No definition available.
Asymptomatic human immunodeficiency virus [HIV] infection status
Z21_ASYMP_HUMAN_IMMUNODEFICIENCY_VIRUS_HIV_INFECTION_STATUS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
212 |
4. Check minimum number of eventsNone |
212 |
5. Include endpointsNone |
212 |
6. Filter based on genotype QC (FinnGen only) |
212 |
Control definitions (FinnGen only)
- Control exclude
- Z21_PERSONS_W_POTEN_HEALTH_HAZARDS_RELATED_COMMUNICAB_DISEA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Z2
Similar endpoints
↥List of similar endpoints to
Asymptomatic human immunodeficiency virus [HIV] infection status
based on the number of shared cases.
Similar with more cases:
- Persons with potential health hazards related to communicable diseases
- Certain infectious and parasitic diseases
- Factors influencing health status and contact with health services
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1034 | 286 | 725 |
| Only index persons | 929 | 274 | 655 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 37.15 | 31.93 | 39.40 |
| Only index persons | 36.71 | 31.33 | 38.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 212 | 42 | 170 |
| Unadjusted period prevalence (%) | 0.06 | 0.01 | 0.07 |
| Median age at first event (years) | 38.46 | 33.37 | 39.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 197
- Matched controls
- 1972
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z21
ICD-10 Finland
Asymptomatic human immunodeficiency virus [HIV] infection status
+∞
285.2
197
*
B23.1
ICD-10 Finland
HIV disease resulting in (persistent) generalized lymphadenopathy
12600.9
237.4
179
*
WW200
NOMESCO Finland
Immunization
269.4
168.3
157
28
B24
ICD-10 Finland
Unspecified human immunodeficiency virus [HIV] disease
854.6
127.5
112
*
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
56.5
106.8
130
65
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
19.3
54.9
90
82
Z25.1
ICD-10 Finland
Need for immunization against influenza
41.4
50.6
63
22
B23.8
ICD-10 Finland
HIV disease resulting in other specified conditions
+∞
47.9
44
*
A51.0
ICD-10 Finland
Primary genital syphilis
+∞
35.5
33
*
A56.3
ICD-10 Finland
Chlamydial infection of anus and rectum
+∞
32.2
30
*
A54.0
ICD-10 Finland
Gonococcal infection of lower genitourinary tract without periurethral or accessory gland abscess
+∞
24.5
23
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.6
22.8
120
496
A54.6
ICD-10 Finland
Gonococcal infection of anus and rectum
+∞
21.2
20
*
A56.0
ICD-10 Finland
Chlamydial infection of lower genitourinary tract
21.5
19.3
28
15
A51.3
ICD-10 Finland
Secondary syphilis of skin and mucous membranes
197.0
17.8
18
*
A63.0
ICD-10 Finland
Anogenital (venereal) warts
11.2
17.8
34
36
B23.0
ICD-10 Finland
Acute HIV infection syndrome
185.0
16.8
17
*
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
7.5
15.9
39
63
A51.9
ICD-10 Finland
Early syphilis, unspecified
+∞
15.8
15
*
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
8.0
14.4
33
48
B18.2
ICD-10 Finland
Chronic viral hepatitis C
13.5
13.5
23
19
A60.0
ICD-10 Finland
Herpesviral infection of genitalia and urogenital tract
26.4
12.7
17
7
K05.19
ICD-10 Finland
Gingivitis (chronic) ulcerative
12.9
12.2
21
18
J05AB01
ATC
aciclovir; systemic
3.8
11.7
56
188
Z01.2
ICD-10 Finland
Dental examination
2.9
11.4
106
567
TAB00
NOMESCO Finland
Lumbar puncture
7.0
10.6
26
42
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.3
10.4
32
69
K05.10
ICD-10 Finland
Gingivitis (chronic) NOS
4.0
9.9
41
120
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.6
9.8
35
89
A54.5
ICD-10 Finland
Gonococcal pharyngitis
57.9
9.7
11
*
K03.65
ICD-10 Finland
Deposits [accretions] on teeth betel
3.1
9.7
63
261
ZX114
NOMESCO Finland
Intramuscular
15.0
8.8
14
10
ULA02
NOMESCO Finland
Kolposcopy
6.1
8.6
23
42
QXA50
NOMESCO Finland
Skin cryotherapy, unspecified location
21.2
8.6
12
6
N05CF01
ATC
zopiclone; oral
2.7
8.6
71
339
A53.9
ICD-10 Finland
Syphilis, unspecified
93.9
8.5
9
*
K02.9
ICD-10 Finland
Dental caries, unspecified
11.5
7.9
14
13
B37.4
ICD-10 Finland
Candidiasis of other urogenital sites
46.9
7.8
9
*
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
3.0
7.7
49
196
WYA30
SPAT
NA
26.2
7.6
10
*
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
7.8
7.4
16
22
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
5.7
7.3
20
38
N06AB04
ATC
citalopram; systemic
2.8
7.3
50
211
Z20.2
ICD-10 Finland
Contact with and exposure to infections with a predominantly sexual mode of transmission
20.9
7.2
10
5
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
6.8
7.1
17
27
J05AB11
ATC
valaciclovir; oral
3.5
7.1
33
107
S02.51
ICD-10 Finland
Fracture of tooth, open
3.2
6.8
35
123
TLC02
NOMESCO Finland
Simple extraction of IUD
7.8
6.5
14
19
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
72.1
6.5
7
*
C10AA07
ATC
rosuvastatin; oral
2.6
6.3
50
227
QAJ99
NOMESCO Finland
Other aesthetic operations on skin of head or neck
+∞
6.3
6
*
O98.5
ICD-10 Finland
Other viral diseases complicating pregnancy, childbirth and the puerperium
+∞
6.3
6
*
R74
ICPC
Upper respiratory infection acute
2.4
6.2
62
319
D01AE16
ATC
amorolfine; topical
3.6
6.1
26
79
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
157
14
429.41
307.65
2.6
2.1
822.7
523.8
e6/l
—
18
5
69
56
17.78
73.87
6.5
1.5
—
—
—
0
0
72
67
15.76
71.00
6.4
1.7
—
—
—
0
0
195
651
25.88
68.74
14.9
3.6
35.1
35.8
u/l
0.08
195
619
180
617
13.70
58.70
5.3
5.6
39.6
36.8
g/l
10.56
180
592
192
761
17.14
52.56
3.9
2.7
0.0
0.0
estimate
0.00
17
128
192
768
16.90
51.82
6.6
3.7
0.0
0.0
estimate
0.00
17
130
192
774
16.69
51.20
3.9
2.7
0.0
0.0
estimate
0.00
17
120
212
1243
+∞
45.95
12.7
8.0
74.8
76.9
u/l
0.52
212
1185
36
20
21.48
45.71
1.0
1.1
—
—
—
0
0
192
945
11.94
36.24
6.0
5.8
6.0
6.8
mmol/l
11.81
192
895
84
208
6.03
34.56
5.4
1.7
—
—
—
0
0
77
185
5.97
32.54
4.9
1.6
—
—
—
0
0
22
13
18.77
26.71
2.0
1.5
—
—
—
0
0
101
396
3.96
21.65
3.8
2.6
0.1
0.4
e6/l
4.36
78
292
23
5
51.30
19.63
5.7
1.6
—
—
—
0
0
24
9
29.82
18.26
3.9
3.0
—
—
—
0
0
108
510
3.28
16.26
4.0
2.7
—
—
—
0
0
28
52
6.05
14.92
1.0
1.3
164.5
207.9
miu/ml
0.23
12
27
18
5
39.08
14.69
3.2
1.8
—
—
—
0
0
58
222
3.22
11.91
3.4
2.4
3.7
1.2
e6/l
0.39
27
108
196
1472
5.39
11.60
28.5
14.4
13.3
13.5
%
2.00
196
1451
67
283
3.00
11.58
1.3
1.3
20.0
21.7
nmol/l
0.48
62
252
60
248
2.98
10.69
3.3
2.3
0.8
1.0
e6/l
0.28
29
133
17
31
5.87
9.13
3.4
2.7
2.9
4.9
e9/l
2.91
17
31
17
31
5.87
9.13
3.4
2.8
49.4
57.7
%
1.94
17
31
35
116
3.42
8.92
2.0
2.4
74.4
70.8
ml/min/173m2
0.26
24
55
212
1912
+∞
8.86
23.1
9.6
34.9
33.3
u/l
0.46
212
1882
16
29
5.89
8.64
1.3
1.5
—
—
—
0
0
16
29
5.89
8.64
1.3
1.5
—
—
—
0
0
10
16
6.51
6.01
1.1
1.0
—
—
—
0
0
35
145
2.69
6.01
3.2
4.2
196.0
247.8
u/l
2.30
35
138
47
225
2.40
5.99
1.6
2.2
13.5
14.5
umol/l
0.38
47
212
28
108
2.83
5.48
1.6
1.4
—
—
—
0
0
52
271
2.22
5.41
2.2
2.0
2.7
3.1
mg/l
0.44
44
239
17
50
3.61
5.14
2.4
1.6
—
—
—
0
0
41
209
2.19
4.46
1.6
2.2
2.5
2.4
g/l
0.58
41
197
80
527
1.83
4.18
1.8
1.6
95.1
96.7
pmol/l
0.15
52
292
212
2018
+∞
4.16
30.9
17.0
144.3
143.8
g/l
0.20
212
2004
198
1759
2.90
3.91
27.9
12.5
42.6
42.4
%
0.19
179
1481
6
5
12.29
3.78
1.7
1.0
—
—
iu/ml
—
0
0
15
54
2.91
3.33
1.5
1.1
—
—
—
0
0
15
55
2.86
3.23
1.5
1.1
—
—
—
0
0
16
61
2.76
3.21
1.3
1.3
—
—
—
0
0
21
93
2.40
3.15
1.9
1.2
—
—
—
0
0
10
29
3.57
3.08
2.7
1.7
—
—
—
0
0
26
132
2.11
2.85
3.0
2.8
—
—
—
0
0
30
166
1.94
2.62
1.8
1.6
—
—
—
0
0
6
11
5.58
2.56
1.2
1.0
—
—
—
0
0
18
83
2.28
2.49
1.3
1.5
2.5
4.0
mg/l
0.44
18
55
50
716
0.61
2.48
2.9
3.1
25.2
21.7
%
0.44
24
235
26
140
1.98
2.45
2.2
3.4
0.6
2.0
mmol/l
0.82
19
118
5
8
6.37
2.38
1.0
1.0
33.0
25.0
umol/l
—
5
8
30
173
1.86
2.32
1.8
1.6
—
—
—
0
0
17
79
2.25
2.32
1.5
1.4
—
—
—
0
0
10
36
2.87
2.23
1.1
2.3
3.0
2.9
g/l
—
10
31
8
25
3.28
2.11
1.5
1.8
—
—
—
0
0
5
10
5.09
2.08
1.0
1.1
499.8
265.3
iu/ml
—
5
10
7
20
3.58
2.07
1.0
1.2
—
—
—
0
0
7
20
3.58
2.07
4.1
3.9
—
—
—
0
0
10
38
2.71
2.04
1.1
2.2
7.3
7.0
g/l
—
10
32
10
38
2.71
2.04
1.1
2.2
—
—
—
0
0
10
38
2.71
2.04
1.1
2.2
3.8
3.9
g/l
—
10
29
122
1414
0.68
2.03
4.9
3.2
61.6
54.0
u/l
0.41
114
1365
13
58
2.32
1.95
1.3
1.7
0.5
0.2
iu/ml
—
7
11
6
16
3.83
1.95
1.0
1.1
—
—
—
0
0
6
17
3.60
1.85
8.8
10.6
0.5
0.6
mmol/l
—
6
17
12
53
2.34
1.84
3.1
2.5
—
—
—
0
0
6
18
3.40
1.76
1.2
1.2
—
—
—
0
0
6
19
3.22
1.67
1.0
1.2
—
—
—
0
0
11
49
2.31
1.66
1.1
1.1
—
—
—
0
0
5
14
3.63
1.62
1.2
1.4
—
—
—
0
0
15
266
0.53
1.58
1.4
1.8
—
—
—
0
0
86
695
1.40
1.57
4.8
8.9
1.2
1.2
mmol/l
0.03
77
606
9
37
2.49
1.50
1.2
1.3
—
92.5
—
0
10
7
28
2.55
1.46
3.9
3.8
—
1188.4
—
0
5
41
292
1.50
1.45
3.1
3.2
187.8
289.4
ng/l
0.26
32
213
9
39
2.36
1.45
1.1
1.3
561.9
453.7
mg/l
—
9
39
38
269
1.50
1.39
2.1
3.5
0.8
0.8
mmol/l
0.08
33
255
34
237
1.52
1.33
1.8
1.8
—
—
—
0
0
73
881
0.74
1.28
3.2
3.2
1.7
1.5
ug/l
0.57
66
821
56
703
0.72
1.26
2.8
4.0
—
—
—
0
0
5
19
2.67
1.22
1.2
1.2
—
—
—
0
0
44
571
0.71
1.21
2.3
3.0
13.1
37.5
ng/l
2.66
21
347
0
33
0.00
1.17
0.0
1.6
—
—
—
0
0
9
163
0.53
1.14
7.2
8.4
—
—
—
0
0
48
608
0.73
1.13
5.1
2.6
—
—
—
0
0
18
112
1.66
1.13
2.5
1.8
230.1
218.0
pmol/l
0.28
18
106
10
52
1.97
1.08
1.5
1.3
—
—
—
0
0
17
106
1.66
1.06
1.2
1.7
—
—
—
0
0
7
35
2.03
1.01
1.0
1.0
—
1.7
—
0
20
0
31
0.00
0.97
0.0
1.6
—
—
—
0
0
6
33
1.84
0.79
1.0
1.1
—
—
—
0
0
6
34
1.79
0.77
1.2
1.2
3.4
3.7
mmol/l
—
6
34
45
366
1.29
0.75
2.0
2.3
—
—
—
0
0
5
26
1.94
0.71
1.4
1.4
—
—
—
0
0
5
26
1.94
0.71
1.6
1.4
—
—
—
0
0
5
26
1.94
0.71
1.4
1.4
—
—
—
0
0
44
530
0.79
0.70
2.5
2.3
1.0
0.6
ug/l
0.52
35
265
5
28
1.80
0.66
1.4
1.6
—
—
—
0
0
8
129
0.61
0.66
5.6
6.2
2.1
40.0
ug/l
—
8
109
6
35
1.73
0.58
1.0
1.3
—
—
—
0
0
37
441
0.80
0.54
1.3
2.4
366.5
4871.4
umol/l
1.30
31
400
51
445
1.19
0.47
6.3
3.6
2.4
2.4
mmol/l
0.39
44
405
138
1306
1.16
0.45
3.4
3.2
—
—
—
0
0
5
33
1.53
0.41
1.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
26
216
1.23
0.39
4.1
2.9
2.4
2.4
mmol/l
0.11
21
188
123
1165
1.13
0.36
3.1
3.4
13.7
14.6
pmol/l
5.45
117
1084
7
96
0.72
0.31
2.3
3.0
1.2
1.2
mmol/l
—
7
90
40
361
1.13
0.25
1.8
1.9
1.1
1.0
mg/l
0.12
33
279
5
39
1.29
0.23
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
18.8
—
0
10
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
46.7
—
0
12
0
13
0.00
0.21
0.0
4.3
—
70.9
—
0
13
0
14
0.00
0.20
0.0
1.8
—
4.0
—
0
8
0
14
0.00
0.20
0.0
2.4
—
14.6
—
0
14
6
49
1.23
0.20
1.0
3.1
0.7
1.0
nmol/l
—
6
44
22
248
0.87
0.19
1.3
1.2
6.7
5.0
u/ml
—
5
109
10
81
1.25
0.19
1.3
1.0
—
—
—
0
0
20
176
1.15
0.18
7.8
14.8
0.1
1.0
mmol/l
0.30
13
138
15
129
1.18
0.17
2.2
2.2
—
20.9
—
0
11
13
152
0.85
0.17
10.5
16.5
118.7
125.7
g/l
0.52
13
145
7
63
1.11
0.17
1.0
1.1
—
2.6
—
0
11
5
48
1.04
0.09
1.6
1.5
—
—
—
0
0
7
82
0.85
0.07
1.7
1.3
—
—
—
0
0
38
367
1.04
0.05
5.7
3.1
0.0
0.0
estimate
0.50
17
123
32
310
1.04
0.03
1.3
1.4
—
—
—
0
0
20
204
0.98
0.00
8.8
9.9
104.5
103.8
mmol/l
0.32
20
197
0
8
0.00
0.00
0.0
4.3
—
—
—
0
0
0
8
0.00
0.00
0.0
4.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
7.6
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
9
95
0.95
0.00
2.0
2.1
452.4
125.7
ng/l
—
9
80
0
6
0.00
0.00
0.0
1.2
—
208.0
—
0
6
0
5
0.00
0.00
0.0
1.4
—
63.4
—
0
5
0
7
0.00
0.00
0.0
1.1
—
230.6
—
0
7
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
3.9
—
—
—
0
0
0
7
0.00
0.00
0.0
3.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
27.8
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Z21_ASYMP_HUMAN_IMMUNODEFICIENCY_VIRUS_HIV_INFECTION_STATUS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Z21_ASYMP_HUMAN_IMMUNODEFICIENCY_VIRUS_HIV_INFECTION_STATUS | 2.926 [2.33, 3.68] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 694 males with Z21_ASYMP_HUMAN_IMMUNODEFICIENCY_VIRUS_HIV_INFECTION_STATUS died.
Mortality risk
Mortality risk for people of age
years, who have Z21_ASYMP_HUMAN_IMMUNODEFICIENCY_VIRUS_HIV_INFECTION_STATUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.587% |
| 5 | No data | 3.198% |
| 10 | No data | 7.823% |
| 15 | No data | 14.841% |
| 20 | No data | 24.18% |
Relationships between endpoints
↥Index endpoint: Z21_ASYMP_HUMAN_IMMUNODEFICIENCY_VIRUS_HIV_INFECTION_STATUS – Asymptomatic human immunodeficiency virus [HIV] infection status
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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