No definition available.
Other congenital malformations of heart
DOID EFO Endpoint Browser PheWeb
Q17_OTHER_CONGEN_MALFO_HEART
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
246 |
4. Check minimum number of eventsNone |
246 |
5. Include endpointsNone |
246 |
6. Filter based on genotype QC (FinnGen only) |
246 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_CIRCULATO_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q2
- Name in latin
- Aliae malformationes congenitae cordis
Similar endpoints
↥List of similar endpoints to
Other congenital malformations of heart
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations of the circulatory system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Congenital malformations, deformations and chromosomal abnormalities
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2325 | 1187 | 1135 |
| Only index persons | 1745 | 915 | 830 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 10.16 | 13.47 | 6.64 |
| Only index persons | 16.61 | 21.73 | 10.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 246 | 145 | 101 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | 20.25 | 23.75 | 15.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 223
- Matched controls
- 2228
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
42.7
58.9
73
25
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
52.5
56.6
67
18
201
Kela drug reimbursment
Chronic cardiac insufficiency
38.5
53.6
68
25
Q24.6
ICD-10 Finland
Congenital heart block
+∞
53.3
49
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
49.9
46
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
12.8
47.2
93
118
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
10.1
47.1
111
198
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
33.5
42.8
56
22
XF400
NOMESCO Finland
ECG with 12 standard connections
8.5
39.5
103
205
XF404
NOMESCO Finland
Ambulatory ECG
14.3
39.1
70
69
B01AA03
ATC
warfarin; systemic
13.2
38.1
71
76
C03CA01
ATC
furosemide; systemic
9.5
37.3
86
138
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
117.5
37.1
39
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
+∞
36.5
34
*
FM2CE
NOMESCO Finland
NA
17.0
35.5
58
45
Q24.0
ICD-10 Finland
Dextrocardia
+∞
35.3
33
*
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
35.3
33
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
42.7
34.2
42
12
C03DA01
ATC
spironolactone; oral
13.7
33.3
60
58
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
32.0
30
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
21.1
30.9
46
27
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
+∞
29.9
28
*
Q21.10
ICD-10 Finland
Persistent ostium secundum
+∞
29.9
28
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
8.8
27.4
63
95
61
HP
Catheterization and pressure measurement of the left side of the heart
110.5
27.4
29
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
21.9
27.3
40
22
31
HP
Congenital heart failure surgery
+∞
26.6
25
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.8
26.5
127
479
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
+∞
25.5
24
*
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
+∞
25.5
24
*
TPH07
NOMESCO Finland
Cathetrisation of artery
7.8
25.2
63
107
XF402
NOMESCO Finland
ECG with work load test
10.5
25.1
51
61
XF622
NOMESCO Finland
Measurement of minute volume of heart
63.6
24.7
28
5
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
63.6
24.7
28
5
I44.2
ICD-10 Finland
Atrioventricular block, complete
41.3
23.6
29
8
62
HP
Catheterization and pressure measurement of the right side of the heart
255.0
23.1
23
*
Q25.0
ICD-10 Finland
Patent ductus arteriosus
+∞
22.3
21
*
Q25.1
ICD-10 Finland
Coarctation of aorta
+∞
22.3
21
*
Q20.48
ICD-10 Finland
Single ventricle
+∞
22.3
21
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.0
21.4
65
142
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.3
21.1
49
73
C01AA05
ATC
digoxin; systemic
17.4
21.0
33
22
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
20.1
19
*
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
115.3
19.9
21
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.0
19.3
103
395
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
19.0
18
*
Q24.58
ICD-10 Finland
Malformation of coronary vessels
+∞
19.0
18
*
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
57.6
18.3
21
*
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
+∞
17.9
17
*
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
54.6
17.3
20
*
207
Kela drug reimbursment
Chronic arrhythmias
8.6
17.1
38
52
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
+∞
16.9
16
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
43.7
16.6
20
5
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.8
16.2
86
318
C07AB07
ATC
bisoprolol; oral
3.7
16.0
86
322
Z98.8
ICD-10 Finland
Other specified postsurgical states
28.7
15.9
21
8
Q23.11
ICD-10 Finland
Bicuspid aortic valve
+∞
15.8
15
*
Q24.50
ICD-10 Finland
Congenital coronary artery-coronary fistula
+∞
15.8
15
*
XF600
NOMESCO Finland
Bloodpressure measurement
5.5
15.4
48
105
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
6.1
15.1
43
84
Q23.4
ICD-10 Finland
Hypoplastic left heart syndrome
+∞
14.7
14
*
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
14.7
14
*
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
24.2
14.5
20
9
WX882
NOMESCO Finland
High dependency care
5.6
13.9
42
88
G04BE03
ATC
sildenafil; oral
80.2
13.7
15
*
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
+∞
13.7
13
*
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
+∞
13.7
13
*
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
13.7
13
*
R4110
NOMESCO Finland
Physiotherapy
3.3
13.6
88
371
R07.4
ICD-10 Finland
Chest pain, unspecified
3.8
13.1
62
205
WX704
NOMESCO Finland
Intubation
6.1
11.9
33
62
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
+∞
11.6
11
*
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
+∞
11.6
11
*
I50.9
ICD-10 Finland
Heart failure, unspecified
6.5
11.5
30
52
I47.2
ICD-10 Finland
Ventricular tachycardia
15.2
10.7
17
12
C07AB02
ATC
metoprolol; systemic
4.0
10.5
44
129
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
11.4
10.5
19
18
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
+∞
10.5
10
*
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
+∞
10.5
10
*
FAE30
NOMESCO Finland
Total cavo-pulmonary connection using fenestrated patch
+∞
10.5
10
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
+∞
10.5
10
*
FDA00
NOMESCO Finland
Aortoplasty and aorto-pulmonary shunt for HLHS
+∞
10.5
10
*
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
+∞
10.5
10
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
10.5
10
*
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
+∞
10.5
10
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.4
10.5
57
207
RS224
NOMESCO Finland
NA
14.0
10.3
17
13
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
10.3
57
210
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
+∞
9.4
9
*
Q20.40
ICD-10 Finland
Double inlet left ventricle
+∞
9.4
9
*
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
9.4
9
*
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
+∞
9.4
9
*
73
HP
Initial pacemaker installation
+∞
9.4
9
*
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
+∞
9.4
9
*
WX892
NOMESCO Finland
Monitored bed care
4.4
9.1
33
84
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
10.1
8.9
17
18
FPF00
NOMESCO Finland
Implantation of epicardial pacemaker with ventricular electrode
93.4
8.5
9
*
FM1CD
NOMESCO Finland
Very extensive CT of heart
93.4
8.5
9
*
C09AA02
ATC
enalapril; systemic
3.7
8.4
37
113
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
+∞
8.4
8
*
Q21.21
ICD-10 Finland
Atrioventricular duct
+∞
8.4
8
*
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
+∞
8.4
8
*
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
8.4
8
*
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
+∞
8.4
8
*
Q21.0
ICD-10 Finland
Ventricular septal defect
+∞
8.4
8
*
4260A
ICD-9 Finland
Conduction disorders, Atrioventricular block, complete
+∞
8.4
8
*
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
+∞
8.4
8
*
Q26.1
ICD-10 Finland
Persistent left superior vena cava
+∞
8.4
8
*
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
18.0
8.2
12
7
I42.0
ICD-10 Finland
Dilated cardiomyopathy
10.6
8.2
15
15
C07AA07
ATC
sotalol; systemic
23.0
8.1
11
5
I48
ICD-10 Finland
Atrial fibrillation and flutter
4.0
8.0
32
90
Z01.8
ICD-10 Finland
Other specified special examinations
2.8
7.8
56
239
ZXA05
NOMESCO Finland
Left side
2.8
7.8
53
220
TFP20
NOMESCO Finland
Cardiodefibrillation
7.1
7.8
18
27
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
6.9
7.6
18
28
7AX01
NOMESCO Finland
NA
82.7
7.5
8
*
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
7.3
7
*
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
7.3
7
*
74619
ICD-8 Finland
Congenital anomalies of heart, Transposition of great vessels
+∞
7.3
7
*
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
+∞
7.3
7
*
FLE96
NOMESCO Finland
Other repair of outlet obstruction of left ventricle
+∞
7.3
7
*
ZX199
NOMESCO Finland
Other rote
16.4
7.3
11
7
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
31.1
7.2
9
*
Z94.1
ICD-10 Finland
Heart transplant status
31.1
7.2
9
*
XFE00
NOMESCO Finland
Epicardial ultrasonography
10.5
7.1
13
13
I50.1
ICD-10 Finland
Left ventricular failure
10.5
7.1
13
13
ZX120
NOMESCO Finland
Intravenous
3.6
7.0
31
95
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.6
6.9
54
242
R50.9
ICD-10 Finland
Fever, unspecified
2.6
6.9
56
255
I49.5
ICD-10 Finland
Sick sinus syndrome
17.3
6.8
10
6
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
6.7
58
276
WX402
NOMESCO Finland
General anaesthesia
2.5
6.7
55
254
JDB10
NOMESCO Finland
Percutaneous gastrostomy
12.8
6.7
11
9
C01BD01
ATC
amiodarone; systemic
12.8
6.7
11
9
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
6.6
50
222
FM1BD
NOMESCO Finland
Extensive CT of heart
71.8
6.5
7
*
602
Kela drug reimbursment
Children's severe malnutrition
5.7
6.3
17
32
Q89.30
ICD-10 Finland
Situs inversus with dextrocardia
+∞
6.3
6
*
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
+∞
6.3
6
*
FDJ00
NOMESCO Finland
End to end reconstruction of aorta for coarctation
+∞
6.3
6
*
FFK20
NOMESCO Finland
Atrio-pulmonary anastomosis
+∞
6.3
6
*
FLE00
NOMESCO Finland
Excision of subvalvular membrane of left ventricle
+∞
6.3
6
*
Q26.8
ICD-10 Finland
Other congenital malformations of great veins
+∞
6.3
6
*
1EA01
NOMESCO Finland
NA
+∞
6.3
6
*
Q21.19
ICD-10 Finland
Atrial septal defect NOS
+∞
6.3
6
*
I45.8
ICD-10 Finland
Other specified conduction disorders
+∞
6.3
6
*
81
HP
Angiography of the heart and coronary arteries
8.0
6.2
13
17
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.9
6.2
38
147
WX872
NOMESCO Finland
Intensive care
7.0
6.1
14
21
XX3BT
NOMESCO Finland
Other labeling with X-ray guidance
9.0
6.1
12
14
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
7.6
6.0
13
18
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
156
287
13.12
95.58
9.9
3.3
861.1
854.0
ng/l
0.01
149
232
44
17
31.30
64.81
3.8
3.4
76.6
114.4
%
3.36
44
17
96
227
6.30
41.64
8.7
3.1
3001.0
168.1
ng/l
1.49
84
139
57
85
8.43
38.32
4.9
6.7
174.4
171.9
%
0.07
57
85
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
38
34
13.04
37.13
35.3
19.2
0.3
0.3
u/ml
0.55
20
22
123
420
4.86
33.57
3.6
3.1
—
—
—
0
0
100
361
3.98
23.90
6.6
3.4
1.7
1.2
mg/l
0.71
78
282
67
185
4.60
22.95
3.4
3.0
18.8
22.6
%
1.73
62
171
156
778
3.75
22.51
5.0
4.6
—
—
—
0
0
58
147
4.85
22.04
24.3
11.3
0.4
0.5
mmol/l
0.10
48
115
49
111
5.26
21.21
32.4
15.7
2.0
1.3
inr
—
5
20
41
92
5.15
17.82
32.5
10.9
0.6
0.7
%
0.67
41
92
41
93
5.09
17.59
32.5
10.8
1.2
1.4
%
0.47
41
93
129
648
3.08
16.92
8.6
6.8
37.4
36.9
g/l
0.56
123
621
157
884
3.14
16.73
17.0
10.7
1.2
1.2
mmol/l
4.54
152
792
78
322
3.08
14.04
15.2
10.5
1.3
1.2
mmol/l
0.62
73
306
169
1058
2.91
13.70
15.0
6.5
6.2
6.3
mmol/l
0.10
157
968
94
448
2.78
12.83
4.8
3.0
85.5
23.9
ng/l
0.87
55
242
72
309
2.88
11.86
20.6
13.9
24.7
24.7
mmol/l
0.04
72
309
139
840
2.51
11.25
12.9
7.1
20.1
16.3
umol/l
0.72
133
791
89
443
2.58
10.84
3.2
3.0
3.1
3.0
mg/l
0.06
81
391
51
191
3.11
10.62
1.8
1.9
—
—
—
0
0
61
255
2.85
10.43
1.8
2.0
—
—
—
0
0
233
1899
5.29
9.60
31.0
13.2
4.0
4.0
mmol/l
1.55
233
1840
232
1896
4.93
9.27
31.0
13.2
139.4
139.6
mmol/l
0.58
232
1844
48
191
2.88
8.90
1.8
1.8
—
—
—
0
0
66
319
2.46
8.28
10.4
9.5
0.7
1.4
mmol/l
0.82
53
240
134
896
2.09
7.40
3.9
3.1
87.3
71.9
ug/l
0.55
129
841
17
39
4.61
7.08
1.4
1.6
—
—
—
0
0
19
49
4.12
6.85
5.2
12.2
21.0
23.7
mmol/l
3.67
19
43
58
288
2.33
6.74
16.7
9.0
1.6
0.7
mmol/l
2.05
46
207
58
292
2.29
6.51
16.8
8.9
4.9
5.0
kpa
0.93
58
274
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
10
8
12.96
6.13
1.3
1.4
119.1
124.8
%
—
10
8
65
357
2.12
5.84
3.5
3.3
1.0
0.7
e6/l
0.73
37
201
14
35
4.18
5.24
1.2
1.0
1.5
1.5
u/ml
—
6
15
17
51
3.51
4.98
7.6
13.2
—
3087.1
—
0
8
229
2013
2.99
4.92
22.0
11.8
23.2
22.0
mg/l
0.25
192
1440
87
559
1.86
4.88
4.6
3.7
0.4
0.3
e6/l
0.20
66
397
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
8
7
11.76
4.82
1.8
1.0
80.0
148.3
%
—
8
7
97
655
1.79
4.57
5.1
4.0
—
—
—
0
0
25
105
2.54
4.14
2.6
2.6
77.0
80.0
ml/min/173m2
—
9
45
12
33
3.77
3.97
1.0
1.0
—
—
—
0
0
79
530
1.72
3.67
4.5
3.2
2.4
2.4
mmol/l
0.12
74
485
57
348
1.83
3.65
3.6
3.4
3.4
2.4
e6/l
0.37
30
193
6
6
10.21
3.51
6.3
10.5
1.2
1.3
mmol/l
—
6
6
177
1475
1.71
3.51
15.4
9.1
97.2
93.9
ml/min/173m2
1.07
145
1102
119
900
1.62
3.45
5.8
4.8
0.0
0.0
estimate
0.00
17
163
119
901
1.62
3.42
4.1
3.4
0.0
0.0
estimate
0.00
18
160
17
65
2.74
3.38
2.3
2.4
—
—
—
0
0
17
65
2.74
3.38
2.1
2.1
—
—
—
0
0
119
908
1.60
3.27
4.1
3.4
0.0
0.0
estimate
0.00
17
157
9
19
4.87
3.27
3.7
5.6
—
—
—
0
0
20
88
2.39
3.03
1.7
1.6
—
—
—
0
0
154
1269
1.57
2.91
11.9
11.7
3.8
3.7
e9/l
0.05
141
1074
24
117
2.16
2.88
1.5
1.7
—
—
—
0
0
12
45
2.75
2.49
5.0
4.9
—
—
—
0
0
9
27
3.42
2.41
1.6
1.7
—
—
—
0
0
9
28
3.30
2.33
1.4
1.3
—
—
—
0
0
64
452
1.56
2.32
4.2
3.7
0.0
0.0
estimate
0.50
18
157
12
47
2.63
2.30
1.5
1.9
—
—
—
0
0
13
54
2.49
2.24
1.8
2.0
—
—
—
0
0
85
647
1.48
2.16
4.2
3.3
—
—
—
0
0
11
43
2.63
2.12
1.3
2.0
—
—
—
0
0
26
148
1.85
2.08
5.7
6.7
—
—
—
0
0
7
20
3.57
2.07
2.3
1.3
—
—
—
0
0
7
20
3.57
2.07
1.0
1.0
85.1
95.6
%
—
7
20
239
2293
2.49
1.87
37.3
17.6
134.3
135.1
g/l
0.35
239
2266
8
32
2.55
1.61
1.6
1.4
—
—
—
0
0
7
26
2.74
1.59
1.3
2.2
—
—
—
0
0
17
97
1.81
1.39
4.0
4.6
1.2
1.2
mmol/l
0.11
17
85
17
97
1.81
1.39
2.4
2.1
204.2
168.8
u/ml
0.17
12
52
89
745
1.30
1.18
3.7
2.8
72.8
71.8
nmol/l
0.12
84
687
7
31
2.29
1.11
1.6
2.1
—
—
—
0
0
215
2036
1.44
1.11
15.3
9.2
28.1
25.7
u/l
1.62
215
1970
8
41
1.98
1.10
1.8
1.9
—
—
—
0
0
172
1578
1.30
1.08
4.6
3.5
1.4
1.5
mmol/l
1.63
172
1485
151
1370
1.26
1.00
4.4
4.3
7.7
9.1
mm/h
1.25
143
1284
5
23
2.20
0.98
3.4
2.0
23.8
28.5
umol/l
—
5
23
16
101
1.62
0.96
2.4
2.1
—
—
—
0
0
9
52
1.76
0.93
1.0
1.3
—
—
—
0
0
9
52
1.76
0.93
1.9
2.3
—
—
—
0
0
15
94
1.63
0.93
1.5
1.4
—
—
—
0
0
15
94
1.63
0.93
1.5
1.4
—
—
—
0
0
15
94
1.63
0.93
1.5
1.4
—
—
—
0
0
15
94
1.63
0.93
1.5
1.4
—
—
—
0
0
12
191
0.61
0.88
1.0
1.5
—
—
—
0
0
8
45
1.80
0.85
1.0
1.5
—
—
—
0
0
15
98
1.57
0.80
1.3
1.3
—
—
—
0
0
15
221
0.66
0.80
1.1
1.1
—
—
—
0
0
6
33
1.84
0.79
1.0
1.2
—
—
—
0
0
10
59
1.72
0.77
2.2
1.4
—
—
—
0
0
10
59
1.72
0.77
2.2
1.4
—
—
—
0
0
9
53
1.72
0.76
1.9
1.6
—
—
—
0
0
17
117
1.49
0.74
1.9
1.4
—
—
—
0
0
7
39
1.82
0.73
1.9
1.9
—
—
—
0
0
208
1991
1.29
0.71
36.7
14.1
39.3
40.0
%
0.91
183
1691
16
110
1.49
0.70
2.6
1.8
—
—
—
0
0
160
1492
1.21
0.70
4.2
3.8
15.2
14.5
pmol/l
2.55
155
1391
22
288
0.74
0.63
1.3
1.2
1.0
9.9
u/ml
2.44
12
113
61
702
0.83
0.62
1.5
1.6
0.6
3.0
u/ml
3.13
14
144
8
51
1.59
0.61
1.9
2.1
—
—
—
0
0
8
54
1.50
0.58
1.3
1.6
—
—
—
0
0
5
86
0.57
0.57
1.2
1.6
—
—
—
0
0
18
133
1.38
0.57
3.2
2.9
—
—
—
0
0
15
109
1.40
0.52
1.5
1.5
—
—
—
0
0
6
40
1.51
0.52
2.8
1.6
—
—
—
0
0
23
181
1.30
0.50
1.5
1.5
—
—
—
0
0
7
107
0.64
0.50
3.1
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.5
—
64.0
—
0
15
0
16
0.00
0.41
0.0
5.4
—
21.8
—
0
16
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
9
69
1.32
0.37
1.6
2.6
—
—
—
0
0
6
41
1.47
0.36
2.8
1.8
—
—
—
0
0
26
222
1.19
0.31
3.5
3.7
23.9
23.6
%
0.04
12
92
5
74
0.67
0.26
1.6
1.6
—
—
—
0
0
57
528
1.10
0.23
2.0
1.7
82.1
96.8
pmol/l
2.09
32
268
5
41
1.22
0.22
1.6
1.6
0.3
0.3
nmol/l
—
5
34
37
407
0.89
0.22
2.3
2.2
—
—
—
0
0
35
316
1.13
0.22
1.5
1.4
18.9
21.3
nmol/l
0.55
30
267
5
42
1.19
0.21
1.2
1.4
0.4
33.9
u/ml
—
5
32
5
42
1.19
0.21
1.4
2.5
—
—
—
0
0
8
103
0.77
0.21
1.4
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
8
105
0.75
0.21
2.1
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
4.8
—
24.0
—
0
12
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
2.8
—
0
6
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
17
148
1.16
0.17
3.1
2.1
9.3
16.6
iu/l
1.29
11
114
5
68
0.73
0.17
1.6
1.4
—
—
—
0
0
9
78
1.16
0.15
1.2
1.3
—
—
—
0
0
32
295
1.10
0.15
1.5
1.4
—
—
—
0
0
12
103
1.17
0.14
1.1
1.2
—
—
—
0
0
23
209
1.11
0.13
2.0
1.8
—
—
—
0
0
13
148
0.87
0.13
1.2
1.3
—
—
—
0
0
11
95
1.17
0.12
1.2
1.3
—
—
—
0
0
14
157
0.89
0.11
1.3
1.3
146.1
179.6
iu/ml
—
5
60
181
1784
1.06
0.11
4.0
3.9
—
—
—
0
0
68
706
0.95
0.11
2.0
1.9
—
—
—
0
0
6
58
1.04
0.08
1.2
1.2
—
—
—
0
0
6
58
1.04
0.08
2.0
1.9
—
—
—
0
0
6
71
0.84
0.07
1.3
1.2
—
—
—
0
0
6
73
0.82
0.07
1.3
1.2
—
—
—
0
0
121
1224
0.98
0.04
4.4
3.4
54.4
36.5
u/l
2.08
116
1178
43
442
0.97
0.04
2.5
2.4
—
—
—
0
0
158
1567
1.02
0.03
4.5
3.4
5.8
5.7
mmol/l
0.78
150
1450
30
293
1.03
0.01
1.2
1.3
11.3
29.1
iu/ml
—
6
81
18
174
1.04
0.00
1.9
2.5
0.5
0.8
ug/l
2.98
12
101
26
263
0.99
0.00
2.4
1.9
—
—
—
0
0
11
106
1.04
0.00
1.0
1.4
186.2
330.5
miu/ml
—
5
52
5
57
0.87
0.00
1.4
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
95.7
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
220.8
—
0
6
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
7.8
—
0
8
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_CONGEN_MALFO_HEART and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_HEART | 2.577 [1.84, 3.61] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.577 |
During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 1004 females with Q17_OTHER_CONGEN_MALFO_HEART died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_HEART | 2.584 [1.86, 3.59] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 936 males with Q17_OTHER_CONGEN_MALFO_HEART died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_CONGEN_MALFO_HEART.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.232% | 0.548% |
| 5 | 1.526% | 2.633% |
| 10 | 3.708% | 6.778% |
| 15 | 7.36% | 13.206% |
| 20 | 13.075% | 20.453% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_CONGEN_MALFO_HEART – Other congenital malformations of heart
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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