No definition available.
Other congenital malformations of heart
DOID EFO Endpoint Browser PheWeb
Q17_OTHER_CONGEN_MALFO_HEART
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
255 |
4. Check minimum number of eventsNone |
255 |
5. Include endpointsNone |
255 |
6. Filter based on genotype QC (FinnGen only) |
236 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_CIRCULATO_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q2
- Name in latin
- Aliae malformationes congenitae cordis
Similar endpoints
↥List of similar endpoints to
Other congenital malformations of heart
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations of the circulatory system
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Congenital malformations, deformations and chromosomal abnormalities
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2325 | 1187 | 1135 |
| Only index persons | 1745 | 915 | 830 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 10.16 | 13.47 | 6.64 |
| Only index persons | 16.61 | 21.73 | 10.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 236 | 139 | 97 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | 23.23 | 27.53 | 17.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 255
- Matched controls
- 2548
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
63.1
137.6
79
18
201
Kela drug reimbursment
Chronic cardiac insufficiency
64.7
130.1
74
16
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
34.8
127.6
88
38
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
48.7
99.6
60
16
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
13.3
92.3
116
150
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
12.0
92.0
144
248
XF404
NOMESCO Finland
Ambulatory ECG
18.4
89.7
82
64
B01AA03
ATC
warfarin; systemic
17.4
89.5
85
71
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
61.9
88.1
50
10
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
35.6
85.2
56
20
FM2CE, ,
NOMESCO Finland
18.4
68.7
60
42
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
30.1
68.2
47
19
XF400
NOMESCO Finland
ECG with 12 standard connections
9.4
67.3
109
187
TPH07
NOMESCO Finland
Cathetrisation of artery
10.6
63.0
84
113
C03CA01
ATC
furosemide; systemic
8.9
63.0
105
185
C03DA01
ATC
spironolactone; oral
12.7
62.5
70
74
Q24.6
ICD-10 Finland
Congenital heart block
+∞
58.6
54
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
58.6
54
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
9.1
55.8
84
130
XF402
NOMESCO Finland
ECG with work load test
11.9
52.8
60
64
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.3
48.7
62
77
ZXE20
NOMESCO Finland
More than three and less than five hours
7.8
47.5
82
146
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.8
43.4
158
557
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
242.8
41.1
41
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.2
40.0
89
202
Q24.0
ICD-10 Finland
Dextrocardia
+∞
38.5
36
*
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
37.4
35
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
+∞
37.4
35
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
8.5
37.1
54
78
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
35.2
33
*
207
Kela drug reimbursment
Chronic arrhythmias
9.2
35.2
47
61
Q21.10
ICD-10 Finland
Persistent ostium secundum
+∞
34.1
32
*
Z2221
NOMESCO Finland
Medical doctor
4.7
33.2
129
457
XF600
NOMESCO Finland
Bloodpressure measurement
7.3
32.7
55
93
I44.2
ICD-10 Finland
Atrioventricular block, complete
69.4
32.0
36
6
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
+∞
31.9
30
*
61
HP
Catheterization and pressure measurement of the left side of the heart
97.7
31.6
34
*
31
HP
Congenital heart failure surgery
+∞
30.8
29
*
XF622
NOMESCO Finland
Measurement of minute volume of heart
340.3
30.5
30
*
ZXD10
NOMESCO Finland
Scheduled procedure
4.4
30.1
148
614
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
+∞
29.8
28
*
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
+∞
28.7
27
*
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
48.7
28.5
34
8
ZXE30
NOMESCO Finland
More than five and less than seven hours
8.0
28.5
42
61
Q20.48
ICD-10 Finland
Single ventricle
+∞
27.6
26
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.0
26.3
115
430
ZXE10
NOMESCO Finland
More than one and less than three hours
3.9
25.7
128
522
C01AA05
ATC
digoxin; systemic
24.4
25.6
36
17
Q25.1
ICD-10 Finland
Coarctation of aorta
+∞
25.4
24
*
Q24.58
ICD-10 Finland
Malformation of coronary vessels
+∞
25.4
24
*
Q25.0
ICD-10 Finland
Patent ductus arteriosus
+∞
24.3
23
*
62
HP
Catheterization and pressure measurement of the right side of the heart
263.5
24.1
24
*
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
+∞
23.3
22
*
ZXD05
NOMESCO Finland
Urgent procedure
3.7
22.8
114
459
I50.9
ICD-10 Finland
Heart failure, unspecified
7.2
22.5
36
57
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
6.4
22.1
40
72
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
88.0
22.1
24
*
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
239.5
21.9
22
*
R4110
NOMESCO Finland
Physiotherapy
3.6
21.4
110
448
C07AB07
ATC
bisoprolol; oral
3.5
21.2
109
443
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
+∞
21.1
20
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
119.8
20.9
22
*
WX704
NOMESCO Finland
Intubation
5.7
20.7
43
88
WX882
NOMESCO Finland
High dependency care
5.4
20.2
44
94
I48
ICD-10 Finland
Atrial fibrillation and flutter
5.5
20.2
43
90
Q24.50
ICD-10 Finland
Congenital coronary artery-coronary fistula
+∞
19.0
18
*
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
+∞
19.0
18
*
Q23.11
ICD-10 Finland
Bicuspid aortic valve
+∞
19.0
18
*
Z98.8
ICD-10 Finland
Other specified postsurgical states
41.8
18.9
23
6
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
31.4
17.7
23
8
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
34.2
17.3
22
7
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.2
17.0
92
378
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
+∞
16.8
16
*
C09AA02
ATC
enalapril; systemic
4.5
16.6
45
115
R07.4
ICD-10 Finland
Chest pain, unspecified
3.4
16.5
77
288
Z3231
NOMESCO Finland
Registered nurse
3.0
16.5
116
552
G04BE03
ATC
sildenafil; oral
64.2
16.0
18
*
WX892
NOMESCO Finland
Monitored bed care
4.6
15.8
41
101
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.5
15.8
69
247
Z01.8
ICD-10 Finland
Other specified special examinations
3.2
15.0
74
285
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.4
15.0
67
243
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
26.9
14.9
20
8
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
14.7
14
*
Q23.4
ICD-10 Finland
Hypoplastic left heart syndrome
+∞
14.7
14
*
FDF05
NOMESCO Finland
Percutaneous transluminal occlusion of aorto-pulmonary collaterals
+∞
14.7
14
*
Q20.1
ICD-10 Finland
Double outlet right ventricle
+∞
14.7
14
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
13.1
13.9
24
20
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
+∞
13.7
13
*
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
13.7
13
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
11.4
13.6
25
24
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
4.0
13.0
41
117
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
73.6
12.7
14
*
I47.2
ICD-10 Finland
Ventricular tachycardia
21.4
12.6
18
9
FAE10
NOMESCO Finland
Bidirectional anastomosis between superior vena cava and pulmonary artery
+∞
12.6
12
*
Q20.40
ICD-10 Finland
Double inlet left ventricle
+∞
12.6
12
*
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
+∞
12.6
12
*
I42.0
ICD-10 Finland
Dilated cardiomyopathy
28.3
12.2
16
6
WX402
NOMESCO Finland
General anaesthesia
2.8
12.1
84
386
ZXE00
NOMESCO Finland
One hour or less
2.5
12.0
127
717
R50.9
ICD-10 Finland
Fever, unspecified
2.8
11.6
72
311
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
11.6
64
260
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
+∞
11.5
11
*
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
+∞
11.5
11
*
FDA00
NOMESCO Finland
Aortoplasty and aorto-pulmonary shunt for HLHS
+∞
11.5
11
*
FAE30
NOMESCO Finland
Total cavo-pulmonary connection using fenestrated patch
+∞
11.5
11
*
4260A
ICD-9 Finland
Conduction disorders, Atrioventricular block, complete
+∞
11.5
11
*
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
+∞
11.5
11
*
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
+∞
11.5
11
*
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
+∞
11.5
11
*
73
HP
Initial pacemaker installation
125.3
11.5
12
*
C07AB02
ATC
metoprolol; systemic
3.3
11.2
48
168
C09AA05
ATC
ramipril; oral
3.3
11.0
46
158
RS224, ,
NOMESCO Finland
15.1
10.6
17
12
Q22.0
ICD-10 Finland
Pulmonary valve atresia
+∞
10.5
10
*
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
+∞
10.5
10
*
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
10.5
10
*
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
+∞
10.5
10
*
Q26.1
ICD-10 Finland
Persistent left superior vena cava
+∞
10.5
10
*
C07AA07
ATC
sotalol; systemic
19.8
10.4
15
8
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
41.8
10.0
12
*
XFE00
NOMESCO Finland
Epicardial ultrasonography
17.6
10.0
15
9
TFP20
NOMESCO Finland
Cardiodefibrillation
8.4
9.8
21
27
C01BD01
ATC
amiodarone; systemic
22.7
9.4
13
6
FPF00
NOMESCO Finland
Implantation of epicardial pacemaker with ventricular electrode
+∞
9.4
9
*
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
+∞
9.4
9
*
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
+∞
9.4
9
*
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
+∞
9.4
9
*
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
+∞
9.4
9
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.1
9.4
45
167
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
3.3
9.4
39
133
Z2446
NOMESCO Finland
Social worker
3.0
9.3
46
174
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
7.9
9.1
20
27
I47.1
ICD-10 Finland
Supraventricular tachycardia
5.2
9.0
19
39
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
5.0
9.0
20
43
I49.5
ICD-10 Finland
Sick sinus syndrome
11.3
8.9
16
15
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
4.7
8.8
21
48
AN1
HP
Coronary angiography
4.6
8.6
21
49
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
28.6
8.5
11
*
I44.1
ICD-10 Finland
Atrioventricular block, second degree
28.6
8.5
11
*
ZXA05
NOMESCO Finland
Left side
2.6
8.5
58
260
WZC30
NOMESCO Finland
Teaching
2.9
8.5
44
171
FPJ04
NOMESCO Finland
Revision of pacemaker generator with atrial and ventricular electrodes
92.9
8.5
9
*
FM1CD
NOMESCO Finland
Very extensive CT of heart
92.9
8.5
9
*
I50.1
ICD-10 Finland
Left ventricular failure
11.3
8.4
15
14
Q89.30
ICD-10 Finland
Situs inversus with dextrocardia
+∞
8.4
8
*
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
8.4
8
*
Q21.21
ICD-10 Finland
Atrioventricular duct
+∞
8.4
8
*
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
+∞
8.4
8
*
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
+∞
8.4
8
*
WX872
NOMESCO Finland
Intensive care
8.0
8.3
18
24
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.8
8.3
19
42
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
12.3
8.2
14
12
I49.3
ICD-10 Finland
Ventricular premature depolarization
4.1
8.2
23
60
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.4
8.0
64
308
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.4
8.0
30
96
I35.0
ICD-10 Finland
Aortic (valve) stenosis
10.5
7.6
14
14
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
8.0
7.5
16
21
Z3226
NOMESCO Finland
Physiotherapist
2.3
7.5
68
346
FM1BD
NOMESCO Finland
Extensive CT of heart
82.3
7.5
8
*
ZX120
NOMESCO Finland
Intravenous
3.1
7.4
33
117
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.2
7.4
31
106
R04.0
ICD-10 Finland
Epistaxis
4.1
7.4
21
55
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
11.3
7.4
13
12
K84
ICPC
Heart disease other
11.3
7.4
13
12
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
4.5
7.3
18
42
I44.3
ICD-10 Finland
Other and unspecified atrioventricular block
+∞
7.3
7
*
74619
ICD-8 Finland
Congenital anomalies of heart, Transposition of great vessels
+∞
7.3
7
*
FLE96
NOMESCO Finland
Other repair of outlet obstruction of left ventricle
+∞
7.3
7
*
Q21.19
ICD-10 Finland
Atrial septal defect NOS
+∞
7.3
7
*
I37.0
ICD-10 Finland
Pulmonary valve stenosis
+∞
7.3
7
*
Q21.0
ICD-10 Finland
Ventricular septal defect
+∞
7.3
7
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.7
7.3
24
70
81
HP
Angiography of the heart and coronary arteries
8.3
7.2
15
19
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
30.9
7.2
9
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
7.1
61
302
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
7.0
55
262
ZX199
NOMESCO Finland
Other rote
14.3
6.9
11
8
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
8.6
6.9
14
17
602
Kela drug reimbursment
Children's severe malnutrition
6.0
6.9
18
32
XF640, ,
NOMESCO Finland
11.4
6.9
12
11
ZXA00
NOMESCO Finland
Right side
2.4
6.9
56
271
I50.0
ICD-10 Finland
Congestive heart failure
7.5
6.8
15
21
XF620
NOMESCO Finland
Examination of circulation with color method
41.1
6.8
8
*
Z94.1
ICD-10 Finland
Heart transplant status
23.2
6.7
9
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
10.4
6.6
12
12
F83
ICD-10 Finland
Mixed specific developmental disorders
4.1
6.5
18
46
B01AB05
ATC
enoxaparin; parenteral
2.3
6.5
59
298
B34.9
ICD-10 Finland
Viral infection, unspecified
3.3
6.5
25
81
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
71.5
6.5
7
*
Z13.6
ICD-10 Finland
Special screening examination for cardiovascular disorders
71.5
6.5
7
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.5
6.4
23
71
K78
ICPC
Atrial fibrillation/flutter
6.9
6.4
15
23
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
3.1
6.4
28
98
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.6
6.4
22
66
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
18.6
6.3
9
5
Q26.3
ICD-10 Finland
Partial anomalous pulmonary venous connection
+∞
6.3
6
*
FDJ00
NOMESCO Finland
End to end reconstruction of aorta for coarctation
+∞
6.3
6
*
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
+∞
6.3
6
*
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
+∞
6.3
6
*
FPH10
NOMESCO Finland
Open removal of transvenous cardiac pacemaker or cardioverter-defibrillator
+∞
6.3
6
*
1EA01, ,
NOMESCO Finland
+∞
6.3
6
*
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
+∞
6.3
6
*
FLE00
NOMESCO Finland
Excision of subvalvular membrane of left ventricle
+∞
6.3
6
*
3A566, ,
NOMESCO Finland
+∞
6.3
6
*
Q26.8
ICD-10 Finland
Other congenital malformations of great veins
+∞
6.3
6
*
Q21.30
ICD-10 Finland
Tetralogy of Fallot
+∞
6.3
6
*
FFK20
NOMESCO Finland
Atrio-pulmonary anastomosis
+∞
6.3
6
*
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
27.4
6.3
8
*
7AX01, ,
NOMESCO Finland
27.4
6.3
8
*
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.9
6.2
31
117
Z3229
NOMESCO Finland
Other healthcare associate professional
2.7
6.2
34
135
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
6.2
68
372
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.5
6.1
21
63
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.7
6.1
20
58
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.9
6.1
29
107
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
159
304
12.23
93.42
9.8
3.2
887.10
824.42
ng/l
0.11
151
245
44
17
31.05
64.71
3.8
3.4
76.59
114.35
%
3.36
44
17
73
95
10.36
55.73
17.1
10.4
86.16
92.11
%
1.11
73
95
170
596
6.55
48.26
24.9
7.4
1.60
1.13
inr
3.08
34
177
100
243
6.12
41.92
8.5
3.2
2884.07
195.39
ng/l
1.48
88
153
58
87
8.33
38.71
4.8
6.7
173.66
171.41
%
0.07
58
87
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
38
39
11.27
33.80
35.3
16.9
0.33
0.27
u/ml
0.63
20
23
125
443
4.57
31.93
3.6
3.1
—
—
—
0
0
103
378
3.89
23.85
6.4
3.4
1.64
1.15
mg/l
0.73
80
297
61
158
4.76
22.51
23.7
10.9
0.24
0.46
mmol/l
0.21
52
125
160
809
3.62
22.18
4.0
3.1
—
—
—
0
0
69
203
4.29
21.56
16.1
9.6
106.65
104.40
mmol/l
3.61
69
203
67
195
4.30
21.21
3.7
2.9
18.88
22.63
%
1.75
62
179
43
98
5.07
18.32
31.9
10.6
0.65
0.71
%
0.66
43
98
43
99
5.02
18.10
31.8
10.5
1.17
1.39
%
0.46
43
99
135
679
3.10
17.66
8.6
6.7
37.47
36.80
g/l
0.70
129
655
162
924
3.06
16.55
17.4
10.5
1.20
1.22
mmol/l
4.44
156
829
26
40
7.12
16.52
7.3
18.0
71.45
68.28
%
0.38
26
40
83
332
3.22
15.89
15.6
10.4
1.30
1.24
mmol/l
0.72
78
316
175
1100
2.88
13.93
14.9
6.4
6.26
6.27
mmol/l
0.02
163
1007
99
471
2.80
13.57
4.7
3.0
81.69
24.78
ng/l
0.84
58
258
35
88
4.45
13.11
7.0
11.1
0.71
0.59
%
1.39
35
88
146
879
2.54
11.99
12.6
7.1
20.50
16.40
umol/l
0.81
139
831
73
318
2.81
11.59
20.8
13.9
24.66
24.69
mmol/l
0.04
73
318
92
457
2.58
11.22
3.5
3.0
3.03
3.04
mg/l
0.01
84
404
63
266
2.81
10.52
1.8
1.9
—
—
—
0
0
52
201
2.99
10.18
1.8
1.9
—
—
—
0
0
242
1976
5.39
9.86
31.0
13.2
4.00
3.95
mmol/l
1.84
242
1916
241
1973
5.02
9.53
31.1
13.2
139.46
139.60
mmol/l
0.50
241
1920
69
327
2.52
9.04
10.4
9.5
0.66
1.37
mmol/l
0.86
56
251
49
201
2.78
8.53
1.8
1.8
—
—
—
0
0
18
41
4.64
7.55
1.3
1.5
—
—
—
0
0
61
295
2.40
7.53
16.3
9.0
1.54
0.67
mmol/l
2.06
48
213
61
299
2.37
7.29
16.5
8.9
4.93
5.00
kpa
0.41
61
283
138
935
2.03
7.15
4.0
3.1
87.46
73.33
ug/l
0.51
133
877
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
10
8
12.93
6.13
1.3
1.4
119.10
124.75
%
—
10
8
65
374
1.99
5.04
3.5
3.2
1.05
0.71
e6/l
0.80
37
209
17
51
3.50
4.97
7.6
13.2
—
3087.13
—
0
8
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
8
7
11.73
4.81
1.8
1.0
80.00
148.29
%
—
8
7
100
677
1.78
4.63
4.9
4.0
—
—
—
0
0
236
2088
2.74
4.58
22.0
11.8
22.98
21.99
mg/l
0.21
198
1496
88
581
1.78
4.39
4.5
3.7
0.42
0.33
e6/l
0.19
67
415
14
34
4.29
4.27
1.2
1.0
1.50
1.53
u/ml
—
6
15
11
23
4.94
3.91
2.6
4.3
5.04
4.92
kpa
0.21
11
23
11
26
4.37
3.54
2.3
1.8
—
—
—
0
0
25
113
2.34
3.54
2.6
2.8
77.00
79.55
ml/min/173m2
—
9
47
6
6
10.19
3.51
6.3
10.5
1.21
1.28
mmol/l
—
6
6
185
1550
1.70
3.51
15.7
9.2
95.84
93.23
ml/min/173m2
0.74
153
1163
12
32
3.88
3.43
1.0
1.0
—
—
—
0
0
123
938
1.60
3.36
5.7
4.8
0.00
0.00
estimate
-0.00
18
165
123
941
1.59
3.30
4.0
3.4
0.00
0.00
estimate
-0.00
20
168
9
19
4.86
3.26
3.7
5.6
—
—
—
0
0
21
92
2.40
3.19
1.7
1.6
—
—
—
0
0
123
948
1.57
3.15
4.0
3.4
0.00
0.00
estimate
-0.00
18
159
57
362
1.74
3.15
3.6
3.4
3.38
2.41
e6/l
0.39
30
199
17
68
2.61
3.11
2.1
2.1
—
—
—
0
0
160
1316
1.58
3.04
11.7
11.6
3.74
3.72
e9/l
0.04
147
1109
17
69
2.57
3.02
2.3
2.4
—
—
—
0
0
16
63
2.64
3.01
2.4
2.1
1.12
1.30
g/l
0.48
11
56
56
361
1.70
2.93
4.4
3.8
4.74
14.99
mg/mmol
1.67
42
239
24
117
2.16
2.87
1.5
1.7
—
—
—
0
0
14
53
2.73
2.84
2.3
2.3
—
—
—
0
0
14
53
2.73
2.84
2.3
2.3
—
—
—
0
0
10
30
3.42
2.63
1.5
1.2
—
—
—
0
0
12
45
2.75
2.48
2.5
2.3
—
—
—
0
0
12
45
2.75
2.48
2.5
2.3
—
—
—
0
0
9
27
3.41
2.41
1.6
1.7
—
—
—
0
0
12
46
2.69
2.39
5.0
4.8
—
—
—
0
0
7
19
3.75
2.16
1.0
1.0
85.14
94.95
%
—
7
19
12
49
2.52
2.13
1.5
1.8
—
—
—
0
0
65
470
1.51
2.09
4.1
3.7
0.00
0.01
estimate
0.50
19
159
13
56
2.39
2.08
1.8
1.9
—
—
—
0
0
7
20
3.57
2.07
2.3
1.3
—
—
—
0
0
11
44
2.57
2.03
1.3
2.0
—
—
—
0
0
87
672
1.45
2.00
4.1
3.3
—
—
—
0
0
26
157
1.73
1.73
5.7
6.6
—
—
—
0
0
18
97
1.92
1.70
2.3
2.1
203.85
168.81
u/ml
0.18
13
52
8
31
2.63
1.67
1.6
3.6
57.75
56.23
%
—
8
31
18
98
1.90
1.66
4.1
4.6
1.23
1.23
mmol/l
0.11
18
86
247
2377
2.22
1.65
37.3
17.6
134.58
135.08
g/l
0.20
247
2349
247
2374
2.26
1.65
40.1
17.9
40.00
40.17
%
0.19
239
2274
8
33
2.47
1.55
1.6
1.4
—
—
—
0
0
7
28
2.54
1.46
1.3
2.1
—
—
—
0
0
5
18
2.81
1.29
2.8
3.3
2.30
3.74
nmol/l
—
5
18
5
18
2.81
1.29
1.2
1.7
—
—
—
0
0
17
101
1.73
1.23
2.4
2.1
—
—
—
0
0
93
778
1.31
1.22
3.7
2.8
72.47
71.93
nmol/l
0.07
88
719
5
19
2.66
1.22
2.4
2.3
107.20
105.11
mmol/l
—
5
19
8
41
1.98
1.09
1.8
2.0
—
—
—
0
0
179
1645
1.29
1.08
4.7
3.6
1.39
1.46
mmol/l
1.66
179
1549
7
33
2.15
1.06
1.6
2.1
—
—
—
0
0
7
33
2.15
1.06
1.0
1.2
—
—
—
0
0
5
22
2.30
1.03
1.2
1.0
77.00
77.27
%
—
5
22
10
53
1.92
1.02
1.8
2.3
—
—
—
0
0
5
23
2.19
0.98
3.4
2.0
23.80
28.48
umol/l
—
5
23
157
1430
1.25
0.97
4.4
4.3
7.70
9.13
mm/h
1.36
149
1340
9
52
1.76
0.93
1.8
2.1
—
—
—
0
0
9
52
1.76
0.93
1.0
1.3
—
—
—
0
0
15
94
1.63
0.92
1.5
1.4
—
—
—
0
0
15
94
1.63
0.92
1.5
1.4
—
—
—
0
0
15
94
1.63
0.92
1.5
1.4
—
—
—
0
0
15
94
1.63
0.92
1.5
1.4
—
—
—
0
0
222
2116
1.37
0.92
15.4
9.3
28.14
26.10
u/l
1.21
222
2047
8
43
1.89
0.88
1.7
1.8
—
—
—
0
0
22
303
0.70
0.83
1.3
1.2
1.04
10.48
u/ml
2.69
12
117
8
46
1.76
0.83
1.0
1.5
—
—
—
0
0
167
1552
1.22
0.76
4.2
3.7
15.14
14.53
pmol/l
2.64
162
1447
15
100
1.53
0.74
1.3
1.2
—
—
—
0
0
9
55
1.66
0.74
1.9
1.6
—
—
—
0
0
17
117
1.48
0.73
1.9
1.3
—
—
—
0
0
7
41
1.73
0.70
2.6
1.8
—
—
—
0
0
16
224
0.69
0.68
1.1
1.1
—
—
—
0
0
62
718
0.82
0.67
1.5
1.6
0.57
3.00
u/ml
3.19
15
147
10
62
1.64
0.66
2.2
1.4
—
—
—
0
0
10
62
1.64
0.66
2.2
1.4
—
—
—
0
0
7
44
1.61
0.65
2.3
2.5
143.29
133.68
g/l
—
7
31
14
198
0.69
0.63
1.2
1.6
—
—
—
0
0
19
139
1.40
0.62
3.2
2.9
—
—
—
0
0
5
86
0.57
0.57
1.2
1.6
—
—
—
0
0
15
109
1.40
0.52
1.5
1.5
—
—
—
0
0
16
118
1.38
0.51
2.6
1.8
—
—
—
0
0
62
551
1.16
0.44
2.0
1.7
82.51
96.62
pmol/l
2.04
33
275
8
58
1.39
0.42
1.3
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
2.5
—
64.00
—
0
15
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
5.4
—
21.75
—
0
16
0
17
0.00
0.41
0.0
1.7
—
2.76
—
0
17
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
18
143
1.28
0.38
2.9
1.8
9.29
12.93
nmol/l
0.88
18
134
22
181
1.23
0.35
1.5
1.5
—
—
—
0
0
6
43
1.40
0.35
2.8
1.5
—
—
—
0
0
10
73
1.38
0.35
1.5
2.5
—
—
—
0
0
17
136
1.27
0.34
3.0
2.2
8.64
6.95
u/l
0.21
11
92
6
90
0.66
0.33
1.2
1.6
4.77
2.74
mg/l
—
6
63
8
107
0.74
0.29
2.9
1.6
—
—
—
0
0
8
110
0.72
0.29
2.1
2.0
—
—
—
0
0
27
235
1.17
0.26
3.4
3.8
23.94
23.89
%
0.01
12
98
5
74
0.67
0.26
1.6
1.6
—
—
—
0
0
5
42
1.19
0.21
1.2
1.4
0.44
33.90
u/ml
—
5
32
8
103
0.77
0.21
1.4
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
232.64
—
0
11
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
4.8
—
23.97
—
0
12
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
5
43
1.17
0.21
1.4
2.4
—
—
—
0
0
5
43
1.17
0.21
1.6
1.6
0.32
0.32
nmol/l
—
5
36
0
13
0.00
0.21
0.0
1.2
—
2.84
—
0
6
36
327
1.12
0.20
1.5
1.4
19.85
21.43
nmol/l
0.30
31
277
10
81
1.24
0.19
1.2
1.3
—
—
—
0
0
186
1820
1.08
0.18
4.0
3.9
—
—
—
0
0
5
69
0.72
0.17
1.6
1.4
—
—
—
0
0
14
162
0.86
0.17
1.3
1.3
146.12
175.01
iu/ml
—
5
62
38
410
0.91
0.16
2.2
2.2
—
—
—
0
0
69
724
0.93
0.15
2.0
1.9
—
—
—
0
0
23
210
1.10
0.12
2.0
1.8
—
—
—
0
0
17
153
1.12
0.11
2.7
2.1
12.21
17.17
iu/l
0.63
11
118
12
105
1.15
0.11
1.1
1.2
—
—
—
0
0
11
97
1.14
0.09
1.2
1.3
—
—
—
0
0
5
60
0.83
0.08
1.4
1.3
—
—
—
0
0
5
62
0.80
0.08
1.0
1.0
2.90
3.24
kpa
—
5
56
5
64
0.78
0.08
1.0
1.0
6.94
7.42
kpa
—
5
58
165
1632
1.03
0.05
4.7
3.4
5.83
5.66
mmol/l
1.04
157
1509
126
1273
0.98
0.04
4.5
3.4
54.75
37.75
u/l
1.96
120
1225
33
319
1.04
0.03
1.5
1.4
—
—
—
0
0
14
149
0.94
0.03
1.2
1.3
—
—
—
0
0
30
309
0.97
0.02
1.2
1.3
11.33
32.19
iu/ml
—
6
88
18
186
0.96
0.01
1.9
2.6
0.47
0.78
ug/l
2.89
12
109
26
265
0.98
0.00
2.3
1.9
—
—
—
0
0
44
445
0.99
0.00
2.5
2.4
—
—
—
0
0
11
107
1.03
0.00
1.0
1.4
186.22
324.86
miu/ml
—
5
53
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
95.75
—
0
8
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
7.75
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
7
73
0.96
-0.00
1.3
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
60
1.00
-0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
220.83
—
0
6
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
75
0.93
-0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
25.89
—
0
7
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
60
1.00
-0.00
2.0
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_CONGEN_MALFO_HEART and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_HEART | 2.577 [1.84, 3.61] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.577 |
During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 1004 females with Q17_OTHER_CONGEN_MALFO_HEART died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_CONGEN_MALFO_HEART | 2.584 [1.86, 3.59] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 936 males with Q17_OTHER_CONGEN_MALFO_HEART died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_CONGEN_MALFO_HEART.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.232% | 0.548% |
| 5 | 1.526% | 2.633% |
| 10 | 3.708% | 6.778% |
| 15 | 7.36% | 13.206% |
| 20 | 13.075% | 20.453% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_CONGEN_MALFO_HEART – Other congenital malformations of heart
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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