Maternal care for (suspected) damage to fetus from alcohol

MATERNCAREFETUSALCO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O35.4
  • Cause of death: ICD-10 O35.4

2 out of 7 registries used, show all original rules.

123

4. Check minimum number of events

None

123

5. Include endpoints

None

123

6. Filter based on genotype QC (FinnGen only)

123

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
O35
Name in latin
Cura matris propter laesionem [suspectam] fetus ex abusu alcohol matris

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 998 989 -
Only index persons 962 962 -
Unadjusted period prevalence (%)
Whole population 0.03 0.03 -
Only index persons 0.04 0.04 -
Median age at first event (years)
Whole population - 29.01 -
Only index persons - 28.94 -

-FinnGen-

Key figures

All Female Male
Number of individuals 123 123 -
Unadjusted period prevalence (%) 0.04 0.04 -
Median age at first event (years) 30.11 30.11 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
114
Matched controls
1141
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O35.4
ICD-10 Finland
Maternal care for (suspected) damage to fetus from alcohol
+∞
164.5
114
*
O35.5
ICD-10 Finland
Maternal care for (suspected) damage to fetus by drugs
+∞
42.4
38
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
29.2
31.5
43
23
N07BB01
ATC
disulfiram; oral
19.7
21.6
33
23
B18.2
ICD-10 Finland
Chronic viral hepatitis C
45.1
20.9
25
7
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
7.4
20.1
59
144
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
67.4
19.7
22
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
11.6
19.3
38
47
RS120
NOMESCO Finland
NA
+∞
19.3
18
*
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
6.5
19.2
82
321
F32.9
ICD-10 Finland
Depressive episode, unspecified
7.0
17.1
49
110
F10.20
ICD-10 Finland
Alcohol dependence currently independent
47.9
17.0
20
5
N05BA04
ATC
oxazepam; oral
5.8
16.6
61
188
T36
ICD-10 Finland
Poisoning by systemic antibiotics
12.7
16.5
30
31
Z64.0
ICD-10 Finland
Problems related to unwanted pregnancy
11.0
16.2
32
39
N05AH04
ATC
quetiapine; oral
5.9
15.5
52
141
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
5.4
15.3
59
188
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
5.5
15.0
55
164
Z35.7
ICD-10 Finland
Supervision of high-risk pregnancy due to social problems
92.3
15.0
16
*
P15
ICPC
Chronic alcohol abuse
26.6
14.8
20
9
N06AX11
ATC
mirtazapine; oral
4.9
14.2
65
242
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
14.1
13.6
23
20
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
15.8
13.1
21
16
F10.25
ICD-10 Finland
Alcohol dependence continuous use
145.3
12.7
13
*
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
10.9
12.5
24
27
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
15.9
12.5
20
15
Z37.0
ICD-10 Finland
Single live birth
4.6
12.1
53
182
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
11.6
11.9
22
23
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
132.9
11.7
12
*
N05BA01
ATC
diazepam; systemic, rectal
7.5
11.6
28
47
T74.1
ICD-10 Finland
Physical abuse
23.0
11.5
16
8
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
16.2
11.4
18
13
N06AB04
ATC
citalopram; systemic
4.7
11.4
46
144
N05BA12
ATC
alprazolam; oral
7.4
11.4
28
48
WX892
NOMESCO Finland
Monitored bed care
14.0
11.3
19
16
XF400
NOMESCO Finland
ECG with 12 standard connections
7.5
11.2
27
45
Z72.2
ICD-10 Finland
Drug use
48.5
11.2
13
*
F10.24
ICD-10 Finland
Alcohol depence active use
31.5
11.0
14
5
X14
ICPC
Vaginal discharge
11.3
10.8
20
21
Z32.1
ICD-10 Finland
Pregnancy confirmed
4.2
10.7
52
191
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
120.6
10.6
11
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
15.1
10.6
17
13
LCH11
NOMESCO Finland
Pharmacologic abortion
5.5
10.4
33
79
Z71.8
ICD-10 Finland
Other specified counselling
4.0
10.3
54
210
MAX99
NOMESCO Finland
Assistance to normal delivery
4.0
10.2
51
191
P19
ICPC
Drug abuse
44.2
10.2
12
*
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
3.7
10.1
67
316
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
10.6
10.0
19
21
F11.25
ICD-10 Finland
Relationship caused by opiates continuously used
60.3
9.8
11
*
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
4.1
9.7
45
157
RS310
NOMESCO Finland
NA
+∞
9.5
9
*
O98.4
ICD-10 Finland
Viral hepatitis complicating pregnancy, childbirth and the puerperium
+∞
9.5
9
*
RS122
NOMESCO Finland
NA
+∞
9.5
9
*
P29
ICPC
Psychological sympt/compl other
6.8
9.4
24
43
D01
ICPC
Abdominal pain/cramps general
5.1
9.4
31
77
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
10.0
9.2
18
21
N05AH03
ATC
olanzapine; systemic
7.3
9.2
22
36
P01AB01
ATC
metronidazole; oral, rectal
3.4
8.9
68
348
N05AX08
ATC
risperidone; systemic
7.3
8.8
21
34
F11.22
ICD-10 Finland
Addiction-induced dependence is currently independent but uses substitute intermittent medication
54.3
8.8
10
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.5
8.7
33
94
IGY99
NOMESCO Finland
Other psychiatric treatment contact
14.3
8.6
14
11
N05BA02
ATC
chlordiazepoxide; systemic
96.9
8.5
9
*
N06AB10
ATC
escitalopram; oral
3.4
8.5
53
232
F13.25
ICD-10 Finland
Addiction caused by sedative and hypnotic continuous use
+∞
8.4
8
*
F15.1
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, harmful use
+∞
8.4
8
*
V03AA01
ATC
NA
+∞
8.4
8
*
F61.0
ICD-10 Finland
Mixed personality disorders
18.9
8.3
12
7
N05CF01
ATC
zopiclone; oral
3.7
8.3
42
154
XMA22
NOMESCO Finland
General examination of pregnant woman
4.3
8.2
33
99
TQX20
NOMESCO Finland
Implantation of subcutaneous medicament implant
24.1
8.2
11
5
N03AG01
ATC
valproic acid; systemic, rectal
6.9
8.1
20
34
W01
ICPC
Question of pregnancy
14.5
8.1
13
10
P74
ICPC
Anxiety disorder/anxiety state
7.7
8.0
18
27
N06AX16
ATC
venlafaxine; oral
3.8
7.9
37
128
N05CD07
ATC
temazepam; oral
10.0
7.8
15
17
R2110
NOMESCO Finland
Giving the first information
5.0
7.7
25
60
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
4.1
7.6
32
100
X23
ICPC
Fear sexually transm dis female
4.3
7.6
29
83
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
4.0
7.5
32
101
Z86.4
ICD-10 Finland
Personal history of psychoactive substance abuse
85.4
7.5
8
*
T51.0
ICD-10 Finland
Toxic effect: Ethanol
85.4
7.5
8
*
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
85.4
7.5
8
*
F15.2
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome
85.4
7.5
8
*
R05
ICPC
Cough
3.4
7.4
43
174
W14
ICPC
Contraception female other
4.5
7.4
27
74
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
+∞
7.4
7
*
B17.1
ICD-10 Finland
Acute hepatitis C
+∞
7.4
7
*
D10
ICPC
Vomiting
4.7
7.3
25
64
P76
ICPC
Depressive disorder
4.9
7.3
24
59
D25
ICPC
Abdominal distension
21.7
7.3
10
5
N06AA12
ATC
doxepin; systemic
21.7
7.3
10
5
F39
ICD-10 Finland
Unspecified mood [affective] disorder
13.2
7.3
12
10
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
32.3
7.3
9
*
U01
ICPC
Dysuria/painful urination
5.5
7.2
21
45
SPAT1324
SPAT
Screening procedure
0.1
7.1
*
255
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
10.3
7.0
13
14
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
12.0
7.0
12
11
D12
ICPC
Constipation
18.1
6.9
10
6
Z04.4
ICD-10 Finland
Examination and observation following alleged rape and seduction
18.1
6.9
10
6
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
18.1
6.9
10
6
RS121
NOMESCO Finland
NA
42.7
6.8
8
*
F13.22
ICD-10 Finland
Addiction relationship caused by sedatives and hypnotics currently independent but uses substitute intermittent medication
42.7
6.8
8
*
L12
ICPC
Hand/finger symptom/complaint
3.9
6.8
29
91
F31.8
ICD-10 Finland
Other bipolar affective disorders
9.6
6.8
13
15
L02
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle
13.4
6.7
11
9
EBA30
NOMESCO Finland
Excision of root of tooth
13.4
6.7
11
9
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
13.4
6.7
11
9
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.5
6.7
24
64
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
5.9
6.7
18
35
WX110
NOMESCO Finland
Local anesthesy
3.6
6.6
98
718
P01
ICPC
Feeling anxious/nervous/tense
3.3
6.5
36
139
B86
ICD-10 Finland
Scabies
15.5
6.5
10
7
K08.3
ICD-10 Finland
Retained dental root
10.2
6.5
12
13
N05AF03
ATC
chlorprothixene; systemic
12.0
6.4
11
10
N06AB06
ATC
sertraline; oral
3.9
6.4
27
84
A46
ICD-10 Finland
Erysipelas
7.0
6.4
15
24
R74
ICPC
Upper respiratory infection acute
2.8
6.4
64
361
Z72.1
ICD-10 Finland
Alcohol use
19.3
6.4
9
5
SPAT1265
SPAT
Breathalyser
19.3
6.4
9
5
P03
ICPC
Feeling depressed
3.6
6.4
30
103
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
8.5
6.3
13
17
TUPKY
NOMESCO Finland
NA
28.4
6.3
8
*
S72
ICPC
Scabies/other acariasis
+∞
6.3
6
*
F60.2
ICD-10 Finland
Dissocial personality disorder
+∞
6.3
6
*
RS312
NOMESCO Finland
NA
+∞
6.3
6
*
F11.20
ICD-10 Finland
Addiction-induced dependence caused by opiates currently independent
+∞
6.3
6
*
EB1AA
SPAT
NA
6.2
6.3
16
29
F41.00
ICD-10 Finland
Moderate panic disorder
9.4
6.2
12
14
D06
ICPC
Abdominal pain localized other
4.2
6.2
23
64
IGY02
NOMESCO Finland
Psychiatric monitoring contact
8.0
6.1
13
18
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
16.1
6.0
9
6
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
16.1
6.0
9
6
P27
ICPC
Fear of mental disorder
16.1
6.0
9
6
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.4
6.0
21
55

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
37
53
9.55
26.21
3.1
1.5
—
—
—
0
0
42
71
8.46
25.87
5.7
2.0
—
—
—
0
0
41
91
6.26
18.98
4.0
1.5
—
—
—
0
0
42
98
5.99
18.38
3.9
1.5
—
—
—
0
0
42
98
5.99
18.38
3.9
1.5
—
—
—
0
0
42
99
5.92
18.16
3.8
1.5
—
—
—
0
0
41
98
5.78
17.40
4.0
1.5
—
—
—
0
0
36
83
5.72
15.77
3.0
1.5
—
—
—
0
0
21
29
8.53
14.90
1.8
1.2
—
—
—
0
0
41
117
4.76
13.85
1.7
1.4
—
—
—
0
0
14
13
12.02
13.09
1.7
1.2
—
—
—
0
0
86
448
4.06
12.06
5.8
4.9
11.9
9.1
umol/l
0.85
81
421
55
218
3.75
11.57
3.0
2.3
0.2
0.4
e6/l
0.49
46
155
55
226
3.59
10.83
2.9
2.3
—
—
—
0
0
20
38
6.09
10.51
7.5
7.8
—
—
—
0
0
15
21
8.00
10.38
1.3
1.4
—
—
—
0
0
33
103
4.01
9.62
1.8
2.3
10.6
5.4
umol/l
0.43
28
85
52
220
3.36
9.58
4.2
2.9
6.3
8.2
mmol/l
2.09
45
192
66
323
3.25
9.52
4.1
2.9
42.5
62.4
e6/l
0.29
45
199
56
249
3.29
9.49
5.8
5.8
—
—
—
0
0
41
157
3.42
8.76
2.0
2.2
513.3
569.0
mosm/kgh2o
0.57
30
129
55
253
3.12
8.64
3.0
2.4
15.3
69.6
e6/l
1.35
46
189
39
148
3.39
8.42
5.5
4.0
—
—
—
0
0
81
472
3.10
8.22
2.9
2.1
—
—
—
0
0
48
211
3.09
8.07
2.3
1.5
—
—
—
0
0
32
111
3.54
7.90
1.8
1.9
—
—
—
0
0
70
388
2.87
7.59
2.2
1.7
—
—
—
0
0
41
172
3.08
7.39
2.0
2.2
16.9
14.2
e6/l
0.15
33
147
10
6
17.96
6.87
1.3
1.0
—
—
—
0
0
27
93
3.44
6.67
1.7
1.3
—
—
—
0
0
17
49
3.87
5.39
4.5
2.6
—
—
—
0
0
27
113
2.78
4.72
1.3
1.5
—
—
—
0
0
65
413
2.22
4.50
4.7
2.7
—
—
—
0
0
11
26
4.55
4.46
1.2
1.0
—
—
—
0
0
26
110
2.73
4.44
1.2
1.4
—
—
—
0
0
26
110
2.73
4.44
1.2
1.4
—
—
—
0
0
49
280
2.25
4.38
3.5
2.1
—
—
—
0
0
41
218
2.32
4.34
3.9
3.0
—
—
—
0
0
9
13
7.37
4.24
1.9
1.5
—
—
—
0
0
27
120
2.60
4.18
2.9
2.4
48.4
289.7
ng/l
0.49
12
43
21
434
0.38
4.15
1.5
2.0
—
—
—
0
0
73
503
2.11
3.93
5.7
3.6
6.6
6.1
mmol/l
0.50
67
433
12
34
3.80
3.87
1.8
3.9
24.3
25.0
mmol/l
0.27
12
34
10
289
0.29
3.84
2.3
4.3
—
—
—
0
0
6
5
12.51
3.80
1.3
1.0
71.2
70.4
%
—
6
5
10
25
4.27
3.78
1.2
1.0
—
—
—
0
0
52
322
2.07
3.67
1.7
1.7
96.6
98.2
pmol/l
0.08
18
183
118
1039
4.34
3.65
21.1
10.1
39.4
39.8
%
0.43
106
899
52
323
2.06
3.63
4.8
5.1
—
—
—
0
0
9
246
0.32
3.59
1.4
1.6
—
—
—
0
0
82
604
2.07
3.53
11.0
7.9
4.2
4.0
e9/l
0.41
64
534
66
455
1.97
3.37
6.2
7.2
0.0
0.0
e9/l
0.50
48
367
77
567
1.96
3.17
2.6
2.5
—
—
—
0
0
89
690
2.05
3.15
6.3
3.9
—
28.4
—
0
10
12
40
3.22
3.06
1.5
1.8
—
—
—
0
0
113
972
3.00
3.00
15.8
8.2
138.8
139.5
mmol/l
3.22
108
938
113
973
2.98
2.97
15.0
8.2
3.9
3.9
mmol/l
0.17
108
933
37
219
1.99
2.85
5.2
4.8
1.1
1.0
inr
—
8
85
16
326
0.41
2.82
2.8
2.5
—
—
—
0
0
21
100
2.33
2.78
1.4
1.6
1306.2
1055.7
nmol/l
0.39
12
79
8
21
4.00
2.51
21.4
12.6
0.7
0.7
%
—
8
21
8
21
4.00
2.51
21.4
12.6
1.0
0.9
%
—
8
21
20
98
2.24
2.48
1.3
1.2
—
—
—
0
0
8
22
3.81
2.41
7.9
2.0
0.7
0.7
%
—
8
22
8
22
3.81
2.41
21.4
12.2
95.8
95.7
%
—
8
22
8
23
3.64
2.31
1.8
2.2
—
—
—
0
0
45
302
1.77
2.30
1.8
2.0
—
—
—
0
0
6
13
4.79
2.30
1.7
1.2
—
—
—
0
0
7
18
4.06
2.29
4.3
2.3
13.1
16.7
u/ml
—
7
18
14
277
0.44
2.23
4.6
3.1
0.0
0.0
estimate
—
6
114
8
24
3.49
2.22
7.9
1.9
2.3
1.3
%
—
8
24
113
1007
2.50
2.13
4.6
5.0
1.7
1.6
mu/l
0.20
103
962
8
27
3.10
1.97
7.9
2.6
134.9
128.8
g/l
—
8
27
49
350
1.66
1.95
1.7
1.7
—
—
—
0
0
19
101
2.04
1.94
2.1
1.4
—
—
—
0
0
68
529
1.64
1.93
5.5
5.0
0.5
0.5
e9/l
0.44
54
472
7
22
3.31
1.91
1.1
1.4
—
—
—
0
0
70
551
1.63
1.88
5.5
5.4
0.2
0.2
e9/l
0.27
57
502
68
532
1.62
1.86
5.5
5.0
0.0
0.0
e9/l
0.09
55
471
5
12
4.29
1.84
18.0
17.3
1429.8
1981.8
nmol/l
—
5
12
8
29
2.88
1.82
1.0
1.4
—
—
—
0
0
53
398
1.58
1.68
1.6
1.8
—
—
—
0
0
38
264
1.64
1.65
2.8
2.2
48.7
54.1
u/l
0.51
32
250
105
935
1.84
1.59
3.8
3.1
6.0
5.6
mmol/l
1.42
94
883
9
177
0.47
1.56
1.3
1.2
—
—
—
0
0
87
743
1.58
1.50
5.6
3.9
—
—
—
0
0
35
246
1.59
1.43
1.9
1.7
0.8
0.7
mg/l
0.08
23
180
114
1056
2.09
1.43
15.5
9.8
28.7
17.7
mg/l
1.76
91
784
68
554
1.51
1.42
5.6
5.0
2.1
2.0
e9/l
0.78
57
503
17
100
1.81
1.31
1.4
1.4
378.9
260.7
mu/l
0.46
17
89
5
19
2.70
1.23
1.2
1.5
—
—
—
0
0
0
35
0.00
1.17
0.0
1.2
—
—
—
0
0
12
67
1.88
1.09
1.0
1.2
—
—
—
0
0
118
1122
2.27
1.07
11.6
9.0
—
—
—
0
0
38
289
1.46
1.07
1.2
1.4
2.9
2.0
g/l
1.46
17
196
9
46
2.03
1.06
1.6
1.7
—
—
—
0
0
19
125
1.62
1.01
1.2
1.2
—
—
—
0
0
97
879
1.49
1.00
3.4
4.5
13.3
14.2
pmol/l
4.15
89
832
0
29
0.00
0.99
0.0
1.0
—
0.6
—
0
13
10
57
1.82
0.86
1.1
1.4
—
—
—
0
0
6
32
1.92
0.83
1.0
1.3
—
—
—
0
0
0
25
0.00
0.80
0.0
1.2
—
30.6
—
0
20
5
23
2.22
0.77
2.4
3.0
—
—
—
0
0
7
38
1.89
0.75
1.0
1.1
—
—
—
0
0
10
61
1.70
0.71
1.1
1.3
—
—
—
0
0
6
105
0.55
0.65
3.7
3.0
—
—
—
0
0
0
20
0.00
0.61
0.0
1.2
—
—
—
0
0
6
37
1.65
0.56
1.0
1.1
—
—
—
0
0
9
131
0.66
0.55
1.7
1.7
—
—
—
0
0
6
38
1.61
0.55
1.8
3.8
—
7.4
—
0
5
18
230
0.75
0.49
1.4
1.3
13.5
23.9
iu/ml
—
5
68
51
449
1.23
0.49
2.0
1.9
—
—
—
0
0
86
801
1.24
0.48
4.6
3.6
35.5
36.9
mmol/mol
0.67
80
771
6
95
0.61
0.44
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
135.8
—
0
10
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
17
138
1.27
0.32
1.4
1.3
24.2
22.8
iu/l
—
10
124
7
98
0.70
0.32
2.0
2.2
—
18.4
—
0
8
7
53
1.34
0.31
5.9
2.8
—
—
—
0
0
15
121
1.27
0.30
1.2
1.2
—
—
—
0
0
28
247
1.17
0.25
1.8
1.9
2.0
2.5
mg/l
0.90
23
214
9
76
1.20
0.25
1.1
1.1
—
—
—
0
0
5
40
1.26
0.22
1.2
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
38.7
—
0
10
0
12
0.00
0.21
0.0
2.4
—
1.5
—
0
5
0
12
0.00
0.21
0.0
5.8
—
111.5
—
0
5
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
55
520
1.10
0.17
3.8
2.9
0.0
0.0
estimate
—
6
114
18
159
1.15
0.16
3.5
4.1
6.6
17.2
mg/mmol
0.82
11
105
14
121
1.18
0.16
1.1
1.1
—
—
—
0
0
16
180
0.87
0.14
2.3
2.2
130.2
65.8
ug/g
0.36
11
137
94
960
0.91
0.12
2.9
3.0
1.5
1.5
mmol/l
0.54
85
918
13
146
0.88
0.11
2.5
2.2
6773.1
6470.5
u/l
—
7
62
54
522
1.06
0.08
3.9
3.0
0.0
0.0
estimate
—
6
110
18
166
1.10
0.08
1.8
2.8
—
—
—
0
0
17
157
1.10
0.07
3.2
3.4
41.9
121.2
mg/l
—
10
105
7
82
0.84
0.07
1.0
1.3
77.5
408.4
u/ml
—
7
75
95
964
0.94
0.07
3.0
3.0
4.6
4.8
mmol/l
0.63
87
920
11
99
1.12
0.06
1.5
1.2
—
—
—
0
0
98
967
1.07
0.06
3.3
3.1
2.9
2.9
mmol/l
0.00
91
920
25
238
1.06
0.05
2.1
2.6
25.0
11.9
ng/l
—
10
76
10
109
0.91
0.04
2.1
1.8
416.3
385.4
nmol/l
—
10
104
18
183
0.98
0.00
1.8
2.3
—
—
—
0
0
52
517
1.01
0.00
6.3
4.2
0.0
0.0
estimate
—
5
115
10
102
0.98
0.00
1.0
1.4
—
—
—
0
0
91
914
0.98
0.00
2.5
2.7
1.2
1.2
mmol/l
0.41
82
868
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
3.8
—
0
7
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
8.3
—
0
7
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
6
62
0.97
0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.8
—
72.8
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
104.9
—
0
7
0
9
0.00
0.00
0.0
1.4
—
2.0
—
0
9
0
9
0.00
0.00
0.0
2.8
—
6.4
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
2110.0
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
506.6
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
8
81
0.99
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
1.4
—
0
5
0
9
0.00
0.00
0.0
2.8
—
1.0
—
0
9
0
5
0.00
0.00
0.0
14.2
—
—
—
0
0
5
56
0.89
0.00
4.2
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
25.3
—
0
6
0
6
0.00
-0.00
0.0
2.3
—
0.3
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
91.8
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint MATERNCAREFETUSALCO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have MATERNCAREFETUSALCO.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: MATERNCAREFETUSALCO – Maternal care for (suspected) damage to fetus from alcohol

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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