.0

estimate

—

(3021788) Differential panel - Synovial fluid

4.71

1.96

3.2

1.2

—

(3018418) pH of Serum or Plasma

230

1.78

1.94

4.6

4.3

7.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

797

2.10

1.93

3.9

4.1

1.4

1.5

mmol/l

0.29

723

(3021601) Nitrite [Presence] in Urine by Test strip

393

1.69

1.90

6.1

5.0

0.0

estimate

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.15

1.86

1.5

3.9

268.7

238.8

u/l

0.39

(3030467) Casts [#/volume] in Urine by Automated count

225

1.75

1.83

5.3

2.6

0.2

0.5

e6/l

1.31

158

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.47

1.77

2.8

1.4

—

(3007164) IgA [Mass/volume] in Serum or Plasma

152

1.84

1.77

1.4

2.8

2.6

g/l

0.14

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

820

2.03

1.68

4.9

4.6

2.6

2.8

mmol/l

0.74

743

(3015377) Calcium [Moles/volume] in Serum or Plasma

274

1.67

2.6

3.4

2.4

2.3

mmol/l

0.11

244

(3012544) pH of Venous blood

2.12

1.62

4.5

5.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

778

1.86

1.59

3.5

3.8

1.3

mmol/l

0.10

708

(3007853) Bacteria identified in Skin by Aerobe culture

2.05

1.59

1.8

1.6

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.24

1.50

7.1

8.0

25.7

24.8

mmol/l

0.54

(3022621) pH of Urine by Test strip

2.49

1.50

2.2

3.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.70

1.39

1.7

3.1

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.25

1.37

11.4

25.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

177

1.62

1.23

3.6

3.5

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

2.71

1.23

1.6

1.4

43.8

41.2

nmol/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.04

1.22

1.2

1.8

—

(3049717) Cytology report of Urine Cyto stain

2.38

1.20

2.8

2.3

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.38

1.20

1.2

1.0

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

332

1.49

1.17

2.9

2.4

160.2

133.5

ug/l

0.17

299

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.57

1.16

1.0

1.3

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

105

1.74

1.14

1.1

1.2

2.1

8.3

u/ml

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

251

1.52

1.14

3.9

4.0

22.8

22.1

0.07

125

(3022313) Gas panel - Capillary blood

2.34

1.12

4.6

2.8

—

(3019225) pH of Specimen

1.96

1.12

4.5

3.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

796

1.59

1.03

4.9

4.2

6.0

5.9

mmol/l

0.38

716

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.07

1.02

1.4

1.5

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

177

1.54

1.00

3.5

2.9

0.9

0.8

ug/l

0.25

122

(3014007) Fractional oxyhemoglobin in Arterial blood

1.94

1.00

12.1

12.6

94.6

93.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

169

1.54

0.99

4.0

4.6

—

(3000492) Spirometry study

1.86

0.98

1.5

1.8

—

(4034850)

2.29

0.95

11.7

6.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.29

0.95

2.3

2.2

—

(3013512) EKG study

233

1.47

0.94

5.0

4.0

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.93

0.89

4.6

3.3

1.9

1.7

mmol/l

—

(3022145) Colonoscopy Study observation

1.66

0.86

1.4

1.3

—

(3009343) pH of Capillary blood

1.80

0.84

4.6

3.2

—

7.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

480

1.35

0.77

3.6

2.9

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

161

1.46

0.76

1.2

1.6

356.0

433.3

pmol/l

1.27

140

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.13

0.75

1.2

1.5

—

(40768804) Tissue Pathology biopsy report

299

1.36

0.74

2.5

2.1

—

(3000330) Specific gravity of Urine by Test strip

1.80

0.73

2.4

5.2

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

1.97

0.71

1.2

2.6

110.8

333.4

ug/l

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.89

0.69

2.0

1.6

—

(1761868) Lipid panel - Serum or Plasma

324

0.74

0.62

2.5

2.8

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.70

0.62

2.2

1.7

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.59

0.0

1.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

225

1.33

0.57

5.0

3.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.49

0.55

2.2

2.7

—

(40761535) Cells panel - Urine sediment

1.49

0.55

3.4

3.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.50

0.54

6.1

3.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

742

1.31

0.54

6.3

5.4

40.9

39.5

mmol/mol

0.62

691

(3020779) Urea [Moles/volume] in Serum or Plasma

1.54

0.52

5.5

9.2

9.8

9.7

mmol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

314

1.27

0.51

5.1

3.8

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.56

0.49

1.1

1.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.44

0.48

7.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.60

0.48

1.0

1.3

—

(3019060) Gas panel - Arterial blood

1.49

0.44

4.1

12.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.64

0.43

3.2

1.8

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.41

0.0

1.1

—

0.9

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.2

—

(40768793) Breast Pathology biopsy report

0.00

0.41

0.0

1.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.49

0.41

7.2

3.7

57.6

50.7

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.40

0.0

1.3

—

(3003694) ABO and Rh group [Type] in Blood

208

1.26

0.40

1.4

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.39

0.0

2.6

—

16.5

—

(3029937) Albumin [Presence] in Urine by Test strip

210

1.25

0.37

6.2

3.9

0.0

estimate

—

(40761536) Microorganisms panel - Urine sediment

0.64

0.37

17.6

3.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.45

0.36

1.7

1.6

—

(3002256) Pathology report gross observation

110

1.31

0.34

1.7

1.3

—

(3025941) Bacteria identified in Stool by Culture

1.32

0.33

1.3

—

(40768797) Stomach Pathology biopsy report

104

1.28

0.28

1.1

1.3

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

776

1.18

0.26

22.9

12.6

83.5

80.9

ml/min/173m2

0.41

621

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.30

0.23

1.2

1.1

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.21

0.0

1.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.9

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.20

0.0

1.3

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.20

0.0

4.6

—

74.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.20

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.20

0.0

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.20

0.0

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.16

0.19

3.2

2.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.73

0.17

1.6

1.8

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.15

0.17

3.6

4.2

1.2

mmol/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

116

0.85

0.12

1.6

1.5

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.12

0.09

1.7

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.08

0.07

2.0

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

131

1.08

0.04

2.2

1.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

102

1.09

0.03

1.5

1.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.03

0.00

1.6

1.5

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

2.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.01

0.00

1.5

1.6

—

(3011648) Oxygen content in Venous blood

0.00

0.0

6.0

—

11.6

—

(4281824)

0.00

0.0

1.0

—

(4010399)

0.86

0.00

1.2

1.4

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

3.0

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3000012) Reticulocyte production index

0.00

0.0

2.2

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

12.2

—

675.2

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.5

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(4035726)

0.89

0.00

1.4

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

1.2

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

6.9

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

2.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

2.2

—

(4268621)

0.00

0.0

1.9

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

2.2

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.0

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

2.2

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.02

0.00

1.1

1.5

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.4

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

15.0

—

1193.8

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.2

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.9

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

2.0

—

953.2

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.02

0.00

2.7

2.6

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

130

1.00

0.00

1.4

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_MYOSITISOSSIF and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_MYOSITISOSSIF	1.458 [1.13, 1.89]	0.004
Birth year	0.992 [0.98, 1.0]	0.071

During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 381 females with M13_MYOSITISOSSIF died.

Males

Parameter	HR [95% CI]	p-value
M13_MYOSITISOSSIF	1.557 [1.22, 1.98]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.048

During the follow-up period (1.1.1998 — 31.12.2019), 111 out of 355 males with M13_MYOSITISOSSIF died.

Mortality risk

Mortality risk for people of age

years, who have M13_MYOSITISOSSIF.

N-year risk	Females	Males
1	0.146%	0.386%
5	0.821%	2.098%
10	1.829%	5.174%
15	3.638%	9.824%
20	6.346%	16.21%

Relationships between endpoints

↥

Index endpoint: M13_MYOSITISOSSIF – Myositis ossificans

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Myositis ossificans

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints