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R13

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Pectus excavatum

Endpoint Browser PheWeb

Q17_PECTUS_EXCAVATUM

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q67.6
  • Cause of death: ICD-10 — Q67.6

2 out of 7 registries used, show all original rules.

189

4. Check minimum number of events

None

189

5. Include endpoints

None

189

6. Filter based on genotype QC (FinnGen only)

177

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 177 68 109
Unadjusted period prevalence (%) 0.04 0.02 0.05
Median age at first event (years) 17.47 20.01 15.88

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
189
Matched controls
1890
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q67.6
ICD-10 Finland
Pectus excavatum
+∞
271.3
189
*
GAF03
NOMESCO Finland
Correction of pectus excavatum
+∞
69.1
62
*
GAF10
NOMESCO Finland
Removal of prosthetic material after correction of malformation of chest wall
+∞
67.9
61
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.0
27.2
49
90
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.6
23.8
93
331
WX302
NOMESCO Finland
Thoracal epidural anesthesy
17.3
20.3
32
22
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.5
16.2
47
129
WX408
NOMESCO Finland
General anesthesy, balanced
3.7
15.6
70
262
75630
ICD-8 Finland
Other congenital anomalies of musculoskeletal system, Pectus excavatum
+∞
13.7
13
*
Z31.5
ICD-10 Finland
Genetic counselling
5.3
12.8
28
60
7548A
ICD-9 Finland
Certain congenital musculoskeletal deformities, Other specified nonteratogenic anomalies[PECTUS EXCAVATUM]
+∞
12.6
12
*
XF404
NOMESCO Finland
Ambulatory ECG
6.4
12.6
22
38
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.2
10.6
23
49
Q67.7
ICD-10 Finland
Pectus carinatum
58.1
9.8
11
*
5853
FHL
Anterior thoracoplasty (funnel breast, chicken breast)
+∞
9.4
9
*
GAF96
NOMESCO Finland
Other correction of malformation of chest wall
+∞
8.4
8
*
GAD00
NOMESCO Finland
Thoracoplasty without plombage
+∞
8.4
8
*
R06.0
ICD-10 Finland
Dyspnoea
2.8
7.6
45
190
5859
FHL
Other operations in this group (eg removal of fixation plate)
+∞
7.3
7
*
L04
ICPC
Chest symptom/complaint
3.8
7.0
22
63
ZXE20
NOMESCO Finland
More than three and less than five hours
3.4
6.9
26
84
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
6.2
59
310

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
73
353
2.74
9.76
11.7
4.9
1.28
1.08
inr
1.12
23
132
27
83
3.63
7.73
5.5
13.9
2.15
0.55
mmol/l
0.98
22
64
172
1456
3.02
4.87
11.4
9.5
26.81
21.85
mg/l
0.95
126
1037
60
355
2.01
4.49
2.1
2.1
—
—
—
0
0
14
43
3.44
3.99
5.1
12.2
0.94
1.57
%
2.21
14
43
14
43
3.44
3.99
5.1
12.2
0.63
0.75
%
0.64
14
43
93
663
1.79
3.79
4.3
5.4
5.89
6.35
mmol/l
2.15
82
585
14
45
3.28
3.73
5.1
11.8
95.87
95.07
%
0.20
14
45
32
159
2.22
3.72
1.4
1.3
—
—
—
0
0
14
40
3.70
3.70
8.9
21.2
—
—
—
0
0
97
706
1.77
3.64
3.5
2.4
—
—
—
0
0
64
424
1.77
3.24
5.5
5.2
38.50
38.28
g/l
0.10
57
402
154
1314
1.93
3.10
11.8
9.5
3.91
3.90
mmol/l
0.14
147
1262
154
1316
1.92
3.06
11.5
9.4
139.87
139.69
mmol/l
0.60
147
1268
5
6
8.51
2.76
1.8
2.0
20.10
18.21
ug/l
—
5
6
184
1723
3.57
2.70
16.5
13.3
4.68
4.74
e12/l
1.20
178
1680
183
1716
3.09
2.57
16.6
13.4
249.91
255.39
e9/l
0.66
178
1675
16
69
2.44
2.56
1.6
1.3
—
—
—
0
0
21
104
2.15
2.47
5.1
8.5
104.67
104.63
mmol/l
0.02
21
104
183
1720
3.01
2.43
16.9
13.5
41.79
44.50
%
0.49
178
1628
35
210
1.82
2.42
2.3
2.3
—
—
—
0
0
68
490
1.61
2.41
6.3
8.5
1.20
1.22
mmol/l
1.44
59
427
183
1725
2.92
2.28
16.7
13.3
6.65
6.65
e9/l
0.01
178
1682
6
14
4.39
2.17
1.7
1.1
—
—
—
0
0
39
251
1.70
2.12
1.6
2.3
1.46
1.17
mg/l
0.18
22
171
0
57
0.00
2.09
0.0
1.5
—
61.67
—
0
6
61
444
1.55
2.03
6.1
8.0
1.20
1.22
mmol/l
1.36
55
415
7
21
3.42
1.98
1.1
1.2
168.33
229.72
pmol/l
—
7
21
166
1510
1.82
1.95
8.4
7.7
25.43
30.83
u/l
3.86
157
1453
12
52
2.40
1.92
6.0
13.2
—
—
—
0
0
44
303
1.59
1.84
2.7
2.4
24.67
14.48
ng/l
0.70
24
130
19
104
1.92
1.75
1.7
1.3
92.11
411.88
u/ml
0.81
19
98
20
115
1.83
1.60
1.1
1.1
—
—
—
0
0
54
403
1.48
1.56
1.8
1.7
—
—
—
0
0
15
79
1.98
1.54
4.5
6.5
—
—
—
0
0
168
1557
1.71
1.52
11.8
7.8
—
—
—
0
0
61
476
1.42
1.38
1.5
1.6
—
—
—
0
0
5
17
2.99
1.36
3.0
13.6
—
—
—
0
0
0
37
0.00
1.36
0.0
1.1
—
—
—
0
0
25
165
1.59
1.25
2.8
2.5
—
—
—
0
0
23
150
1.61
1.21
2.3
1.7
—
—
—
0
0
13
72
1.87
1.18
5.5
6.4
—
—
—
0
0
0
36
0.00
1.15
0.0
1.2
—
—
—
0
0
18
113
1.66
1.10
1.6
1.5
—
—
—
0
0
5
21
2.42
1.09
1.8
1.5
—
—
—
0
0
38
284
1.42
1.08
2.1
3.3
7.39
7.40
ph
—
5
43
12
67
1.84
1.07
1.2
1.1
—
—
—
0
0
7
33
2.16
1.06
3.4
4.7
—
—
—
0
0
35
259
1.43
1.05
2.4
3.0
—
—
—
0
0
20
131
1.59
1.05
2.8
6.9
3.06
1.38
mmol/l
1.10
20
98
105
924
1.31
1.02
4.4
3.5
7.33
6.72
mm/h
0.22
99
853
5
23
2.20
0.98
1.0
1.0
—
—
—
0
0
0
32
0.00
0.96
0.0
1.0
—
—
—
0
0
31
229
1.42
0.95
3.5
3.9
—
—
—
0
0
18
119
1.57
0.92
3.3
2.6
314.56
3863.11
u/l
—
5
50
16
103
1.60
0.91
1.8
1.4
1131.59
1003.11
nmol/l
—
8
81
86
746
1.28
0.90
6.1
7.0
0.21
0.18
e9/l
0.44
79
650
6
29
2.10
0.90
2.2
1.9
—
—
—
0
0
80
693
1.27
0.84
6.4
7.6
0.00
0.00
e9/l
-0.00
67
536
112
1014
1.26
0.79
3.4
3.5
15.01
14.52
pmol/l
1.51
104
924
131
1209
1.27
0.78
4.0
4.0
1.68
1.82
mu/l
1.14
116
1126
35
274
1.34
0.77
2.6
2.4
2.57
2.66
mg/l
0.11
28
237
6
106
0.55
0.75
1.5
2.6
—
—
—
0
0
70
608
1.24
0.70
2.9
2.7
70.12
77.80
ug/l
0.28
62
571
17
119
1.47
0.69
6.2
8.6
—
—
—
0
0
82
728
1.22
0.66
6.2
6.5
0.53
0.56
e9/l
0.56
73
626
82
728
1.22
0.66
6.2
6.5
0.04
0.04
e9/l
0.60
73
625
28
354
0.75
0.66
1.4
1.6
—
—
—
0
0
101
917
1.22
0.65
7.4
6.5
89.61
84.03
u/l
0.40
95
858
5
29
1.74
0.64
10.2
5.1
59.00
52.55
%
—
5
29
5
29
1.74
0.64
10.2
4.9
4.17
3.65
e9/l
—
5
29
118
1264
0.82
0.60
2.8
2.8
4.38
4.58
mmol/l
1.87
108
1204
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
6.1
—
—
—
0
0
0
23
0.00
0.58
0.0
3.0
—
—
—
0
0
77
687
1.20
0.58
7.0
6.9
—
—
—
0
0
18
134
1.38
0.55
2.8
6.8
6.46
5.84
kpa
1.67
18
129
39
326
1.25
0.54
1.3
1.5
96.04
98.23
pmol/l
0.08
20
166
41
345
1.24
0.54
1.8
2.8
55.34
56.33
u/l
0.08
32
319
38
317
1.25
0.54
2.5
3.0
0.00
0.01
estimate
0.50
14
122
9
136
0.64
0.53
1.1
1.3
—
—
—
0
0
6
39
1.56
0.53
4.0
7.7
0.72
0.78
%
—
6
39
118
1254
0.84
0.50
2.8
2.8
1.36
1.37
mmol/l
0.19
107
1190
68
607
1.19
0.50
2.5
2.8
0.00
0.00
estimate
-0.00
15
121
84
765
1.18
0.49
6.2
6.5
2.02
2.00
e9/l
0.08
76
677
36
424
0.81
0.48
1.9
1.5
1.71
2.14
g/l
1.23
21
256
10
68
1.50
0.48
2.0
3.7
—
—
—
0
0
120
1269
0.85
0.46
2.8
3.0
2.66
2.83
mmol/l
1.42
108
1199
80
731
1.16
0.44
5.8
6.3
32.87
31.00
%
0.82
75
695
40
461
0.83
0.43
1.9
1.7
—
—
—
0
0
67
604
1.17
0.43
2.4
2.8
0.00
0.00
estimate
-0.00
15
125
92
851
1.16
0.42
4.3
3.5
—
—
—
0
0
5
32
1.58
0.42
7.8
6.0
—
—
—
0
0
32
270
1.22
0.42
2.0
2.4
—
—
—
0
0
5
33
1.53
0.41
1.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
2.5
—
45886.67
—
0
15
8
60
1.35
0.41
1.6
2.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
66
599
1.16
0.39
3.4
3.9
0.00
0.00
estimate
-0.00
15
128
17
134
1.30
0.38
1.5
1.9
—
—
—
0
0
6
41
1.48
0.36
4.3
7.2
1.42
1.97
%
—
6
41
6
44
1.38
0.34
1.2
1.4
—
—
—
0
0
44
491
0.86
0.33
2.0
1.8
—
—
—
0
0
11
142
0.76
0.32
1.5
1.9
—
—
—
0
0
16
129
1.26
0.31
2.1
1.5
406.19
485.90
pmol/l
0.84
16
117
22
185
1.21
0.31
1.1
1.3
13.12
20.59
iu/ml
—
6
56
10
75
1.35
0.31
1.1
1.1
3.43
2.59
u/ml
—
5
51
89
838
1.12
0.29
8.6
8.5
3.60
3.98
e9/l
1.33
80
717
14
172
0.80
0.28
1.1
1.3
1.50
8.06
u/ml
—
7
72
21
179
1.19
0.26
7.7
2.8
104.09
978.21
ng/l
0.67
11
99
14
167
0.83
0.22
1.6
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
1476.60
—
0
10
0
10
0.00
0.21
0.0
2.8
—
60.10
—
0
10
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
72.50
—
0
10
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
5.4
—
2.92
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
64
601
1.10
0.21
1.9
2.3
—
—
—
0
0
5
43
1.17
0.21
1.4
2.0
—
—
—
0
0
6
48
1.26
0.20
1.2
1.1
—
—
—
0
0
6
48
1.26
0.20
1.2
1.1
—
—
—
0
0
117
1209
0.92
0.20
2.5
2.7
1.10
1.25
mmol/l
1.66
104
1144
34
373
0.89
0.20
6.2
6.9
—
—
—
0
0
11
131
0.83
0.17
1.5
1.3
—
—
—
0
0
106
1024
1.08
0.17
3.4
3.6
35.37
36.93
mmol/mol
1.71
101
970
8
72
1.12
0.16
1.0
1.1
—
—
—
0
0
9
79
1.15
0.15
1.2
1.6
—
—
—
0
0
7
85
0.82
0.15
6.0
6.0
80.14
63.31
ng/l
—
7
79
113
1152
0.95
0.09
2.8
2.8
5.42
5.56
mmol/l
1.02
100
1066
41
391
1.06
0.09
1.5
1.9
—
—
—
0
0
6
55
1.09
0.09
1.0
1.2
—
—
—
0
0
5
63
0.79
0.08
1.2
1.1
—
—
—
0
0
13
117
1.12
0.08
1.7
2.5
23.29
26.98
%
—
8
112
13
117
1.12
0.08
2.5
2.8
—
—
—
0
0
7
66
1.06
0.08
1.3
1.5
—
—
—
0
0
25
235
1.07
0.07
1.2
1.9
—
—
—
0
0
30
316
0.94
0.07
1.9
3.0
—
—
—
0
0
34
356
0.95
0.07
2.2
2.3
—
—
—
0
0
21
197
1.07
0.06
1.7
1.5
—
—
—
0
0
19
203
0.93
0.06
2.7
3.7
37.55
145.16
mg/l
1.44
12
153
10
111
0.90
0.06
1.2
1.2
—
—
—
0
0
43
415
1.05
0.06
2.4
3.4
37.52
31.16
e6/l
0.10
27
283
30
313
0.95
0.05
1.8
1.6
—
—
—
0
0
49
476
1.04
0.05
1.6
1.5
7.91
1.28
u/ml
0.41
11
107
19
201
0.94
0.05
1.2
2.0
—
—
—
0
0
30
312
0.95
0.04
1.9
3.1
0.10
0.25
e6/l
1.01
19
239
26
249
1.05
0.04
1.2
1.3
—
—
—
0
0
34
348
0.97
0.02
2.0
3.0
14.10
25.77
e6/l
0.74
25
275
17
177
0.96
0.01
1.3
1.2
—
—
—
0
0
25
254
0.98
0.00
1.2
1.9
—
—
—
0
0
21
207
1.02
0.00
3.6
4.3
6.16
26.04
mg/mmol
1.42
14
151
25
248
1.01
0.00
1.2
1.9
—
—
—
0
0
25
252
0.99
0.00
1.2
1.9
—
—
—
0
0
11
115
0.95
0.00
4.5
2.7
8.65
10.48
g/l
0.83
11
110
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
8
84
0.95
0.00
3.1
4.3
—
0.04
%
—
0
24
0
9
0.00
0.00
0.0
1.2
—
0.38
—
0
9
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
5.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
3.3
—
1.69
—
0
9
9
90
1.00
-0.00
1.2
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
25
250
1.00
-0.00
1.2
1.9
—
—
—
0
0
5
58
0.86
-0.00
1.4
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
1999.38
—
0
8
0
5
0.00
-0.00
0.0
1.6
—
23.38
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
284.20
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
5.36
—
0
5

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: Q17_PECTUS_EXCAVATUM – Pectus excavatum

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).